综合性期刊最新文献

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How I’m electrifying transportation in Tanzania 我是如何使坦桑尼亚的交通电气化的
IF 64.8 1区 综合性期刊
Nature Pub Date : 2025-08-04 DOI: 10.1038/d41586-025-02463-4
{"title":"How I’m electrifying transportation in Tanzania","authors":"","doi":"10.1038/d41586-025-02463-4","DOIUrl":"https://doi.org/10.1038/d41586-025-02463-4","url":null,"abstract":"Technician Erasto Job assembles and fixes electric three-wheelers for TRí, a sustainable transportation company in Dar es Salaam.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"33 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144769904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
To save lives in heatwaves, focus on how human bodies work 为了在热浪中拯救生命,关注人体是如何工作的
IF 64.8 1区 综合性期刊
Nature Pub Date : 2025-08-04 DOI: 10.1038/d41586-025-02461-6
Ollie Jay, Jennifer Vanos, Daniel Gagnon, Federico Tartarini
{"title":"To save lives in heatwaves, focus on how human bodies work","authors":"Ollie Jay, Jennifer Vanos, Daniel Gagnon, Federico Tartarini","doi":"10.1038/d41586-025-02461-6","DOIUrl":"https://doi.org/10.1038/d41586-025-02461-6","url":null,"abstract":"Strategies for heat-health preparedness should concentrate on cooling people, not just the air.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"20 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144769909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Who’s to blame when AI agents mess up? We urgently need a new system of ethics 当人工智能代理搞砸了,谁来负责?我们迫切需要一个新的道德体系
IF 64.8 1区 综合性期刊
Nature Pub Date : 2025-08-04 DOI: 10.1038/d41586-025-02454-5
Iason Gabriel, Geoff Keeling, Arianna Manzini, James Evans
{"title":"Who’s to blame when AI agents mess up? We urgently need a new system of ethics","authors":"Iason Gabriel, Geoff Keeling, Arianna Manzini, James Evans","doi":"10.1038/d41586-025-02454-5","DOIUrl":"https://doi.org/10.1038/d41586-025-02454-5","url":null,"abstract":"The deployment of capable AI agents raises fresh questions about safety, human–machine relationships and social coordination.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"27 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144769912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Polarization in the COVID-19 pandemic: The impact of vaccination status and conspiracy theories. COVID-19大流行中的两极分化:疫苗接种状况的影响和阴谋论。
IF 5.2 3区 综合性期刊
Annals of the New York Academy of Sciences Pub Date : 2025-08-04 DOI: 10.1111/nyas.15408
Lisa Willemsen,Chiara Serafini,John Butler,Sümeyye Ergün,Jan-Willem van Prooijen
{"title":"Polarization in the COVID-19 pandemic: The impact of vaccination status and conspiracy theories.","authors":"Lisa Willemsen,Chiara Serafini,John Butler,Sümeyye Ergün,Jan-Willem van Prooijen","doi":"10.1111/nyas.15408","DOIUrl":"https://doi.org/10.1111/nyas.15408","url":null,"abstract":"The COVID-19 pandemic gave rise to a new social identity through vaccination status and yielded substantial polarization between vaccinated and unvaccinated people. Across two studies conducted via online platform Prolific, we examined the polarization between vaccinated and unvaccinated people in the United States. Study 1 (N = 646) revealed that vaccinated people were more polarized toward unvaccinated people than vice versa across a range of polarization indicators. Conspiracy beliefs moderated these effects. Higher conspiracy beliefs predicted increased polarization among unvaccinated people; however, lower conspiracy beliefs predicted increased polarization among vaccinated people. Study 2 (N = 503) focused specifically on feelings of hate and revealed that vaccinated and unvaccinated people were polarized toward different target groups. While vaccinated people expressed more hate toward unvaccinated people than vice versa, unvaccinated people expressed more hate toward the government. Additional analyses indicated that besides public health concerns, feelings of hate also predicted vaccinated people's support for excluding unvaccinated people from public places. These findings offer novel insight into the complex dynamics that help explain the polarization that occurred among both vaccinated and unvaccinated people.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"21 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144769683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exposure to respirable desert dust entering indoors prompts quick oxidative-stress and inflammatory responses in the airways of chronic heart failure patients.
IF 3.9 2区 综合性期刊
Scientific Reports Pub Date : 2025-08-03 DOI: 10.1038/s41598-025-14289-1
Alberto Domínguez-Rodríguez, Pedro Abreu-Gonzalez, Sergio Rodríguez, Nestor Baéz-Ferrer, Pablo Avanzas, Jessica López-Darias, Ibtissem Belbachir, Gorka Villena-Armas, María Isabel García, Jon Vilches, Rocío Diaz, Daniel Hernández-Vaquero
{"title":"Exposure to respirable desert dust entering indoors prompts quick oxidative-stress and inflammatory responses in the airways of chronic heart failure patients.","authors":"Alberto Domínguez-Rodríguez, Pedro Abreu-Gonzalez, Sergio Rodríguez, Nestor Baéz-Ferrer, Pablo Avanzas, Jessica López-Darias, Ibtissem Belbachir, Gorka Villena-Armas, María Isabel García, Jon Vilches, Rocío Diaz, Daniel Hernández-Vaquero","doi":"10.1038/s41598-025-14289-1","DOIUrl":"https://doi.org/10.1038/s41598-025-14289-1","url":null,"abstract":"<p><p>A significant portion of the population is exposed to airborne PM<sub>10</sub> levels exceeding WHO guidelines, particularly during desert dust events, which are increasing due to climate change. Cardiovascular mortality has been linked to PM<sub>10</sub> exposure, but most studies rely on outdoor air quality data that may not reflect indoor exposure. This study, DESERT HEART, examines whether indoor PM<sub>10</sub> exposure during dust events influences airway inflammation and oxidative stress in 40 patients with stable chronic heart failure (HF). Sputum samples were collected weekly for three weeks, and biomarkers (IL-8, MDA, MMP-9, TGF-ß1, CRP) were analyzed. Indoor PM<sub>10</sub> levels were monitored at patients' homes. Mixed regression models assessed the impact of PM<sub>10</sub> ≥ 90 µg/m<sup>3</sup> on biomarkers. Analysis of 120 sputum samples and 720 days of air quality data showed that exposure significantly increased biomarker levels on the first day: IL-8 (+ 6.9 ng/gwt, p = 0.032), MDA (+ 1.3 nmol/gwt, p = 0.014), MMP-9 (+ 222.4 ng/gwt, p = 0.09), TGF-ß1 (+ 4.1 ng/gwt, p = 0.058), and CRP (+ 2 ng/gwt, p = 0.02), followed by a sharp decline. These findings suggest that indoor PM<sub>10</sub> exposure from desert dust events acutely exacerbates airway inflammation and oxidative stress in HF patients, highlighting the need for targeted interventions.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"28318"},"PeriodicalIF":3.9,"publicationDate":"2025-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pilot study of cerebrospinal fluid biomarkers reveals inflammatory changes in patients with paranoid schizophrenia.
IF 3.9 2区 综合性期刊
Scientific Reports Pub Date : 2025-08-03 DOI: 10.1038/s41598-025-13367-8
Franz Felix Konen, Philipp Sebastian Gehring, Hannah Benedictine Maier, Sebastian Schröder, Seda Nur Türker, Helge Frieling, Stefan Bleich, André Huss, Hayrettin Tumani, Daniel Lüdecke, Jürgen Gallinat, Berend Malchow, Niels Hansen, Jens Wiltfang, Alexandra Neyazi, Thomas Skripuletz
{"title":"Pilot study of cerebrospinal fluid biomarkers reveals inflammatory changes in patients with paranoid schizophrenia.","authors":"Franz Felix Konen, Philipp Sebastian Gehring, Hannah Benedictine Maier, Sebastian Schröder, Seda Nur Türker, Helge Frieling, Stefan Bleich, André Huss, Hayrettin Tumani, Daniel Lüdecke, Jürgen Gallinat, Berend Malchow, Niels Hansen, Jens Wiltfang, Alexandra Neyazi, Thomas Skripuletz","doi":"10.1038/s41598-025-13367-8","DOIUrl":"https://doi.org/10.1038/s41598-025-13367-8","url":null,"abstract":"<p><p>Paranoid schizophrenia is a severe mental illness with both positive and negative symptoms. Currently, the role of peripheral and central inflammation is increasingly suspected as possible factor in the pathogenesis of schizophrenia. This retrospective, monocentric pilot study investigated 35 patients (15/35 female) diagnosed with paranoid schizophrenia after exclusion of possible underlying neuroinflammatory disorders to assess for inflammatory changes of the cerebrospinal fluid (CSF) and associated signs of neurodegeneration. Kappa free light chains (KFLC), a panel of 21 cyto- and chemokines, and neurofilament light chains (NFL) as surrogate parameters for neuro-inflammation and -degeneration were determined in patients with paranoid schizophrenia as well as age- and sex-matched inflammatory (n = 35) and non-inflammatory controls (n = 40). Patients with paranoid schizophrenia exhibited significantly higher intrathecal synthesized fractions of KFLC than non-inflammatory controls. KFLC-positive patients with paranoid schizophrenia had significantly higher NFL concentrations in CSF than KFLC-negative patients according to Reiber´s diagram. NFL concentrations in CSF of patients with paranoid schizophrenia were associated with illness duration, frequency of psychotic episodes, and amount of antipsychotic treatment attempts. This pilot study highlights inflammatory changes in the CSF among a specific subgroup of patients with paranoid schizophrenia, positively correlating with elevated NFL levels in CSF.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"28319"},"PeriodicalIF":3.9,"publicationDate":"2025-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-throughput sequencing-based study on bacterial community structure and functional prediction of fermented bean curd from different regions in China.
IF 3.9 2区 综合性期刊
Scientific Reports Pub Date : 2025-08-03 DOI: 10.1038/s41598-025-13691-z
Xue Feng, Zhao Dong, Teng Hao
{"title":"High-throughput sequencing-based study on bacterial community structure and functional prediction of fermented bean curd from different regions in China.","authors":"Xue Feng, Zhao Dong, Teng Hao","doi":"10.1038/s41598-025-13691-z","DOIUrl":"https://doi.org/10.1038/s41598-025-13691-z","url":null,"abstract":"<p><p>In order to understand the bacterial community structure, microbial safety, and functional diversity of traditional fermented food-sufu (fermented bean curd) in China, high-throughput sequencing technology was employed to systematically analyze the bacterial community composition and functional profiles of sufu samples from eight different regions in China (Zunyi, Guizhou; Xiushan, Chongqing; Chengdu, Sichuan; Xinhua, Hunan; Ji'an, Jiangxi; Mouding, Yunnan; Guilin, Guangxi; and Shilin, Kunming). The results revealed that the predominant bacterial phyla in sufu included Proteobacteria, Firmicutes, Bacteroidota, and Actinobacteriota, with key genera such as Pseudomonas, uncultured Enterobacteriaceae, and Lactococcus. The sample from Ji'an, Jiangxi (JXR5), exhibited the highest bacterial species richness, while the sample from Shilin, Kunming (KMR8), showed the highest species diversity, indicating significant impacts of geographical location and production processes on microbial communities. Functional analysis demonstrated that the bacterial communities in sufu were primarily involved in metabolic pathways such as chemoheterotrophy, aerobic chemoheterotrophy, and fermentation. The sample from Xiushan, Chongqing (CQR2), had the highest proportion of fermentation-related functions, contributing to the formation of a finer texture and richer flavor. The sample from Guilin, Guangxi (GXR7), exhibited the highest aromatic compound degradation function, which may enhance flavor or reduce undesirable odors. Additionally, significant variations were observed in functions such as nitrate reduction, nitrogen respiration, and nitrate respiration among different samples, suggesting that microbial diversity in nitrogen metabolism may influence the safety and quality of sufu. This study highlights the regional characteristics and functional diversity of bacterial communities in sufu, providing a scientific basis for optimizing production processes and developing region-specific products.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"28317"},"PeriodicalIF":3.9,"publicationDate":"2025-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predictive model for feeding intolerance in neonates with hypoxic ischemic encephalopathy during therapeutic hypothermia.
IF 3.9 2区 综合性期刊
Scientific Reports Pub Date : 2025-08-03 DOI: 10.1038/s41598-025-14085-x
Zhongping Shui, Ying Liu, Haimei Duan, Qiuyi Sun, Huan He, Huayun He, Jianhui Wang, Huaying Yin
{"title":"Predictive model for feeding intolerance in neonates with hypoxic ischemic encephalopathy during therapeutic hypothermia.","authors":"Zhongping Shui, Ying Liu, Haimei Duan, Qiuyi Sun, Huan He, Huayun He, Jianhui Wang, Huaying Yin","doi":"10.1038/s41598-025-14085-x","DOIUrl":"https://doi.org/10.1038/s41598-025-14085-x","url":null,"abstract":"<p><p>To construct a nomogram for feeding intolerance (FI) during therapeutic hypothermia (TH) in neonates with hypoxic-ischemic encephalopathy (HIE). 179 neonates with HIE were recruited between March 2017 and July 2023 and clinical data subjected to least absolute shrinkage and selection operator (LASSO) regression and multivariable logistic regression analysis. A predictive model was constructed and verified by receiver operating characteristic (ROC) curve analysis, calibration plots and decision curve analysis (DCA). Neonatal infection, 5-min Apgar score, hypoglycemia, time of enteral nutrition initiation, initial enteral feeding volume (15-30 mL/kg/day) and rate of feeding advancement (1-5 mL/kg/day) were found to be independent predictors for FI. Earlier initiation, larger initial volume and rapid feeding progression increased FI risk and slow advancement was protective. ROC analysis gave an area under the curve (AUC) of 0.83 (95% CI: 0.77-0.89) and internal verification concordance index (C-index) was 0.829. DCA showed a favorable net clinical benefit for the FI predictive model. The predictive model may identify the causes of FI at an early stage and inform clinical decisions.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"28325"},"PeriodicalIF":3.9,"publicationDate":"2025-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coxiella burnetii and HIV infection in people experiencing homelessness.
IF 3.9 2区 综合性期刊
Scientific Reports Pub Date : 2025-08-03 DOI: 10.1038/s41598-025-09422-z
Danilo Alves de França, Louise Bach Kmetiuk, Anahi Chechia do Couto, Helio Langoni, Alexander Welker Biondo
{"title":"Coxiella burnetii and HIV infection in people experiencing homelessness.","authors":"Danilo Alves de França, Louise Bach Kmetiuk, Anahi Chechia do Couto, Helio Langoni, Alexander Welker Biondo","doi":"10.1038/s41598-025-09422-z","DOIUrl":"https://doi.org/10.1038/s41598-025-09422-z","url":null,"abstract":"<p><p>This study has investigated Coxiella burnetii and HIV infection among the persons experiencing homelessness of São Paulo city, Brazil, and assessed correspondent associated risk factors. A cross-sectional study was carried out with 203 individuals performing serological tests for anti-C. burnetii and anti-HIV antibodies. A prevalence of 14.8% (30/203) was found for anti-C. burnetii IgG antibodies, with titers ranging from 64 to 1024, while anti-HIV seroprevalence was 6.4% (13/203). No statistical association was found between C. burnetii and HIV seropositivity, or between seropositivity and assessed clinical and epidemiological variables. The findings herein highlight the high homelessness exposure to Q fever, possibly influenced by environmental factors such as dust aerosols, stray animal interactions and unsanitary living conditions. To the authors knowledge, this is the first serosurvey of C. burnetii in persons experiencing homelessness to date. The study herein has emphasized the importance of public health strategies targeting vulnerable populations, particularly in Brazilian major cities. Further C. burnetii surveys should be conducted to establish whether transmission may occur in other persons experiencing homelessness worldwide.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"28312"},"PeriodicalIF":3.9,"publicationDate":"2025-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Using an ordinary differential equation model to separate rest and task signals in fMRI 用常微分方程模型分离功能磁共振成像中休息和任务信号
IF 16.6 1区 综合性期刊
Nature Communications Pub Date : 2025-08-03 DOI: 10.1038/s41467-025-62491-6
Amrit Kashyap, Eloy Geenjaar, Patrik Bey, Kiret Dhindsa, Katharina Glomb, Sergey Plis, Shella Keilholz, Petra Ritter
{"title":"Using an ordinary differential equation model to separate rest and task signals in fMRI","authors":"Amrit Kashyap, Eloy Geenjaar, Patrik Bey, Kiret Dhindsa, Katharina Glomb, Sergey Plis, Shella Keilholz, Petra Ritter","doi":"10.1038/s41467-025-62491-6","DOIUrl":"https://doi.org/10.1038/s41467-025-62491-6","url":null,"abstract":"<p>Cortical activity results from the interplay between network-connected regions that integrate information and stimulus-driven processes originating from sensory motor networks responding to specific tasks. Separating the information due to each of these components has been challenging, and the relationship as measured by fMRI in each of these cases Rest (network) and Task (stimulus-driven) remains a significant open question in the study of large-scale brain dynamics. In this study, we develop a network ordinary differential equation (ODE) model using advanced system identification tools to analyze fMRI data from both rest and task conditions. We demonstrate that task-specific ODEs are essentially a subset of rest-specific ODEs across four different tasks from the Human Connectome Project. By assuming that task activity is a relative complement of rest activity, our model significantly improves predictions of reaction times on a trial-by-trial basis, leading to a 9% increase in explanatory power (<i>R</i><sup>2</sup>) across the 14 sub-tasks tested. We have additionally shown that these results hold for predicting missing trials and accuracy on a per individual basis as well as classifying Tasks trajectories or resulting dynamic Task functional connectivity. Our findings establish the principle of the Active Cortex Model, which posits that the cortex is always active and that Rest State encompasses all processes, while certain subsets of processes get elevated to perform specific task computations. Thus, this study is an important milestone in the development of the fMRI equation - to causally link large-scale brain activity, brain structural connectivity, and behavioral variables within a single framework.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"10 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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