综合性期刊最新文献

{"title":"Anthropogenic climate change may reduce global diazotroph diversity","authors":"Peng Li, Zhuo Pan, Jingyu Sun, Yu Geng, Yiru Jiang, Yue-zhong Li, Zheng Zhang","doi":"10.1038/s41467-025-62843-2","DOIUrl":"https://doi.org/10.1038/s41467-025-62843-2","url":null,"abstract":"<p>Climate change impacts microbial community structure and function, thus altering biogeochemical cycles. Biological nitrogen fixation by diazotrophs is involved in maintaining the balance of the global nitrogen cycle, but the global biogeographic patterns of diazotrophs and their responses to climate change remain unclear. In this study, we use a dataset of 1352 potential diazotrophs by leveraging the co-occurrence of nitrogenase genes (<i>nifHDK</i>) and analyse the global distribution of potential diazotrophs derived from 137,672 samples. Using the random forest model, we construct a global map of diazotroph diversity, revealing spatial variations in diversity across large scales. Feature importance shows that precipitation and temperature may act as drivers of diazotroph diversity, as these factors explain 54.2% of the variation in the global distribution of diazotroph diversity. Using projections of future climate under different shared socioeconomic pathways, we show that overall diazotroph diversity could decline by 1.5%–3.3%, with this decline further exacerbated by development patterns that increase carbon emissions. Our findings highlight the importance of sustainable development in preserving diazotrophs.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"36 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144928431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Backscattering in topological edge states despite time-reversal symmetry","authors":"Jonas Erhardt, Mattia Iannetti, Fernando Dominguez, Ewelina M. Hankiewicz, Björn Trauzettel, Gianni Profeta, Domenico Di Sante, Giorgio Sangiovanni, Simon Moser, Ralph Claessen","doi":"10.1038/s41467-025-63572-2","DOIUrl":"https://doi.org/10.1038/s41467-025-63572-2","url":null,"abstract":"<p>Spin-momentum-locked edge states of quantum spin Hall insulators provide a compelling platform for spintronic applications, owing to their intrinsic protection against backscattering from non-magnetic disorder. This protection emerges from time-reversal symmetry, which pairs Kramers partners of helical edge modes with opposite spin and momentum, thereby strictly forbidding elastic single-particle backscattering within the pair. Yet, contrary to the idealized notion of linear edge bands, the non-monotonic dispersions of realistic materials can host multiple Kramers pairs, reintroducing backscattering channels between them without violating time-reversal symmetry. Here, we investigate inter-Kramers pair backscattering in the non-linear edge bands of the quantum spin Hall insulator indenene, highlighting a critical aspect of edge state stability. Using quasiparticle interference in scanning tunneling spectroscopy – a direct probe of backscattering – we observe intra-band coupling between different Kramers pairs, while energy regions with only a single Kramers pair remain strictly protected. Supported by theoretical analysis, our findings provide an unprecedented experimental demonstration of edge state backscattering fully consistent with their underlying topological protection. This insight has profound implications for numerous quantum spin Hall insulator candidates, emphasizing that the mere presence of gap-traversing edge modes does not inherently guarantee their protection against backscattering.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"27 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144928436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A reconfigurable piezo-ionotropic polymer membrane for sustainable multi-resonance acoustic sensing","authors":"Wu Bin Ying, Joo Sung Kim, Zhengyang Kong, Zhe Yu, Elvis K. Boahen, Fenglong Li, Chao Chen, Ying Tian, Ji Hong Kim, Hanbin Choi, Jung-Yong Lee, Jin Zhu, Do Hwan Kim","doi":"10.1038/s41467-025-63643-4","DOIUrl":"https://doi.org/10.1038/s41467-025-63643-4","url":null,"abstract":"<p>Sensorineural hearing loss is the most common form of deafness, typically resulting from the loss of sensory cells on the basilar membrane, which cannot regenerate and thus lose sensitivity to sound vibrations. Here, we report a reconfigurable piezo-ionotropic polymer membrane engineered for biomimetic sustainable multi-resonance acoustic sensing, offering exceptional sensitivity (530 kPa^-1) and broadband frequency discrimination (20 Hz to 3300 Hz) while remaining resistant to “dying”. The acoustic sensing capability is driven by an ion hitching-in cage effect intrinsic to the ion gel combined with fluorinated polyurethane. In this platform, the engineered ionotropic polymer stretches under acoustic vibrations, allowing cations to penetrate the widened hard segments and engage in strong ion-dipole interactions (cation···F), thereby restricting ion flux and amplifying impedance changes. Additionally, the sensor’s sustainability is ensured through its self-healing properties and hydrophobic components, which enable effective self-repair in both conventional and aqueous environments without ion leakage, achieving a room-temperature healing speed of 0.3–0.4 μm/min. This sustainable acoustic sensing technology enables the devices to reliably identify specific sounds in everyday environments (e.g., human voices, piano notes), demonstrating their potential application as artificial basilar membranes.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"27 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144928440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"China’s chikungunya virus outbreak is a wake up call","authors":"","doi":"10.1038/d41586-025-02794-2","DOIUrl":"https://doi.org/10.1038/d41586-025-02794-2","url":null,"abstract":"Letter to the Editor","PeriodicalId":18787,"journal":{"name":"Nature","volume":"14 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144928332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Air taxis will soon be in our skies — if batteries can be made safer","authors":"Liqiang Mai, Xiaocong Tian, Yunlong Zhao","doi":"10.1038/d41586-025-02758-6","DOIUrl":"https://doi.org/10.1038/d41586-025-02758-6","url":null,"abstract":"Small electric aeroplanes flying at low altitude will need energy sources that can withstand crashes and deliver power reliably. Standards need to be decided now.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"31 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144928338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting ALDH16A1 mediated thioredoxin lysosomal degradation to enhance ferroptosis susceptibility in SMARCA4-deficient NSCLC","authors":"Guoshu Bi, Jiaqi Liang, Yunyi Bian, Guangyao Shan, Shencheng Ren, Haochun Shi, Xiaolong Huang, Junkan Zhu, Qun Wang, Wei Jiang, Boyi Gan, Cheng Zhan","doi":"10.1038/s41467-025-63687-6","DOIUrl":"https://doi.org/10.1038/s41467-025-63687-6","url":null,"abstract":"<p>Ferroptosis, an iron-dependent form of cell death, holds promise for cancer therapy. However, the intricate link between ferroptosis and oncogenic mutations remains unclear. Here we show that SMARCA4, a well-established tumour suppressor whose deficiency is associated with poor prognosis and resistance to treatments, sensitizes non-small cell lung cancer (NSCLC) cells to ferroptosis. Mechanistically, SMARCA4 promotes chromatin accessibility and expression of ALDH16A1. Surprisingly, ALDH16A1 lacks ALDH enzymatic activity, but binds to the anti-ferroptotic oxidoreductase thioredoxin (TXN), facilitating its translocation to the lysosome and subsequent degradation. Meanwhile, ALDH16A1 directly inhibits TXN’s oxidoreductase function by occluding its active site. We also show that either restoring ALDH16A1 levels or inhibiting TXN significantly enhances the effectiveness of chemo/immunotherapy in a ferroptosis-dependent manner in SMARCA4-deficient NSCLC. Collectively, our findings elucidate an intricate SMARCA4-ALDH16A1-TXN stability/function dual regulatory axis that governs ferroptosis and informs a therapeutic strategy for overcoming resistance to chemotherapy or immunotherapy in SMARCA4-deficient NSCLC.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"19 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144928397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human protein synthesis requires aminoacyl-tRNA pivoting during proofreading","authors":"Divya Sapkota, Karissa Y. Sanbonmatsu, Dylan Girodat","doi":"10.1038/s41467-025-63617-6","DOIUrl":"https://doi.org/10.1038/s41467-025-63617-6","url":null,"abstract":"<p>Rigorous studies have characterized the aa-tRNA selection mechanism in bacteria, which is essential for maintaining translational fidelity. Recent investigations have identified critical distinctions in humans, such as the requirement of subunit rolling and a tenfold slower proofreading step. Although these studies captured key intermediates involved in tRNA selection, they did not elucidate the transitions of aa-tRNA between intermediates. Through diverse structure-based simulations, we simulated 1856 aa-tRNA accommodation events into the human ribosomal A site. Here we show the requirement for a distinct ~30° pivoting of aa-tRNA about the anticodon stem within the accommodation corridor. This pivoting is crucial for navigating the crowded accommodation corridor, which becomes more constrained due to subunit rolling. Subunit rolling-dependent4 crowding increases the steric contributions of the accommodation corridor during aa-tRNA accommodation, consistent with the tenfold reduction in the rate of proofreading. Furthermore, we show that eEF1A interacts with the accommodating aa-tRNA through conserved basic residues, limiting premature aa-tRNA dissociation from the A site. These findings provide a structural description of the human aa-tRNA selection process and demonstrate that the aa-tRNA alignment relative to the ribosomal catalytic sites is a critical determinant of translational fidelity.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"14 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144928438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progressive changes in phenotype, transcriptome and proliferation capacity characterise continued maturation and migration of intestinal cDCs in homeostasis","authors":"Fabian T. Hager, Trong Hieu Nguyen, Asmae Laouina, Lydia Kopplin, Anna Andrusaite, Susan A. V. Jennings, Britta Simons, Andrea Leufgen, Thomas Clavel, Simon Milling, Immo Prinz, Reinhold Förster, Thomas Stiehl, Oliver Pabst, Vuk Cerovic","doi":"10.1038/s41467-025-63559-z","DOIUrl":"https://doi.org/10.1038/s41467-025-63559-z","url":null,"abstract":"<p>Conventional dendritic cells (cDCs) are important antigen presenting cells which link innate and adaptive immunity by transferring antigenic information from peripheral organs to T cells in lymph nodes (LNs). However, despite their central function in the induction of adaptive immune responses, the kinetics and molecular regulation of the cDC life cycle and migration remain poorly understood. Using a variety of in vivo techniques, we examine the kinetics of cDC turnover in the intestine and address the molecular changes throughout the various stages of the cDC life cycle – from tissue entry and differentiation to CCR7 upregulation and subsequent migration into draining LNs. Our data demonstrate that the life cycle of gut cDCs is highly dynamic, characterised by continuous alterations in transcriptome, protein expression and proliferation rates. These progressive changes culminate in cDC homeostatic activation and migration resulting in a resource-intensive daily turnover of up to a quarter of intestinal cDCs and an almost complete daily replacement of the migratory cDC compartment in the mesenteric LN. This high turnover rate ensures that the mesenteric LN maintains an accurate reflection of the intestinal immunological state, supporting rapid adaptation to emerging immune challenges.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"301 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144928388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plants with higher dispersal capabilities follow ‘abundant-centre’ distributions but such patterns remain rare in animals","authors":"Connor T. Panter, Stephan Kambach, Steven P. Bachman, Oliver Baines, Helge Bruelheide, Maria Sporbert, Georg J. A. Hähn, Richard Field, Franziska Schrodt","doi":"10.1038/s41467-025-63566-0","DOIUrl":"https://doi.org/10.1038/s41467-025-63566-0","url":null,"abstract":"<p>The ‘abundant-centre’ hypothesis posits that a species’ abundance is highest at its range centre and declines towards its range edge. Recently, the hypothesis has been much debated, with supporting empirical evidence remaining limited. Here, we test the hypothesis on 3660 species using 5,703,589 abundance observations. We summarise species-level patterns and test the effects of dispersal-related species traits and phylogeny on abundance–distance relationships. Support for the hypothesis is dependent on taxonomic group, with abundant-centre patterns being more pronounced for plants but non-significant when summarised across all animals. Dispersal capability does not explain abundance–distance relationships in animals but likely explains abundance patterns in non-woody plants. Phylogeny improves models of abundance–distance patterns for plants but not for animals. Despite this, controlling for phylogeny yields non-significant group-level results for plants, suggesting that only certain, phylogenetically clustered plant groups may conform to abundant-centre patterns. Overall, we demonstrate that abundant-centre patterns are not a general ecological phenomenon; they tend to not apply to animals but can manifest in certain plant groups, depending on dispersal capabilities and evolutionary histories. Leveraging species’ traits that account for dispersal improves models of abundant-centre patterns across geographic space.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"11 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144928482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An information-theoretic foreshadowing of mathematicians' sudden insights.","authors":"Shadab Tabatabaeian, Artemisia O'bi, David Landy, Tyler Marghetis","doi":"10.1073/pnas.2502791122","DOIUrl":"10.1073/pnas.2502791122","url":null,"abstract":"<p><p>The \"eureka\" insights that drive progress in science and mathematics remain shrouded in mystery. Sudden, unexpected, appearing like \"flashes of lightning\", these insights have the hallmarks of critical transitions in complex systems. Here, zooming in on mathematicians working on proofs in their own departments, we show that sudden insights are anticipated by a system-agnostic, information-theoretic early warning signal. Using dense behavioral recordings of mathematicians' moment-to-moment activity, we find that their blackboard interactions (e.g., writing, gesturing; [Formula: see text]) became increasingly unpredictable before an insight, analogous to the critical fluctuations that anticipate transitions in physical and ecological systems. We explore analytically when this early warning signal applies to varied systems with discrete, symbolic dynamics. While bibliometric analyses offer a zoomed-out perspective on innovation, publications are a coarse-grained record of individuals' insights. Explaining the sudden insights of innovators, from scientists to sculptors, requires attending to the local, distributed systems of their intellectual activity.</p>","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"122 35","pages":"e2502791122"},"PeriodicalIF":9.1,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144874890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}