Science Bulletin最新文献

{"title":"Prokaryotic biogeography across atmospheric, aquatic, and terrestrial ecosystems in the Mount Everest region","authors":"Yongqin Liu,&nbsp;Mukan Ji,&nbsp;Yuying Chen,&nbsp;Keshao Liu,&nbsp;Pengfei Liu,&nbsp;Yang Liu,&nbsp;Tandong Yao","doi":"10.1016/j.scib.2026.07.065","DOIUrl":"10.1016/j.scib.2026.07.065","url":null,"abstract":"<div><div>The Mount Everest region encompasses one of the world’s most fragile cryospheric landscapes, comprising diverse and interconnected habitats across atmospheric, aquatic, and terrestrial ecosystems. Despite growing interest in high-mountain microbial ecology, basin-scale assessments remain scarce. Here, we conducted a microbial survey in the Rongbuk River basin (3699–7000 m a.s.l.), analyzing 677 samples from aerosols, snow, stream water, stream sediments, and soils via 16S rRNA gene amplicon sequencing. We identified 58,141 operational taxonomic units (OTUs) across 67 prokaryotic phyla, dominated by Pseudomonadota, Actinomycetota, and Bacteroidota. Elevational diversity patterns were ecosystem-specific: richness declined with elevation in aerosols and stream water, showed a U-shaped pattern in snow, peaked at mid-elevations in soils, and remained stable in stream sediments. Evenness and Shannon diversity, however, displayed distinct elevational trends and environmental determinants compared to richness. Community assembly was largely stochastic in snow, aquatic, and soils but strongly deterministic in aerosols. Source-tracking analysis revealed strong landscape-scale connectivity, with snow serving as a microbial vector linking atmospheric inputs to downstream ecosystems (contributing 1.4%–12.0%). Soils served as a potential microbial reservoir, harboring 42% of the unique OTUs and contributing 3%–11.8% of communities to other habitats. While stream water and sediments showed reciprocal exchange, aerosols remained largely uncharacterized in terms of their sources. Collectively, these findings demonstrate that although prokaryotic responses to elevation are ecosystem-specific, these habitats are ecologically interconnected across the high-mountain landscape, providing a comprehensive overview of the prokaryotic biogeography of the region.</div></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 19","pages":"Pages 4861-4873"},"PeriodicalIF":20.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148872608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Activation-optimized anti-CD3 valency control enables combinatorial discovery of multi-specific nanoantibodies for solid tumor immunotherapy","authors":"Long Zhu,&nbsp;Ya-Jing Ma,&nbsp;Jian-Kang Kang,&nbsp;Xiu-Hai Che,&nbsp;Dong-Kun Zhao,&nbsp;Yin-Yi Cai,&nbsp;Yao-Ru Yu,&nbsp;Song Shen,&nbsp;Jun Wang","doi":"10.1016/j.scib.2026.08.080","DOIUrl":"10.1016/j.scib.2026.08.080","url":null,"abstract":"<div><div>Multi-specific antibodies that engage CD3 to redirect T cells have provided substantial clinical benefit in the treatment of hematologic malignancies, but their application to solid tumors remains constrained by a narrow therapeutic window and fixed molecular geometries that limit systematic optimization. Here we used a modular nano-adaptor framework to adjust anti-CD3 (αCD3) surface valency while maintaining antibody affinity, total antibody loading, and tumor-targeting capacity. By titrating the αCD3 stoichiometric fraction, we identified an activation-optimized conformation that preserves tumor-directed cytotoxicity while reducing non-specific immune activation and T cell exhaustion. This platform enabled rapid screening of 91 tetraspecific nanoantibody configurations that integrate immune checkpoint blockade, co-stimulatory signaling, and innate immune modulation. The lead candidates enhanced immune-tumor engagement, promoted intra-tumoral immune infiltration, and suppressed tumor growth in peripheral blood mononuclear cell (PBMC)-humanized mouse models with acceptable tolerability. These findings demonstrate that anti-CD3 valency control combined with modular combinatorial assembly is a potentially valuable and scalable strategy for the development of multi-specific immunotherapies against solid tumors.</div></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 19","pages":"Pages 5045-5057"},"PeriodicalIF":20.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148928696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A subset of endogenous P2X5 transcripts encodes ATP-sensitive receptor isoforms","authors":"Xiao-Na Yang,&nbsp;Dong-Ping Wang,&nbsp;Chen-Hui Shen,&nbsp;Xi Chen,&nbsp;Ai-Xin Zhang,&nbsp;Meng Zhang,&nbsp;Xing Zhou,&nbsp;Yun Tian,&nbsp;Peng Cao,&nbsp;Michael X. Zhu,&nbsp;Hui Yang,&nbsp;Chang-Run Guo,&nbsp;Ye Yu","doi":"10.1016/j.scib.2026.07.067","DOIUrl":"10.1016/j.scib.2026.07.067","url":null,"abstract":"<div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (233KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 19","pages":"Pages 4927-4931"},"PeriodicalIF":20.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148757548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drivers of the temporal and spatial variation in gully growth rates in Northeast China","authors":"Yanru Wen,&nbsp;Jingyue Li,&nbsp;Zhufeng Wang,&nbsp;Karl Auerswald,&nbsp;Peter Fiener,&nbsp;Wim Cornelis,&nbsp;Peng Qi,&nbsp;Ting-Yong Li,&nbsp;Xinhua Peng,&nbsp;Liming Ye,&nbsp;Wenbin Wu,&nbsp;Ming Jiang,&nbsp;Jiabao Zhang","doi":"10.1016/j.scib.2026.07.043","DOIUrl":"10.1016/j.scib.2026.07.043","url":null,"abstract":"<div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (423KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 19","pages":"Pages 4888-4890"},"PeriodicalIF":20.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148647979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrodynamic twisting enables bioinspired cellulose metafibers with exceptional strength and toughness","authors":"Tingting Yang,&nbsp;Zhaoxin Zhang,&nbsp;Zhiwei Liu,&nbsp;Xiaotong Fu,&nbsp;Shuze Zhu,&nbsp;Dongdong Ye","doi":"10.1016/j.scib.2026.07.069","DOIUrl":"10.1016/j.scib.2026.07.069","url":null,"abstract":"<div><div>Replacing high-performance synthetic fibers with sustainable bio-derived alternatives is critical for mitigating microplastic pollution but remains limited by the inferior mechanical performance of biomass-derived fibers. Here, we present bioinspired cellulose metafibers (Meta-CFs) enabled by a scalable hydrodynamic twisting strategy, wherein an asymmetric microfluidic field precisely guides the formation of continuously twisted architectures within a chemically cross-linked network, thereby locking in the ordered configuration and markedly suppressing defect accumulation. Multiscale experiments and simulations reveal that this strategy promotes efficient stress delocalization and cooperative load transfer. The resulting Meta-CFs achieve an unprecedented maximum tensile strength of 3.29 GPa (average 3.06 ± 0.23 GPa) and a toughness of 349.5 MJ m⁻³, simultaneously rivaling the strength of high-performance synthetic fibers and the toughness of natural spider silk. Furthermore, encapsulating multiple individual Meta-CFs with calcium alginate effectively scales up the bundle diameter while preserving GPa-level strength and full biodegradability. This upscaling strategy enables large-diameter structural applications, as demonstrated by durable trimmer lines that avoid the generation of persistent agricultural microplastic residues, thereby establishing a viable pathway toward high-performance, sustainable material alternatives.</div></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 19","pages":"Pages 4991-4998"},"PeriodicalIF":20.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148705024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineering heterostaple in atomically precise palladium cluster for efficient hydrogen peroxide electrosynthesis","authors":"Jiachun Li,&nbsp;Yan Sun,&nbsp;Min Du,&nbsp;Shuguang Wang,&nbsp;Baoliang Han,&nbsp;Jiacheng Wang,&nbsp;Xiaoyi Yang,&nbsp;Fangkai Wu,&nbsp;Fuling Liu,&nbsp;Xiaofeng Lei,&nbsp;Afang Dai,&nbsp;Zibao Gan,&nbsp;Xiuwen Zheng,&nbsp;Di Sun","doi":"10.1016/j.scib.2026.08.039","DOIUrl":"10.1016/j.scib.2026.08.039","url":null,"abstract":"<div><div>The deliberate construction of well-defined heterostaples within atomically precise metal clusters offers a powerful route to heterometallic systems with unconventional functionalities and promising catalytic potential. However, realizing such precise interface engineering in palladium-based clusters remains highly challenging. Here, we report the first successful synthesis of well-defined Pd₅Au₂ and Pd₅Cu₂ architectures featuring heterometallic interfaces by customizing dual-atom site (Au–Au or Cu–Cu) in atomically precise palladium cluster. Their structures were unambiguously determined by single crystal X-ray diffraction (SCXRD) and electrospray ionization mass spectrometry (ESI-MS). Both heterometallic clusters share a similar architecture, comprising a slightly folded Pd₅S hexatomic ring encapsulating a central antimony atom from PhSb²⁻ ligand, a M₂S₃ (M=Au or Cu) staple and four bridging thiolate ligands. Incorporation of the Au–Au or Cu–Cu subunit modulates the geometric and electronic environments of the palladium core to varying extents, leading to markedly distinct two-electron oxygen reduction reaction performances. Notably, Pd₅Au₂ achieves a nearly 100% H₂O₂ Faradaic efficiency at 25 mA cm⁻² and an exceptional H₂O₂ production rate of 1366.4 mmol g_cat⁻¹ h⁻¹ at 125 mA cm⁻². Its efficacy was further demonstrated in practical Fenton-type pollutant degradation. Density functional theory (DFT) calculations, corroborated by <em>operando</em> infrared spectroscopy, reveal that the introduction of an Au–Au dual-atom site induces an electronic redistribution that weakens the *OOH adsorption, thereby facilitating its hydrogenation step. This study represents the first realization of atomically precise palladium-based clusters equipped with heterometallic interfaces, providing new mechanistic insights and design principles for cluster-based catalysts in small-molecule energy conversion.</div></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 19","pages":"Pages 4956-4965"},"PeriodicalIF":20.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148878776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dark phonons as a polariton ruler for hidden interlayer deformations","authors":"Shengyu Hu,&nbsp;Jiahua Duan,&nbsp;Zhiwei Guo","doi":"10.1016/j.scib.2026.09.003","DOIUrl":"10.1016/j.scib.2026.09.003","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 19","pages":"Pages 4891-4893"},"PeriodicalIF":20.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148943841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From scar walls to neural bridges: a convergent paradigm for next-generation spinal cord injury repair","authors":"Senyu Yao,&nbsp;Xu Huang,&nbsp;Jun Kang,&nbsp;Bin Liu,&nbsp;Limin Rong","doi":"10.1016/j.scib.2026.07.016","DOIUrl":"10.1016/j.scib.2026.07.016","url":null,"abstract":"<div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (162KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 19","pages":"Pages 4902-4906"},"PeriodicalIF":20.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148496953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevation-dependent runoff shifts in the Mount Everest region","authors":"He Sun,&nbsp;Tandong Yao,&nbsp;Yi Zhang,&nbsp;Huabiao Zhao,&nbsp;Wei Yang,&nbsp;Zhongyan Wang,&nbsp;Zhenhua Xi,&nbsp;Weicai Wang","doi":"10.1016/j.scib.2026.04.020","DOIUrl":"10.1016/j.scib.2026.04.020","url":null,"abstract":"<div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (247KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 19","pages":"Pages 4854-4856"},"PeriodicalIF":20.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148142212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumor empowered binary macrophages regulate T cell interferon signaling to mediate immunotherapy resistance in gastric cancer","authors":"Tong Xie,&nbsp;Bohan Zhang,&nbsp;Lei Jiang,&nbsp;Wenwen Zhang,&nbsp;Boxin Liu,&nbsp;Yang Shi,&nbsp;Xiaotian Zhang,&nbsp;Jian Li,&nbsp;Yifan Zhang,&nbsp;Jun Zhou,&nbsp;Yanshuo Cao,&nbsp;Yakun Wang,&nbsp;Changsong Qi,&nbsp;Yun Zhang,&nbsp;Pei Zhang,&nbsp;Zhirong Shen,&nbsp;Lanjun Xu,&nbsp;Wenyan Wang,&nbsp;Lin Shen,&nbsp;Zhi Peng","doi":"10.1016/j.scib.2026.07.049","DOIUrl":"10.1016/j.scib.2026.07.049","url":null,"abstract":"<div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (228KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 19","pages":"Pages 4932-4936"},"PeriodicalIF":20.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148652729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}