Science Bulletin最新文献

{"title":"A low-temperature emergency power source designed from warm pastes based on hydrogel","authors":"Chuanchao Sheng ,&nbsp;Wei Li ,&nbsp;Sixie Yang ,&nbsp;Xiaowei Mu ,&nbsp;Xinyi Sun ,&nbsp;Hang Liu ,&nbsp;Haoshen Zhou ,&nbsp;Ping He","doi":"10.1016/j.scib.2025.05.036","DOIUrl":"10.1016/j.scib.2025.05.036","url":null,"abstract":"<div><div>Outdoor activities like mountain marathons and field expeditions often occur in harsh environments where maintaining power and body temperature are crucial for survival. Warm pastes are commonly used to provide warmth in cold conditions, but their potential as a portable power source has not been fully explored. This research develops an innovative approach to convert warm-paste chemical energy<span> into electrical power for emergencies. By designing a hydrogel-based iron-air battery with a low-temperature-resistant electrolyte, we created a battery capable of operating in low temperatures. Experimental results showed the battery generating 0.98 V of voltage and 2.68 Ah of capacity. The battery can be manually assembled using original warm paste materials and connected in series to power electronic devices like mobile phones, providing a vital communication tool in emergencies. This breakthrough offers a promising solution for enhancing safety and survival during outdoor activities.</span></div></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"70 19","pages":"Pages 3173-3182"},"PeriodicalIF":21.1,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144482731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A lectin receptor-like kinase TaSRK that is deacetylated by TaHDA9 regulates wheat grain length by mediating the photosystem II protein TaPsbO","authors":"Ning Zhang ,&nbsp;Songgang Li ,&nbsp;Zhipeng Sun,&nbsp;Jingjing Dai,&nbsp;Shuyu Zhang,&nbsp;Daiying Chen,&nbsp;Lei Zhao,&nbsp;Aolin Jia,&nbsp;Feng Chen","doi":"10.1016/j.scib.2025.04.028","DOIUrl":"10.1016/j.scib.2025.04.028","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"70 19","pages":"Pages 3120-3124"},"PeriodicalIF":21.1,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The westerlies-monsoon interaction shaped asymmetric lake expansions over the Tibetan Plateau in warming periods","authors":"Hao Long ,&nbsp;Jingran Zhang ,&nbsp;Shuai Zhang ,&nbsp;Yandong Hou ,&nbsp;Yubin Wu ,&nbsp;Na Yang ,&nbsp;Can Zhang ,&nbsp;Liangqing Cheng ,&nbsp;Zhijun Zhao ,&nbsp;Jun Cheng ,&nbsp;Ji Shen","doi":"10.1016/j.scib.2025.07.023","DOIUrl":"10.1016/j.scib.2025.07.023","url":null,"abstract":"<div><div>Modelling studies and recent observations suggest that the westerlies-monsoon interactions (WMI) have led to a spatial imbalance in lake expansions across the Tibetan Plateau (TP) during the past decades under anthropogenic warming. However, whether such imbalance reflects a short-term phenomenon or a long-term climatic trend remains unclear. Here, we present a 240,000-year lake level reconstruction from the inner TP to examine the extent to which WMI also operated for previous interglacials, natural warm regimes with large-scale climatic boundary changes. Results suggest pronounced lake expansions accompanied by enhanced rainfall during the recent three interglacials, marine isotope stage (MIS) 7, 5, and 1, notably with varying amplitudes of “V” shape (MIS 5 &lt; MIS 7 or MIS 1). This lake expansion pattern is coherent with North Hemisphere ice volume (NHIV) variations among these interglacials. Model simulation further suggests more NHIV may impact WMI by modulating westerlies’ position, causing rainfall increase and lake expansion over the inner TP relative to its marginal areas. Our findings confirm that the projected importance of WMI to drive the spatial heterogeneity of hydroclimate changes has been maintained during the past natural warm periods. We thus predict that the climate warming and NHIV decreasing will further amplify the spatial imbalance of lake expansions across the TP, with more pronounced lake expansions in the north relative to the south.</div></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"70 19","pages":"Pages 3245-3254"},"PeriodicalIF":21.1,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144858696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The mechanisms of MTOCs maturation in human and mouse oocytes","authors":"Hao Gu ,&nbsp;Ling Wu ,&nbsp;Mingru Yin ,&nbsp;Xingzhu Du ,&nbsp;Jing Fu ,&nbsp;Fangzhou Xu ,&nbsp;Zhiqi Ye ,&nbsp;Xuelin Zhang ,&nbsp;Huixia Jing ,&nbsp;Yuxi Luo ,&nbsp;Wenzhi Li ,&nbsp;Xiaoxi Sun ,&nbsp;Lin He ,&nbsp;Yanping Kuang ,&nbsp;Qifeng Lyu ,&nbsp;Tianyu Wu ,&nbsp;Lei Wang ,&nbsp;Qing Sang","doi":"10.1016/j.scib.2025.08.012","DOIUrl":"10.1016/j.scib.2025.08.012","url":null,"abstract":"<div><div>The microtubule organizing centers (MTOCs) of human and mouse oocytes are essential for meiotic spindle assembly and for ensuring precise chromosome segregations. Previous studies mainly focus on investigating MTOCs changes in metaphase I oocyte. However, the detailed dynamic changes and underlying mechanisms of the MTOCs in germinal vesicle (GV) oocytes—a stage that early events of MTOC maturation happened— remain unclear. Here we explored the dynamics of MTOCs maturation in human and mouse GV oocytes and found that MTOCs maturation is a largely conserved process, consisting of two tightly coupled processes referred to as MTOCs activation and migration. We found that cytoskeleton associated protein 5 (CKAP5) and transforming acidic coiled-coil containing protein 3 (TACC3) play key roles in MTOCs maturation in oocytes. The activation of the MTOCs is a prerequisite for migration initiation, and the migration of the MTOCs is facilitated by dynein/dynactin in oocytes. The disruption of MTOC maturation resulted in spindle assembly failure. Importantly, impaired MTOCs maturation is associated with the physiological aging of oocytes. This study provides a comprehensive understanding of MTOCs dynamics in human and mouse oocytes.</div></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"70 19","pages":"Pages 3202-3214"},"PeriodicalIF":21.1,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative scATAC-seq and mtDNA mutation analysis reveals disease-driven regulatory aberrations in AML","authors":"Chen Tian ,&nbsp;Yijun Dong ,&nbsp;Xin Sun ,&nbsp;Longchen Xu ,&nbsp;Xiaoli Ma ,&nbsp;Yuwei Tao ,&nbsp;Fang Wang ,&nbsp;Haohang Zhang ,&nbsp;Jie Li ,&nbsp;Kun Li ,&nbsp;Yasong Chen ,&nbsp;Hongxing Liu ,&nbsp;Xun Lan","doi":"10.1016/j.scib.2025.07.009","DOIUrl":"10.1016/j.scib.2025.07.009","url":null,"abstract":"<div><div>Disturbances in transcriptional regulation during hematopoiesis can lead to aberrant hematopoietic differentiation and potential leukemogenesis. Given the high relapse risk of acute myeloid leukemia (AML), understanding its progression mechanisms and identifying prognostic biomarkers are crucial for improving treatment outcomes. Here, we applied a mitochondrial single-cell assay for transposase-accessible chromatin with sequencing mitochondria single-cell ATAC-seq (mtscATAC-seq), supplemented with single-cell RNA-seq, to comprehensively characterize AML cells. By constructing a single-cell hematopoiesis reference and mapping tumor cells to it, we identified significant alterations in chromatin accessibility of cis-regulatory elements (CREs) associated with AML differentiation. Using an in-house developed algorithm, cisGRN, we analyzed CRE dynamics and discovered that mutations in the zinc finger domain of WT1 are associated with decreased chromatin accessibility and hypermethylation at the regulatory regions of their target genes, leading to gene downregulation. Functional validation confirmed the pathogenic effects of five WT1 zinc finger mutations: R467Q, R467L, R467W, H470Y, and H470R. Additionally, we identified a CRE mutation that emerges early in hematopoiesis, introducing a new binding motif for CCAAT enhancer binding protein beta (CEBPB), which facilitates its binding to the enhancer, activating enhancer activity and <em>GATA binding protein 4</em> (<em>GATA4</em>) expression, thereby promoting AML proliferation. These effects were validated through luciferase reporter assays and prime editing experiments. Using mitochondria DNA tracing and machine learning modeling, we identified relapse-associated clones resembling leukemia stem cells (LSCs) and uncovered marker genes in the clones that more accurately predict drug resistance and relapse risk. Collectively, our findings underscore the utility of combining mtscATAC-seq, lineage tracing, and gene regulatory network (GRN) analysis to uncover aberrant regulatory changes and track relapse-prone AML clones.</div></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"70 19","pages":"Pages 3215-3232"},"PeriodicalIF":21.1,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144803173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global burden of non-communicable diseases attributable to behavioral factors","authors":"Mengmeng Zhu ,&nbsp;Shihan Xu ,&nbsp;Yiwen Li ,&nbsp;Wenting Wang ,&nbsp;Longkun Liu ,&nbsp;Qian Xu ,&nbsp;Jing Cui ,&nbsp;Yanfei Liu ,&nbsp;Yue Liu","doi":"10.1016/j.scib.2025.08.037","DOIUrl":"10.1016/j.scib.2025.08.037","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"70 19","pages":"Pages 3129-3133"},"PeriodicalIF":21.1,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diradical self-assembled monolayers for perovskite photovoltaics","authors":"Anand S. Subbiah,&nbsp;Stefaan De Wolf","doi":"10.1016/j.scib.2025.08.013","DOIUrl":"10.1016/j.scib.2025.08.013","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"70 19","pages":"Pages 3093-3096"},"PeriodicalIF":21.1,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A copper-based single-atom material effectively controls plant diseases with nearly zero soil residue and low phytotoxicity","authors":"Rui Huang ,&nbsp;Yong Yan ,&nbsp;Yafei Jiang ,&nbsp;Chunyan Gu ,&nbsp;Zhentao Ma ,&nbsp;Lifang Xue ,&nbsp;Yao Ma ,&nbsp;Xingen Lin ,&nbsp;Juan Zhang ,&nbsp;Ran Shi ,&nbsp;Yiwen Wang ,&nbsp;Linjing Liu ,&nbsp;Chenhui Yang ,&nbsp;Xiaoping Gao ,&nbsp;Bo Yu ,&nbsp;Peigen Liu ,&nbsp;Wanyu Shen ,&nbsp;Haoran Zhang ,&nbsp;Cai Chen ,&nbsp;Xin Wang ,&nbsp;Yuen Wu","doi":"10.1016/j.scib.2025.08.018","DOIUrl":"10.1016/j.scib.2025.08.018","url":null,"abstract":"<div><div>A growing population necessitates the development of sustainable agriculture, which requires achieving atom economy in pesticide delivery, fertilization, and so on. To this end, we focus on single-atom materials (SAMs) to enhance atom utilization within agricultural systems. In this study, we report a novel pesticide for plants, a single-atom copper (Cu₁) formulation, by employing a precipitation-equilibrium-driven (<em>K</em>_sp-driven) method to anchor Cu₁ onto a calcium carbonate (CaCO₃) carrier. Thanks to its high atom dispersion and utilization efficiency, the Cu₁ formulation (Cu₁/CaCO₃) significantly enhances crop disease resistance while exhibiting minimal phytotoxicity in the tested species. Notably, this formulation leads to nearly 20-fold less copper residue in the soil after field application compared to traditional copper formulations. It inhibits microbial growth potentially by targeting key bacterial membrane components through interactions with phosphate groups (–PO₄^2–) in membrane phospholipids and binding to sulfhydryl (–SH) residues in respiratory chain proteins. Cu₁/CaCO₃ represents SAMs as a promising tool for designing green pesticides to manage crop diseases and a novel interdisciplinary approach to promoting sustainable agriculture.</div></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"70 19","pages":"Pages 3190-3201"},"PeriodicalIF":21.1,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144937941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemically gated ion transport in two-dimensional heterogeneous membranes with ultrahigh metal ion selectivity","authors":"Gang Yuan ,&nbsp;Junjie Fang ,&nbsp;Yukun Sun ,&nbsp;Jiaojiao Ma ,&nbsp;Hao Wang ,&nbsp;Wanqi Zhou ,&nbsp;Yu Jiang ,&nbsp;Chongyang Yang ,&nbsp;Zhihua Zhou ,&nbsp;Rong Hu ,&nbsp;Mingyang Xia ,&nbsp;Konstantin S. Novoselov ,&nbsp;Hu Qiu ,&nbsp;Sheng Hu","doi":"10.1016/j.scib.2025.05.040","DOIUrl":"10.1016/j.scib.2025.05.040","url":null,"abstract":"<div><div>Membranes are of particular importance in maintaining physiological activities, with crucial functions including selective permeation of certain ions. Such ion selectivity is achieved via complex molecular machinery to distinguish ions depending on their local physical–chemical environments, which are triggered by a variety of stimuli. Reproduction of such machinery in solid state systems is desirable for applications such as smart filtration, chemical sensing, and energy conversion, but remains a challenging task. We report regulated ion transport in artificial two-dimensional heterogeneous membranes, where the assembled polyacrylic acid macromolecules on the surface of functionalized graphene oxide membranes behave as a molecular regulator. The membrane exhibits chemically gated ion permeation, with the permeability of bi-valent metal cations tunable in response to the concentration of certain signaling ions. The chemistry gating effect is further found bi-valent ion-specific since it negligibly influences the rapid flow of monovalent metal cations. Molecular dynamics simulations reveal its origin as the high energy barriers required for reconfiguring the anion shells formed around bi-valent cations upon their entry. That also explains the observed mono-/bi-valent ion permeability ratio of up to &gt;10⁴. Our work allows fabricating membranes with implanted biomimetic functions of adaptive permeability and selectivity, governed by the choice of components and their responses to the chemical environments.</div></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"70 19","pages":"Pages 3183-3189"},"PeriodicalIF":21.1,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144300857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modeling spatial processes of extreme heat impacts on global economy: a multi-scale spatio-temporal approach","authors":"Guanpeng Dong ,&nbsp;Hang Zhang ,&nbsp;Yansui Liu ,&nbsp;Changhong Miao","doi":"10.1016/j.scib.2025.07.035","DOIUrl":"10.1016/j.scib.2025.07.035","url":null,"abstract":"<div><div>Rising frequency, intensity, and geographic scope of extreme heat profoundly impede global sustainable economic development. However, existing climate econometric models are limited in capturing the spatial processes through which extreme heat affects the global economy, often resulting in downward-biased estimates of total economic losses. This study develops a novel multi-scale spatio-temporal model that integrates classic multi-level modeling with spatial statistics, explicitly addressing key challenges faced by climate econometrics. A Bayesian Markov chain Monte Carlo simulation algorithm is derived for model implementation. Using this model, we present the first quantitative assessment of the impacts of extreme heat on global economic production and their scale-dependent spatial processes. Our findings reveal that, at the national scale, economic losses caused by input–output economic linkages initially decline slowly, then drop sharply with increasing connectivity, with an inflection point around 0.1. When accounting for spatial propagation effects, a 1 ℃ increase in extreme heat intensity leads to an average loss of 2.54% [0.90%, 4.19%] of annual GDP per capita—substantially higher than estimates assuming economic losses are locally confined. Moreover, the economic impacts of extreme heat exhibit significant spatial heterogeneity, with positive marginal effects detected in colder regions and negative effects in warmer regions, with a turning point around 33.7 ℃. This study offers a new methodology to evaluate the impact of climate change from a multi-scale and spatial perspective.</div></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"70 19","pages":"Pages 3233-3244"},"PeriodicalIF":21.1,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}