{"title":"D/V Meng Xiang is coming to revive the 60-year-old dream of Moho drilling and enter a new phase of international scientific ocean drilling.","authors":"Yue Xu, Yaoling Niu, Xia Zhang, Tienan Chen, Tingting Wang, Pengyuan Guo, Pu Sun, Xiaohong Wang, Meng Duan, Yanhong Chen","doi":"10.1016/j.scib.2025.02.039","DOIUrl":"https://doi.org/10.1016/j.scib.2025.02.039","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143555430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Science BulletinPub Date : 2025-02-18DOI: 10.1016/j.scib.2025.02.026
Shitong Xiang, Chao Xie, Xiao Xiao, Tobias Banaschewski, Gareth J Barker, Arun L W Bokde, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Rüdiger Brühl, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Jani Penttilä, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Sarah Hohmann, Nathalie Holz, Christian Baeuchl, Michael N Smolka, Nilakshi Vaidya, Henrik Walter, Robert Whelan, Marina Bobou, John Broulidakis, Betteke Maria van Noort, Argyris Stringaris, Zuo Zhang, Lauren Robinson, Jeanne Winterer, Yuning Zhang, Sinead King, Ulrike Schmidt, Julia Sinclair, Sylvane Desrivières, Gunter Schumann, Benjamin Becker, Trevor W Robbins, Tianye Jia, Jianfeng Feng
{"title":"Distinct neural networks of emotional valence and uncertainty in the human amygdala underlying different mental disorders.","authors":"Shitong Xiang, Chao Xie, Xiao Xiao, Tobias Banaschewski, Gareth J Barker, Arun L W Bokde, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Rüdiger Brühl, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Jani Penttilä, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Sarah Hohmann, Nathalie Holz, Christian Baeuchl, Michael N Smolka, Nilakshi Vaidya, Henrik Walter, Robert Whelan, Marina Bobou, John Broulidakis, Betteke Maria van Noort, Argyris Stringaris, Zuo Zhang, Lauren Robinson, Jeanne Winterer, Yuning Zhang, Sinead King, Ulrike Schmidt, Julia Sinclair, Sylvane Desrivières, Gunter Schumann, Benjamin Becker, Trevor W Robbins, Tianye Jia, Jianfeng Feng","doi":"10.1016/j.scib.2025.02.026","DOIUrl":"https://doi.org/10.1016/j.scib.2025.02.026","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Science BulletinPub Date : 2025-02-17DOI: 10.1016/j.scib.2025.02.017
Yu-Xuan Jiao, Guo-Wei Bu, Yun-Wen Wu, Yu-Ke Wu, Bao-Bao Chen, Meng-Ting She, Yi-Hang Zhang, Yu-Jing Lu, Heng-Yu Fan
{"title":"DHX36-mediated G-quadruplexes unwinding is essential for oocyte and early embryo development in mice.","authors":"Yu-Xuan Jiao, Guo-Wei Bu, Yun-Wen Wu, Yu-Ke Wu, Bao-Bao Chen, Meng-Ting She, Yi-Hang Zhang, Yu-Jing Lu, Heng-Yu Fan","doi":"10.1016/j.scib.2025.02.017","DOIUrl":"https://doi.org/10.1016/j.scib.2025.02.017","url":null,"abstract":"<p><p>DHX36 plays a crucial role in regulating transcriptional and post-transcriptional processes through its interaction with G-quadruplexes (G4s). The mechanisms by which DHX36 regulates G4s vary across different cell types and physiological conditions. Oocyte-specific conditional knockout (CKO) mice were utilized to study the impact of DHX36 deficiency on female fertility. The results show that the CKO mice exhibit severely impaired hormone response, ovulation, and complete infertility. The CKO germinal vesicle (GV) oocytes display large nucleoli, aberrant chromatin configuration, decreased chromatin accessibility, disturbed transcriptome, and inhibited meiosis progression. Following fertilization, the embryos derived from the CKO oocytes arrest at the zygote or 2-cell stage. Notably, we observed inadequate rRNA transcription in growing GV oocytes, as well as insufficient pre-rRNA processing and translation activity in fully-grown GV oocytes. Using a G4 probe and antibody, we found increased G4s formation at the chromatin and cytoplasm of CKO GV oocytes; these G4s mainly originate from the rDNA and pre-rRNA. Furthermore, the distribution of DHX36 was found to be spatiotemporally synchronized with that of pre-rRNA and G4s in early mouse embryos. In vitro experiments confirmed that DHX36 directly binds with pre-rRNA through the RHAU-specific motif (RSM). Overexpression of DHX36 could partially alleviate the pre-rRNA accumulation in fully-grown CKO oocytes. In conclusion, this study highlights the physiological significance of DHX36 in maintaining female fertility, underscoring its critical role in rRNA homeostasis and chromatin configuration through G4-unwinding mechanism in mouse oocytes.</p>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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