Science Bulletin最新文献

Intercellular DNA transfer: a hidden consequence of genome instability. 细胞间DNA转移：基因组不稳定的隐藏后果。

IF 20.7 1区综合性期刊

Science Bulletin Pub Date : 2026-10-30 DOI: 10.1016/j.scib.2026.10.070

Xinyu Zhou, Fangwei Wang, Haiyan Yan

引用次数: 0

Chirality-engineered nanozymes orchestrate gut microbiota-host metabolism to shield against cardiotoxicity during cancer chemotherapy via the gut-heart axis 手性工程纳米酶通过肠-心轴协调肠道微生物-宿主代谢，以防止癌症化疗期间的心脏毒性。

IF 20.7 1区综合性期刊

Science Bulletin Pub Date : 2026-10-30 Epub Date: 2026-08-30 DOI: 10.1016/j.scib.2026.08.083

Xiaowan Fan, Shuyu Wang, Yuchen Wang, Shuai Han, Xiaoxi Chen, Yingting Huang, Shanzi Qin, Chengcheng Luo, Ying Wang, Xiyun Yan, Kelong Fan, Shipeng Ning

{"title":"Chirality-engineered nanozymes orchestrate gut microbiota-host metabolism to shield against cardiotoxicity during cancer chemotherapy via the gut-heart axis","authors":"Xiaowan Fan, Shuyu Wang, Yuchen Wang, Shuai Han, Xiaoxi Chen, Yingting Huang, Shanzi Qin, Chengcheng Luo, Ying Wang, Xiyun Yan, Kelong Fan, Shipeng Ning","doi":"10.1016/j.scib.2026.08.083","DOIUrl":"10.1016/j.scib.2026.08.083","url":null,"abstract":"<div><div>Doxorubicin-induced cardiotoxicity remains a critical challenge in cancer chemotherapy, as current strategies rarely balance antitumor efficacy with prevention of systemic side effects. Herein, we develop a chiral amino acid-engineered ruthenium-based nanozyme platform for gut-heart axis-mediated cardioprotection. Systematic screening of 20 amino acids identifies L-Met as the optimal ligand, yielding L-AEN with superior superoxide dismutase- and catalase-like cascade activities and efficient scavenging of ROS and RNS. Chirality engineering further endows L-AEN with markedly enhanced antioxidant performance compared with its D- and DL-counterparts, while maintaining excellent biocompatibility. After enteric encapsulation to form L-AENC, oral administration enables intestinal-targeted release and improves <em>in vivo</em> bioavailability. In a doxorubicin-induced chronic cardiac injury model, L-AENC significantly improves cardiac function, reduces myocardial damage, and suppresses systemic oxidative stress without affecting the antitumor efficacy of doxorubicin. Mechanistically, L-AENC restores gut microbiota homeostasis by enriching beneficial taxa, particularly <em>Muribaculaceae</em>, and reshapes host metabolic profiles, notably involving tryptophan, glutathione, and butyrate metabolism, thereby strengthening gut microbiota-metabolite interactions. Collectively, this work demonstrates that a chirality-engineered nanozyme platform coordinates gut microbiota and host metabolism to protect against chemotherapy-induced cardiotoxicity via the gut-heart axis, highlighting stereochemical engineering as an effective strategy for nanozyme-based therapeutic design.</div></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 20","pages":"Pages 5264-5280"},"PeriodicalIF":20.7,"publicationDate":"2026-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148954627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GeoAI for healthy cities GeoAI健康城市。

IF 20.7 1区综合性期刊

Science Bulletin Pub Date : 2026-10-30 Epub Date: 2026-08-07 DOI: 10.1016/j.scib.2026.08.020

Haoran Ma, Mei-Po Kwan

引用次数: 0

Revisiting the role of genetic variants in the prevention of esophageal squamous cell carcinoma 重新审视遗传变异在预防食管癌中的作用。

IF 20.7 1区综合性期刊

Science Bulletin Pub Date : 2026-10-30 Epub Date: 2026-08-26 DOI: 10.1016/j.scib.2026.08.073

Liyan Zhao, Shao-Hua Xie

引用次数: 0

Corrigendum to “A phospho-switch centered on OsAHL23 orchestrates immune homeostasis in rice” [Sci. Bull. 71(11) (2026) 2701–2705] “以OsAHL23为中心的磷酸化开关协调水稻的免疫稳态”的更正[Sci。牛章71(11)(2026)2701-2705]。

IF 20.7 1区综合性期刊

Science Bulletin Pub Date : 2026-10-30 Epub Date: 2026-08-26 DOI: 10.1016/j.scib.2026.08.066

Zhaotang Ma, Qi He, Haicheng Liao, Junjie Yin, Xiaobo Zhu, Xiang Lu, Li Song, Long Wang, Hai Qing, Yu Fang, Kangjian Niu, Langqing Chen, Yingjie Wei, Jun Xiong, Jiali Liu, Yu Bi, Mawsheng Chern, Yihua Yang, Qingqing Hou, Qing Xiong, Xuewei Chen

引用次数: 0

The musculoskeletal pain-cardiovascular axis: chronic musculoskeletal pain as an underrecognized cardiovascular risk modifier 肌肉骨骼疼痛-心血管轴：慢性肌肉骨骼疼痛作为未被充分认识的心血管风险调节剂。

IF 20.7 1区综合性期刊

Science Bulletin Pub Date : 2026-10-30 Epub Date: 2026-09-09 DOI: 10.1016/j.scib.2026.09.024

Si-Qi Jia, Ming-Xuan Yang, Ting Wu, Liang-Yu Ni, Yi-Nuo Xu, Hong-Lai Cao, Zi-Le He, Yun-Ze Liu, Teng-Yue Gao, Huan Zhang, Qi-Fan Yang, Jiang-Qiong Zhao, Chun-Yu Lu, Jin-Bin Zhang, Bart Morlion, Yun Wang

引用次数: 0

Research progress of chiral organic semiconductors for circularly polarized light detectors 圆偏振光探测器用手性有机半导体研究进展。

IF 20.7 1区综合性期刊

Science Bulletin Pub Date : 2026-10-30 Epub Date: 2026-09-08 DOI: 10.1016/j.scib.2026.09.019

Cuiyun Liu, Ziyi Xie, Qingbin Li, Huanli Dong

{"title":"Research progress of chiral organic semiconductors for circularly polarized light detectors","authors":"Cuiyun Liu, Ziyi Xie, Qingbin Li, Huanli Dong","doi":"10.1016/j.scib.2026.09.019","DOIUrl":"10.1016/j.scib.2026.09.019","url":null,"abstract":"<div><div>Circularly polarized light (CPL) detectors hold great promise for applications in magnetic recording, spin optical communication, biological sensing, and quantum computation. Conventional CPL detectors, which rely heavily on bulky and complex external optical components, struggle to meet the demands of device integration, miniaturization, flexibility, and high efficiency. Notably, chiral organic semiconductors, possessing an intrinsic capability for direct CPL discrimination, along with advantages such as easily tunable properties, solution processability, and intrinsic flexibility, have emerged as promising candidates for CPL detectors. However, the development of chiral organic semiconductors is facing great challenges due to the intrinsic trade-off between charge carrier mobility and absorption dissymmetry factor within these materials. Encouragingly, tremendous efforts have been devoted to resolving this contradiction, contributing to the development of a series of high-performance chiral organic semiconductors. Representative progress is timely summarized from the perspectives of material innovation, device engineering, and advanced applications. Current challenges and emerging opportunities in the field are also discussed. This review aims to establish clear guidelines for the development of chiral organic semiconductors and foster the advancement of high-performance CPL detectors and their application exploration. We hope this review will inspire broad interdisciplinary interest and accelerate progress in the field of chiral optoelectronics.</div></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 20","pages":"Pages 5312-5325"},"PeriodicalIF":20.7,"publicationDate":"2026-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149056677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Household air pollution associated with different heating approaches in rural Northern China 中国北方农村不同供暖方式对家庭空气污染的影响

IF 20.7 1区综合性期刊

Science Bulletin Pub Date : 2026-10-30 Epub Date: 2026-09-09 DOI: 10.1016/j.scib.2026.09.018

Ran Xing, Yatai Men, Yaojie Li, Ke Jiang, Hefa Cheng, Huizhong Shen, Guofeng Shen, Shu Tao

{"title":"Household air pollution associated with different heating approaches in rural Northern China","authors":"Ran Xing, Yatai Men, Yaojie Li, Ke Jiang, Hefa Cheng, Huizhong Shen, Guofeng Shen, Shu Tao","doi":"10.1016/j.scib.2026.09.018","DOIUrl":"10.1016/j.scib.2026.09.018","url":null,"abstract":"<div><div>Household air pollution from solid fuel use remains a major health threat in low- and middle-income regions, yet real-world evidence on affordable transitional energy solutions is limited. While full electrification could eliminate this problem, its high costs remain impractical for the billions who still rely on solid fuels. Here, leveraging China’s Clean Heating Initiative across 948 rural households in the North China Plain, we evaluated pelletized biofuels as a cleaner heating alternative through year-round PM<sub>2.5</sub> monitoring, exposure modeling, and cost-benefit analysis. The annual indoor PM<sub>2.5</sub> concentration was 109 ± 207 μg/m<sup>3</sup>, exceeding WHO guidelines for >90% of the year. Compared with traditional solid fuels, pelletized biofuel use was associated with 20%–30% lower indoor PM<sub>2.5</sub> concentrations, ∼20% lower population exposure, and an estimated 8% lower attributable premature mortality in the study population. The benefit-to-cost ratio ranged from 4.39 to 8.64 for pelletized biofuels, compared with 0.76 to 2.20 for full electrification, with the advantage driven by substantially lower costs. At the regional level, transitioning to pelletized biofuels was estimated to reduce indoor PM<sub>2.5</sub> concentrations and exposure by approximately 10% at a substantially lower cost than electric heating. This study provides large-scale field-based evidence that pelletized biofuels can serve as a cost-effective transitional heating solution for improving indoor air quality, offering actionable insights for other low- and middle-income countries.</div></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 20","pages":"Pages 5302-5311"},"PeriodicalIF":20.7,"publicationDate":"2026-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149056739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “Indistinguishable single photons emitted by blinking-free semiconductor quantum dots in micropillars via δ-doping” [Sci. Bull. 71(12) (2026) 2959–2961] “微柱中无闪烁半导体量子点通过δ掺杂发射的难以区分的单光子”的勘误表[Sci]。牛牛。71(12)(2026)2959-2961]。

IF 20.7 1区综合性期刊

Science Bulletin Pub Date : 2026-10-30 Epub Date: 2026-09-11 DOI: 10.1016/j.scib.2026.09.033

Liang Nie, Jiantao Ma, Shunfa Liu, Wenjing Liu, Ying Yu, Jin Liu, Yun-Feng Xiao

引用次数: 0

Spatial decoupling of electron donation and oxygen capture for efficient endogenous oxygen-driven electrosynthesis of 1O2 in water remediation 水修复中电子给能与氧捕获的空间解耦研究

IF 20.7 1区综合性期刊

Science Bulletin Pub Date : 2026-10-30 Epub Date: 2026-08-26 DOI: 10.1016/j.scib.2026.08.071

Xifeng Lu, Pei Su, Jingxuan Zhao, Xuedong Du, Ge Song, Boxuan Cui, Kexin Chen, Qingrui Zhang, Minghua Zhou

引用次数: 0