Science Bulletin最新文献

{"title":"Greater role of atmospheric circulation than evapotranspiration in reshaping terrestrial moisture recycling","authors":"Jiangpeng Cui , Xu Lian , Ruud J. van der Ent , Luis Gimeno , Diego G. Miralles","doi":"10.1016/j.scib.2025.11.060","DOIUrl":"10.1016/j.scib.2025.11.060","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 8","pages":"Pages 1923-1926"},"PeriodicalIF":21.1,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145877503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Germ layer specification and organotropism in lymphoma invasion","authors":"Yan Dong ,&nbsp;Peng-Peng Xu ,&nbsp;Xiao Han ,&nbsp;Yu-Qing Wang ,&nbsp;Yi Chen ,&nbsp;Ying Fang ,&nbsp;Yue Zhu ,&nbsp;Qing Shi ,&nbsp;Rong Shen ,&nbsp;Zi-Yang Shi ,&nbsp;Niu Qiao ,&nbsp;Shu Cheng ,&nbsp;Yu Liu ,&nbsp;Li Wang ,&nbsp;Mu-Chen Zhang ,&nbsp;Wei-Li Zhao","doi":"10.1016/j.scib.2026.03.009","DOIUrl":"10.1016/j.scib.2026.03.009","url":null,"abstract":"<div><div>Relevance exists between tumorigenesis and embryonic development. Distinct clinical and molecular features, as well as the relationship between the pattern of lymphoma invasion and germ layer development remain largely unknown. We identified a germ layer-dependent specification of extranodal invasion (ENI) in diffuse large B-cell lymphoma. Upon R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) treatment, mesoderm-originating ENI (ENI-mesoderm) was significantly associated with inferior progression-free survival and overall survival, as compared to ectoderm-originating ENI (ENI-ectoderm) and endoderm-originating ENI (ENI-endoderm). Representative oncogenic mutations were <em>MYD88</em>, <em>PIM1</em>, and <em>TBL1XR1</em> in ENI-ectoderm, <em>TP53</em> and <em>TET2</em> in ENI-endoderm, and <em>MYD88</em>, <em>PIM1</em>, <em>TBL1XR1</em>, and <em>CD79B</em> in ENI-mesoderm. Notably, organotrophic migration exhibited temporal disparities corresponding to germ layer development, occurring from ectoderm- to endoderm- and mesoderm-originating organs, with a similar trajectory to the germ layer process. Single-cell RNA sequencing revealed that malignant B cells follow a developmental trajectory mirroring the germ layer process, differentiating from a progenitor state enriched with NF-κB and T-cell activation signaling into two distinct branches by either upregulated B-cell receptor signaling (Path I) or sustained T-cell activation (Path II). Regarding immune checkpoints, ENI-ectoderm, ENI-endoderm, and ENI-mesoderm exhibited significant upregulation of LGALS9, PD-L1, and B7-H3, respectively. Our findings thus contributed to a better understanding of crosstalk between lymphoma progression and embryonic development, providing new insights into targeted approaches against germ layer-dependent invasion in cancer treatment.</div></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 8","pages":"Pages 2055-2069"},"PeriodicalIF":21.1,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147571425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anthropogenic transformation in terrestrial habitats of avian influenza host birds in the 21st century","authors":"Qiang Zhang ,&nbsp;Jinwei Dong ,&nbsp;Zhichao Li ,&nbsp;Xiangming Xiao ,&nbsp;Chuan Yan ,&nbsp;Nanshan You ,&nbsp;Shenglai Yin ,&nbsp;Zhengwang Zhang ,&nbsp;Nyambayar Batbayar ,&nbsp;Keping Ma","doi":"10.1016/j.scib.2025.12.035","DOIUrl":"10.1016/j.scib.2025.12.035","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 8","pages":"Pages 1937-1940"},"PeriodicalIF":21.1,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146027787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An atypical kinase simultaneously enhances grain yield and appearance quality in rice","authors":"Yunzhe Wu ,&nbsp;Qi Wang ,&nbsp;Yun Wang ,&nbsp;Wenzhen Song ,&nbsp;Weishu Fan ,&nbsp;Qiaoling Zhang ,&nbsp;Chenchen Wu ,&nbsp;Jiangyi Zhou ,&nbsp;Laiyuan Zhai ,&nbsp;Jie Hu ,&nbsp;Xueying Liu ,&nbsp;Xiuhua Gao ,&nbsp;Yafeng Ye ,&nbsp;Xiangdong Fu ,&nbsp;Kun Wu","doi":"10.1016/j.scib.2026.01.066","DOIUrl":"10.1016/j.scib.2026.01.066","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 8","pages":"Pages 1903-1906"},"PeriodicalIF":21.1,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146163335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pericyte NNMT drives an immune-hostile vascular niche and restricts cancer immunotherapy","authors":"Sheng Wang ,&nbsp;Geni Ye ,&nbsp;Caiyun Zhang ,&nbsp;Lin Tan ,&nbsp;Zhang Zhang ,&nbsp;Xi Xu ,&nbsp;Xinhui Chen ,&nbsp;Yiming Zhang ,&nbsp;Xiaoling Xu ,&nbsp;Jinghua Pan ,&nbsp;Tong Lan ,&nbsp;Junqiu Zhang ,&nbsp;Changwei Lin ,&nbsp;Dandan Huang ,&nbsp;Xiaobo Li ,&nbsp;Xia Yuan ,&nbsp;Minfeng Chen ,&nbsp;Chenran Wang ,&nbsp;Wencai Ye ,&nbsp;Dongmei Zhang ,&nbsp;Maohua Huang","doi":"10.1016/j.scib.2026.02.001","DOIUrl":"10.1016/j.scib.2026.02.001","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 8","pages":"Pages 1912-1916"},"PeriodicalIF":21.1,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146225070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The E3 ubiquitin ligase MIEL1 promotes thermo-responsive growth by blocking auto-ubiquitination and self-degradation of XBAT31","authors":"Lin-Lin Zhang ,&nbsp;Qiang-Hua Zhou ,&nbsp;Zhi-Ping Deng ,&nbsp;Juan Gao ,&nbsp;Hui-Dan Luo ,&nbsp;Ying-Ying Tian ,&nbsp;Jian-Xiang Liu","doi":"10.1016/j.scib.2026.02.013","DOIUrl":"10.1016/j.scib.2026.02.013","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 8","pages":"Pages 1907-1911"},"PeriodicalIF":21.1,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147346944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Small intracellular vesicles as novel nanocarriers for retinal drug delivery and neuroprotection","authors":"Tong Wang,&nbsp;Meiyan Li,&nbsp;Xingtao Zhou,&nbsp;Luoran Shang","doi":"10.1016/j.scib.2026.03.038","DOIUrl":"10.1016/j.scib.2026.03.038","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 8","pages":"Pages 1856-1858"},"PeriodicalIF":21.1,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147508561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maintained quantity, yet degraded suitability of global croplands from 1990 to 2019","authors":"Ziyue Chen ,&nbsp;Jianqiang Hu ,&nbsp;Chaoqun Zhang ,&nbsp;Bingbo Gao ,&nbsp;Manchun Li ,&nbsp;Jing Yang ,&nbsp;Yuxue Wang ,&nbsp;Zhaozhong Feng ,&nbsp;Baojing Gu","doi":"10.1016/j.scib.2026.02.027","DOIUrl":"10.1016/j.scib.2026.02.027","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 8","pages":"Pages 1927-1931"},"PeriodicalIF":21.1,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147324308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urban air conditioning is combating self-made island effects","authors":"Xiaoxue Kou ,&nbsp;Primož Poredoš ,&nbsp;Ruzhu Wang","doi":"10.1016/j.scib.2026.03.039","DOIUrl":"10.1016/j.scib.2026.03.039","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 8","pages":"Pages 1866-1870"},"PeriodicalIF":21.1,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147508474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linear zigzag covalent organic frameworks diminish thermal relaxation and exciton dissociation energy in photoelectrocatalysis","authors":"Boying Zhang ,&nbsp;Zhenshou Zhang ,&nbsp;Yushan Wang ,&nbsp;Qiaoling Guo ,&nbsp;Qing Li ,&nbsp;Haining Liu ,&nbsp;Shanlin Qiao","doi":"10.1016/j.scib.2026.03.014","DOIUrl":"10.1016/j.scib.2026.03.014","url":null,"abstract":"<div><div>Two-dimensional/three-dimensional imine-based covalent organic frameworks (2D/3D imine-based COFs) face dual bottlenecks in photoelectrochemical (PEC) applications from both intrinsic limitations in charge transport caused by polarized imine bonds and extrinsic barriers to solution-based fabrication of devices. Herein, we overcome both challenges through the dimension-induced carrier optimization strategy by engineering a solution-processable, highly crystalline one-dimensional (1D) zigzag porous COF (1D-COF_CDBA). Its structure inherently bypasses the fundamental electronic constraints while enabling scalable thin-film fabrication. The dual-chain interlocking architecture of the 1D-COF_CDBA suppresses molecular vibration and rotation, resulting in a lower exciton binding energy (37.2 meV) compared to the 2D counterpart (41.0 meV). 1D-COF_CDBA provides an ultralow in-plane electron effective mass for directional charge transport. Consequently, the 1D-ECOF_CDBA photocathode achieves a photocurrent density 1.8 times higher than that of the 2D-ECOF_BCTB at 0.4 V vs. RHE. The solution-processable 1D-ECOF_CDBA nanorods enable direct fabrication of panel photoelectrodes via spin-coating, enabling the realization of high-integrity P3HT/1D-ECOF_CDBA-C₆₀/TiO₂ heterojunction photoelectrodes. This architecture demonstrates a remarkable photocurrent density difference of 147 μA cm⁻² between illuminated and dark conditions at 0.4 V vs. RHE. By implementing dimensionality engineering, this work successfully decouples the processability‒charge dynamics trade-off, paving the way for high-performance organic semiconductors in energy applications.</div></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 8","pages":"Pages 1993-2002"},"PeriodicalIF":21.1,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147508499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}