Science Bulletin最新文献

{"title":"Community prevention and standardized clinical treatment jointly improve cancer outcome: Real-world evidence from an esophageal cancer patient cohort study.","authors":"Ji Ke, Fangfang Liu, Wei Yang, Ruiping Xu, Lei Chen, Wenlei Yang, Yu He, Zhen Liu, Bolin Hou, Liqun Zhang, Miaoping Lin, Lixin Zhang, Fan Zhang, Fen Cai, Huawen Xu, Mengfei Liu, Ying Liu, Yaqi Pan, Zhonghu He, Yang Ke","doi":"10.1016/j.scib.2024.11.005","DOIUrl":"https://doi.org/10.1016/j.scib.2024.11.005","url":null,"abstract":"<p><p>Extensive efforts have been put into reducing the heavy burden of esophageal squamous cell carcinoma (ESCC) in China. However, the joint impact of prevention and treatment on the long-term overall survival (OS) of ESCC patients remains largely unknown. We consecutively recruited 13,255 ESCC patients from two Chinese centers: the Northern center, located in a high-risk area with abundant screening programs; and the Southern center, situated in a non-high-risk area with improved clinical practices. Inter-center comparison, longitudinal intra-center comparison, and a simulation analysis were conducted to investigate the influence of tumor downstaging and high-quality clinical treatment on OS. During a follow-up period of 12.52 years, the Northern center exhibited higher median survival than the Southern center (6.22 vs. 3.15 years; HR_adjusted = 0.73, 95% CI: 0.69-0.77). Mediation analysis demonstrated that its OS advantage was largely (77.7%) attributed to earlier TNM stage (stage 0-II: 51.3% vs. 24.6%). In temporal analyses, patient survival in the Southern center gradually improved (median survival during 2015-2018 vs. 2009-2014: 3.58 vs. 2.93 years; HR_adjusted = 0.86, 95% CI: 0.79-0.94), coinciding with the progress of treatment-related indices (completeness of TNM staging in discharge diagnosis [from 53.7% to 99.6%], adoption of minimally invasive esophagectomy [from 0.0% to 51.1%] and right thoracic esophagectomy [from 12.4% to 86.4%], etc.). Simulation analysis further demonstrated that integrating both downstaging and high-quality treatment would lead to the best survival. Tumor downstaging and high-quality clinical treatment have a joint impact on ESCC patient survival. Establishing a comprehensive strategy that integrates cancer prevention with optimal clinical treatment is crucial for alleviating the ESCC burden.</p>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shifting agricultural land use and its unintended water consumption in the North China Plain.","authors":"Liang Dong, Di Long, Caijin Zhang, Yingjie Cui, Yanhong Cui, Yiming Wang, Luoqi Li, Zhongkun Hong, Ling Yao, Jinling Quan, Liangliang Bai, Hao Wang, Bridget R Scanlon","doi":"10.1016/j.scib.2024.11.009","DOIUrl":"https://doi.org/10.1016/j.scib.2024.11.009","url":null,"abstract":"<p><p>Agricultural land use (ALU) critically influences food production and water resource allocation. This study examines the dynamics of ALU in the North China Plain (NCP), a region characterized by intensive agriculture and severe groundwater over-exploitation, focusing on the multidimensional drivers and their implications for water resource management. By employing an elaborate classification scheme based on satellite imagery and extensive first-hand field data, we identified significant shifts in crop patterns. From 2013 to 2017, there was a notable transition from double crops (primarily wheat-maize) to single crops (primarily maize), covering 4600 km² and accounting for 42% of single crops in 2013. From 2017 to 2022, there was a shift from single crops to economic forests, encompassing 3600 km² and 22% of economic forests in 2017, including orchards, timber trees, and shelter forest belts. These shifts resulted in an 11% decrease in grain acreage (6800 km²) but an 11% increase in crop water consumption (6.3 km³) during 2013-2022. Notably, water consumption by economic forests increased by 126% (9.4 km³) during this period. This study highlights the critical need to balance competing demands for food and water security, providing valuable insights applicable to other agriculturally intensive regions worldwide.</p>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142643329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Restoring sweat gland function in mice using regenerative sweat gland cells derived from chemically reprogrammed human epidermal keratinocytes.","authors":"Jiangbing Xiang, Huating Chen, Hongliang Zhang, Lu Wu, Yan Li, Shuaifei Ji, Wei Pi, Shaoyuan Cui, Lei Dong, Xiaobing Fu, Xiaoyan Sun","doi":"10.1016/j.scib.2024.11.003","DOIUrl":"https://doi.org/10.1016/j.scib.2024.11.003","url":null,"abstract":"<p><p>The regeneration of sweat glands (SwGs) plays a pivotal role in the functional recovery of extensive skin wounds. Recent research has illuminated the possibility of reprogramming human epidermal keratinocytes (HEKs) into induced SwG cells through the ectopic expression of ectodysplasin A. However, the clinical application of this genetic manipulation approach is inherently limited. In this study, we present findings demonstrating that a combination of six compounds can effectively and speedily reprogram HEKs in culture into fully functional SwG cells. These chemically induced SwG-like cells (ciSGCs) closely resemble the morphology, phenotypes, and functional properties of human primary SwG ductal cells. Furthermore, ciSGCs can be stimulated to differentiate into mature SwG cell types in vitro. In a 3D culture system, they can also generate SwG organoids that exhibit structural and biological features akin to native SwGs. Upon transplantation into scalded mouse paw skin, ciSGCs significantly expedited cutaneous wound healing and completely restored the structural and functional aspects of the SwGs. In conclusion, the small molecule cocktail-directed SwG reprogramming offers a non-transgenic and controllable strategy for producing high-quality, clinical-grade SwG cells, showing immense potential for the treatment of burn patients.</p>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142643678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A facile route to synthesize cubic gauche polymeric nitrogen.","authors":"Runteng Chen, Jun Zhang, Zelong Wang, Ke Lu, Yi Peng, Jianfa Zhao, Xiaodong Liu, Shaomin Feng, Ruibin Liu, Chuan Xiao, Changqing Jin","doi":"10.1016/j.scib.2024.11.004","DOIUrl":"https://doi.org/10.1016/j.scib.2024.11.004","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intratumoral lactic acid neutralization strategy for boosting chemoimmunotherapy using liposomal sodium bicarbonate.","authors":"Taoxing Peng, Xinyue Shao, Wenqin Song, Weihua Xu, Wei Xiong, Yihao He, Yang Ding, Yongzhuo Huang","doi":"10.1016/j.scib.2024.08.042","DOIUrl":"https://doi.org/10.1016/j.scib.2024.08.042","url":null,"abstract":"<p><p>Glycolysis-related lactic acid overproduction creates an \"ion-trapping\" barrier and immunosuppressive tumor microenvironment that compromise effective intratumoral drug delivery and therapy. Therefore, normalization of tumor microenvironment via lactic acid neutralization can be a promising avenue for overcoming this therapeutic hurdle. In this study, the flexible liposomes loaded with sodium bicarbonate (NaHCO₃@Flip) were used as a nano-adjuvant to boost chemoimmunotherapy. Their effects on assisting DOXIL and anti-programmed cell death protein 1 (PD-1) therapy were investigated. NaHCO₃@Flip achieved deep tumor penetration, with the ability to neutralize lactic acid and normalize the acidic tumor microenvironment. NaHCO₃@Flip is biosafe and can enhance cellular uptake efficiency of doxorubicin (DOX) by overcoming the ion-trapping barrier and amplify immunogenic cell death induced by DOX. The combination therapy of liposomal DOX and NaHCO₃@Flip demonstrated enhanced inhibition of tumor growth. NaHCO₃@Flip can also synergize with PD-1 antibody therapy. NaHCO₃@Flip has the potential to serve as a therapeutic adjuvant for boosting chemoimmunotherapy by overcoming the ion-trapping effect and normalizing the tumor microenvironment.</p>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urine multi-omics markers to predict seizure one day in advance.","authors":"Wanlin Lai, Leihao Sha, Rui Li, Shan Yu, Ling Jin, Ruiqi Yang, Chao Yang, Lei Chen","doi":"10.1016/j.scib.2024.10.035","DOIUrl":"https://doi.org/10.1016/j.scib.2024.10.035","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In situ synthetic C encapsulated δ-MnO₂ with O vacancies: A versatile programming in bio-engineering.","authors":"Wei Lv, Zilei Shen, Junlin Liu, Xudong Li, Fang Ding, Dongyue Zhang, Licheng Miao, Xuefeng Lyu, Ruijie Li, Miaomiao Wang, Yiming Li, Jingwen Meng, Chao Xu","doi":"10.1016/j.scib.2024.10.034","DOIUrl":"https://doi.org/10.1016/j.scib.2024.10.034","url":null,"abstract":"<p><p>In this study, we successfully synthesized a δ-MnO₂ cathode with O vacancies, encapsulated by C derived from pyromellitic acid, using a facile hydrothermal method followed by annealing in an Ar atmosphere. The cathode's structural stability and charge transfer kinetics are enhanced by inhibiting the formation of the by-product Zn₄SO₄(OH)₆·4H₂O, regulating the Mn valence state, and suppressing the Jahn-Teller effect through the synergy of C encapsulation and O vacancies. This results in remarkable electrochemical performance, including a large capacity of 421.2 mAh g^-1 at 0.1 A g^-1, a high specific energy density of 595.53 Wh kg^-1, and exceptional long-cycle life stability with 90.88% over 4000 cycles at 10 A g^-1, together with superior coulombic efficiency (∼100%) in pure ZnSO₄ electrolyte. Moreover, the cathode materials demonstrate specific antitumor efficacy. In brief, this work introduces an in situ synthetic C encapsulated δ-MnO₂ with O vacancies expected to be applied in both large-scale energy storage and biomedicine.</p>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142643677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tunable refractive index transparent conductive adhesives for efficient monolithic tandem solar cells.","authors":"Xingliang Li, Sanlong Wang, Xiangqing Zhou, Yucheng Li, Hui Liu, Biao Shi, Qiang Sun, Ying Zhao, Xiaodan Zhang","doi":"10.1016/j.scib.2024.10.033","DOIUrl":"https://doi.org/10.1016/j.scib.2024.10.033","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging brain white matter function using resting-state functional MRI.","authors":"Gong-Jun Ji, Zaixu Cui, Ryan C N D'Arcy, Wei Liao, Bharat B Biswal, Qing Zhang, Cheng Luo, Yu-Feng Zang, Zhaohua Ding, Xi-Nian Zuo, John C Gore, Kai Wang","doi":"10.1016/j.scib.2024.11.001","DOIUrl":"https://doi.org/10.1016/j.scib.2024.11.001","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vivo self-assembled bispecific fluorescence probe for early detection of bladder cancer and metastasis.","authors":"Da-Yong Hou, Ni-Yuan Zhang, Peng Zhang, Xiang-Peng Li, Jiong-Cheng Wu, Mei-Yu Lv, Zhi-Jia Wang, Xing-Jie Hu, Jian-Xiao Liang, Hong-Lei Wang, Yue-Ze Wang, Hui-Hui You, Hong-Wei An, Hao Wang, Wanhai Xu","doi":"10.1016/j.scib.2024.10.032","DOIUrl":"https://doi.org/10.1016/j.scib.2024.10.032","url":null,"abstract":"<p><p>Tumor metastasis accounts for over 90% of tumor-related deaths, prompting the development of fluorescently labeled tumor-specific molecular imaging agents for differentiating tumors from normal tissues. However, early detection of metastasis lesions by tracking tumor markers alone has proven to be challenging. Herein, we reported a glycopeptide-based bispecific fluorescence probe (bsProbe) for earlier detection of bladder cancer and metastasis. By simultaneously recognition (tumor & tumor microenvironment) and in vivo self-assembly, the tumor accumulation of bsProbe (12.3% ID/g) was obviously increased by ∼6 fold compared with that in CXCR4 specific fluorescence probe (sProbe), indicating the obvious advantages of bsProbe over existing tumor metastasis detection probes. Additionally, bsProbe substantially broadens the tumor diagnosis window and enhances the detection signal to noise ratio (SNR: approximately 9.5), permitting early diagnosis of lung micro-metastasis (∼1 mm), precise identifying of tumor boundaries and micro-tumors in orthotopic tumor models. More importantly, bsProbe was demonstrated to distinguish malignant from benign specimen with a specificity of 90.48% and sensitivity of 92.22% in 195 clinical specimens of bladder cancer patients. Taken together, this novel synergetic targeting (CD206 × CXCR4) strategy provides an attractive method for earlier detection of bladder cancer and metastasis, which might be further extended to the imaging-guided surgery of clinical invisible tumors.</p>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}