Science Bulletin最新文献

The glymphatic system in psychiatric disorders: a new perspective. 精神疾病中的淋巴系统：一个新的视角。

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2025-05-09 DOI: 10.1016/j.scib.2025.05.015

Teng Gao, Zhe Wang, Serik Tabarak, Qingqing Yin, Lin Lu

引用次数: 0

FuHsi regulates rDNA transcription and promotes tumor progression. 复喜调节rDNA转录，促进肿瘤进展。

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2025-05-09 DOI: 10.1016/j.scib.2025.04.068

Xiaohui Yang, Ao Ding, Songzhe Wu, Ziyue Jiang, Yifei Li, Xianting Huang, Liqiang Duan, Shuwen Cheng, Shizhong Zheng, Shan Gao

引用次数: 0

CGMMV capsid protein hijacks host pro-viral factors to generate condensates and remodel photosynthesis: strategic antiviral protocol. CGMMV衣壳蛋白劫持宿主前病毒因子产生凝聚物并重塑光合作用：战略性抗病毒方案

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2025-05-09 DOI: 10.1016/j.scib.2025.05.012

Limin Yin, Xiangyang Li, Chunni Zhao, Runjiang Song, Baoan Song

引用次数: 0

Facilitating efficient catalytic conversion of polysulfides in lithium-sulfur batteries via self-assembled hydrogen-bond-rich covalent organic frameworks. 通过自组装富氢键共价有机框架促进锂硫电池中多硫化物的高效催化转化。

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2025-05-08 DOI: 10.1016/j.scib.2025.05.005

Yang Shi, Shun Wang, Peiyu Cui, Jiacheng Ma, Xingxing Zhang, Zhuo Chen, Xuehan Hou, Xiao Li, Xilang Jin, Yanan Zhang, Yaoyu Wang, Wenhuan Huang

{"title":"Facilitating efficient catalytic conversion of polysulfides in lithium-sulfur batteries via self-assembled hydrogen-bond-rich covalent organic frameworks.","authors":"Yang Shi, Shun Wang, Peiyu Cui, Jiacheng Ma, Xingxing Zhang, Zhuo Chen, Xuehan Hou, Xiao Li, Xilang Jin, Yanan Zhang, Yaoyu Wang, Wenhuan Huang","doi":"10.1016/j.scib.2025.05.005","DOIUrl":"https://doi.org/10.1016/j.scib.2025.05.005","url":null,"abstract":"The widespread commercialization of lithium-sulfur (Li-S) batteries is hindered by two critical challenges: sluggish redox kinetics and the detrimental polysulfide shuttle effect. In this study, we present a novel approach utilizing hydrogen-bond-rich covalent organic frameworks (TTP@PVDF50), synthesized through an in situ self-assembly process incorporating polymeric guest species. These covalent organic frameworks (COFs), when integrated into the separators of Li-S batteries, preserve their intrinsic porosity and crystallinity, while the abundant fluorine-rich sites and well-defined pore structures enhance lithium-ion (Li+) transport kinetics. The hydrogen-bond-rich nature of the COFs provides an effective strategy to mitigate the polysulfide shuttle, leveraging both spatial hindrance and strong polar interactions for enhanced adsorption. Density functional theory (DFT) calculations and in situ Raman spectroscopy reveal that the F∙∙∙OH hydrogen bonding network in the TTP@PVDF50 composite significantly accelerates Li+ migration and catalyzes the conversion of LiPSs. The modified separator demonstrates a high discharge capacity of 1420.2 mAh g-1 at 0.2 C (1 C=1675 mAh g-1), alongside remarkable anti-self-discharge performance with only 9.0% capacity loss. Notably, the Li-S battery with a high sulfur loading (4.59 mg cm-2) and a lean electrolyte (6 µL mg-1) retains over 83% of its capacity, underscoring the effectiveness of this strategy in advancing the performance and longevity of Li-S batteries.","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular architecture and inhibition mechanism of human ATR-ATRIP. 人ATR-ATRIP的分子结构及抑制机制。

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2025-05-06 DOI: 10.1016/j.scib.2025.05.009

Guangxian Wang, Po Wang, Zexuan Zheng, Qingjun Zhang, Chenchen Xu, Xinyi Xu, Lingfei Jian, Zhanpeng Zhao, Gang Cai, Xuejuan Wang

{"title":"Molecular architecture and inhibition mechanism of human ATR-ATRIP.","authors":"Guangxian Wang, Po Wang, Zexuan Zheng, Qingjun Zhang, Chenchen Xu, Xinyi Xu, Lingfei Jian, Zhanpeng Zhao, Gang Cai, Xuejuan Wang","doi":"10.1016/j.scib.2025.05.009","DOIUrl":"https://doi.org/10.1016/j.scib.2025.05.009","url":null,"abstract":"The ataxia telangiectasia-mutated and Rad3-related (ATR) kinase is a master regulator of DNA damage response and replication stress in humans. Targeting ATR is the focus of oncology drug pipelines with a number of potent, selective ATR inhibitors currently in clinical development. Here, we determined the cryo-EM structures of the human ATR-ATRIP complex in the presence of VE-822 and RP-3500, two ATR inhibitors currently in Phase II clinical trials, achieving an overall resolution of approximately 3 Å. These structures yield a near-complete atomic model of the ATR-ATRIP complex, revealing subunit stoichiometry, intramolecular and intermolecular interactions, and critical regulatory sites including an insertion in the PIKK regulatory domain (PRD). Structural comparison provides insights into the modes of action and selectivity of ATR inhibitors. The divergent binding modes near the solvent side and in the rear pocket area of VE-822 and RP-3500, particularly their disparate binding orientations, lead to varying conformational changes in the active site. Surprisingly, one ATR-ATRIP complex binds four VE-822 molecules, with two in the ATR active site and two at the ATR-ATR dimer interface. The binding and selectivity of RP-3500 depend on two bound water molecules, which may be further enhanced by the substitution of these bound waters. Our study provides a structural framework for understanding ATR regulation and holds promise for assisting future efforts in rational drug design targeting ATR.","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144085595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nitrate wastewater regeneration in coastal arid region. 沿海干旱区硝酸盐废水再生研究。

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2025-05-05 DOI: 10.1016/j.scib.2025.05.004

Xia Zhang, Solmaz Feizpoor, Muhammad Humayun, Xianbiao Fu, Chundong Wang

引用次数: 0

Putting the recent 100-year of Asian summer monsoon weakening into context. 把近100年的亚洲夏季风减弱置于背景中。

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2025-05-05 DOI: 10.1016/j.scib.2025.05.006

Jingyao Zhao, Hai Cheng, Liangkang Pan, Kexin Wang, Jiahui Cui, Ming-Qiang Liang, Xiyu Dong, Jiayu Lu, Qiang Li, Yan Yang

引用次数: 0

Electrochemical β-selective silylcarboxylation of styrenes with CO₂. 苯乙烯与CO2的电化学β选择性硅基羧基化反应。

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2025-05-05 DOI: 10.1016/j.scib.2025.05.002

Pengfei Xie, Anzai Shi, Youai Qiu

引用次数: 0

The Tibetan Plateau acts as a net greenhouse gas sink. 青藏高原是温室气体的净汇。

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2025-05-05 DOI: 10.1016/j.scib.2025.05.001

Tao Wang, Xinhui Ji, Jianjun Wei, Guanting Lyu, Jinfeng Chang, Xiaoyi Wang, Yilong Wang, Guoqing Zhang, Lijun Zuo, Yuanyi Gao, Shushi Peng, Xiangjun Tian, Xuhui Wang, Shilong Piao

{"title":"The Tibetan Plateau acts as a net greenhouse gas sink.","authors":"Tao Wang, Xinhui Ji, Jianjun Wei, Guanting Lyu, Jinfeng Chang, Xiaoyi Wang, Yilong Wang, Guoqing Zhang, Lijun Zuo, Yuanyi Gao, Shushi Peng, Xiangjun Tian, Xuhui Wang, Shilong Piao","doi":"10.1016/j.scib.2025.05.001","DOIUrl":"https://doi.org/10.1016/j.scib.2025.05.001","url":null,"abstract":"The greenhouse gas budget on the Tibetan Plateau remains unknown and the potential for methane (CH4) and nitrous oxide (N2O) emissions from an intensifying livestock system and expanding surface water in offsetting terrestrial carbon dioxide (CO2) sinks are both of great concerns and uncertainties, which compromise an accurate assessment of Tibetan Plateau contribution to China's ambitious climate goals by 2060s. Here we integrated greenhouse gas flux measurements at ∼500 sites in empirical modeling approaches, emissions from the livestock sector with process-based biogeochemistry modeling to estimate CH4 and N2O fluxes across terrestrial ecosystems and inland waters in 2000s and 2010s. We found that emissions from livestock and inland waters, predominantly contributed by CH4, compensated ∼21% and ∼13% of carbon sinks provided by forests and grasslands after adjusting carbon burial in sediments and riverine carbon export, respectively. The Tibetan Plateau then acted as an appreciable greenhouse gas sink that almost compensated for its contemporary anthropogenic emissions, making it nearly climate-neutral. The enhancement of terrestrial CO2 sinks in the 2060s under medium warming scenario would be counterbalanced by livestock CH4 emissions when the current overgrazing status continues. By transitioning to a livestock-forage balance and implementing mitigation initiatives to reduce livestock emission intensity, the greenhouse gas sink is projected to increase by more than 1.5 times. We suggested that a transition towards sustainable pastoralism illuminates the path to minimizing ecosystem greenhouse gas emissions and amplifying the role of the Tibetan Plateau in fulfilling China's climate ambition.","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144085597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emergence of nodal-knot transitions by disorder. 由无序引起的节结转换的出现。

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2025-05-02 DOI: 10.1016/j.scib.2025.04.061

Ming Gong, Peng-Lu Zhao, Hai-Zhou Lu, Qian Niu, X C Xie

引用次数: 0