Science Bulletin最新文献_第10页

A wearable accelerometry landscape of human health and disease. 人类健康和疾病的可穿戴加速计景观。

IF 20.7 1区综合性期刊

Science Bulletin Pub Date : 2026-09-22 DOI: 10.1016/j.scib.2026.09.066

Ying Liang, Yujia Zhao, Yueting Deng, Yuzhu Li, Yueming Xu, Yilin Chen, Xihan Cui, Zeyu Li, Yanting Wu, Barbara J Sahakian, Wanting He, Jianfeng Feng, Jintai Yu, Jia You, Wei Cheng

{"title":"A wearable accelerometry landscape of human health and disease.","authors":"Ying Liang, Yujia Zhao, Yueting Deng, Yuzhu Li, Yueming Xu, Yilin Chen, Xihan Cui, Zeyu Li, Yanting Wu, Barbara J Sahakian, Wanting He, Jianfeng Feng, Jintai Yu, Jia You, Wei Cheng","doi":"10.1016/j.scib.2026.09.066","DOIUrl":"https://doi.org/10.1016/j.scib.2026.09.066","url":null,"abstract":"Digital wearable devices provide objective characterization of human behaviors in real-world settings, yet their implications for health and diseases remain incompletely understood. Here, we analyzed a large-scale accelerometry-based cohort, including 70,473 participants with up to 10 years of follow-up, yielding a total of 11.8 million person-hours of data. From this cohort, we constructed a comprehensive atlas of 210 accelerometer-derived phenotypes (ADPs), encompassing physical activity, sedentary behavior, sleep, circadian rhythm, step counts, and step intensity. The study identified 8149 ADP-disease and 36,614 ADP-trait associations across 406 diseases and 956 health-related traits. Step intensity and circadian rhythm emerged as the most prominent ADP domains associated with diseases. In addition, we developed an artificial intelligence (AI) framework, named Wearable-Accelerometry-based Temporal-Structural Network (WATSNet), achieving high discrimination (AUC >0.7) for 112 (28.1%) incident and 65 (34.0%) prevalent diseases, e.g., incidence of Parkinson's disease (AUC = 0.873) and dementia (AUC = 0.841). We provided evidence-informed behavioral benchmarks associated with lower disease risks: at least 0.8 h per day of moderate-to-vigorous physical activity, 10,000 daily steps, and 7.8 h of sleep per day. Furthermore, we evaluated the generalizability of both ADP-disease associations and the performance of WATSNet in an external dataset (n = 4406). Together, these findings provide a comprehensive landscape linking digital behaviors to diverse health outcomes (https://digital-phenome-atlas.com) and a foundation for precision health monitoring.","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":20.7,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149102354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reimagining landslides: from geo-hazards to earth-surface system drivers. 重新想象滑坡：从地质灾害到地表系统驱动因素。

IF 20.7 1区综合性期刊

Science Bulletin Pub Date : 2026-09-22 DOI: 10.1016/j.scib.2026.09.061

Yanjun Shen, Jinyu Zhu, Jianbing Peng

引用次数: 0

NoPro-clipping reveals a hidden universe of ubiquitinated glycogen and metabolites. nopro剪切揭示了一个隐藏的泛素化糖原和代谢物的宇宙。

IF 20.7 1区综合性期刊

Science Bulletin Pub Date : 2026-09-22 DOI: 10.1016/j.scib.2026.09.062

Chuntong Li, Lu-Jun Liang

引用次数: 0

Active bacteria-delivered nanosystems for multimodal bladder cancer therapy. 活性细菌递送纳米系统用于多模式膀胱癌治疗。

IF 20.7 1区综合性期刊

Science Bulletin Pub Date : 2026-09-22 DOI: 10.1016/j.scib.2026.09.064

Tianze Du, Yaoguang She, Hongzhao Li, Xinting Liu, Yuhan Zhang, Yulu Hu, Ruiyan Li, Yijing Zhang, Li Wang, Yong Kang, Xiaoyuan Ji

引用次数: 0

T-linear specific heat in pressurized and magnetized Shastry-Sutherland Mott insulator SrCu₂(BO₃)₂. 加压磁化Shastry-Sutherland Mott绝缘体SrCu2（BO3）的t -线性比热

IF 20.7 1区综合性期刊

Science Bulletin Pub Date : 2026-09-22 DOI: 10.1016/j.scib.2026.09.060

Jing Guo, Pengyu Wang, Cheng Huang, Chengkang Zhou, Wenshan Hong, Menghan Song, Xintian Chen, Ting-Tung Wang, Shu Cai, Jinyu Zhao, Jinyu Han, Yazhou Zhou, Qi Wu, Shiliang Li, Zi Yang Meng, Liling Sun

引用次数: 0

Interfacial carbon vacancy stabilized ruthenium oxide for efficient acidic oxygen evolution. 界面碳空位稳定氧化钌的高效酸性析氧。

IF 20.7 1区综合性期刊

Science Bulletin Pub Date : 2026-09-22 DOI: 10.1016/j.scib.2026.09.063

Tianyi Gao, Qiwen Su, Yajing Mu, Dongxu Jiao, Lina Wang, Yang Yi, Xinjing Liu, Mingming Wang, Zhipeng Feng, Lei Zhang, Xiaoxin Zou, Weitao Zheng, Xiao Zhao, David J Singh, Jinchang Fan, Xiaoqiang Cui

{"title":"Interfacial carbon vacancy stabilized ruthenium oxide for efficient acidic oxygen evolution.","authors":"Tianyi Gao, Qiwen Su, Yajing Mu, Dongxu Jiao, Lina Wang, Yang Yi, Xinjing Liu, Mingming Wang, Zhipeng Feng, Lei Zhang, Xiaoxin Zou, Weitao Zheng, Xiao Zhao, David J Singh, Jinchang Fan, Xiaoqiang Cui","doi":"10.1016/j.scib.2026.09.063","DOIUrl":"https://doi.org/10.1016/j.scib.2026.09.063","url":null,"abstract":"Advancement of proton exchange membrane water electrolyzers (PEMWEs) requires the development of high-performance catalysts for the anode acidic oxygen evolution reaction (OER), particularly RuOx-based catalysts. However, practical applications have been hindered by poor stability, resulting from excessive oxygen leaching and severe RuOx agglomeration. Here, we report an interfacial carbon vacancy confined strategy to stabilize active RuOx nanoparticles on titanium carbide supports (TiCx), delivering a mass activity of 1095.4 A g-1Ru at 1.47 V vs. the reversible hydrogen electrode (RHE), outperforming most reported RuOx-based electrocatalysts, while maintaining stable operation over 600 h at 10 mA cm-2. In-situ spectroscopic analyses, combined with theoretical calculations, reveal that the TiCx support reduces the overlap between Ru 4d and O 2p orbitals, thereby suppressing lattice oxygen reactivity and inhibiting the involvement of the detrimental lattice oxygen mechanism. Identical location transmission electron microscopy and molecular dynamics simulation demonstrate that carbon vacancies induce strong catalyst-support interactions, effectively maintaining well-dispersed RuOx nanoparticles without agglomeration during the OER. Importantly, the assembled PEMWE employing the as-prepared RuOx/TiCx catalyst achieves a low cell voltage of 1.61 V at 1 A cm-2 and high durability for over 200 h at 200 mA cm-2. This interfacial vacancy confinement strategy provides an effective approach for designing highly durable electrocatalysts for practical applications.","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":20.7,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From DNA packaging material to epigenetic information carrier: remembering the landmark 1996 histone studies in Tetrahymena. 从DNA包装材料到表观遗传信息载体：回顾1996年具有里程碑意义的四膜虫组蛋白研究。

IF 20.7 1区综合性期刊

Science Bulletin Pub Date : 2026-09-18 DOI: 10.1016/j.scib.2026.09.059

Xingyin Liu, Moustapha Hassan

引用次数: 0

Impaired splicing of a conserved Pcyt2 minor intron in specific neuroglia contributes to spinal muscular atrophy. 特定神经胶质细胞中保守Pcyt2小内含子剪接受损导致脊髓性肌萎缩。

IF 20.7 1区综合性期刊

Science Bulletin Pub Date : 2026-09-18 DOI: 10.1016/j.scib.2026.09.055

Ni Long, Hui-Yi Zhao, An-Min Liang, Yan-Ran Meng, Ling-Kun Xie, Guo-Dong Xu, Conglin Su, Boshuo Zhou, Xinting Cai, Yuhan Zhang, Zhentao Zhang, Jing Yao, Yu-Jie Fan, Yong-Zhen Xu

引用次数: 0

A giant peanut-shaped ultra-high-energy γ-ray emitter off the galactic plane. 一个巨大的花生形状的超高能γ射线发射器。

IF 20.7 1区综合性期刊

Science Bulletin Pub Date : 2026-09-18 DOI: 10.1016/j.scib.2026.09.046

{"title":"A giant peanut-shaped ultra-high-energy γ-ray emitter off the galactic plane.","authors":"","doi":"10.1016/j.scib.2026.09.046","DOIUrl":"https://doi.org/10.1016/j.scib.2026.09.046","url":null,"abstract":"Ultra-high-energy (UHE) gamma (γ) rays serve as unique probes for investigating new non-thermal astronomical phenomena within the Galaxy and also for studying PeV particle acceleration and propagation. Based on the UHE γ-ray survey conducted by LHAASO, this paper reports the discovery of a new source distinct from all previously identified high energy γ-ray objects. This source exhibits an elongated, peanut-like structure, which can be described as a rectangular strip measuring 4.6° in length and 0.45° in width, featuring two bright knots. It is located at a Galactic latitude of -17.5°, well below the Galactic plane and away from regions rich in UHE sources. The energy spectrum is spatially uniform across the entire region and is well fitted by a power-law model with an index of -1.95 and a cutoff at 250 TeV. The highest detected photon energy reaches 760 TeV. Morphological and spectral analyses indicate the presence of a powerful particle accelerator in this region, capable of accelerating particles beyond 1 PeV. An energetic millisecond pulsar (MSP) J0218 + 4232 is located at the brighter end of this source, with a spatial chance coincidence probability of 3.6 × 10-4, corresponding to 3.4σ. This suggests that the emission from this region very likely originates from particles accelerated within the MSP wind nebulae, potentially providing the first observational evidence supporting the wind nebulae of MSP as sources of UHE γ rays. However, the presence of other hidden accelerators, whether associated with known or entirely new populations of PeVatrons, cannot be ruled out, motivating future multi-wavelength observations.","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":20.7,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149206272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing interfacial stability of high-voltage LiCoO₂ via fabricating a front-face with confined channels for desolvation. 通过制造具有受限溶解通道的前表面来增强高压LiCoO2的界面稳定性。

IF 20.7 1区综合性期刊

Science Bulletin Pub Date : 2026-09-18 DOI: 10.1016/j.scib.2026.09.048

Changhao Wang, Diancheng Chen, Zhefei Sun, Zhenhuang Su, Yizhen Huang, Dongyan Yu, Qizheng Zheng, Wei Li, Yawen Yan, Xiaoxiao Kuai, Juping Xu, Wen Yin, Maolin Yang, Yang Sun, Qiaobao Zhang, Yu Qiao, Haoshen Zhou, Shi-Gang Sun

{"title":"Enhancing interfacial stability of high-voltage LiCoO2 via fabricating a front-face with confined channels for desolvation.","authors":"Changhao Wang, Diancheng Chen, Zhefei Sun, Zhenhuang Su, Yizhen Huang, Dongyan Yu, Qizheng Zheng, Wei Li, Yawen Yan, Xiaoxiao Kuai, Juping Xu, Wen Yin, Maolin Yang, Yang Sun, Qiaobao Zhang, Yu Qiao, Haoshen Zhou, Shi-Gang Sun","doi":"10.1016/j.scib.2026.09.048","DOIUrl":"https://doi.org/10.1016/j.scib.2026.09.048","url":null,"abstract":"Lithium cobalt oxide (LiCoO2, LCO) is one of the most successful cathodes. However, it suffers from severe structural degradation and rapid capacity fading at high voltage (>4.5 V vs. Li+/Li). To improve high-voltage stability, researchers employ channel-type materials to desolvate lithium ions, resulting in a localized high-concentration environment. However, current channel-type materials, whether deployed as separators or additives, are hard to achieve effective desolvation of the electrolyte. Herein, we employ a facile and scalable high-speed solid-phase mechanofusion technique to construct a continuous and uniform zeolite coating layer on LCO (Zeolite@LCO). This inorganic zeolite layer physically decouples the Li+ desolvation process from the electric-field-driven intercalation. Enabled by the complete Li+ desolvation within the confined zeolite channels, a locally supersaturated electrolyte forms on the cathode surface, inherently suppressing the oxidative dehydrogenation of solvent molecules. Synergizing the confined channel effect with the intrinsic thermal robustness of the zeolite framework, this strategy comprehensively enhances the interfacial stability, thermal safety, and electrochemical performance of the Zeolite@LCO cathode. Consequently, Zeolite@LCO delivers an exceptional capacity retention of ∼83.0% after 300 cycles at a high cut-off voltage of 4.8 V. This confined channel interface design provides a highly translatable paradigm for developing high-energy-density cathodes innext-generation lithium-ion batteries.","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":20.7,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149102138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0