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National-scale genomic diagnosis of rare diseases in China. 中国罕见病的全国性基因组诊断。
IF 21.1 1区 综合性期刊
Science Bulletin Pub Date : 2025-08-25 DOI: 10.1016/j.scib.2025.08.044
Xiaodong Luan, Ye Jin, Liping Guan, Peng Liu, Hailong Feng, Dingding Zhang, Jingdan Chen, Weida Liu, Fangyuan Li, Anqi Wang, Kun Zhao, Ruirui He, Hankui Liu, Shida Zhu, Shuang Yang, Lijian Zhao, Jian Wang, Linkang Li, Dan Guo, Jianguo Zhang, Shuyang Zhang
{"title":"National-scale genomic diagnosis of rare diseases in China.","authors":"Xiaodong Luan, Ye Jin, Liping Guan, Peng Liu, Hailong Feng, Dingding Zhang, Jingdan Chen, Weida Liu, Fangyuan Li, Anqi Wang, Kun Zhao, Ruirui He, Hankui Liu, Shida Zhu, Shuang Yang, Lijian Zhao, Jian Wang, Linkang Li, Dan Guo, Jianguo Zhang, Shuyang Zhang","doi":"10.1016/j.scib.2025.08.044","DOIUrl":"https://doi.org/10.1016/j.scib.2025.08.044","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":21.1,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145038738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-purity (95 %) natural hydrogen accumulation uncovered in 1.6-billion-year-old strata. 在16亿年前的地层中发现了高纯度(95%)的天然氢气积累。
IF 21.1 1区 综合性期刊
Science Bulletin Pub Date : 2025-08-25 DOI: 10.1016/j.scib.2025.08.048
Xiaomei Wang, Kun He, Chunlong Yang, Yitong Lyu, Jiaxin Han, Linfeng Xie, Jinhao Guo, Shuichang Zhang, Zhijun Jin
{"title":"High-purity (95 %) natural hydrogen accumulation uncovered in 1.6-billion-year-old strata.","authors":"Xiaomei Wang, Kun He, Chunlong Yang, Yitong Lyu, Jiaxin Han, Linfeng Xie, Jinhao Guo, Shuichang Zhang, Zhijun Jin","doi":"10.1016/j.scib.2025.08.048","DOIUrl":"https://doi.org/10.1016/j.scib.2025.08.048","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":21.1,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145102635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coupled natural-social impacts on the sustainability of World Heritage sites. 自然-社会对世界遗产地可持续性的耦合影响。
IF 21.1 1区 综合性期刊
Science Bulletin Pub Date : 2025-08-23 DOI: 10.1016/j.scib.2025.08.040
Fulong Chen, Yunwei Tang, Huadong Guo, Hui Lin, Zhongchang Sun, Jianguo Liu
{"title":"Coupled natural-social impacts on the sustainability of World Heritage sites.","authors":"Fulong Chen, Yunwei Tang, Huadong Guo, Hui Lin, Zhongchang Sun, Jianguo Liu","doi":"10.1016/j.scib.2025.08.040","DOIUrl":"https://doi.org/10.1016/j.scib.2025.08.040","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":21.1,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145084802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Concentration-dependent visual SO2 detection from trace to pure in a zirconium MOF. 锆MOF中从痕量到纯二氧化硫的浓度依赖视觉检测。
IF 21.1 1区 综合性期刊
Science Bulletin Pub Date : 2025-08-23 DOI: 10.1016/j.scib.2025.08.041
Guang-Rui Si, Xiang-Jing Kong, Lin-Hua Xie, You-Tuo Zhang, Tao He, Jian-Rong Li
{"title":"Concentration-dependent visual SO<sub>2</sub> detection from trace to pure in a zirconium MOF.","authors":"Guang-Rui Si, Xiang-Jing Kong, Lin-Hua Xie, You-Tuo Zhang, Tao He, Jian-Rong Li","doi":"10.1016/j.scib.2025.08.041","DOIUrl":"https://doi.org/10.1016/j.scib.2025.08.041","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":21.1,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145028669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Migrion, a Migrasome-mediated unit for intercellular viral transmission. 迁移体:迁移体介导的细胞间病毒传播单位。
IF 21.1 1区 综合性期刊
Science Bulletin Pub Date : 2025-08-23 DOI: 10.1016/j.scib.2025.08.039
Yuxing Huang, Xiaojie Yan, Xing Liu, Congcong Ji, Wenmin Tian, Haohao Tang, Yong Li, Yiling Wen, Peiyao Fan, Hongli Wang, Cankun Xi, Zhongtian Li, Tian Lu, Fuping You, Xin Yin, Yang Chen
{"title":"Migrion, a Migrasome-mediated unit for intercellular viral transmission.","authors":"Yuxing Huang, Xiaojie Yan, Xing Liu, Congcong Ji, Wenmin Tian, Haohao Tang, Yong Li, Yiling Wen, Peiyao Fan, Hongli Wang, Cankun Xi, Zhongtian Li, Tian Lu, Fuping You, Xin Yin, Yang Chen","doi":"10.1016/j.scib.2025.08.039","DOIUrl":"https://doi.org/10.1016/j.scib.2025.08.039","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":21.1,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The lifespan trajectories of brain activities related to conflict-driven cognitive control. 与冲突驱动的认知控制相关的大脑活动的生命轨迹。
IF 21.1 1区 综合性期刊
Science Bulletin Pub Date : 2025-08-23 DOI: 10.1016/j.scib.2025.08.038
Zhenghan Li, Isaac T Petersen, Lingxiao Wang, Joaquim Radua, Guochun Yang, Xun Liu
{"title":"The lifespan trajectories of brain activities related to conflict-driven cognitive control.","authors":"Zhenghan Li, Isaac T Petersen, Lingxiao Wang, Joaquim Radua, Guochun Yang, Xun Liu","doi":"10.1016/j.scib.2025.08.038","DOIUrl":"10.1016/j.scib.2025.08.038","url":null,"abstract":"<p><p>Cognitive control is fundamental to human goal-directed behavior. Understanding its trajectory across the lifespan is crucial for optimizing cognitive function throughout life, particularly during periods of rapid development and decline. While existing studies have revealed an inverted U-shaped trajectory of cognitive control in both behavioral and anatomical domains, the age-related changes in functional brain activities remain poorly understood. To bridge this gap, we conducted a comprehensive meta-analysis of 139 neuroimaging studies using conflict tasks, encompassing 3765 participants aged 5 to 85 years. We adopted the seed-based d mapping (SDM), generalized additive model (GAM), and model comparison approaches to investigate age-related changes in brain activities to characterize the lifespan trajectories of cognitive control. Our analyses revealed two key findings: (1) The predominant lifespan trajectory is inverted U-shaped, rising from childhood to peak in young adulthood (between 27 and 36 years) before declining in later adulthood; (2) Both the youth and the elderly show weaker brain activities and greater left laterality than young adults. These results collectively reveal the lifespan trajectories of cognitive control, highlighting systematic fluctuations in brain activities with age.</p>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":21.1,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12435917/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145028778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electrode Net: tailoring deep learning with signed distance field for fast and accurate multiscale design of porous electrodes. 电极网:定制深度学习与签名距离场快速和准确的多尺度设计多孔电极。
IF 21.1 1区 综合性期刊
Science Bulletin Pub Date : 2025-08-21 DOI: 10.1016/j.scib.2025.08.026
Pengzhu Lin, Jing Sun, Yinglun Tang, Jiayou Ren, Xiaosa Xu, Jin Li, Changxiang He, Shuaibin Wan, Wenjia Li, Tianshou Zhao
{"title":"Electrode Net: tailoring deep learning with signed distance field for fast and accurate multiscale design of porous electrodes.","authors":"Pengzhu Lin, Jing Sun, Yinglun Tang, Jiayou Ren, Xiaosa Xu, Jin Li, Changxiang He, Shuaibin Wan, Wenjia Li, Tianshou Zhao","doi":"10.1016/j.scib.2025.08.026","DOIUrl":"https://doi.org/10.1016/j.scib.2025.08.026","url":null,"abstract":"<p><p>Designing novel porous electrodes with desirable merits is the key to advancing next-generation high-performing flow cells such as fuel cells, water electrolyzers, and flow batteries. However, engineering porous electrodes rationally and methodically remains challenging because it demands an in-depth understanding of their complex microstructures with extremely high computational costs. In this study, we develop a tailored deep learning framework (named \"Electrode Net\", a 3-dimensional convolutional neural network with signed distance field) to efficiently and accurately predict the anisotropic transport properties of porous electrodes. A comprehensive dataset consisting of 15,433 real and generated geometric samples and their corresponding anisotropic transport properties is constructed, using an experimentally and numerically validated pore-scale model. Electrode Net can significantly accelerate the design of porous electrodes by reducing the computational cost by up to 96% and with precise prediction (R-squared range: 0.95-0.99) of the porosity, tortuosity, and permeability. The outstanding generalizability of our model is further confirmed by accurate prediction of three practical flow cell electrodes in fuel cells, water electrolyzers, and flow batteries. Furthermore, we demonstrate a practical multiscale electrode design by incorporating the pore-scale anisotropic transport properties from Electrode Net into cell-scale simulations, enabling the rational and efficient optimization of three essential parameters of the gas diffusion layers in proton exchange membrane fuel cells.</p>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":21.1,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145102571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Navigating the lunar frontier: one hundred landing sites at the south pole for future mission challenges. 在月球前沿航行:在南极的100个着陆点为未来的任务挑战。
IF 21.1 1区 综合性期刊
Science Bulletin Pub Date : 2025-08-20 DOI: 10.1016/j.scib.2025.08.035
Yongjiu Feng, Pengshuo Li, Haoteng Li, Yan Liu, Mengrong Xi, Rong Wang, Shurui Chen, Panli Tang, Yuze Cao, Qian Huang, Qionghua You, Shijie Liu, Zhen Ye, Yusheng Xu, Xiong Xu, Chao Wang, Yanmin Jin, Sicong Liu, Huan Xie, Huaiyu He, Xiaohua Tong
{"title":"Navigating the lunar frontier: one hundred landing sites at the south pole for future mission challenges.","authors":"Yongjiu Feng, Pengshuo Li, Haoteng Li, Yan Liu, Mengrong Xi, Rong Wang, Shurui Chen, Panli Tang, Yuze Cao, Qian Huang, Qionghua You, Shijie Liu, Zhen Ye, Yusheng Xu, Xiong Xu, Chao Wang, Yanmin Jin, Sicong Liu, Huan Xie, Huaiyu He, Xiaohua Tong","doi":"10.1016/j.scib.2025.08.035","DOIUrl":"https://doi.org/10.1016/j.scib.2025.08.035","url":null,"abstract":"<p><p>Despite humanity's many lunar missions to the equatorial and mid-latitude regions, the south pole remains uncharted because of its exceptionally harsh conditions. The quest for water ice and the drive to establish lunar bases have positioned the south pole area above 80° latitude, characterized by permanently shaded regions and conducive to water ice preservation. However, the daunting terrain and intricate illumination in this area present significant challenges to engineering safety. Here, we introduce a Landing Feasibility Probability (LFP) model to evaluate the viability of potential landing sites. We pinpoint 120 prospective landing sites, stratified into 25 high-priority, 64 medium-priority, and 31 low-priority sites. These sites, encompassing a mere 0.6 % of the lunar south pole, have been rigorously vetted against 10 critical factors for landing feasibility. These sites show a pronounced clustering around 8 major craters and plateaus, organizing into 7 lunar site networks, with each network comprising 4 sites with a maximum dimension under 25 km, ideal for the development of lunar bases and observational networks. The LFP model's selection process is derived from a heuristic Genetic Algorithm (GA) informed by expert experience. The landing sites are strategically positioned to address the dual challenges of scientific goals and engineering safety at the lunar south pole, while also providing site selection guidance and facilitating international collaboration and communication for lunar expeditions. This method can also be adapted for site selection on other celestial bodies (e.g. Mars and asteroids) for scientific exploration and construction of extraterrestrial bases.</p>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":21.1,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Global platform ATES: interdisciplinary insights into past human-environment dynamics along the Silk Road. 全球平台ATES:丝绸之路沿线人类与环境动态的跨学科洞察。
IF 21.1 1区 综合性期刊
Science Bulletin Pub Date : 2025-08-20 DOI: 10.1016/j.scib.2025.08.030
Fahu Chen, Jürg Luterbacher, Michael E Meadows, Likun Ai, Juzhi Hou
{"title":"Global platform ATES: interdisciplinary insights into past human-environment dynamics along the Silk Road.","authors":"Fahu Chen, Jürg Luterbacher, Michael E Meadows, Likun Ai, Juzhi Hou","doi":"10.1016/j.scib.2025.08.030","DOIUrl":"https://doi.org/10.1016/j.scib.2025.08.030","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":21.1,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145028755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
wViP: an online server of word cloud visualization of biological profiles. wViP:生物档案文字云可视化在线服务器。
IF 21.1 1区 综合性期刊
Science Bulletin Pub Date : 2025-08-20 DOI: 10.1016/j.scib.2025.08.024
Jianzhen Peng, Miaomiao Chen, Xinhe Huang, Cheng Han, Di Peng, Yu Xue
{"title":"wViP: an online server of word cloud visualization of biological profiles.","authors":"Jianzhen Peng, Miaomiao Chen, Xinhe Huang, Cheng Han, Di Peng, Yu Xue","doi":"10.1016/j.scib.2025.08.024","DOIUrl":"https://doi.org/10.1016/j.scib.2025.08.024","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":21.1,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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