Science Bulletin最新文献_第10页

Design of heavy chain antibody-drug conjugates targeting c-Met to eradicate lung adenocarcinoma giant tumors with a single-dose 靶向c-Met的重链抗体-药物偶联物单剂量根除肺腺癌巨大肿瘤的设计。

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2025-05-09 DOI: 10.1016/j.scib.2025.04.066

Wenjing Ning , Han Liu , Hongye Zeng , Xiaojing Qin , Lin Xu , Shiting Yang , Zhiren Zeng , Na Yuan , Zhenzhen Zhu , Xiaoqing Chen , Tao Xu , Fentian Chen , Mengxuan Zhang , Jixian Tang , Yongkai Chen , Yuanzhi Chen , Xue Liu , Wenxin Luo , Ningshao Xia

引用次数: 0

Role of mitochondrial homeostasis in female reproductive system aging 线粒体稳态在女性生殖系统衰老中的作用。

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2025-05-09 DOI: 10.1016/j.scib.2025.04.067

Rusha Yin , Yaqian Li , Yiwei Zhang , Lan Zhu

引用次数: 0

Persistent Wnt signaling affects IVF embryo implantation and offspring metabolism 持续的Wnt信号影响IVF胚胎着床和子代代谢。

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2025-05-08 DOI: 10.1016/j.scib.2025.05.003

Yanping Jia , Yingdong Liu , Yanhe Li , Xiaohong Guan , Junting Xu , Zihui Yan , Kuisheng Liu , Yalin Zhang , Dandan Bai , Jiani Xiang , Yan Zhang , Shangyu Hou , Xiaochen Kou , Yanhong Zhao , Jiqing Yin , Hong Wang , Kunming Li , Shaorong Gao , Wenqiang Liu

{"title":"Persistent Wnt signaling affects IVF embryo implantation and offspring metabolism","authors":"Yanping Jia , Yingdong Liu , Yanhe Li , Xiaohong Guan , Junting Xu , Zihui Yan , Kuisheng Liu , Yalin Zhang , Dandan Bai , Jiani Xiang , Yan Zhang , Shangyu Hou , Xiaochen Kou , Yanhong Zhao , Jiqing Yin , Hong Wang , Kunming Li , Shaorong Gao , Wenqiang Liu","doi":"10.1016/j.scib.2025.05.003","DOIUrl":"10.1016/j.scib.2025.05.003","url":null,"abstract":"<div><div>Assisted reproductive technology (ART) is associated with increased implantation failure and subsequent metabolic abnormalities in offspring, but the underlying mechanisms remain largely elusive. Here, we reveal that persistent Wnt signaling during the peri-implantation stage may be a key obstacle to the implantation of <em>in vitro</em> fertilization (IVF) embryos in a mouse model. Wnt activation affects the deposition of H3K27ac and H3K27me3 on pluripotency genes and bivalent genes, respectively, leading to the abnormal naïve-primed transition and suppressing expression of <em>Otx2</em> in the epiblast. Furthermore, treatment with the Wnt inhibitor IWP2 promotes the redistribution of histone modifications and gene expression of epiblast. Importantly, Wnt inhibiting significantly improves implantation and intrauterine development of IVF embryos and subsequently ameliorates offspring metabolic abnormalities. Moreover, Wnt inhibiting markedly improves human peri-implantation embryo development and facilitates the transition from a naïve pluripotency state. Our study reveals a novel mechanism underlying the prevention of IVF embryo implantation failure and metabolic disorders in offspring.</div></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"70 14","pages":"Pages 2297-2311"},"PeriodicalIF":18.8,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Facilitating efficient catalytic conversion of polysulfides in lithium-sulfur batteries via self-assembled hydrogen-bond-rich covalent organic frameworks 通过自组装富氢键共价有机框架促进锂硫电池中多硫化物的高效催化转化。

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2025-05-08 DOI: 10.1016/j.scib.2025.05.005

Yang Shi , Shun Wang , Peiyu Cui , Jiacheng Ma , Xingxing Zhang , Zhuo Chen , Xuehan Hou , Xiao Li , Xilang Jin , Yanan Zhang , Yaoyu Wang , Wenhuan Huang

{"title":"Facilitating efficient catalytic conversion of polysulfides in lithium-sulfur batteries via self-assembled hydrogen-bond-rich covalent organic frameworks","authors":"Yang Shi , Shun Wang , Peiyu Cui , Jiacheng Ma , Xingxing Zhang , Zhuo Chen , Xuehan Hou , Xiao Li , Xilang Jin , Yanan Zhang , Yaoyu Wang , Wenhuan Huang","doi":"10.1016/j.scib.2025.05.005","DOIUrl":"10.1016/j.scib.2025.05.005","url":null,"abstract":"<div><div>The widespread commercialization of lithium-sulfur (Li-S) batteries is hindered by two critical challenges: sluggish redox kinetics and the detrimental polysulfide shuttle effect. In this study, we present a novel approach utilizing hydrogen-bond-rich covalent organic frameworks (TTP@PVDF50), synthesized through an <em>in situ</em> self-assembly process incorporating polymeric guest species. These covalent organic frameworks (COFs), when integrated into the separators of Li-S batteries, preserve their intrinsic porosity and crystallinity, while the abundant fluorine-rich sites and well-defined pore structures enhance lithium-ion (Li<sup>+</sup>) transport kinetics. The hydrogen-bond-rich nature of the COFs provides an effective strategy to mitigate the polysulfide shuttle, leveraging both spatial hindrance and strong polar interactions for enhanced adsorption. Density functional theory (DFT) calculations and <em>in situ</em> Raman spectroscopy reveal that the F∙∙∙OH hydrogen bonding network in the TTP@PVDF50 composite significantly accelerates Li<sup>+</sup> migration and catalyzes the conversion of LiPSs. The modified separator demonstrates a high discharge capacity of 1420.2 mAh g<sup>–1</sup> at 0.2 C (1 C=1675 mAh g<sup>–1</sup>), alongside remarkable anti-self-discharge performance with only 9.0% capacity loss. Notably, the Li-S battery with a high sulfur loading (4.59 mg cm<sup>–2</sup>) and a lean electrolyte (6 µL mg<sup>–1</sup>) retains over 83% of its capacity, underscoring the effectiveness of this strategy in advancing the performance and longevity of Li-S batteries.</div></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"70 13","pages":"Pages 2094-2103"},"PeriodicalIF":18.8,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular architecture and inhibition mechanism of human ATR-ATRIP 人ATR-ATRIP的分子结构及抑制机制。

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2025-05-06 DOI: 10.1016/j.scib.2025.05.009

Guangxian Wang , Po Wang , Zexuan Zheng , Qingjun Zhang , Chenchen Xu , Xinyi Xu , Lingfei Jian , Zhanpeng Zhao , Gang Cai , Xuejuan Wang

{"title":"Molecular architecture and inhibition mechanism of human ATR-ATRIP","authors":"Guangxian Wang , Po Wang , Zexuan Zheng , Qingjun Zhang , Chenchen Xu , Xinyi Xu , Lingfei Jian , Zhanpeng Zhao , Gang Cai , Xuejuan Wang","doi":"10.1016/j.scib.2025.05.009","DOIUrl":"10.1016/j.scib.2025.05.009","url":null,"abstract":"<div><div>The ataxia telangiectasia–mutated and Rad3-related (ATR) kinase is a master regulator of DNA damage response and replication stress in humans. Targeting ATR is the focus of oncology drug pipelines with a number of potent, selective ATR inhibitors currently in clinical development. Here, we determined the cryo-EM structures of the human ATR-ATRIP complex in the presence of VE-822 and RP-3500, two ATR inhibitors currently in Phase II clinical trials, achieving an overall resolution of approximately 3 Å. These structures yield a near-complete atomic model of the ATR-ATRIP complex, revealing subunit stoichiometry, intramolecular and intermolecular interactions, and critical regulatory sites including an insertion in the PIKK regulatory domain (PRD). Structural comparison provides insights into the modes of action and selectivity of ATR inhibitors. The divergent binding modes near the solvent side and in the rear pocket area of VE-822 and RP-3500, particularly their disparate binding orientations, lead to varying conformational changes in the active site. Surprisingly, one ATR-ATRIP complex binds four VE-822 molecules, with two in the ATR active site and two at the ATR-ATR dimer interface. The binding and selectivity of RP-3500 depend on two bound water molecules, which may be further enhanced by the substitution of these bound waters. Our study provides a structural framework for understanding ATR regulation and holds promise for assisting future efforts in rational drug design targeting ATR.</div></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"70 13","pages":"Pages 2137-2146"},"PeriodicalIF":18.8,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144085595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Controlled synthesis of metal-based Janus nanostructures for tandem electrocatalytic carbon dioxide reduction 串联电催化二氧化碳还原金属基Janus纳米结构的可控合成。

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2025-05-06 DOI: 10.1016/j.scib.2025.05.010

Yangbo Ma , Mingzheng Shao , Guozhi Wang , Liang Guo , Yunhao Wang , Fengkun Hao , Fu Liu , Xiang Meng , Chaohui Wang , Yuecheng Xiong , Zhanxi Fan

{"title":"Controlled synthesis of metal-based Janus nanostructures for tandem electrocatalytic carbon dioxide reduction","authors":"Yangbo Ma , Mingzheng Shao , Guozhi Wang , Liang Guo , Yunhao Wang , Fengkun Hao , Fu Liu , Xiang Meng , Chaohui Wang , Yuecheng Xiong , Zhanxi Fan","doi":"10.1016/j.scib.2025.05.010","DOIUrl":"10.1016/j.scib.2025.05.010","url":null,"abstract":"<div><div>Electrochemical carbon dioxide reduction reaction (CO<sub>2</sub>RR) possesses huge potential for achieving carbon neutrality by reducing greenhouse-gas CO<sub>2</sub> to value-added chemicals/fuels with sustainable energy. However, obtaining highly selective and long-term stable catalysts for CO<sub>2</sub>RR is still challenging. Recently, metal-based Janus nanostructures (JNSs) have demonstrated unique advantages in addressing this issue in CO<sub>2</sub>RR via tandem catalysis. Herein, we systematically summarize the recently developed metal-based JNSs for electrocatalytic CO<sub>2</sub>RR. The synthesis methods are first introduced, including three representative methods (seed-mediated growth, dimerization, and selective-etching) and the strategy for constructing specific facets or unconventional phases in metal-based JNSs. Then, the application of metal-based JNSs in CO<sub>2</sub>RR toward the generation of single-carbon and multi-carbon products is elaborated, along with the corresponding catalytic mechanisms. The structural reconstruction of metal-based JNSs is also discussed in detail. Finally, we briefly summarize the recent advances and provide personal perspectives in this research direction.</div></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"70 14","pages":"Pages 2330-2346"},"PeriodicalIF":18.8,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144140989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

β-hydroxybutyrate enhances mitochondrial function via mitochondrial-derived vesicles. β-羟基丁酸通过线粒体来源的囊泡增强线粒体功能。

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2025-05-06 DOI: 10.1016/j.scib.2025.05.011

Feixiang Bao, Dingxin Zeng, Jiahui Xiao, Lingyan Zhou, Xingguo Liu

引用次数: 0

A heterogeneous lunar mantle revealed by young low-Ti mare basalt NWA 16460. 年轻低钛海玄武岩NWA 16460揭示的非均质月幔。

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2025-05-06 DOI: 10.1016/j.scib.2025.05.008

Weibiao Hsu, Aoxin Mei, Yukang Liang, Lei Jin, Kai Zhao, Lihui Chen, Shaolin Li, Chipui Tang

引用次数: 0

Dual-solvent-induced persistent nanoscale wet film for controllable two-dimensional molecular crystallization toward polarization-sensitive photodetectors. 用于可控二维分子结晶的双溶剂诱导持久纳米级湿膜。

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2025-05-05 DOI: 10.1016/j.scib.2025.05.007

Yumeng Wang, Lujing Shao, Yu Chen, Shengnan Chen, Yongrui Yang, Fanyi Min, Mengmeng Guo, Wenkun Lv, Zheng Li, Zhiyuan Qu, Lutong Guo, Jie Gao, Xiaodong Yin, Yali Yu, Zhongming Wei, Yanlin Song, Yali Qiao

{"title":"Dual-solvent-induced persistent nanoscale wet film for controllable two-dimensional molecular crystallization toward polarization-sensitive photodetectors.","authors":"Yumeng Wang, Lujing Shao, Yu Chen, Shengnan Chen, Yongrui Yang, Fanyi Min, Mengmeng Guo, Wenkun Lv, Zheng Li, Zhiyuan Qu, Lutong Guo, Jie Gao, Xiaodong Yin, Yali Yu, Zhongming Wei, Yanlin Song, Yali Qiao","doi":"10.1016/j.scib.2025.05.007","DOIUrl":"https://doi.org/10.1016/j.scib.2025.05.007","url":null,"abstract":"<p><p>Two-dimensional organic semiconductor single crystals (2D OSSCs) have great potential for use in high-performance optoelectronic devices. However, challenges associated with controlling complex fluid dynamics and molecular mass transfer during solution-based processes hinder large-scale high-quality production. To address this issue, we developed a nanoconfinement-driven approach for controlling molecular crystallization, improving isotropic molecular mass transfer in fluids, and regulating the morphology of the 2D molecular film. Using a dual-solvent strategy, we created a stable nanoscale extended evaporation meniscus that modulates molecular nucleation and growth dynamics, thereby facilitating the direct shift from one-dimensional to two-dimensional crystals. Dual solvents are essential for generating and maintaining nanoscale wet films during meniscal recession, which is crucial for 2D crystal engineering. Mechanistic studies revealed that adhesion in a dual-solvent system is vital for meniscus formation while disjoining pressure maintains its stability. We also systematically evaluated several [1]benzothieno[3,2-b][1]benzothiophenes (BTBTs) bearing various alkyl chains, which revealed how molecular interactions affect morphology during printing. Organic-field-effect transistors fabricated using 2D OSSCs have significantly higher carrier mobilities than those with striped structures. Moreover, the highly ordered 2D C8-BTBT single-crystal thin film exhibited high sensitivity to polarized ultraviolet light, boasting a dichroic ratio of 2.80 and demonstrating exceptional imaging capabilities for polarized ultraviolet light.</p>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144140992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nitrate wastewater regeneration in coastal arid region 沿海干旱区硝酸盐废水再生研究。

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2025-05-05 DOI: 10.1016/j.scib.2025.05.004

Xia Zhang , Solmaz Feizpoor , Muhammad Humayun , Xianbiao Fu , Chundong Wang

引用次数: 0