Science Bulletin最新文献

{"title":"Crosstalk of immunity and neuroscience in the tumor microenvironment.","authors":"Zewen Zhang, Yingying Shao, Yu Wang, Chunze Zhang, Tao Wang, Haiyang Yu","doi":"10.1016/j.scib.2025.04.022","DOIUrl":"https://doi.org/10.1016/j.scib.2025.04.022","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrinsic microcavity in OLET: a promising approach for integrated narrowed electroluminescence devices.","authors":"Chuluo Yang","doi":"10.1016/j.scib.2025.04.020","DOIUrl":"https://doi.org/10.1016/j.scib.2025.04.020","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"STING-activating pyroptotic nanoparticles for in situ pancreatic cancer vaccination and immunotherapy.","authors":"Shiyi Shao, Xiaohong Chen, Yuxuan Chen, Meng Wang, Junmin Huang, Jianwei Wang, Xiazhen Yu, Xinya Li, Yao Zhang, Yuan Ping, Qida Hu, Tingbo Liang","doi":"10.1016/j.scib.2025.04.015","DOIUrl":"https://doi.org/10.1016/j.scib.2025.04.015","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Land ecology for achieving China's ecological civilization: key issues and frontier topics.","authors":"Jian Peng, Tao Hu, Dongmei Xu, Zihan Xu, Huining Zheng, Yifan Lin, Yupeng Wang, Jianquan Dong, Yanxu Liu","doi":"10.1016/j.scib.2025.04.021","DOIUrl":"https://doi.org/10.1016/j.scib.2025.04.021","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-situ atmospheric thermoelectric conversion on Mars.","authors":"Yuzhuo Yang, Yonghao Zhang, Yu Yao, Gang Pei, Hua Tian, Lingfeng Shi, Gequn Shu","doi":"10.1016/j.scib.2025.04.013","DOIUrl":"https://doi.org/10.1016/j.scib.2025.04.013","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary arterial hypertension: a long-standing and nonnegligible burden over three decades.","authors":"Jia-Yong Qiu, Lu-Hong Qiu, Shen-Shen Huang, Bao-Chen Qiu, Chao Liu, Dong Ding, Yue-Jiao Ma, Yu-Ping Zhou, Chun-Yan Cheng, Meng-Yi Liu, Xiao-Wei Gong, Tong-Sheng Wang, Yi-Min Mao, Ya-Dong Yuan, Hai-Long Dai, Zhi-Cheng Jing","doi":"10.1016/j.scib.2025.04.014","DOIUrl":"https://doi.org/10.1016/j.scib.2025.04.014","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-omic analyses of the development of obesity-related depression linked to the gut microbe Anaerotruncus colihominis and its metabolite glutamate.","authors":"Zhengyan Chang, Yefei Zhu, Ping Wang, Lei Du, Minkang Wu, Xingchun Wang, Cheng Kong, Dengfeng Huang, Ruting Xie, Guo Ji, Chao Wang, Liang Cheng, Xuebing Yan, Qing Wei, Huanlong Qin","doi":"10.1016/j.scib.2025.04.010","DOIUrl":"https://doi.org/10.1016/j.scib.2025.04.010","url":null,"abstract":"<p><p>Emerging evidence implicates gut microbiota in the pathogenesis of obesity-related depression (OD); however, the underlying molecular mechanisms remain inadequately explored. This study compared the microbial and transcriptional profiles between patients with OD and healthy individuals. The results revealed an enrichment of Anaerotruncus colihominis (A. colihominis) and glutamate metabolism-related genes in the OD group. Fecal microbiota transplantation (FMT) from patients with OD induced weight gain, compromised barrier function, and intensified depression-like behaviors in high-fat diet (HFD) mice. Microbial analysis in the mice feces corroborated the clinical findings. Single-cell RNA sequencing highlighted the pivotal role of the Efnb2-Ephb2 interaction in cell communication among colon epithelial and hippocampal neuron subtypes in OD mice. Notably, A. colihominis correlated with glutamate levels in the OD mice and patients. It produced glutamate through a glutamic acid metabolism-related DNA sequence, verified in an engineered Escherichia coli MG1655 strain. Both A. colihominis and glutamate reduced barrier proteins in colon epithelial cells and modulated cognitive proteins in neurons. Finally, A. colihominis treatment induced the Efnb2-Ephb2 interaction, exacerbating depression-like behaviors in germ-free HFD mice. Collectively, these findings reveal that A. colihominis and glutamate are potential intervention targets for OD treatment.</p>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143951716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orbital hybridizations in single-atom catalysts for electrocatalysis.","authors":"Luoluo Qi, Jingqi Guan","doi":"10.1016/j.scib.2025.04.009","DOIUrl":"https://doi.org/10.1016/j.scib.2025.04.009","url":null,"abstract":"<p><p>Single-atom catalysts (SACs) are rapidly standing at the forefront of catalytic development due to their unique structures with significantly different catalytic activity, selectivity, and stability from conventional nanocatalysts. The electronic properties and catalytic performances of SACs hinge on the results of orbital hybridization of isolated central atoms with ligand atoms as well as of central atoms with bonding atoms provided by intermediates. Therefore, we conduct multifaceted explorations around orbital hybridizations in single-atom catalysis to elucidate the structure-activity relationships. Firstly, we introduce the basic theoretical knowledge related to orbital hybridizations, and summarize the main descriptors of orbital hybridizations, focusing on the discussion of the types of orbital hybridizations in single-atom catalysis. Then, we briefly sum up the application of orbital hybridizations in single-atom electrocatalysis and put forward important strategies for regulating orbital hybridizations in SACs to improve the catalytic performances. Finally, we present a personal perspective on the future challenges and opportunities of orbital hybridizations in single-atom catalysis.</p>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resolving the Snowball Earth conundrum: the role of marine dissolved organic carbon pool.","authors":"Bing Shen, Xianguo Lang, Ruimin Wang, Yonggang Liu, Shihong Zhang, Tianzheng Huang, Xuelei Chu, Yixin Cui, Weiming Ding, Yuansheng Du, Ran He, Kangjun Huang, Yongyun Hu, Jun Hu, Shangyi Gu, Hongwei Kuang, Zhongwu Lan, Chao Li, Fangbing Li, Yongqing Liu, Genming Luo, Haoran Ma, Meng Ning, Yuangao Qu, Yang Peng, Yongbo Peng, Jian Wang, Jiasheng Wang, Chaochao Xing, Bei Xu, Jun Yang, Qin Ye, Zongjun Yin, Wenchao Yu, Xunlai Yuan, Chuanming Zhou, Shengxian Zhu, Xiangkun Zhu","doi":"10.1016/j.scib.2025.03.056","DOIUrl":"https://doi.org/10.1016/j.scib.2025.03.056","url":null,"abstract":"<p><p>The Cryogenian Sturtian (717-660 Ma) and Marinoan glacial deposits (∼650-635 Ma), typically consisting of alternating layers of glaciogenic diamictite and clast-free lithofacies, indicate dynamic glaciers or glacial-interglacial cycles during the global glaciations. This may result from ice sublimation in tropics under a Snowball Earth condition. However, this model fails to explain the deposition patterns observed in mid-latitude continents. We propose the presence of unfrozen oceans while the continents are covered, i.e., the icy-continents. The open-ocean condition requires low atmospheric pCO₂ level. We argued that the mantle CO₂ degassing could be counterbalanced by a growing pool of dissolved organic carbon (DOC) in the deep ocean, maintaining a small marine dissolved inorganic carbon (DIC) pool and a low atmospheric pCO₂ level. The persistent marine productivity in the open ocean would support the expanded DOC pool due to reduced ocean ventilation and limited terrestrial inputs of oxidants. However, the global glaciation with open oceans was climatically unstable. The fluctuation of the DOC pool on a local or regional scale likely contributed to the frequent glacial-interglacial oscillations recorded in the rock records. Additionally, the expansion of the DOC pool removed seawater nutrients, e.g., phosphorus (P), and insufficient nutrient supply prevented the transfer of mantle-degassing carbon as DOC, ultimately leading to the termination of global glaciation. The turnover of the DOC pool, caused by deep ocean ventilation in the deglacial period, significantly increased the atmospheric pCO₂ level. This event was followed by intense continental weathering, increased seawater pH, recovery of primary productivity, cap carbonate precipitation, and eventually, the emergence of new life forms and innovations in the biosphere.</p>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large hydrogen hydrothermal pipe swarm identified in the deep ocean.","authors":"Lianfu Li, Hongyun Zhang, Shichuan Xi, Chenglong Liu, Congying Li, Jian Zheng, Jing Huang, Yufei Hao, Xin Zhang, Weidong Sun","doi":"10.1016/j.scib.2025.04.006","DOIUrl":"https://doi.org/10.1016/j.scib.2025.04.006","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}