Science Bulletin最新文献

{"title":"Thioketal-photocage: a universal modification strategy for constructing new photochemical tools for real-time imaging in living cells","authors":"Ding-Heng Zhou ,&nbsp;Shan-Yong Chen ,&nbsp;Yan-Zhao Liu ,&nbsp;Hong Zhang ,&nbsp;Jun-Mei Li ,&nbsp;Qian Zhou ,&nbsp;Fei-Fan Xiang ,&nbsp;Xiao-Qi Yu ,&nbsp;Kun Li","doi":"10.1016/j.scib.2025.01.037","DOIUrl":"10.1016/j.scib.2025.01.037","url":null,"abstract":"<div><div>Photoactivable fluorescent probes (photocages) are powerful tools for studying biological processes in living cells. We report a novel class of photodegradable thioketals that serve as photo-responsive elements and apply them to xanthene dyes to design photocages for live cell imaging. Compared with traditional thioketals, these compounds demonstrate the ability to undergo deprotection upon exposure to ultraviolet–visible light, independent of photosensitizers or external oxidants and relying solely on dissolved oxygen within the solvent. This photoreaction results in a remarkable 68-fold increase in fluorescence intensity. We verify that the uncaged product is the corresponding ketone, with high-performance liquid chromatography analysis, which indicates a yield of up to 80%. Furthermore, we extend this modification strategy to xanthene dyes substituted with various heteroatoms and confirm the universal applicability of this photoactivable strategy. These dyes exhibit good stability against reducing agents and metal ions, with carbon and silicon xanthene photocages also demonstrating commendable dark stability against reactive oxygen species. We apply these photocages for bioimaging and further modify them for selective labeling, activation, and imaging of specific organelles and intracellular proteins within living cells. This modification strategy offers high spatiotemporal selectivity and holds promise as a powerful tool for advanced biological studies.</div></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"70 7","pages":"Pages 1087-1096"},"PeriodicalIF":18.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visualizing the dynamic evolution of light-sensitive Cu1+/Cu2+ sites during photocatalytic CO2 reduction with an advanced in situ EPR spectroscopy","authors":"Qin Ren ,&nbsp;Ye He ,&nbsp;Yanjuan Sun ,&nbsp;Shihan Zhang ,&nbsp;Fan Dong","doi":"10.1016/j.scib.2025.01.047","DOIUrl":"10.1016/j.scib.2025.01.047","url":null,"abstract":"<div><div>Elucidation of the dynamic evolution of active sites is still a challenge in investigating the catalytic mechanism mainly due to the difficulty in accurately detecting the transient structural changes of active sites under operating conditions. Here, we develop an advanced <em>in situ</em> electron paramagnetic resonance (EPR) spectroscopy, which could sensitively monitor and visualize the dynamic evolution of paramagnetic active sites during photoreduction CO₂. <em>In situ</em> results reveal that the photoactivated Cu¹⁺ sites from CuO nanoclusters/TiO₂ serve as the authentic active sites in the reaction and exhibit self-regenerative capability. The CO₂ molecules can acquire electrons and get activated by the photoactivated Cu¹⁺, leading to the transition of Cu¹⁺ sites into Cu²⁺ sites. Subsequently, the Cu²⁺ sites expedite the generation of hydrogen protons through antiferromagnetic coupling with hydroxyl radicals, thereby promoting the production of the final product CH₄ via a multi proton-coupled electron transfer (PCET) process. This work reveals and visualizes the dynamic evolution of Cu-based active sites during photocatalytic reactions by combined <em>in situ</em> characterizations, providing new perspectives on the mechanistic understanding of paramagnetic active sites under operation.</div></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"70 7","pages":"Pages 1097-1106"},"PeriodicalIF":18.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental realization of valley vortex states in water wave crystals","authors":"Zijian Qin ,&nbsp;Qiaolu Chen ,&nbsp;Lian Shen ,&nbsp;Yihao Yang ,&nbsp;Hongsheng Chen ,&nbsp;Huaping Wang","doi":"10.1016/j.scib.2025.01.009","DOIUrl":"10.1016/j.scib.2025.01.009","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"70 7","pages":"Pages 1034-1037"},"PeriodicalIF":18.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143035841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-shot miniaturized spectrometer without lithography","authors":"Lijun Song ,&nbsp;Zhimin Zhu ,&nbsp;Yixuan Wang ,&nbsp;Dunzhao Wei,&nbsp;Jin Liu","doi":"10.1016/j.scib.2025.04.032","DOIUrl":"10.1016/j.scib.2025.04.032","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"70 12","pages":"Pages 1918-1921"},"PeriodicalIF":18.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pole trajectories of the Λ(1405) help establish its dynamical nature","authors":"Zejian Zhuang ,&nbsp;Raquel Molina ,&nbsp;Jun-Xu Lu ,&nbsp;Li-Sheng Geng","doi":"10.1016/j.scib.2025.04.029","DOIUrl":"10.1016/j.scib.2025.04.029","url":null,"abstract":"<div><div>The <span><math><mrow><mi>Λ</mi><mo>(</mo><mn>1405</mn><mo>)</mo></mrow></math></span> has been one of the most controversial exotic baryons. If the <span><math><mrow><mi>Λ</mi><mo>(</mo><mn>1405</mn><mo>)</mo></mrow></math></span> possesses a two-pole molecular structure, these poles are expected to evolve differently towards the SU(3) limit. From an analysis of a recent LQCD simulation on the <span><math><mrow><mi>π</mi><mi>Σ</mi><mo>-</mo><mover><mrow><mi>K</mi></mrow><mrow><mo>‾</mo></mrow></mover><mi>N</mi></mrow></math></span> scattering for <span><math><mrow><mi>I</mi><mo>=</mo><mn>0</mn></mrow></math></span> and the study of the quark mass dependence of the octet baryon masses, we determine for the first time the trajectories of these poles towards the symmetric point over the <span><math><mrow><mi>Tr</mi><mo>[</mo><mi>M</mi><mo>]</mo><mo>=</mo><mi>C</mi></mrow></math></span> trajectory accurately. At <span><math><mrow><msub><mrow><mi>m</mi></mrow><mrow><mi>π</mi></mrow></msub><mo>≃</mo><mn>200</mn></mrow></math></span> MeV, our results are consistent with the lattice simulations, and the extrapolations to the physical point, based on the NLO chiral Lagrangians, agree well with existing experimental analyses. We predict qualitatively similar trajectories at LO and up to NLO, consistent with the LO interaction’s dominance. At the SU(3) symmetric point of this trajectory, both poles are on the physical sheet, and the lower pole is located at <span><math><mrow><msup><mrow><mi>E</mi></mrow><mrow><mo>(</mo><mn>1</mn><mo>)</mo></mrow></msup><mo>=</mo><mn>1573</mn><mo>(</mo><mn>6</mn><mo>)</mo><mo>(</mo><mn>6</mn><mo>)</mo></mrow></math></span> MeV, becoming a SU(3) singlet, while the higher pole at <span><math><mrow><msup><mrow><mi>E</mi></mrow><mrow><mo>(</mo><mn>8</mn><mi>a</mi><mo>)</mo></mrow></msup><mo>=</mo><mn>1589</mn><mo>(</mo><mn>7</mn><mo>)</mo><mo>(</mo><mn>5</mn><mo>)</mo></mrow></math></span> MeV couples to the octet representation. Moreover, we make predictions in <span><math><mrow><mi>I</mi><mo>=</mo><mn>1</mn></mrow></math></span> for the <span><math><mrow><msup><mrow><mi>Σ</mi></mrow><mrow><mo>∗</mo></mrow></msup></mrow></math></span> resonance. We find a resonance pole that evolves into a bound state around <span><math><mrow><msub><mrow><mi>m</mi></mrow><mrow><mi>π</mi></mrow></msub><mo>=</mo><mn>415</mn></mrow></math></span> MeV in this sector. The results presented here are crucial to shed light on the molecular nature of exotic strange baryon resonances and can be tested in future LQCD simulations</div></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"70 12","pages":"Pages 1953-1961"},"PeriodicalIF":18.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Full realization of the RIBLL2 separator at the HIRFL-CSR facility","authors":"Xiao-Dong Xu ,&nbsp;Yong Zheng ,&nbsp;Zhi-Yu Sun ,&nbsp;Yu-Nan Song ,&nbsp;Bao-Hua Sun ,&nbsp;Satoru Terashima ,&nbsp;Chang-Jian Wang ,&nbsp;Ge Guo ,&nbsp;Guang-Shuai Li ,&nbsp;Xiu-Lin Wei ,&nbsp;Jun-Yao Xu ,&nbsp;Ji-Chao Zhang ,&nbsp;Yong Cao ,&nbsp;Bing-Shui Gao ,&nbsp;Jia-Xing Han ,&nbsp;Jin-Rong Liu ,&nbsp;Chen-Gui Lu ,&nbsp;Shu-Ya Jin ,&nbsp;Hooi Jin Ong ,&nbsp;Hao-Tian Qi ,&nbsp;Li-Hua Zhu","doi":"10.1016/j.scib.2025.01.020","DOIUrl":"10.1016/j.scib.2025.01.020","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"70 7","pages":"Pages 1026-1029"},"PeriodicalIF":18.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Needle-free injection devices for targeted oral delivery of macromolecules","authors":"Zhonglin Fang,&nbsp;Zhuohao Zhang,&nbsp;Luoran Shang","doi":"10.1016/j.scib.2025.02.003","DOIUrl":"10.1016/j.scib.2025.02.003","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"70 7","pages":"Pages 1010-1012"},"PeriodicalIF":18.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revolutionizing cerebral monitoring: the innovative leap of ultrasound patch technology and its future horizons","authors":"Yihan Li ,&nbsp;Ding Zhao ,&nbsp;Lei Xiang,&nbsp;Qinzhe Jiang,&nbsp;Wenguo Cui","doi":"10.1016/j.scib.2025.02.002","DOIUrl":"10.1016/j.scib.2025.02.002","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"70 7","pages":"Pages 1007-1009"},"PeriodicalIF":18.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioengineering strategies for augmenting wound-healing efficacy of mesenchymal stem cell-derived extracellular vesicles","authors":"Xianhao Shi ,&nbsp;Nan Fu ,&nbsp;Huan Zhang ,&nbsp;Holly M. Brown-Borg ,&nbsp;Shihua Wang ,&nbsp;Robert Chunhua Zhao","doi":"10.1016/j.scib.2024.10.024","DOIUrl":"10.1016/j.scib.2024.10.024","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"70 7","pages":"Pages 987-990"},"PeriodicalIF":18.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tripling of MJO residence time over the rapidly warming Indian Ocean during summer monsoon","authors":"Wenjun Zhang ,&nbsp;Xuben Lei ,&nbsp;Guosen Chen ,&nbsp;Pang-Chi Hsu ,&nbsp;Feng Jiang ,&nbsp;Malte Stuecker ,&nbsp;Fei-Fei Jin ,&nbsp;Chao Liu","doi":"10.1016/j.scib.2025.01.043","DOIUrl":"10.1016/j.scib.2025.01.043","url":null,"abstract":"<div><div>The Madden-Julian Oscillation (MJO) is the dominant mode of intraseasonal tropical atmospheric variability with far-reaching influences on global weather systems. During boreal winter, the MJO typically exhibits regular eastward propagation, whereas in summer, it displays more complex propagation characteristics, such as frequent stalling over the Indian Ocean. Here we show a threefold increase in the MJO residence time over the Indian Ocean during the Asian summer monsoon in recent four decades. This drastic increase is closely associated with the rapid warming of the Indian Ocean, which contributes to increased extreme climate events across Indian Ocean rim countries. This peculiar warming pattern is projected to persist under anthropogenic warming, potentially facilitating prolonged MJO activity over the Indian Ocean with higher climatic disaster risks in the future.</div></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"70 7","pages":"Pages 1174-1181"},"PeriodicalIF":18.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}