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New insights into the population history of East Asia from ancient genomes from Yunnan. 云南古代基因组对东亚种群历史的新认识。
IF 18.8 1区 综合性期刊
Science Bulletin Pub Date : 2025-07-01 DOI: 10.1016/j.scib.2025.06.037
Mark Stoneking
{"title":"New insights into the population history of East Asia from ancient genomes from Yunnan.","authors":"Mark Stoneking","doi":"10.1016/j.scib.2025.06.037","DOIUrl":"https://doi.org/10.1016/j.scib.2025.06.037","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AP2-domain transcription factor WRI5a-regulated MtABCB1 promotes arbuscule development in mycorrhizal symbiosis. ap2结构域转录因子wr5a调控的MtABCB1促进菌根共生中的丛枝发育。
IF 18.8 1区 综合性期刊
Science Bulletin Pub Date : 2025-06-28 DOI: 10.1016/j.scib.2025.06.033
Wanxiao Wang, Yuting Wang, Qiujin Xie, Jincai Shi, Linfeng Sun, Zuhua He, Jeremy Murray, Ertao Wang, Nan Yu, Xiaowei Zhang
{"title":"AP2-domain transcription factor WRI5a-regulated MtABCB1 promotes arbuscule development in mycorrhizal symbiosis.","authors":"Wanxiao Wang, Yuting Wang, Qiujin Xie, Jincai Shi, Linfeng Sun, Zuhua He, Jeremy Murray, Ertao Wang, Nan Yu, Xiaowei Zhang","doi":"10.1016/j.scib.2025.06.033","DOIUrl":"https://doi.org/10.1016/j.scib.2025.06.033","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence and related factors of antenatal depression in 11 provinces and cities of China: a 100,000 population-based study. 中国11个省市产前抑郁患病率及相关因素：一项基于10万人的研究
IF 18.8 1区 综合性期刊
Science Bulletin Pub Date : 2025-06-28 DOI: 10.1016/j.scib.2025.06.031
Chen Zhang, Chenchi Duan, Han Liu, Hualin Xu, Cheng Li, Jianxia Fan, Hong Li, Xiangjuan Li, Yi Guo, Yeping Wang, Xiufeng Li, Jing Li, Ting Zhang, Yiping You, Hongmei Li, Shuangqi Yang, Xiaoling Tao, Yajuan Xu, Haihong Lao, Ming Wen, Yan Zhou, Junying Wang, Yuhua Chen, Diyun Meng, Jingli Zhai, Youchun Ye, Qinwen Zhong, Xiuping Yang, Jing Zhang, Xifeng Wu, Wei Chen, Cindy-Lee Dennis, Ben Willem J Mol, Dan Zhang, Hefeng Huang, Yanting Wu
{"title":"Prevalence and related factors of antenatal depression in 11 provinces and cities of China: a 100,000 population-based study.","authors":"Chen Zhang, Chenchi Duan, Han Liu, Hualin Xu, Cheng Li, Jianxia Fan, Hong Li, Xiangjuan Li, Yi Guo, Yeping Wang, Xiufeng Li, Jing Li, Ting Zhang, Yiping You, Hongmei Li, Shuangqi Yang, Xiaoling Tao, Yajuan Xu, Haihong Lao, Ming Wen, Yan Zhou, Junying Wang, Yuhua Chen, Diyun Meng, Jingli Zhai, Youchun Ye, Qinwen Zhong, Xiuping Yang, Jing Zhang, Xifeng Wu, Wei Chen, Cindy-Lee Dennis, Ben Willem J Mol, Dan Zhang, Hefeng Huang, Yanting Wu","doi":"10.1016/j.scib.2025.06.031","DOIUrl":"https://doi.org/10.1016/j.scib.2025.06.031","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular windows for ischemic stroke treatment. 缺血性脑卒中治疗的分子窗。
IF 18.8 1区 综合性期刊
Science Bulletin Pub Date : 2025-06-28 DOI: 10.1016/j.scib.2025.06.032
Qi Liu, Chuanjie Wu, Marc Fisher, Di Wu, Xunming Ji
{"title":"Molecular windows for ischemic stroke treatment.","authors":"Qi Liu, Chuanjie Wu, Marc Fisher, Di Wu, Xunming Ji","doi":"10.1016/j.scib.2025.06.032","DOIUrl":"https://doi.org/10.1016/j.scib.2025.06.032","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Conformational control of Ni coordination sites in pyridyl-functionalized covalent organic frameworks for exceptional CO2 photoreduction. 吡啶官能化共价有机骨架中镍配位位的构象控制。
IF 18.8 1区 综合性期刊
Science Bulletin Pub Date : 2025-06-25 DOI: 10.1016/j.scib.2025.06.025
Xinyi Zeng, Meiyan Guo, Lei Wang, Hetao Xu, Chao Lin, Zhipeng Luo, Fengtao Zhang, Shipeng Zhu, Sibo Wang, Yuanxing Fang, Wei Lin, Xiong Chen
{"title":"Conformational control of Ni coordination sites in pyridyl-functionalized covalent organic frameworks for exceptional CO<sub>2</sub> photoreduction.","authors":"Xinyi Zeng, Meiyan Guo, Lei Wang, Hetao Xu, Chao Lin, Zhipeng Luo, Fengtao Zhang, Shipeng Zhu, Sibo Wang, Yuanxing Fang, Wei Lin, Xiong Chen","doi":"10.1016/j.scib.2025.06.025","DOIUrl":"https://doi.org/10.1016/j.scib.2025.06.025","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Liquid biopsy-based multi-cancer early detection: an exploration road from evidence to implementation. 基于液体活检的多癌早期检测：一条从证据到实施的探索之路。
IF 18.8 1区 综合性期刊
Science Bulletin Pub Date : 2025-06-24 DOI: 10.1016/j.scib.2025.06.030
Yongjie Xu, Sibo Zhu, Changfa Xia, Hui Yu, Si Shi, Kezhong Chen, Yue He, Chuxia Deng, Haoxuan Jin, Jing Liu, Rebecca Fitzgerald, Partha Basu, Wanqing Chen
{"title":"Liquid biopsy-based multi-cancer early detection: an exploration road from evidence to implementation.","authors":"Yongjie Xu, Sibo Zhu, Changfa Xia, Hui Yu, Si Shi, Kezhong Chen, Yue He, Chuxia Deng, Haoxuan Jin, Jing Liu, Rebecca Fitzgerald, Partha Basu, Wanqing Chen","doi":"10.1016/j.scib.2025.06.030","DOIUrl":"https://doi.org/10.1016/j.scib.2025.06.030","url":null,"abstract":"<p><p>Current cancer screening methods are limited in scope, often detecting only a few cancer types with low positive predictive value and suboptimal patient adherence. In recent years, liquid biopsy-based multi-cancer early detection (MCED) has emerged as a promising approach to revolutionize cancer control. Despite several MCED tests reaching clinical trial phases and seeking regulatory approval, none have yet been approved for clinical use, highlighting uncertainties regarding their efficacy and applicability. This review comprehensively examines the advancements in MCED technologies and offers insights into the selection of cancer types for inclusion in MCED panels. We explore the clinical development pathway for MCED, from biomarker discovery and analytical validation to large-scale randomized controlled trials, emphasizing the importance of selecting appropriate endpoints such as reducing late-stage cancer incidence or cancer-specific mortality. Key challenges, including achieving optimal sensitivity for early-stage cancers, minimizing false positives and negatives, and ensuring equitable access to MCED tests, are also addressed. Finally, we evaluate the added value and health economic benefits of integrating MCED into established healthcare systems through widespread implementation. By providing a thorough analysis of these aspects, this review aims to advance the field of cancer screening and guide future research and development efforts.</p>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Terrestrial ecosystems enhanced root zone water storage capacity in response to climate change over the past four decades. 在过去40年里，陆地生态系统增强了根区蓄水能力，以应对气候变化。
IF 18.8 1区 综合性期刊
Science Bulletin Pub Date : 2025-06-21 DOI: 10.1016/j.scib.2025.06.027
Qiaojuan Xi, Hongkai Gao, Lan Wang-Erlandsson, Jianzhi Dong, Fabrizio Fenicia, Hubert H G Savenije, Markus Hrachowitz
{"title":"Terrestrial ecosystems enhanced root zone water storage capacity in response to climate change over the past four decades.","authors":"Qiaojuan Xi, Hongkai Gao, Lan Wang-Erlandsson, Jianzhi Dong, Fabrizio Fenicia, Hubert H G Savenije, Markus Hrachowitz","doi":"10.1016/j.scib.2025.06.027","DOIUrl":"https://doi.org/10.1016/j.scib.2025.06.027","url":null,"abstract":"<p><p>Adaptation of ecosystems' root zones to climate change critically affects drought resilience and vegetation productivity. However, a global quantitative assessment of this mechanism is missing. In this study, we analyzed high-quality observation-based data to find that the global average root zone water storage capacity (S<sub>R</sub>) increased by 11%, from 182 to 202 mm in 1982-2020. The total increase of S<sub>R</sub> equals to 1652 billion m<sup>3</sup> over the past four decades. S<sub>R</sub> increased in 9 out of 12 land cover types, while three relatively dry types experienced decreasing trends, potentially suggesting the crossing of ecosystems' tipping points. Our results underscore the importance of accounting for root zone dynamics under climate change to assess drought impacts.</p>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Local regulation and global reconstruction of polar networks in twisted bilayer MoS2. 扭曲双层二硫化钼极性网络的局部调控与全局重构。
IF 18.8 1区 综合性期刊
Science Bulletin Pub Date : 2025-06-21 DOI: 10.1016/j.scib.2025.06.026
Jiakai Wang, Xu Han, Guanchu Liu, Zihao Guo, Longshuo Gu, Jiahao Yan, Shiqi Yang, Chunsheng Hu, Chicheng Liu, Yunyun Dai, Xia Liu, Yuan Huang, Yeliang Wang
{"title":"Local regulation and global reconstruction of polar networks in twisted bilayer MoS<sub>2</sub>.","authors":"Jiakai Wang, Xu Han, Guanchu Liu, Zihao Guo, Longshuo Gu, Jiahao Yan, Shiqi Yang, Chunsheng Hu, Chicheng Liu, Yunyun Dai, Xia Liu, Yuan Huang, Yeliang Wang","doi":"10.1016/j.scib.2025.06.026","DOIUrl":"https://doi.org/10.1016/j.scib.2025.06.026","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lipid droplet clearance inhibits esophageal cancer growth via metabolic reprogramming. 脂滴清除通过代谢重编程抑制食管癌生长。
IF 18.8 1区 综合性期刊
Science Bulletin Pub Date : 2025-06-21 DOI: 10.1016/j.scib.2025.06.029
Yan Pu, Yi Wan, Yuhua Fu, Kai Li, Yijiao Chen, Yunzhi Wang, Bin Li, Lingling Li, Zhaoyu Qin, Jingyan Xu, Dongxian Jiang, Yan Li, Guoying Yu, Gang Sun, Boxun Lu, Wenjun Yang, Chen Ding
{"title":"Lipid droplet clearance inhibits esophageal cancer growth via metabolic reprogramming.","authors":"Yan Pu, Yi Wan, Yuhua Fu, Kai Li, Yijiao Chen, Yunzhi Wang, Bin Li, Lingling Li, Zhaoyu Qin, Jingyan Xu, Dongxian Jiang, Yan Li, Guoying Yu, Gang Sun, Boxun Lu, Wenjun Yang, Chen Ding","doi":"10.1016/j.scib.2025.06.029","DOIUrl":"https://doi.org/10.1016/j.scib.2025.06.029","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RG7388 inhibits SFTSV replication by suppressing MDM2-mediated p53 degradation and preventing apoptosome disruption. RG7388通过抑制mdm2介导的p53降解和防止凋亡中断来抑制SFTSV复制。
IF 18.8 1区 综合性期刊
Science Bulletin Pub Date : 2025-06-21 DOI: 10.1016/j.scib.2025.06.028
Zixiang Liu, Mengqian Huang, Yuyang Liu, Luna Cui, Xixi Shi, Honghua Chen, Xiaoning Gao, Zining Wang, Qinting Lin, Zhiyun Wang, Yue Teng, Tao Wang
{"title":"RG7388 inhibits SFTSV replication by suppressing MDM2-mediated p53 degradation and preventing apoptosome disruption.","authors":"Zixiang Liu, Mengqian Huang, Yuyang Liu, Luna Cui, Xixi Shi, Honghua Chen, Xiaoning Gao, Zining Wang, Qinting Lin, Zhiyun Wang, Yue Teng, Tao Wang","doi":"10.1016/j.scib.2025.06.028","DOIUrl":"https://doi.org/10.1016/j.scib.2025.06.028","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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