Science Bulletin最新文献

{"title":"Diurnal double-pulse of nitrate dynamics in Mount Qomolangma glacial runoff","authors":"Dandan Yang,&nbsp;Lin Li,&nbsp;Tandong Yao,&nbsp;Baiqing Xu,&nbsp;Jing Gao,&nbsp;He Sun,&nbsp;Dongmei Qu","doi":"10.1016/j.scib.2026.02.009","DOIUrl":"10.1016/j.scib.2026.02.009","url":null,"abstract":"<div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (146KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 19","pages":"Pages 4857-4860"},"PeriodicalIF":20.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147281575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Late-spring vertical profiles in atmospheric water vapor stable isotopes reveal westerlies moisture transport across the Himalaya into the Asian Water Towers","authors":"Jing Gao,&nbsp;Jingjing Yang,&nbsp;Gebanruo Chen,&nbsp;Yigang Liu,&nbsp;Xiaowei Niu,&nbsp;Aibin Zhao,&nbsp;Yilong Wang,&nbsp;Rong Cai,&nbsp;Zeqing He,&nbsp;Taihua Zhang,&nbsp;Tandong Yao","doi":"10.1016/j.scib.2026.05.043","DOIUrl":"10.1016/j.scib.2026.05.043","url":null,"abstract":"<div><div>Moisture carried by the mid-latitude westerlies is an important source of water for the Asian Water Towers (AWTs), but how this moisture crosses the high Himalaya has remained unclear. Here, we use a tethered balloon to measure atmospheric water vapor and its isotopic compositions (<em>δ</em>D_v and <em>d</em>-excess_v) from the surface to 9050 m above sea level in late spring (May 2022) on the northern side of Mt. Qomolangma. These measurements show that the westerlies can transport moisture from the south of the Himalaya across the high-altitude barrier, particularly above 7000 m above sea level, into the AWTs. By combining our observations with atmospheric model simulations, we show that the water vapor becomes strongly depleted in heavy isotopes during transport, primarily due to rapid cooling and ice formation high above the mountains. These results provide the first direct evidence, for late spring over the Mt. Qomolangma region, of how moisture from distant ocean regions can reach the interior of the AWTs. Our findings provide an unprecedented understanding of the westerlies advection across the Himalayas in late spring and a benchmark for future climate projections. They also highlight that the interpretation of isotopic records in Himalayan ice cores should consider the influence of multi-sources and kinetic effects aloft in the AWTs.</div></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 19","pages":"Pages 4874-4883"},"PeriodicalIF":20.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148194438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genomic and genetic insights into the divergence between indica and japonica rice","authors":"Xiangxi Zhuansun,&nbsp;Wenlong Guo,&nbsp;Siqi Xia,&nbsp;Jun Shu,&nbsp;Kai Wang,&nbsp;Qiyu Zhang,&nbsp;Hao Wen,&nbsp;Lina Du,&nbsp;Siyu Wen,&nbsp;Ge Gao,&nbsp;Junran Wang,&nbsp;Dan Wang,&nbsp;Yuhang Zhang,&nbsp;Jun Yang,&nbsp;Jiyue Qiao,&nbsp;Bin Zhang,&nbsp;Bi Wu,&nbsp;Youlin Peng,&nbsp;Jian Sun,&nbsp;Longjiang Fan,&nbsp;Xiaoming Zheng","doi":"10.1016/j.scib.2026.07.009","DOIUrl":"10.1016/j.scib.2026.07.009","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 19","pages":"Pages 4884-4887"},"PeriodicalIF":20.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148534789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineering reverse H-spillover on Ru single-atom sites for selective upgrading of lignin-oil to aviation fuel precursors","authors":"Jinpeng Wei,&nbsp;Yonggang Sun,&nbsp;Wenjin Shi,&nbsp;Yuyu Wang,&nbsp;Yulong Ma,&nbsp;Zhengping Hao","doi":"10.1016/j.scib.2026.08.027","DOIUrl":"10.1016/j.scib.2026.08.027","url":null,"abstract":"<div><div>Lignin-oil remains the last untapped carbon reservoir in biomass refineries because its dense aryl–O–aryl networks resist selective C–O cleavage. The key to this transformation lies in the selective deoxygenation of its oxygen-containing groups and the selective scission of bonds between polycyclic aromatic hydrocarbons; whether the surface can return H* to metal centres to trigger cracking is unknown. Here we elucidate a reverse H-spillover pathway on Ru single-atom catalysts (Ru₁/WZrO<em>_x</em>) that enables C–O cleavage of crude lignin-oil directly to produce value-added aviation fuel precursors, boosting the hydrodeoxygenation efficiency by 40%. Surprisingly, a remarkable substrate conversion of 100% and selectivity of 100% to produce cycloalcohols are achieved, while delivering an impressive 80.7% selectivity toward C–O cleavage from lignin-oil. Detailed spectroscopy, isotope experiments and density functional theory analysis disclose that sp³-hybridized W centres in defective WZrO<em>_x</em> nanolattices chemically push electron-rich hydrides back to Ru single-atoms, while micro-kinetics of dual-supplied H* system identify a 0.09 eV barrier for arene–O hydrogenolysis inside a Ru-hydride, leading to highly active lignin-oil hydrocracking. This study is expected to provide deep insights into boosting efficient lignin-oil depolymerization via modulating the surface active sites of the catalyst, for converting lignin-oil into hydrocarbon mixtures suitable for aviation fuel.</div></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 19","pages":"Pages 4966-4980"},"PeriodicalIF":20.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148849537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A unified solution to the low-mass X-ray binary diversity puzzle: saturated magnetic braking coupled with irradiation-driven winds","authors":"Zhu-Ling Deng,&nbsp;Xiang-Dong Li,&nbsp;Bo Wang,&nbsp;Philipp Podsiadlowski,&nbsp;Yong Shao,&nbsp;Dong-Dong Liu,&nbsp;Zhan-Wen Han","doi":"10.1016/j.scib.2026.08.068","DOIUrl":"10.1016/j.scib.2026.08.068","url":null,"abstract":"<div><div>The standard magnetic braking (MB) model has long failed to explain key properties of low-mass X-ray binaries (LMXBs) — including their accretion rates, the formation of ultracompact binaries, and orbital expansion — casting doubt on binary evolution and gravitational-wave progenitor predictions. Phenomenological modifications exist, but a unified, physically grounded mechanism has been missing. Here we show that the overlooked coupling between magnetic saturation and irradiation-driven winds (IDW) provides this missing framework. Accretion-powered irradiation enhances the donor wind, which in turn amplifies MB exactly where needed. Our Saturated MB  + IDW (SMB + IDW) model simultaneously resolves three outstanding discrepancies with no fine-tuning: (1) it reproduces the full observed distribution of accretion rates across persistent and transient LMXBs; (2) it naturally explains ultracompact X-ray binary formation; and (3) it quantitatively matches the orbital period distribution of descendant millisecond pulsar (MSP) binaries — a critical independent test failed by all previous models. Critically, the SMB + IDW model transforms MB from an externally imposed condition into a self-consistently regulated process tied to the accretion history. By unifying LMXB evolution to MSPs in a single physical picture, our work resolves the long-standing diversity puzzle and establishes a physics-based foundation for next-generation population synthesis, gravitational-wave progenitor predictions, and compact binary interpretation across cosmic time.</div></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 19","pages":"Pages 4937-4948"},"PeriodicalIF":20.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148987595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Earth summit observations to decode environmental changes on Mount Qomolangma","authors":"Tandong Yao,&nbsp;Baosheng An,&nbsp;Weicai Wang","doi":"10.1016/j.scib.2026.09.026","DOIUrl":"10.1016/j.scib.2026.09.026","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 19","pages":"Pages 4851-4853"},"PeriodicalIF":20.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148987598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deuterium engineering unlocks a tripartite enhancement in a NIR-Ⅱ AIEgen for exceptional cancer theranostics and surgical navigation","authors":"Shuo Xiang,&nbsp;Jun Zhu,&nbsp;Caifa You,&nbsp;Yong Tian,&nbsp;Dingyuan Yan,&nbsp;Lei Wang,&nbsp;Dong Wang,&nbsp;Ben-Zhong Tang","doi":"10.1016/j.scib.2026.08.045","DOIUrl":"10.1016/j.scib.2026.08.045","url":null,"abstract":"<div>Deuterium engineering is employed to unlock a tripartite enhancement in NIR-Ⅱ AIEgens. This approach simultaneously boosts fluorescence quantum yield, reactive oxygen species (ROS) generation, and physiological stability while retaining photothermal efficiency. The resulting nanoparticles enable trimodal imaging and synergistic phototherapy for complete tumor ablation, and also facilitate high-contrast fluorescence-guided surgical resection of colorectal cancer, significantly prolonging survival <em>in vivo.</em></div><div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (192KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 19","pages":"Pages 4912-4916"},"PeriodicalIF":20.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148890640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumor-confined nano-activators for antigen-independent broad activation of tumor-infiltrating T cells","authors":"Yue Wang,&nbsp;Min Yang,&nbsp;Bao-Yue Zhang,&nbsp;Mei-Tang Peng,&nbsp;Yi-Qun Sun,&nbsp;Shi-Kun Zhou,&nbsp;Wei Li,&nbsp;Xian-Zhu Yang,&nbsp;Shi-Dang Xu,&nbsp;Zi-Dong Lu,&nbsp;Cong-Fei Xu,&nbsp;Jun Wang","doi":"10.1016/j.scib.2026.07.061","DOIUrl":"10.1016/j.scib.2026.07.061","url":null,"abstract":"<div><div>Cancer vaccines hold strong therapeutic promise, but their development is often hindered by the need to identify effective tumor antigens—a challenge amplified by tumor heterogeneity. Here, we report a tumor-confined nano-activator (iCLAN_TSP-SAg) that circumvents antigen dependence by driving localized expression of bacterial superantigens (SAgs) within tumors. This platform integrates tumor-specific promoter-driven SAg plasmids with lipid-assisted polymeric nanoparticles to enable efficient cytosolic delivery and tumor-restricted SAg production. The locally expressed SAgs elicit broad, antigen-independent activation of intratumoral CD4⁺ and CD8⁺ T cells through direct crosslinking of T-cell receptors and major histocompatibility complex class II molecules. By confining SAg expression to the tumor site, iCLAN_TSP-SAg minimizes systemic T-cell activation and off-target toxicity. When co-administered with anti-PD-1 antibodies, iCLAN_TSP-SAg eliminates established tumors in two-thirds of treated mice and induces durable immune memory that confers complete protection upon rechallenge. This strategy offers a potent and clinically translatable solution to the central challenge of antigen identification in cancer vaccine development.</div></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 19","pages":"Pages 5012-5025"},"PeriodicalIF":20.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148721220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On-chip squeezed light in the audio frequency band","authors":"Xuezhi Zhu,&nbsp;Yunyun Cao,&nbsp;Rui Liu,&nbsp;Yaya He,&nbsp;Fan Zhang,&nbsp;Yaqing Zhang,&nbsp;Shiwei Du,&nbsp;Meihong Wang,&nbsp;Xiaoshun Jiang,&nbsp;Xiaolong Su","doi":"10.1016/j.scib.2026.08.054","DOIUrl":"10.1016/j.scib.2026.08.054","url":null,"abstract":"<div><div>Squeezed light in the audio-frequency band is a key resource for quantum metrology and quantum sensing. However, realizing stable audio-frequency squeezed light on integrated photonic platforms remains challenging due to technical noise and the difficulty of scalable phase referencing. Here, we demonstrate on-chip generation of audio-band two-mode squeezed states down to 60 Hz in a silica microcavity. To enable phase-stable operation without directly locking fragile quantum modes, we develop a coherent-comb control method in which a weak electro-optic reference comb co-propagates with the vacuum at the quantum frequency modes in an orthogonal polarization. This scheme provides quadrature measurement and long-timescale phase stability, thereby enabling covariance-matrix reconstruction. We verify the entanglement with the positive partial transposition criterion, which confirms inseparability via a minimum symplectic eigenvalue of 0.395 (<span><math><mrow><mo>&lt;</mo></mrow></math></span>0.5). Our results establish an experimentally accessible route toward on-chip phase-stable audio-band squeezing and support the scalable framework for continuous-variable quantum information processing with integrated photonics.</div></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 19","pages":"Pages 4949-4955"},"PeriodicalIF":20.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148918050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A bio-orthogonally engineered probiotic-T cell chimera amplifies adoptive cell therapy through spatial DC-T cell immune licensing","authors":"Jingwen Shen,&nbsp;Yanhong Chu,&nbsp;Yan Wang,&nbsp;Xinyi Chen,&nbsp;Yaohua Ke,&nbsp;Da Huo,&nbsp;Junmeng Zhu,&nbsp;Sen Hong,&nbsp;Sizhe Qin,&nbsp;Baorui Liu,&nbsp;Qin Liu","doi":"10.1016/j.scib.2026.09.009","DOIUrl":"10.1016/j.scib.2026.09.009","url":null,"abstract":"<div><div>Adoptive cell transfer (ACT) has achieved durable clinical responses in hematological malignancies, yet remains limited in solid tumors owing to poor T cell infiltration, inadequate persistence, and tumor-driven immunosuppression. Here, we report a bio-orthogonally engineered probiotic-T cell chimera (T-FOLactis) that creates a mutually reinforcing cellular-microbial system, in which FOLactis, an engineered <em>Lactococcus lactis</em> expressing a Flt3L-OX40L fusion protein, provides localized immunostimulatory cues to enhance T cell activation and effector function, while adoptively transferred T cells serve as cytotoxic effectors and mobile carriers that facilitate delivery of the bacterial payload to the tumor microenvironment. Using strain-promoted azide-alkyne cycloaddition chemistry, FOLactis bacteria were covalently anchored onto the surface of T cells, generating a cell-bound platform for spatially restricted immune modulation. In syngeneic colorectal cancer models, T-FOLactis reduced tumor burden by 78.1% compared with saline-treated controls and by 65.0% relative to conventional ACT, while prolonging median survival from 22 to 46 d without overt systemic toxicity. Mechanistically, T-FOLactis promoted dendritic cell (DC)-T cell proximity and established a spatially organized immune-licensing niche that amplified the functional impact of FOLactis-induced inflammatory cues, including IL-18. This spatial configuration was associated with enhanced coupling of cytokine availability, DC maturation, local co-stimulation and cytotoxic CD8⁺ T cell effector programming. IL-18 blockade impaired this licensing program and reduced therapeutic benefit, supporting IL-18 as a key functional mediator within the DC-T cell licensing niche. Together, these findings establish a modular cell-surface engineering strategy for augmenting ACT in colorectal cancer through coordinated immune network engagement.</div></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 19","pages":"Pages 5073-5089"},"PeriodicalIF":20.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148987600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}