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Integrative analysis of copper dysregulation and cuproptosis in postnatal hematopoiesis. 出生后造血中铜异常与铜增生的综合分析。

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2025-05-16 DOI: 10.1016/j.scib.2025.05.019

Liyun Chen, Qian Wu, Chaohui Lin, Zijun Song, Yunxing Su, Chaodong Ge, Xue Wang, Hongbing Luo, Rong Wang, Yanfang Wang, Junxia Min, Fudi Wang

{"title":"Integrative analysis of copper dysregulation and cuproptosis in postnatal hematopoiesis.","authors":"Liyun Chen, Qian Wu, Chaohui Lin, Zijun Song, Yunxing Su, Chaodong Ge, Xue Wang, Hongbing Luo, Rong Wang, Yanfang Wang, Junxia Min, Fudi Wang","doi":"10.1016/j.scib.2025.05.019","DOIUrl":"https://doi.org/10.1016/j.scib.2025.05.019","url":null,"abstract":"Copper dysregulation has been linked to human health, disorders, and hematopoiesis. However, the underlying mechanisms remain elusive. Here, we demonstrate the pivotal role of dietary copper via the transporter Slc31a1(Ctr1) in copper homeostasis, but not cuproptosis, during postnatal hematopoiesis. Specifically, Slc31a1-mediated copper uptake sustains the differentiation and commitment of multipotent progenitors from short-term hematopoietic stem cells (HSCs). Using transcriptomic analyses, we reveal a disrupted differentiation program in hematopoietic stem and progenitor cells (HSPCs) in diet-induced copper-deficient mice or hematopoietic-specific Slc31a1 knockout (vKO) mice. Further, we show that Slc31a1 and copper are indispensable for sustaining mitochondrial activity via regulating Mtco1 and Mtco2 (subunits of Complex IV) within HSPCs. Notably, we show that the chemical compound elesclomol, also well-known as a potent cuproptosis agonist, significantly alleviates severe anemia and partially recovers HSPC mitochondrial function in vKO mice via its activity as a copper ionophore, but with no effect on cuproptosis. We thus renamed elesclomol as CupriActivitor1(CuA1), which is a more specific and descriptive term. These findings demonstrate the critical role and mechanism of copper, Slc31a1, and CuA1 in maintaining HSC homeostasis via modulation of mitochondrial energy metabolism. The study sheds light on the molecular basis of HSC fate decisions by copper or CuA1 and opens new avenues for the development of novel therapeutic strategies for copper-related disorders and blood diseases. Given the critical and multifaceted nature of copper, we propose establishing a novel interdisciplinary field termed \"Cuprology\". This discipline will advance our understanding of copper's roles in physiological and pathological processes.","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144232868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intermittent fasting and cardiovascular health: a circadian rhythm-based approach. 间歇性禁食和心血管健康：基于昼夜节律的方法。

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2025-05-15 DOI: 10.1016/j.scib.2025.05.017

Jiawen Zhang, Yifan Chen, Yiming Zhong, Yuehong Wang, Honghao Huang, Wei Xu, Wenhai Pan, Lei Chen, Yichun Zhu, Evelyne Bischof, Jun Pu

{"title":"Intermittent fasting and cardiovascular health: a circadian rhythm-based approach.","authors":"Jiawen Zhang, Yifan Chen, Yiming Zhong, Yuehong Wang, Honghao Huang, Wei Xu, Wenhai Pan, Lei Chen, Yichun Zhu, Evelyne Bischof, Jun Pu","doi":"10.1016/j.scib.2025.05.017","DOIUrl":"https://doi.org/10.1016/j.scib.2025.05.017","url":null,"abstract":"Intermittent fasting (IF) is increasingly recognized as an effective dietary intervention for slowing aging process and alleviating metabolic disturbances in multiple chronic diseases, especially in cardiovascular diseases (CVDs). Despite recent progress, the mechanisms behind its effects on cardiovascular health from the perspective of circadian rhythms are not yet fully understood. This review aims to explore the interaction between IF and circadian rhythms, focusing on their combined effects on cardiometabolic risks and cardiovascular outcomes. Evidence from animal models and clinical trials suggests that IF provides protective effects against cardiac damage and dysfunction. It is also indicated that IF influences key cardiometabolic risk factors, such as insulin sensitivity, inflammation, and lipid metabolism, by aligning with the intrinsic biological rhythms. Additionally, we discuss the therapeutic potential of IF in cardiovascular outcomes, particularly in individuals with circadian disruptions. This review also highlights future research directions to identify the most effective fasting protocols and assess the long-term cardiovascular benefits of IF in disease prevention and treatment.","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144245528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bionic-structured electromagnetic interference shielding composites. 仿生结构电磁干扰屏蔽复合材料。

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2025-05-15 DOI: 10.1016/j.scib.2025.04.074

Minzi Zhai, Sijin Zhao, Hua Guo, Xiangcheng Li, Xuetao Shi, Mukun He, Yali Zhang, Junwei Gu

{"title":"Bionic-structured electromagnetic interference shielding composites.","authors":"Minzi Zhai, Sijin Zhao, Hua Guo, Xiangcheng Li, Xuetao Shi, Mukun He, Yali Zhang, Junwei Gu","doi":"10.1016/j.scib.2025.04.074","DOIUrl":"https://doi.org/10.1016/j.scib.2025.04.074","url":null,"abstract":"As electromagnetic pollution intensifies and the demand for high-precision electronic equipment increases, the development of high-performance, adaptable electromagnetic interference (EMI) shielding materials with high-performance and adaptability has become a research focus. Inspired by natural structures, bionic designs offer unique advantages for the fabrication of advanced EMI shielding materials. These materials provide effective electromagnetic wave attenuation and are lightweight, flexible, and environmentally adaptable, thereby overcoming the limitations of traditional EMI shielding materials. This review systematically summarises the latest advancements in bionic-structured EMI shielding composites. This paper first introduces the design principles of bionic structures and then focuses on typical bioinspired systems, including nacre, honeycomb, leaf vein structures, and other nature-inspired structures. This review further explores common fabrication techniques and the structure-property relationships of materials with such structures, with a particular focus on performance optimisation strategies. Additionally, we examine the conformational relationships and underlying mechanisms governing the performance enhancements of bionic-structured EMI shielding composites. The challenges and future prospects of bionic-structured EMI shielding composites are also analyzed. This review aims to provide theoretical insights into structural innovation and performance enhancement, promoting the application of bionic-structured EMI shielding composites in aerospace, smart wearables, and medical electronics. This paper is expected to pave the way for the development of next-generation electromagnetic protection materials.","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intrinsically soft and fully recyclable robotic sensors with quadruple sensing functions for reliable human-robot interactions. 本质上柔软和完全可回收的机器人传感器，具有可靠的人机交互的四重传感功能。

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2025-05-15 DOI: 10.1016/j.scib.2025.04.075

Yuexin Cao, Yuxiang Peng, Wenjuan Ren, Honghao Wang, Yan Diao, Zhimeng Liu, Xin He, Hua Luo, Xiaodong Wu

{"title":"Intrinsically soft and fully recyclable robotic sensors with quadruple sensing functions for reliable human-robot interactions.","authors":"Yuexin Cao, Yuxiang Peng, Wenjuan Ren, Honghao Wang, Yan Diao, Zhimeng Liu, Xin He, Hua Luo, Xiaodong Wu","doi":"10.1016/j.scib.2025.04.075","DOIUrl":"https://doi.org/10.1016/j.scib.2025.04.075","url":null,"abstract":"Human-robot interaction (HRI) is becoming ubiquitous where both humans and robots perform tasks, while reliable robotic sensors are the prerequisite for efficient and safe HRI, especially in unstructured or dynamic environments. A wide spectrum of robotic sensors has been developed but most of them are limited to single or dual functionality, making it challenging to perceive complex environments. Here, we present a type of intrinsically soft robotic sensor with quadruple sensing functionalities integrated into a single device, including spatial approach sensing, thermal approach sensing, thermal touch sensing, and mechanical force sensing. Through such quadruple sensing functions, both thermal and mechanical stimulations can be well resolved in both contact and non-contact manners. More importantly, all components of the robotic sensors can be fully recycled for reuse upon the sensor's end of service, achieving superior cost-efficiency and eco-sustainability. As demonstrations, a close-loop intelligent HRI system is constructed via integrating our intrinsically soft sensors with pneumatic soft grippers and programmable robotic arms. A diversity of reliable HRI scenarios (e.g., human-robot interfacing, object perception/classification, bedside clinical care, etc.) are successfully demonstrated leveraging the quadruple sensing functionalities. This study presents a new path to enrich robotic sensing functionality and enhance HRI reliability in complex environments.","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Large-scale optimized deployment of bioenergy with carbon capture and storage in China. 中国生物能源与碳捕获与封存的大规模优化部署。

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2025-05-14 DOI: 10.1016/j.scib.2025.05.018

Wenhao Lin, Lei Gao, Zhaoxia Guo, Yucheng Dong, Yinfeng Xu, Enayat A Moallemi, Gang Kou, Meiqian Chen, Ke Li, Weijun Xu, Raymundo Marcos-Martinez, Brett A Bryan

引用次数: 0

Sterilized protective immunity induced by DAM and DAM⁺ in mouse models for both VACV and MPXV. DAM和DAM+在小鼠模型中对VACV和MPXV诱导的无菌保护性免疫。

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2025-05-14 DOI: 10.1016/j.scib.2025.05.013

Zhengrong Gao, Tingting Zheng, Jiahao Wu, Haoyi Ding, Jia Lu, Jiahui Si, Yuze Xu, Hao Liu, Guocan Yu, Renyi Ma, Jianxun Qi, Yunfei Zhao, Jiaqi Ran, Qihui Wang, Xiaopeng Ma, Zhida Liu, Han Wang, George Fu Gao

{"title":"Sterilized protective immunity induced by DAM and DAM+ in mouse models for both VACV and MPXV.","authors":"Zhengrong Gao, Tingting Zheng, Jiahao Wu, Haoyi Ding, Jia Lu, Jiahui Si, Yuze Xu, Hao Liu, Guocan Yu, Renyi Ma, Jianxun Qi, Yunfei Zhao, Jiaqi Ran, Qihui Wang, Xiaopeng Ma, Zhida Liu, Han Wang, George Fu Gao","doi":"10.1016/j.scib.2025.05.013","DOIUrl":"https://doi.org/10.1016/j.scib.2025.05.013","url":null,"abstract":"The increasing prevalence of mpox calls for the development of safer and more accessible next-generation vaccines. Based on a structure-guided \"two-in-one\" immunogen design strategy, we have previously developed an innovative protein-based monkeypox virus (MPXV) vaccine, DAM, which addresses the issues of imbalanced bioavailability associated with cocktail vaccines and elicits superior antiviral immunity with a safety profile. In this study, we iteratively designed two \"four-in-one\" chimeric immunogens, DAM+s, using four MPXV antigens, M1, A29, A35, and B6. Although DAM+s elicited broader immune responses against four antigens, no additional benefit in either in vitro neutralization or in vivo protection against poxviruses was detected compared to DAM. Notably, vaccination-related tissue damage was observed in the live virus vaccine group, whereas all protein-based vaccines showed better safety and protection against lethal vaccinia virus (VACV) challenge. Together, these further demonstrate that DAM, with a minimal protein subunit of two components, is a promising immunogen to be further clinically developed.","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144245532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The ultrastructure of the Cretaceous feathers highlights the evolution of the feather. 白垩纪羽毛的超微结构突出了羽毛的演化。

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2025-05-13 DOI: 10.1016/j.scib.2025.04.073

Jiajia Wang, Rui Qiu, Qian Chen, Di Liu, Tongbo Zhang, Ying Li, Xinjun Zhang, Baopeng Wang, Dongyu Hu, Dong Ren, Xiaolin Wang, Xiaofei Xia, Yuguang Zhang, Weiting Zhang, Ming Bai

引用次数: 0

Dynamic ventilation functional MRI of the lung with sub-millimeter spatial resolution and millisecond temporal resolution. 亚毫米空间分辨率和毫秒时间分辨率的肺动态通气功能MRI。

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2025-05-13 DOI: 10.1016/j.scib.2025.05.014

Hongchuang Li, Haidong Li, Li Fan, Ming Zhang, Xiaoling Liu, Xiuchao Zhao, Yeqing Han, Yang Jin, Louis-S Bouchard, Shiyuan Liu, Xin Zhou

引用次数: 0

Heterogeneous Rb-Sr isotopes in Chang'e-5/6 soils: implication for geochemical study of extraterrestrial samples. 嫦娥5/6号土壤非均相Rb-Sr同位素：对地外样品地球化学研究的意义

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2025-05-13 DOI: 10.1016/j.scib.2025.04.072

Le Zhang, Guanhong Zhu, Zhiming Chen, Jingyou Chen, Yan-Qiang Zhang, Zexian Cui, Chengyuan Wang, Haiyang Xian, Xianglin Tu, Jintuan Wang, Qing Yang, Ya-Nan Yang, Pengli He, Fangfang Huang, Linli Chen, Yi-Gang Xu

引用次数: 0

Plant-microbe diplomacy: managing microbial relationships. 植物-微生物外交：管理微生物关系。

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2025-05-12 DOI: 10.1016/j.scib.2025.05.016

Marco Giovannetti, Andrea Genre

引用次数: 0