Science Bulletin最新文献_第3页

Important role of Marine Group II Euryarchaeota in organic carbon cycling in the South China Sea. 海洋第二类极毛虫在南海有机碳循环中的重要作用。

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2024-11-26 DOI: 10.1016/j.scib.2024.11.034

Ye Lu, Qian Li, Duo Zhao, Yao Zhang

引用次数: 0

An electrically activable nanochip to intensify gas-ionic-immunotherapy.

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2024-11-26 DOI: 10.1016/j.scib.2024.11.035

Gang Wang, Jingrui Li, Shumin Sun, Yuqi Yang, Zhihui Han, Zifan Pei, Liang Cheng

{"title":"An electrically activable nanochip to intensify gas-ionic-immunotherapy.","authors":"Gang Wang, Jingrui Li, Shumin Sun, Yuqi Yang, Zhihui Han, Zifan Pei, Liang Cheng","doi":"10.1016/j.scib.2024.11.035","DOIUrl":"https://doi.org/10.1016/j.scib.2024.11.035","url":null,"abstract":"Excess intracellular H2S induces destructive mitochondrial toxicity, while overload of Zn2+ results in cell pyroptosis and potentiates the tumor immunogenicity for immunotherapy. However, the precise delivery of both therapeutics remains a great challenge. Herein, an electrically activable ZnS nanochip for the controlled release of H2S and Zn2+ was developed for enhanced gas-ionic-immunotherapy (GIIT). Under an electric field, a locality with particularly high concentrations of H2S and Zn2+ was established by the voltage-controlled degradation of the ZnS nanoparticles (NPs). Consequently, the ZnS nanochip-mediated gas-ionic therapy (GIT) resulted in mitochondrial membrane potential depolarization, energy generation inhibition, and oxidative stress imbalance in tumor cells. Interestingly, the cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes (cGAS-STING) signaling pathway was activated due to the mitochondrial destruction. Moreover, the released Zn2+ resulted in the increase of the intracellular Zn levels and cell pyroptosis, which enhanced the immunogenicity via the release of damage-associated molecular patterns (DAMPs). In vitro and in vivo studies revealed that the ZnS nanochip-based GIT effectively eliminated the tumors under an electric field and mobilized the cytotoxic T lymphocytes for immunotherapy. The combination with αCTLA-4 further promoted the adaptive immune response and inhibited tumor metastasis and long-term tumor recurrence. This work presented an electrically activable ZnS nanochip for combined immunotherapy, which might inspire the development of electric stimulation therapy.","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142816958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decoding blast resistance: a deep dive into the broad-spectrum resistance gene Pi-ta locus through functional analysis of Ptr alleles.

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2024-11-26 DOI: 10.1016/j.scib.2024.11.036

Huanbin Shi, Jiehua Qiu, Peisong Hu, Naweed I Naqvi

引用次数: 0

Psychedelics for treating psychiatric disorders: From circuit mechanisms to applications.

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2024-11-26 DOI: 10.1016/j.scib.2024.11.033

Jie Li, Yuting Jiang, Dan Cheng, Jianjun Cheng, Ji Hu, Xiaohui Wang, Ti-Fei Yuan

引用次数: 0

Transforming osteosarcoma care: from historical milestones to precision medicine advances.

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2024-11-23 DOI: 10.1016/j.scib.2024.11.027

Jichuan Wang, David S Geller, Luyang Sun, Xiaodong Tang

引用次数: 0

Dual inhibition of PD-1 and LAG-3: uncovering mechanisms to reverse T cell exhaustion and enhance anti-tumor immunity.

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2024-11-22 DOI: 10.1016/j.scib.2024.11.029

Xiaoxue Zhou, Fangfang Zhou, Long Zhang

引用次数: 0

Double-edged impact of climate change on global solar power.

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2024-11-22 DOI: 10.1016/j.scib.2024.11.030

Ning Lu, Jun Qin

引用次数: 0

Hydrogel-filled micropipette enables antifouling in vivo iontronic sensing.

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2024-11-22 DOI: 10.1016/j.scib.2024.11.028

Guangguo Guo, Yifei Pan, Tianyi Xiong, Wenliang Ji, Wenjie Ma, Ping Yu, Yuqing Lin, Lanqun Mao

引用次数: 0

Planar Hall plateau in magnetic Weyl semimetals.

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2024-11-22 DOI: 10.1016/j.scib.2024.11.026

Lei Li, Chaoxi Cui, Run-Wu Zhang, Zhi-Ming Yu, Yugui Yao

{"title":"Planar Hall plateau in magnetic Weyl semimetals.","authors":"Lei Li, Chaoxi Cui, Run-Wu Zhang, Zhi-Ming Yu, Yugui Yao","doi":"10.1016/j.scib.2024.11.026","DOIUrl":"https://doi.org/10.1016/j.scib.2024.11.026","url":null,"abstract":"Despite the rapid progress in the study of planar Hall effect (PHE) in recent years, all the previous works only showed that the PHE is connected to local geometric quantities, such as Berry curvature. Here, for the first time, we point out that the PHE in magnetic Weyl semimetals is directly related to a global quantity, namely, the Chern number of the Weyl point. This leads to a remarkable consequence that the PHE observation predicted here is robust against many system details, including the Fermi energy. The main difference between non-magnetic and magnetic Weyl points is that the latter breaks time-reversal symmetry T, thus generally possessing an energy tilt. Via semiclassical Boltzmann theory, we investigate the PHE in generic magnetic Weyl models with energy tilt and arbitrary Chern number. We find that by aligning the magnetic and electric fields in the same direction, the trace of the PHE conductivity contributed by Berry curvature and orbital moment is proportional to the Chern number and the energy tilt of the Weyl points, resulting in a previously undiscovered quantized PHE plateau by varying the Fermi energy. We further confirm the existence of PHE plateaus in a more realistic lattice model without T symmetry. By proposing a new quantized physical quantity, our work not only provides a new tool for extracting the topological character of the Weyl points but also suggests that the interplay between topology and magnetism can give rise to intriguing physics.","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142790910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single-layer MoS₂/graphene-based stable on-chip Zn-ion microbattery for monolithically integrated electronics. 基于单层 MoS2/石墨烯的稳定片上 Zn 离子微型电池，用于单片集成电子器件。

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2024-11-19 DOI: 10.1016/j.scib.2024.11.023

Jipeng Chen, Wenbo Zhao, Yong Gao, Fan Bu, Penghui Wu, Yue Xiang, John Wang, Xiangye Liu, Cao Guan

{"title":"Single-layer MoS2/graphene-based stable on-chip Zn-ion microbattery for monolithically integrated electronics.","authors":"Jipeng Chen, Wenbo Zhao, Yong Gao, Fan Bu, Penghui Wu, Yue Xiang, John Wang, Xiangye Liu, Cao Guan","doi":"10.1016/j.scib.2024.11.023","DOIUrl":"https://doi.org/10.1016/j.scib.2024.11.023","url":null,"abstract":"Self-powered microelectronics are essential for the sustained and autonomous operations of wireless electronics and microrobots. However, they are challenged by integratable microenergy supplies. Herein, we report a single-layer (SL) MoS2/graphene heterostructure for stable Zn-ion microbatteries. The MoS2/graphene heterostructure not only provides high chemical affinity for Zn and generates perfect lattice matching for Zn (002) deposition, but also facilitates homogeneous current density distribution. As a result, Zn metal is reversibly epitaxially plating/stripping at/from the heterostructure, without the formation of dendrites. The MoS2/graphene-based Zn||MnO2 microbattery with a tiny footprint area sub-0.1 mm2 shows a stable high capacity of 0.16 mAh cm-2 at 0.5 mA cm-2 within 470 cycles. Using a single piece of crystalline MoS2/graphene film, on-chip microbatteries and transistors were simultaneously fabricated via a facile lithography process, achieving highly integrated self-powered field-effect transistors and photodetector. The SL MoS2/graphene-based self-powered monolithically integrated microsystem paves a new way for the multi-functionalization and miniaturization of next-generation electronics.","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0