Science Bulletin最新文献

{"title":"Biodegradable piezoelectric suture for real-time biomechanical sensing and therapeutic intervention","authors":"Quanhong Hu,&nbsp;Chuyu Tang,&nbsp;Zhirong Liu,&nbsp;Shaobo Wang,&nbsp;Zhuo Wang,&nbsp;Genglin Chen,&nbsp;Shuncheng Yao,&nbsp;Zhuoheng Jiang,&nbsp;Songjing Zhong,&nbsp;Yuxuan Zhang,&nbsp;Linlin Li","doi":"10.1016/j.scib.2026.08.012","DOIUrl":"10.1016/j.scib.2026.08.012","url":null,"abstract":"<div><div>Sutures are a cornerstone of surgical procedures, yet conventional designs remain bioinert and mechanically rigid, failing to adapt to dynamic wound microenvironments and lacking the capability to sense mechanical forces. To overcome these limitations, we present a biodegradable piezoelectric suture (e-suture) that enables real-time monitoring of mechanical stress at the wound site while promoting tissue regeneration. A core-sheath architecture of the e-suture, combining a piezoelectric nanofibrous sheath with a flexible hydrogel electrode, ensures mechanical compliance with soft tissues and enables wireless real-time monitoring of wound biomechanics. Incorporation of quercetin (Que) into poly(L-lactic acid) (PLLA) nanofibers stabilizes the β-phase conformation of PLLA and enhances piezoelectric output through hydrogen-bonding interactions. In addition to electromechanical properties, Que confers intrinsic anti-oxidative and anti-inflammatory properties, actively suppressing excessive M1 macrophage polarization and pro-inflammatory cytokine secretion during wound healing. In rodent models of skin and muscle injury, the e-suture efficiently combined real-time mechanosensing, inflammation modulation, tissue regeneration, neovascularization, and collagen deposition. This platform bridges the gap between bioelectronics and wound therapeutics, offering a new paradigm for wound management.</div></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 19","pages":"Pages 4999-5011"},"PeriodicalIF":20.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chloroplast sunscreen: linking plant physiology with nanoassembly","authors":"Mingjing Cao,&nbsp;Chunying Chen","doi":"10.1016/j.scib.2026.08.046","DOIUrl":"10.1016/j.scib.2026.08.046","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 19","pages":"Pages 4894-4896"},"PeriodicalIF":20.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148872537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal PAN2 selectively maintains mRNA Poly(A) tail homeostasis to regulate RNA degradation during oocyte-to-early embryo transition in mice","authors":"Xuan Wu,&nbsp;Hua Zhang,&nbsp;Yu-Ke Wu,&nbsp;Zhuo-Yue Niu,&nbsp;Jing-Wen Liu,&nbsp;Lu Chen,&nbsp;Jia-Jia Cao,&nbsp;Yu-Ling Chen,&nbsp;Shu-Yan Ji,&nbsp;Fa-Long Lu,&nbsp;Heng-Yu Fan","doi":"10.1016/j.scib.2026.08.051","DOIUrl":"10.1016/j.scib.2026.08.051","url":null,"abstract":"<div><div>In mammals, the precise degradation of maternal mRNAs is essential for oocyte maturation and early embryonic development, as it facilitates the “maternal-to-zygotic transition (MZT)” by eliminating maternal transcripts and enabling zygotic genome activation (ZGA). However, the physiological role of the poly(A)-specific nuclease 2 (PAN2), a deadenylase that initiates cascade degradation of long-tailed transcripts, remains unknown. Here, we generated oocyte-specific <em>Pan2</em> conditional knockout (cKO) mice to investigate its role. We found that <em>Pan2</em> cKO females exhibit severe female subfertility despite normal oocyte maturation and ovulation, with embryos arresting at the 2-cell stage. PAIso-seq2 and transcriptome sequencing reveal that PAN2 coordinates maternal mRNA deadenylation and decay. Mechanistically, PAN2 recognizes its substrates through a PAN3-PABPC1 bridging complex, and it preferentially targets transcripts whose poly(A) tails lack guanosine (G) but are enriched for uridine (U). PAN2 deficiency causes poly(A) tail dyshomeostasis, leading to global accumulation of maternal mRNAs, impaired zygotic genome activation, and abnormal protein accumulation in 2-cell embryos. Overexpression of these proteins phenocopies developmental defects. Notably, the PAN2-regulated transcriptome is largely non-overlapping with the LC3B-mediated degradation pathway, highlighting the unique and non-redundant role of PAN2 in maternal mRNA clearance. Our study establishes maternal PAN2 as a critical regulator of poly(A) tail homeostasis, ensuring timely maternal mRNA clearance and proper ZGA, highlighting the stage-specific and tail-composition-dependent functions of the deadenylase cascade during the maternal-to-zygotic transition. These findings offer new perspectives on post-transcriptional regulatory mechanisms in early mammalian embryogenesis.</div></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 19","pages":"Pages 5026-5044"},"PeriodicalIF":20.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148890734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fructooligosaccharides alleviate hyperuricemia via the “Ligilactobacillus murinus-Anaerotruncus colihominis” axis","authors":"Wenlong Sun,&nbsp;Yuanyuan Guan,&nbsp;Yaxin Cao,&nbsp;Ling Dong,&nbsp;Yanrong Wang,&nbsp;Zhaosen Fan,&nbsp;Xinhua Song,&nbsp;Chenhong Zhang,&nbsp;Lingru Li,&nbsp;Yanfei Zheng,&nbsp;Qi Wang","doi":"10.1016/j.scib.2026.07.021","DOIUrl":"10.1016/j.scib.2026.07.021","url":null,"abstract":"<div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (256KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span><span><span><p>Schematic diagram of the alleviation of hyperuricemia via the fructooligosaccharide-induced “<em>Ligilactobacillus murinus</em>-<em>Anaerotruncus colihominis</em>” axis.</p></span></span></figure></span></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 19","pages":"Pages 4922-4926"},"PeriodicalIF":20.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148629210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"p-Block metal boosted oxygen electrocatalysis of Fe–N–C for alkaline seawater electrolyte-based zinc-air batteries","authors":"Yuxin Zhang,&nbsp;Yurong Liu,&nbsp;Xue Zhang,&nbsp;Meizhen Chen,&nbsp;Min Chen,&nbsp;Jing Li,&nbsp;Zhitong Wang,&nbsp;Yonghao Xiao,&nbsp;Xiaodong Shi,&nbsp;Zhenye Kang,&nbsp;Zhuoliang Jiang,&nbsp;Lutong Shan,&nbsp;Xinlong Tian,&nbsp;Mingkai Liu,&nbsp;Peng Rao","doi":"10.1016/j.scib.2026.07.056","DOIUrl":"10.1016/j.scib.2026.07.056","url":null,"abstract":"<div><div>Seawater electrolyte-based zinc-air batteries (SZABs) offer advantages such as high theoretical energy density, safety, and environmental friendliness. However, their commercial application is limited by sluggish oxygen reduction reaction (ORR) kinetics and Cl⁻ adsorption-induced corrosion of the catalysts in seawater. Herein, we propose the construction of a typical p–d orbital hybridization structure between p-block and d-block metal atoms, which enables the simultaneous enhancement of ORR kinetics and inhibition of Cl⁻-induced poisoning of the active sites. First, Fe-based p–d orbital hybrid catalysts are screened via theoretical calculations, and FeSn dual single-atom catalysts (FeSn-DSACs) are identified as the optimal choice, attributed to their ideal adsorption free energy profiles for both *OH and Cl⁻. The resultant FeSn-DSACs demonstrate desirable ORR performance in an alkaline seawater. When assembled into SZABs, they deliver a peak power density of 255.6 mW cm⁻² and exhibit stable operation for over 500 h. Theoretical calculations and <em>in-situ</em> characterizations suggest that p–d hybridization in the FeSn-DSACs weakens the strong adsorption energy of traditional Fe sites towards *OH intermediates, while the high electron cloud density of Sn sites <em>in-situ</em> constructs a locally negatively charged interface to inhibit the adsorption and corrosion of Cl⁻, collectively significantly enhancing the seawater ORR catalytic activity and stability.</div></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 19","pages":"Pages 4981-4990"},"PeriodicalIF":20.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148710878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re-entry risk at scale: numerical prediction of large-scale spacecraft reentry disintegration and global governance","authors":"Zhihui Li,&nbsp;Jianping Zhou,&nbsp;Ning Wei","doi":"10.1016/j.scib.2026.08.041","DOIUrl":"10.1016/j.scib.2026.08.041","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 19","pages":"Pages 4897-4901"},"PeriodicalIF":20.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148878927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatially coupled effects of urban vegetation on air pollution and heat islands in coastal cities across the globe","authors":"Kongming Li,&nbsp;Yonglong Lu,&nbsp;Bin Sun,&nbsp;Qi Wang,&nbsp;Yunting Xiong,&nbsp;Zhenjun Zhang,&nbsp;Xudong Jiang,&nbsp;James M. Bullock,&nbsp;Jingjing Yuan","doi":"10.1016/j.scib.2026.08.049","DOIUrl":"10.1016/j.scib.2026.08.049","url":null,"abstract":"<div><div>Urban vegetation is considered an optimal mitigation strategy to combat urban air pollution and heat islands. However, the spatially coupled effects of vegetation landscape morphologies and canopy traits on air pollution and heat islands remain unclear, especially for coastal cities vulnerable to climate change. We investigated the spatial patterns of air pollution intensity (API) and surface urban heat islands (SUHI) in major coastal cities across the globe by utilizing multi-source remote sensing data, and examined the coupled effects of multiple urban vegetation factors (UVFs). We found strong spatial variation in API and SUHI among major coastal cities across the globe, with spatial averages of 0.51 ± 0.18 and 1.15  ± 2.31 ℃, respectively; API was higher in the tropical climate zone than other climate zones (0.53 ± 0.18), while SUHI was the greatest in temperate climate zones (1.48 ± 2.29 ℃). The direction or magnitude of effects of UVFs on API and SUHI varied with climate zones, demonstrating the strong climate dependency. Vegetation landscape morphologies, including fragmentation index (FI), canopy height (TH), and fractional vegetation cover (FVC), have a more direct and positive impact on API and SUHI reduction, compared to canopy traits. Vegetation landscape morphologies exhibited stronger synergistic effects on API and SUHI than vegetation canopy traits, suggesting that the former has great potential for co-mitigation of air pollutants and heat stress; notably, they also showed a strong Lose-lose coupled scenario in regulating API and SUHI, accounting for over 35% of total paired observations. Besides, the tallest canopy height (6.83 ± 1.43 m) occurred in high SUHI and high API spatial clusters. This study provides valuable insights for vegetation landscape optimization to mitigate urban pollution and heat islands.</div></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 19","pages":"Pages 5090-5102"},"PeriodicalIF":20.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148885756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-pressure crystal structure database","authors":"Zhenyu Wang,&nbsp;Qingchang Wang,&nbsp;Honglin Li,&nbsp;Junwen Duan,&nbsp;Heng Ge,&nbsp;Xiaoshan Luo,&nbsp;Pengyue Gao,&nbsp;Wei Zhang,&nbsp;Jian Lv,&nbsp;Yanchao Wang,&nbsp;Yanming Ma","doi":"10.1016/j.scib.2026.08.047","DOIUrl":"10.1016/j.scib.2026.08.047","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 19","pages":"Pages 4907-4911"},"PeriodicalIF":20.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148904544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Landscaping neurodevelopment of attention-deficit hyperactivity disorder","authors":"Ningning Liu,&nbsp;Yin-Shan Wang,&nbsp;Zi-Xuan Zhou,&nbsp;Peng Gao,&nbsp;Chongjing Luo,&nbsp;Xinyi Zhang,&nbsp;Ziqing Zhu,&nbsp;Yuan Gao,&nbsp;Fei Ren,&nbsp;Yan Zhu,&nbsp;Li-Zhen Chen,&nbsp;Haimei Li,&nbsp;Changxi Ju,&nbsp;Ping Wang,&nbsp;Saashi Bedford,&nbsp;Clara Pecci Terroba,&nbsp;Lena Dorfschmidt,&nbsp;Richard A.I. Bethlehem,&nbsp;Ning Yang,&nbsp;Zhu-Qing Gong,&nbsp;Xi-Nian Zuo","doi":"10.1016/j.scib.2026.09.001","DOIUrl":"10.1016/j.scib.2026.09.001","url":null,"abstract":"<div><div>We aim to decipher the neurodevelopmental diversity of attention-deficit hyperactivity disorder (ADHD) using lifespan brain charts within a <em>brainality landscape</em> framework. It first generated age- and sex-referenced centile scores of brain morphology for 270 children with ADHD by revising the worldwide lifespan brain chart (<em>n</em> = 177,701) for 31,894 healthy Chinese samples, including 25,768 scans from the Chinese Brain Health Imaging Consortium (CHART) and 6126 scans from the Chinese Child Brain Development (CCBD) study. Children with ADHD were then classified using partitioning around medoids based on their centile scores as deviations from a developing control reference to identify trait constellations underlying ADHD’s landscape heterogeneity. The <em>brainality landscape</em> identified two neurotypes: children with smaller volume (SVC-ADHD) and children with larger volume (LVC-ADHD), who are not different between sex, imaging site, gestational and maternal age as well as clinical symptom composition. SVC-ADHD children are younger and have lower mean birth weight, and showed neurocognitive impairments and poorer hemispheric differentiation within the default network as well as more gene expressions related to organism developmental processes, and more prenatal risk factors such as maternal passive smoking. In contrast, LVC-ADHD children are older and demonstrated more pronounced behavior and emotional impairments, while their language, somatomotor, and cognitive control networks exhibited poorer hemispheric specialization. Genetic findings were less pronounced in LVC-ADHD and remained exploratory and mainly linked to neurogenesis. Our work charted the brainality of ADHD to reflect distinct developmental profiles with combinations of genetic, prenatal, and later-life influences, implying clinical potential of future precision translation.</div></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 19","pages":"Pages 5058-5072"},"PeriodicalIF":20.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148943803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serine metabolism hijacks radiotherapy-driven antitumor immunity via suppressing STING-dependent DNA sensing","authors":"Xiaochuan Hong,&nbsp;Yuanqin Yang,&nbsp;Lingling Wu,&nbsp;Shuting Xu,&nbsp;Chao Yang,&nbsp;Tong Cui,&nbsp;Qishan Wang,&nbsp;Zhihao Wu,&nbsp;Xueni Yu,&nbsp;Qi Chen,&nbsp;Hanyu Hong,&nbsp;Qianjiang Chen,&nbsp;Dongqing Cao,&nbsp;Zhitao Gu,&nbsp;Liufu Deng,&nbsp;Lu Lu","doi":"10.1016/j.scib.2026.06.032","DOIUrl":"10.1016/j.scib.2026.06.032","url":null,"abstract":"<div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (139KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 19","pages":"Pages 4917-4921"},"PeriodicalIF":20.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148497003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}