Science Bulletin最新文献_第4页

An unconventional topology of betacoronavirus membrane protein drives viral assembly. 冠状病毒膜蛋白的非常规拓扑结构驱动病毒组装。

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2025-06-16 DOI: 10.1016/j.scib.2025.06.012

Rui Lyu, Kaili Li, Lingjiao Xiang, Yingjian Li, Yaotian Liang, Xue Tan, Xiaoya Huang, Yu Chen, Hongyu Deng, Junjie Hu

引用次数: 0

Mapping flood regulation service flow: a beneficiary approach. 防洪服务流程映射：一种受益人方法。

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2025-06-16 DOI: 10.1016/j.scib.2025.06.019

Jiabin Wang, Jian Peng, Pei Xia, Yifan Lin, Shuying Yu, Zihan Xu

引用次数: 0

Proliferative T-regulatory cells as a biomarker for immune checkpoint inhibitor efficacy in nasopharyngeal carcinoma: a new frontier. 增殖t调节细胞作为免疫检查点抑制剂在鼻咽癌疗效的生物标志物：一个新的前沿。

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2025-06-16 DOI: 10.1016/j.scib.2025.06.011

Ashish Dahal, Ravindra Uppaluri, Jonathan D Schoenfeld

引用次数: 0

AI-identified peptides boost jasmonate-mediated natural resistance against citrus Huanglongbing. ai鉴定的肽增强茉莉素介导的柑橘黄龙冰自然抗性。

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2025-06-16 DOI: 10.1016/j.scib.2025.06.018

Zhibo Zhao, Shufeng Du, Daowen Wang, Yong Wang, Zheng Qing Fu

引用次数: 0

The rate of magnetic reconnection in non-steady state. 非稳态下的磁重联速率。

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2025-06-16 DOI: 10.1016/j.scib.2025.06.014

Quanming Lu, Yukang Shu, Cong Chang, San Lu, Rongsheng Wang

引用次数: 0

Injectable self-healing hydrogels loaded with islet-integrated microfiber scaffolds for islet transplantation in diabetes mellitus. 装载胰岛整合微纤维支架的可注射自愈水凝胶用于糖尿病胰岛移植。

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2025-06-16 DOI: 10.1016/j.scib.2025.06.016

Zhikun Huan, Jingbo Li, Xinyue Cao, Minhui Lu, Yunru Yu, Ling Li

{"title":"Injectable self-healing hydrogels loaded with islet-integrated microfiber scaffolds for islet transplantation in diabetes mellitus.","authors":"Zhikun Huan, Jingbo Li, Xinyue Cao, Minhui Lu, Yunru Yu, Ling Li","doi":"10.1016/j.scib.2025.06.016","DOIUrl":"https://doi.org/10.1016/j.scib.2025.06.016","url":null,"abstract":"Current research on islet transplantation is aimed at prolonging the survival time and enhancing the functionality of the transplantation system. Owing to the good biocompatibility of hydrogels and their ability to provide mechanical support and immunological isolation of islet cells, hydrogel encapsulation of islets offers an innovative solution for islet transplantation. In this work, inspired by the extracellular matrix structure of the pancreatic islets, an injectable self-healing hydrogel loaded with islet-integrated microfiber scaffolds was constructed for islet transplantation. The short microfiber was fabricated by introducing a gaseous phase into microfluidic spinning, causing the continuous microfibers to break into short segments due to bubble rupture. These short microfibers provide mechanical support for pancreatic islets and can be integrated into a self-healing matrix to form a vascularized hydrogel through Schiff base bonding of oxidized sodium alginate aldehyde groups with carboxymethyl chitosan amino groups. With the loading of human umbilical vein endothelial cells and vascular endothelial growth factor, this composite is both injectable and provides mechanical support for the grafts, extends islet survival time, and improves islet function. In vivo experiments further confirm that this bioinspired composite system minimizes implantation-associated trauma while promoting neovascularization at the graft site in diabetic rodents, thereby achieving prolonged glycemic control compared to non-vascularized systems. These findings demonstrate that this hierarchically structured multifunctional graft platform has substantial research value and extensive therapeutic potential in the fields of cell therapy and tissue engineering for the treatment of diabetes and related diseases.","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Parvalbumin interneurons are essential for tonotopy strength in the auditory cortex. 小白蛋白中间神经元是听觉皮层张力的重要组成部分。

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2025-06-16 DOI: 10.1016/j.scib.2025.06.020

Xiaojing Tang, Zhikai Zhao, Longhui Li, Jie Tao, Yiheng Chen, Mahiber Polat, Zhiqi Yang, Zhihao Wei, Shanshan Liang, Kuan Zhang, Xiang Liao, Hongbo Jia, Sunny C Li, Xiaowei Chen

{"title":"Parvalbumin interneurons are essential for tonotopy strength in the auditory cortex.","authors":"Xiaojing Tang, Zhikai Zhao, Longhui Li, Jie Tao, Yiheng Chen, Mahiber Polat, Zhiqi Yang, Zhihao Wei, Shanshan Liang, Kuan Zhang, Xiang Liao, Hongbo Jia, Sunny C Li, Xiaowei Chen","doi":"10.1016/j.scib.2025.06.020","DOIUrl":"https://doi.org/10.1016/j.scib.2025.06.020","url":null,"abstract":"Tonotopy, the spatial organization of neurons based on their sound frequency responses, is a fundamental feature of the auditory pathway, extending from the cochlea to the auditory cortex. While excitatory neurons have been considered necessary for tonotopy in the cortex, the role of inhibitory interneurons remains unclear. Using a novel two-channel widefield Ca2+ imaging system, the 2-Channel Alternating exposure wide-Field Explorer (2-CAFE), we simultaneously measured the sound responsiveness of distinct neuron types in awake mice. Combined with two-photon imaging, we observed that GABAergic interneurons followed a similar tonotopic organization to the conventional auditory maps at both mesoscale and single-cell resolutions. Among the major interneuron subtypes-parvalbumin (PV), somatostatin (SST), and vasoactive intestinal peptide (VIP)-PV interneurons demonstrated a critical role in maintaining tonotopy. Inactivation of PV neurons, but not VIP or SST neurons, significantly weakened the tonotopic strength in the auditory cortex. These findings establish PV interneurons as essential components of auditory cortical tonotopy.","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144566917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peak accumulation of soil organic carbon in the early Holocene. 全新世早期土壤有机碳积累高峰。

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2025-06-16 DOI: 10.1016/j.scib.2025.05.046

Juan Li, Shanshan Yang, Pete Smith, Jiayi Li, Xiling Gu, Huangyu Huo, Yuxi Wei, Liqing Zhao, Minghan Yu, Jinzhi Ding

{"title":"Peak accumulation of soil organic carbon in the early Holocene.","authors":"Juan Li, Shanshan Yang, Pete Smith, Jiayi Li, Xiling Gu, Huangyu Huo, Yuxi Wei, Liqing Zhao, Minghan Yu, Jinzhi Ding","doi":"10.1016/j.scib.2025.05.046","DOIUrl":"https://doi.org/10.1016/j.scib.2025.05.046","url":null,"abstract":"Soil holds significant potential to mitigate atmospheric CO2 concentrations through the sequestration of organic carbon, yet its contribution to fluctuations in atmospheric CO2 over the Holocene has been a matter of much speculation. Here we explored analyses of 5190 radiocarbon data and 442,737 content observations of soil organic carbon (SOC) to visualize the global abundance-persistence spectrum of SOC and its depth distribution. We found that the present-day soil carbon pool began to accumulate since the Late Pleistocene and reached its peak accumulation in the early Holocene, approximately 8-10 thousand years ago. High-latitude regions contain significant amounts of ancient carbon, even in shallow soil layers, with maximum sequestration driven by post-glacial vegetation recovery and peatland development, which contributed to reducing CO2 and temperature fluctuations during the early Holocene. However, higher temperatures correspond to suppressed carbon accumulation in the Holocene, implying that ongoing global warming may further deplete soil carbon pools and threaten the sustainability of soil carbon sequestration.","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanoconfinement-mediated water treatment: where to go? 纳米禁锢介导的水处理：何去何从？

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2025-06-16 DOI: 10.1016/j.scib.2025.06.017

Wanyi Fu, Hui Xu, Zhichao Yang, Bingcai Pan

引用次数: 0

Rapid increase in carbon sink from China's urban forests. 中国城市森林碳汇快速增长。

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2025-06-14 DOI: 10.1016/j.scib.2025.06.015

Weixiang Cai, Nianpeng He, Li Xu, Hongbo Guo, Zhenghu Zhou, Ding Wen, Xiaoyong Bai, Guirui Yu

引用次数: 0