Science Bulletin最新文献

{"title":"Understanding mood through facial expressions: opportunities and challenges in depression detection.","authors":"Lei Feng, Nanxi Li, Sagar Jilka, Joseph Firth, Gang Wang","doi":"10.1016/j.scib.2025.09.047","DOIUrl":"https://doi.org/10.1016/j.scib.2025.09.047","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":21.1,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thermodynamic-driven graphene layer control: converging paradigms from self-correcting and edge-feeding growth.","authors":"Yi Cheng, James M Tour","doi":"10.1016/j.scib.2025.09.048","DOIUrl":"https://doi.org/10.1016/j.scib.2025.09.048","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":21.1,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145353389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lactate-driven histone lactylation enhances GDF15 secretion in skeletal muscle under mtDNA mutation-induced mitochondrial stress.","authors":"Yan Lin, Busu Li, Jiayin Wang, Weiyue Si, Xingyu Zhuang, Ying Zhao, Wei Jiang, Wei Wang, Dongdong Wang, Fuchen Liu, Ruonan Duan, Yuying Zhao, Yunfan Yang, Jian-Sheng Kang, Xiaorong Zhang, Linpeng Li, Xingguo Liu, Chuanzhu Yan, Kunqian Ji","doi":"10.1016/j.scib.2025.09.052","DOIUrl":"https://doi.org/10.1016/j.scib.2025.09.052","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":21.1,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145312151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbial CO₂ capture, conversion, and utilization: towards sustainable biomanufacturing.","authors":"Jian Zhang, Yingying Li, Xiulai Chen","doi":"10.1016/j.scib.2025.09.053","DOIUrl":"https://doi.org/10.1016/j.scib.2025.09.053","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":21.1,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145306581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Release of oxygen (oxidized fluids) by growth of ferromanganese garnets and oxygen circulation in subduction zone.","authors":"Shuguang Song, Shiting Ye, Ming Tang, Heidi E Höfer, Mark B Allen, Xiaoli Li","doi":"10.1016/j.scib.2025.09.046","DOIUrl":"https://doi.org/10.1016/j.scib.2025.09.046","url":null,"abstract":"<p><p>Subduction zones are important for oxygen cycling between deep and surficial Earth reservoirs. Highly oxidizing materials from Earth's surface may be transported to the mantle along with the subducting slabs and alter the redox states of the mantle wedge and the 410-660 km transition zone. The circulation of oxygen or oxidizing fluids in subduction zones and how subducted materials influence the deep mantle are poorly constrained. Here we report growth of Fe-Mn garnet from highly oxidized pelagic ferromanganese chert within a high-pressure metamorphic complex in the Qilian Orogen, North West (NW) China. Two types of ferric-iron-rich garnets were identified. Type I is spessartine garnet that has clear compositional zonation of Al₂O₃-FeOt-MnO oscillatory growth. The Fe³⁺/∑Fe ratio in the core is as high as 1.0, but decreases to 0.1 in the outer rim, along with an increase of Fe²⁺ content and a significant decrease in Mn content. Type II is andradite-calderite garnet that contains extremely high Fe³⁺. Our results have two implications: (1) continuous reduction of Mn⁴⁺ (to Mn²⁺) and Fe³⁺ (to Fe²⁺) from the ferromanganese chert as garnet growth must be accompanied by releasing large quantity of oxygen or highly oxidized fluids during prograde high-pressure metamorphism in subduction zones, and (2) Fe³⁺-rich garnets together with hematite in the subducting slab can remain stable over a large pressure range, and provide an alternative interpretation for the high content of Fe³⁺ in the deep mantle. Our results are significant for understanding the oxygen recycling in oceanic cold subduction zones, and the initiation of the Great Oxygen Event (GOE) as well.</p>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":21.1,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Climate teleconnections among the Earth's three poles.","authors":"Anmin Duan, Xin Li, Wenting Hu, Tao Che, Jun Hu, Yuzhuo Peng, Chao Zhang, Die Hu, Yuheng Tang, Zhulei Pan, Qilu Wang, Guoxiong Wu","doi":"10.1016/j.scib.2025.09.045","DOIUrl":"https://doi.org/10.1016/j.scib.2025.09.045","url":null,"abstract":"<p><p>The Arctic, Antarctic, and Tibetan Plateau (TP) are often referred to as Earth's three poles, and they exert outsized influence on the global climate. The three poles have undergone accelerating loss of sea ice, ice shelves, and/or glaciers, accompanied by pronounced warming in the Arctic and TP and region-specific warming in Antarctica. Despite their geographical remoteness, the three poles exhibit evident linkages, yet substantial gaps remain in our understanding of their climate teleconnections. This review summarizes the interactions among Earth's three poles. The three poles are dynamically linked through a hierarchy of pathways. The Arctic-TP interactions are dominated by stationary Rossby-wave trains triggered by sea-ice and snow anomalies and reinforced by land-surface feedback over the plateau. The Arctic-Antarctic coupling relies on ocean heat transport through the Atlantic Meridional Overturning Circulation and on the modulation of tropical Atlantic temperature and the Intertropical Convergence Zone. The Antarctic-TP signals travel via sea-surface temperature anomalies in the Indian Ocean forced by the Antarctic Oscillation, which propagate northward and excite wave trains and transport moisture onto the TP. Closing the remaining knowledge gaps will require coordinated paleoclimate constraints, targeted field campaigns over the Southern Ocean and TP, and next-generation Earth-system models equipped with machine-learning techniques. Such integrative efforts are essential for more reliable projections of compound extremes and for informing adaptation strategies.</p>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":21.1,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145273344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nuclear receptor ESRRA promotes ERα-positive breast cancer through dual action on super enhancers and promoters to regulate gene transcriptional programs.","authors":"Zao-Zao Zheng, Lu Chen, Guo-Sheng Hu, Bing-Ling Peng, Qi-Xuan Huang, An Wang, Chuan Wang, Wen Liu","doi":"10.1016/j.scib.2025.09.044","DOIUrl":"https://doi.org/10.1016/j.scib.2025.09.044","url":null,"abstract":"<p><p>Estrogen-Related Receptor Alpha (ESRRA) is an orphan nuclear receptor that plays a pivotal role in regulating cellular metabolism, mitochondrial biogenesis, and energy homeostasis through transcriptional control. It has been implicated in diverse physiological processes and diseases, including cancer. However, the transcriptional programs governed by ESRRA and the underlying molecular mechanisms remain incompletely understood. Here, we demonstrate that ESRRA serves as a central regulator in orchestrating the transcriptional activation of estrogen receptor α(ERα)-occupied super enhancers (ERSEs) and cognate ERα -target genes. In parallel, ESRRA represses the expression of cytosolic RNA sensors RIG1 and MDA5, thereby attenuating type I interferon (IFN) signaling and type I IFN-stimulated genes. In terms of mechanism, ESRRA is recruited to ERSEs together with ERα in response to estrogen and their binding to ERSEs occurs in a mutually dependent manner. In contrast, ESRRA directly binds to the promoter regions of RIG1 and MDA5 to suppress their expression. Consistent with these findings, pharmacological inhibition of ESRRA using its inverse agonist XCT790 suppressed estrogen/ERα-induced gene transcription while enhancing type I IFN pathway and antitumor immunity, thereby restraining ERα-positive breast cancer cell growth both in vitro and in vivo. Combination treatment with XCT790 and endocrine therapies, including the ERα antagonist Tamoxifen or degrader Fulvestrant, produced synergistic antitumor effects. Furthermore, co-treatment with XCT790 and tamoxifen re-sensitized Tamoxifen-resistant ERα-positive breast cancer cells to Tamoxifen treatment. In addition, XCT790 treatment augmented the therapeutic efficacy of chemotherapeutic agents such as Doxorubicin in suppressing ERα-positive breast cancer cell growth both in vitro and in vivo. In summary, our findings reveal that ESRRA is a pivotal regulator of ERSEs and estrogen/ERα-target gene activation, as well as the type I IFN signaling pathway, highlighting its potential as a promising therapeutic target in ERα-positive breast cancer in the clinic.</p>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":21.1,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145327974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to \"comments on 'Methodological appraisal of the study on antenatal depression in China' \".","authors":"Chen Zhang, Chenchi Duan, Han Liu, Hualin Xu, Cheng Li, Jianxia Fan, Hong Li, Xiangjuan Li, Yi Guo, Yeping Wang, Xiufeng Li, Jing Li, Ting Zhang, Yiping You, Hongmei Li, Shuangqi Yang, Xiaoling Tao, Yajuan Xu, Haihong Lao, Ming Wen, Yan Zhou, Junying Wang, Yuhua Chen, Diyun Meng, Jingli Zhai, Youchun Ye, Qinwen Zhong, Xiuping Yang, Jing Zhang, Xifeng Wu, Wei Chen, Cindy-Lee Dennis, Ben Willem J Mol, Dan Zhang, Hefeng Huang, Yanting Wu","doi":"10.1016/j.scib.2025.09.049","DOIUrl":"https://doi.org/10.1016/j.scib.2025.09.049","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":21.1,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145290598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interfacial phosphate ions dehydration for advanced phosphate removal and recovery.","authors":"Lufa Hu, Guangming Zhan, Yancai Yao, Long Zhao, Jie Dai, Yan Zhang, Bing Zhou, Peng Li, Hao Li, Lizhi Zhang","doi":"10.1016/j.scib.2025.09.040","DOIUrl":"https://doi.org/10.1016/j.scib.2025.09.040","url":null,"abstract":"<p><p>Phosphate removal and recovery by adsorption is vital in addressing the phosphorus-induced water eutrophication and mitigating the depletion of phosphorus resources. However, the formation of hydrated phosphate clusters serves to impede the mass transfer of phosphate from water to the adsorbent. Herein, we demonstrated that interfacial phosphate ions dehydration, by regulating the interfacial hydrogen bonding between water molecules and the surface polar groups of malonamide-modified La(OH)₃ (MA-La(OH)₃), can deliver superior phosphate removal and recovery. The malonamide carbonyl and amino groups weakened the phosphate ions hydration layer via hydrogen bonding interactions with hydrated H₂O (C=O···H and NH···O), thereby enhancing the phosphate ions charge density to promote their migration and coordination with La sites. Impressively, MA-La(OH)₃ exhibited an excellent phosphate removal rate of 99.0% with a high adsorption capacity of 175.4 mg P g^-1, far surpassing La(OH)₃ (79.0% and 112.4 mg P g^-1). The adsorbed phosphate was concentrated to 429.5 mg L^-1 into the residual alkaline solution from MA-La(OH)₃ synthesis and further converted to struvite, reducing the total removal cost by 17.5%. This study offers a proof-of-concept strategy for advanced phosphate removal and recovery, and highlights the importance of interfacial phosphate ions dehydration in enhancing mass transfer and surface adsorption.</p>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":21.1,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145249174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights into black carbon-activated manganese catalysis in atmospheric sulfate production.","authors":"Ziyan Guo, Pengxiang Qiu, Huan Song, Can Ye, Yaning Du, Keding Lu","doi":"10.1016/j.scib.2025.09.041","DOIUrl":"https://doi.org/10.1016/j.scib.2025.09.041","url":null,"abstract":"<p><p>The mechanisms that produce atmospheric sulfate, a critical PM_2.5 constituent, must be elucidated to inform air quality interventions. Current evidence indicates that manganese-catalyzed heterogeneous SO₂ oxidation is a dominant sulfate source. We demonstrate that black carbon (BC) critically enhances this process through interfacial electronic interactions with HSO₃^-/SO₃^2- species, reducing SO₂ oxidation barriers while increasing reactive oxygen species (ROS) generation (¹O₂, ·O₂^-, and ·OH). Unique sulfur isotopic signatures measured in BC-Mn²⁺/O₂ systems confirm a novel oxidation pathway in which BC facilitates electron transfer during O₂-activated SO₂ conversion. Multiphase modeling revealed that under typical haze conditions, BC-mediated catalysis produces sulfate at higher rates than traditional Mn-only pathways. The synergistic BC-Mn system enables continuous redox cycling via O₂ activation, establishing BC as an active electronic modulator rather than a passive substrate in sulfate formation. These findings redefine the role of BC in atmospheric chemistry, offering a molecular basis for targeted sulfate aerosol control.</p>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":21.1,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145249124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}