Science Bulletin最新文献_第5页

Neddylation E2 enzyme UBE2M inhibits inflammatory lung tumor microenvironment by blocking the cGAS-STING signal upon KrasG12D activation 类泛素化E2酶UBE2M通过阻断KrasG12D激活时的cGAS-STING信号抑制炎性肺肿瘤微环境。

IF 20.7 1区综合性期刊

Science Bulletin Pub Date : 2026-09-30 Epub Date: 2026-08-24 DOI: 10.1016/j.scib.2026.08.050

Yawen Zheng, Cantong Chen, Xufan Li, Zhouyang Li, Hua Li, Mingjia Tan, Danyi Zhai, Fengwu Zhang, Wenjing Lu, Zhihua Chen, Yongchao Zhao, Pengyuan Liu, Yan Lu, Xiufang Xiong, Yi Sun

{"title":"Neddylation E2 enzyme UBE2M inhibits inflammatory lung tumor microenvironment by blocking the cGAS-STING signal upon KrasG12D activation","authors":"Yawen Zheng, Cantong Chen, Xufan Li, Zhouyang Li, Hua Li, Mingjia Tan, Danyi Zhai, Fengwu Zhang, Wenjing Lu, Zhihua Chen, Yongchao Zhao, Pengyuan Liu, Yan Lu, Xiufang Xiong, Yi Sun","doi":"10.1016/j.scib.2026.08.050","DOIUrl":"10.1016/j.scib.2026.08.050","url":null,"abstract":"<div><div>UBE2M, also known as UBC12, is one of two neddylation conjugation enzymes. The <em>in vitro</em> cell culture work showed that UBE2M is essential for the growth and survival of cancer cells, but its <em>in vivo</em> role in tumorigenesis, particularly in the tumor microenvironment (TME), remains elusive. Here, we report that in a well-established <em>Kras<sup>G12D</sup></em> lung tumor mouse model, <em>Ube2m</em> deletion caused an inflammatory TME, severe lung edema, and early death. Mechanistically, while <em>Kras</em><sup><em>G12D</em></sup> activates MAPK and mTORC1 signals for proliferation, <em>Ube2m</em> deletion increases mitochondrial MOMP/mPTP and inhibits Parkin neddylation and activity, leading to compromised mitophagy. The combination of <em>Kras<sup>G12D</sup></em> activation and <em>Ube2m</em> deletion caused cytoplasmic release of damaged mitochondrial DNA to activate the cGAS-STING-NF-κB pathway, followed by inflammatory cytokine secretion, immune cell infiltration, and inflammatory TME. This process is largely blocked by the STING antagonist H-151, indicating a causal role of the cGAS-STING axis. In human lung cancer with <em>KRAS</em> mutations, low UBE2M expression is correlated with high infiltrations of immune cells, demonstrating its relevance to human disease. Our study unexpectedly showed a paracrine role of Ube2m in the prevention of TME upon <em>Kras<sup>G12D</sup></em> activation in the lung.</div></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 18","pages":"Pages 4742-4761"},"PeriodicalIF":20.7,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148904513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exceptional everywhere: from exceptional points to exceptional bands 卓越无处不在：从卓越的点到卓越的乐队。

IF 20.7 1区综合性期刊

Science Bulletin Pub Date : 2026-09-30 Epub Date: 2026-08-19 DOI: 10.1016/j.scib.2026.08.037

Kun Ding

引用次数: 0

Regulated external lithium supply enables high-energy sulfurized polyacrylonitrile-graphite fiber batteries 可调节的外部锂供应使高能硫化聚丙烯腈-石墨纤维电池成为可能。

IF 20.7 1区综合性期刊

Science Bulletin Pub Date : 2026-09-30 Epub Date: 2026-08-13 DOI: 10.1016/j.scib.2026.08.024

Tianrui Li, Chuanfa Li, Qian Ye, Yi Jiang, Longmei Ma, Jiaqi Wang, Yiqing Cheng, Kun Zhang, Jiahe Qu, Yingfan Chang, Shiqi Sun, Siwei Cao, Haiyang Cheng, Meng Liao, Peining Chen, Jue Deng, Chen Zhao, Huisheng Peng, Bingjie Wang

{"title":"Regulated external lithium supply enables high-energy sulfurized polyacrylonitrile-graphite fiber batteries","authors":"Tianrui Li, Chuanfa Li, Qian Ye, Yi Jiang, Longmei Ma, Jiaqi Wang, Yiqing Cheng, Kun Zhang, Jiahe Qu, Yingfan Chang, Shiqi Sun, Siwei Cao, Haiyang Cheng, Meng Liao, Peining Chen, Jue Deng, Chen Zhao, Huisheng Peng, Bingjie Wang","doi":"10.1016/j.scib.2026.08.024","DOIUrl":"10.1016/j.scib.2026.08.024","url":null,"abstract":"<div><div>Fiber batteries employing sulfurized polyacrylonitrile (SPAN) redox chemistry address the critical limitations of conventional layered oxide cathodes by offering high theoretical energy density, low cost, and environmental friendliness. However, the complete absence of lithium in the system, coupled with the significant safety concerns associated with lithium metal anodes, makes the development of lithium-SPAN fiber batteries (LSFBs) highly challenging. Herein, by exploiting the inherent twistability of fiber electrodes, we incorporate a lightweight, lithium-infiltrated aramid fiber containing a precisely controlled amount of lithium between the fiber electrodes. This strategy successfully introduces active lithium into the SPAN-graphite fiber system, enabling, for the first time, the efficient and safe operation of LSFBs. The multistrand fiber cell configuration, featuring three independent tabs, enables a sequential activation protocol (SAP) that lithiates the SPAN cathode and promotes the pre-formation of the solid electrolyte interphase (SEI) and cathode electrolyte interphase (CEI) before normal full-cell operation. Consequently, the resulting LSFB full cell, with a low negative-to-positive capacity (N/P) ratio of 1.08, achieves a high initial coulombic efficiency (ICE) of 98.82% and a high specific capacity of 673.2 mAh g<sup>−1</sup>, corresponding to an energy density of 132.2 Wh kg<sup>−1</sup>. This study represents the first realization of a high-energy, dendrite-free SPAN-graphite fiber battery, paving the way for the development of safe, stable, and flexible energy storage systems.</div></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 18","pages":"Pages 4684-4693"},"PeriodicalIF":20.7,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148823503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proteomic characterization of feather decorations and extinct buffalo glue during early Iron Age China 铁器时代早期中国羽毛装饰和已灭绝水牛胶的蛋白质组学特征。

IF 20.7 1区综合性期刊

Science Bulletin Pub Date : 2026-09-30 Epub Date: 2026-04-17 DOI: 10.1016/j.scib.2026.04.036

Binjie Qi, Zhiguo Zhang, Jiajun Wang, Zhipeng Li, Yuling He, Shishan Niu, Xiaomeng Li, Huiyun Rao, Yimin Yang

引用次数: 0

Pathway enrichment analysis of distinct regions of the Iceman’s stomach highlights heterogeneity of protein enrichment profiles 对冰人胃不同区域的途径富集分析强调了蛋白质富集谱的异质性。

IF 20.7 1区综合性期刊

Science Bulletin Pub Date : 2026-09-30 Epub Date: 2026-04-16 DOI: 10.1016/j.scib.2026.04.038

Zenan Wu, Dan Ju, Tianxiang Liu, Huiyun Rao, Qiaomei Fu

引用次数: 0

A liquid-electrode ultra-stretchable monolithic illuminating fiber 一种液体电极超伸缩单片照明光纤。

IF 20.7 1区综合性期刊

Science Bulletin Pub Date : 2026-09-30 Epub Date: 2026-07-06 DOI: 10.1016/j.scib.2026.07.007

Zhangcheng Li, Can Wang, Zhi Liang, Zerui Liu, Zhangao Wang, Renzi Gong, Kangrui Ji, Shengyin Wang, Jiawen Tian, Chong Hou

{"title":"A liquid-electrode ultra-stretchable monolithic illuminating fiber","authors":"Zhangcheng Li, Can Wang, Zhi Liang, Zerui Liu, Zhangao Wang, Renzi Gong, Kangrui Ji, Shengyin Wang, Jiawen Tian, Chong Hou","doi":"10.1016/j.scib.2026.07.007","DOIUrl":"10.1016/j.scib.2026.07.007","url":null,"abstract":"<div><div>Fiber-based light-emitting devices hold promise for next-generation wearable electronics and human-machine interfaces. However, optoelectronic stability under extreme deformation remains challenging due to mechanical incompatibility at heterogeneous solid-solid interfaces and the difficulty of reconciling conflicting functionalities within fiber electrodes. Here, a liquid-electrode ultra-stretchable monolithic illuminating (LUMI) fiber is presented to address these interfacial limitations. Fabricated via scalable thermal drawing, the LUMI fiber consists of a central liquid metal core and symmetric ionic liquid channels embedded in a unified thermoplastic elastomer matrix. This architecture forms adaptive liquid-solid interfaces, ensuring robust electrical contact and maintaining uniform radial electric fields during dynamic deformation. As a result, the LUMI fiber exhibits excellent omnidirectional luminescence uniformity, sustaining up to 500% tensile strain while preserving stable luminance over 15,000 stretching cycles. Its versatility is further demonstrated by seamless integration into complex textile patterns and adaptability to dynamic, irregular surfaces. Overall, this work provides a comprehensive strategy for developing durable, scalable, and high-performance interactive fibers, advancing the frontiers of stretchable displays and electronic skins.</div></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 18","pages":"Pages 4714-4722"},"PeriodicalIF":20.7,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148534798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inhalable HUCMSC-Lipo biomimetic formulation inhibits fibroblast activation in mouse and non-human primate pulmonary fibrosis models 可吸入的HUCMSC-Lipo仿生制剂抑制小鼠和非人灵长类动物肺纤维化模型的成纤维细胞激活。

IF 20.7 1区综合性期刊

Science Bulletin Pub Date : 2026-09-30 Epub Date: 2026-08-04 DOI: 10.1016/j.scib.2026.08.013

Fangyu Zhao, Yige Sun, Haoran Wang, Dayong Hou, Rui Zhang, Wenjing Xia, Yongchen Zhang, Luyao Li, Xueqi Zhao, Kaiqi Wang, Wenwen Pan, Jiannan Wang, Kai Wang, Lili Yang, Wei Chen, Xin Li, Chunyang Nong, Huiying Lu, Yi Zhang, Zhaoyang Zhang, Xilin Sun

{"title":"Inhalable HUCMSC-Lipo biomimetic formulation inhibits fibroblast activation in mouse and non-human primate pulmonary fibrosis models","authors":"Fangyu Zhao, Yige Sun, Haoran Wang, Dayong Hou, Rui Zhang, Wenjing Xia, Yongchen Zhang, Luyao Li, Xueqi Zhao, Kaiqi Wang, Wenwen Pan, Jiannan Wang, Kai Wang, Lili Yang, Wei Chen, Xin Li, Chunyang Nong, Huiying Lu, Yi Zhang, Zhaoyang Zhang, Xilin Sun","doi":"10.1016/j.scib.2026.08.013","DOIUrl":"10.1016/j.scib.2026.08.013","url":null,"abstract":"<div><div>Pulmonary fibrosis (PF) is a progressive and fatal lung disorder driven by abnormal fibroblast activation and excessive extracellular matrix (ECM) deposition, leading to structural and functional decline. Existing therapies can slow progression but fail to interrupt fibrotic remodeling. Here, we engineered HUCMSC-Lipo, an inhalable biomimetic formulation fusing human umbilical cord mesenchymal stem cell (HUCMSC) membranes with artificial phospholipids, with formulation parameters systematically optimized using a Bayesian optimization (BO) framework to ensure structural stability and nebulization compatibility. HUCMSC-Lipo maintained membrane functionality and structural integrity for effective nebulized delivery. We successfully established a non-human primate (NHP) PF model and innovatively developed a multidimensional evaluation framework. Utilizing a range of methods, including but not limited to positron emission tomography/computed tomography (PET/CT) molecular imaging with radiolabeled fibroblast activation protein (FAP) inhibitors, we confirmed that HUCMSC-Lipo suppressed fibrotic progression and restored pulmonary function by targeting the regulation of fibroblast activation. Mechanistically, THY-1 enrichment in HUCMSC-Lipo bound integrin receptors to block the FAK/PI3K signaling cascade and restore fibroblast mechanosensitivity, fundamentally turning off the pathological activation “switch” in fibroblasts. Our work presents an inhalable biomimetic formulation that combines therapeutic efficacy with synthetic accessibility, offering a mechanism-targeted approach to PF treatment with strong clinical translatability.</div></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 18","pages":"Pages 4694-4713"},"PeriodicalIF":20.7,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148838864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

41Ca exposure dating of glacial moraines 冰川冰碛的ca暴露年代测定。

IF 20.7 1区综合性期刊

Science Bulletin Pub Date : 2026-09-30 Epub Date: 2026-03-24 DOI: 10.1016/j.scib.2026.03.052

Wei-Wei Sun, Guodong Ming, Guo-Min Yang, Hui-Min Zhu, Tian Xia, Ye Yang, Fang Huang, Wei Jiang, Zheng-Tian Lu

引用次数: 0

A potent TGF-β heterodimer orchestrates germ cell homeostasis in fish 一种有效的TGF-β异源二聚体协调鱼类生殖细胞的稳态。

IF 20.7 1区综合性期刊

Science Bulletin Pub Date : 2026-09-30 Epub Date: 2026-06-10 DOI: 10.1016/j.scib.2026.06.025

Ming-Tao Wang, Chun Miao, Sheng Yang, Zhi Li, Meng-Di Zhu, Jie He, Miao Ding, Si-Wei Wu, Yang Zhang, Shun Li, Meng Lu, Peng Yu, Xiao-Juan Zhang, Yang Wang, Zhong-Wei Wang, Li Zhou, Jian-Fang Gui, Xi-Yin Li

引用次数: 0

Flexible radio-frequency carbon nanotube transistors operating in the sub-THz regime 在次太赫兹波段工作的柔性射频碳纳米管晶体管。

IF 20.7 1区综合性期刊

Science Bulletin Pub Date : 2026-09-30 Epub Date: 2026-08-02 DOI: 10.1016/j.scib.2026.08.008

Shuang Qian, Feifei Lin, Qianrui Zhou, Shujuan Liu, Weiwei Zhao, Qiang Zhao

引用次数: 0