Science Bulletin最新文献

{"title":"Tunable siloxane-induced amphiphilic interphase for high-performance gel polymer-based sodium metal batteries.","authors":"Jialin Lin, Weiping Li, Pei Huang, Suting Weng, Tuoya Naren, Chengzuo Gong, Chaoping Liang, Weijie Li, Yuejiao Chen, Libao Chen, Chunxiao Zhang, Xuefeng Wang, Weifeng Wei","doi":"10.1016/j.scib.2024.11.011","DOIUrl":"https://doi.org/10.1016/j.scib.2024.11.011","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142680492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SLC40A1⁺ macrophages contribute to the immunosuppressive tumor microenvironment in EGFR-mutated lung cancer.","authors":"Xinyu Song, Zongjuan Li, Xuanhe Wang, He Du, Yijun Jia, Shen Chen, Anwen Xiong, Wei Li, Xuefei Li, Lei Cheng, Chao Zhao, Lei Wang, Guanghui Gao, Xiaoxia Chen, Chunyan Wu, Zhikai Zhao, Shengxiang Ren, Caicun Zhou, Fengying Wu","doi":"10.1016/j.scib.2024.11.012","DOIUrl":"https://doi.org/10.1016/j.scib.2024.11.012","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"China TCM Cardio Bank (CTC Bank): a high-quality, large-sample and real-world research database.","authors":"Yiwen Li, Yanfei Liu, Mengmeng Zhu, Wenting Wang, Keji Chen, Luqi Huang, Fengqin Xu, Yue Liu","doi":"10.1016/j.scib.2024.11.013","DOIUrl":"https://doi.org/10.1016/j.scib.2024.11.013","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142680489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reconstructing fossil insect communities and palaeoclimates for the Middle Jurassic Yanliao Biota in the Daohugou area of China.","authors":"Liang Chen, Lifang Xiao, Shilong Guo, Nan Yang, Conrad C Labandeira, Chungkun Shih, Chaofan Shi, Dong Ren","doi":"10.1016/j.scib.2024.11.010","DOIUrl":"https://doi.org/10.1016/j.scib.2024.11.010","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142754576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Community prevention and standardized clinical treatment jointly improve cancer outcome: Real-world evidence from an esophageal cancer patient cohort study.","authors":"Ji Ke, Fangfang Liu, Wei Yang, Ruiping Xu, Lei Chen, Wenlei Yang, Yu He, Zhen Liu, Bolin Hou, Liqun Zhang, Miaoping Lin, Lixin Zhang, Fan Zhang, Fen Cai, Huawen Xu, Mengfei Liu, Ying Liu, Yaqi Pan, Zhonghu He, Yang Ke","doi":"10.1016/j.scib.2024.11.005","DOIUrl":"https://doi.org/10.1016/j.scib.2024.11.005","url":null,"abstract":"<p><p>Extensive efforts have been put into reducing the heavy burden of esophageal squamous cell carcinoma (ESCC) in China. However, the joint impact of prevention and treatment on the long-term overall survival (OS) of ESCC patients remains largely unknown. We consecutively recruited 13,255 ESCC patients from two Chinese centers: the Northern center, located in a high-risk area with abundant screening programs; and the Southern center, situated in a non-high-risk area with improved clinical practices. Inter-center comparison, longitudinal intra-center comparison, and a simulation analysis were conducted to investigate the influence of tumor downstaging and high-quality clinical treatment on OS. During a follow-up period of 12.52 years, the Northern center exhibited higher median survival than the Southern center (6.22 vs. 3.15 years; HR_adjusted = 0.73, 95% CI: 0.69-0.77). Mediation analysis demonstrated that its OS advantage was largely (77.7%) attributed to earlier TNM stage (stage 0-II: 51.3% vs. 24.6%). In temporal analyses, patient survival in the Southern center gradually improved (median survival during 2015-2018 vs. 2009-2014: 3.58 vs. 2.93 years; HR_adjusted = 0.86, 95% CI: 0.79-0.94), coinciding with the progress of treatment-related indices (completeness of TNM staging in discharge diagnosis [from 53.7% to 99.6%], adoption of minimally invasive esophagectomy [from 0.0% to 51.1%] and right thoracic esophagectomy [from 12.4% to 86.4%], etc.). Simulation analysis further demonstrated that integrating both downstaging and high-quality treatment would lead to the best survival. Tumor downstaging and high-quality clinical treatment have a joint impact on ESCC patient survival. Establishing a comprehensive strategy that integrates cancer prevention with optimal clinical treatment is crucial for alleviating the ESCC burden.</p>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shifting agricultural land use and its unintended water consumption in the North China Plain.","authors":"Liang Dong, Di Long, Caijin Zhang, Yingjie Cui, Yanhong Cui, Yiming Wang, Luoqi Li, Zhongkun Hong, Ling Yao, Jinling Quan, Liangliang Bai, Hao Wang, Bridget R Scanlon","doi":"10.1016/j.scib.2024.11.009","DOIUrl":"https://doi.org/10.1016/j.scib.2024.11.009","url":null,"abstract":"<p><p>Agricultural land use (ALU) critically influences food production and water resource allocation. This study examines the dynamics of ALU in the North China Plain (NCP), a region characterized by intensive agriculture and severe groundwater over-exploitation, focusing on the multidimensional drivers and their implications for water resource management. By employing an elaborate classification scheme based on satellite imagery and extensive first-hand field data, we identified significant shifts in crop patterns. From 2013 to 2017, there was a notable transition from double crops (primarily wheat-maize) to single crops (primarily maize), covering 4600 km² and accounting for 42% of single crops in 2013. From 2017 to 2022, there was a shift from single crops to economic forests, encompassing 3600 km² and 22% of economic forests in 2017, including orchards, timber trees, and shelter forest belts. These shifts resulted in an 11% decrease in grain acreage (6800 km²) but an 11% increase in crop water consumption (6.3 km³) during 2013-2022. Notably, water consumption by economic forests increased by 126% (9.4 km³) during this period. This study highlights the critical need to balance competing demands for food and water security, providing valuable insights applicable to other agriculturally intensive regions worldwide.</p>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142643329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adoption and adaption: the rise of Pb-Ba glass underlines the impact of soda glass along the pre-Silk Road.","authors":"Siwen Xu, Yunbing Luo, Zhiheng Li, Yemao Hou, Nian Liu, Yimin Yang","doi":"10.1016/j.scib.2024.11.007","DOIUrl":"https://doi.org/10.1016/j.scib.2024.11.007","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142692389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epigenetics in high-altitude adaptation and disease.","authors":"Siyang Wang, Quan Hong, Ying Zheng, Shuwei Duan, Guangyan Cai, Xiangmei Chen","doi":"10.1016/j.scib.2024.11.008","DOIUrl":"https://doi.org/10.1016/j.scib.2024.11.008","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142674770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current status and future directions of medical device research.","authors":"Chenxi He, Hongguang Wang","doi":"10.1016/j.scib.2024.11.006","DOIUrl":"https://doi.org/10.1016/j.scib.2024.11.006","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142674762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Restoring sweat gland function in mice using regenerative sweat gland cells derived from chemically reprogrammed human epidermal keratinocytes.","authors":"Jiangbing Xiang, Huating Chen, Hongliang Zhang, Lu Wu, Yan Li, Shuaifei Ji, Wei Pi, Shaoyuan Cui, Lei Dong, Xiaobing Fu, Xiaoyan Sun","doi":"10.1016/j.scib.2024.11.003","DOIUrl":"https://doi.org/10.1016/j.scib.2024.11.003","url":null,"abstract":"<p><p>The regeneration of sweat glands (SwGs) plays a pivotal role in the functional recovery of extensive skin wounds. Recent research has illuminated the possibility of reprogramming human epidermal keratinocytes (HEKs) into induced SwG cells through the ectopic expression of ectodysplasin A. However, the clinical application of this genetic manipulation approach is inherently limited. In this study, we present findings demonstrating that a combination of six compounds can effectively and speedily reprogram HEKs in culture into fully functional SwG cells. These chemically induced SwG-like cells (ciSGCs) closely resemble the morphology, phenotypes, and functional properties of human primary SwG ductal cells. Furthermore, ciSGCs can be stimulated to differentiate into mature SwG cell types in vitro. In a 3D culture system, they can also generate SwG organoids that exhibit structural and biological features akin to native SwGs. Upon transplantation into scalded mouse paw skin, ciSGCs significantly expedited cutaneous wound healing and completely restored the structural and functional aspects of the SwGs. In conclusion, the small molecule cocktail-directed SwG reprogramming offers a non-transgenic and controllable strategy for producing high-quality, clinical-grade SwG cells, showing immense potential for the treatment of burn patients.</p>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142643678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}