Science Bulletin最新文献_第5页

Computationally-assisted wearable system for continuous cortisol monitoring. 计算辅助可穿戴系统持续监测皮质醇。

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2025-04-17 DOI: 10.1016/j.scib.2025.03.060

Ying Liu, Xiaoyu Su, Peidi Fan, Xin Liu, Yuxiang Pan, Jianfeng Ping

{"title":"Computationally-assisted wearable system for continuous cortisol monitoring.","authors":"Ying Liu, Xiaoyu Su, Peidi Fan, Xin Liu, Yuxiang Pan, Jianfeng Ping","doi":"10.1016/j.scib.2025.03.060","DOIUrl":"https://doi.org/10.1016/j.scib.2025.03.060","url":null,"abstract":"Continuous cortisol monitoring (CCM) is essential for stress management, providing physiological insights into psychology and physical health. However, promising platform for CCM urges the design of effective biorecognition moieties and the skin integration of sophisticated functions. Herein, we present a computationally-assisted wearable system for CCM (CWSCCM) that leverages cutting-edge interdisciplinary technologies of in-situ regenerative molecularly imprinted polymers (MIP), signal amplifier organic electrochemical transistor (OECT), iontophoresis-based sweat induction, and microfluidic sweat sampling. The highly integrated system incorporated with OECT biosensor enables in-situ MIP regeneration, and offers continuous approach for cortisol monitoring, with an ultra-low limit of detection of 0.36 nmol/L. We validated the capability of the CWSCCM for long-term cortisol circadian rhythm monitoring in human participants, which shows superior sensitivity, selectivity, and continuous monitoring capabilities. In conclusion, we demonstrated how computational chemistry and OECT technology can extend the capabilities of current wearable CCM, which could potentially advance closed-loop therapeutics applications.","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Customized engineering of large extrachromosomal DNA: a novel tool for revealing the origins of tumorigenesis. 大染色体外DNA的定制工程：揭示肿瘤发生起源的新工具。

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2025-04-16 DOI: 10.1016/j.scib.2025.04.033

Yongye Huang, Shihong Qi, Min Wu

引用次数: 0

Steering CO2 electroreduction to hydrocarbons over 2D thiol-based conductive metal-organic framework 在二维硫醇基导电金属有机框架上，将二氧化碳电还原为碳氢化合物。

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2025-04-15 DOI: 10.1016/j.scib.2025.01.033

Qiu-Jin Wu , Duan-Hui Si , Yu-Liang Dong , Qian Chen , Li-Li Han , Rong Cao , Yuan-Biao Huang

{"title":"Steering CO2 electroreduction to hydrocarbons over 2D thiol-based conductive metal-organic framework","authors":"Qiu-Jin Wu , Duan-Hui Si , Yu-Liang Dong , Qian Chen , Li-Li Han , Rong Cao , Yuan-Biao Huang","doi":"10.1016/j.scib.2025.01.033","DOIUrl":"10.1016/j.scib.2025.01.033","url":null,"abstract":"<div><div>Almost all of CuxS compounds only produce the simple two-electron transferred products CO and HCOOH but it remains a large challenge to obtain the multiple-electron transferred hydrocarbon products in electrocatalytic CO2 reduction reaction (CO2RR). Moreover, identifying the distinct contributions of S atoms to catalysis, particularly for catalytic activity and product selectivity in electrocatalytic CO2RR, remains a challenging task. Herein, we introduce a model catalyst based on a conductive two-dimensional metal-organic framework with defined Cu-S4 active sites, named Cu3(THT)2 (THT = 2,3,6,7,10,11-hexathiotriphenylene) for CO2RR. Unlike the precursor catalyst Cu3(HITP)2 with Cu-N4 motifs that predominantly produce common two-electron transferred product CO (40% selectivity), Cu3(THT)2 shifts the primary product to deep reduction product CH4. At −1.4 V versus the reversible hydrogen electrode (RHE), Cu3(THT)2 achieves a Faradaic efficiency of 63.5% for CH4 and the current density reaches a high value of −298.3 mA cm−2. Theoretical studies indicate that the electron-rich Cu-S4 sites stabilize and activate the key intermediate *CO more effectively than Cu-N4 sites. Furthermore, S atoms can accept electrons and form weak S···O interactions with *CO, providing additional stabilization for *CO. This study is the first to show that non-metallic S centers around catalytic metal sites can significantly enhance and tune product selectivity in CO2RR.</div></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"70 7","pages":"Pages 1107-1117"},"PeriodicalIF":18.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How many trees are there in China? 中国有多少棵树？

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2025-04-15 DOI: 10.1016/j.scib.2025.02.001

Kai Cheng , Haitao Yang , Yuling Chen , Zekun Yang , Yu Ren , Yixuan Zhang , Danyang Lin , Weiyan Liu , Guoran Huang , Jiachen Xu , Mengxi Chen , Zhiyong Qi , Guangcai Xu , Shengli Tao , Hongcan Guan , Qin Ma , Huawei Wan , Tianyu Hu , Yanjun Su , Zhiheng Wang , Qinghua Guo

引用次数: 0

Associations of body mass index trajectories, weight change with mortality among the oldest old: do they differ from general older adults? 老年人体重指数轨迹、体重变化与死亡率的关系：它们与一般老年人不同吗？

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2025-04-15 DOI: 10.1016/j.scib.2025.01.040

Li Qi , Chen Chen , Jinhui Zhou , Sixin Liu , Jun Wang , Yuan Wei , Wenhui Shi , Yang Li , Tao Zhang , Yuebin Lv , Xiaoming Shi

引用次数: 0

Tumor cell-derived N-acetyl-aspartyl-glutamate reshapes the tumor microenvironment to facilitate breast cancer metastasis 肿瘤细胞来源的n -乙酰-天冬氨酸重塑肿瘤微环境，促进乳腺癌转移。

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2025-04-15 DOI: 10.1016/j.scib.2024.12.039

Jie Xia , Lixing Zhang , Wucheng Zhu , Juchuanli Tu , Xilei Peng , Qiaodan Deng , Siqin Li , Xueyan He , Haonan Dong , Cuicui Liu , Xian Chen , Jiahui Xu , Wei Ma , Yi Xiao , Wen Liu , Guohong Hu , Yi-Zhou Jiang , Ceshi Chen , Xiu-Wu Bian , Zhi-Ming Shao , Suling Liu

{"title":"Tumor cell-derived N-acetyl-aspartyl-glutamate reshapes the tumor microenvironment to facilitate breast cancer metastasis","authors":"Jie Xia , Lixing Zhang , Wucheng Zhu , Juchuanli Tu , Xilei Peng , Qiaodan Deng , Siqin Li , Xueyan He , Haonan Dong , Cuicui Liu , Xian Chen , Jiahui Xu , Wei Ma , Yi Xiao , Wen Liu , Guohong Hu , Yi-Zhou Jiang , Ceshi Chen , Xiu-Wu Bian , Zhi-Ming Shao , Suling Liu","doi":"10.1016/j.scib.2024.12.039","DOIUrl":"10.1016/j.scib.2024.12.039","url":null,"abstract":"<div><div>Neurotransmitters are increasingly recognized to play important roles in limiting anti-tumor immunity. N-acetyl-aspartyl-glutamate (NAAG) has been extensively studied in neurological disorders; however, its potential role in restricting anti-tumor immunity has not been investigated. Here, we demonstrated that NAAG or its synthetase RimK-like family member B (RIMKLB) significantly disrupted anti-tumor immunity by rewiring the myeloid progenitor differentiation of polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs), which in turn promoted breast cancer growth and metastasis. Mechanistically, NAAG sustained the tumor immunosuppressive microenvironment by activating an NR2B-containing NMDA receptor (NR2B-NMDAR)-dependent p38-NOTCH1 axis, and subsequently stimulating tumor cell migration and invasion, as well as inducing PMN-MDSC differentiation and expansion. In mouse models, RIMKLB ablation or NMDAR inhibition enhanced the efficacy of anti-PD-1 therapy and suppressed tumor progression. An analysis of clinical samples revealed that high levels of NAAG and NR2B-NMDAR predicted a poor prognosis in TNBC patients. Collectively, our findings have uncovered a signaling role for tumor-derived NAAG beyond its classic function as a neurotransmitter that can be targeted pharmacologically to enhance immunotherapy against breast cancer.</div></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"70 7","pages":"Pages 1126-1138"},"PeriodicalIF":18.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A lectin receptor-like kinase TaSRK that is deacetylated by TaHDA9 regulates wheat grain length by mediating the photosystem II protein TaPsbO. 一种被TaHDA9去乙酰化的凝集素受体样激酶TaSRK通过介导光系统II蛋白TaPsbO来调节小麦籽粒长度。

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2025-04-15 DOI: 10.1016/j.scib.2025.04.028

Ning Zhang, Songgang Li, Zhipeng Sun, Jingjing Dai, Shuyu Zhang, Daiying Chen, Lei Zhao, Aolin Jia, Feng Chen

引用次数: 0

Nonnegligible role of small lakes in global surface water storage dynamics 小湖泊在全球地表水储存动态中不可忽视的作用。

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2025-04-15 DOI: 10.1016/j.scib.2024.12.027

Nan Xu

引用次数: 0

The dual role of electrical stimulation in pain: from management to reconstruction 电刺激在疼痛中的双重作用：从管理到重建。

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2025-04-15 DOI: 10.1016/j.scib.2025.01.052

Kehui Xu , Yuxuan Ma , Tao Ye , Yuzhu Wang , Yannan Xie , Chaohui Li , Franklin R. Tay , Lina Niu , Zhou Li , Kai Jiao

引用次数: 0

Thickness-dependent topological phases and flat bands in rhombohedral multilayer graphene 菱形多层石墨烯中厚度相关的拓扑相和平面带。

IF 18.8 1区综合性期刊

Science Bulletin Pub Date : 2025-04-15 DOI: 10.1016/j.scib.2025.01.036

Hanbo Xiao , Cheng Chen , Xin Sui , Shihao Zhang , Mengzhao Sun , Han Gao , Qi Jiang , Qiao Li , Lexian Yang , Mao Ye , Fangyuan Zhu , Meixiao Wang , Jianpeng Liu , Zhibin Zhang , Zhujun Wang , Yulin Chen , Kaihui Liu , Zhongkai Liu

引用次数: 0