Science BulletinPub Date : 2025-05-23DOI: 10.1016/j.scib.2025.05.025
Jiale Liu, Yang-Yang Zhang, Ning Pan, Shiyuan Feng, Guohui Yang, Guohao Zhang, Qiuhong Zhu, Xiaoan Li, Jun-Jie Song, Jun Li, Xiaoqin Nie
{"title":"Remarkable performance and physical origins of a multi-site functional material for <sup>131</sup>I-ion exchange in nuclear medical wastewater.","authors":"Jiale Liu, Yang-Yang Zhang, Ning Pan, Shiyuan Feng, Guohui Yang, Guohao Zhang, Qiuhong Zhu, Xiaoan Li, Jun-Jie Song, Jun Li, Xiaoqin Nie","doi":"10.1016/j.scib.2025.05.025","DOIUrl":"https://doi.org/10.1016/j.scib.2025.05.025","url":null,"abstract":"<p><p>Rapid treatment of radioactive wastewater is critical for radiological medical diagnosis and therapy. An efficient yet cost-effective adsorbent capable of selectively removing radioactive nuclides is highly desired to meet the growing global demand for nuclear medicine. In this study, a simple one-step chemical grafting strategy was employed to directly synthesize a multi-site functional fiber containing quaternary ammonium chloride (-NR<sub>3</sub><sup>+</sup>Cl<sup>-</sup>) and protonated secondary amine (-NH<sub>2</sub><sup>+</sup>-). This novel material exhibits a remarkably high <sup>131</sup>I<sup>-</sup> adsorption capacity, significantly outperforming commercial adsorbents. When applied to real hospital radioactive wastewater containing <sup>131</sup>I, it reduces the total β-activity concentration to 4.63 Bq L<sup>-1</sup>, well below the stringent global discharge standard of 10 Bq L<sup>-1</sup>. Quantum-chemical studies elucidate the mechanism underlying its exceptional adsorption capacity and the physical origin of ion exchange. This work not only provides critical insights into the nature of high-performance ion exchange but also presents a promising practical approach for highly efficient capture of <sup>131</sup>I from nuclear wastewater.</p>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144245531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Science BulletinPub Date : 2025-05-21DOI: 10.1016/j.scib.2025.05.023
Jie Jiang, Tianjun Zhou, Wenxia Zhang
{"title":"Aerosol mitigation matters to future water availability in the global monsoon region.","authors":"Jie Jiang, Tianjun Zhou, Wenxia Zhang","doi":"10.1016/j.scib.2025.05.023","DOIUrl":"https://doi.org/10.1016/j.scib.2025.05.023","url":null,"abstract":"<p><p>Water availability, as measured by precipitation minus evaporation (P-E), is projected to increase in the 21st century across the global monsoon region. However, while the impacts of increased greenhouse gas (GHG) concentrations are highlighted in existing studies, the contribution of reduced anthropogenic aerosol (AA) emissions is likely to be overlooked. Here, utilizing single-forcing projections under the SSP2-4.5 scenario, we elucidate the fingerprints of GHG and AA forcings on future P-E evolution. We reveal that future P-E changes are primarily driven by changes during the wet season, with contrasting trends between the Asian-African and American monsoon domains. The escalation of GHG concentrations is projected to increase P-E over Asian-African monsoon domains while decreasing it over the American monsoon domains. Conversely, aerosol reductions will drive a transition from current widespread drying to future wetting, with contributions comparable to GHG forcing over the Asian-African monsoon domains. While GHG increases and AA reductions can elevate atmospheric moistening through radiative warming, the disparate P-E responses arise from dynamic processes that favor drying trends in the American monsoon domains under GHG forcing. In contrast, strengthened monsoon circulations contribute to a wetting trend in the Asian-African monsoon domains under AA reductions, attributable to greater interhemispheric thermal contrast. Our findings highlight the importance of considering aerosol mitigation in climate risk assessments for densely populated monsoon regions.</p>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144197932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Science BulletinPub Date : 2025-05-20DOI: 10.1016/j.scib.2025.04.076
Yanbin Hao, Xin Wang, Tong Zhao, Kai Xue, Jianqing Du, Xiaoyong Cui, Yanfen Wang
{"title":"A framework for quantifying state transitions in complex ecosystems using energy flow networks.","authors":"Yanbin Hao, Xin Wang, Tong Zhao, Kai Xue, Jianqing Du, Xiaoyong Cui, Yanfen Wang","doi":"10.1016/j.scib.2025.04.076","DOIUrl":"https://doi.org/10.1016/j.scib.2025.04.076","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144223915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Science BulletinPub Date : 2025-05-16DOI: 10.1016/j.scib.2025.03.061
Mingxing Chen, Liangkan Chen, Michael E Meadows, Dadao Lu, Yansui Liu, Yu Deng, Longwu Liang, Chao Fan
{"title":"Unveiling disparate urban-rural relations in China through catchment area mapping.","authors":"Mingxing Chen, Liangkan Chen, Michael E Meadows, Dadao Lu, Yansui Liu, Yu Deng, Longwu Liang, Chao Fan","doi":"10.1016/j.scib.2025.03.061","DOIUrl":"https://doi.org/10.1016/j.scib.2025.03.061","url":null,"abstract":"<p><p>Sustainable urbanization in the Global South demands a comprehensive understanding of the intricate urban-rural relations in the face of rapid transformation. Traditional dichotomous urban-rural classification fails to thoroughly capture the convoluted interactions within the increasingly complex urbanizing landscape. Here, we reconstruct the urban-rural relationship in China by employing high-resolution satellite land-cover data in an urban-rural catchment area (URCA) framework to redefine urban-rural boundaries and quantify fine-grained connectivity. We categorize land areas into urban centers, peri-urban regions, rural areas, and hinterlands, revealing their respective population distributions in 2018. Our findings show significant spatial disparities in China's urban-rural relations due to transitioning from a predominantly rural to an urbanizing nation. The study also highlights substantial supply-demand inconsistencies in public infrastructure and fiscal preferences, exacerbating social expenditure gaps among municipal levels within the URCA. Our research contributes to understanding geographic social integration in urban-rural relations, which is important to promoting social justice and mitigating inequalities associated with China's urbanization in the context of the Sustainable Development Goals (SDGs).</p>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144245533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Science BulletinPub Date : 2025-05-16DOI: 10.1016/j.scib.2025.05.019
Liyun Chen, Qian Wu, Chaohui Lin, Zijun Song, Yunxing Su, Chaodong Ge, Xue Wang, Hongbing Luo, Rong Wang, Yanfang Wang, Junxia Min, Fudi Wang
{"title":"Integrative analysis of copper dysregulation and cuproptosis in postnatal hematopoiesis.","authors":"Liyun Chen, Qian Wu, Chaohui Lin, Zijun Song, Yunxing Su, Chaodong Ge, Xue Wang, Hongbing Luo, Rong Wang, Yanfang Wang, Junxia Min, Fudi Wang","doi":"10.1016/j.scib.2025.05.019","DOIUrl":"https://doi.org/10.1016/j.scib.2025.05.019","url":null,"abstract":"<p><p>Copper dysregulation has been linked to human health, disorders, and hematopoiesis. However, the underlying mechanisms remain elusive. Here, we demonstrate the pivotal role of dietary copper via the transporter Slc31a1(Ctr1) in copper homeostasis, but not cuproptosis, during postnatal hematopoiesis. Specifically, Slc31a1-mediated copper uptake sustains the differentiation and commitment of multipotent progenitors from short-term hematopoietic stem cells (HSCs). Using transcriptomic analyses, we reveal a disrupted differentiation program in hematopoietic stem and progenitor cells (HSPCs) in diet-induced copper-deficient mice or hematopoietic-specific Slc31a1 knockout (vKO) mice. Further, we show that Slc31a1 and copper are indispensable for sustaining mitochondrial activity via regulating Mtco1 and Mtco2 (subunits of Complex IV) within HSPCs. Notably, we show that the chemical compound elesclomol, also well-known as a potent cuproptosis agonist, significantly alleviates severe anemia and partially recovers HSPC mitochondrial function in vKO mice via its activity as a copper ionophore, but with no effect on cuproptosis. We thus renamed elesclomol as CupriActivitor1(CuA1), which is a more specific and descriptive term. These findings demonstrate the critical role and mechanism of copper, Slc31a1, and CuA1 in maintaining HSC homeostasis via modulation of mitochondrial energy metabolism. The study sheds light on the molecular basis of HSC fate decisions by copper or CuA1 and opens new avenues for the development of novel therapeutic strategies for copper-related disorders and blood diseases. Given the critical and multifaceted nature of copper, we propose establishing a novel interdisciplinary field termed \"Cuprology\". This discipline will advance our understanding of copper's roles in physiological and pathological processes.</p>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144232868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Science BulletinPub Date : 2025-05-15DOI: 10.1016/j.scib.2025.05.017
Jiawen Zhang, Yifan Chen, Yiming Zhong, Yuehong Wang, Honghao Huang, Wei Xu, Wenhai Pan, Lei Chen, Yichun Zhu, Evelyne Bischof, Jun Pu
{"title":"Intermittent fasting and cardiovascular health: a circadian rhythm-based approach.","authors":"Jiawen Zhang, Yifan Chen, Yiming Zhong, Yuehong Wang, Honghao Huang, Wei Xu, Wenhai Pan, Lei Chen, Yichun Zhu, Evelyne Bischof, Jun Pu","doi":"10.1016/j.scib.2025.05.017","DOIUrl":"https://doi.org/10.1016/j.scib.2025.05.017","url":null,"abstract":"<p><p>Intermittent fasting (IF) is increasingly recognized as an effective dietary intervention for slowing aging process and alleviating metabolic disturbances in multiple chronic diseases, especially in cardiovascular diseases (CVDs). Despite recent progress, the mechanisms behind its effects on cardiovascular health from the perspective of circadian rhythms are not yet fully understood. This review aims to explore the interaction between IF and circadian rhythms, focusing on their combined effects on cardiometabolic risks and cardiovascular outcomes. Evidence from animal models and clinical trials suggests that IF provides protective effects against cardiac damage and dysfunction. It is also indicated that IF influences key cardiometabolic risk factors, such as insulin sensitivity, inflammation, and lipid metabolism, by aligning with the intrinsic biological rhythms. Additionally, we discuss the therapeutic potential of IF in cardiovascular outcomes, particularly in individuals with circadian disruptions. This review also highlights future research directions to identify the most effective fasting protocols and assess the long-term cardiovascular benefits of IF in disease prevention and treatment.</p>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144245528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}