Science Bulletin最新文献

{"title":"Aging-remodeled microenvironment regulates tumor evolution and the clinical implications","authors":"Xiang Qin, Xunwei Shi, Pu Xu, Xiaodie Li, Yiyao Liu","doi":"10.1016/j.scib.2026.07.070","DOIUrl":"10.1016/j.scib.2026.07.070","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 18","pages":"Pages 4582-4584"},"PeriodicalIF":20.7,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148757290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-level estrogen impairs memory via estrogen receptor signaling in a hypothalamic–hippocampal neural circuit","authors":"Xin Li,&nbsp;Nan Zang,&nbsp;Qianru Zhao,&nbsp;Yuxiang Sun,&nbsp;Udhaya Kumar Siva Kumar,&nbsp;Mengyu Hua,&nbsp;Wenjun Zhou,&nbsp;Yanyan Qi,&nbsp;Hu Chen,&nbsp;Longqing Xia,&nbsp;Jun Qin,&nbsp;Lei Sun,&nbsp;Chaitra Rai,&nbsp;Chao Cheng,&nbsp;Zhandong Liu,&nbsp;Li Chen,&nbsp;Yong Xu,&nbsp;Zhaoyong Hu,&nbsp;Hongjie Li,&nbsp;Xinguo Hou,&nbsp;Zheng Sun","doi":"10.1016/j.scib.2026.08.057","DOIUrl":"10.1016/j.scib.2026.08.057","url":null,"abstract":"<div><div>Normal estrogen exposure, as observed in eumenorrheic women of reproductive age, is important for neurocognition, as demonstrated by postmenopausal hormone replacement. However, the cognitive effects of sustained high-level estrogen in the context of oral contraceptives or pregnancy are unclear. Here, we show that high estrogen induces temporary memory dysfunction in mice without affecting mood-related behaviors or exploratory motivation, which is associated with altered gene expression in the lateral hypothalamus (LH). Depletion of neuronal estrogen receptor α/β (ERα/β) in the LH rescues estrogen- or pregnancy-induced cognitive dysfunction. Single-nucleus RNA-seq revealed that ERα, the predominant ER in the LH, is enriched in Gamma-Aminobutyric Acid-releasing (GABAergic) neurons and that high-level estrogen downregulates GABA-A receptor signaling within LH^GABA neurons, concurrent with increased spontaneous firing activity of LH^GABA neurons during high estrogen exposure or pregnancy. LH^GABA neurons project to the hippocampal Cornu Ammonis 3 (CA3). Chemogenetic suppression of CA3-projecting LH^GABA neurons protects against high estrogen-induced cognitive dysfunction, while activation of CA3-projecting LH^GABA neurons causes cognitive dysfunction. Lastly, we observed task-specific memory impairment in women during late pregnancy, which was associated with elevated circulating estrogen levels even after correcting for other covariates. These findings delineate a molecular and neural mechanism underlying the cognitive effects of high-level estrogen, with implications for understanding the brain fog associated with pregnancy or oral contraceptives.</div></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 18","pages":"Pages 4762-4779"},"PeriodicalIF":20.7,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148878913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A printable meta-assembly strategy for scalable structural coloration.","authors":"Chen Chen, Yadong Yin","doi":"10.1016/j.scib.2026.09.085","DOIUrl":"https://doi.org/10.1016/j.scib.2026.09.085","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":20.7,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In situ generation of NKG2D CAR T/NK cells via a tumor-targeted lipoplex for enhancing cancer immunotherapy","authors":"Xiaoxuan Xu,&nbsp;Wenzhe Yi,&nbsp;Xiangshi Sun,&nbsp;Zhiwen Zhao,&nbsp;Jialin Duan,&nbsp;Ting Wu,&nbsp;Xiaoting Shan,&nbsp;Jie Li,&nbsp;Dangge Wang,&nbsp;Yaping Li","doi":"10.1016/j.scib.2026.08.006","DOIUrl":"10.1016/j.scib.2026.08.006","url":null,"abstract":"<div>The efficacy of conventional <em>in vivo</em> CAR therapy is compromised by the biophysical barrier of tumor infiltration. Here, this work develops a lipoplex-based, tumor-penetrating and hypoxia-responsive <em>in vivo</em> CAR strategy that enables <em>in situ</em> CAR-T/NK engineering within solid tumors, thereby enhancing immunotherapy against triple-negative breast cancer.</div><div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (277KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 18","pages":"Pages 4606-4610"},"PeriodicalIF":20.7,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148719531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cracking bacterial persisters: from molecular mechanisms and host adaptation to novel methodologies and countermeasures","authors":"Feilong Zhang,&nbsp;Lin Yang,&nbsp;Xuelian Wang,&nbsp;Binghuai Lu,&nbsp;Bin Cao","doi":"10.1016/j.scib.2026.08.028","DOIUrl":"10.1016/j.scib.2026.08.028","url":null,"abstract":"<div><div>Persisters represent phenotypic tolerance characterized by a MIC value within the susceptible range, along with reduced metabolic activity marked by ATP depletion, a feature likely implicated in persistent and recurrent infections. Although prior research has addressed certain issues associated with persisters, the latest research advances spanning from bacterial physiology to host-pathogen interactions are lacking. Therefore, this review aims to elucidate the definition, distinction, formation mechanisms, host-pathogen adaptation, novel methodologies, and eradication strategies related to bacterial persistence, while highlighting recent advances and prospects pertinent to bacterial persistence. This review seeks to consolidate extant knowledge as a foundational resource for mechanistic and intervention studies and inspire innovative approaches to combat persistent infections.</div></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 18","pages":"Pages 4822-4849"},"PeriodicalIF":20.7,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148849575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early and prolonged oral edaravone for neuroprotection in acute ischemic stroke: the ERASE-STROKE randomized controlled phase 3 trial","authors":"Yang Xiang,&nbsp;Wang-Sheng Jin,&nbsp;Xin-Chen Zhu,&nbsp;Yan Song,&nbsp;Xiao Chen,&nbsp;Qing-Hua Wang,&nbsp;Hao-Lun Sun,&nbsp;Yang Zhao,&nbsp;Xiao-Rong Yu,&nbsp;Tao Feng,&nbsp;Ai-Hong Guo,&nbsp;Hong-Guo Dai,&nbsp;Han-Ning Huang,&nbsp;Jing-Xian Fang,&nbsp;Ming-Hua Wang,&nbsp;Yu-Mei Peng,&nbsp;Xiao-Mei Liu,&nbsp;Xian-Le Bu,&nbsp;Yu-Hui Liu,&nbsp;Meng Zhang,&nbsp;Wei Du","doi":"10.1016/j.scib.2026.08.038","DOIUrl":"10.1016/j.scib.2026.08.038","url":null,"abstract":"<div><div>The optimal timing and duration of neuroprotective therapy for acute ischemic stroke (AIS) remain unclear. Previous studies showed benefits of edaravone treatment when started within 48 h of AIS onset for 14 d, but it remains unknown whether earlier initiation (within 24 h of onset) and longer treatment (28 d) can yield better outcomes. In ERASE-STROKE, oral edaravone (TTYP01) was demonstrated to improve functional outcomes in patients with AIS. Here, to evaluate the neuroprotective effects of TTYP01, a phase 3, multicenter, double-blind trial was conducted among patients with disabling anterior circulation stroke who did not undergo reperfusion therapy. Within 24 h of symptom onset, 614 eligible patients were randomly assigned to receive TTYP01 60 mg or placebo twice daily for 28 d plus standard care. The primary endpoint was excellent functional outcome (mRS score 0–1) at 90 d. Among 614 patients in the intention-to-treat population, excellent outcome was achieved in 65.4% with TTYP01 vs. 47.1% with placebo (odds ratio 2.12; 95% CI 1.53–2.94; <em>P</em> &lt; 0.001). Rates of symptomatic intracranial hemorrhage, mortality, and serious adverse events did not differ significantly. In patients with disabling anterior circulation stroke not receiving reperfusion, 28-d TTYP01 is safe and improves functional recovery. ClinicalTrials.gov: NCT06648304; Chinese Drug Clinical Trial Registry: CTR20230707.</div></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 18","pages":"Pages 4790-4799"},"PeriodicalIF":20.7,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148904516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Closing the comparability gap in mCDR with Triple REAL filters","authors":"Quanrui Chen,&nbsp;Yuxian Lai,&nbsp;Helmuth Thomas,&nbsp;Nianzhi Jiao","doi":"10.1016/j.scib.2026.06.038","DOIUrl":"10.1016/j.scib.2026.06.038","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 18","pages":"Pages 4589-4593"},"PeriodicalIF":20.7,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148496929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimating the economic burden of Parkinson’s disease in China, 2020–2040: a projection and health-augmented macroeconomic modelling study","authors":"Yuheng Luo,&nbsp;Xue Zhong,&nbsp;Zhong Cao,&nbsp;Klaus Prettner,&nbsp;Michael Kuhn,&nbsp;Till Winfried Bärnighausen,&nbsp;David E. Bloom,&nbsp;Simiao Chen,&nbsp;Maigeng Zhou","doi":"10.1016/j.scib.2026.08.035","DOIUrl":"10.1016/j.scib.2026.08.035","url":null,"abstract":"<div><div>Parkinson’s disease (PD) is a growing global health concern. The goal of this research is to estimate the financial impact of PD in 31 provinces in the mainland of China from 2020 to 2040. The study gathered several datasets including China Statistical Yearbook, China Labor Statistical Yearbook, China Health Statistical Yearbook, and the Global Burden of Disease study 2023. We leveraged a health-augmented macroeconomic model to calculate the provincial economic toll of PD, taking into consideration the direct and indirect effects of PD-related deaths and illness on labor supply, and variations in educational background and work experience by sex and age. PD is expected to cause a substantial economic burden from 2020 to 2040, amounting to 473 billion Chinese yuan (CNY), which is 0.017% of the gross domestic product. The burden is highest in Jiangsu, Guangdong, and Shandong Provinces, whereas the burden proportion in the provincial gross domestic product is highest in Heilongjiang at 0.029%, and the economic burden per capita is highest in Shanghai at 868 CNY. A strong positive correlation between disability-adjusted life years and economic burden is found (Pearson correlation coefficient = 0.871, <em>P</em>-value &lt; 0.001). These findings demonstrate the need for more specific regional health policies in line with the long-term care, diagnosis, and treatment for PD across China.</div></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 18","pages":"Pages 4780-4789"},"PeriodicalIF":20.7,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148872563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Catchment land use shapes lake-atmosphere thermal contrast and synchrony globally","authors":"Zhirong Yu,&nbsp;Gang Li,&nbsp;R. Iestyn Woolway,&nbsp;Jixiang Yang,&nbsp;Jiaming Hu,&nbsp;Juan Tao,&nbsp;Kun Shan,&nbsp;Kun Shi,&nbsp;Yunlin Zhang,&nbsp;Lian Feng,&nbsp;Erik Jeppesen,&nbsp;Qichao Zhou","doi":"10.1016/j.scib.2026.08.040","DOIUrl":"10.1016/j.scib.2026.08.040","url":null,"abstract":"<div><div>Lakes are integral components of the Earth system, regulating regional climate through exchanges of heat and moisture with the atmosphere. However, how catchment land use shapes lake-air thermal relationships at the global scale remains poorly understood. Here, we analyze 1036 large lakes (&gt;100 km²) worldwide during 1992–2020 to quantify changes in lake-atmosphere thermal contrast and synchrony, which we define, respectively, as the difference (<em>T</em>_diff) and sensitivity (<em>T</em>_sens) between lake surface water temperature and air temperature. Across lakes, <em>T</em>_diff declined in 79.0% of sites, while <em>T</em>_sens increased in 66.8%, indicating a widespread reduction in thermal contrast alongside strengthened lake-atmosphere synchrony. These trends varied systematically by basin type: the largest declines in <em>T</em>_diff occurred in grassland/barren-dominated basins (−0.12 °C (10 a)⁻¹), while increases in <em>T</em>_sens were significantly greater in forest- and grassland/barren-dominated basins than in cropland-dominated basins. Structural equation modeling shows that land use influences thermal contrast and synchrony both directly and indirectly through its effects on local climate, with the strongest total effects in grassland/barren-dominated basins (0.44), followed by forest-dominated (−0.28) and cropland-dominated basins (0.13). Our analysis suggests that greater land-use diversity can dampen trends in both thermal contrast and synchrony. Future projections suggest continued declines in <em>T</em>_diff and increases in <em>T</em>_sens throughout the 21st century, with land use modulating the magnitude of these changes. Together, these findings identify catchment land use as a critical yet underappreciated regulator of lake-atmosphere thermal dynamics and highlight the importance of integrating land-use considerations in lake management strategies.</div></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 18","pages":"Pages 4810-4821"},"PeriodicalIF":20.7,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148885995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Succinate antagonizes α-ketoglutarate biosynthesis governing myeloid differentiation in normal hematopoiesis and myelodysplastic syndromes","authors":"Lingling Zhang,&nbsp;Leiming Liu,&nbsp;Yue Wang,&nbsp;Aoxue Wang,&nbsp;Weitao Tang,&nbsp;Yike Song,&nbsp;Zhuo Zhang,&nbsp;Yaqiong Chen,&nbsp;Dandan Liao,&nbsp;Huixian Liang,&nbsp;Fan Yang,&nbsp;Yiming Liu,&nbsp;Jiaying Zhou,&nbsp;Yan Xuan,&nbsp;Ke Yao,&nbsp;Zeping Hu,&nbsp;Leimin Sun,&nbsp;Dan Chen,&nbsp;Ruikun He,&nbsp;Yihan Zhang,&nbsp;Zhenyu Ju","doi":"10.1016/j.scib.2026.06.007","DOIUrl":"10.1016/j.scib.2026.06.007","url":null,"abstract":"<div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (99KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 18","pages":"Pages 4621-4625"},"PeriodicalIF":20.7,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148222365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}