Science Bulletin最新文献

{"title":"A facile route to synthesize cubic gauche polymeric nitrogen.","authors":"Runteng Chen, Jun Zhang, Zelong Wang, Ke Lu, Yi Peng, Jianfa Zhao, Xiaodong Liu, Shaomin Feng, Ruibin Liu, Chuan Xiao, Changqing Jin","doi":"10.1016/j.scib.2024.11.004","DOIUrl":"https://doi.org/10.1016/j.scib.2024.11.004","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intratumoral lactic acid neutralization strategy for boosting chemoimmunotherapy using liposomal sodium bicarbonate.","authors":"Taoxing Peng, Xinyue Shao, Wenqin Song, Weihua Xu, Wei Xiong, Yihao He, Yang Ding, Yongzhuo Huang","doi":"10.1016/j.scib.2024.08.042","DOIUrl":"https://doi.org/10.1016/j.scib.2024.08.042","url":null,"abstract":"<p><p>Glycolysis-related lactic acid overproduction creates an \"ion-trapping\" barrier and immunosuppressive tumor microenvironment that compromise effective intratumoral drug delivery and therapy. Therefore, normalization of tumor microenvironment via lactic acid neutralization can be a promising avenue for overcoming this therapeutic hurdle. In this study, the flexible liposomes loaded with sodium bicarbonate (NaHCO₃@Flip) were used as a nano-adjuvant to boost chemoimmunotherapy. Their effects on assisting DOXIL and anti-programmed cell death protein 1 (PD-1) therapy were investigated. NaHCO₃@Flip achieved deep tumor penetration, with the ability to neutralize lactic acid and normalize the acidic tumor microenvironment. NaHCO₃@Flip is biosafe and can enhance cellular uptake efficiency of doxorubicin (DOX) by overcoming the ion-trapping barrier and amplify immunogenic cell death induced by DOX. The combination therapy of liposomal DOX and NaHCO₃@Flip demonstrated enhanced inhibition of tumor growth. NaHCO₃@Flip can also synergize with PD-1 antibody therapy. NaHCO₃@Flip has the potential to serve as a therapeutic adjuvant for boosting chemoimmunotherapy by overcoming the ion-trapping effect and normalizing the tumor microenvironment.</p>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urine multi-omics markers to predict seizure one day in advance.","authors":"Wanlin Lai, Leihao Sha, Rui Li, Shan Yu, Ling Jin, Ruiqi Yang, Chao Yang, Lei Chen","doi":"10.1016/j.scib.2024.10.035","DOIUrl":"https://doi.org/10.1016/j.scib.2024.10.035","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of common upper gastrointestinal diseases in Chinese adults aged 18-64 years.","authors":"Hong Yang, Mei Zhang, Hui Li, Zhengjing Huang, Yuanyuan Sun, Wenbo Li, Chun Li, Xuzhen Qin, Yanhong Wang, Xiao Zhang, Zhenping Zhao, Limin Wang, Li Wang, Jiaming Qian","doi":"10.1016/j.scib.2024.07.048","DOIUrl":"https://doi.org/10.1016/j.scib.2024.07.048","url":null,"abstract":"<p><p>To investigate the prevalence of gastroesophageal reflux disease (GERD), reflux esophagitis (RE), digestive ulcer gastric ulcer (GU), duodenal ulcer (DU), and Helicobacter pylori infection in Chinese adults aged 18-64 years and their associated factors, a community-based cross-sectional study using a stratified multistage sampling method was conducted. A standardized questionnaire survey, the ¹³C-urea breath test, and gastroscopy were performed. Weighted methods were used to estimate the prevalence of diseases or infection mentioned above and their risk factors. Finally, 27,637 participants aged 18-64 years were enrolled from 2017 to 2018. The prevalence (95% confidence interval) of GERD, RE, GU, DU, and H. pylori infection was estimated to be 10.5% (7.8%-14.2%), 5.4% (3.9%-7.3%), 2.5% (1.7%-3.7%), 4.5% (3.6%-5.4%), and 41.5% (36.7%-46.4%), respectively. The fraction of H. pylori infection reached 58.6% and 61.1% among the GU and DU patients, respectively. Weighted multivariable logistic regression models showed that GERD, RE, and GU shared the common risk factors of age and obesity. Dose-response relationships were observed between smoking and all four diseases, as well as alcohol consumption and GERD and H. pylori infection. Northwest China had the highest prevalence of GERD (23.9%), RE (8.7%), GU (7.8%), DU (7.3%), and H. pylori infection (63.6%); however, the southwest region had the highest prevalence of GU but the lowest of DU, RE, and H. pylori infection. Non-steroidal anti-inflammatory drugs were positively associated with GERD risk. On the contrary, a reduced risk of GU was observed among H. pylori-infected patients taking this drug. In summary, the prevalence of GERD, RE, and H. pylori infection still appears high in China. H. pylori infection eradication remains the priority to reduce the burden of peptic ulcer disease. The aging population, high prevalence of overweight or obesity, smoking, and drinking in China could explain the high burden of these diseases, thus suggesting the targeted preventive measures for upper gastrointestinal diseases in the future.</p>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142674777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In situ synthetic C encapsulated δ-MnO₂ with O vacancies: A versatile programming in bio-engineering.","authors":"Wei Lv, Zilei Shen, Junlin Liu, Xudong Li, Fang Ding, Dongyue Zhang, Licheng Miao, Xuefeng Lyu, Ruijie Li, Miaomiao Wang, Yiming Li, Jingwen Meng, Chao Xu","doi":"10.1016/j.scib.2024.10.034","DOIUrl":"https://doi.org/10.1016/j.scib.2024.10.034","url":null,"abstract":"<p><p>In this study, we successfully synthesized a δ-MnO₂ cathode with O vacancies, encapsulated by C derived from pyromellitic acid, using a facile hydrothermal method followed by annealing in an Ar atmosphere. The cathode's structural stability and charge transfer kinetics are enhanced by inhibiting the formation of the by-product Zn₄SO₄(OH)₆·4H₂O, regulating the Mn valence state, and suppressing the Jahn-Teller effect through the synergy of C encapsulation and O vacancies. This results in remarkable electrochemical performance, including a large capacity of 421.2 mAh g^-1 at 0.1 A g^-1, a high specific energy density of 595.53 Wh kg^-1, and exceptional long-cycle life stability with 90.88% over 4000 cycles at 10 A g^-1, together with superior coulombic efficiency (∼100%) in pure ZnSO₄ electrolyte. Moreover, the cathode materials demonstrate specific antitumor efficacy. In brief, this work introduces an in situ synthetic C encapsulated δ-MnO₂ with O vacancies expected to be applied in both large-scale energy storage and biomedicine.</p>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142643677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-atom \"surgery\" on chiral all-dialkynyl-protected superatomic silver nanoclusters.","authors":"Chengkai Zhang, Wei-Dan Si, Wei-Dong Tian, Wan-Jun Xiao, Zhi-Yong Gao, Zhi Wang, Chen-Ho Tung, Di Sun","doi":"10.1016/j.scib.2024.11.002","DOIUrl":"https://doi.org/10.1016/j.scib.2024.11.002","url":null,"abstract":"<p><p>The manipulation of single atom within the metallic kernel of nanoclusters has attracted considerable attention due to its potentials to elucidate kernel-based structure-property relationships at the single-atom level. Herein, new-designed chiral bialkynyl ligands, have been chosen as protective agents to isolate two pairs of 8-electron superatomic silver nanoclusters, R/S-Ag39 and R/S-Ag40. X-ray diffraction analysis reveals that Ag39 and Ag40 with the same number of chiral ligands, possess a closely analogous silver skeleton but a single-atomic difference. The incorporation of an extra Ag^40th atom into Ag40 evokes two significant changes of structure and property compared to Ag39: (i) a reduction in the symmetry of the entire nanocluster, resulting in an enhancement of kernel-related asymmetry g-factor; (ii) a regulation of the transitions (1P → 1D and Ligand_(π) → 1D) of excited state, leading to a second near-infrared (NIR-II, 1000-1700 nm) phosphorescent emission red-shift from 1088 to 1150 nm. This work not only provides vital insights into the relationship between structures and ground/excited states chiroptical activities at the single-atom level, but also presents bialkynyl as a promising stabilizing agent for building superatomic metal nanoclusters.</p>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142674701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tunable refractive index transparent conductive adhesives for efficient monolithic tandem solar cells.","authors":"Xingliang Li, Sanlong Wang, Xiangqing Zhou, Yucheng Li, Hui Liu, Biao Shi, Qiang Sun, Ying Zhao, Xiaodan Zhang","doi":"10.1016/j.scib.2024.10.033","DOIUrl":"https://doi.org/10.1016/j.scib.2024.10.033","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging brain white matter function using resting-state functional MRI.","authors":"Gong-Jun Ji, Zaixu Cui, Ryan C N D'Arcy, Wei Liao, Bharat B Biswal, Qing Zhang, Cheng Luo, Yu-Feng Zang, Zhaohua Ding, Xi-Nian Zuo, John C Gore, Kai Wang","doi":"10.1016/j.scib.2024.11.001","DOIUrl":"https://doi.org/10.1016/j.scib.2024.11.001","url":null,"abstract":"","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vivo self-assembled bispecific fluorescence probe for early detection of bladder cancer and metastasis.","authors":"Da-Yong Hou, Ni-Yuan Zhang, Peng Zhang, Xiang-Peng Li, Jiong-Cheng Wu, Mei-Yu Lv, Zhi-Jia Wang, Xing-Jie Hu, Jian-Xiao Liang, Hong-Lei Wang, Yue-Ze Wang, Hui-Hui You, Hong-Wei An, Hao Wang, Wanhai Xu","doi":"10.1016/j.scib.2024.10.032","DOIUrl":"https://doi.org/10.1016/j.scib.2024.10.032","url":null,"abstract":"<p><p>Tumor metastasis accounts for over 90% of tumor-related deaths, prompting the development of fluorescently labeled tumor-specific molecular imaging agents for differentiating tumors from normal tissues. However, early detection of metastasis lesions by tracking tumor markers alone has proven to be challenging. Herein, we reported a glycopeptide-based bispecific fluorescence probe (bsProbe) for earlier detection of bladder cancer and metastasis. By simultaneously recognition (tumor & tumor microenvironment) and in vivo self-assembly, the tumor accumulation of bsProbe (12.3% ID/g) was obviously increased by ∼6 fold compared with that in CXCR4 specific fluorescence probe (sProbe), indicating the obvious advantages of bsProbe over existing tumor metastasis detection probes. Additionally, bsProbe substantially broadens the tumor diagnosis window and enhances the detection signal to noise ratio (SNR: approximately 9.5), permitting early diagnosis of lung micro-metastasis (∼1 mm), precise identifying of tumor boundaries and micro-tumors in orthotopic tumor models. More importantly, bsProbe was demonstrated to distinguish malignant from benign specimen with a specificity of 90.48% and sensitivity of 92.22% in 195 clinical specimens of bladder cancer patients. Taken together, this novel synergetic targeting (CD206 × CXCR4) strategy provides an attractive method for earlier detection of bladder cancer and metastasis, which might be further extended to the imaging-guided surgery of clinical invisible tumors.</p>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":18.8,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceptible landscape patterns reveal invisible socioeconomic profiles of cities","authors":"","doi":"10.1016/j.scib.2024.06.022","DOIUrl":"10.1016/j.scib.2024.06.022","url":null,"abstract":"<div><div>Urban landscape is directly perceived by residents and is a significant symbol of urbanization development. A comprehensive assessment of urban landscapes is crucial for guiding the development of inclusive, resilient, and sustainable cities and human settlements. Previous studies have primarily analyzed two-dimensional landscape indicators derived from satellite remote sensing<span>, potentially overlooking the valuable insights provided by the three-dimensional configuration of landscapes. This limitation arises from the high cost of acquiring large-area three-dimensional data and the lack of effective assessment indicators. Here, we propose four urban landscapes indicators in three dimensions (UL3D): greenness, grayness, openness, and crowding. We construct the UL3D using 4.03 million street view images from 303 major cities in China, employing a deep learning approach. We combine urban background and two-dimensional urban landscape indicators with UL3D to predict the socioeconomic profiles of cities. The results show that UL3D indicators differs from two-dimensional landscape indicators, with a low average correlation coefficient of 0.31 between them. Urban landscapes had a changing point in 2018–2019 due to new urbanization initiatives, with grayness and crowding rates slowing, while openness increased. The incorporation of UL3D indicators significantly enhances the explanatory power of the regression model for predicting socioeconomic profiles. Specifically, GDP per capita, urban population rate, built-up area per capita, and hospital count correspond to improvements of 25.0%, 19.8%, 35.5%, and 19.2%, respectively. These findings indicate that UL3D indicators have the potential to reflect the socioeconomic profiles of cities.</span></div></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"69 20","pages":"Pages 3291-3302"},"PeriodicalIF":18.8,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141537301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}