{"title":"Microbiota-derived metabolites in the epigenetic regulation of the host.","authors":"Junwen Lei, Xiaoyi Wang, Xingyin Liu","doi":"10.1016/j.scib.2025.09.030","DOIUrl":null,"url":null,"abstract":"<p><p>The gut microbiota plays a crucial role in maintaining host health and modulating disease progression. Microbiota-derived metabolites (MDMs) form a complex and diverse repertoire of molecules that interact uniquely with the host and regulate epigenetics. In this review, we provide a comprehensive overview by examining the current evidence on how MDMs reshape host epigenetic landscape, and we highlight the innovative concept of the \"MDMs-epigenetic (MDME) axis\" as a potential framework for exploring and understanding microbiota-host interactions. Next, we underscore the significance of the MDME axis in driving mechanistic studies and elucidating the underlying biological processes and pathophysiological pathways involved in various diseases. Finally, we discuss the impact of MDMs on epigenetic landscapes, outline future directions, and highlight their pivotal role in both mechanistic investigation and the development of clinical therapies.</p>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":21.1000,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Science Bulletin","FirstCategoryId":"103","ListUrlMain":"https://doi.org/10.1016/j.scib.2025.09.030","RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
The gut microbiota plays a crucial role in maintaining host health and modulating disease progression. Microbiota-derived metabolites (MDMs) form a complex and diverse repertoire of molecules that interact uniquely with the host and regulate epigenetics. In this review, we provide a comprehensive overview by examining the current evidence on how MDMs reshape host epigenetic landscape, and we highlight the innovative concept of the "MDMs-epigenetic (MDME) axis" as a potential framework for exploring and understanding microbiota-host interactions. Next, we underscore the significance of the MDME axis in driving mechanistic studies and elucidating the underlying biological processes and pathophysiological pathways involved in various diseases. Finally, we discuss the impact of MDMs on epigenetic landscapes, outline future directions, and highlight their pivotal role in both mechanistic investigation and the development of clinical therapies.
期刊介绍：
Science Bulletin (Sci. Bull., formerly known as Chinese Science Bulletin) is a multidisciplinary academic journal supervised by the Chinese Academy of Sciences (CAS) and co-sponsored by the CAS and the National Natural Science Foundation of China (NSFC). Sci. Bull. is a semi-monthly international journal publishing high-caliber peer-reviewed research on a broad range of natural sciences and high-tech fields on the basis of its originality, scientific significance and whether it is of general interest. In addition, we are committed to serving the scientific community with immediate, authoritative news and valuable insights into upcoming trends around the globe.
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