Science Bulletin最新文献_第7页

Biomolecular condensates from a short peptide for enhancing radiotherapy via spatial sequestration of PARP1 一种短肽的生物分子凝聚物通过PARP1的空间隔离来增强放疗。

IF 20.7 1区综合性期刊

Science Bulletin Pub Date : 2026-09-30 Epub Date: 2026-07-30 DOI: 10.1016/j.scib.2026.07.079

Xiaoyao Cai, Yipeng Cao, Hui Li, Wei Xu, Yanbin Chen, Chaoyi Lyu, Zhiyong Yuan, Yumin Zhang, Jianfeng Liu, Cuihong Yang

引用次数: 0

Data-knowledge dual-driven intelligent framework for full-chain, experiment-efficient synthesis of 2D dendrites 数据-知识双驱动的全链、实验高效二维树突合成智能框架。

IF 20.7 1区综合性期刊

Science Bulletin Pub Date : 2026-09-30 Epub Date: 2026-08-16 DOI: 10.1016/j.scib.2026.08.033

Wenqiang Huang, Xuhang Gu, Susu Fang, Shen’ao Xue, Huanhuan Xing, Junjie Jiang, Junying Zhang, Shen Zhou, Zheng Luo, Jin Zhang, Fangping Ouyang, Shanshan Wang

引用次数: 0

High-initial-efficiency sodium storage in crystalline carbon nitride mediated by quasi-metallic Zn-N₄ sites for wide-temperature batteries. 宽温电池中准金属Zn-N4位点介导的晶体氮化碳中高初始效率钠存储。

IF 20.7 1区综合性期刊

Science Bulletin Pub Date : 2026-09-30 DOI: 10.1016/j.scib.2026.09.082

Xinglong Li, Hongguan Li, Chen Liu, Zhongbiao Li, Yuxin Zhu, Shulan Wang, Maoqiao Xiang, Li Li

引用次数: 0

Megalin-targeted Mg-Fe cyanometallate framework nanozymes calibrate mitochondrial iron-calcium homeostasis to treat acute kidney injury. 靶向镁铁氰金属酸框架纳米酶校准线粒体铁钙稳态治疗急性肾损伤。

IF 20.7 1区综合性期刊

Science Bulletin Pub Date : 2026-09-30 DOI: 10.1016/j.scib.2026.09.080

Qiaohui Chen, Xiaohong Ying, Ziyu Wu, Chenxi Miao, Wan Zeng, Yikai Cai, Yayun Nan, Qiong Huang, Kelong Ai

{"title":"Megalin-targeted Mg-Fe cyanometallate framework nanozymes calibrate mitochondrial iron-calcium homeostasis to treat acute kidney injury.","authors":"Qiaohui Chen, Xiaohong Ying, Ziyu Wu, Chenxi Miao, Wan Zeng, Yikai Cai, Yayun Nan, Qiong Huang, Kelong Ai","doi":"10.1016/j.scib.2026.09.080","DOIUrl":"https://doi.org/10.1016/j.scib.2026.09.080","url":null,"abstract":"<p><p>Intracellular metal ion homeostasis, particularly the precise regulation of mitochondrial iron and calcium, is essential for maintaining energy metabolism and cell survival. Once disrupted, iron-mediated oxidative reactions and calcium overload mutually amplify, rapidly leading to mitochondrial dysfunction and cellular injury. In acute kidney injury (AKI), this mitochondria-centered iron-calcium imbalance represents a critical pathological axis driving oxidative stress, programmed cell death, and inflammation. However, effective therapies that coordinately regulate both processes are not yet available. Herein, we developed a polyvinylpyrrolidone (PVP)-coated Mg-Fe cyanometallate framework nanozyme (MFC) to calibrate iron-calcium homeostasis in AKI. The PVP coating facilitates its interaction with the highly expressed Megalin receptor in renal proximal tubular epithelial cells, promoting receptor-dependent endocytosis and tubular-targeted delivery. Built on a Prussian blue-like coordination framework, MFC efficiently captures bioactive iron to suppress oxidative stress, while its ion-exchange process concurrently releases Mg<sup>2+</sup>, acting as a physiological calcium antagonist that regulates mitochondrial calcium homeostasis. By stabilizing mitochondrial structure and function, this strategy suppresses the cascade amplification of cell death and inflammatory signaling, significantly ameliorating renal injury in AKI. This study proposes a therapeutic approach for AKI by rewiring mitochondrial iron-calcium imbalance and offers a design paradigm for multifactorially coupled diseases.</p>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":20.7,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149163998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Programmable macrophage interface engineering enables targeted antibacterial therapy in immunosuppressed infections 可编程巨噬细胞界面工程使免疫抑制感染的靶向抗菌治疗成为可能。

IF 20.7 1区综合性期刊

Science Bulletin Pub Date : 2026-09-30 Epub Date: 2026-07-06 DOI: 10.1016/j.scib.2026.07.008

Yuanfeng Li, Chang Gao, Zhanpei Bai, Yumeng Wang, Jiyang Chen, Haoyue Wu, Xiufeng Huang, Chunxiong Zheng, Xinghong Zhao, Linqi Shi, Yong Liu

{"title":"Programmable macrophage interface engineering enables targeted antibacterial therapy in immunosuppressed infections","authors":"Yuanfeng Li, Chang Gao, Zhanpei Bai, Yumeng Wang, Jiyang Chen, Haoyue Wu, Xiufeng Huang, Chunxiong Zheng, Xinghong Zhao, Linqi Shi, Yong Liu","doi":"10.1016/j.scib.2026.07.008","DOIUrl":"10.1016/j.scib.2026.07.008","url":null,"abstract":"<div><div>Severe bacterial infections remain difficult to treat due to both antimicrobial resistance and infection-induced immune dysfunction, which together limit pathogen clearance. Here, we report a non-genetic immune cell engineering strategy that increases antibacterial activity by reprogramming macrophage interfaces. Integrated analysis of clinical single-cell transcriptomic datasets from diverse infections revealed a conserved hypofunctional macrophage state characterized by impaired phagocytosis, lysosomal activity, and immune coordination. To bypass this dysfunction, we engineered macrophages using membrane-fusogenic liposomes functionalized with bacteriophage-derived receptor-binding proteins and loaded with intracellular antibiotics. This approach enables programmable, pathogen-specific recognition while delivering antimicrobial payloads within macrophages. Engineered macrophages exhibited enhanced bacterial capture, immobilization, and intracellular killing, maintaining efficacy under immunosuppressive conditions. In mouse models of <em>Klebsiella pneumoniae</em> pneumonia and <em>Staphylococcus aureus</em> meningitis, treatment resulted in near-complete pathogen clearance, reduced inflammation, and restoration of organ function. Single-cell analyses further showed reversal of immune dysfunction and reestablishment of coordinated innate and adaptive immune responses. These findings establish macrophage interface engineering as a strategy to overcome immune dysfunction and enable targeted antibacterial therapy, providing a potential platform for treating severe infections.</div></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 18","pages":"Pages 4723-4741"},"PeriodicalIF":20.7,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148454114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

External electronic effect enhances room-temperature phosphorescence and photochromism in organophosphine oxide 外部电子效应增强了氧化有机膦的室温磷光性和光致变色性。

IF 20.7 1区综合性期刊

Science Bulletin Pub Date : 2026-09-30 Epub Date: 2026-08-04 DOI: 10.1016/j.scib.2026.08.010

Zhuke Gong, Xiudan Song, Jianhui Sun, Ruotong Ma, Qingfeng Mu, Yuanting Guo, Xiaojun Zhang, Hui Xu

{"title":"External electronic effect enhances room-temperature phosphorescence and photochromism in organophosphine oxide","authors":"Zhuke Gong, Xiudan Song, Jianhui Sun, Ruotong Ma, Qingfeng Mu, Yuanting Guo, Xiaojun Zhang, Hui Xu","doi":"10.1016/j.scib.2026.08.010","DOIUrl":"10.1016/j.scib.2026.08.010","url":null,"abstract":"<div><div>Introducing both locally excited and charge transfer (CT) featured single-molecule long-lived excited states in energy transfer can optimize room-temperature phosphorescence (RTP) at molecular level, but this requires accurate energetic modulation and sequential populations of these states. Herein, we utilize intermolecular interactions between donors (D) and/or acceptors (A), namely, the external electronic effect, to modulate intramolecular CT in a linear system named POMPDPAC containing <em>N</em>-(3-methylphenyl)-9,9-diphenylacridine (MPDPAC) donor and diphenylphosphine oxide (DPPO) acceptor. Theoretical simulation and time-resolved photophysical results show that intermolecular D-A or D-D/A-A interactions give rise to two stabilized ππ* and CT-featured triplet states on a single POMPDPAC molecule in its two different dimers, whose incorporation in the RTP process establishes a step-by-step energy transfer. As a result, compared to its Br or diphenylphosphine (DPP)-modified congeners only with ππ* featured triplet states, RTP quantum yield and lifetime of POMPDPAC powder are improved as high as ∼3 and 5–11 folds, respectively, accompanied by 77% RTP ratio in photoluminescence and typical photochromic properties. This work demonstrates not only the possibility of coexistence of multiple stabilized single-molecule triplet states in organic solids, but also the feasibility of developing multifunctional “RTP+” materials.</div></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 18","pages":"Pages 4673-4683"},"PeriodicalIF":20.7,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148838849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overwhelming wetland reclamation confronts severe flood risks 压倒性的湿地填海面临严重的洪水风险。

IF 20.7 1区综合性期刊

Science Bulletin Pub Date : 2026-09-30 Epub Date: 2026-08-07 DOI: 10.1016/j.scib.2026.08.019

Xi Zhang, Jinwei Dong, Yiqun Shang, Xi Chen, Xinxin Wang, Qiang Zhang, Ruoqi Liu, Shushi Peng, Dehua Mao, Xiaogang He, Yong Ge, Xiangming Xiao

{"title":"Overwhelming wetland reclamation confronts severe flood risks","authors":"Xi Zhang, Jinwei Dong, Yiqun Shang, Xi Chen, Xinxin Wang, Qiang Zhang, Ruoqi Liu, Shushi Peng, Dehua Mao, Xiaogang He, Yong Ge, Xiangming Xiao","doi":"10.1016/j.scib.2026.08.019","DOIUrl":"10.1016/j.scib.2026.08.019","url":null,"abstract":"<div><div>Agricultural expansion under rising food demand has resulted in over half of global wetland loss, yet the flood risks faced by wetland-reclaimed croplands (WRCs) remain poorly understood. Focusing on China, a major grain-producing country with extensive wetland resources, we found that wetland reclamation converted 4818 km<sup>2</sup> of wetlands into croplands, accounting for 35% of total wetland loss from 2000 to 2020, with pronounced concentrations in Northeast China. Flood occurrence also exhibited strong spatial heterogeneity: the middle Yangtze River and Northeast China both had high baseline frequencies, but trends diverged, with 80% of pixels showing positive slopes in the former and 73% showing negative slopes in the latter. More than 70% of WRCs were located in flood-prone regions, nearly 90% had experienced at least one flood event, and over half showed increasing flood frequency. A further counterfactual analysis showed that WRCs experienced higher flood frequency relative to matched non-reclaimed areas, suggesting a potential amplification of flood risks by wetland reclamation. These findings reveal substantial flood-related sustainability challenges for cropland expansion through wetland reclamation and underscore the urgent need to reconcile food security with wetland conservation.</div></div>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":"71 18","pages":"Pages 4800-4809"},"PeriodicalIF":20.7,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrolyte-enabled reversible ICl intercalation in graphite as transition metal-free cathodes 电解使能的可逆ICl嵌入石墨作为过渡无金属阴极。

IF 20.7 1区综合性期刊

Science Bulletin Pub Date : 2026-09-30 Epub Date: 2026-08-16 DOI: 10.1016/j.scib.2026.07.081

Zhaoheng Ruan, Hao Zhang, Huipeng Zeng, Baichuan Cui, Ruifan Lin, An Phan, Chun Hu, Jijian Xu

引用次数: 0

Taming inflammation in coronary artery disease: lessons learned, translational breakthroughs, and future directions. 驯服冠状动脉疾病中的炎症：经验教训、转化突破和未来方向。

IF 20.7 1区综合性期刊

Science Bulletin Pub Date : 2026-09-30 DOI: 10.1016/j.scib.2026.09.081

Miao Yu, Ming-Yang Sun, Fen Yang, Yuan-Fan Yuan, Ying-Mei Zhang, Cheng-Chao Ruan, Yong Ji, Peter Libby, Xiang Cheng

{"title":"Taming inflammation in coronary artery disease: lessons learned, translational breakthroughs, and future directions.","authors":"Miao Yu, Ming-Yang Sun, Fen Yang, Yuan-Fan Yuan, Ying-Mei Zhang, Cheng-Chao Ruan, Yong Ji, Peter Libby, Xiang Cheng","doi":"10.1016/j.scib.2026.09.081","DOIUrl":"https://doi.org/10.1016/j.scib.2026.09.081","url":null,"abstract":"<p><p>Inflammation is an essential physiological process that preserves host homeostasis, yet chronic inflammation is now recognized as a common pathological basis of many diseases. In coronary artery disease (CAD), chronic inflammation is central to the initiation and progression of atherosclerosis. Accordingly, anti-inflammatory therapy has emerged as a major focus of investigation in this field. Although multiple inflammatory pathways have been evaluated as therapeutic targets in clinical trials, strategies with demonstrated clinical benefit remain limited. In this review, we examine the sources of inflammation in CAD, approaches to inflammatory risk stratification, and advances in anti-inflammatory therapy. To explain divergent trial outcomes and guide future clinical translation, we propose a 4R framework: the right target, the right patient, the right timing, and the right benefit-risk balance. Anti-inflammatory treatment remains promising. Within this framework, refined inflammatory phenotyping and evaluation of stage-dependent efficacy represent immediate priorities for future trials.</p>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":20.7,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149206296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamic proton reservoir with hydrogen-bond-network-mediated proton transport pathway for efficient alkaline hydrogen evolution. 具有氢键网络介导的质子传输途径的碱性氢高效析氢动态质子库。

IF 20.7 1区综合性期刊

Science Bulletin Pub Date : 2026-09-30 DOI: 10.1016/j.scib.2026.09.084

Ning Wen, Mengfan Zhao, Guihang Yu, Bin Chang, Haimei Wang, Yuanfu Ren, Pengfei Wang, Yueshuang Mao, Shifeng Huang, Yuguo Xia, Dairong Chen, Sihui Zhan, Weijia Zhou

{"title":"Dynamic proton reservoir with hydrogen-bond-network-mediated proton transport pathway for efficient alkaline hydrogen evolution.","authors":"Ning Wen, Mengfan Zhao, Guihang Yu, Bin Chang, Haimei Wang, Yuanfu Ren, Pengfei Wang, Yueshuang Mao, Shifeng Huang, Yuguo Xia, Dairong Chen, Sihui Zhan, Weijia Zhou","doi":"10.1016/j.scib.2026.09.084","DOIUrl":"https://doi.org/10.1016/j.scib.2026.09.084","url":null,"abstract":"<p><p>The alkaline hydrogen evolution reaction (HER) is intrinsically limited by the lack of active hydrogen and sluggish hydrogen transfer. However, current strategies mainly optimize catalytic sites for water splitting or hydrogen adsorption, overlooking the demands of continuous hydrogen supply and rapid hydrogen transfer. Here, we report an IrO<sub>2</sub>/WO<sub>3</sub> catalyst that enables dynamic engineering of proton reservoirs and transport pathways for accelerated alkaline HER. The catalyst exhibits exceptional alkaline HER activity, delivering an ultralow overpotential of 18 mV at 10 mA cm<sup>-2</sup> for alkaline HER. When integrated into a membrane-based alkaline electrolyzer, it achieves 1 A cm<sup>-2</sup> at only 1.68 V and retains stable performance for over 1000 h. Experimental and theoretical studies show that WO<sub>3</sub> undergoes reversible proton intercalation and deintercalation, acting as a dynamic proton reservoir. More importantly, the strong interfacial coupling between IrO<sub>2</sub> and WO<sub>3</sub> reconstructs an ordered hydrogen-bond network that serves as an efficient proton transport pathway and facilitates directional proton transfer to Ir active sites. Meanwhile, IrO<sub>2</sub> efficiently stabilizes H* intermediates, thereby accelerating H-H coupling. This work reveals the critical role of dynamic proton microenvironments in governing alkaline HER kinetics, providing a new strategy for proton-coupled electrocatalyst design.</p>","PeriodicalId":421,"journal":{"name":"Science Bulletin","volume":" ","pages":""},"PeriodicalIF":20.7,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149214872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0