综合性期刊最新文献

{"title":"Strong interactions and isospin symmetry breaking in a supermoiré lattice","authors":"Yonglong Xie, Andrew T. Pierce, Jeong Min Park, Daniel E. Parker, Jie Wang, Patrick Ledwith, Zhuozhen Cai, Kenji Watanabe, Takashi Taniguchi, Eslam Khalaf, Ashvin Vishwanath, Pablo Jarillo-Herrero, Amir Yacoby","doi":"10.1126/science.adl2544","DOIUrl":"https://doi.org/10.1126/science.adl2544","url":null,"abstract":"In multilayer moiré heterostructures, the interference of multiple twist angles ubiquitously leads to tunable ultra-long-wavelength patterns known as supermoiré lattices. However, their impact on the system’s many-body electronic phase diagram remains largely unexplored. We present local compressibility measurements revealing numerous incompressible states resulting from supermoiré-lattice-scale isospin symmetry breaking driven by strong interactions. By using the supermoiré lattice occupancy as a probe of isospin symmetry, we observe an unexpected doubling of the miniband filling near <jats:inline-formula> <mml:math xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" display=\"inline\" overflow=\"scroll\"> <mml:mrow> <mml:mtext>ν</mml:mtext> <mml:mo>=</mml:mo> <mml:mo>−</mml:mo> <mml:mn>2</mml:mn> </mml:mrow> </mml:math> </jats:inline-formula> , possibly indicating a hidden phase transition or normal-state pairing proximal to the superconducting phase. Our work establishes supermoiré lattices as a tunable parameter for designing quantum phases and an effective tool for unraveling correlated phenomena in moiré materials.","PeriodicalId":21678,"journal":{"name":"Science","volume":"27 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144547540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemoselective synthesis of 1,3,4-thiadiazoles from acyl hydrazines and nitroalkanes using elemental sulfur","authors":"Xiaonan Wang, Xiuwen Yu, Ruixi Qian, Silong Xu, Martin J. Lear, Wangxiao He, Jing Li","doi":"10.1038/s41467-025-61359-z","DOIUrl":"https://doi.org/10.1038/s41467-025-61359-z","url":null,"abstract":"<p>Substituted 1,3,4-thiadiazoles find extensive use in pharmaceutical, agricultural, and materials chemistry. The incorporation of adaptable heterocyclic pharmacophores results in tunable hybrid molecules with diverse medicinal properties. In this study, the direct coupling of primary nitroalkanes and acyl hydrazines (hydrazides) is achieved simply by the mild action of S₈ and Na₂S. This method now delivers wide varieties of multi-functionalized 1,3,4-thiadiazoles in excellent yields. The reaction is scalable, shows a broad substrate scope, and tolerates a wide range of functional groups. The power of this method is exemplified with over twenty acyl hydrazines, spanning a diverse range of nitroalkane substrate classes, as well as the concise and scalable synthesis of 1,3,4-thiadiazole derivatives of over ten distinct types of drugs and peptides.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"3 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144547545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune correlates analysis of mRNA-1345 RSV vaccine efficacy clinical trial","authors":"Chong Ma, Jiejun Du, Lan Lan, Archana Kapoor, Gonzalo Perez Marc, Gilberto Jimenez, Christopher J. A. Duncan, Nancy Le Cam, Nina Lin, Frances Priddy, Sanjay Garg, Sonia K. Stoszek, Christine A. Shaw, Jaya Goswami, Eleanor Wilson, Rituparna Das, Honghong Zhou, Lingyi Zheng","doi":"10.1038/s41467-025-61153-x","DOIUrl":"https://doi.org/10.1038/s41467-025-61153-x","url":null,"abstract":"<p>Identifying an immunologic marker as a correlate of protection (CoP) for RSV vaccination is important. In the pivotal phase 3 trial, the mRNA-1345 vaccine demonstrated efficacy against RSV in older adults (NCT05127434). Here, we evaluate neutralizing antibodies (nAb) against RSV-A and -B, and IgG binding antibodies (bAb) to RSV fusion antigens as correlates of risk (CoR) and CoP against the pivotal trial’s efficacy endpoints of RSV lower respiratory tract disease with ≥2 or ≥3 signs/symptoms (RSV-LRTD-2+ and −3 + ) and acute respiratory disease (RSV-ARD). Day 29 RSV nAb and prefusion (preF) IgG demonstrate consistent inverse correlates with RSV endpoint occurrence. Day 29 point estimates (95% CIs) of the hazard ratio of each endpoint (RSV-LRTD-2 + , RSV-LRTD-3 + , RSV-ARD) per 10-fold increase in RSV-A nAb are 0.44 (0.30-0.65), 0.41 (0.20-0.84), and 0.45 (0.28-0.71), respectively, similar to RSV-B nAb and preF IgG. These results demonstrate Day 29 RSV nAb and preF IgG are CoRs and support their role as CoPs against RSV endpoints.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"19 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144547642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How we’re rebuilding the Weizmann Institute — and our hopes for a better future","authors":"","doi":"10.1038/d41586-025-02112-w","DOIUrl":"https://doi.org/10.1038/d41586-025-02112-w","url":null,"abstract":"Scientific research is at the heart of Israel’s success and has worldwide benefits. Our work will continue despite adversity.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"645 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144547199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of proliferating neural progenitors in the adult human hippocampus","authors":"Ionut Dumitru, Marta Paterlini, Margherita Zamboni, Christoph Ziegenhain, Sarantis Giatrellis, Rasool Saghaleyni, Åsa Björklund, Kanar Alkass, Mathew Tata, Henrik Druid, Rickard Sandberg, Jonas Frisén","doi":"10.1126/science.adu9575","DOIUrl":"https://doi.org/10.1126/science.adu9575","url":null,"abstract":"Continuous adult hippocampal neurogenesis is involved in memory formation and mood regulation but is challenging to study in humans. Difficulties finding proliferating progenitor cells called into question whether and how new neurons may be generated. We analyzed the human hippocampus from birth through adulthood by single-nucleus RNA sequencing. We identified all neural progenitor cell stages in early childhood. In adults, using antibodies against the proliferation marker Ki67 and machine learning algorithms, we found proliferating neural progenitor cells. Furthermore, transcriptomic data showed that neural progenitors were localized within the dentate gyrus. The results contribute to understanding neurogenesis in adult humans.","PeriodicalId":21678,"journal":{"name":"Science","volume":"11 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144547477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Collisions in the sky","authors":"Andy Lawrence","doi":"10.1126/science.ady9838","DOIUrl":"https://doi.org/10.1126/science.ady9838","url":null,"abstract":"Over the past six decades, astronomy, space science, and the space industry have seemed to be in a kind of virtuous symbiosis. Astronomy has benefited from improvements in technology and has had the opportunity to place observing platforms in space. The space industry has been pushed by the extreme technological demands of curiosity-driven research, and benefited from the flow of public money to industrial contracts to build astronomical missions. Both science and industry have been driven by a shared romantic vision of exploring the Universe, whether by studying distant galaxies or by humanity stepping out into space. All of this was suddenly disrupted in 2019 by a rude awakening. Starlink communication satellites began to photo-bomb astronomers’ images as they streaked across the sky. Suddenly, it seemed, astronomy and commercial space activity were in conflict. This friction may be coming to a crunch as the Vera C. Rubin Observatory begins a 10-year survey of the cosmos.","PeriodicalId":21678,"journal":{"name":"Science","volume":"120 8 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144547532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumor site-directed A1R expression enhances CAR T cell function and improves efficacy against solid tumors","authors":"Kevin Sek, Amanda X. Y. Chen, Thomas Cole, Jesse D. Armitage, Junming Tong, Kah Min Yap, Isabelle Munoz, Phoebe A. Dunbar, Shiyi Wu, Marit J. van Elsas, Olivia Hidajat, Christina Scheffler, Lauren Giuffrida, Melissa A. Henderson, Deborah Meyran, Fernando Souza-Fonseca-Guimaraes, Dat Nguyen, Yu-Kuan Huang, Maria N. de Menezes, Emily B. Derrick, Cheok Weng Chan, Kirsten L. Todd, Jack D. Chan, Jasmine Li, Junyun Lai, Emma V. Petley, Sherly Mardiana, Anthony Bosco, Jason Waithman, Ian A. Parish, Christina Mølck, Gregory D. Stewart, Lev Kats, Imran G. House, Phillip K. Darcy, Paul A. Beavis","doi":"10.1038/s41467-025-59021-9","DOIUrl":"https://doi.org/10.1038/s41467-025-59021-9","url":null,"abstract":"<p>The efficacy of Chimeric Antigen Receptor T cells against solid tumors is limited by immunosuppressive factors in the tumor microenvironment including adenosine, which suppresses Chimeric Antigen Receptor T cells through activation of the A_2A receptor. To overcome this, Chimeric Antigen Receptor T cells are engineered to express A₁ receptor, a receptor that signals inversely to A_2A receptor. Using murine and human Chimeric Antigen Receptor T cells, constitutive A₁ receptor overexpression significantly enhances Chimeric Antigen Receptor T cell effector function albeit at the expense of Chimeric Antigen Receptor T cell persistence. Through a CRISPR/Cas9 homology directed repair “knock-in” approach we demonstrate that Chimeric Antigen Receptor T cells engineered to express A₁ receptor in a tumor-localized manner, enhances anti-tumor therapeutic efficacy. This is dependent on the transcription factor <i>IRF8</i> and is transcriptionally unique when compared to A_2A receptor deletion. This data provides a novel approach for enhancing Chimeric Antigen Receptor T cell efficacy in solid tumors and provides proof of principle for site-directed expression of factors that promote effector T cell differentiation.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"55 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144547643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zincore, an atypical coregulator, binds zinc finger transcription factors to control gene expression","authors":"Daniëlle Bianchi, Razvan Borza, Erica De Zan, Guizela Huelsz-Prince, Sebastian Gregoricchio, Marleen Dekker, Alex Fish, Abdelghani Mazouzi, Lona J. Kroese, Simon Linder, Miguel Hernandez-Quiles, Michiel Vermeulen, Patrick H. N. Celie, Paul Krimpenfort, Ji-Ying Song, Wilbert Zwart, Lodewyk Wessels, Sebastian M. B. Nijman, Anastassis Perrakis, Thijn R. Brummelkamp","doi":"10.1126/science.adv2861","DOIUrl":"https://doi.org/10.1126/science.adv2861","url":null,"abstract":"Zinc finger proteins (ZNFs) are the largest family of transcription factors, yet how they activate gene expression remains unclear. In this study, we identified Zincore, a protein complex consisting of QRICH1 and SEPHS1, as a ZNF-specific coregulator essential for embryonic development in mice and associated with developmental syndromes in humans. We also identified ZFP91 as a representative Zincore client, binding the conserved promoter motif CTTTAAR. Cryo–electron microscopy of a Zincore-ZFP91-DNA complex revealed a SEPHS1 arginine clamp to recognize the DNA-bound zinc finger domains. This mode of binding explains recognition of different ZNFs and stabilizes ZFP91 onto its cognate DNA motif. Thus, our study identified Zincore as a ZNF-specific coregulator essential for development, involving a distinctive mechanism that locks ZNFs onto DNA and regulates transcription.","PeriodicalId":21678,"journal":{"name":"Science","volume":"638 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144547473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluorine-free strongly dipolar polymers exhibit tunable ferroelectricity","authors":"Jiahao Huang, Guanchun Rui, Yueming Yan, Elshad Allahyarov, Man-Hin Kwok, Wenyi Zhu, Li Li, Shixian Zhang, Zhiliang Pan, Deyu Li, Honghu Zhang, Richard R. Mu, Bin Zhao, Qing Wang, Philip L. Taylor, Richard F. Haglund, Q. M. Zhang, Lei Zhu","doi":"10.1126/science.ads4702","DOIUrl":"https://doi.org/10.1126/science.ads4702","url":null,"abstract":"Current research on ferroelectric polymers centers predominantly on poly(vinylidene fluoride) (PVDF)–based fluoropolymers because of their superior performance. However, they are considered “forever chemicals” with environmental concerns. We describe a family of rationally designed fluorine-free ferroelectric polymers, featuring a polyoxypropylene main chain and disulfonyl alkyl side chains with a C3 spacer: −SO <jats:sub>2</jats:sub> CH <jats:sub>2</jats:sub> CHRCH <jats:sub>2</jats:sub> SO <jats:sub>2</jats:sub> − (R = −H or −CH <jats:sub>3</jats:sub> ). Both experimental and simulation results demonstrate that strong dipole-dipole interactions between neighboring disulfonyl groups induce ferroelectric ordering in the condensed state, which can be tailored by changing the R group: ferroelectric for R = −H or relaxor ferroelectric for R = −CH <jats:sub>3</jats:sub> . At low electric fields, the relaxor polymer exhibits electroactuation and electrocaloric performance comparable with those of state-of-the-art PVDF-based tetrapolymers.","PeriodicalId":21678,"journal":{"name":"Science","volume":"236 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144547474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Correction: Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors","authors":"Wei Xia, Jing Xie, Zhiqing Cai, Xuhua Liu, Jing Wen, Zhong-Kai Cui, Run Zhao, Xiaomei Zhou, Jiahui Chen, Xinru Mao, Zhengtao Gu, Zhimin Zou, Zhipeng Zou, Yue Zhang, Ming Zhao, Maegele Mac, Qiancheng Song, Xiaochun Bai","doi":"10.1038/s41467-025-61622-3","DOIUrl":"https://doi.org/10.1038/s41467-025-61622-3","url":null,"abstract":"<p>Correction to: <i>Nature Communications</i> https://doi.org/10.1038/s41467-021-26302-y, published online 15 October 2021</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"20 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144547479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}