综合性期刊最新文献

{"title":"Covalent organic framework membrane with hourglass-shaped nanochannels for ultrafast desalination","authors":"Xiaocui Wei, Yanan Liu, Fu Zhao, Tingyuan Wang, Zongmei Li, Chunyang Fan, Yuhan Yang, Yuhan Wang, Zhongyi Jiang","doi":"10.1038/s41467-025-63650-5","DOIUrl":"https://doi.org/10.1038/s41467-025-63650-5","url":null,"abstract":"<p>Covalent organic framework (COF) holds great potential as next-generation high-performance desalination membrane material owing to their uniform nanochannels (homo-nanochannels) and abundant functional groups, and the hierarchical structures of nanochannels should be rationally designed to break the trade-off between water permeability and ion rejection. Here, a kind of COF membrane with hourglass-shaped nanochannels is fabricated by installing amino-cyclodextrin nanoparticles (CDN) onto the mouth of COF membrane via sequential assembly. The resulting hetero-nanochannels consist of a hydrophilic conical entrance (~1.6 nm) and a hydrophobic spout (~0.5 nm), created by the CDN specific cavity, onto the homo-nanochannels of COF with intrinsic nanopores (~1.4 nm). The hydrophilic conical entrance facilitates the entry of water molecules, whereas the hydrophobic spout and the homo-nanochannels collectively enable fast water transport. Meanwhile, the amino groups on CDN endow the hetero-nanochannels with pH-responsive ability to dynamically regulate their effective size and charge. Accordingly, the optimum COF-CDN membrane exhibits high desalination performance, with a water flux of 98 L m^–2 h^–1, and rejection of 94% for Na₂SO₄ and 92% for NaCl. The COF-CDN membrane also exhibits superior operational stability (7 days) and pH cycle stability, validating the utilization of COF membrane in efficient desalination.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"36 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144919590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single photon γ-ray imaging with high energy and spatial resolution perovskite semiconductor for nuclear medicine","authors":"Nannan Shen, Xuchang He, Tingting Gao, Bao Xiao, Yuquan Wang, Ruohan Ren, Haoming Qin, Khasim Saheb Bayikadi, Zhifu Liu, J. A. Peters, Bruce W. Wessels, Luyao Wang, Xiao Ouyang, Shuquan Wei, Qihao Sun, Xueping Liu, Yifei Lai, Xiaoping Ouyang, Zhifang Chai, Mercouri G. Kanatzidis, Yihui He","doi":"10.1038/s41467-025-63400-7","DOIUrl":"https://doi.org/10.1038/s41467-025-63400-7","url":null,"abstract":"<p>Integrating semiconductor detectors with high energy and spatial resolution is vital for advancing nuclear medicine imaging. Perovskite semiconductors afford unprecedented opportunity for reshaping radiation detection technologies. Nevertheless, perovskite semiconductors have yet to prove their ability in single photon γ-ray imaging, which is essential for enabling nuclear medicine imaging. Herein, we present a pioneering approach to develop high resolution perovskite CsPbBr₃ detectors with pixelated configuration capable of imaging single γ-ray photons for nuclear medicine applications. Eliminating charge transport losses at the surface results in exceptional performance uniformity and long-term device stability, which confers near-unity charge collection efficiency and enhanced spectral resolving capabilities. Record energy resolutions are achieved as 2.5% at 141 keV and 1.0% at 662 keV. Single photon imaging with single point and line ^99mTc γ-ray sources showcases the high sensitivity of 0.13%~0.21% cps/Bq. Phantom imaging distinctly delineates individual column sources spaced 7 mm apart, indicative of an impressive spatial resolution of 3.2 mm. These findings lay the groundwork for integrating perovskite detectors into nuclear medicine γ-ray imaging systems, offering a balance of cost-effectiveness and superior performance.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"85 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144919617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An innovative statistical framework: A simulation study and practical implementations in the dance education, reliability engineering and radiation sector","authors":"Yi Fan Li ,&nbsp;Xinran Xu ,&nbsp;Diaa S. Metwally ,&nbsp;M.M. Abd El-Raouf","doi":"10.1016/j.jrras.2025.101857","DOIUrl":"10.1016/j.jrras.2025.101857","url":null,"abstract":"<div><div>This novel research effort aims to contribute to the literature on probabilistic-oriented methods for illustrating real-world events within different sectors. The new work is based on developing a new distribution family, referred to as the inverted sine Zubair-<span><math><mi>G</mi></math></span> (ISZ-<span><math><mi>G</mi></math></span>) family. The ISZ-<span><math><mi>G</mi></math></span> family is composed of merging the flexibility of the Zubair-<span><math><mi>G</mi></math></span> method with the inverse trigonometric-based method. To illustrate the ISZ-<span><math><mi>G</mi></math></span> in the practical scenarios, we consider the Weibull distribution as its special case, referred to as the inverted sine Zubair–Weibull (ISZ-Weibull) distribution. The mathematical computation of the quantile function of the ISZ-Weibull distribution is carried which are further utilized to compute other mathematical properties. The computation of the point estimators along with the simulation studies are presented. Besides the theoretical work, we also consider the practical implications of the ISZ-Weibull distribution within numerous applied fields such as dance education, reliability engineering and the radiation sector. This is done with the intention to prove the superiority of the ISZ-Weibull distribution over some existing distributions. Based on numerous statistical outlets, we observe that the ISZ-Weibull distribution is a more powerful outlet than certain rival tools available in the literature.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"18 4","pages":"Article 101857"},"PeriodicalIF":2.5,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144916983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge and data-driven two-layer networking for accurate metabolite annotation in untargeted metabolomics","authors":"Haosong Zhang, Xinhao Zeng, Yandong Yin, Zheng-Jiang Zhu","doi":"10.1038/s41467-025-63536-6","DOIUrl":"https://doi.org/10.1038/s41467-025-63536-6","url":null,"abstract":"<p>Metabolite annotation in untargeted metabolomics remains challenging due to the vast structural diversity of metabolites. Network-based approaches have emerged as powerful strategies, particularly for annotating metabolites lacking chemical standards. Here, we develop a two-layer interactive networking topology that integrates data-driven and knowledge-driven networks to enhance metabolite annotation. A comprehensive metabolic reaction network is curated using graph neural network-based prediction of reaction relationships, enhancing both coverage and network connectivity. Experimental data are pre-mapped onto this network via sequential MS1 matching, reaction relationship mapping, and MS2 similarity constraints. The generated networking topology enables interactive annotation propagation with over 10-fold improved computational efficiency. In common biological samples, it annotates over 1600 seed metabolites with chemical standards and &gt;12,000 putatively annotated metabolites through network-based propagation. Notably, two previously uncharacterized endogenous metabolites absent from human metabolome databases have been discovered. Overall, this strategy significantly improves the coverage, accuracy, and efficiency of metabolite annotation and is freely available as MetDNA3.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"1 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144919513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting phagocytosis for amyloid-β clearance: implications of morphology remodeling and microglia activation probed by bifunctional chimaeras","authors":"Youqiao Wang, Zeyi Wang, Ziyi Liu, Jinyan Li, Shuo Yang, Yuxuan Zhao, Yangmei Huang, Chenyang Liao, Yiqiu Zhang, Jiaojiao Zhao, Weilin Zhou, Binhua Zhou, Xin Yue, Qiang Zhou, Xianzhang Bu","doi":"10.1038/s41467-025-63458-3","DOIUrl":"https://doi.org/10.1038/s41467-025-63458-3","url":null,"abstract":"<p>Amyloid-β (Aβ), a key driver of Alzheimer’s disease (AD) pathogenesis, possesses diverse harmful and clearance-resistant structures that present substantial challenges to therapeutic development. Here, we demonstrate that modulating Aβ morphology, rather than Toll-like receptor 2 (TLR2)-dependent microglia activation, is essential for effective phagocytosis of Aβ species by microglia. By developing a bifunctional mechanistic probe (P2CSKn) designed to remodel Aβ and activate TLR2, we show it restructures soluble Aβ (sAβ) and fibrillar Aβ (fAβ) into less toxic hybrid aggregates (hPAβ). Critically, this structural remodeling protects microglia from Aβ toxicity while enabling robust phagocytosis. Moreover, although TLR2 activation mildly enhances Aβ uptake, it concurrently triggers detrimental inflammation that negates its benefits. Our findings establish morphological remodeling as the critical determinant of effective Aβ clearance and suggest a morphology-focused strategy for developing safe therapeutics for Aβ-related diseases.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"09 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144919507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence that mitochondria in macrophages are destroyed by microautophagy","authors":"Shiou-Ling Lu, Siyu Chen, Kazuya Noda, Yangjie Li, Chao-Yuan Tsai, Hiroko Omori, Yumiko Kato, Zidi Zhang, Bohan Chen, Kanako Tokuda, Tongxin Zheng, Masahiro Wakita, Eiji Hara, Mitsunori Fukuda, Yoh Wada, Eiji Morita, Narikazu Uzawa, Shinya Murakami, Takeshi Noda","doi":"10.1038/s41467-025-63531-x","DOIUrl":"https://doi.org/10.1038/s41467-025-63531-x","url":null,"abstract":"<p>Microautophagy is an intracellular degradation process in which degradatory organelles, such as the lysosome, directly take up substrates by invagination and/or protrusion of their membranes. Here, we provide evidence that Rab32-positive, lysosome-related organelles in macrophages incorporate various other organelles, including endosomes and mitochondria. Our data indicates that, upon exposure to a mitochondria-damaging reagent, mitochondria can be directly engulfed by the lysosome-like organelles independently of macroautophagy or ESCRT machinery. Rab32 GTPase, phosphatidylinositol 3,5-bisphosphates, ubiquitination, and p62/SQSTM1 are crucial for this degradation. Furthermore, the degree of M1 polarization of macrophages, which is facilitated by metabolic reprogramming into increased glycolysis via mitochondrial elimination, is significantly reduced in <i>Rab32/38</i> double-knockout macrophages. Thus, microautophagy plays a role in the physiological regulation of macrophages.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"9 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144919510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tailoring bidirectional electronic transfer interaction tunnels triggers sustainable and high activity of ozone catalysis for water purification","authors":"Zilong Song, Jiaguang Xu, Liuqing Zhang, Chun He, Paul Westerhoff, Xin Yang","doi":"10.1038/s41467-025-63614-9","DOIUrl":"https://doi.org/10.1038/s41467-025-63614-9","url":null,"abstract":"<p>Heterogeneous catalytic ozonation shows promise in destroying organic pollutants in water, yet developing catalysts with both high activity and stability remains challenging. In this study, we propose a catalyst design strategy involving the anchoring of electron-sharing sites near single-atom sites to construct bidirectional electron transfer interaction tunnels. The developed catalyst (MnN₃–Fe₁@FeN₄) features Fe₁@FeN₄ atomic clusters as electron-sharing sites, coordinated Mn single-atom centers through shared nitrogen bridges, successfully establishing a synergistic system. The design not only enables rapid electron supply to ozone (i.e., the internal electron transport), reducing electron loss at single atoms through shared electron flow, but also facilitates electron transfer from pollutants to the catalyst via surface reactive species (i.e., the external electron transport), compensating for the electron depletion of active sites. By taking advantage of the dual bidirectional electronic transport interactions tunnels, MnN₃–Fe₁@FeN₄ exhibits an extraordinary catalytic activity towards ozone, achieving over three times higher reactivity than Fe and Mn single atom catalyst and 2–4 orders of magnitude higher reactivity than conventional metal oxides. Moreover, the sustainability of the ozone catalytic activity surpasses almost all of the state-of-the-art catalysts. A catalytic ozone fixed-bed reactor with this catalyst has run continuously for over 260 h, treating 3125 times the bed volume of actual wastewater. Our work unveils a critical role of atomic clusters in modulating catalyst activity and long-term stability in heterogeneous catalytic ozonation, which could inspire innovative material design for more sustainable water purification applications.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"30 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144919515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structure and transport mechanism of the human prostaglandin transporter SLCO2A1","authors":"Zhanyi Xia, Guangyuan Lu, Di Wu, Jun Zhao, Bowen Zhang, Haoran Xu, Yingying Du, Daohua Jiang","doi":"10.1038/s41467-025-63615-8","DOIUrl":"https://doi.org/10.1038/s41467-025-63615-8","url":null,"abstract":"<p>SLCO2A1 is a member of the organic anion transporting polypeptide (OATP) family, which preferentially transports prostaglandins (PGs) into cells and plays a vital role in regulating PGs inactivation and distribution. Dysregulation or genetic mutation of SLCO2A1 is associated with primary hypertrophic osteoarthropathy (PHO) and chronic enteropathy associated with the <i>SLCO2A1</i> gene (CEAS). Although the biophysical and biochemical properties of SLCO2A1 have been characterized, the precise mechanism by which SLCO2A1 recognizes and transports PGs remains unclear. Here, we present the cryo-electron microscopy structures of human SLCO2A1 in apo and PGE₂-bound forms, revealing the detailed structural features and structural basis for PGs transport. Fatty acid-like PGE₂ binds in the central cavity, engaging in specific interactions with W565 and two serine residues, which are not conserved in other OATPs. Combined with functional assays and structural comparisons, this study offers mechanistic insights into PGE₂ recognition, substrate selectivity, conformational changes, and pathology of SLCO2A1.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"19 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144919593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomimetic microstructure design for ultrasensitive piezoionic mechanoreceptors in multimodal object recognition","authors":"Mingqi Ding, Pengshan Xie, Jingwen Wang, Wu Guo, Haifan Li, Siliang Hu, Dengji Li, Bowen Li, Nan Wang, Chun-Yuen Wong, Jia Sun, Johnny C. Ho","doi":"10.1038/s41467-025-63115-9","DOIUrl":"https://doi.org/10.1038/s41467-025-63115-9","url":null,"abstract":"<p>The challenge of achieving high recognition accuracy in artificial mechanoreceptors arises from the trade-off between sensitivity and stability in the sensing unit. Inspired by human skin, we developed a biomimetic approach that involves structural and engineering enhancements for ionic-conducting polyvinyl alcohol/Ti₃C₂T_x (PVA/MXene) composite hydrogel microneedles (HM) to enhance the sensitivity. By integrating the HM with a polyethylene terephthalate/indium tin oxide (PET/ITO) film, we create a non-faradaic junction that ensures stable electrical output without transmission loss under stimulation. Furthermore, the significant alteration in nanosheet spacing facilitates proton transport along the MXene microchannels, increasing the plasmonic gradient between the junction and the hydrogel’s center, thereby boosting piezoionic efficiency. Consequently, the biomimetic sensing unit achieves a high power density of 165.6 mW m^-2 and exceptional sensing stability over 10,000 cycles. When combined with vertical memristor units, this system effectively captures and transforms characteristic signals from various objects, achieving a recognition accuracy of 90%.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"51 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144919241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metformin alters mitochondria-related metabolism and enhances human oligodendrocyte function","authors":"Nina-Lydia Kazakou, Nadine Bestard-Cuche, Laura J. Wagstaff, Kellie Horan, Luise Seeker, Sunniva Bøstrand, Rana Fetit, Rebecca Sherrard Smith, Fabio Baldivia Pohl, Bjorn Neumann, Patrick Keeler, Robin J. M. Franklin, Anna Williams","doi":"10.1038/s41467-025-63279-4","DOIUrl":"https://doi.org/10.1038/s41467-025-63279-4","url":null,"abstract":"<p>Metformin rejuvenates adult rat oligodendrocyte progenitor cells (OPCs) allowing more efficient differentiation into oligodendrocytes and improved remyelination, and therefore is of interest as a therapeutic in demyelinating diseases such as multiple sclerosis (MS). Here, we test whether metformin has a similar effect in human stem cell derived-OPCs. We assess how well human monoculture, organoid and chimera model culture systems simulate in vivo adult human oligodendrocytes, finding most close resemblance in the chimera model. Metformin increases myelin proteins and/or sheaths in all models even when human cells remain fetal-like. In the chimera model, metformin leads to increased mitochondrial area both in the human transplanted cells and in the mouse axons with associated increase of mitochondrial function/metabolism transcripts. Human oligodendrocytes from MS brain donors treated pre-mortem with metformin also express similar transcripts. Metformin’s brain effect is thus not cell-specific, alters metabolism in part through mitochondrial changes and leads to more myelin production. This bodes well for clinical trials testing metformin for neuroprotection.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"13 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144919508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}