Annals of the New York Academy of Sciences最新文献

The Role of Estrogen and Its Receptors in Brain Development and Their Long-Term Effects 雌激素及其受体在脑发育中的作用及其长期影响。

IF 4.5 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2026-11-05 DOI: 10.1111/nyas.70442

Xuan Xia, Xiaoxiang Sun, Kaiqi Chen, Yawen Chen

{"title":"The Role of Estrogen and Its Receptors in Brain Development and Their Long-Term Effects","authors":"Xuan Xia, Xiaoxiang Sun, Kaiqi Chen, Yawen Chen","doi":"10.1111/nyas.70442","DOIUrl":"10.1111/nyas.70442","url":null,"abstract":"<div>\u0000 \u0000 <p>Estrogens are a class of steroid hormones that participate not only in reproduction and sexual differentiation but also in brain development. The major endogenous estrogens include estrone (E1), 17β-estradiol (E2), and estriol (E3), whose relative abundance and biological sources vary across sex and life stage. During fetal and early postnatal development, estrogenic signaling is sensitive to both intrinsic physiological conditions and extrinsic environmental factors. Through estrogen receptor (ER)-mediated signaling, endogenous estrogens regulate neuronal migration, differentiation, and synaptic plasticity, thereby influencing brain morphology, functional development, and sexual differentiation. Dysregulated estrogen signaling may alter the development of sexually differentiated brain regions and thereby contribute to sex-related differences in brain function and disease vulnerability. This review summarizes the distribution and expression patterns of estrogen and its receptors in the brain, elucidates the role of endogenous estrogen and ERs in neurodevelopment, and examines the impact of exogenous estrogenic and endocrine-disrupting exposures on brain maturation. Together, these findings provide a framework for understanding how estrogen signaling contributes to neurodevelopment and its long-term outcomes.</p>\u0000 </div>","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1565 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149340428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Six-Month Music Practice Versus Psychomotor Interventions in Mild Cognitive Impairment: Behavioral and Hippocampal Outcomes 六个月的音乐练习与精神运动干预对轻度认知障碍的影响：行为和海马的结果

IF 4.5 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2026-11-02 DOI: 10.1111/nyas.70433

Clara E. James, Chantal Junker-Tschopp, Matthias Kliegel, Dimitra Kokkinou, Gilles Allali, Giovanni B. Frisoni, Andrea Brioschi Guevara, Damien Marie

{"title":"Six-Month Music Practice Versus Psychomotor Interventions in Mild Cognitive Impairment: Behavioral and Hippocampal Outcomes","authors":"Clara E. James, Chantal Junker-Tschopp, Matthias Kliegel, Dimitra Kokkinou, Gilles Allali, Giovanni B. Frisoni, Andrea Brioschi Guevara, Damien Marie","doi":"10.1111/nyas.70433","DOIUrl":"10.1111/nyas.70433","url":null,"abstract":"<p>Mild cognitive impairment (MCI) is characterized by measurable cognitive decline with largely preserved daily functioning and increased risk of dementia. MCI patients may also exhibit sensorimotor and communication impairments, while hippocampal atrophy and altered functional connectivity are prominent neural features associated with further cognitive decline. Evidence from nonpharmacological interventions integrating cognitive challenge, coordinated movement, and emotional engagement remains limited in early-stage MCI. In this pilot intervention study, we examined whether 6 months of intensive musical instrument training versus psychomotor interventions were associated with changes in cognitive and sensorimotor performance, hippocampal gray matter volume, and functional connectivity. Outcomes were compared between randomized MCI groups, with matched healthy controls as reference for test−retest and age-related neural effects. Improvements in global cognition were modest, reaching marginal significance only in the music group, while both interventions were associated with complementary domain-specific cognitive and sensorimotor gains. Hippocampal gray matter volume remained stable across all three groups, whereas hippocampal functional connectivity declined in healthy controls but remained stable in both intervention groups, consistent with possible functional neural maintenance. These preliminary findings suggest that group-based, low-risk music and psychomotor interventions may support cognitive, sensorimotor, and neural functioning in early MCI, warranting further investigation in larger controlled trials.</p>","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1565 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/nyas.70433","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149304566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating and Optimizing Mass Decarceration as a Pandemic Mitigation Strategy 评估和优化大规模疏散作为大流行缓解策略

IF 4.5 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2026-11-02 DOI: 10.1111/nyas.70434

Rayan Succar, Lorenzo Zino, Diana Silver, Anna Harvey, Maurizio Porfiri

{"title":"Evaluating and Optimizing Mass Decarceration as a Pandemic Mitigation Strategy","authors":"Rayan Succar, Lorenzo Zino, Diana Silver, Anna Harvey, Maurizio Porfiri","doi":"10.1111/nyas.70434","DOIUrl":"10.1111/nyas.70434","url":null,"abstract":"<div>\u0000 \u0000 <p>The COVID-19 pandemic exposed the vulnerabilities of carceral systems as high-risk environments for disease transmission. In response, jurisdictions across the United States implemented mass decarceration policies aimed at reducing jail populations. This paper investigates such interventions and their optimal planning, leveraging system-theoretic insights. First, we empirically demonstrate the influence of jail population changes on COVID-19 infections by applying convergent cross mapping, transfer entropy, and linear regression to real-world data. We find that the jail population dynamics were associated with the evolution of the pandemic. Building on this empirical finding, we present a compartmental epidemiological model that captures the coupled dynamics of disease spread in jails and their surrounding communities, with fluxes modeled as time-dependent control inputs. Using optimal control theory, we derive an optimal design for these fluxes to balance public health and public safety. Our findings provide both empirical and model-informed evidence that mass decarceration was not only a reactive policy choice but also a justifiable intervention for pandemic mitigation. We emphasize that our optimization is carried out within the space of admission and release policies and does not rank decarceration against other public-health measures.</p></div>","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1565 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149305070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Large Language Model Framework for Seed Implant Brachytherapy: Adaptive Weight Optimization via Retrieval-Augmented Generation 种子植入近距离治疗的大型语言模型框架：通过检索增强生成的自适应权重优化

IF 4.5 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2026-10-30 DOI: 10.1111/nyas.70448

Zhuo Xiao, Qinglong Yao, Jingjing Wang, Bo Liu, Fugen Zhou, Haitao Sun, Zhe Ji, Yuliang Jiang, Junjie Wang, Qiuwen Wu

{"title":"A Large Language Model Framework for Seed Implant Brachytherapy: Adaptive Weight Optimization via Retrieval-Augmented Generation","authors":"Zhuo Xiao, Qinglong Yao, Jingjing Wang, Bo Liu, Fugen Zhou, Haitao Sun, Zhe Ji, Yuliang Jiang, Junjie Wang, Qiuwen Wu","doi":"10.1111/nyas.70448","DOIUrl":"10.1111/nyas.70448","url":null,"abstract":"<div>\u0000 \u0000 <p>Seed implant brachytherapy (SIBT) is an effective cancer treatment modality; however, clinical planning often relies on manual adjustment of objective function weights, leading to inefficiencies and suboptimal results. This study proposes an adaptive weight optimization framework for SIBT planning, driven by large language models (LLMs). A locally deployed DeepSeek-R1 LLM is integrated with an automatic planning algorithm in an iterative loop. Starting with fixed weights, the LLM evaluates plan quality and recommends new weights in the next iteration. This process continues until convergence criteria are met, after which the LLM conducts a comprehensive evaluation to identify the optimal plan. A clinical knowledge base, constructed and queried via retrieval-augmented generation (RAG), enhances the model's domain-specific reasoning. The proposed method was retrospectively validated on 23 patient cases who underwent head-and-neck SIBT, showing that the LLM-assisted approach maintained clinical target volume (CTV) coverage and reduced excessive target dose relative to fixed-weight planning; in the eight patients with available organs at risk (OARs) contours, OAR dose metrics showed favorable numerical trends. The study demonstrates the potential of LLMs as assistive tools for SIBT planning under clinician supervision.</p>\u0000 </div>","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1565 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149292825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Respirasome Persistence Without Efficient Electron Channeling in Cardiac Mitochondria From an Animal Model of Hypertension 高血压动物模型心脏线粒体中无有效电子通道的呼吸小体持久性

IF 4.5 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2026-10-30 DOI: 10.1111/nyas.70440

Patrycja Anna Glogowski, Cristina Algieri, Antonia Cugliari, Maria Cotugno, Fabiana Trombetti, Micaela Fabbri, Arrigo Francesco Giuseppe Cicero, Speranza Rubattu, Salvatore Nesci

{"title":"Respirasome Persistence Without Efficient Electron Channeling in Cardiac Mitochondria From an Animal Model of Hypertension","authors":"Patrycja Anna Glogowski, Cristina Algieri, Antonia Cugliari, Maria Cotugno, Fabiana Trombetti, Micaela Fabbri, Arrigo Francesco Giuseppe Cicero, Speranza Rubattu, Salvatore Nesci","doi":"10.1111/nyas.70440","DOIUrl":"10.1111/nyas.70440","url":null,"abstract":"<p>Cardiac mitochondrial dysfunction contributes to hypertensive remodeling, but whether respiratory supercomplex organization preserves electron transfer efficiency during disease progression remains unresolved. Here, we examined the structural and functional organization of the respiratory complexes in cardiac mitochondria from stroke-resistant and stroke-prone spontaneously hypertensive rats exposed to normal or Japanese diet regimens. In both models, supramolecular analyses revealed the persistence of N-respirasome and Q-respirasome assemblies, indicating that major respiratory supercomplex species are maintained during sustained hypertension and in the pre-stroke state. However, metabolic flux control analysis consistently showed that cytochrome <i>c</i> oxidase or Complex IV exerted only limited control over respiratory flux, with control coefficients below those expected for tightly channeled nicotinamide adenine dinucleotide (NADH)-dependent electron transfer. Thus, structural preservation of respirasomes was not matched by evidence of kinetically optimized coupling. These findings uncouple supercomplex detectability from functional electron channeling and suggest that, in the hypertensive heart, respiratory performance is constrained by qualitative defects in supercomplex organization rather than by their overt loss.</p>","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1565 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/nyas.70440","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149292826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

No Silver Bullet for Rhythm Analysis 节奏分析没有灵丹妙药

IF 4.5 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2026-10-30 DOI: 10.1111/nyas.70443

Yannick Jadoul, Jelle van der Werff, Dunia Giomo

引用次数: 0

Re-Emergence of Thiamine Deficiency Among Pregnant and Lactating Women in Northeast India 印度东北部孕妇和哺乳期妇女中硫胺素缺乏症的再次出现

IF 4.5 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2026-10-30 DOI: 10.1111/nyas.70431

Mahesh Kumar Mummadi, Roshine Koshy, Esther Thejo Rajitha, Samarasimha Reddy N., Raghavendra Pandurangi, Sreenu Pagidoju, Venkata Raji Reddy, Harichandana Ponnapalli, Karthikeyan Ramanujam, Satish Motapalukula, Keerthana Gajjala, Shankar Sapavat, Starlin Vijay Mythri, Chandan Nalli, Olivia Mazumder, Sylvia Fernandez Rao, SubbaRao M. Gavaravarapu, Rajender Rao Kalashikam, J. J. Babu Geddam, Filomena Gomes, Megan W. Bourassa

{"title":"Re-Emergence of Thiamine Deficiency Among Pregnant and Lactating Women in Northeast India","authors":"Mahesh Kumar Mummadi, Roshine Koshy, Esther Thejo Rajitha, Samarasimha Reddy N., Raghavendra Pandurangi, Sreenu Pagidoju, Venkata Raji Reddy, Harichandana Ponnapalli, Karthikeyan Ramanujam, Satish Motapalukula, Keerthana Gajjala, Shankar Sapavat, Starlin Vijay Mythri, Chandan Nalli, Olivia Mazumder, Sylvia Fernandez Rao, SubbaRao M. Gavaravarapu, Rajender Rao Kalashikam, J. J. Babu Geddam, Filomena Gomes, Megan W. Bourassa","doi":"10.1111/nyas.70431","DOIUrl":"10.1111/nyas.70431","url":null,"abstract":"<div>\u0000 \u0000 <p>Thiamine (vitamin B1) deficiency, once considered controlled in India, has re-emerged in parts of Northeast India, raising concern for maternal and infant health. We conducted a community-based cross-sectional study during 2023–2024 to estimate its prevalence and dietary determinants among pregnant and lactating women in the Barak Valley of Assam and adjoining districts of Tripura. Using multistage cluster sampling, women were recruited from 120 villages with documented beriberi clusters. Thiamine status was assessed by determining the erythrocyte transketolase activation coefficient (ETKAC), a functional marker, and whole-blood thiamine diphosphate (ThDP), a biochemical marker measured by high-performance liquid chromatography. Of 1329 women, 1083 were analyzed. Both markers gave similar estimates of suboptimal status: 20.1% by ThDP (95% CI: 17.8−22.6; deficient: 4.9%, marginal: 15.2%) and 20.6% by ETKAC (95% CI: 18.3−23.1; severe: 8.5%, marginal: 12.1%), higher among pregnant than lactating women. Diets were rice-based with low diversity. As the functional marker ETKAC was more sensitive to dietary context, we focused on its determinants: stored rice, washing rice repeatedly before cooking, and drinking salted tea were each associated with higher odds of ETKAC-defined suboptimal status. Socioeconomic disadvantage further increased risk. This substantial, subclinical, preventable burden driven by dietary monotony and thiamine-depleting rice practices underscores the need for targeted maternal nutrition strategies.</p>\u0000 </div>","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1565 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149292889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time Flows With the Changing of Events 时间随着事件的变化而流逝

IF 4.5 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2026-10-29 DOI: 10.1111/nyas.70446

Matthew Logie, Marianna Lamprou-Kokolaki, Virginie van Wassenhove

{"title":"Time Flows With the Changing of Events","authors":"Matthew Logie, Marianna Lamprou-Kokolaki, Virginie van Wassenhove","doi":"10.1111/nyas.70446","DOIUrl":"10.1111/nyas.70446","url":null,"abstract":"<p>In recent years, investigations into the psychological experience of time have rapidly accelerated. The experience of time could depend on a ticking internal clock or rely on contextual changes within and between events. Cognitive theories of memory propose that the presence of event boundaries, as defined by unexpected changes, is crucial for the segmentation of sequenced content and ultimately, the formation of long-term memories. Interestingly, the experience of change also influences the temporal distances between memories. Concurrent lines of research have developed similar theories on the experience of time, with salient contextual changes distorting temporal experience. Herein, we propose a unification of theories from the fields of time and memory. Events are creatively constructed and encoded into long-term memory if sufficient changes occur. The subjective experience of time is also determined by an accumulation of changes creating temporal distances between memories. The encoding of memories provides temporal tags at multiple nested timescales, with no need to synchronize with the relative number of seconds that have passed, and duration estimates require a reconstruction of information between anchor points. Time does not exist without change, and experiencing change is fundamental for the formation of lasting memories.</p>","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1565 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/nyas.70446","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149281832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Levodopa and Subthalamic Nucleus Deep Brain Stimulation Modulate Excitation/Inhibition Balance and the Neural Encoding of Isochronous Sequences in Persons With Parkinson's Disease 左旋多巴和丘脑底核深部脑刺激调节帕金森病患者的兴奋/抑制平衡和等时序列的神经编码

IF 4.5 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2026-10-29 DOI: 10.1111/nyas.70430

Antonio Criscuolo, Michael Schwartze, Johannes Schwarz, Karl Strecker, Swen Hesse, Sonja A. Kotz

{"title":"Levodopa and Subthalamic Nucleus Deep Brain Stimulation Modulate Excitation/Inhibition Balance and the Neural Encoding of Isochronous Sequences in Persons With Parkinson's Disease","authors":"Antonio Criscuolo, Michael Schwartze, Johannes Schwarz, Karl Strecker, Swen Hesse, Sonja A. Kotz","doi":"10.1111/nyas.70430","DOIUrl":"10.1111/nyas.70430","url":null,"abstract":"<p>Temporally regular auditory stimuli, as found in isochronous sound streams, metronome beats, or music, are often used in rhythmic auditory stimulation (RAS) interventions to initiate and stabilize the temporal coordination of motor plans in persons with Parkinson's disease (pwPD). Research suggests that RAS promotes the recruitment of a cerebellar-prefrontal network and recalibrates abnormal β-band synchronization in the striato–thalamo–cortical pathway. These cuing effects can resemble those observed via dopaminergic treatments (e.g., levodopa) and deep brain stimulation (DBS) targeting the subthalamic nucleus (STN). Here, we investigated the influence of both levodopa administration and STN DBS on the neural encoding of isochronous auditory sequences in pwPD. A comprehensive analysis of electroencephalography (EEG) data revealed changes in β-band event-locked neural responses, as well as event-related potentials, neural tracking of rhythm (δ-band inter-trial phase coherence), and excitation/inhibition balance (E/I) as a function of these treatments. Furthermore, we characterized the link between changes in E/I and motor symptom severity (UPDRS-III) with levodopa administration. We suggest that characterizing individual responses to specific treatments is a fundamental step in tailoring rehabilitation protocols and optimizing intervention efficacy.</p>","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1565 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/nyas.70430","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149281281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bidirectional Interaction Between Clock Genes and Reactive Oxygen Species Production in Carp and Zebrafish Macrophages 时钟基因与鲤鱼和斑马鱼巨噬细胞活性氧产生的双向相互作用

IF 5.2 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2026-10-26 DOI: 10.1111/nyas.70419

Mikolaj Mazur, Zaneta Baran, Katarzyna Klak, Magdalena Maciuszek, Maria Zawisza, Kinga Rarata, Magdalena Widziolek, Magdalena Chadzinska

{"title":"Bidirectional Interaction Between Clock Genes and Reactive Oxygen Species Production in Carp and Zebrafish Macrophages","authors":"Mikolaj Mazur, Zaneta Baran, Katarzyna Klak, Magdalena Maciuszek, Maria Zawisza, Kinga Rarata, Magdalena Widziolek, Magdalena Chadzinska","doi":"10.1111/nyas.70419","DOIUrl":"https://doi.org/10.1111/nyas.70419","url":null,"abstract":"Our study investigated the bidirectional interaction between circadian clock genes and reactive oxygen species (ROS) production in fish monocytes/macrophages (Mo/Mf). Macrophages are key leukocytes whose antimicrobial activity relies on ROS generation. As ROS levels fluctuate across the day and clock genes regulate numerous cellular processes, we examined whether macrophage clock gene activity and ROS production are functionally interconnected. We found that carp Mo/Mf displayed constitutive expression of core clock genes and genes involved in melatonin synthesis and redox balance: Clock genes ( per2 , clock , cry2 , and bmal2 ) showed rhythmic expression under both light:dark and constant dark conditions and ROS production varied across the day. Ex vivo cell stimulation revealed that immune signals, cortisol, and ROS‑modulating agents altered clock gene expression. Direct ROS donors upregulated multiple clock genes, while inhibition of NADPH oxidase reduced ROS production and changed expression of clock genes. Finally, zebrafish mutants lacking cry1 exhibited changes in ROS production, demonstrating that disruption of the circadian clock affects redox activity. Together, these findings show that carp and zebrafish Mo/Mf possess a functional circadian system and that the ROS and clock pathways influence each other. This interplay may shape daily patterns of immune responsiveness and contribute to time‑dependent variation in host defense.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"6 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149251302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0