Lin Chen,Dong Yang,Wanlin Wang,Hongyun Xing,Xianglong Bian,Hua Pei,Qianfeng Xia,Tingwei Hu,Penghui Li,Paul K Chu
{"title":"Three-Dimensional Ribbon-Like Gold Nanoparticle Assemblies on MXene for Detection of Creatinine by Surface-Enhanced Raman Scattering.","authors":"Lin Chen,Dong Yang,Wanlin Wang,Hongyun Xing,Xianglong Bian,Hua Pei,Qianfeng Xia,Tingwei Hu,Penghui Li,Paul K Chu","doi":"10.1111/nyas.70097","DOIUrl":"https://doi.org/10.1111/nyas.70097","url":null,"abstract":"Creatinine is an important indicator of renal function, and its accurate and efficient detection is important to clinical diagnosis and disease monitoring. As the structure combining MXene layers and gold nanoparticles (AuNPs) provides many active sites and hot spots for surface-enhanced Raman scattering (SERS), ultrasensitive detection of creatinine can be realized. Herein, homogeneous ultrathin Ti3C2-MXene films are produced on a large scale by interfacial self-assembly, and a uniformly distributed AuNP monolayer and three-dimensional ribbon-like AuNP assemblies (RAuNPs) are then separately assembled on the MXene surface by simply regulating the nanoparticle concentration and the drying temperature. The two SERS substrates of AuNPs/MXene and RAuNPs/MXene are capable of sensitive detection of creatinine in aqueous solutions without labels. The SERS activity is verified using Rhodamine 6G (R6G). In the SERS detection of creatinine, the AuNPs/MXene substrate shows a linear range from 1 × 10-4 to 1 × 10-8 M with a limit of detection (LOD) of 287 nM, whereas the RAuNPs/MXene substrate exhibits a good linear relationship in the range from 1 × 10-3 to 1 × 10-10 M with a LOD of 2.64 nM. The outstanding SERS properties of RAuNPs/MXene suggest promising potential pertaining to the rapid and sensitive detection of creatinine.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"8 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145229082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yessenia Chavez, Hongdao Meng, Yujun Liu, Jamie Mayer, Nathan Campbell, Christopher Wright, Alex Amidei, Insha Butail, Sydney Fields, Makenna Green, Layla Katharine Santana, Chloe Steffel, Angela J. Grippo
{"title":"Effects of classical music on behavioral stress reactivity in socially isolated prairie voles","authors":"Yessenia Chavez, Hongdao Meng, Yujun Liu, Jamie Mayer, Nathan Campbell, Christopher Wright, Alex Amidei, Insha Butail, Sydney Fields, Makenna Green, Layla Katharine Santana, Chloe Steffel, Angela J. Grippo","doi":"10.1111/nyas.70044","DOIUrl":"https://doi.org/10.1111/nyas.70044","url":null,"abstract":"Social stressors negatively influence behaviors and neurobiological functioning in humans and animal models. Listening to music has been shown to improve behavior, cognition, and emotion. However, the interactions of social stress, behavior, and listening to music, as well as potential sex differences, remain less understood. This study investigated the potential protective behavioral effects of classical music exposure in socially monogamous prairie voles. After confirming that prairie voles can hear and display observable behavioral responses to music, socially isolated prairie voles (vs. paired) were exposed to a short‐term open field stressor during the presentation of piano or violin music, compared to ambient noise. Exposure to both types of music (vs. ambient noise) altered anxiety‐like behaviors and behavioral stress reactivity, with minor sex differences observed. The influence of music on behaviors in the open field was specific to isolated prairie voles, as music did not alter behaviors in paired animals. This research demonstrates that, when social contact is limited or unavailable, exposure to music may improve behavioral responses to a short‐term stressor. Continued investigation into the beneficial effects of music in social rodent models will enhance our understanding of the protective influence of music in humans who experience social stress.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"12 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Justin Malogan, Haley Anne Hallowell, Brianna Francis, Jotham Suez
{"title":"Supplementation and Elimination of Microbiome‐Produced Metabolites in the Treatment of Human Disease","authors":"Justin Malogan, Haley Anne Hallowell, Brianna Francis, Jotham Suez","doi":"10.1111/nyas.70103","DOIUrl":"https://doi.org/10.1111/nyas.70103","url":null,"abstract":"The human gut microbiome has a complex and influential relationship with host physiology that is governed through commensal‐derived metabolites, small molecules, and endogenous microbial patterns. Indeed, microbial metabolites from the gut microbiome have been implicated in promoting health as well as contributing to the pathogenesis of microbiome‐associated diseases. Live microbial therapeutics, such as probiotics and fecal microbiota transplantations, have been extensively utilized to establish health‐promoting assemblages of bacteria and their associated beneficial metabolites. However, broad clinical use of live microbial therapeutics is limited by efficacy, specificity, and safety concerns. To circumvent this, a postbiotic approach can be taken, in which a beneficial effect may be achieved by direct administration of bacterially derived bioactive molecules. Alternatively, in cases where microbiome‐derived metabolites drive disease, specific oral inhibitors can be used to restrict compound production. In this review, we examine the use of postbiotics to alleviate disease and highlight recent translational successes. Additionally, we discuss emerging approaches for precision elimination of disease‐causing metabolites, as well as the exciting possibility of utilizing bacteriophages to modulate the production of metabolites in the microbiome.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"105 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mingkun Guo, Jie Zhang, Hongxing Liu, Yanru Bai, Guangjian Ni
{"title":"Signal-to-Noise Ratio Effects Frontoparietal Network Lateralization: Electroencephalogram Evidence in Underwater Auditory Target Recognition","authors":"Mingkun Guo, Jie Zhang, Hongxing Liu, Yanru Bai, Guangjian Ni","doi":"10.1111/nyas.70081","DOIUrl":"https://doi.org/10.1111/nyas.70081","url":null,"abstract":"Accurately recognizing auditory targets within background interference remains challenging at a low signal-to-noise ratio (SNR). Using an oddball paradigm, this electroencephalogram study investigated the impact of SNR (0, −10, and −20 dB) on psychophysiological processes underlying underwater auditory target recognition in twenty normal-hearing participants. Reduced SNR impaired the N1–P2 component and led to P300 variations, with delayed latencies (N1: <i>p</i> = 0.0355; P300: <i>p</i> = 0.0075) and reduced amplitudes (P2: <i>p</i> = 0.0075; P300: <i>p</i> = 0.0277), indicating increased attentional demands. Microstate analysis highlighted 300–400 ms frontoparietal activation for attention orientation and sensory information integration. Reduced accuracy correlates with alpha-band activity and phase variations over frontoparietal areas (event-related spectral perturbation [ERSP]: <i>p</i> = 0.0388; inter-trial coherence [ITC]: <i>p</i> = 0.0059), implying suppression of task-relevant processing. Gamma-band activity and phase at lower SNR levels suggest changes in the parietal network's function (ERSP: <i>p</i> = 0.0183; ITC: <i>p</i> = 0.0113), influencing reaction times due to increased integration difficulty. Right-lateralized alpha- and gamma-band network shifts support the functional advantages of the right hemisphere in noise, with enhanced local efficiency (frontal alpha: <i>p</i> = 0.0100; parietal—occipital gamma: <i>p</i> = 0.0116). These findings provide insights into the psychophysiological mechanisms underlying auditory target recognition in noise.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"54 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145209907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Qiang Wang, Shihao Li, Hongzan Sun, Shulin Cui, Weibo Song
{"title":"A Multimodal Classification Method for Nasal Obstruction Severity Based on Computed Tomography and Nasal Resistance","authors":"Qiang Wang, Shihao Li, Hongzan Sun, Shulin Cui, Weibo Song","doi":"10.1111/nyas.70085","DOIUrl":"https://doi.org/10.1111/nyas.70085","url":null,"abstract":"The assessment of the degree of nasal obstruction is valuable in disease diagnosis, quality of life assessment, and epidemiological studies. To this end, this article proposes a multimodal nasal obstruction degree classification model based on cone beam computed tomography (CBCT) images and nasal resistance measurements. The model consists of four modules: image feature extraction, table feature extraction, feature fusion, and classification. In the image feature extraction module, this article proposes a strategy of using the trained MedicalNet large model to get the pre‐training parameters and then migrating them to the three‐dimensional convolutional neural network (3D CNN) feature extraction model. For the nasal resistance measurement form data, a method based on extreme gradient boosting (XGBoost) feature importance analysis is proposed to filter key features to reduce the data dimension. In order to fuse the two types of modal data, a feature fusion method based on local and global features was designed. Finally, the fused features are classified using the tabular network (TabNet) model. In order to verify the effectiveness of the proposed method, comparison experiments and ablation experiments are designed, and the experimental results show that the accuracy and recall of the proposed multimodal classification model reach 0.93 and 0.9, respectively, which are significantly higher than other methods.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"37 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Colleen E. Sullivan, Karey L. O'Hara, Jessica M. Salerno, Stacia N. Stolzenberg
{"title":"Parent Conflict, Accused Parent, and Sexism Beliefs Influence Credibility in Parent‐Accused Child Sexual Abuse Cases","authors":"Colleen E. Sullivan, Karey L. O'Hara, Jessica M. Salerno, Stacia N. Stolzenberg","doi":"10.1111/nyas.70100","DOIUrl":"https://doi.org/10.1111/nyas.70100","url":null,"abstract":"When parent‐accused child sexual abuse allegations co‐occur with parent conflict, concerns arise that the allegations are fabricated by the child's non‐accused parent. However, no prior research has directly examined how parent conflict influenced credibility in parent‐accused child sexual abuse cases. There are also discrepant research findings on how accused parent gender and decision‐makers’ gender‐based beliefs influenced allegation credibility in parent‐accused abuse and conflict cases. We examined how parent conflict (low, high), accused parent (father, mother, mother's boyfriend), and participants’ belief in sexism shift (BSS) (belief that men are now the primary targets of sexism) influenced allegation credibility. High parent conflict significantly reduced allegation credibility and did not significantly interact with the accused parent or participants’ BSS. Allegations against the mother were rated least credible, followed by the father, and allegations against the mother's boyfriend were rated most credible. This, however, was moderated by participants’ BSS: those with high endorsement of BSS rated allegations against the father as least credible. Legal professionals working with parent‐accused child sexual abuse cases should critically consider how parent conflict, the accused parent, and their gender‐based beliefs influence their decisions in ways that are not grounded in the facts of the case.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"26 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Genetic Diversification of Crimean‐Congo Hemorrhagic Fever Virus Lineage Europe 1","authors":"Yan Li","doi":"10.1111/nyas.70059","DOIUrl":"https://doi.org/10.1111/nyas.70059","url":null,"abstract":"Crimean‐Congo hemorrhagic fever (CCHF) is prevalent in Africa, Asia, and Europe and poses a serious and long‐standing public health burden. Europe, especially Russia, Turkey, and the Balkan region, has been a hotspot for the disease, with the most confirmed reports. Crimean‐Congo hemorrhagic fever virus (CCHFV), the etiological agent of the disease, shows general delineation of phylogeography among the CCHF‐epidemic areas. The isolates of lineage Europe 1 represent the majority of the agent in Europe and primarily circulate in the Russia–Turkey–Balkan region. To decipher the molecular basis of the CCHF epidemicity in Europe, I analyzed the genetic diversification of lineage Europe 1 isolates. Contingency analysis with the reconstructed ancestral sequences of the large (L) and medium (M) segments showed that, in the early epidemic of the lineage, rapid diversification occurred in the nonstructural M protein of the M segment. The McDonald−Kreitman test, together with contingency analysis, showed that nucleoprotein of the small (S) segment achieved an acceleration of amino acid substitutions in this process. These findings offer a molecular perspective on CCHFV epidemicity, at least in Europe, and highlight the key viral factors that could have contributed to the emergence of lineage Europe 1.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"86 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Decoding Cross‐Modal Haptic Neural Coupling Through EEG‐LSTM Spatiotemporal Modeling for Vibration−Roughness Interaction","authors":"Zhikai Li, Weixing Wang, Hongwei Li, Qiao Hu","doi":"10.1111/nyas.70067","DOIUrl":"https://doi.org/10.1111/nyas.70067","url":null,"abstract":"Haptic feedback is crucial for enhancing virtual immersion, but a neural coding mechanism that correlates the vibration frequency with surface roughness in haptic substitution remains unknown, which hinders the development of tribologically driven haptic interfaces. To address this limitation, this study models cross‐modal neural coupling between mechanical vibrations and roughness systematically through double‐blind experiments, event‐related potential analysis, and electroencephalography (EEG) space−time modeling based on the long short‐term memory (LSTM) method. By dynamically extracting the spatiotemporal dependence of the EEG signals by the LSTM method and quantifying neural representation similarity using Euclidean distances, this study reveals that cortical responses activated by specific vibration frequencies are highly consistent with natural roughness perception. In addition, the results of the behavioral verification confirm neurobehavioral consistency in perceptual equivalence. The results also show that vibration‐touch substitution can simulate roughness perception through frequency‐tuned neural coding. Further, this study proposes a cortical response‐aligned haptic framework that provides a theoretical paradigm for virtual reality and teleoperation applications, thus advancing tribological cross‐modal neural engineering.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"12 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Moment Versus a Lifetime: Patterns of Loneliness and Perceived Causes in People's Lived Experiences","authors":"Luzia Cassis Heu","doi":"10.1111/nyas.70082","DOIUrl":"https://doi.org/10.1111/nyas.70082","url":null,"abstract":"For effective loneliness interventions, we need a better understanding of why some loneliness experiences persist (often labeled chronic loneliness), while most loneliness experiences remain transient. To provide starting points for future research on causes of chronic loneliness, interview data from adults ages 19–45 years from India, Egypt, Turkey, Israel, Bulgaria, and Austria were reanalyzed. Because of little scientific consensus on the exact definition of chronic versus transient loneliness, different temporal patterns of loneliness were first distinguished in the data. Instead of two, four types emerged: Transient loneliness typically lasted some hours to 2 years; recurrent loneliness recurred every couple of weeks or months; prolonged loneliness lasted for multiple years; and chronic loneliness usually had its onset in childhood or adolescence and persisted for most people's lives. Perceived causes for loneliness were compared across those four temporal patterns, with findings showing that transient or prolonged loneliness was typically attributed to concrete external situations, but chronic loneliness was explained more by unfulfilling family relationships in childhood, perceptions that one does not fit in with societal norms, or high relationship expectations. Both recurrent and chronic loneliness were often attributed to sensitivity, rumination, overgeneralizations in relationships, or discomfort with oneself (e.g., low self-acceptance).","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"114 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145209747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Assal Habibi, Eustace Hsu, Jed Villanueva, Shan Luo
{"title":"Longitudinal Effects of Continuous Music Training on Cognitive Development: Evidence From the Adolescent Brain Cognitive Development (ABCD) Study","authors":"Assal Habibi, Eustace Hsu, Jed Villanueva, Shan Luo","doi":"10.1111/nyas.70086","DOIUrl":"https://doi.org/10.1111/nyas.70086","url":null,"abstract":"Music training has been associated with the development of cognitive and language skills, yet large‐scale longitudinal studies exploring these relationships are still limited. Drawing on data from the Adolescent Brain Cognitive Development (ABCD) Study, we examined the long‐term associations between continuous music engagement and cognitive abilities, including the moderating role of neighborhood socioeconomic deprivation. We also applied classification models to distinguish musicians from non‐musicians on the basis of their performance on cognitive tasks. Our findings revealed that children who are consistently engaged in music training for 2 years scored higher on multiple cognitive and language‐based tasks, with greater gains in picture vocabulary over time compared to non‐musicians. Socioeconomic factors moderated these effects, with non‐musicians from high‐deprivation neighborhoods demonstrating smaller improvements in picture vocabulary than their low‐deprivation counterparts, whereas musicians across socioeconomic backgrounds exhibited similar improvements over time. Additionally, classification models identified a distinct profile in musicians, with cognitive performance serving as a key predictor of music engagement, distinguishing musicians from non‐musicians. These findings reinforce the role of music training in supporting cognitive and language development and highlight its potential as a cognitive enrichment tool, particularly for children from disadvantaged backgrounds.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"78 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}