Electromagnetic fields modulate neuronal membrane ionic currents through altered cellular calcium homeostasis.

IF 4.1 3区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Annals of the New York Academy of Sciences Pub Date : 2025-06-26 DOI:10.1111/nyas.15386

Federico Bertagna,Shiraz Ahmad,Rebecca Lewis,S Ravi P Silva,Johnjoe McFadden,Christopher L-H Huang,Hugh R Matthews,Kamalan Jeevaratnam

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Abstract

The biological effects of electromagnetic fields (EMFs) on the central nervous system (CNS) have been widely reported in the literature. Their nature and extent are thought to depend on parameters such as field intensity and frequency. Of these, extremely low-frequency (50 Hz) fields have been reported to influence neuronal firing in CNS regions, including the hippocampus. We applied the loose patch clamp technique to study the effects of 1 mT exposures of such fields over the course of 60 min on cornus ammonis 1 (CA1) pyramidal neuron membranes in coronal hippocampal slices. Such exposure decreased both inward and transient outward currents. Pharmacological blockers of ryanodine receptor (RyR)-dependent Ca2+ release (dantrolene) and endoplasmic reticular Ca2+ store reuptake (SERCA; cyclopiazonic acid) both abrogated these effects. We thus implicate Ca2+ homeostasis in an EMF-induced modulation of neuronal excitability through its regulation of voltage-gated channels.

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电磁场通过改变细胞钙稳态调节神经元膜离子电流。

电磁场对中枢神经系统（CNS）的生物学效应已被广泛报道。它们的性质和范围被认为取决于场强和频率等参数。其中，据报道，极低频（50赫兹）的电场会影响中枢神经系统区域的神经元放电，包括海马体。本研究采用松膜片钳技术研究了1 mT磁场照射60 min对海马冠状体切片中氨角1 （CA1）锥体神经元膜的影响。这样的暴露减少了向内和瞬态向外电流。ryanodine受体（RyR）依赖性Ca2+释放（dantrolene）和内质网状Ca2+储存再摄取（SERCA）的药物阻滞剂；环吡唑酸)都消除了这些影响。因此，我们暗示Ca2+稳态在emf诱导的神经元兴奋性调节通过其调节电压门控通道。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of the New York Academy of Sciences 综合性期刊-综合性期刊

CiteScore

11.00

自引率

1.90%

发文量

193

审稿时长

2-4 weeks

期刊介绍： Published on behalf of the New York Academy of Sciences, Annals of the New York Academy of Sciences provides multidisciplinary perspectives on research of current scientific interest with far-reaching implications for the wider scientific community and society at large. Each special issue assembles the best thinking of key contributors to a field of investigation at a time when emerging developments offer the promise of new insight. Individually themed, Annals special issues stimulate new ways to think about science by providing a neutral forum for discourse—within and across many institutions and fields.