Annals of the New York Academy of Sciences最新文献_第2页

Correction to “Gatherings in Esophagology: Innovations and Future Directions in the Diagnosis and Management of Reflux Disease” 对“食道学的集会：反流病诊断和治疗的创新和未来方向”的更正

IF 5.2 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2026-04-18 DOI: 10.1111/nyas.70279

引用次数: 0

Super‐Resolution Microscopy for Precision Microsphere Defect Inspection Using Sparrow‐Optimized Autocorrelation Deconvolution 使用麻雀优化的自相关反褶积进行精密微球缺陷检测的超分辨率显微镜

IF 5.2 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2026-04-17 DOI: 10.1111/nyas.70263

Tao He, Jiaxin Yu, Liwei Ou, Qingjie Zheng, Jiahao Ye, Zhenghao Jiang

{"title":"Super‐Resolution Microscopy for Precision Microsphere Defect Inspection Using Sparrow‐Optimized Autocorrelation Deconvolution","authors":"Tao He, Jiaxin Yu, Liwei Ou, Qingjie Zheng, Jiahao Ye, Zhenghao Jiang","doi":"10.1111/nyas.70263","DOIUrl":"https://doi.org/10.1111/nyas.70263","url":null,"abstract":"Precision microspheres have small volumes, making the detection of surface defects challenging with the naked eye. Traditional optical microscopy methods are hindered by issues such as localized blurriness and low resolution, which impede their ability to detect surface defects of microspheres with the precision required. This paper proposes an autocorrelation two‐step deconvolution super‐resolution image reconstruction method using the sparrow search algorithm, which adaptively fine‐tunes the acceleration parameters and optimizes them through a hybrid energy function as the objective. This method enhances image resolution and mitigates the occurrence of artifacts during the reconstruction process. Rolling Fourier ring correlation and full width at half maximum are employed to assess the quality of the reconstructed images. In comparison to the traditional autocorrelation two‐step deconvolution super‐resolution algorithm, the proposed method achieves a resolution enhancement ranging from 2.79 to 3.82 times, depending on the frame count. For equivalent frame counts, the image processing speed increases by 6.3%−34.2%. When compared to various deep learning models, the proposed algorithm reconstructs more detailed features and enhances the detection of surface defects in precision microspheres. It displays a depression effect, which may serve as a valuable reference for the quantitative assessment of surface roughness in precision microsphere images.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"142 1","pages":"e70263"},"PeriodicalIF":5.2,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147702297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Nasal Microbiome in Inflammation and Disease: Bridging Mechanisms to Therapeutics 炎症和疾病中的鼻腔微生物组：连接治疗的机制

IF 4.8 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2026-04-13 DOI: 10.1111/nyas.70258

Xu Zhang, Chunhong Yu, Zhiqiang Zhang, Mengyuan Liu, Xinyu Huang, Daoming Bai, Rui Yang, Peng Wang, Chunping Yang

{"title":"The Nasal Microbiome in Inflammation and Disease: Bridging Mechanisms to Therapeutics","authors":"Xu Zhang, Chunhong Yu, Zhiqiang Zhang, Mengyuan Liu, Xinyu Huang, Daoming Bai, Rui Yang, Peng Wang, Chunping Yang","doi":"10.1111/nyas.70258","DOIUrl":"10.1111/nyas.70258","url":null,"abstract":"<div>\u0000 \u0000 <p>The nasal microbiome, an integral component of the upper respiratory tract's microecological system, plays a pivotal role in inflammatory diseases such as allergic rhinitis and chronic sinusitis, which affect a substantial population and markedly reduce quality of life. A healthy nasal flora and its metabolites are crucial for maintaining immune homeostasis and mucosal barrier integrity. This review comprehensively discusses the pathological mechanisms, immune interactions, and clinical intervention strategies involving the nasal microbiota in nasal inflammation. It has been shown that dysbiosis of the nasal flora disrupts immune function and compromises the epithelial barrier, thereby initiating and exacerbating a vicious cycle of inflammation. Furthermore, the formation of bacterial biofilms and the emergence of drug resistance contribute to persistent and recurrent symptoms. Regarding treatment, while antibiotics may offer short-term efficacy, they risk aggravating the microbial imbalance. In contrast, therapies including probiotics, novel immunomodulators, and traditional Chinese medicine demonstrate significant therapeutic potential by restoring microbial balance and modulating immune responses. This review synthesizes current research to provide new perspectives for understanding host–microbiome interactions and to guide future clinical treatments and drug development.</p>\u0000 </div>","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1558 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147666734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extracorporeal Shock Wave Therapy Promotes Peripheral Nerve Regeneration Through ERK1/2-Mediated Autophagy 体外冲击波疗法通过ERK1/2介导的自噬促进周围神经再生

IF 4.8 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2026-04-11 DOI: 10.1111/nyas.70275

Xingdong Xiang, Xiaoqiong Wu, Shen Ling, Junwen Zhu, Jian Zhang, Tengfei Fu

{"title":"Extracorporeal Shock Wave Therapy Promotes Peripheral Nerve Regeneration Through ERK1/2-Mediated Autophagy","authors":"Xingdong Xiang, Xiaoqiong Wu, Shen Ling, Junwen Zhu, Jian Zhang, Tengfei Fu","doi":"10.1111/nyas.70275","DOIUrl":"10.1111/nyas.70275","url":null,"abstract":"<p>Extracorporeal shock wave therapy (SWT) has shown potential in promoting peripheral nerve regeneration, yet its underlying mechanisms remain incompletely understood. In this study, we explored the role of extracellular signal-regulated kinase 1/2 (ERK1/2)-mediated autophagy in SWT-enhanced nerve repair using both in vivo and in vitro models. Application of SWT to transected sciatic nerves in rats led to increased ERK1/2 phosphorylation and upregulation of the autophagy marker LC3B, as confirmed by immunofluorescence and RT-qPCR. In vitro, SWT-treated Schwann cells exhibited enhanced autophagosome formation and accelerated autophagic flux, correlating with increased axonal outgrowth in cocultured dorsal root ganglion neurons. Pharmacological modulation further revealed that ERK1/2 activation enhanced, while inhibition suppressed, SWT-induced autophagy and neurite extension. Moreover, SWT improved motor recovery in injured rats, as evidenced by enhanced gait performance, sciatic functional index, and electrophysiological recordings. These effects were amplified by cotreatment with the ERK1/2 agonist senkyunolide I and attenuated by the inhibitor SCH772984. Histological and ultrastructural analyses showed enhanced Schwann cell proliferation, axonal integrity, and myelin reorganization following SWT, alongside improved muscle morphology. Collectively, our findings identify ERK1/2-activated autophagy in Schwann cells as a key mechanism mediating the therapeutic effects of SWT, supporting its translational potential for peripheral nerve repair.</p>","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1558 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://nyaspubs.onlinelibrary.wiley.com/doi/epdf/10.1111/nyas.70275","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147648996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection of Mesenchymal Stem Cell Aging Using an Integrin Mechano-Probe 利用整合素机制探针检测间充质干细胞衰老

IF 4.8 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2026-04-09 DOI: 10.1111/nyas.70247

Aimei Liu, Xiaojun Liu, Juan Li, Jiangtao Li, Xinpeng Wang, Yuanjun Dong, Feng Shao, Mingjun Bi, Xiaoyan Deng, Guixue Wang, Yongliang Wang

{"title":"Detection of Mesenchymal Stem Cell Aging Using an Integrin Mechano-Probe","authors":"Aimei Liu, Xiaojun Liu, Juan Li, Jiangtao Li, Xinpeng Wang, Yuanjun Dong, Feng Shao, Mingjun Bi, Xiaoyan Deng, Guixue Wang, Yongliang Wang","doi":"10.1111/nyas.70247","DOIUrl":"10.1111/nyas.70247","url":null,"abstract":"<p>Mesenchymal stem cells (MSCs) play a crucial role in cell therapy, but their efficacy diminishes with age. While biochemical methods like flow cytometry, immunoblotting, β-galactosidase labeling, and gene profiling are effective for screening MSC aging, mechanical factors also change with aging. After analyzing the transcriptomes of young and aged MSCs, we observed downregulation of adhesion-related genes and, based on those data, developed an integrin mechano-probe to measure integrin forces in MSCs. The probe's effectiveness was validated by mapping integrin forces in young and aged MSCs, revealing reduced integrin force signals in aged cells that correlated with downregulated expression of β1 integrins. This finding was further confirmed by flow cytometry and β-galactosidase staining. Overexpression of integrin β1 in aged MSCs restored mechanical signaling and increased p-ERK production, suggesting that the integrin β1/ERK pathway plays a role in rescuing the contractility of aged MSCs. Our mechano-probe enables distinguishing aged MSCs in a mixed pool of young and aged MSCs and identifying aged MSCs taken from mouse tissue. Integrin tension signals, as measured by a mechano-probe, may thus complement biochemical markers in assessing MSC aging.</p>","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1558 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://nyaspubs.onlinelibrary.wiley.com/doi/epdf/10.1111/nyas.70247","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147635748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rolling Bearing Fault Diagnosis Using a Slope-Weighted, Limited Penetrable Horizontal Visibility Graph and Related Indicator 基于斜率加权、有限可穿透水平可视性图和相关指标的滚动轴承故障诊断

IF 4.8 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2026-04-09 DOI: 10.1111/nyas.70268

Xiaohan Cheng, Yuandong Gong, Chenyu Yan, Mingyang Chen, Min Ma, Yongjia Liu

{"title":"Rolling Bearing Fault Diagnosis Using a Slope-Weighted, Limited Penetrable Horizontal Visibility Graph and Related Indicator","authors":"Xiaohan Cheng, Yuandong Gong, Chenyu Yan, Mingyang Chen, Min Ma, Yongjia Liu","doi":"10.1111/nyas.70268","DOIUrl":"10.1111/nyas.70268","url":null,"abstract":"<div>\u0000 \u0000 <p>The reliability and safety of mechanical systems rely heavily on fault diagnosis of rolling bearings. In comparison with traditional graph signals, the changes in the dynamic characteristics of vibration signals are more accurately reflected by the spectra obtained from graph signals converted by the weighted, limited penetrable horizontal visibility graph (WLPHVG). However, its capacity to record changes in the health status of bearings is significantly limited by the selection of the limited penetrable visibility distance, the choice of the weighting method, and the effectiveness of graph spectral feature enhancement and extraction. To address these issues, we developed a slope-weighted, limited penetrable horizontal visibility graph (SWLPHVG) by determining the limited penetrable visibility distance for WLPHVG and developing a slope-weighting approach. This improvement significantly increased the responsiveness of the WLPHVG graph spectrum to the dynamic characteristics of vibration signals. Finally, a fault feature indicator based on spectrum preprocessing, referred to as the graph spectral area of SWLPHVG, was proposed. This indicator revealed both the amplitude distribution and clustering characteristics of the graph spectrum while improving processing efficiency. Experimental results verified the superiority of these measures for fault diagnosis in rolling bearings.</p>\u0000 </div>","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1558 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147635746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Going Beyond Beauty: Characterizing the Complexity of Aesthetic Experiences 超越美：描述审美体验的复杂性

IF 4.8 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2026-04-09 DOI: 10.1111/nyas.70246

Vicente Estrada Gonzalez, Kohinoor Monish Darda, Eileen R. Cardillo, Zuha Nasim, Amy Krimm, Anjan Chatterjee

{"title":"Going Beyond Beauty: Characterizing the Complexity of Aesthetic Experiences","authors":"Vicente Estrada Gonzalez, Kohinoor Monish Darda, Eileen R. Cardillo, Zuha Nasim, Amy Krimm, Anjan Chatterjee","doi":"10.1111/nyas.70246","DOIUrl":"10.1111/nyas.70246","url":null,"abstract":"<div>\u0000 \u0000 <p>Aesthetic experiences have traditionally been evaluated using judgments of beauty and liking. Prior research indicates greater agreement on aesthetic judgments of natural stimuli, such as landscapes and faces, than human-made artifacts like artworks. This variability underscores the subjectivity of art appraisals. This study leverages recent theoretical and methodological advances in empirical aesthetics to investigate the complexity of aesthetic experiences by evaluating individual agreement across impacts more nuanced than global beauty and liking judgments. We hypothesized that complex appraisals are more variable than simpler affective ones. To test this, we employed a comprehensive taxonomy of cognitive and emotional impacts—positive affect, negative affect, immersion/motivation, and epistemic transformation. We also examined how levels of agreement vary by viewing context: museum in-person versus digital online. Participants rated artworks presented in both gallery and digital contexts. Using the mean-minus-one method, we measured individual agreement across aesthetic impact categories. Agreement was highest for traditional preference assessments (liking and beauty), while higher-order impacts, particularly immersion/motivation and epistemic transformation, showed lower agreement. Viewing context did not significantly affect agreement, suggesting enduring aesthetic evaluations. This study highlights that traditional aesthetic evaluations show high agreement, while higher-order impacts are more variable.</p>\u0000 </div>","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1558 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147635912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to “Rhythm Processing across Development: Origins, Links to Language Processing, and Perspectives for Intervention” 对“跨发展的节奏加工：起源、与语言加工的联系以及干预的观点”的更正

IF 4.8 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2026-04-08 DOI: 10.1111/nyas.70280

引用次数: 0

Manifolds in the Medial Premotor Cortex During Switching From Attending to Tapping to a Metronome 从参与到敲击节拍器转换过程中内侧运动前皮层的流形

IF 4.8 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2026-04-07 DOI: 10.1111/nyas.70259

Dobromir Dotov, Abraham Betancourt, Jorge Gámez, Hugo Merchant

{"title":"Manifolds in the Medial Premotor Cortex During Switching From Attending to Tapping to a Metronome","authors":"Dobromir Dotov, Abraham Betancourt, Jorge Gámez, Hugo Merchant","doi":"10.1111/nyas.70259","DOIUrl":"10.1111/nyas.70259","url":null,"abstract":"<p>Animals synchronize their movements with external rhythms to coordinate perception and action, but the neural population mechanisms that allow them to attend and then initiate and sustain these rhythms remain unclear. Using recordings from the medial premotor cortex (MPC) of two macaque monkeys, we investigated neural dynamics during an attend-then-synchronize tapping task with visual metronomes. We found low-dimensional neural manifolds that captured neural population trajectories. During the attention epoch, trajectories exhibited increasing amplitude and oscillatory strength with the successive stimuli, which is consistent with a dynamic system using a resonant mechanism. Then, the transition from perception to tapping synchronization was marked by a reliable shift into a distinct manifold subspace with rotatory dynamics, enabling accurate decoding of the switch in behavior. In addition, correct tapping trials were characterized by a more robust oscillatory structure not seen in incorrect trials. These findings demonstrate that the geometry and coherence of MPC neural trajectories encode different perceptual and motor aspects of tapping synchronization.</p>","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1558 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://nyaspubs.onlinelibrary.wiley.com/doi/epdf/10.1111/nyas.70259","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147630721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Method of Machining Trajectory Planning Based on Multi-View Stereo Vision and Color Regional Growth 基于多视角立体视觉和颜色区域增长的加工轨迹规划方法。

IF 4.8 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2026-04-07 DOI: 10.1111/nyas.70257

Yizhen Yin, Yilong Shi, Weifeng He, Xiaolong Wei, Qichun Hu, Yu Cai, Caizhi Li, Senlin Zhu

{"title":"A Method of Machining Trajectory Planning Based on Multi-View Stereo Vision and Color Regional Growth","authors":"Yizhen Yin, Yilong Shi, Weifeng He, Xiaolong Wei, Qichun Hu, Yu Cai, Caizhi Li, Senlin Zhu","doi":"10.1111/nyas.70257","DOIUrl":"10.1111/nyas.70257","url":null,"abstract":"<div>\u0000 \u0000 <p>To address the challenges of local trajectory planning in robotic manufacturing of curved surface components, this article introduces a method grounded in multi-view stereo reconstruction and color regional growth. Initially, we apply color texture to the surface of a curved component. Subsequently, the improved PatchmatchNet model, which incorporates a high-resolution net and total variation loss, reconstructs high-quality 3D point clouds, achieving 10.42% improvement in accuracy and 10.59% improvement in completeness compared to the baseline. Then, a regional growth point cloud segmentation algorithm based on the hue–saturation–intensity color space and local color distribution similarity is used to segment the color-texture point cloud across three aerospace components with 82.2% <i>Cat.mIoU</i> and 77.1% <i>Ins.mIoU</i>. Following this, point cloud processing and curve fitting are executed on the single-color-texture point cloud, culminating in the derivation of the local processing trajectory feature line. The nonuniform rational B-splines (NURBS) curve fitting generates machining trajectories with <i>R</i><sup>2</sup> exceeding 0.94% and 30% lower root mean square error (RMSE) than polynomial and standard B-spline methods. Real machine grinding experiments validate the method's feasibility, demonstrating precise localization and effective material removal along planned trajectories. The proposed approach addresses critical challenges in local grinding of complex curved surfaces, offering significant practical value for aerospace manufacturing.</p>\u0000 </div>","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1558 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147630364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0