Subbarao Kambhampati, Kaya Stechly, Karthik Valmeekam
{"title":"(How) Do reasoning models reason?","authors":"Subbarao Kambhampati, Kaya Stechly, Karthik Valmeekam","doi":"10.1111/nyas.15339","DOIUrl":"https://doi.org/10.1111/nyas.15339","url":null,"abstract":"We provide a broad unifying perspective on the recent breed of large reasoning models such as OpenAI o1 and DeepSeek R1, including their promise, sources of power, misconceptions, and limitations.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"60 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143824926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Francisco Estrada, Richard S. J. Tol, Wouter Botzen
{"title":"Economic consequences of spatial variation and temporal variability of climate change","authors":"Francisco Estrada, Richard S. J. Tol, Wouter Botzen","doi":"10.1111/nyas.15335","DOIUrl":"https://doi.org/10.1111/nyas.15335","url":null,"abstract":"Damage functions in integrated assessment models (IAMs) map changes in climate to economic impacts and are central to estimating the social cost of carbon (SCC). However, these functions assume no spatial variation (Svar) and temporal variability (Tvar) in climate changes, potentially biasing estimates and policy advice. While the effects of Tvar have been studied, those of Svar and their interactions with Tvar have not. Here, we allow for Tvar, Svar, and seasonality of damages and show that ignoring these factors significantly biases loss and SCC estimates. Under a high emissions scenario, losses are underestimated by 17–45%, representing US$1.9–US$9.7 trillion by 2050 and US$19–US$70 trillion by 2100 (17–35%). The present value of losses over this century exceeds previous estimates by US$38–US$222 trillion, representing 37–218% of 2020 global gross domestic product (GDP). The present value of losses including climate variability represents about 1.2–11.7% of the present value of global GDP over 2020–2100. The SCC increases by US$20/tCO<sub>2</sub>, reaching US$106/tCO<sub>2</sub>. There is large sectoral and regional heterogeneity regarding losses and SCC, with India, Africa, and China accounting for 50% of global SCC, and health and other markets contributing 40%. A more complete climate description than global mean temperature is needed in IAMs to adequately estimate climate change costs.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"108 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143824972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Héctor Vázquez‐Lorente, Lourdes Herrera‐Quintana, Francisco M. Acosta, Francisco J. Amaro‐Gahete, Jonatan R. Ruiz
{"title":"Low‐grade systemic inflammation biomarkers in sedentary young healthy adults are not significantly affected by a 24‐week concurrent training intervention","authors":"Héctor Vázquez‐Lorente, Lourdes Herrera‐Quintana, Francisco M. Acosta, Francisco J. Amaro‐Gahete, Jonatan R. Ruiz","doi":"10.1111/nyas.15329","DOIUrl":"https://doi.org/10.1111/nyas.15329","url":null,"abstract":"In this study, we measured the dose–response effect of a 24‐week concurrent training (CT) intervention on low‐grade systemic inflammation biomarkers in sedentary young healthy adults. A total of 100 untrained participants were randomized to (1) no exercise (control group, <jats:italic>n</jats:italic> = 35), (2) aerobic + resistance exercise (CT) at moderate intensity (exercise‐moderate group; <jats:italic>n</jats:italic> = 33), or (3) CT at vigorous intensity (exercise‐vigorous group, <jats:italic>n</jats:italic> = 32). Serum concentrations of C‐reactive protein (CRP), interleukin‐6 (IL‐6), IL‐7, IL‐8, and IL‐10, interferon‐gamma (IFN‐<jats:roman>γ</jats:roman>), tumor necrosis factor‐<jats:roman>α</jats:roman>, leptin, and adiponectin were determined and compared among the three groups. The exercise‐vigorous group members had lower differences in IL‐7 levels among them, compared to the exercise‐moderate group members (Δ = ‒7.97% vs. 1.90%; <jats:italic>p</jats:italic> = 0.030; 95% CI [‒0.90, ‒0.04]). The exercise‐vigorous group members showed higher differences in CRP values (Δ = 20.1%; <jats:italic>F</jats:italic> = 3.339; <jats:italic>p</jats:italic> = 0.046) compared to both the control (Δ = ‒1.91%) and the exercise‐moderate (Δ = ‒23.3%) group members, whereas the control group exhibited higher differences in IFN‐<jats:roman>γ</jats:roman> levels compared to the exercise‐vigorous group (Δ = 15.3% vs. 2.62%; <jats:italic>p</jats:italic> = 0.048; 95% CI [‒0.68, ‒0.01]). For individuals in the three groups, body composition and physical fitness correlated overall with leptin. The data show, and we concluded, that the training intervention had no significant effect on low‐grade systemic inflammation biomarkers.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"23 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143822829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Neural pathways to resilience: Leveraging neuroscience to understand and mitigate eco-anxiety","authors":"Burcin Ikiz, Joshua M. Carlson","doi":"10.1111/nyas.15347","DOIUrl":"https://doi.org/10.1111/nyas.15347","url":null,"abstract":"As climate change increasingly impacts global health, the psychological ramifications are becoming a significant concern, especially the phenomenon known as eco-anxiety. This anxiety stems from the chronic fear of environmental doom and affects a growing number of individuals, profoundly impacting both personal and collective well-being. Notably, children and adolescents are particularly vulnerable to the mental health effects of climate events, showing heightened symptoms of stress, depression, and anxiety. Eco-anxiety, while sharing similarities with general anxiety disorders in terms of neural mechanisms, also exhibits unique characteristics that underscore its distinction. Research on the neurobiological underpinnings of eco-anxiety reveals that structures within the brain's salience network, such as the midcingulate cortex and the insula, are crucial in detecting and responding to environmental threats. These areas show altered structure and function in individuals experiencing high levels of climate anxiety, correlating with both increased anxiety and engagement in pro-environmental behaviors. Understanding these neurobiological pathways is essential for developing targeted interventions that not only mitigate distress but also enhance psychological resilience. Employing neuroscience-based strategies, such as cognitive behavioral therapy, mindfulness, and neurofeedback, may offer effective tools for managing eco-anxiety, ultimately empowering vulnerable populations to confront climate challenges with renewed vigor and a sense of control.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"74 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143820169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"E-coaching for parents of children with autism spectrum disorder: Protocol for a randomized controlled trial","authors":"Chloé Peter, Evelyne Antonietti, Maria-Paraskevi Antoniou, Elvire Bucaille, Joana Almeida Osório, Sabine Manificat, Borja Rodríguez-Herreros, Nadia Chabane","doi":"10.1111/nyas.15320","DOIUrl":"https://doi.org/10.1111/nyas.15320","url":null,"abstract":"Autism spectrum disorder (ASD) is a neurodevelopmental condition that significantly affects children's development, posing a significant challenge in pediatric healthcare. Early parent-mediated interventions (PMIs) aim to improve a child's social communication skills through joint engagement in daily activities. However, widespread access to this type of intervention is heavily limited due to implementation barriers and logistical challenges. The use of technology may offer promising alternatives to reach more families. This randomized controlled trial will assess the efficacy of an innovative e-coaching program designed to provide parents of young children with ASD with effective strategies via an online learning platform combined with personalized debriefings. It will compare e-coaching to standard Pediatric Autism Communication Therapy and to the absence of a PMI, with all three arms combined with community assistance as usual, in a cohort of 99 families with preschool children with ASD. The primary outcome will be the quality of parent–child interaction, measured through behavioral assessments and simultaneous dual gaze recording with head-mounted eye-tracking during semi-structured standardized play sessions. Secondary outcomes will include the child's developmental level and parental well-being. If validated, e-coaching could be disseminated to reach more families and have a positive impact on their quality of life.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"21 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143814013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kavish Shah, HariOm Vaja, Kahan Patel, Ahan Banker, Jay Shah
{"title":"A case of mixed connective tissue disease with usual interstitial pneumonia and methotrexate-induced erythema multiforme","authors":"Kavish Shah, HariOm Vaja, Kahan Patel, Ahan Banker, Jay Shah","doi":"10.1111/nyas.15333","DOIUrl":"https://doi.org/10.1111/nyas.15333","url":null,"abstract":"Mixed connective tissue disease (MCTD) is a rare autoimmune disorder characterized by overlapping features of various connective tissue diseases. We present a case of a 62-year-old Indian male with a 20-year history of skin tightness and dysphagia, accompanied by a low-grade fever persisting for 1 year. Physical examination revealed sclerodactyly, Raynaud's phenomenon, and perioral sclerosis. High-resolution computed tomography findings indicated a pattern consistent with usual interstitial pneumonia (UIP), characterized by honeycombing and traction bronchiectasis. Laboratory tests confirmed the presence of anti-U1 RNP antibodies. The patient was initially treated with methotrexate, which led to bullous drug eruptions on the palms, lips, and soles, diagnosed as methotrexate-induced erythema multiforme. Following the discontinuation of methotrexate, treatment with mycophenolate mofetil and prednisolone resulted in the resolution of fever and synovitis within 1 month. Over 6 months, there was significant improvement in Raynaud's phenomenon and sclerodactyly. This case highlights the uncommon presentation of UIP in MCTD and the potential for methotrexate to induce bullous eruptions, emphasizing the necessity for cautious use of this medication in patients with connective tissue diseases.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"3 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143814015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The lonely brain: Aligning theories of loneliness with data from neuroimaging studies","authors":"Flora Blandl, Naomi I. Eisenberger","doi":"10.1111/nyas.15330","DOIUrl":"https://doi.org/10.1111/nyas.15330","url":null,"abstract":"Although loneliness is an unpleasant subjective experience associated with negative consequences, decades of research suggest loneliness is accompanied by adaptive cognitive changes that promote self-preservation and attempts for social reconnection. This review summarizes theoretical accounts that elaborate how loneliness alters attention and social information processing, then reviews whether findings from functional magnetic resonance imaging (fMRI) studies align with these hypothesized effects. We first examined the hypothesis that loneliness should increase general attention to monitor for potential environmental threats. Findings from resting-state studies suggested that loneliness corresponds to greater baseline activity in attention-related regions. Next, we examined the hypothesis that loneliness heightens sensitivity to the social world to protect against social threats and motivate reconnection. Here, studies showed sensitivity toward negative social information increased, whereas sensitivity toward positive social information was stimulus dependent (e.g., strangers, close others). Finally, we examined the hypothesis that loneliness enhances mentalizing to better predict social situations. Although many studies support this hypothesis, the research here is limited. However, studies do find that lonely individuals show idiosyncratic processing of the self and others. To conclude, we lay out future directions addressing some shortcomings of current fMRI studies of loneliness, and provide additional avenues to expand our knowledge of the “lonely brain.”","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"16 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143798047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stephen Gareth Hoerpel, Sonja C. Vernes, Uwe Firzlaff
{"title":"Representation of vocalizations in the frontal auditory field and the dorsal auditory cortex of bats","authors":"Stephen Gareth Hoerpel, Sonja C. Vernes, Uwe Firzlaff","doi":"10.1111/nyas.15336","DOIUrl":"https://doi.org/10.1111/nyas.15336","url":null,"abstract":"In bats, which express a complex vocal repertoire and are considered vocal learners, the frontal auditory field (FAF) is supposedly placed in a frontal cortico-striatal network for vocal–motor control. The FAF receives input from the auditory cortex (AC) and other auditory nuclei via multiple pathways. However, not much is known about the transition of information on vocalizations from the AC to the FAF. The bat AC consists of different subfields, among which the dorsal fields (dAC) are characterized by precise coding of the temporal envelope of vocalizations. The dAC should, therefore, be a major source of auditory feedback information about self-produced or perceived vocalizations to the FAF. Our study aimed to investigate the specificity of encoding for different types of vocalizations in FAF and dAC neurons. Using extracellular recordings in anesthetized <i>Phyllostomus discolor</i>, we describe basic response properties in both cortical areas and compare responses to different types of prerecorded vocalizations. The specificity of encoding for different behaviorally relevant call categories and single calls was higher in dAC than in FAF neurons, both in terms of temporal firing patterns and response strength. These findings highlight the importance of the dAC in the neural network for control of vocal communication in bats.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"74 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143798004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shuting Li, Yiyue Zhang, Hanfei Deng, Hu Deng, Chundi Wang
{"title":"Exploring the capacity and executive function of vibrotactile working memory through the frequency sequencing task.","authors":"Shuting Li, Yiyue Zhang, Hanfei Deng, Hu Deng, Chundi Wang","doi":"10.1111/nyas.15327","DOIUrl":"https://doi.org/10.1111/nyas.15327","url":null,"abstract":"<p><p>Working memory (WM) research has primarily focused on visual and verbal information, while relatively little is known about tactile information. This study aims to explore the capacity of vibrotactile WM (vtWM) using the frequency sequencing task, and focuses on its functions in the simultaneous maintenance and transformation of information, supervision, and coordination. We conducted four experiments: Experiments 1 and 2 used the simple frequency sequencing task, while Experiments 3 and 4 added additional processing tasks (a visual processing task and a tactile processing task) to the simple frequency sequencing task. We demonstrated a 3-unit capacity during vtWM that matches Cowan's suggested 3-5 unit chunks of pure WM capacity when memory items cannot be chunked. This measured capacity remains stable across WM tasks with different frequency values. Additionally, the mean accuracies of both the frequency sequencing task and the processing task were significantly different between Experiments 3 and 4. These results provide preliminary evidence for the relative dissociation of tactile and visual executive functions in WM. Taken together, by providing a new method for investigating the capacity of vtWM, the present study expands the field of WM capacity studies to nonverbal and nonvisual modalities.</p>","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A neuroscience perspective on the plasticity of the social and relational brain.","authors":"Tania Singer","doi":"10.1111/nyas.15319","DOIUrl":"https://doi.org/10.1111/nyas.15319","url":null,"abstract":"<p><p>Over the past two decades, the fields of social and contemplative neurosciences have made significant strides. Initial research utilizing fMRI identified neuronal networks involved in empathy, mentalizing, and compassion, as well as complex interactions among these networks. Subsequent studies shifted to testing the plasticity of these social skills via different types of mindfulness- or compassion-based mental training programs, demonstrating brain plasticity, enhanced social capacities and motivation, as well as improved mental health and overall well-being. Next, researchers developed scalable evidence-based online mental training programs to address the growing levels of mental health problems and loneliness, both exacerbated by the COVID-19 pandemic. Innovative approaches, such as novel relational partner-based practices and online app-based dyadic training programs, offer scalable solutions to counteract ongoing societal and mental health deterioration. Current studies are now applying the above findings to support resilience building within diverse domains of society and professional populations-such as healthcare workers and teachers-at high risk of burn-out. Future research should explore the broader impact of such training-related individual changes on larger systems, potentially leading to the development of a translational social neuroscience approach that leverages insights from social brain plasticity research to support societal needs, thereby enhancing resilience, mental health, and social cohesion.</p>","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}