Annals of the New York Academy of Sciences最新文献_第4页

The impact of retrotransposons on zygotic genome activation and the chromatin landscape of early embryos 逆转录转座子对子代基因组激活和早期胚胎染色质景观的影响

IF 5.2 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2024-11-22 DOI: 10.1111/nyas.15260

Therese Solberg, Mie Kobayashi-Ishihara, Haruhiko Siomi

{"title":"The impact of retrotransposons on zygotic genome activation and the chromatin landscape of early embryos","authors":"Therese Solberg, Mie Kobayashi-Ishihara, Haruhiko Siomi","doi":"10.1111/nyas.15260","DOIUrl":"https://doi.org/10.1111/nyas.15260","url":null,"abstract":"In mammals, fertilization is followed by extensive reprogramming and reorganization of the chromatin accompanying the transcriptional activation of the embryo. This reprogramming results in blastomeres with the ability to give rise to all cell types and a complete organism, including extra-embryonic tissues, and is known as totipotency. Transcriptional activation occurs in a process known as zygotic genome activation (ZGA) and is tightly linked to the expression of transposable elements, including endogenous retroviruses (ERVs) such as endogenous retrovirus with leucine tRNA primer (ERVL). Recent studies discovered the importance of ERVs in this process, yet the race to decipher the network surrounding these elements is still ongoing, and the molecular mechanism behind their involvement remains a mystery. Amid a recent surge of studies reporting the discovery of various factors and pathways involved in the regulation of ERVs, this review provides an overview of the knowns and unknowns in the field, with a particular emphasis on the chromatin landscape and how ERVs shape preimplantation development in mammals. In so doing, we highlight recent discoveries that have advanced our understanding of how these elements are involved in transforming the quiescent zygote into the most powerful cell type in mammals.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"8 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142684643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective effects of exercise on responses to combined social and environmental stress in prairie voles 运动对草原田鼠综合社会和环境压力反应的保护作用

IF 5.2 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2024-11-20 DOI: 10.1111/nyas.15264

Dmitry S. Kovalev, Alex Amidei, Oreoluwa I. Akinbo-Jacobs, Jessica Linley, Teva Crandall, Linnea Endsley, Angela J. Grippo

{"title":"Protective effects of exercise on responses to combined social and environmental stress in prairie voles","authors":"Dmitry S. Kovalev, Alex Amidei, Oreoluwa I. Akinbo-Jacobs, Jessica Linley, Teva Crandall, Linnea Endsley, Angela J. Grippo","doi":"10.1111/nyas.15264","DOIUrl":"https://doi.org/10.1111/nyas.15264","url":null,"abstract":"The combination of social and environmental stressors significantly influences psychological and physical health in males and females, and contributes to both depression and cardiovascular diseases. Animal models support these findings. Voluntary exercise may protect against some forms of stress; however, the protective effects of exercise against social stressors require further investigation. This study evaluated the influence of exercise on the impact of combined social and environmental stressors in socially monogamous prairie voles. Following a period of social isolation plus additional chronic environmental stress, prairie voles were either allowed access to a running wheel in a larger cage for 2 weeks or remained in sedentary conditions. A behavioral stress task was conducted prior to and following exercise or sedentary conditions. Heart rate (HR) and HR variability were evaluated after exercise or sedentary conditions. Group-based analyses indicated that exercise prevented elevated resting HR and promoted autonomic control of the heart. Exercise was also effective against social and environmental stress-induced forced swim test immobility. Some minor sex differences in behavior were observed in response to exercise intensity. This research informs our understanding of the protective influence of physical exercise against social and environmental stressors in male and female humans.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"36 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142672928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuromorphic engineering: Artificial brains for artificial intelligence 神经形态工程：人工智能的人工大脑

IF 5.2 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2024-11-20 DOI: 10.1111/nyas.15256

Johannes Leugering

引用次数: 0

Advanced framework for multilevel detection of digital video forgeries. 数字视频伪造多级检测高级框架。

IF 4.1 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2024-11-19 DOI: 10.1111/nyas.15257

Upasana Singh, Sandeep Rathor, Manoj Kumar

{"title":"Advanced framework for multilevel detection of digital video forgeries.","authors":"Upasana Singh, Sandeep Rathor, Manoj Kumar","doi":"10.1111/nyas.15257","DOIUrl":"10.1111/nyas.15257","url":null,"abstract":"The rapid expansion of digital media has sparked significant concerns regarding the swift dissemination and potential misuse of forged video content. Existing forgery detection technologies primarily focus on simple forgeries and are still evolving, resulting in a critical gap in the detection of multilevel forgeries, where one forgery is layered over another. This paper presents an innovative framework designed to address this challenge by extracting intricate features from forged frames using attention-augmented convolutional neural networks (AACNNs). A U-Net-based CycleGAN is employed to accurately localize forged regions, enabling a comprehensive analysis that identifies both two- and three-level forgeries by leveraging AACNN's local and global attention mechanisms. To enhance robustness and accuracy, we integrate a model-agnostic meta-learning approach. Our meticulously curated custom dataset, which represents complex forgery scenarios, underpins the effectiveness of our framework. In a 10-shot scenario, the AACNN backbone achieved an impressive accuracy of 98.2%, alongside a sensitivity of 96.3%, specificity of 97.6%, and an F1-score of 96.8%. These results represent a significant advancement in the accuracy and reliability of sophisticated video forgery detection.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of multidisciplinary therapy on energy balance, inflammation, and metabolic diseases in adolescents with obesity: A narrative review 多学科疗法对肥胖症青少年能量平衡、炎症和代谢疾病的影响：叙述性综述

IF 5.2 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2024-11-16 DOI: 10.1111/nyas.15251

Ana Raimunda Dâmaso, Deborah Cristina Landi Masquio, Raquel Munhoz da Silveira Campos, Flávia Campos Corgosinho, Cintia Cercato

{"title":"Effects of multidisciplinary therapy on energy balance, inflammation, and metabolic diseases in adolescents with obesity: A narrative review","authors":"Ana Raimunda Dâmaso, Deborah Cristina Landi Masquio, Raquel Munhoz da Silveira Campos, Flávia Campos Corgosinho, Cintia Cercato","doi":"10.1111/nyas.15251","DOIUrl":"https://doi.org/10.1111/nyas.15251","url":null,"abstract":"Obesity is a consequence of multiple factors, including genetics, lifestyle and nutritional choices, physical activity, sleep duration, screen time, and mood disorders. These behavioral elements can impair the regulation of energy balance and obesity management that link obesity to a constellation of chronic conditions that lead to a high prevalence of cardiometabolic risk factors, metabolic syndrome, and nonalcoholic fatty liver disease. Multidisciplinary therapy is defined as an approach delivered by a multidisciplinary‐trained health team covering at least two components of behavior, physical activity/exercise, dietary habits, and/or psychological counseling associated with clinical interventions. This narrative review summarizes the effects of multidisciplinary therapy on neuroendocrine regulation of energy balance, inflammatory biomarkers, cardiometabolic risk factors, metabolic syndrome, nonalcoholic fatty liver diseases, behavior, and quality of life. We found that multidisciplinary therapy, including medical, nutritional, exercise, and behavioral counseling, and/or education, was useful for addressing outcomes such as visceral adiposity, neuroendocrine regulation of energy balance, inflammatory biomarkers, cardiometabolic risk factors, nonalcoholic fatty liver disease, and metabolic syndrome. The effects were mediated by improvements in neuroendocrine regulation of energy balance, downregulation of the pro‐inflammatory states, and a reduction in comorbidities. Multidisciplinary therapy also improved mood disorders and quality of life.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"28 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142643216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphologic transformation of ferrofluid during micropump driving under field control. 现场控制下的微泵驱动过程中铁流体的形态变化。

IF 4.1 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2024-11-16 DOI: 10.1111/nyas.15261

Wangxu Li, Zhenggui Li, Wei Han, Ye Wang, Jiali Zhao, Juping Zhou

{"title":"Morphologic transformation of ferrofluid during micropump driving under field control.","authors":"Wangxu Li, Zhenggui Li, Wei Han, Ye Wang, Jiali Zhao, Juping Zhou","doi":"10.1111/nyas.15261","DOIUrl":"https://doi.org/10.1111/nyas.15261","url":null,"abstract":"The superiority of ferrofluid pumps in the fields of biomedical, life science, energy, and power research has been experimentally demonstrated. However, the mechanisms underlying the morphological transformations of ferrofluid fusion and separation during pump driving are not completely understood. To bridge the gap between the theory and practical applications of ferrofluid pumps, we employed optical methods to record the dynamic morphological transformation of rotating and fixed ferrofluids under different magnetic field polarities, magnetic field distributions, and ferrofluid mass fractions. The magnetic field polarity causes dynamic differences in the fusion-separation process of the ferrofluid but does not affect the volume segmentation of the ferrofluid, which depends on the ratio of the magnetic field intensities. When this ratio deviates from one, the morphology of ferrofluid changes, reducing the pumping efficiency. Compared to external environmental factors, the mass fraction does not change the morphology of the ferrofluid. However, high mass fractions lead to wall-clinging of the ferrofluid, and low mass fractions induce bubbles, both of which detrimentally affect the pumping performance. This study reveals the properties of ferrofluid and the effects of external environmental conditions on the morphological transformation of ferrofluid, providing references for optimizing ferrofluid pumps.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142643298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The economics of translating a biosimilar from lab to market in India 印度生物仿制药从实验室走向市场的经济效益

IF 4.1 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2024-11-13 DOI: 10.1111/nyas.15252

Sonia Gandhi, Dhananjay Patankar, Smita Kashiramka, Anurag S. Rathore

{"title":"The economics of translating a biosimilar from lab to market in India","authors":"Sonia Gandhi, Dhananjay Patankar, Smita Kashiramka, Anurag S. Rathore","doi":"10.1111/nyas.15252","DOIUrl":"10.1111/nyas.15252","url":null,"abstract":"This study aims to establish a cost basis for biologics manufacturers and policymakers by quantifying the price and time required to bring a biosimilar from the lab to market. For efficient implementation of a cost-based policy, especially for life-saving medicines like biosimilars, it is imperative to establish a benchmark for the cost involved in biosimilar development. In this holistic and multiple-case study, stage-wise cost estimates of biosimilar development were obtained for microbial and mammalian systems. The investigation of six biopharmaceutical companies based in India concluded that biosimilar development through the microbial system costs ∼18 million USD and ∼21 million USD for the mammalian system. Additionally, 45–50 million USD is required as a one-time capital investment. Further, US/EU authorization can cost ∼25 million USD per product. Clinical studies are the most expensive and account for 60%–70% of total development cost. The presented information can serve as a basis for implementing cost-based pricing in countries like India and reimbursement policies for biosimilars under Medicare Part B in the United States.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1541 1","pages":"219-229"},"PeriodicalIF":4.1,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142610327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The state of the art and future of climate risk insurance modeling 气候风险保险建模的现状与未来

IF 4.1 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2024-11-12 DOI: 10.1111/nyas.15255

Michiel W. Ingels, W. J. Wouter Botzen, Jeroen C. J. H. Aerts, Jan Brusselaers, Max Tesselaar

{"title":"The state of the art and future of climate risk insurance modeling","authors":"Michiel W. Ingels, W. J. Wouter Botzen, Jeroen C. J. H. Aerts, Jan Brusselaers, Max Tesselaar","doi":"10.1111/nyas.15255","DOIUrl":"10.1111/nyas.15255","url":null,"abstract":"This study provides a comprehensive review of the literature on climate risk insurance modeling to identify lessons learned and knowledge gaps to be addressed by future research. These models are increasingly relevant due to the rising losses attributable to climate change. Insurance models estimate risk for different perils and simulate risk-related parameters for insurance schemes, such as premiums and deductibles. Most forward-looking models indicate that climate change and socioeconomic developments highly exacerbate future risk and increase insurance premiums. Various studies recommend charging risk-based premiums to incentivize adaptation efforts that limit this increase in climate risks. Other findings point toward introducing public–private insurance to cope with climate change and enhance risk spreading by introducing insurance purchase requirements or insurance products that cover multiple climate risks. Gaps that we identify in this literature include an underrepresentation of insurance assessments for developing countries and for hazards other than flooding. Additionally, we note a lack of research into insurance for non-agricultural commercial sectors. Furthermore, less than half of the studies take a forward-looking approach by incorporating climate change scenarios, and an even smaller percentage consider socioeconomic development scenarios. This limitation shows that current methods require additional development for assessing the effects of future climate risk on insurance. We recommend that future research develops such forward-looking models, considers using a more refined spatial scale, broadens geographical and hazard coverage, and includes the commercial sector.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1541 1","pages":"100-114"},"PeriodicalIF":4.1,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/nyas.15255","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142599957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimizing the low-temperature performance of high-wax-content crude oil with emulsion-based wax inhibitors: Mechanisms and efficacy 使用乳液型蜡抑制剂优化高蜡含量原油的低温性能：机理与功效。

IF 4.1 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2024-11-02 DOI: 10.1111/nyas.15248

Jiaqiang Jing, Lei Cao, Yuting Shan, Jie Sun, Jiatong Tan

{"title":"Optimizing the low-temperature performance of high-wax-content crude oil with emulsion-based wax inhibitors: Mechanisms and efficacy","authors":"Jiaqiang Jing, Lei Cao, Yuting Shan, Jie Sun, Jiatong Tan","doi":"10.1111/nyas.15248","DOIUrl":"10.1111/nyas.15248","url":null,"abstract":"Wax deposition in constant-temperature transportation of waxy oil with high pour points poses a significant challenge for the oil industry. The demand for efficient methods to solve wax deposition has gained attention. To elucidate the impact of emulsion-based wax inhibitors on the performance of crude oils with varying wax content at low temperatures, experiments, rheological analyses, and microscopic analyses were conducted to study their pour point regulation, low-temperature flow improvement, wax prevention effectiveness, and wax crystallization behavior. The results indicate that emulsion-based wax inhibitors significantly reduce the pour point of crude oil, especially for high-wax-content oil, while for low-wax-content oil, the pour point only decreased by 3°C. By penetrating and dispersing wax crystals, the inhibitor reduced the viscosity of crude oil at low temperatures, enhancing its flowability. At 28°C, crude oil transitioned from a shear-thinning non-Newtonian fluid to a Newtonian fluid at wax inhibitor dosages of 500−750 ppm. At 1000 ppm, the wax prevention rate for high-wax-content oil reached 87.5%, but the effect plateaued beyond this concentration. Additionally, the wax prevention and removal mechanism of the emulsion-based wax inhibitors is discussed. This study confirms that emulsion-based wax inhibitors significantly enhance the low-temperature processability of crude oil, offering a viable strategy for the conveyance and refinement in cold climates.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1541 1","pages":"255-265"},"PeriodicalIF":4.1,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142563930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Virtual reality–based music attention training for acquired brain injury: A randomized crossover study 基于虚拟现实的后天性脑损伤音乐注意力训练：随机交叉研究

IF 4.1 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2024-10-30 DOI: 10.1111/nyas.15249

Eunju Jeong, Yeajin Ham, Su Jeong Lee, Joon-Ho Shin

{"title":"Virtual reality–based music attention training for acquired brain injury: A randomized crossover study","authors":"Eunju Jeong, Yeajin Ham, Su Jeong Lee, Joon-Ho Shin","doi":"10.1111/nyas.15249","DOIUrl":"10.1111/nyas.15249","url":null,"abstract":"This single-blind randomized crossover study aimed to explore the effectiveness of virtual reality–based music attention training (VR-MAT) on cognitive function and examine its potential as a cognitive assessment tool in people with acquired brain injury (ABI). Overall, 24 participants with cognitive impairment secondary to a first-ever ABI underwent VR-MAT and conventional cognitive training (CCT) 3 months after onset. This was performed in two 4-week phases, over 8 weeks. During VR-MAT, participants engaged in attention training through a four-level virtual drumming program designed to enhance various attentional aspects. In contrast, during CCT, participants underwent structured conventional training, including card sorting and computerized training. Neuropsychological evaluations were performed preintervention, during the fourth and eighth weeks, and post-intervention using tests to evaluate attention and executive function, along with global neuropsychological assessments. In the VR-MAT group, significant differences were observed between pre- and post-intervention in the trail making test-black and white version B (p = 0.009) and version B–A (p = 0.018) and clinical dementia rating-sum of boxes (p = 0.035). In the CCT group, significant differences were observed in spatial working memory (p = 0.005) and the mini-mental state examination scores (p = 0.003). VR-MAT is an effective cognitive intervention that is particularly beneficial for improving attention in people with ABI.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1541 1","pages":"151-162"},"PeriodicalIF":4.1,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/nyas.15249","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142541834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0