Annals of the New York Academy of Sciences最新文献_第5页

Balancing act: The dual role of claudin-2 in disease 平衡作用：claudin‐2在疾病中的双重作用

IF 4.1 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2025-03-18 DOI: 10.1111/nyas.15311

Shanshan Wu, Jia Gao, Yiran Han, Wenzhe Zhang, Xue Li, Derun Kong, Hua Wang, Li Zuo

{"title":"Balancing act: The dual role of claudin-2 in disease","authors":"Shanshan Wu, Jia Gao, Yiran Han, Wenzhe Zhang, Xue Li, Derun Kong, Hua Wang, Li Zuo","doi":"10.1111/nyas.15311","DOIUrl":"10.1111/nyas.15311","url":null,"abstract":"Claudin-2 (CLDN2), a tight junction protein, is predominantly found in leaky epithelial cell layers where it plays a pivotal role in forming paracellular pores necessary for the efficient transport of cations and water. Its abundance is intricately regulated by upstream signals, modulating its synthesis, transport, and localization to adapt to diverse environmental changes. Aberrant expression levels of CLDN2 are observed in numerous pathological conditions including cancer, inflammation, immune disorders, fibrosis, and kidney and biliary stones. Recent advances have uncovered the mechanisms by which the loss or restoration of CLDN2 affects functions such as epithelial barrier, cell proliferation, renewal, migration, invasion, and tissue regeneration. This exerts a dual-directional influence on the pathogenesis, perpetuation, and progression of diseases, indicating the potential to both accelerate and decelerate the course of disease evolution. Here, we discuss these nuanced bidirectional regulatory effects mediated by CLDN2, and how it may contribute to the progression or regression of disease when it becomes unbalanced.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1546 1","pages":"75-89"},"PeriodicalIF":4.1,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143653321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cortical and behavioral tracking of rhythm in music: Effects of pitch predictability, enjoyment, and expertise 音乐节奏的皮层和行为追踪：音调可预见性、享受和专业知识的影响

IF 4.1 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2025-03-18 DOI: 10.1111/nyas.15315

Anne Keitel, Claire Pelofi, Xinyi Guan, Emily Watson, Lucy Wight, Sarah Allen, Iris Mencke, Christian Keitel, Johanna Rimmele

{"title":"Cortical and behavioral tracking of rhythm in music: Effects of pitch predictability, enjoyment, and expertise","authors":"Anne Keitel, Claire Pelofi, Xinyi Guan, Emily Watson, Lucy Wight, Sarah Allen, Iris Mencke, Christian Keitel, Johanna Rimmele","doi":"10.1111/nyas.15315","DOIUrl":"10.1111/nyas.15315","url":null,"abstract":"The cortical tracking of stimulus features is a crucial neural requisite of how we process continuous music. We here tested whether cortical tracking of the beat, typically related to rhythm processing, is modulated by pitch predictability and other top-down factors. Participants listened to tonal (high pitch predictability) and atonal (low pitch predictability) music while undergoing electroencephalography. We analyzed their cortical tracking of the acoustic envelope. Cortical envelope tracking was stronger while listening to atonal music, potentially reflecting listeners’ violated pitch expectations and increased attention allocation. Envelope tracking was also stronger with more expertise and enjoyment. Furthermore, we showed cortical tracking of pitch surprisal (using IDyOM), which suggests that listeners’ expectations match those computed by the IDyOM model, with higher surprisal for atonal music. Behaviorally, we measured participants’ ability to finger-tap to the beat of tonal and atonal sequences in two experiments. Finger-tapping performance was better in the tonal condition, indicating a positive effect of pitch predictability on behavioral rhythm processing. Cortical envelope tracking predicted tapping performance for tonal music, as did pitch-surprisal tracking for atonal music, indicating that high and low predictability might impose different processing regimes. Taken together, our results show various ways that top-down factors impact musical rhythm processing.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1546 1","pages":"120-135"},"PeriodicalIF":4.1,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/nyas.15315","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143653320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The beautiful adolescent brain: An evolutionary developmental perspective 美丽的青少年大脑：一个进化发展的视角

IF 4.1 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2025-03-17 DOI: 10.1111/nyas.15314

B. J. Casey, Alexandra O. Cohen, Adriana Galvan

{"title":"The beautiful adolescent brain: An evolutionary developmental perspective","authors":"B. J. Casey, Alexandra O. Cohen, Adriana Galvan","doi":"10.1111/nyas.15314","DOIUrl":"10.1111/nyas.15314","url":null,"abstract":"The adolescent brain has been characterized as a defective car, with no brakes or steering wheel—only an accelerator. This characterization has been used to explain the impulsive and risky behavior of this transient developmental period. But why do adolescents respond to the world the way they do? In this article, we consider adolescent-specific changes in the brain and behavior from a developmental evolutionary viewpoint in how they might be adaptive. We suggest ways in which the adolescent brain has evolved to explore and learn from new and changing environments as the adolescent gains independence from the caregiver and transitions into an adult. We highlight adolescent-specific changes in the brain and behavior in response to emotional and social cues that may facilitate learning to independently secure resources (e.g., food, water, and shelter) and to establish new social bonds beyond the family or pack for their own survival. Specifically, we focus on how rewards, social cues, and threats in the environment influence behavior and may serve an adaptive role for the adolescent.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1546 1","pages":"58-74"},"PeriodicalIF":4.1,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/nyas.15314","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143640695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The strength of organ, tissue, and body field effects determines the frequency of all neoplasia 器官、组织和身体场效应的强度决定了所有肿瘤的发生频率

IF 4.1 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2025-03-17 DOI: 10.1111/nyas.15306

Piet C. de Groen

{"title":"The strength of organ, tissue, and body field effects determines the frequency of all neoplasia","authors":"Piet C. de Groen","doi":"10.1111/nyas.15306","DOIUrl":"10.1111/nyas.15306","url":null,"abstract":"In 1953, Danely Slaughter proposed the concept of field cancerization, or field effect, to explain the development of additional neoplasia of similar type. A recent theory (de Groen, 2022) states that all DNA is exposed to a constant source of damage, resulting in a constant rate of germline and somatic DNA mutations. If the field effect and constant mutation theories are correct and a single somatic mutation causes the transition from non-neoplastic to neoplastic phenotype, then all rates of neoplasia formation can be modeled by exponential equations containing a single variable that determines the chance of phenotype transition. In this perspective, studies from 1953 till 2021 originating from America, Europe, and Asia about head, chest, abdomen, pelvic, and skin neoplasia were reviewed and showed consistent field effects that are modeled by tapering exponential equations containing a single variable defining field effect strength; Pearson and linear correlation coefficients for observed and modeled data range from 0.994 to 1. Thus, existing data are compatible with a constant rate of DNA damage. Organ-specific, tissue-specific, or body-wide mutagenesis conditions determine the rate of neoplasia development and explain the co-occurrence of seemingly unrelated neoplasia at predictable frequencies. Shared risk factors explain increased risk for additional neoplasia in persons with one neoplastic lesion.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1546 1","pages":"11-22"},"PeriodicalIF":4.1,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/nyas.15306","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143640696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differentially expressed miRNAs offer new perspective into cave adaptation of Astyanax mexicanus 差异表达的mirna为墨西哥Astyanax mexicanus洞穴适应提供了新的视角

IF 4.1 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2025-03-13 DOI: 10.1111/nyas.15300

Tathagata Biswas, Huzaifa Hassan, Nicolas Rohner

{"title":"Differentially expressed miRNAs offer new perspective into cave adaptation of Astyanax mexicanus","authors":"Tathagata Biswas, Huzaifa Hassan, Nicolas Rohner","doi":"10.1111/nyas.15300","DOIUrl":"10.1111/nyas.15300","url":null,"abstract":"Astyanax mexicanus, a species with both surface-dwelling and multiple cave-dwelling populations, offers a unique opportunity to study repeated adaptation to dark and resource-scarce environments. While previous work has identified large-scale gene expression changes between morphs under even identical laboratory conditions, the regulatory basis of these expression differences remains largely unexplored. In this study, we focus on microRNAs (miRNAs) as key regulators of gene expression. Our analysis identified 683 mature miRNAs, establishing the first comprehensive catalog of miRNAs for this species. We identified a unique subset of differentially expressed miRNAs common to all studied cave-dwelling populations, potentially orchestrating the nuanced gene expression patterns required for survival in the cave milieu. Furthermore, we performed in silico target prediction of these miRNAs, revealing possible roles in developmental and metabolic pathways pivotal for thriving in nutrient-limited cave conditions. Interestingly, we also observed that Molino, which is the “youngest” of the three cavefish analyzed in this study, exhibited the most abundant number of differentially expressed mature miRNAs among the cave morphs. The comprehensive miRNA catalog generated, along with the insight into their differential expression across different morphs, will guide future investigations into the intricate world of miRNA-mediated evolution of complex traits.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1546 1","pages":"173-181"},"PeriodicalIF":4.1,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/nyas.15300","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143618242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Connecting the dots: Understanding and addressing the metabolic impact of antipsychotic and antidepressant medications 连接点：理解和解决抗精神病和抗抑郁药物的代谢影响

IF 4.1 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2025-03-12 DOI: 10.1111/nyas.15301

Susanne U. Miedlich, J. Steven Lamberti

引用次数: 0

Passive neck brace for surgeons 用于外科医生的被动颈托

IF 4.1 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2025-03-10 DOI: 10.1111/nyas.15308

Zixiao Yang, Tejas S. Sathe, Meghal Shah, Jay Hemant Shah, David L. Hu

{"title":"Passive neck brace for surgeons","authors":"Zixiao Yang, Tejas S. Sathe, Meghal Shah, Jay Hemant Shah, David L. Hu","doi":"10.1111/nyas.15308","DOIUrl":"10.1111/nyas.15308","url":null,"abstract":"A surgeon peers downward into a body cavity when operating. Holding this position for hours across weeks, months, and years may lead to neck pain and musculoskeletal disorders. We were inspired by ungulates such as giraffes and horses, which use dorsal-ventral flexion to graze for 9–14 h per day without perceivable neck pain. Ungulates evolved a strong nuchal ligament that relieves neck muscles by stretching to support some of the weight of the head during grazing or running. In contrast, humans evolved an upright posture, and like many primates, have a reduced nuchal ligament. The goal of this study is to use the nuchal ligament as inspiration for a neck brace that passively supports the weight of the head while still permitting lateral flexion, ventral-dorsal flexion, and rotation. We assembled a prototype using an elastic band, headband, and back posture corrector. Our device augments the human nuchal ligament by using a stiff material and greater mechanical advantage. By our calculations, flexing the head ventrally 40 degrees when wearing the brace reduces the torque applied by neck muscles by 21%. Our device is a proof-of-concept that a bioinspired device can offload neck muscular tension and prevent injury.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1546 1","pages":"112-119"},"PeriodicalIF":4.1,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/nyas.15308","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143583017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Why friendship and loneliness affect our health 为什么友谊和孤独会影响我们的健康

IF 4.1 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2025-03-06 DOI: 10.1111/nyas.15309

Robin I. M. Dunbar

引用次数: 0

Sex differences in caloric nystagmus intensity: Should reference values be updated? 热性眼球震颤强度的性别差异：参考值应该更新吗？

IF 4.1 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2025-03-06 DOI: 10.1111/nyas.15310

Johannes Gerb, Sandra Becker-Bense, Doreen Huppert, Konstanze Dunker, Valerie Schöb, Denis Grabova, Karoline Steinmetz, Ralf Strobl, Andreas Zwergal

{"title":"Sex differences in caloric nystagmus intensity: Should reference values be updated?","authors":"Johannes Gerb, Sandra Becker-Bense, Doreen Huppert, Konstanze Dunker, Valerie Schöb, Denis Grabova, Karoline Steinmetz, Ralf Strobl, Andreas Zwergal","doi":"10.1111/nyas.15310","DOIUrl":"10.1111/nyas.15310","url":null,"abstract":"Bithermal caloric irrigation of the horizontal semicircular canals is a key method of neurotological diagnostics, allowing the detection of peripheral vestibular hypofunction in the low-frequency range. Current diagnostic criteria for unilateral vestibulopathy (UVP), bilateral vestibulopathy (BVP), and presbyvestibulopathy (PVP) rely on gender-neutral absolute or relative metrics. Here, we analyzed all bithermal water caloric examinations performed in the German Center for Vertigo and Balance Disorders (DSGZ) between 07/2018 and 01/2024 and calculated the total caloric reactivity (TR). Patient age and sex were collected as covariates. For UVP, BVP, and PVP diagnoses, international diagnostic criteria were applied. In total, 11,332 patients (6219 females, mean age 55.97±17.52 years) were included. Females displayed a higher TR (mean difference: 6.41°/s, p<0.001). The frequency of UVP, BVP, and PVP diagnoses based on absolute cut-off values showed a significant male predominance (UVP: n = 1144, 548 females, odd ratio [OR] −0.32, p<0.001; BVP: n = 305, 138 females, OR −0.40, p<0.001; PVP: n = 813, 378 females, OR −0.37, p<0.001). However, the rate of UVP based on relative asymmetries showed no sex differences (n = 2971, 1595 females, OR −0.08, p = 0.06). Diagnostic criteria for UVP, BVP, or PVP, which utilize absolute caloric excitability cut-offs, might need to be updated to address sex-specific differences of caloric excitability.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1546 1","pages":"136-143"},"PeriodicalIF":4.1,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/nyas.15310","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143560869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sedentary behavior and sleep for children and adolescents with obesity: A systematic review 儿童和青少年肥胖的久坐行为和睡眠：一项系统综述

IF 4.1 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2025-03-06 DOI: 10.1111/nyas.15303

Jose F. Meneses-Echavez, Lisette Ethel Iglesias-Gonzalez, Andres F. Loaiza-Betancur, Nathaly Chavez Guapo

{"title":"Sedentary behavior and sleep for children and adolescents with obesity: A systematic review","authors":"Jose F. Meneses-Echavez, Lisette Ethel Iglesias-Gonzalez, Andres F. Loaiza-Betancur, Nathaly Chavez Guapo","doi":"10.1111/nyas.15303","DOIUrl":"10.1111/nyas.15303","url":null,"abstract":"Sedentary behavior and inadequate sleep are well-known lifestyle determinants of obesity that are linked to poor health outcomes, including into adulthood. This systematic review aims to synthesize evidence on how sedentary behavior (different durations, frequencies, patterns, or types) and improved sleep and/or sleep hygiene are related to improved health and functioning and reduced obesity-associated disability for the integrated management of obesity. We systematically searched electronic databases and trial registries for randomized trials and prospective cohort studies published between 2012 and 2023. The searches yielded 8990 records, 95 of which were read in full text by independent reviewers. No completed studies met the selection criteria. Only one ongoing study will likely meet the review's selection criteria, but data collection has not yet been completed. The lack of participants with obesity at baseline was the most common exclusion reason (51 studies, 53%), followed by ineligible exposures (12 studies, 12%) like dietary counseling or parenting interventions. As randomized trials and prospective cohort studies concerning sedentary behavior or sleep in children and adolescents have traditionally focused on the primary prevention of obesity, future research should include children and adolescents with obesity and present subgroup analyses for different degrees of obesity and comorbidities.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1545 1","pages":"66-75"},"PeriodicalIF":4.1,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/nyas.15303","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143560872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0