Annals of the New York Academy of Sciences最新文献_第6页

Sex differences in caloric nystagmus intensity: Should reference values be updated? 热性眼球震颤强度的性别差异：参考值应该更新吗？

IF 4.1 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2025-03-06 DOI: 10.1111/nyas.15310

Johannes Gerb, Sandra Becker-Bense, Doreen Huppert, Konstanze Dunker, Valerie Schöb, Denis Grabova, Karoline Steinmetz, Ralf Strobl, Andreas Zwergal

{"title":"Sex differences in caloric nystagmus intensity: Should reference values be updated?","authors":"Johannes Gerb, Sandra Becker-Bense, Doreen Huppert, Konstanze Dunker, Valerie Schöb, Denis Grabova, Karoline Steinmetz, Ralf Strobl, Andreas Zwergal","doi":"10.1111/nyas.15310","DOIUrl":"10.1111/nyas.15310","url":null,"abstract":"Bithermal caloric irrigation of the horizontal semicircular canals is a key method of neurotological diagnostics, allowing the detection of peripheral vestibular hypofunction in the low-frequency range. Current diagnostic criteria for unilateral vestibulopathy (UVP), bilateral vestibulopathy (BVP), and presbyvestibulopathy (PVP) rely on gender-neutral absolute or relative metrics. Here, we analyzed all bithermal water caloric examinations performed in the German Center for Vertigo and Balance Disorders (DSGZ) between 07/2018 and 01/2024 and calculated the total caloric reactivity (TR). Patient age and sex were collected as covariates. For UVP, BVP, and PVP diagnoses, international diagnostic criteria were applied. In total, 11,332 patients (6219 females, mean age 55.97±17.52 years) were included. Females displayed a higher TR (mean difference: 6.41°/s, p<0.001). The frequency of UVP, BVP, and PVP diagnoses based on absolute cut-off values showed a significant male predominance (UVP: n = 1144, 548 females, odd ratio [OR] −0.32, p<0.001; BVP: n = 305, 138 females, OR −0.40, p<0.001; PVP: n = 813, 378 females, OR −0.37, p<0.001). However, the rate of UVP based on relative asymmetries showed no sex differences (n = 2971, 1595 females, OR −0.08, p = 0.06). Diagnostic criteria for UVP, BVP, or PVP, which utilize absolute caloric excitability cut-offs, might need to be updated to address sex-specific differences of caloric excitability.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1546 1","pages":"136-143"},"PeriodicalIF":4.1,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/nyas.15310","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143560869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sedentary behavior and sleep for children and adolescents with obesity: A systematic review 儿童和青少年肥胖的久坐行为和睡眠：一项系统综述

IF 4.1 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2025-03-06 DOI: 10.1111/nyas.15303

Jose F. Meneses-Echavez, Lisette Ethel Iglesias-Gonzalez, Andres F. Loaiza-Betancur, Nathaly Chavez Guapo

{"title":"Sedentary behavior and sleep for children and adolescents with obesity: A systematic review","authors":"Jose F. Meneses-Echavez, Lisette Ethel Iglesias-Gonzalez, Andres F. Loaiza-Betancur, Nathaly Chavez Guapo","doi":"10.1111/nyas.15303","DOIUrl":"10.1111/nyas.15303","url":null,"abstract":"Sedentary behavior and inadequate sleep are well-known lifestyle determinants of obesity that are linked to poor health outcomes, including into adulthood. This systematic review aims to synthesize evidence on how sedentary behavior (different durations, frequencies, patterns, or types) and improved sleep and/or sleep hygiene are related to improved health and functioning and reduced obesity-associated disability for the integrated management of obesity. We systematically searched electronic databases and trial registries for randomized trials and prospective cohort studies published between 2012 and 2023. The searches yielded 8990 records, 95 of which were read in full text by independent reviewers. No completed studies met the selection criteria. Only one ongoing study will likely meet the review's selection criteria, but data collection has not yet been completed. The lack of participants with obesity at baseline was the most common exclusion reason (51 studies, 53%), followed by ineligible exposures (12 studies, 12%) like dietary counseling or parenting interventions. As randomized trials and prospective cohort studies concerning sedentary behavior or sleep in children and adolescents have traditionally focused on the primary prevention of obesity, future research should include children and adolescents with obesity and present subgroup analyses for different degrees of obesity and comorbidities.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1545 1","pages":"66-75"},"PeriodicalIF":4.1,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/nyas.15303","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143560872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The establishment of the 3D genome structure during zygotic genome activation 合子基因组激活过程中三维基因组结构的建立

IF 4.1 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2025-03-03 DOI: 10.1111/nyas.15304

Anastasiia L. Sivkina, Olga V. Iarovaia, Sergey V. Razin, Sergey V. Ulianov

引用次数: 0

Nurturing care in the first 10 years of life: Results from a Vietnamese longitudinal study 在生命的前10年培养关怀：来自越南纵向研究的结果

IF 4.1 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2025-03-03 DOI: 10.1111/nyas.15297

Lan Mai Tran, Aryeh D. Stein, Phuong Hong Nguyen, Melissa F. Young, Usha Ramakrishnan

{"title":"Nurturing care in the first 10 years of life: Results from a Vietnamese longitudinal study","authors":"Lan Mai Tran, Aryeh D. Stein, Phuong Hong Nguyen, Melissa F. Young, Usha Ramakrishnan","doi":"10.1111/nyas.15297","DOIUrl":"10.1111/nyas.15297","url":null,"abstract":"Nurturing care (NC) is essential for children to meet their optimal development potential. However, the various NC dimensions and their patterns from preconception through adolescence have not been comprehensively documented. This study explored five NC dimensions (health, nutrition, safety/security, learning, and relationships) using prospectively collected data from 1040 mother–child dyads in a birth cohort conducted in Vietnam from 2011 to 2023. We described distributions of age-specific variables of the NC dimensions from preconception through ages 2, 6, and 10 years, and generated scaled scores that ranged from 0 to 1. Mean scores varied across dimensions and life stages (range: 0.45–0.83). The scores were 0.1–0.2 points higher among mothers with higher schooling levels. Smaller differences (0.03–0.06 points) in scores were also observed between ethnicities, but no significant difference was observed between boys and girls. We observed positive correlations among most of the five dimensions within each study period (r range: 0.03–0.38). The variation of NC dimensions across different time points indicates a need to measure NC across life stages. Our findings demonstrate important gaps in gaining full achievement in NC from preconception through age 10 years.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1545 1","pages":"145-156"},"PeriodicalIF":4.1,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143532417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human regulatory systems in the age of abundance: A predictive processing perspective 丰富时代的人类调节系统：预测处理视角

IF 4.1 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2025-02-28 DOI: 10.1111/nyas.15302

Otto Muzik, Vaibhav A. Diwadkar

{"title":"Human regulatory systems in the age of abundance: A predictive processing perspective","authors":"Otto Muzik, Vaibhav A. Diwadkar","doi":"10.1111/nyas.15302","DOIUrl":"10.1111/nyas.15302","url":null,"abstract":"Human regulatory systems largely evolved under conditions of food and information scarcity but are now being forced to deal with abundance. The impact of abundance and the inability of human regulatory systems to adapt to it have fed a surge in dual health challenges: (1) a rise in obesity related to food abundance and (2) a rise in stress and anxiety related to information abundance. No single framework has been developed to describe why and how the transition from scarcity to abundance has been so challenging. Here, we provide a speculative model based on predictive processing. We suggest that whereas scarcity (above destructive lower bounds like famine or information voids) preserves the fidelity of the relationship between prediction errors and predictions, abundance distorts this relationship. Furthermore, prediction error minimization is enhanced under scarcity (as the number of competing states in the niche is restricted), whereas the opposite is true under abundance. We also discuss how abundance warps the fundamental drive for seeking novelty by fueling the brain's exploration (as opposed to exploitation) mode. Ameliorative strategies for regulating food and information abundance may largely depend on simulating scarcity, that environmental condition to which human regulatory systems have adapted over millennia.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1545 1","pages":"16-27"},"PeriodicalIF":4.1,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143526342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Healthcare providers’ perceived importance and barriers to addressing social connection in medical settings 医疗保健提供者对解决医疗环境中社会联系的重要性和障碍的认识

IF 4.1 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2025-02-27 DOI: 10.1111/nyas.15295

Julianne Holt-Lunstad, Andrew Scot Proctor, Carla Perissinotto, Angelin Cheng, Thomas K. M. Cudjoe, Ashwin A. Kotwal, Tad Morley

{"title":"Healthcare providers’ perceived importance and barriers to addressing social connection in medical settings","authors":"Julianne Holt-Lunstad, Andrew Scot Proctor, Carla Perissinotto, Angelin Cheng, Thomas K. M. Cudjoe, Ashwin A. Kotwal, Tad Morley","doi":"10.1111/nyas.15295","DOIUrl":"10.1111/nyas.15295","url":null,"abstract":"Despite the well-established significance of indicators of social connection for health and mortality, healthcare providers’ (HCPs) perceptions of the role of social connection in physical health and the extent to which it is considered medically relevant remain unclear. This study examines the perceived importance and barriers to addressing social connection among HCPs in clinical settings. Surveys were completed by 681 HCPs across multiple locations and medical settings. HCPs ranked social connection low in importance among factors known to influence mortality and chronic illness. Furthermore, HCPs report significant barriers to addressing social connection; including lack of time, resources, training, and confidence. The findings have implications for developing educational programs, institutional policies, and structural changes to facilitate the integration of social connection into clinical practices, ultimately improving patient outcomes and overall public health.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1545 1","pages":"132-144"},"PeriodicalIF":4.1,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/nyas.15295","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Short-chain fatty acids mediate gut microbiota–brain communication and protect the blood–brain barrier integrity 短链脂肪酸介导肠道微生物群-脑通讯，保护血脑屏障完整性

IF 4.1 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2025-02-25 DOI: 10.1111/nyas.15299

Mei Chenghan, Li Wanxin, Zhao Bangcheng, He Yao, Li Qinxi, Zhang Ting, Li Xiaojie, Zhang Kun, Zhang Yingqian, Zhong Zhihui

{"title":"Short-chain fatty acids mediate gut microbiota–brain communication and protect the blood–brain barrier integrity","authors":"Mei Chenghan, Li Wanxin, Zhao Bangcheng, He Yao, Li Qinxi, Zhang Ting, Li Xiaojie, Zhang Kun, Zhang Yingqian, Zhong Zhihui","doi":"10.1111/nyas.15299","DOIUrl":"10.1111/nyas.15299","url":null,"abstract":"The human gut, with a complex community of microbes, is essential for maintaining overall health. This gut microbiota engages in two-way communication with the central nervous system, collectively known as the gut microbiota−brain axis. Alterations in gut microbiota have been associated with various neurological disorders, and disruptions to the blood–brain barrier (BBB) may be crucial, though the exact mechanisms remain unknown. In the current study, we investigated the impacts of short-chain fatty acids (SCFAs) on the integrity of the BBB, which was compromised by orally administered antibiotics in rhesus monkeys and C57BL/6n mice. Our results showed that SCFA supplementation notably enhanced BBB integrity in rhesus monkeys with gut dysbiosis. Similar outcomes were observed in mice with gut dysbiosis, accompanied by decreased cortical claudin-5 mRNA levels. In particular, propionate, but not acetate or butyrate, could reverse the antibiotic-induced BBB permeability increase in mice. Additionally, in vitro studies demonstrated that propionate boosted the expression of tight junction proteins in brain endothelial cells. These results suggest that the propionate can maintain BBB integrity through a free fatty acid receptor 2–dependent mechanism. This study offers new insights into the gut−brain axis and underscores potential therapeutic targets for interventions based on gut microbiota.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1545 1","pages":"116-131"},"PeriodicalIF":4.1,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143486173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Age-dependent reduction in voltage-gated inward sodium current and Scn8a gene expression in murine stellate ganglia 鼠星状神经节电压门控内钠电流和Scn8a基因表达的年龄依赖性降低

IF 4.1 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2025-02-25 DOI: 10.1111/nyas.15298

Bonn Lee, Shiraz Ahmad, Charlotte E. Edling, Christopher L.-H. Huang, Fiona E. N. LeBeau, Kamalan Jeevaratnam

{"title":"Age-dependent reduction in voltage-gated inward sodium current and Scn8a gene expression in murine stellate ganglia","authors":"Bonn Lee, Shiraz Ahmad, Charlotte E. Edling, Christopher L.-H. Huang, Fiona E. N. LeBeau, Kamalan Jeevaratnam","doi":"10.1111/nyas.15298","DOIUrl":"10.1111/nyas.15298","url":null,"abstract":"Stellate ganglia (SG) provide sympathetic innervation to the heart and may predispose the myocardial conducting system to arrhythmias. However, little is known about age-related changes in the electrophysiology of murine SG. We investigated alterations in the electrophysiological properties of SG with aging. The loose patch clamp technique was adapted to SG tissue to investigate the voltage-gated ionic currents in its neuronal cells. We compared SG and ventricular cells from young (4 months) and aged (13 months) C57BL/6J mice to explore age-related alterations in their voltage-gated ionic currents (n > 30 patches, eight mice in each group). We observed that the voltage-gated inward sodium current (peak INa(Max)) was significantly decreased with aging in the SG, but not in the ventricle. Additionally, Scn8a gene expression, which encodes the Nav 1.6 channel, was decreased with aging in the SG. Application of loose patch clamp electrophysiology thus suggests that ionic current alterations with age in murine SG could contribute to cardiac autonomic dysregulation in geriatric conditions.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1545 1","pages":"91-104"},"PeriodicalIF":4.1,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/nyas.15298","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143486174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Host diversity mediates the influence of landscape structure on parasite communities in Cerrado agricultural landscapes 寄主多样性介导景观结构对塞拉多农业景观寄生虫群落的影响

IF 4.1 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2025-02-24 DOI: 10.1111/nyas.15292

Wanderson Siqueira Teles, André Luis Regolin, Beatriz Elise de Andrade-Silva, Arnaldo Maldonado Junior, Roberto do Val Vilela, Karen Borges-Almeida, Marcio Junior Pereira, Matheus Lima Araujo, Rosane Garcia Collevatti

{"title":"Host diversity mediates the influence of landscape structure on parasite communities in Cerrado agricultural landscapes","authors":"Wanderson Siqueira Teles, André Luis Regolin, Beatriz Elise de Andrade-Silva, Arnaldo Maldonado Junior, Roberto do Val Vilela, Karen Borges-Almeida, Marcio Junior Pereira, Matheus Lima Araujo, Rosane Garcia Collevatti","doi":"10.1111/nyas.15292","DOIUrl":"10.1111/nyas.15292","url":null,"abstract":"Parasites are key elements in ecosystem functioning owing to their role in hosts’ population dynamics and abundance, regulation stabilizing trophic networks, and shaping community structure. Landscape changes can affect parasite communities because of changes in suitable microhabitats and on hosts’ community structure. In the Brazilian Cerrado, no study has so far analyzed the effects of intensive agricultural landscaping on helminth parasites of mammals. Here, we fill this knowledge gap, addressing the effects of landscape structure and the Sigmodontinae host's community structure on the richness and abundance of helminth parasites in agricultural landscapes. Using structural equation models, we found that the parasites’ richness and abundance are determined mainly by the rodent hosts’ community structure and are only indirectly affected by landscape structure. We found no direct effect of habitat fragmentation, habitat amount, and landscape compositional heterogeneity on the richness and abundance of helminth parasites, but they directly affected the hosts’ community. Moreover, we found no difference in both the host's and parasite's richness and abundance between crop growing and fallow seasons. Our results show that efforts to preserve helminth parasites may comprise landscape conservation strategies that preserve the biodiversity of the rodent hosts, including conservation and restoration of vegetation remnants at the landscape level.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1545 1","pages":"105-115"},"PeriodicalIF":4.1,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143477867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to “Bats as instructive animal models for studying longevity and aging” 对“蝙蝠作为研究长寿和衰老的有指导意义的动物模型”的更正

IF 4.1 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2025-02-20 DOI: 10.1111/nyas.15312

引用次数: 0