Annals of the New York Academy of Sciences最新文献_第6页

IF 4.1 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2024-10-11 DOI: 10.1111/nyas.15237

Brendan A. Daisley, Emma Allen-Vercoe

{"title":"Microbes as medicine","authors":"Brendan A. Daisley, Emma Allen-Vercoe","doi":"10.1111/nyas.15237","DOIUrl":"10.1111/nyas.15237","url":null,"abstract":"Over the last two decades, advancements in sequencing technologies have significantly deepened our understanding of the human microbiome's complexity, leading to increased concerns about the detrimental effects of antibiotics on these intricate microbial ecosystems. Concurrently, the rise in antimicrobial resistance has intensified the focus on how beneficial microbes can be harnessed to treat diseases and improve health and offer potentially promising alternatives to traditional antibiotic treatments. Here, we provide a comprehensive overview of both established and emerging microbe-centric therapies, from probiotics to advanced microbial ecosystem therapeutics, examine the sophisticated ways in which microbes are used medicinally, and consider their impacts on microbiome homeostasis and health outcomes through a microbial ecology lens. In addition, we explore the concept of rewilding the human microbiome by reintroducing “missing microbes” from nonindustrialized societies and personalizing microbiome modulation to fit individual microbial profiles—highlighting several promising directions for future research. Ultimately, the advancements in sequencing technologies combined with innovative microbial therapies and personalized approaches herald a new era in medicine poised to address antibiotic resistance and improve health outcomes through targeted microbiome management.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1541 1","pages":"63-82"},"PeriodicalIF":4.1,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/nyas.15237","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142405303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The links between experiential learning and 4E cognition 体验式学习与 4E 认知之间的联系

IF 4.1 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2024-10-09 DOI: 10.1111/nyas.15238

Angélique Lebert, Óscar Vilarroya

{"title":"The links between experiential learning and 4E cognition","authors":"Angélique Lebert, Óscar Vilarroya","doi":"10.1111/nyas.15238","DOIUrl":"10.1111/nyas.15238","url":null,"abstract":"In this article, we explore the connections between two distinct approaches: experiential learning (EL) and 4E cognition. EL emphasizes the role of concrete experiences as the building blocks of learning, whereas 4E cognition views cognition as arising from the interactions that an individual has with their physical and social environment. Despite their divergent theoretical frameworks, methodologies, and interests, we argue that both frameworks share a common vision of cognition and that their integration could mutually enhance their respective fields. This article outlines the historical origins and underlying assumptions of both frameworks, highlighting the potential links that can be established between them. Specifically, we explore the significance of embodiment, embeddedness, extended cognition, and enactive processes in learning and cognition. To bridge these frameworks, we propose employing the concept of “concrete experience” as an active engagement of individuals with their physical and social surroundings. By encompassing the essential aspects assigned to concrete experiences in EL, as well as the embodiment, situatedness, extended cognition, and enactive features of 4E cognition, this notion serves as a unifying element. Ultimately, the article suggests that combining the insights from EL and 4E cognition can offer a richer, more holistic understanding of representation.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1541 1","pages":"37-52"},"PeriodicalIF":4.1,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/nyas.15238","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142385957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of artificial intelligence in optimizing management of atrial fibrillation in acute ischemic stroke 人工智能在优化急性缺血性脑卒中心房颤动管理中的作用

IF 4.1 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2024-10-08 DOI: 10.1111/nyas.15231

Bill Goh, Sonu M. M. Bhaskar

{"title":"The role of artificial intelligence in optimizing management of atrial fibrillation in acute ischemic stroke","authors":"Bill Goh, Sonu M. M. Bhaskar","doi":"10.1111/nyas.15231","DOIUrl":"10.1111/nyas.15231","url":null,"abstract":"Atrial fibrillation (AF) is a severe condition associated with high morbidity and mortality, including an increased risk of stroke and poor outcomes poststroke. Our understanding of the prognosis in AF remains poor. Machine learning (ML) has been applied to the diagnosis, management, and prognosis of AF in the context of stroke but remains suboptimal for clinical use. This article endeavors to provide a comprehensive overview of current ML applications to AF patients at risk of stroke, as well as poststroke patients without AF. Strategies to develop effective ML involve the validation of a variety of ML algorithms across internal and external datasets as well as exploring their predictive powers in hypothetical and realistic settings. Recent literature of this rapidly evolving field has displayed much promise. However, further testing and innovation of medical artificial intelligence are required before its imminent introduction to ensure complete patient trust within the community. Prioritizing this research is imperative for advancing the optimization of ongoing care for AF patients, as well as the management of stroke patients with AF.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1541 1","pages":"24-36"},"PeriodicalIF":4.1,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142384988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Attention, working memory, and inhibitory control in aging: Comparing amateur singers, instrumentalists, and active controls 衰老过程中的注意力、工作记忆和抑制控制：业余歌唱家、乐器演奏家与活跃对照组的比较

IF 4.1 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2024-10-05 DOI: 10.1111/nyas.15230

Marilyne Joyal, Alexandre Sicard, Virginia Penhune, Philip L. Jackson, Pascale Tremblay

{"title":"Attention, working memory, and inhibitory control in aging: Comparing amateur singers, instrumentalists, and active controls","authors":"Marilyne Joyal, Alexandre Sicard, Virginia Penhune, Philip L. Jackson, Pascale Tremblay","doi":"10.1111/nyas.15230","DOIUrl":"10.1111/nyas.15230","url":null,"abstract":"Despite the ubiquity of musical activities, little is known about the specificity of their association with executive functions. In this cross-sectional study, we examined this relationship as a function of age. Our main hypotheses were that executive functions would decline in older age, that this relationship would be reduced in singers and instrumentalists compared to nonmusician active controls, and that the amount of musical experience would be more strongly associated with executive functions compared to the specific type of activity. A sample of 122 cognitively healthy adults aged 20–88 years was recruited, consisting of 39 amateur singers, 43 amateur instrumentalists, and 40 nonmusician controls. Tests of auditory processing speed, auditory selective attention, auditory and visual inhibitory control, and auditory working memory were administered. The results confirm a negative relationship between age and executive functions. While musicians’ advantages were found in selective attention, inhibitory control, and auditory working memory, these advantages were specific rather than global. Furthermore, most of these advantages were independent of age and experience. Finally, there were only limited differences between instrumentalists and singers, suggesting that the relationship between music-making activities and executive functions may be, at least in part, general as opposed to activity-specific.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1541 1","pages":"163-180"},"PeriodicalIF":4.1,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/nyas.15230","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142377641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bats as instructive animal models for studying longevity and aging 蝙蝠是研究长寿和衰老的有启发性的动物模型。

IF 4.1 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2024-10-04 DOI: 10.1111/nyas.15233

Lisa Noelle Cooper, Mohammad Y. Ansari, Grace Capshaw, Alex Galazyuk, Amanda M. Lauer, Cynthia F. Moss, Karen E. Sears, Mark Stewart, Emma C. Teeling, Gerald S. Wilkinson, Rachel C. Wilson, Thomas P. Zwaka, Rena Orman

{"title":"Bats as instructive animal models for studying longevity and aging","authors":"Lisa Noelle Cooper, Mohammad Y. Ansari, Grace Capshaw, Alex Galazyuk, Amanda M. Lauer, Cynthia F. Moss, Karen E. Sears, Mark Stewart, Emma C. Teeling, Gerald S. Wilkinson, Rachel C. Wilson, Thomas P. Zwaka, Rena Orman","doi":"10.1111/nyas.15233","DOIUrl":"10.1111/nyas.15233","url":null,"abstract":"Bats (order Chiroptera) are emerging as instructive animal models for aging studies. Unlike some common laboratory species, they meet a central criterion for aging studies: they live for a long time in the wild or in captivity, for 20, 30, and even >40 years. Healthy aging (i.e., healthspan) in bats has drawn attention to their potential to improve the lives of aging humans due to bat imperviousness to viral infections, apparent low rate of tumorigenesis, and unique ability to repair DNA. At the same time, bat longevity also permits the accumulation of age-associated systemic pathologies that can be examined in detail and manipulated, especially in captive animals. Research has uncovered additional and critical advantages of bats. In multiple ways, bats are better analogs to humans than are rodents. In this review, we highlight eight diverse areas of bat research with relevance to aging: genome sequencing, telomeres, and DNA repair; immunity and inflammation; hearing; menstruation and menopause; skeletal system and fragility; neurobiology and neurodegeneration; stem cells; and senescence and mortality. These examples demonstrate the broad relevance of the bat as an animal model and point to directions that are particularly important for human aging studies.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1541 1","pages":"10-23"},"PeriodicalIF":4.1,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/nyas.15233","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142374992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The underlying architecture of musical sensibility: One general factor, four subdimensions, and strong genetic effects 音乐感受力的基本结构：一个总体因素、四个子维度和强烈的遗传效应

IF 4.1 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2024-09-28 DOI: 10.1111/nyas.15227

Heidi Marie Umbach Hansen, Espen Røysamb, Olav Mandt Vassend, Nikolai Olavi Czajkowski, Tor Endestad, Anne Danielsen, Bruno Laeng

{"title":"The underlying architecture of musical sensibility: One general factor, four subdimensions, and strong genetic effects","authors":"Heidi Marie Umbach Hansen, Espen Røysamb, Olav Mandt Vassend, Nikolai Olavi Czajkowski, Tor Endestad, Anne Danielsen, Bruno Laeng","doi":"10.1111/nyas.15227","DOIUrl":"10.1111/nyas.15227","url":null,"abstract":"Current evidence suggests moderate heritability of music phenotypes, such as music listening and achievement. However, other fundamental traits underlying people's interest in music and its relevance for their lives have been largely neglected, and little is known about the genetic and environmental etiology of what we refer to as musical sensibility—the tendency to be emotionally and aesthetically engaged by music. This study investigated the latent structure, as well as the genetic and environmental factors influencing individual variability in multiple domains of musical sensibility, and the etiological architecture of the relationship between the dimensions. To this end, we used phenotypic confirmatory factor analytic and biometric twin modeling to analyze self-reported ratings on four dimensions of musical sensibility in a sample of Norwegian twins (N = 2600). The results indicate a phenotypic higher-order structure, whereby both the resulting general musical sensibility factor and the conceptually narrower domains were strongly heritable (49–65%). Multivariate analyses of the genetic and environmental covariance further revealed substantial overlap in genetic variance across domains.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1540 1","pages":"291-306"},"PeriodicalIF":4.1,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/nyas.15227","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142328729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to Modeled impacts of bouillon fortification with micronutrients on child mortality in Senegal, Burkina Faso, and Nigeria 更正塞内加尔、布基纳法索和尼日利亚肉汤强化微量营养素对儿童死亡率的影响模型

IF 4.1 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2024-09-26 DOI: 10.1111/nyas.15235

引用次数: 0

Seventy-five years of impactful environmental and occupational health research at the Nelson Institute of Environmental Medicine at New York University 纽约大学纳尔逊环境医学研究所开展环境和职业健康研究七十五年，影响深远

IF 4.1 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2024-09-25 DOI: 10.1111/nyas.15226

Maarten C. Bosland, Terry Gordon, Jerome J. Solomon, Roy E. Shore, Morton Lippmann

{"title":"Seventy-five years of impactful environmental and occupational health research at the Nelson Institute of Environmental Medicine at New York University","authors":"Maarten C. Bosland, Terry Gordon, Jerome J. Solomon, Roy E. Shore, Morton Lippmann","doi":"10.1111/nyas.15226","DOIUrl":"10.1111/nyas.15226","url":null,"abstract":"Founded in 1947 as the Institute of Industrial Medicine, the Nelson Institute and Department of Environmental Medicine at New York University (NYU) Grossman School of Medicine (NYUGSOM) was supported by a National Institute of Environmental Health Science (NIEHS) Center Grant for over 56 years. Nelson Institute researchers generated 75 years of impactful research in environmental and occupational health, radiation effects, toxicology, and cancer. Environmental health research is continuing at NYUGSOM in its departments of medicine and population health. The objective of this historical commentary is to highlight the major achievements of the Nelson Institute and the department in the context of its history at facilities in Sterling Forest, Tuxedo, NY and Manhattan, NY. Aspects of our discussion include leadership, physical facilities, and research in many areas, including air pollution, health effects of environmental radiation exposures, inhalation toxicology methodology, carcinogenesis by chemicals, metals, and hormones, cancer chemoprevention, human microbiome, ecotoxicology, epidemiology, biostatistics, and community health concerns. The research of the institute and department benefited from unique facilities, strong leadership focused on team-based science, and outstanding investigators, students, and staff. A major lasting contribution has been the training of hundreds of graduate students and postdoctoral fellows, many of whom have been and are training the next generation of environmental and occupational health researchers at various institutions.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1540 1","pages":"147-165"},"PeriodicalIF":4.1,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/nyas.15226","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142317766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Auditory–motor synchronization in developmental coordination disorder: Effects on interlimb coordination during walking and running 发育协调障碍中的听觉-运动同步：对步行和跑步时肢体间协调的影响

IF 4.1 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2024-09-25 DOI: 10.1111/nyas.15228

Mieke Goetschalckx, Peter Feys, Eugene Rameckers, Bart Moens, Marc Leman, Lousin Moumdjian

{"title":"Auditory–motor synchronization in developmental coordination disorder: Effects on interlimb coordination during walking and running","authors":"Mieke Goetschalckx, Peter Feys, Eugene Rameckers, Bart Moens, Marc Leman, Lousin Moumdjian","doi":"10.1111/nyas.15228","DOIUrl":"10.1111/nyas.15228","url":null,"abstract":"Developmental coordination disorder (DCD) presents challenges in motor control. DCD affects tasks such as walking and running and is characterized by poor interlimb coordination and increased spatiotemporal variability compared to typically developing children (TDC). While auditory rhythm synchronization has shown to have benefits for gait performance in adults, its impact on children with DCD during walking and running remains unclear. This study investigated auditory–motor synchronization and interlimb coordination during walking and running in children with and without DCD. Twenty-one DCD and 23 TDC participants aged 8−12 years walked and ran to two different auditory metronomes (discrete and continuous). Synchronization consistency was the primary outcome, with interlimb coordination and spatiotemporal variability as secondary outcomes. Results showed that children with DCD exhibited significantly lower synchronization consistency than TDC, particularly during running. The metronome structure did not influence synchronization ability. Additionally, interlimb coordination differed significantly between DCD and TDC during running and was not impacted by auditory–motor synchronization. Spatiotemporal variability was higher in DCD during both walking and running than in TDC, and accentuated during running. Variability of cadence was influenced by the use of continuous metronomes, which may offer potential benefits in reducing cadence variability.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1540 1","pages":"307-323"},"PeriodicalIF":4.1,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/nyas.15228","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142321102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A proactive phone intervention for older adults to address loneliness identified by a health plan 为老年人提供主动电话干预，解决医疗计划确定的孤独问题。

IF 4.1 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2024-09-24 DOI: 10.1111/nyas.15223

Katrina A. Hough, Soe Han Tha, Carla M. Perissinotto, Preston Burnes, Ashwin A. Kotwal

{"title":"A proactive phone intervention for older adults to address loneliness identified by a health plan","authors":"Katrina A. Hough, Soe Han Tha, Carla M. Perissinotto, Preston Burnes, Ashwin A. Kotwal","doi":"10.1111/nyas.15223","DOIUrl":"10.1111/nyas.15223","url":null,"abstract":"Social isolation and loneliness are associated with poor health and higher health care costs among older adults. Our objective was to determine if older adults identified as at risk for loneliness by a Medicare Advantage health plan could benefit from a proactive telephone support program. We conducted a mixed-methods pilot efficacy study of outbound calls from an established community-based telephone program to support older adults identified as at risk for loneliness. One hundred and twenty-one older adults were enrolled and completed surveys at baseline, 3 months, and 6 months. Outcomes included loneliness (3-item UCLA loneliness scale), depression (PHQ-2 screen), anxiety (GAD-2 screen), and unhealthy physical and mental health days (CDC Healthy Days Measure). Quantitative data were analyzed using multivariable mixed-effects logistic regression, and open-ended responses were analyzed thematically. Over 6 months, participants had reductions in loneliness (46% to 28%, p<0.001), depression (36% to 25%, p = 0.07), anxiety (63% to 43%, p = 0.004), unhealthy mental days (14 to 8, p<0.001), and unhealthy physical days (15 to 11, p<0.001). Participants reported high satisfaction with calls, and many felt the calls improved overall mood or health. Findings can inform trials to address loneliness through telephone support and partnerships between community-based organizations and payors.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1540 1","pages":"191-199"},"PeriodicalIF":4.1,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0