Heliyon最新文献

{"title":"The application and impact of artificial intelligence technology in graphic design: A critical interpretive synthesis.","authors":"Hong Li, Tao Xue, Aijia Zhang, Xuexing Luo, Lingqi Kong, Guanghui Huang","doi":"10.1016/j.heliyon.2024.e40037","DOIUrl":"10.1016/j.heliyon.2024.e40037","url":null,"abstract":"<p><p>In the field of graphic design, the application of Artificial Intelligence (AI) is reshaping the design process. This study employs the Critical Interpretive Synthesis (CIS) approach to explore the impacts and challenges of AI on graphic design. Through a comprehensive review of 33 papers, this research reveals four research paradigms of AI in graphic design: Artificial Intelligence Driven Design Automation and Generation (AIDAG), Artificial Intelligence Assisted Graphic Design and Image Processing (AGDIP), Artificial Intelligence in Art and Creative Design Processes (AACDP), and Artificial Intelligence Enhanced Visual Attention and Emotional Response Modeling (AVERM). These paradigms demonstrate the multidimensional role of AI in design, ranging from automation to emotional interaction. The findings suggest that AI serves a dual role as both a design tool and a medium for innovation. AI not only enhances the automation and efficiency of the design process but also fosters designers' creative thinking and understanding of users' emotional needs. This study also proposes a path for the application of the four paradigms in the graphic design process, providing effective design ideas for future design workflows.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"10 21","pages":"e40037"},"PeriodicalIF":3.4,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11570473/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring chemical properties of essential oils from citrus peels using green solvent.","authors":"Katheryn L Vasquez-Gomez, Diner Mori-Mestanza, Aline C Caetano, Guillermo Idrogo-Vasquez, Carlos Culqui-Arce, Erick A Auquiñivin-Silva, Efraín M Castro-Alayo, Rosita Cruz-Lacerna, Harvey A Perez-Ramos, César R Balcázar-Zumaeta, Llisela Torrejón-Valqui, Cindy Yoplac-Collantes, Ives Yoplac, Segundo G Chavez","doi":"10.1016/j.heliyon.2024.e40088","DOIUrl":"10.1016/j.heliyon.2024.e40088","url":null,"abstract":"<p><p>The research explored the chemical characteristics of essential oils (EOs) extracted from the peels of four citrus fruits grown in northeastern Peru (lime, sweet lemon, mandarin and orange). The essential oils were extracted by hydrodistillation using a green solvent, and subsequently, their physicochemical profile, bioactive, heat capacity, and RAMAN mapping were determined; in addition, the volatile composition was determined by gas chromatography (GC-MS), and the main phenols by liquid chromatography (UHPLC). The results evidenced that sweet lemon and mandarin essential oils had higher antioxidant activity (1592.38 and 1216.13 μmol TE/g) and total phenolic content (680.78 and 420.28 mg GAE/g). In contrast, sweet lemon peel essential oil had the highest total flavonoid content (23.18 mg QE/g). D-limonene was the most abundant aromatic compound in orange (>67 %), mandarin (>70 %), and sweet lemon (>72 %) EOs; however, in the lime, it was the lowest (37 %). The most abundant component was the cyclobutane, 1,2-bis(1-methylethylethylenyl)-, trans- (32 %).</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"10 21","pages":"e40088"},"PeriodicalIF":3.4,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11570516/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolite and mineral contents in root, seed, testa, stem and leaf of <i>Peganum harmala</i> L.","authors":"Xiaoqing Zhu, Munisha Abudouaini, Zhufeng Geng, Na Liu, Ting Peng, Qing He, Yinping Li","doi":"10.1016/j.heliyon.2024.e40009","DOIUrl":"10.1016/j.heliyon.2024.e40009","url":null,"abstract":"<p><p><b>In order to investigate the distribution and accumulation characteristics of metabolites and mineral elements in different parts of <i>Peganum harmala</i> L. (<i>P</i>. <i>harmala</i>), and the synergistic or antagonistic effects between them. In this study, nuclear magnetic resonance (NMR), high performance liquid chromatography (HPLC) and inductively coupled plasma optical emission spectrometer (ICP-OES) were used to determine the contents of metabolites (proline, phosphorylcholine, choline, lysine, 4-hydroxyisoleucine, asparagine, acetic acid, sucrose, harmaline and vasicine) and mineral elements (Ca, Mg, K, P, Na, Cr, Cu, Fe, Zn, Mn, Ni, C, N) in five parts of <i>P</i>. <i>harmala</i>, including root, seed, testa, stem and leaf, and to analyze the relationship among the contents of metabolites and mineral elements. The results showed that the contents of acetic acid, proline, lysine, sucrose and Fe in the root were higher than those in other parts, and the contents of harmaline, phosphorylcholine, P, C, N and Zn in the seeds were the highest. The leaves were rich in vasicine, Na, K, Ca, Mg and Mn. The principal component analysis (PCA) showed that the cumulative variance contribution of the first two principal components was 69.00 %, and the loading values of K, Cu and sucrose were higher, which was consistent with the results of biplot and cluster analysis(HCA). Correlation analysis</b> (<b>CA) results showed that there was a strong overall correlation between the different components of seeds and leaves, and the correlation was greater than that of other parts. The results of this study are helpful to understand the correlation of functional traits among different parts of plants, and determine the internal mechanism of controlling functional traits and the proportional relationship between traits, so as to provide a reference for the resource utilization of plants.</b></p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"10 21","pages":"e40009"},"PeriodicalIF":3.4,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11570479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robust rateless space time block coding for mmWave massive MIMO system.","authors":"Zelalem A Kelem, Habib M Hussein","doi":"10.1016/j.heliyon.2024.e40114","DOIUrl":"10.1016/j.heliyon.2024.e40114","url":null,"abstract":"<p><p>In the vast growing wireless communication system creating robust encoding mechanisms using space-time block codes (STBC) for mmWave massive MIMO to overcome uncertainty and ensure reliability is a critical concept to be covered. This article reviews the core concepts behind MIMO communication, Massive MIMO communication, space-time block codes, and rateless codes in the context of wireless communication systems. Building on the foundational concepts of information theory and mmWave massive MIMO, we developed space-time block codes that maintain orthogonality for real-valued symbols. Following a thorough analysis of these codes, we successfully extended them into rateless orthogonal space-time block codes (ROSTBC) for massive MIMO. This extension enables the codes to adapt their rates dynamically based on the unknown channel conditions at the transmitter. The research work was concluded by comparing static G4 encoded Tarokah work and other Orthogonal Space Time Block Codes (OSTBCs) with Rateless Space Time Block Codes (ROSTBCs). The results show that as the number of blocks used to encode the message in Rateless Space Time Block Code (ROSTBC) increases, this coding scheme can outperform static Rateless Space Time Block Codes (OSTBC) in very low SNR values by a minimum of 8.5 %. This work can enhance wireless communication by creating reliable communication over inherently unreliable systems.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"10 21","pages":"e40114"},"PeriodicalIF":3.4,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11570494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Socio-environmental impacts of hydropower construction in Burundi.","authors":"Jean Marie Ndayiragije, Athanase Nkunzimana","doi":"10.1016/j.heliyon.2024.e40084","DOIUrl":"10.1016/j.heliyon.2024.e40084","url":null,"abstract":"<p><p>Hydropower serves as a very important element of the power system all over the world. And it has positive impacts on both economic development and on slowing down climate change related events such as floods and hydropower do not directly emit greenhouse gas which are ones of the main challenges facing humanity in the world. However, apart from its advantages, there are also various disadvantages of hydropower mainly related to its impacts on natural environment. This article overviews, presents and discusses various socio-environmental impacts of hydropower construction and operation in Burundi. Also, the study classifies direct and indirect impacts of hydropower as well as proposing their mitigation strategies. In this article a crucial aspect that is discussed is a new look at the installed capacity in terms of energy production and the presentation of insufficient generation capacity in Burundi which is one of the Sub-Saharan African countries still with a constant problem of lack of energy. The major negative impacts are changing in water quality, relocation of people, changes in the structure of the land and aquatic communities, loss in agriculture production, landslides and slopes destabilization and changing in climate. Another relevant aspect related with the design and construction of hydropower dams is that there are possibilities of creation of low flow reaches, downstream the reservoir, Therefore the river stretches should be remained with a minimum water flow to lessen the potentialities of the occurrence of hydrological drought and ecological damages.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"10 21","pages":"e40084"},"PeriodicalIF":3.4,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11570518/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the phytochemical, bioactive compounds and descriptive sensory of encapsulated lingzhi (<i>Ganoderma lucidum</i>) extracts with combined wall materials for masking effect on the perception of off-flavour and bitterness.","authors":"Threethip Chuensun, Teera Chewonarin, Witida Laopajon, Rajnibhas Sukeaw Samakradhamrongthai, Worrapob Chaisan, Niramon Utama-Ang","doi":"10.1016/j.heliyon.2024.e40094","DOIUrl":"10.1016/j.heliyon.2024.e40094","url":null,"abstract":"<p><p>Lingzhi mushroom (<i>Ganoderma lucidum</i>) is known as a medicinal mushroom that can be utilized in various functional foods available in the market, including powders, dietary supplements, and tea. However, its use is limited due to factors such as bitterness, flavour, and astringency. The objective of this study is to characterize and quantify the sensory profile of Lingzhi mushroom samples (fresh, dried and Lingzhi extracts) using quantitative descriptive analysis and investigate the physicochemical and sensory properties of encapsulated Lingzhi extracts using different ratios of wall material (maltodextrin, gum Arabic and modified starch from rice flour). The optimal ratio for encapsulation involved 32.75 % maltodextrin, 42.25 % gum Arabic, and 25 % modified starch w/w. Three parallel experiments were performed under practical conditions, resulting in average encapsulation efficiencies of 88.39 ± 0.09 % for flavonoids 89.53 ± 0.06 % for polysaccharides and 0.31 ± 0.01 of water activity. The sensory descriptive analysis indicated the following ratings: brown sugar aroma (4.36 ± 0.17), earthy aroma (22.04 ± 0.12), nutty aroma (2.00 ± 0.01), fresh mushroom aroma (11.18 ± 0.19), dried Lingzhi aroma (3.08 ± 0.13), black tea aroma (4.50 ± 0.19), salty taste (1.00 ± 0.01), earthy flavour (23.14 ± 0.22) and Mushroomy (after taste) (2.06 ± 0.09), respectively. The flavour identified of Lingzhi extracts and encapsulated by gas chromatography electronic nose (GC-E-Nose). The result showed ten flavour compounds (Acetaldehyde, Methanethiol, Propanal, propane-2-one, Methyl acetate, 2-methyl propanal, Ethyl Acetate, Heptane, 1-Butanamine, 2-methyl butanal, Thiophene). Optimizing the encapsulation conditions has a significant impact on reducing off-flavours and bitterness. Comparing the flavour profiles of Lingzhi extracts with encapsulated Lingzhi extracts using gas chromatography electronic nose (GC-E-Nose). Encapsulation technology represents a burgeoning field that holds immense potential in ensuring the stability of functional ingredients and facilitating their incorporation into instant beverage products.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"10 21","pages":"e40094"},"PeriodicalIF":3.4,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11570458/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated effects of furrow irrigation systems and irrigation regimes on water productivity of onion (Allium <i>cepa</i> L.) crop in a semi-arid area.","authors":"Getachew Wandifra Boru, Tigabie Setu Birhan, Terhas Legese Beyene","doi":"10.1016/j.heliyon.2024.e40098","DOIUrl":"10.1016/j.heliyon.2024.e40098","url":null,"abstract":"<p><p>Dwindling water resources with inept field water management impends sustainable agricultural production in semi-arid areas of Ethiopia. Thus, the adaption and adoption of improved irrigation water running lines are indispensable and imperative to recuperate water productivity in areas where water resources are inadequate. The ground experiments were pointed to elucidate the weight of conventional, alternate, and fixed furrow irrigation systems under irrigation levels of 100 %, 70 %, and 40 % of crop evapotranspiration (ETc) on onion growth, yield, water productivity, and economic return in Alage, Central, Ethiopia. The field trials were conducted at nine treatments arranged in a randomized complete block design with three replications and water was managed at fixed intervals with variable depth approach. The result illustrated that furrow systems in conjunction with irrigation levels had a weighty pertain (P < 0.05) on onion growth, yield, water productivity, and economic return. The highest yield of 30.75 ton ha^-1 was achieved at conventional furrow irrigation with 100%ETc dictated to zero water saving subsequently, the crop and irrigation water productivity dropped with the values of 6.86 and 5.61 kg m^-3 respectively. The diminished yield of 6.39 ton ha^-1 obtained at fixed furrow irrigation with 40%ETc conquered the saved water output lastly, the crop and irrigation water productivities demoted with values of 6.87 and 5.70 kg m^-3 respectively. Nevertheless, 24.93ton ha^-1 of ideal yield was obtained under alternative furrow irrigation with 100%ETc and the 50 % hoarded water was higher than the yield decline. Consequently, the crop and irrigation water productivities rose with values of 10.96 and 9.09 kg m^-3 respectively. Eventually, the saved water opened for 0.03ha extra irrigable area that will onward to the highest total expected yield of 37.40 ton ha^-1 as compared with all other treatments. Under conventional furrow irrigation with 100%ETc, the obtained yield dominated the wastewater accordingly, the highest net return of 668484ETB ha^-1 and benefit-cost ratio of 3.63 was achieved. Besides, the unbearable yield penalty under fixed furrow with 40 % headed to negative net return and lowest befit cost ratio as related with other treatments. However, further economic results confirmed that the 50 % saved water under alternative furrow with 100 % can recompense for the net return reduction that will make this trial combination preferable as compared with other treatments. Other results also recommended that, under water-limiting and inefficient field water governing conditions, alternative furrow irrigation with 100%ETc can be the ideal blend to enhance water productivity in semi-arid regions of Ethiopia and elsewhere that share similar agroclimatic conditions.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"10 21","pages":"e40098"},"PeriodicalIF":3.4,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11570297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of different transfer strategies for in vitro fertilization/intracytoplasmic sperm injection with poor-quality embryos-Analysis of embryonic development, perinatal period, and neonatal outcomes.","authors":"Lei Jin, Zhou Li, Keyi Si, Bingxin Ma, Xinling Ren, Bo Huang","doi":"10.1016/j.heliyon.2024.e40103","DOIUrl":"10.1016/j.heliyon.2024.e40103","url":null,"abstract":"<p><p>During the in vitro fertilization and embryo transfer process, some expectant mothers may not have good embryos to choose from before the embryo transfer. Recommendations for this condition are currently unclear, and relevant clinical and neonatal outcomes are still lacking. This study analyzed the outcomes of poor-quality embryo transfers, including fetal outcomes, in the fresh cycle and frozen-thawed embryo transfer cycle. Embryos were also analyzed for abnormalities during the cleavage stage. The results indicate that in the absence of good embryos, clinicians and embryologists could advise expectant mothers to continue culturing the embryos to the blastocyst stage and undergo transfer if blastocysts are formed. This finding can also be used as a reference for many expectant mothers with frozen embryos that have not yet been thawed.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"10 21","pages":"e40103"},"PeriodicalIF":3.4,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11570467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human exposure to chromite mining pollution, the toxicity mechanism and health impact.","authors":"Changaiz Khan, Riffat Naseem Malik, Jing Chen","doi":"10.1016/j.heliyon.2024.e40083","DOIUrl":"10.1016/j.heliyon.2024.e40083","url":null,"abstract":"<p><p>Significant amounts of toxic metal-containing mining waste are produced by chromium mining activities, along with the production of air pollutants. The presence of toxic metals in various environmental media including air, water, and soil, along with their chemical species such as hexavalent chromium, pose major health hazards for both directly exposed mining workers and the population residing near the mining areas. Highlighting the requirements for enhanced environmental protection and safety measures, this comprehensive review shed light on the global environmental pollution stemming from chromite mining activities. Based on the published literature, the study also investigated into the pollution caused by toxic metals and explored their probable health effects on exposed individuals. The exposure routes and the mechanisms of toxic metal induced carcinogenicity in the exposed groups were assessed. Additionally, the generated reactive species in exposed individuals and the toxicity mechanisms of hexavalent chromium were discussed. Considering these findings, this review proposed the necessity of cross-sectional biomonitoring studies involving occupationally exposed workers from chromite mining operations. The anticipated impact of this review is to influence the global and national chromite mining industry, instigating improvements in occupational settings, real-time pollution monitoring, and healthcare provisions for exposed workers.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"10 21","pages":"e40083"},"PeriodicalIF":3.4,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11566874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relative fitness of wild-type and phage-resistant pyomelanogenic <i>P. aeruginosa</i> and effects of combinatorial therapy on resistant formation.","authors":"Aarcha Shanmugha Mary, Nashath Kalangadan, John Prakash, Srivignesh Sundaresan, Sutharsan Govindarajan, Kaushik Rajaram","doi":"10.1016/j.heliyon.2024.e40076","DOIUrl":"10.1016/j.heliyon.2024.e40076","url":null,"abstract":"<p><p>Bacteriophages, the natural predators of bacteria, are incredibly potent candidates to counteract antimicrobial resistance (AMR). However, the rapid development of phage-resistant mutants challenges the potential of phage therapy. Understanding the mechanisms of bacterial adaptations to phage predation is crucial for phage-based prognostic applications. Phage cocktails and combinatorial therapy, using optimized dosage patterns of antibiotics, can negate the development of phage-resistant mutations and prolong therapeutic efficacy. In this study, we describe the characterization of a novel bacteriophage and the physiology of phage-resistant mutant developed during infection. M12PA is a <i>P. aeruginosa</i>-infecting bacteriophage with Myoviridae morphology. We observed that prolonged exposure of <i>P. aeruginosa</i> to M12PA resulted in the selection of phage-resistant mutants. Among the resistant mutants, pyomelanin-producing mutants, named PA-M, were developed at a frequency of 1 in 16. Compared to the wild-type, we show that PA-M mutant is severely defective in virulence properties, with altered motility, biofilm formation, growth rate, and antibiotic resistance profile. The PA-M mutant exhibited reduced pathogenesis in an allantoic-infected chick embryo model system compared to the wild-type. Finally, we provide evidence that combinatory therapy, combining M12PA with antibiotics or other phages, significantly delayed the emergence of resistant mutants. In conclusion, our study highlights the potential of combinatory phage therapy to delay the development of phage-resistant mutants and enhance the efficacy of phage-based treatments against <i>P. aeruginosa</i>.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"10 21","pages":"e40076"},"PeriodicalIF":3.4,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11570307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}