Heliyon最新文献

{"title":"Decision support systems for waste-to-energy technologies: A systematic literature review of methods and future directions for sustainable implementation in Ghana.","authors":"Theophilus Frimpong Adu, Lena Dzifa Mensah, Mizpah Ama Dziedzorm Rockson, Francis Kemausuor","doi":"10.1016/j.heliyon.2025.e42353","DOIUrl":"https://doi.org/10.1016/j.heliyon.2025.e42353","url":null,"abstract":"<p><p>Waste-to-energy (WtE) technologies play a crucial role in sustainable waste management and energy production. Decision-making in this context requires a comprehensive and structured approach to balance the environmental, socio-economic, and technical dimensions. This systematic literature review aims to provide an overview of the applications of Decision Support Systems (DSS) in the field of WtE, identify key trends, and outline future research directions. The study utilized the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) approach in analyzing and synthesizing a diverse range of studies to identify key observations, trends, and a pathway for future research. The study has addressed its primary objectives through a rigorous analysis of existing scholarship, identification of essential decision-making criteria, assessment of DSS methodologies' efficacy, and identification of knowledge gaps and future research directions. The review reveals that DSS methodologies, particularly Multi-Criteria Decision Analysis (MCDA), Geographic Information Systems (GIS), and Life Cycle Assessment (LCA), have significantly contributed to enhancing decision-making processes in the WtE sector globally. These tools have demonstrated their effectiveness in handling the complex, multi-faceted nature of WtE technology selection and implementation, addressing issues ranging from site selection to technology ranking based on multiple criteria. The research identifies key criteria for WtE technology selection in Ghana, including technical feasibility, environmental impact, economic viability, social acceptability, and energy efficiency. The study also highlights significant gaps in the current application of DSS to WtE technologies, particularly in the context of developing nations like Ghana. Many existing DSS approaches fail to adequately account for local socio-economic factors, rely on static data, and do not fully incorporate diverse stakeholder perspectives. Adapting global DSS applications to the Ghanaian context requires careful consideration of local priorities, data availability, and the role of the informal waste sector. The review proposes a holistic approach to DSS development, emphasizing the need for context-specific, dynamic, and inclusive methodologies. Future research directions identified by this study include the development of Ghana-specific DSS models, integration of real-time data collection methodologies, creation of user-friendly interfaces for local decision-makers, and exploration of emerging technologies such as blockchain and IoT or Machine learning (ML) for enhancing DSS in WtE management.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 3","pages":"e42353"},"PeriodicalIF":3.4,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11849082/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effects of Pyrogallol and Caffeic acid against Fe²⁺ -Ascorbate-induced oxidative stress in the wistar rats liver: An in vitro study.","authors":"Seifollah Bahramikia, Nasrin Shirzadi, Vali Akbari","doi":"10.1016/j.heliyon.2025.e42518","DOIUrl":"https://doi.org/10.1016/j.heliyon.2025.e42518","url":null,"abstract":"<p><p>Regarding the role of oxidative damage to various tissues in various diseases, using antioxidant compounds that protect tissues from damage is proposed as an important strategy against these diseases. Liver homogenates are frequently employed as in vitro models for investigating oxidative stress owing to the liver's high metabolic activity and susceptibility to oxidative damage. In this study, we assessed the protective effects of two phenolic compounds on Fe²⁺-ascorbate-induced oxidative stress in liver homogenates by analyzing various markers such as lipid peroxidation, protein carbonyl oxidation (PCO), reduced glutathione (GSH), and ROS levels. Catechin was used as a reference antioxidant to compare with the results. The DPPH radical scavenging activity of the compounds was also evaluated. Our findings demonstrated that co-incubation of liver homogenates with the Fe²⁺-ascorbate system and the compounds at various concentrations (10, 25, 50, and 100 μg/mL) led to a dose-dependent reduction in lipid peroxidation, PCO levels, ROS production, and GSH depletion. Furthermore, the IC₅₀ values for DPPH free radicals for pyrogallol and caffeic acid were determined to be 76.26 μg/mL and 106.31 μg/mL, respectively. Notably, pyrogallol and caffeic acid exhibited higher antioxidant activity in all assays than catechin. In most assays (DPPH, Lipid peroxidation, and PCO) and at high concentrations (50 and 100 μg/mL), the antioxidative stress activity of pyrogallol was higher than that of caffeic acid. In conclusion, this study's results suggest that these compounds can potentially ameliorate diseases associated with oxidative stress.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 3","pages":"e42518"},"PeriodicalIF":3.4,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11849609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Illicit drug use derived from wastewater-based epidemiology in Iran, their removal during wastewater treatment, and occurrence in receiving waters.","authors":"Anvar Asadi, Shabnam Zarei, Nebile Daglioglu, Evsen Yavuz Guzel, Neda Ravankhah","doi":"10.1016/j.heliyon.2025.e42516","DOIUrl":"https://doi.org/10.1016/j.heliyon.2025.e42516","url":null,"abstract":"<p><p>This study aimed to measure the licit and illicit drug concentrations in wastewater treatment plants (WWTPs), their removal efficiency, and their consumption rate by wastewater-based epidemiology (WBE) approach. A 2-season monitoring program was undertaken for the first time in Iran. Residues of licit and illicit drugs (amphetamine, 3,4-methylenedioxyamphetamine, methamphetamine, codeine, 3,4-methylenedioxymethamphetamine, heroin, cocaine, and methadone) and major metabolites (benzoylecgonine, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine and 6-monoacetylmorphine) were analyzed by LC-MS/MS in composite sampling after solid phase extraction method. These analytes were also measured in rivers vicinity to selected cities. The detected concentration in raw wastewater was converted into the quantity of illicit drugs per capita using back-calculation. There was no detection of cocaine, its metabolite benzoylecgonine, or 3,4-methylenedioxymethamphetamine in any of the samples. Among the analytes measured, morphine and codeine exhibited the most prevalent occurrence and highest concentration levels in all the samples. Heroin was the main illicit drugs used in the studied population with a mean consumption rate of 6108 and 158 mg/day/1000 inh. in cold and warm seasons, respectively. The removal efficiencies of drugs during wastewater treatment ranged from 3.5 % (3,4-methylenedioxyamphetamine) to >99 % (amphetamine, methamphetamine, and codeine); however, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine demonstrated a negative removal within WWTPs. This study provides crucial insights into the consumption of illicit drugs in Iran, as well as the release of illicit drugs and their metabolites through WWTPs.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 3","pages":"e42516"},"PeriodicalIF":3.4,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11849611/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic rate and insulin-independent glucose uptake increase in a TDP-43^Q331K mouse model of amyotrophic lateral sclerosis.","authors":"Tanya S McDonald, Cedric S Cui, Titaya Lerskiatiphanich, Jianina Marallag, John D Lee","doi":"10.1016/j.heliyon.2025.e42482","DOIUrl":"https://doi.org/10.1016/j.heliyon.2025.e42482","url":null,"abstract":"<p><p>Impaired glucose regulation is increasingly recognised in amyotrophic lateral sclerosis (ALS), yet the precise mechanisms remain unclear. Here, we investigated energy balance and glucose control in TAR DNA-binding protein 43 (TDP-43)^Q331K mice, a model of ALS, at both the early and late symptomatic stages of disease. Mutant TDP-43^Q331K mice and non-transgenic controls underwent indirect calorimetry, as well as intraperitoneal glucose, insulin, and glucagon tolerance testing. We also examined plasma hormone levels and quantified α- and β-cell areas in pancreatic islets. Throughout disease progression, TDP-43^Q331K mice exhibited elevated metabolic rates, with a transient increase in food intake at the early stages. At the later stages of disease, heightened glucose uptake was observed despite unchanged insulin secretion or tolerance, indicating mechanisms independent of insulin. Notably, TDP-43^Q331K mice maintained fasting blood glucose levels even when circulating glucagon levels were reduced, suggesting that alternative pathways contribute to preserving euglycemia. These findings reveal a distinct metabolic profile in TDP-43^Q331K mice, underscoring the complexity of glucose dyshomeostasis in ALS.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 3","pages":"e42482"},"PeriodicalIF":3.4,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11849610/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-citation pattern among world's top 2 % of the scientists.","authors":"Berun A Abdalla, Ayman M Mustafa, Fattah H Fattah, Fahmi H Kakamad, Sami S Omar, Ameer M Salih, Aso S Muhialdeen, Jaafar Omer Ahmed, Rawa Bapir, Shvan H Mohammed, Karokh K Mohammed, Hiwa O Baba, Sasan M Ahmed, Shevan M Mustafa, Kayhan A Najar","doi":"10.1016/j.heliyon.2025.e42471","DOIUrl":"https://doi.org/10.1016/j.heliyon.2025.e42471","url":null,"abstract":"<p><p>Although self-citation is a common practice among scholars, its impact and significance remain under scrutiny within the academic community. The current study aimed to provide a detailed analysis and ranking of the top 2 % scientists on self-citation, ranked by Stanford University researchers. Data extraction and organisation were performed between January and February 2024. Self-citation percentages were collected for authors belonging to 20 fields and 174 subfields using Excel spreadsheets. Entities were categorised into quartiles based on their self-citation percentages and rankings were assigned accordingly. Comparative analyses were conducted to assess the impact of self-citations on overall rankings. The study focused on data published by a group of researchers from Stanford University regarding the top 2 % of researchers, analysing the career-long records of 204,643 scholars and 210,198 scholars for the most recent year, 2022. Notably, in the single-year analysis, among the top 20 countries, approximately eight (40 %) exhibited self-citation percentages exceeding the average of 25.96 %. The self-citation percentages ranged from 4.47 % in Economics and Business to 20.88 % in Physics and Astronomy. Regarding career-long analysis, the percentage of self-citations ranged from 22.84 % in Poland to 41.31 % in Armenia, with significant drop in rankings among most entities when self-citations were excluded. These findings highlight the dramatic impact of self-citation exclusion on the rankings of the top 2 % of the researchers, underscoring the critical importance of accounting for self-citation in ranking assessments.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 3","pages":"e42471"},"PeriodicalIF":3.4,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11849628/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to teach the anatomy of the inguinal canal? A multimodal approach.","authors":"Shina Yeo Qing Chun, Nathaniel Dexter Salim, Lai YuFu Jarrell, Joshua Koh Zhi Yuan, Eng-Tat Ang, Davide Lomanto","doi":"10.1016/j.heliyon.2025.e42434","DOIUrl":"https://doi.org/10.1016/j.heliyon.2025.e42434","url":null,"abstract":"<p><strong>Introduction: </strong>Learning the anatomy of the inguinal canal is challenging for medical students and residents. Current teaching via didactic lectures may not suffice for optimal learning, and visualization of the complicated 3D-structure of the inguinal canal. Hence, we investigated the efficacy of a low-fidelity model creation to improve the teaching.</p><p><strong>Materials and methods: </strong>30 pre-clinical students were split into three groups and assigned different teaching interventions: 1) Lecture (Group L), 2) Lecture with individual model creation (Group M1), and 3) Lecture with group model creation (Group M2). Gain in knowledge were assessed through a pre- and post-intervention multiple-choice quizzes (MCQs), while perceptions of confidence/engagement/model efficacy were measured using post-intervention questionnaires.</p><p><strong>Results: </strong>For knowledge acquisition, average MCQ scores improved most for Group L (23 ± 1%), followed by M1 (19 ± 1%) and M2 (13 ± 1%). In learning the inguinal canal, perceived confidence was enhanced by modelling compared to lecture only (p < 0.05). There was no difference between group M1 and M2 respectively. Perceived engagement had also been enhanced by modelling compared to lecture only (p < 0.05). Interestingly, there was statistical difference between M1 and M2 (p < 0.05). However, perceived usefulness of the model compared to lecture only was insignificant (p > 0.05). There was also no difference between M1 and M2 (p > 0.05).</p><p><strong>Conclusion: </strong>As a supplement to didactic teaching of the inguinal canal, model creation was well-received, and provided opportunities for experiential learning. However, the usefulness of modelling in learning the anatomy and pathologies of inguinal canal was insignificant. Our research design was inadequate in showing long term gain. Additionally, results from group model creation could be affected by the dynamics amongst members. Future work should aim to address these issues.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 3","pages":"e42434"},"PeriodicalIF":3.4,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11849626/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human health risk from groundwater consumption: A case study in the Apaaso-Tafo Community in the Bono East Region of Ghana.","authors":"Emmanuel Okyere, Ethel Bentil, Nana Adwoa Kusi-Addai, Lawson Mensah","doi":"10.1016/j.heliyon.2025.e42460","DOIUrl":"https://doi.org/10.1016/j.heliyon.2025.e42460","url":null,"abstract":"<p><p>Water is a nutrient for life and a resource for human development, and therefore towns and cities often build treatment systems to provide wholesome water for consumption, bathing, washing, etc. For rural communities where centralised water treatment plants are lacking, groundwater (GW) is often the resource of choice due to its relatively low pathogenic loading and turbidity. However, GW is highly susceptible to contamination from anthropogenic activities. In the Bono East region of Ghana, 94 % of solid waste and 89 % of wastewater are disposed of on the roadside without treatment, posing a contamination risk to water resources. Despite the potential for GW contamination in the region, few researchers have assessed GW quality, and none has evaluated the human infectious risk from GW consumption. In this case study, GW quality in the Apaaso-Tafo community in the region was assessed and the infectious health risks posed to consumers were evaluated. Twenty GW samples were collected from ten boreholes. The concentrations of metals (Ca²⁺, Mg²⁺ and Fe) were determined using atomic absorption spectroscopy, bacteria (total and faecal coliform) using Multiple Tube Fermentation and Membrane Filter Techniques, and physicochemical qualities using electrometric, titrimetric, argentometric and spectrophotometric methods. The water quality indices (WQI) and the infection probability from drinking the GW were computed. The WQI showed that most (80 %) GW samples are within acceptable limits. Except for the pH, temperature, turbidity and total coliform bacteria, all parameters met the WHO standards. 40 % of the boreholes contained 50 to 500 cfu/100 mL of coliform bacteria and posed daily infection risks between 1 and 7.63 %. It is recommended that standpipes on boreholes be fitted with membrane or nano filters capable of removing bacteria and viruses to reduce infection risk. The authorities should also monitor GW quality regularly and respond to changes in quality with the appropriate intervention such as issuing 'boil-before-drinking' notices to consumers or encouraging parents to provide bottled and sachet water for their young children. Future research with an increased number of communities, sample size and sampling frequency should also be conducted to enhance the generalisability of these findings.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 3","pages":"e42460"},"PeriodicalIF":3.4,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11848078/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of calonysterone and 20-hydroxyecdysone effects in high-fat, high-sugar diet-induced obesity rat model.","authors":"Alaa Am Osman, Dávid Laczkó, Máté Vágvölgyi, Adrienn Seres-Bokor, Anita Sztojkov-Ivanov, Kata Kira Kemény, Attila Hunyadi, Eszter Ducza","doi":"10.1016/j.heliyon.2025.e42435","DOIUrl":"10.1016/j.heliyon.2025.e42435","url":null,"abstract":"<p><p>Globally, the incidence of obesity among adults has significantly risen since 1990, with a more than twofold rise in prevalence. Similarly, the incidence of obesity among adolescents has increased fourfold. Overweight constitutes a significant health and social issue in developed nations globally. Conventional therapies such as lifestyle modification (nutrition and physical activity) have limited weight reduction. Drug therapy is often not possible or cannot be afforded due to poor patient compliance or therapeutic side effects. 20-hydroxyecdysone (20E) is a worldwide used 'green anabolic' dietary supplement that has beneficial effects in some animal models of metabolic diseases. Our ongoing research examines the impacts of 20E and calonysterone (CAL) in an animal model with a diet high in fats and sugars (HFHSD). Glucose tolerance tests assessed prediabetic status and RT-PCR and Western blot analysis determined interleukin-6 (IL6) expression. The concertations of superoxide dismutase, catalase, adiponectin, leptin, and IL-6 were quantified by ELISA. Total antioxidant capacity was assessed using a colorimetric assay kit, and global DNA methylation was also measured. CAL entirely prevented HFHSD-induced obesity and decreased the inflammatory cytokine (IL6) level and antioxidant activity in our model. Both 20E and CAL normalized the changed plasma concentration of adiponectin and leptin after the HFHS diet. The administration of CAL and 20E in obese rats significantly increased the percent of total DNA methylation. This is the first in vivo study on this natural ecdysteroid, which may offer new alternatives for treating metabolic diseases. Based on our findings, we are supposed to show new preventive possibilities for overweight-induced chronic progressive diseases.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 3","pages":"e42435"},"PeriodicalIF":3.4,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11847253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing surface detection: A comprehensive analysis of various YOLO models.","authors":"G Deepti Raj, B Prabadevi","doi":"10.1016/j.heliyon.2025.e42433","DOIUrl":"https://doi.org/10.1016/j.heliyon.2025.e42433","url":null,"abstract":"<p><p>Material defects can significantly affect strength, durability and overall quality. Complex backgrounds and variations in steel surface images often hinder productivity and quality in industrial environments. Accurate defect detection becomes difficult due to small target size and unclear features. However, implementing accurate and automated object detection algorithms mitigates these challenges, allowing errors or defects to be detected before processing. Version 5 of You Only Look Once (YOLO), a precisely optimized learning model, has undergone extensive testing on steel strip datasets, providing effective solutions for recognition and detection in industry environments. This study presents an improved YOLOv5 detection model, exploiting the efficient channel attention (ECA) and coordinated attention (CoordAtt) mechanisms. Our results show notable improvements, with the ECA hybrid attention mechanism achieving 2-4 times faster inference times while maintaining high accuracy. Additionally, CoordAtt integration minimizes the parameter count by 25 % and gives higher accuracy on one of the datasets. Comparative analysis with YOLOv6, YOLOv7, and YOLOv8 demonstrates the superior accuracy of the enhanced YOLOv5 model on the NEU-DET and GC10-DET steel strip benchmark datasets, highlighting its effectiveness in detecting and timely recognition of actual defects.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 3","pages":"e42433"},"PeriodicalIF":3.4,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11849088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of vitamin D supplementation in patients with rheumatoid arthritis: A systematic review and meta-analysis.","authors":"Mahsa Ranjbar, Mehran Rahimlou, Maryam Fallah, Kurosh Djafarian, Hamed Mohammadi","doi":"10.1016/j.heliyon.2025.e42463","DOIUrl":"https://doi.org/10.1016/j.heliyon.2025.e42463","url":null,"abstract":"<p><strong>Background: </strong>Rheumatoid arthritis (RA) is known as an inflammatory illness. Evidence shows that Vitamin D modulates immunologic function and inflammation by affecting various immunological cells. We decided to run a systematic review and meta-analysis to investigate the relationship between vitamin D supplementation and the outcomes of adult patients suffering from RA.</p><p><strong>Methods: </strong>We searched electronic databases, using specific search terms in PubMed, Scopus, and ISI Web of Science, until May 2024. Clinical studies involving patients with RA were included if they compared the effects of vitamin D supplementation to either a placebo or standard care. The results from the selected studies were presented as weighted mean differences (WMD) along with a 95 % confidence interval (CI).</p><p><strong>Results: </strong>Inclusion criteria have been met by 11 studies and presented as part of this analysis. The results indicate a major influence of vitamin D supplementation on the Disease Activity Score 28 (DAS-28) (WMD: -0.83, 95 % CI: -1.38 to -0.28, p-value <0.001), C-reactive protein (CRP) level (WMD: -0.24, 95 % CI: -0.45 to -0.03, p-value = 0.03), erythrocyte sedimentation rate (ESR) level (WMD: -4.08, 95 % CI: -4.67 to -3.50, p-value <0.001), serum vitamin D level (WMD: 12.69, 95 % CI: 1.80 to 23.59, p-value = 0.02), and non-significant effect on the health assessment questionnaire (HAQ) and visual analog scale on pain (VAS-pain) scores. Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) assessment shows moderate certainty of the evidence for all outcomes except for serum vitamin D, which has a high certainty of the evidence.</p><p><strong>Conclusion: </strong>To improve DAS-28, CRP, ESR, and serum vitamin D in RA patients, vitamin D supplements may be beneficial, although the optimal dosage and length of treatment are still unknown.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 3","pages":"e42463"},"PeriodicalIF":3.4,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11849653/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}