Heliyon最新文献

{"title":"Construction for the useful classes of minimal circular neighbor designs: A comprehensive framework.","authors":"Khadija Noreen, Javid Shabbir, M H Tahir, Akbar Fardos, Rashid Ahmed, Olayan Albalwi","doi":"10.1016/j.heliyon.2025.e42446","DOIUrl":"https://doi.org/10.1016/j.heliyon.2025.e42446","url":null,"abstract":"<p><p>The primary source of bias in the estimation of treatment effect is neighbor effect which can occur in a variety of experiments. This kind of prejudice is reduced by the usage of neighbor balance designs. This article explains the logic behind developing the constructors by using the method of cyclic shifts, which yields sets of shifts for possible combinations of <i>v</i> and k to generate minimal circular balanced neighbor designs and their generalized classes when the effects of left-neighbor and right-neighbor are equal. These constructors make it simple to create a number of practical neighbor design classes. The process of creating the constructors will serve as the foundation for the researchers to create additional constructors for novel designs with additional crucial characteristics.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 3","pages":"e42446"},"PeriodicalIF":3.4,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11849069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accelerating the convergence of Newton's method for the Yang-Baxter like matrix equation.","authors":"Chacha Stephen Chacha","doi":"10.1016/j.heliyon.2025.e42425","DOIUrl":"https://doi.org/10.1016/j.heliyon.2025.e42425","url":null,"abstract":"<p><p>This article explores the application of exact line search and successive over-relaxation techniques to enhance the convergence of Newton method in solving the Yang-Baxter matrix equation for nontrivial numerical solutions. Moreover, the normwise, mixed, and componentwise condition numbers are derived to assess the sensitivity of solutions. Numerical experiments demonstrate that the exact line search method significantly improves convergence speed, particularly for larger matrices, by reducing both the number of iterations and residuals more effectively than the successive over-relaxation technique. Furthermore, the mixed and componentwise condition numbers consistently yield values close to one, indicating that the Yang-Baxter equation is well-conditioned. In contrast, the relatively high normwise condition numbers suggest an increased sensitivity to perturbations.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 3","pages":"e42425"},"PeriodicalIF":3.4,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11847052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reference intervals for thyroid-stimulating hormone in the adult Lebanese population: Results from the last decade.","authors":"Elie Naous, Riam Hijazi, Marianne Chalhoub, Nada El Ghorayeb, Marie-Hélène Gannagé-Yared","doi":"10.1016/j.heliyon.2025.e42453","DOIUrl":"https://doi.org/10.1016/j.heliyon.2025.e42453","url":null,"abstract":"<p><strong>Background: </strong>Thyroid Stimulating Hormone (TSH) is the most accurate marker in the assessment of thyroid function. Establishing a reference interval (RI) for TSH is essential for interpreting results of thyroid function tests. TSH RI in the Lebanese population using the indirect method is lacking. The aim of this study is to establish TSH RI according to age and gender, and to assess its trend over the last decade using the indirect method.</p><p><strong>Methods: </strong>TSH values of 80156 outpatient subjects (age range 18-99) were retrospectively collected between January 2011 and April 2021 from a tertiary university medical center in Beirut. TSH was measured using the same chemiluminescent assay (Immulite 2000).</p><p><strong>Results: </strong>The median TSH was 1.4 mIU/L (IQ 0.94-2.10). TSH RI was wider compared to the manufacturer one (0.31-4.95 mIU/L vs 0.40-4.0, p < 0.001). There was a decrease in lower reference limit (LRL) and an increase in upper reference limit (URL) with the increase in age categories (p < 0.001 for both comparisons). RI was broader in women compared to men (respectively 0.29-5.20 vs 0.35-4.48 mIU/L, p < 0.001). There are significant differences in the median, LRL and URL across the years and in all age categories (p < 0.001). TSH RI using the indirect method was wider than the direct method one (p < 0.001).</p><p><strong>Conclusion: </strong>Using the indirect method, TSH RI in the Lebanese population is wider than the manufacturers'one and that those obtained by the direct method and varies according to age, gender and over time. A periodic reevaluation of RI for each population should be done.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 3","pages":"e42453"},"PeriodicalIF":3.4,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11848085/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of stress distribution of CFRP bonded joints: A study of numerical and machine learning approach.","authors":"Shah Mohammad Azam Rishad, Md Ashraful Islam, Md Shahidul Islam","doi":"10.1016/j.heliyon.2025.e42440","DOIUrl":"https://doi.org/10.1016/j.heliyon.2025.e42440","url":null,"abstract":"<p><p>We aim to provide a study of material selection at the upper adherend subject for optimization of carbon fiber reinforced polymer (CFRP) adhesive-bonded joints with details on the stress distribution in the complex tri-material joint structure. The structure consists of a changing upper adhesive and CFRP lower adhesive, all bonded by a nano-thickness resin adhesive layer. The research, which analyzes almost 100 upper adherend substrates, hopes to answer how they influence stress distribution at the apex of a joint, a critical factor in bond strength. These results are essential in selecting the donor properties of the upper adherend in CFRP bonded joints. As this study also supports engineers and researchers in devising optimized machine learning models for addressing CFRP-bonded joint challenges, the accuracy of stress prediction is improved by applying machine learning techniques to the collected data more refinedly.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 3","pages":"e42440"},"PeriodicalIF":3.4,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11848103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pressure-dependent current transport in vertical BP/MoS₂ heterostructures.","authors":"Ofelia Durante, Sebastiano De Stefano, Adolfo Mazzotti, Loredana Viscardi, Filippo Giubileo, Osamah Kharsah, Leon Daniel, Stephan Sleziona, Marika Schleberger, Antonio Di Bartolomeo","doi":"10.1016/j.heliyon.2025.e42443","DOIUrl":"https://doi.org/10.1016/j.heliyon.2025.e42443","url":null,"abstract":"<p><p>van der Waals heterostructures between two-dimensional (2D) materials offer versatile platforms for innovative electrical device architectures and applications. Black phosphorus (BP) and molybdenum disulfide (MoS₂) emerge as promising candidates for heterostructures, owing to their exceptional electronic properties and gate-tunable capabilities. In this work, we study the electrical properties of a vertical BP/MoS₂ heterostructure fabricated onto a SiO₂/Si substrate in a back-gate configuration. We focus on the effect of air pressure, from atmospheric pressure to 10^-4 mbar, and show that best electrical performances are enabled at the lower pressure. The heterostructure exhibits gate-tunable rectifying current-voltage characteristics, with a rectification ratio close to 10³. The rectifying characteristics present a kink in the forward region revealing different conduction mechanisms, namely drift-diffusion and band-to-band tunneling. Furthermore, when used as a transistor, the device shows n-type conduction, high gate modulation with ON/OFF ratio of <math> <mrow><msup><mn>10</mn> <mn>6</mn></msup> </mrow> </math> , low off-state current of <math> <mrow><msup><mn>10</mn> <mrow><mo>-</mo> <mn>14</mn></mrow> </msup> <mspace></mspace> <mi>A</mi></mrow> </math> and mobility of 1.6 cm² V^-1 s^-1. The results of this work highlight the potential of BP/MoS₂ heterostructures for applications in low-power electronics, high-performance transistors, and sensitive pressure sensors.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 3","pages":"e42443"},"PeriodicalIF":3.4,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11848080/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple viral infections and antimicrobial use in hospitalized children with respiratory illness during pandemic and early post-pandemic era, Taiwan.","authors":"Chyi-Liang Chen, Yi-Ching Chen, Hsuan-Ling Hsiao, Yi-Jung Chang, Hsin-Chieh Li, Merve Arslan Aydin, Cheng-Hsun Chiu","doi":"10.1016/j.heliyon.2025.e42229","DOIUrl":"https://doi.org/10.1016/j.heliyon.2025.e42229","url":null,"abstract":"<p><strong>Background: </strong>Respiratory viral infections significantly burden pediatric populations. These infections are especially concerning in hospitalized children. Co-infection with bacteria may contribute to severe disease in children with respiratory viral infections.</p><p><strong>Methods: </strong>The trend of children's respiratory infections during and after the pandemic was analyzed. FilmArray RP was used for etiology surveys of hospitalized children with acute respiratory illness in a medical center in northern Taiwan from October 2022 to March 2023. Antimicrobial days of therapy (DOT) were used to measure and compare the antimicrobial consumption between FilmArray RP test-positive and -negative groups. We also reviewed Taiwan CDC's surveillance data in the study period.</p><p><strong>Results: </strong>Among 418 children tested, 271 cases showed positive results; 48.8 % (204/418) had a single virus identified. Multiple viruses were co-circulating in the community starting in September 2022. An increase in the number of influenza cases with severe complications in Taiwan was observed after October 2022. Following these viral infections, cases of invasive pneumococcal disease (IPD) began to increase from September 2022 onward. The FilmArray RP test results did not influence physicians' antibiotic prescribing, as there was no difference in DOT between the test-positive (single, double, or triple viruses-positive) and test-negative groups. However, the average DOTs in both groups were less than 10.</p><p><strong>Conclusions: </strong>Multiple viruses were co-circulating in the community after the pandemic likely due to immune debt. Pediatric physicians continued to use antibiotics for febrile symptoms in hospitalized children with respiratory illness, even when viral pathogens were identified.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 3","pages":"e42229"},"PeriodicalIF":3.4,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11848077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-performance electrochemical sensor based on Pt-Ag@Cu-BDC MOF composite modified glassy carbon electrode for detection of imidacloprid in citrus juice and water samples.","authors":"Fariba Hasani, Jahan Bakhsh Raoof, Reza Ojani, Milad Ghani","doi":"10.1016/j.heliyon.2025.e42438","DOIUrl":"https://doi.org/10.1016/j.heliyon.2025.e42438","url":null,"abstract":"<p><p>The key factor to improve the sensitivity of electrochemical sensors for direct detection, is the introduction of new nanomaterials with enhanced catalytic properties. Accordingly, we prepared Pt-Ag@Cu-metal organic framework (MOF) as a novel nanocomposite to construct a sensitive electrochemical sensor for voltammetric determination of imidacloprid (IMI). The copper benzene-1,4-dicarboxylate framework (Cu-BDC MOF) was used as support for bearing the metal nanoparticles (NPs) including Ag and Pt. First, Ag NPs were incorporated into Cu-BDC MOF and then Pt NPs were substitute through galvanic replacement reaction between Ag NPs and Pt ions. The Pt-Ag@Cu-BDC MOF as a novel nanocomposite was utilized as a modifier to decorate glassy carbon (GC) electrode. The excellent conductivity, hierarchical and micro-mesoporous structure of Pt-Ag@Cu-BDC MOF and the synergistic effect between Ag and Pt nanoparticles were beneficial for fast electron transfer required for IMI reduction. At the Pt-Ag@Cu-BDC MOF/GCE, reduction potential of IMI was greatly shifted to positive value and the electrochemical signal increased significantly. The prepared sensor exhibited wide linear range (5 nM-10000 nM), low detection limit (1.5 nM) and high sensitivity towards IMI detection. This sensor was successfully applied for detection of IMI in citrus juice and water samples with good recoveries (92-106 %, RSD ≤4 %).</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 3","pages":"e42438"},"PeriodicalIF":3.4,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11849624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reading motivation and reading comprehension achievement among English majors in China: A descriptive correlational study.","authors":"Lei Ma, Zheng Zhao","doi":"10.1016/j.heliyon.2025.e42427","DOIUrl":"https://doi.org/10.1016/j.heliyon.2025.e42427","url":null,"abstract":"<p><p>This study explores the relationship between reading motivation and reading comprehension achievement among English major students in China, an area that has received limited attention in existing literature. Drawing on previous research emphasizing the importance of reading motivation in improving reading skills, this study seeks to examine the connection between reading motivation and reading comprehension achievement within the specific research context. The Pearson correlation coefficient showed a significant positive correlation between reading motivation and reading proficiency among English major students at a Chinese private undergraduate university. The study also indicated that reading motivation can predict reading comprehension scores. This investigation not only fills a gap in current research but also paves the way for future experimental studies to investigate the efficacy of specific motivational interventions or instructional strategies in boosting reading motivation and subsequently improving reading skills among English language learners. The findings of this study are expected to guide educational practices and policies, ultimately leading to advancements in English language education for Chinese students majoring in English.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 3","pages":"e42427"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11849080/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the neuroprotective effects of <i>Dracocephalum moldavica</i> extract and its effect on metabolomic profile of rat model of sporadic Alzheimer's disease.","authors":"Marjan Talebi, Seyed Abdulmajid Ayatollahi, Mohammad Ali As'Habi, Farzad Kobarfard, Mona Khoramjouy, Farzaneh Niki Boroujeni, Mehrdad Faizi, Alireza Ghassempour","doi":"10.1016/j.heliyon.2025.e42412","DOIUrl":"10.1016/j.heliyon.2025.e42412","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is a progressive condition marked by multiple underlying mechanisms. Therefore, the investigation of natural products that can target multiple pathways presents a potential gate for the understanding and management of AD. This study aimed to assess the neuroprotective effects of the hydroalcoholic extract of <i>Dracocephalum moldavica</i> (DM) on cognitive impairment, biomarker changes, and putative metabolic pathways in a rat model of AD induced by intracerebroventricular streptozotocin (ICV-STZ). The DM extract was standardized and quantified based on examining total phenolic, total flavonoid, rosmarinic acid, and quercetin contents using colorimetry and high-performance liquid chromatography (HPLC) methods. The antioxidant potential of the extract was evaluated by 2,2-Diphenyl-1-picrylhydrazyl and nitric oxide radical scavenging assays. Male Wistar rats were injected with STZ (3 mg/kg, single dose, bilateral ICV) to induce a sporadic AD (sAD) model. Following model induction, rats were orally administered with DM extract (100, 200, and 400 mg/kg/day) or donepezil (5 mg/kg/day) for 21 days. Cognitive function was assessed using the radial arm water maze behavioral test. The histopathological evaluations were conducted in the cortex and hippocampus regions. Matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS) was used to assess metabolite changes in various brain regions. DM extract significantly attenuated cognitive dysfunction induced by ICV-STZ according to behavioral and histopathological investigations. Thirty-two discriminating metabolites related to the amino acid metabolism; the glutamate/gamma-aminobutyric acid/glutamine cycle; nucleotide metabolism; lipid metabolism (glycerophospholipids, sphingomyelins, ceramides, phosphatidylserines, and prostaglandins), and glucose metabolic pathways were identified in the brains of rats with sAD simultaneously for the first time in this model. Polyphenols in DM extract may contribute to the regulation of these pathways. After treatment with DM extract, 10 metabolites from the 32 identified ones were altered in the brain tissue of a rat model of sAD, most commonly at doses of 200 and 400 mg/kg. In conclusion, this study demonstrates the neuroprotective potential of DM by upregulation/downregulation of various pathophysiological biomarkers such as adenine, glycerophosphoglycerol, inosine, prostaglandins, and sphingomyelin induced by ICV-STZ in sAD. These findings are consistent with cognitive behavioral results and histopathological outcomes.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 3","pages":"e42412"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11840490/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative evaluation of management practices among large-scale broiler farms of Punjab, Pakistan.","authors":"Muhammad Tahir Amin, Muhammad Usman, Hafiz Muhammad Ishaq, Asad Ali, Muzamal Tariq, Mian Mubashar Saleem, Syed Ghulam Mohayud Din Hashmi, Kinza Saleem, Sohail Ahmad","doi":"10.1016/j.heliyon.2025.e42381","DOIUrl":"10.1016/j.heliyon.2025.e42381","url":null,"abstract":"<p><p>Limited research is available on the management practices of commercial broiler chicken production in Pakistan. Notably, the rapid expansion of environmentally controlled broiler farms in Punjab in recent years remains underexplored, with scarce information on this growing enterprise. The current study compared the management practices at 100 commercial broiler farms in Punjab, Pakistan, among different regions. A questionnaire was filled by on farm veterinarians (n = 100; one veterinarian from each farm) regarding the general information, infrastructure, biosecurity practices, visitor history, and production analysis of the surveyed poultry farms. The results of the survey revealed that the majority of the farms had environmentally controlled housing systems with rearing capacity of 75,000 broiler chickens or more; mostly having Cobb 500 and Ross 308 broiler strains. The infrastructure of >60 % of farms was found to be good with best biosecurity practices. The most commonly observed average downtime was 2-3 weeks plus washing with chlorinated water and detergent after dry cleaning at farms. The water quality regarding TDS and pH level was found normal at the majority of the farms. Traffic status was observed with random results at different farms, while in the Multan region, biosecurity practices were strict with no visits. The dead birds' removal time of 3-5 days was more common. Dead bird disposal through the pit method was more prevalent in most of the broiler farms across the Punjab. Better FCR, adjusted FCR, and market age were observed in broilers in the Multan area while those in the areas of Sheikhupura and Kasur showed poor performance due to improper management practices. It was concluded that effective management practices on broiler farms in Punjab, Pakistan, contribute to improved performance and bird health. Future studies are needed to explore this area further and develop strategies to address challenges faced by poultry farmers.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 3","pages":"e42381"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11847266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}