Heliyon最新文献

{"title":"Investigation the effect of calcination heating rate on the structural, morphological, thermal and color properties of nano Cobalt Aluminate (CoAl₂O₄).","authors":"Md Farid Ahmed, Monmon Podder, Md Rassel Moni, Md Lutfor Rahman, Bristy Biswas, Juliya Khanam, Mahmuda Hakim, Moksodur Rahman, Md Sahadat Hossain, Nahid Sharmin","doi":"10.1016/j.heliyon.2025.e42413","DOIUrl":"10.1016/j.heliyon.2025.e42413","url":null,"abstract":"<p><p>As the demand of ceramic ink is increasing rapidly for the decoration of good quality ceramic products in inkjet printing so the development of ceramic ink has become an urgent problem for ceramic industries. This study focuses on synthesizing Cobalt Aluminate (CoAl₂O₄), nanoparticles via sol-gel methods, utilizing different heating rate (1, 2, 3, 4, and 5°/min) during calcination. We investigate how these varying heating rates affect the properties of CoAl₂O₄ nanoparticles. This blue color Cobalt Aluminate is responsible for blue ceramic ink. Our findings highlight the significant impact of heating rate on shaping the characteristics of CoAl₂O₄ nanoparticles. Notably, increasing the heating rate triggers several noteworthy transformations. Powder X-ray diffraction (PXRD) analysis revealed sharper reflections and smaller crystallite sizes, indicative of enhanced crystallinity. The average crystallite size of the CoAl₂O₄ nanoparticles obtained by various peak profile analysis technique ranged 74.15-169.29 nm. Furthermore, dispersion stability in water was significantly improved with higher heating rates, a vital factor for various applications. The presence of functional groups was explored by Fourier Transform Infrared (FTIR) Spectroscopy, while Field Emission Scanning Electron Microscopy (FESEM) illustrated agglomerated nanoparticles showcasing diverse shapes. The average particle size of all the samples were measured by using ImageJ Software. These sizes ranged 73.48-39.55 nm. Energy Dispersive X-ray (EDX) Spectroscopy confirmed the purity of the composition, comprising cobalt, aluminum, and oxygen without any impurities. UV-visible spectrophotometry unraveled intriguing color changes associated with differing heating rates. As heating rates increased, a gradual shift towards less intense blue coloration (b∗ value ranged -19.77 to -17.64) was observed. The colorimetric data and the reflectivity measurement in the blue portion of the visible spectrum (400-492 nm) matched perfectly.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 3","pages":"e42413"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11847068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ni₁₂P₅ and Ni₁₂P₅-rGO for multifunctional electrocatalyst and supercapacitor application.","authors":"Anil M Palve, Omkar V Vani, Rishabh Srivastava, Wang Lin, Ram K Gupta","doi":"10.1016/j.heliyon.2025.e42414","DOIUrl":"10.1016/j.heliyon.2025.e42414","url":null,"abstract":"<p><p>Transition metal phosphides are crucial for various environmental and energy applications. In this study, porous Ni₁₂P₅ and Ni₁₂P₅-rGO were synthesized using a one-step solvothermal method. Red phosphorus served as the phosphorus source, while ethylene glycol acted as a capping agent to promote the formation of nanomaterials within a nitrogen-rich atmosphere. The catalytic performance of these materials was evaluated through their hydrogen evolution reaction (HER), oxygen evolution reaction (OER), and capacitance properties. Notably, Ni₁₂P₅-rGO exhibited Tafel slopes of 66 mV/dec for OER and 33 mV/dec for HER, indicating enhanced charge transfer efficiency compared to Ni₁₂P₅, which showed slopes of 78 mV/dec and 102 mV/dec, respectively. This improvement suggests that Ni₁₂P₅-rGO facilitates faster electron transfer, resulting in superior catalytic performance. Additionally, the synergistic effect of reduced graphene oxide (rGO) contributes to improved charge storage capabilities. The Ni₁₂P₅-rGO demonstrated a specific capacitance of 192 F/g, significantly higher than the 110 F/g observed for Ni₁₂P₅ at a current density of 1 A/g. Remarkably, these materials maintained their capacity over 5000 cycles, achieving a commendable 98 % coulombic efficiency. These findings highlight the potential of Ni₁₂P₅-rGO as an effective material for energy conversion and storage applications, showcasing its promising role in advancing the efficiency of related technologies.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 3","pages":"e42414"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11847079/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Appendiceal cancer in pregnancy and circulating tumor cells detection in the umbilical cord.","authors":"Risa Kudo, Kensuke Matsumoto, Tatsuya Ishiguro, Tomoyuki Sekizuka, Koji Nishijima, Takayuki Enomoto, Kosuke Yoshihara","doi":"10.1016/j.heliyon.2025.e42411","DOIUrl":"10.1016/j.heliyon.2025.e42411","url":null,"abstract":"<p><p>Although malignant tumors metastasizing to infant or the placenta are occasionally reported during pregnancy, the adverse effects of maternal malignant tumors on fetus have not been clarified. Due to the rarity of appendiceal cancer during pregnancy, the adverse effects of tumor on pregnancy have not been clarified. Herein, we report a 30-year-old woman who experienced appendiceal cancer (stage IVC) wherein metastatic ovarian tumor was detected during pregnancy. A bilateral salpingo-oophorectomy and partial resection of the omentum were performed at 25 weeks 6 days gestational age (GA), followed by Cesarean section at 30 weeks 1 day GA. Postpartum chemotherapy with fluorouracil, oxaliplatin, and levofolinate calcium could not sufficiently control her disease. Purpura was observed all over the infant body at birth. The neonatal disseminated intravascular coagulation score was 4 according to the scoring system used by the Japanese Society of Obstetrical, Gynecological & Neonatal Hematology, which meet the neonatal disseminated intravascular coagulation criteria. Detailed histopathological examination did not detect any cancer cells in the placenta or umbilical cord. Moreover, no other malignant abnormalities were found based on comprehensive medical evaluation of the infant. However, maternal circulating tumor cells (CTCs) were detected in both maternal and umbilical cord blood samples from the patient. Collectively, this case might be the first step into studying the circulation of CTCs through the umbilical cord via placenta and its effects on the fetal outcome; maternal malignant tumor worsened the fetal condition. More advanced analysis of CTCs in umbilical cord blood would be useful for predicting negative effects of maternal malignant tumor on infant in future.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 3","pages":"e42411"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11847105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adsorption characteristics of metronidazole on CoZr-LDH and its GO nanocomposite: Experimental and theoretical study.","authors":"Edris Jamshidi, Fateme Fathabadi, Faranak Manteghi, Rahime Eshaghimalekshah","doi":"10.1016/j.heliyon.2025.e42396","DOIUrl":"10.1016/j.heliyon.2025.e42396","url":null,"abstract":"<p><p>CoZr-LDH and its Graphene Oxide (GO) nanocomposite were synthesized by mechanochemical and hydrothermal methods, respectively, and were applied to absorb metronidazole as a pollutant antibiotic from an aqueous solution. In this study, Tetravalent and divalent metal cations were employed. The LDH and LDH/GO were characterized by SEM, EDS, IR, BET, and XRD analyses. In the adsorption process of metronidazole using both the CoZr-LDH and CoZr-LDH/GO nanocomposite as adsorbents, parameters such as initial solution pH, adsorbent dose, initial drug concentration, and contact time were optimized to obtain the maximum adsorption capacity. The adsorption performance of CoZr-LDH and its nanocomposite with graphene oxide (GO) was thoroughly investigated for the removal of metronidazole (MNZ), a significant environmental contaminant. CoZr-LDH demonstrated optimal adsorption, yielding an experimental qe value of 189.1376 mg g-1. Conversely, the CoZr-LDH/GO nanocomposite exhibited superior adsorption performance under optimum conditions, achieving a remarkable experimental qe value of 906.5688 mg g-1. The adsorption isotherms, including Langmuir, Freundlich, and Redlich-Peterson models, were fitted to the experimental data to describe the interaction mechanisms and surface characteristics. Additionally, kinetic studies involving pseudo-first-order and pseudo-second-order models were performed, revealing critical insights into the adsorption process. Post-adsorption characterization confirmed the successful interaction between MNZ and the adsorbents. This study emphasizes the potential of GO-enhanced CoZr-LDH for effective removal of metronidazole, addressing its status as a critical pollutant in wastewater. To comprehensively study the adsorption process in CoZr-LDH and CoZr-LDH/GO, theoretical analyses were conducted using Monte Carlo computational method. This approach, known for simulating numerous particle trajectories and statistical averaging, allowed for an in-depth examination of adsorption mechanisms under various conditions. The findings, validated against experimental data, enhanced model accuracy and provided deeper insights into adsorption behaviors in complex environments.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 3","pages":"e42396"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11847104/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of sustained-release extemporaneous moxifloxacin loaded commercial soft hydrogel contact lenses.","authors":"Duy Toan Pham, Pratthana Chomchalao, Kunasin Bunneramit, Phurichaya Kladcharoen, Rossukon Khotcharrat, Waree Tiyaboonchai","doi":"10.1016/j.heliyon.2025.e42436","DOIUrl":"10.1016/j.heliyon.2025.e42436","url":null,"abstract":"<p><p>Eye infections such as <i>Acanthamoeba</i> keratitis and bacterial keratitis are serious diseases that could lead to severe, sight-threatening complications. Although moxifloxacin eye drops (0.5 % w/v) is accepted for clinical treatments of these infections, the frequent administration is challenging to achieve the adequate dose due to the limitations of low ocular bioavailability and short retention time. To circumvent these issues, this study developed the extemporaneous moxifloxacin loaded commercial soft hydrogel contact lenses with sustained-release property. The simple soaking method was employed on five common available contact lenses of Acuvue, Biomedics, Maxim, Soflens, and Biotrue, which were immersed in the standard moxifloxacin eye drops solutions. Amongst them, three contact lenses (Acuvue, Biomedics, and Maxim) showed high drug loading of ∼2 mg and adequate controllable drug release for 24 h with Maxim possessing the highest release rate, and maintained the effective drug therapeutic level for at least 12 h. Kinetically, both the moxifloxacin loading and releasing processes followed the Higuchi model, with the diffusion mechanism governing the drug behaviors. Isothermally, the moxifloxacin molecules were adsorbed onto the contact lenses surfaces via physical adsorptions by weak interactions of van der Waals forces, ionic bonding, and hydrophobic interactions. Furthermore, both the eye drops brands (Moximac and Zomoxin), the loading pH (6.7 and 6.0), and the loading time (24 h and 2 h) had no significant effects on the loading and release of moxifloxacin, indicating the system versatility. Conclusively, the extemporaneous moxifloxacin loaded contact lenses, with a duration of action of at least 12 h, could be further explored to become a potential treatment for eye infections.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 3","pages":"e42436"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11847108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic and environmental contribution to phenotypic resemblance between Iranian couples: Tehran Cardiometabolic and Genetic Study (TCGS).","authors":"Parisa Riahi, Amir Hossein Saeidian, Albert Tenesa, Carolyn T Hogan, Michael March, Kamran Guity, Mahmoud Amiri Roudbar, Asieh Zahedi, Maryam Zarkesh, Farideh Neshati, Mehdi Hedayati, Fereidoun Azizi, Hakon Hakonarson, Maryam S Daneshpour, Mahdi Akbarzadeh","doi":"10.1016/j.heliyon.2025.e42401","DOIUrl":"https://doi.org/10.1016/j.heliyon.2025.e42401","url":null,"abstract":"<p><strong>Objective: </strong>To provide an applied framework for assessing the genetic contribution to assortative mating (AM) using height as a model trait and disclose the trace of certain pieces of evidence of AM in the form of the shared environmental effects from long-term cohabitation on spouses' anthropometric traits and lipid serum levels.</p><p><strong>Methods: </strong>2315 genotyped couples were extracted from the Tehran Cardiometabolic Genetic Study (TCGS). Pearson correlation analysis was used to assess the relationship between spouses' height. The GCTA-GREML was used to assess the SNP-based heritability of individual and spousal heights with AM adjustments. We used a recent GWAS meta-analysis of ∼5.4M individuals of height to calculate polygenic risk scores (PRS) for spouses' height. A subset of 1038 spouses out of 2315 couples were subsequently selected to enter the longitudinal resemblance, to be assessed in terms of their anthropometric traits and lipid serum levels in a 15-year follow-up. We conducted a Bayesian hierarchical meta-analysis for each time point to assess the validity of the increasing trend of the longitudinal association.</p><p><strong>Results: </strong>The correlation coefficient of height between spouses was estimated as r = 0.248. We found that a person's genotype determines 6.15 % of the variation in the spouse's height. Furthermore, correlation between PRS of individuals showed a statistical association between an individual's genotype and their spouse's genotype (R2 = 4 %) across 1,982 couples with only one genotyped spouse, achieving approximately half of the theoretical maximum accuracy. Long-term spousal resemblance revealed an increasing trend for correlation between husbands and wives in terms of their lipid serum level and obesity-related traits.</p><p><strong>Conclusion: </strong>Our findings support the AM hypothesis for height with a significant spousal correlation and show that selecting the spouse's height is genetically determined. Besides, we provide data showing that AM is predicted to result in a10 % increase in the heritability of height, which is related to the assortative nature of alleles in the population and not to the segregation of genetic variations. Finally, as one of the evolutionary consequences of AM, long-term spousal resemblance provided an increasing trend for correlation between spouses in terms of their lipid serum level and obesity-related traits.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 3","pages":"e42401"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11849086/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GA-Attention-Fuzzy-Stock-Net: An optimized neuro-fuzzy system for stock market price prediction with genetic algorithm and attention mechanism.","authors":"Burak Gülmez","doi":"10.1016/j.heliyon.2025.e42393","DOIUrl":"https://doi.org/10.1016/j.heliyon.2025.e42393","url":null,"abstract":"<p><p>This study introduces GA-Attention-Fuzzy-Stock-Net, a novel hybrid architecture that integrates genetic algorithms, attention mechanisms, and neuro-fuzzy systems for stock market price prediction. The research investigates the effectiveness of different architectural configurations, including variations in fuzzy layer membership functions (triangular, trapezoidal, Gaussian) and neural network architectures (1D ANN, 2D ANN, 1D LSTM, 2D LSTM). The model's performance is evaluated across multiple temporal horizons using sliding windows (5-day, 10-day, 20-day) to capture varying market dynamics. Genetic algorithms optimize the hyperparameters, including learning rates and network architectures, while the attention mechanism enhances the model's ability to focus on relevant temporal patterns. The study utilizes data from major technology stocks. Results demonstrate that GA-Attention-Fuzzy-Stock-Net consistently outperforms traditional machine learning approaches and baseline models across different evaluation metrics (MSE, MAE, MAPE, R2). The findings provide valuable insights for practitioners in financial markets and contribute to the advancement of hybrid intelligent systems for time series prediction. The model's superior performance is attributed to its unique integration of evolutionary optimization, attention-based feature selection, and fuzzy logic's ability to handle uncertainty in financial data.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 3","pages":"e42393"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11848073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CD163, a novel receptor for TNF, was revealed <i>in situ</i> by proximity ligation assay.","authors":"Alexandre Cousin, Myriam Oger, Aymar de Jenlis, Audrey Lejart, Laure Barbier, Diane Riccobono, Xavier Holy, Anne-Laure Favier, Krisztina Nikovics","doi":"10.1016/j.heliyon.2025.e42194","DOIUrl":"https://doi.org/10.1016/j.heliyon.2025.e42194","url":null,"abstract":"<p><p>Cytokine therapy utilizes cytokines to enhance the immune system to fight diseases. These strategies rely on advanced knowledge, including the communication between cytokines and their receptors. <i>In situ,</i> cytokine-receptor interactions are typically analyzed by co-localization using immunolabeling. Our study compared co-localization using the Proximity Ligation Assay (PLA), a recently developed <i>in situ</i> protein-protein interaction technique. In an inflamed porcine lung model, we demonstrated the efficacy of PLA in detecting interactions between tumor necrosis factor (TNF) and its receptors TNFR1 and TNFR2. Additionally, the CD163 receptor was identified as a novel partner of TNF. Furthermore, the combination of immunolabeling and PLA offered additional insights, particularly, the internalization of TNF following its binding with CD163 in macrophages. Our work focused on <i>in situ</i> interactions of TNF with macrophages TNF receptors and suggested exciting perspectives for further understanding and application of cytokine-based therapies.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 3","pages":"e42194"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11848091/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical implications of proximal tubular multicilia in glomerular diseases.","authors":"Bohye Kim, Boram Weon, Evonne Kim, Sohee Park, Wencheng Jin, Nayeon Shin, Yun Kyu Oh, Chun Soo Lim, Jung Pyo Lee, Obin Kwon, Jeonghwan Lee","doi":"10.1016/j.heliyon.2025.e42416","DOIUrl":"10.1016/j.heliyon.2025.e42416","url":null,"abstract":"<p><strong>Introduction: </strong>Multiciliated cells (MCCs) have been identified in the proximal tubules of patients with kidney disease; however, their clinical significance is unknown. We aimed to investigate whether MCCs are associated with clinical outcomes in patients with glomerular diseases.</p><p><strong>Methods: </strong>Between August 2012 and April 2021, 134 patients (including 126 with glomerular disease patients and 8 controls) who were hospitalized at Seoul National University Boramae Medical Center and Seoul National University Hospital were included in this study. The ratio of MCCs to total proximal tubular cells was calculated using immunohistochemistry. The relationship between the MCC ratio and kidney disease-related clinical features was then analyzed.</p><p><strong>Results: </strong>MCCs were exclusively detected in patients with glomerular diseases (68.3 %), not those in the control group. Patients with diabetic kidney disease (88.9 %) or antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis (GN, 86.4 %) had higher MCC ratios. MCC-positivity and MCC ratios were significantly associated with increased age and proteinuria, and a decreased estimated glomerular filtration rate (eGFR). Patients with higher MCC ratios had a significantly higher risk of end-stage kidney disease (ESKD) and composite outcomes with death. In multivariable analysis, MCC ratios were significantly correlated with an increased risk of ESKD (hazard ratio [HR], 1.413; 95 % confidence interval [CI], 1.012-1.972) and composite outcome (HR, 1.401; 95 % CI, 1.028-1.909).</p><p><strong>Conclusion: </strong>Higher MCC ratios were correlated with poorer prognosis; therefore, quantification of MCCs in the proximal tubules can serve as a valuable prognostic marker in clinical practice.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 3","pages":"e42416"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11847256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-sequence MRI-based nomogram for prediction of human epidermal growth factor receptor 2 expression in breast cancer.","authors":"Mengyi Shen, Li Zhang, Dingyi Zhang, Xin He, Nian Liu, Xiaohua Huang","doi":"10.1016/j.heliyon.2025.e42398","DOIUrl":"10.1016/j.heliyon.2025.e42398","url":null,"abstract":"<p><strong>Objective: </strong>To develop a nomogram based on multi-sequence MRI (msMRI) radiomics features and imaging characteristics for predicting human epidermal growth factor receptor 2 (HER2) expression in breast cancer (BC).</p><p><strong>Methods: </strong>206 women diagnosed with invasive BC were retrospectively enrolled and randomly divided into a training set (n = 144) and a validation set (n = 62) at the ratio of 7 : 3. Tumor segmentation and feature extraction were performed on dynamic contrast-enhanced (DCE) MRI, T2-weighted imaging (T2WI), and apparent diffusion coefficient (ADC) map. Radiomics models were constructed using radiomics features and the radiomics score (Rad-score) was calculated. Rad-score and significant imaging characteristics were included in the multivariate analysis to establish the nomogram. The performance was mainly evaluated via the area under the receiver operating characteristic curve (AUC).</p><p><strong>Results: </strong>Edema types on T2WI (OR = 4.480, <i>P</i> = 0.008), enhancement type (OR = 7.550, <i>P</i> = 0.002), and Rad-score (OR = 5.906, <i>P</i> < 0.001) were independent imaging predictors for HER2 expression. Radiomics model based on msMRI (including DCE-MRI, T2WI, and ADC map) had AUCs of 0.936 and 0.880 in the training and validation sets, respectively, exceeding the AUCs of one sequence or dual sequences. With the combination of edema and enhancement types, the nomogram achieved the highest performance in the training set (AUC: 0.940) and validation set (AUC: 0.893).</p><p><strong>Conclusion: </strong>The developed multi-sequence MRI-based nomogram presents a promising tool for predicting HER2 expression, and is expected to improve the diagnosis and treatment of BC.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 3","pages":"e42398"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11847282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}