Heliyon最新文献

{"title":"Yeast cells experience chronological life span extension under prolonged glucose starvation.","authors":"Setu Mallick, Atia Shanjida Shormi, Hawa Jahan, Mohammad Shamimul Alam, Rowshan Ara Begum, Rakha Hari Sarker, Khandaker Ashfaqul Muid","doi":"10.1016/j.heliyon.2025.e42898","DOIUrl":"10.1016/j.heliyon.2025.e42898","url":null,"abstract":"<p><p>Budding yeast, <i>Saccharomyces cerevisiae,</i> is an ideal model organism for genetic research due to its similarity in life cycle and cellular structure to higher eukaryotes as well as its ease of cultivation and manipulation in the laboratory. Yeast cells benefit from being cultured in calorie-restricted media, which can be achieved by reducing glucose concentration from 2 % to 0.5 %. Cell metabolism depends on glucose and therefore, affects the physiology of the cell. This study aimed to investigate the effects of long-term glucose starvation on the lifespan of yeast cells by culturing in both standard and glucose-starved conditions. In this investigation yeast cells (BY4743 strain) were cultured in glucose-restricted YPD media (0.5 percent dextrose) to assess lifespan, growth-proliferation, autophagy, apoptosis, mtDNA abundance. The findings revealed that prolonged glucose restriction significantly extended chronological lifespan in yeast (p < 0.05). In order to decipher how starved yeast live chronologically longer, we tested mitochondrial association and found that calorie deprivation lowered the rate of mtDNA spontaneous mutation and increased mtDNA abundance which is a suggestive sign of mitobiogenesis. Furthermore, cells cultured on glucose-restricted media led to more autophagosome formation but less cell death. These results suggested that glucose restriction can enhance lifespan by improving overall cellular conditions. These findings may serve as a foundation for future research in aging, cancer and diabetes.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42898"},"PeriodicalIF":3.4,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11894305/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>In silico</i> discovery of potential novel anti-tuberculosis drug candidates from phytoconstituents of <i>Chlorophytum borivilianum</i> and <i>Asparagus racemosus</i>.","authors":"Munir Ibrahim, Asmita Detroja, Avani Bhimani, Tirth Chetankumar Bhatt, Jaykumar Koradiya, Gaurav Sanghvi, Ashok Kumar Bishoyi","doi":"10.1016/j.heliyon.2025.e42859","DOIUrl":"10.1016/j.heliyon.2025.e42859","url":null,"abstract":"<p><p>Tuberculosis (TB), caused by <i>Mycobacterium tuberculosis</i>, remains a significant global health challenge, particularly in developing nations. Side effects and increasing drug resistance often limit conventional pharmaceutical treatments for TB. This has highlighted the urgent need for novel therapeutic agents. Traditional medicine offers a promising avenue for discovering effective and safer alternatives. <i>In silico</i> approaches play a crucial role in pharmaceutical research by facilitating the identification of novel therapeutic compounds. These techniques are widely employed to explore potential treatments for diverse diseases. This study aims to identify lead molecules with anti-tuberculosis potential that could be further studied for their inhibitory potential and possible optimization for the treatment of tuberculosis. <i>Chlorophytum borivilianum</i> and <i>Asparagus racemosus</i> were selected for their diverse phytochemical profiles and proven pharmacological activities, including significant antimicrobial properties that make them promising candidates for in silico exploration of anti-tuberculosis therapeutics. The drug-likeness and pharmacokinetics of phytochemicals from the plants were evaluated using Lipinski's rule of five, and ADMET predictions. Phytochemicals meeting these criteria were subjected to molecular docking against <i>Mycobacterium tuberculosis</i> targets: CYP51, InhA, and EthR, using Vina (PyRx)platform to calculate binding affinities and assess interaction stability. Molecular dynamics simulations (100 ns) were performed to validate the stability of the docked complexes, focusing on key parameters such as RMSD, RMSF, and Rg. This approach identified hecogenin, sarsasapogenin, and isoflavone as potential inhibitors of CYP51 with high binding affinities and stable interactions, suggesting their promise as lead compounds for tuberculosis treatment.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42859"},"PeriodicalIF":3.4,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903821/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of clonal hematopoiesis of indeterminate potential with myocardial characteristic differences in non-ischemic heart failure.","authors":"Jooyeon Lee, Yoo Jin Hong, Jin-Ho Park, Su-Yeon Choi, Chansub Lee, Choonghyun Sun, Hongyul An, Youngil Koh, Se-Eun Kim, Jaewon Oh, Seok-Min Kang, Chan Joo Lee, Young-Jin Kim","doi":"10.1016/j.heliyon.2025.e42858","DOIUrl":"10.1016/j.heliyon.2025.e42858","url":null,"abstract":"<p><p>Clonal hematopoiesis of indeterminate potential (CHIP) is an aging process associated with the prognosis in heart failure (HF), regardless of etiology. This study investigated the association between CHIP and myocardial tissue characteristics in patients with non-ischemic HF. We enrolled 95 patients diagnosed with non-ischemic HF with a left ventricular ejection fraction (LVEF) of ≤40 % who underwent cardiac magnetic resonance imaging (MRI) within 3 months of diagnosis. Next-generation sequencing was performed to determine the presence of CHIP-related mutations. Transthoracic echocardiography was performed to evaluate left ventricular reverse remodeling. CHIP was identified in 15 patients. Patients with CHIP-mutation had higher native T1, extracellular volume fraction, and late gadolinium enhancement quantification (LGE). After adjusting for age and sex, CHIP mutations remained as contributing factors to the differences in cardiac MRI mapping values. However, no difference was observed in left ventricular reverse remodeling by CHIP within 1 year. This study demonstrated CHIP's association with higher mapping values and LGE on cardiac MRI. However, its impact on short-term LV reverse remodeling in non-ischemic HF patients was attenuated, indicating the need for further research on its long-term effect.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42858"},"PeriodicalIF":3.4,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11904585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards preventing the false alarms in indoor physical intrusion detector system and the incorporation of intruder immobilizer system.","authors":"Uzoma Ifeanyi Oduah, Daniel Oluwole, Samuel Olamilekan Johnson","doi":"10.1016/j.heliyon.2025.e42855","DOIUrl":"10.1016/j.heliyon.2025.e42855","url":null,"abstract":"<p><p>Indoor physical intrusion detector systems are rendered ineffective and inefficient if the frequency of false alarms is high. The sensor technology deployed and the sensor architecture implemented determines the sensitivity of the intrusion alarm systems and the rate of false alarms. Here we report the development of an innovative smart reliable, easily deployable, indoor physical intrusion detector and intruder immobilizer system for security applications. The developed device implements two ultrasonic sensors positioned strategically apart and combined by AND logic gate to detect only intruders and preventing false triggers. A gas canister containing lachrymatory agents is connected to the circuit in such a manner that a solenoid switch activates the discharging of the gas upon the enabling of the circuit when an intruder is detected. Through this arrangement, the intruder is rendered immobile and harmless before apprehension. The device also activates an alarm simultaneously to alert the users. The developed device creates a secured environment and is suitable for homes, apartments, banks, warehouses, supermarkets especially in low income countries of Africa.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42855"},"PeriodicalIF":3.4,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11904523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global trends in gallbladder cancer survival: A 30-year analysis of cancer registry data.","authors":"Yu-Xuan Xiao, Jun Chen, Zhuo-Ying Li, Yi-Xin Zou, Xiao-Hui Zhou, Wei Zhang, Hong-Lan Li, Evelyne Y Bischof, Yong-Bing Xiang","doi":"10.1016/j.heliyon.2025.e42853","DOIUrl":"10.1016/j.heliyon.2025.e42853","url":null,"abstract":"<p><strong>Background: </strong>Gallbladder cancer has historically been characterized with a poor prognosis. This study aims to describe the global patterns and temporal trends in gallbladder cancer survival using data from cancer registries.</p><p><strong>Methods: </strong>We conducted a systematic review by searching six databases-PubMed, Web of Science, EMBASE, SEER, CNKI, and Wanfang-for using of registry-based data published before January 1, 2024. Survival data were carefully extracted and analyzed from the final set of included studies.</p><p><strong>Results: </strong>Among the 55 studies included, more than 320,000 people, suggest that survival improvements for gallbladder cancer have stagnated over the past three decades. No significant improvements in 5-year relative survival rates were observed worldwide. After age standardization, the highest 5-year relative survival rate is 30.6 % (Changzhou, China, 2011-2013 and Korea, 2013-2019), while the lowest is 6.0 % (Austria, 1990). The 5-year relative survival rate for gallbladder cancer was generally higher in Asian populations than in other regions. Survival rates were more favorable in younger individuals, with no differences in survival observed between the sexes.</p><p><strong>Conclusions: </strong>Over the past 30 years, the prognosis of patients with gallbladder cancer has not improved significantly worldwide. There is an urgent need for new treatments for gallbladder cancer as well as simple and effective screening methods to improve the survival rate of gallbladder cancer.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42853"},"PeriodicalIF":3.4,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11894304/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive review of dynamical simulation models of packed-bed systems for thermal energy storage applications in renewable power production.","authors":"D Pérez-Gallego, J Gonzalez-Ayala, A Medina, A Calvo Hernández","doi":"10.1016/j.heliyon.2025.e42803","DOIUrl":"10.1016/j.heliyon.2025.e42803","url":null,"abstract":"<p><p>The need for large-scale energy storage in the context of renewable electricity production worldwide is evident. Among the various energy storage methods, thermal energy storage stands out. It is independent of geographical location, allows high storage capacities, does not require scarce materials, and is cheaper than its direct competitors. Currently, several technologies are being intensively developed. In some of them, packed-bed systems play a central role: a heat transfer fluid heats up or releases heat from a porous solid that acts as a thermal energy reservoir. This work compiles their application to concepts such as concentrated solar power, pumped thermal energy storage, and compressed or liquid air energy storage. Different physical models with diverse refinement degrees and the corresponding computational schemes are comprehensively presented. Comparison with previous experimental works includes gas or liquid heat transfer fluids, sensible or latent heat transfers, and a wide range of temperature levels. It is shown that the continuous 1D solid phase model solved with an implicit Euler method provides satisfactory results with a reasonable computing time for various systems. The influence of time step and spatial mesh is surveyed, as well as that of pressure drops. Efficiencies and stored energies are calculated for some particular cases, and sensitivity analysis is presented, including parameters such as fluid velocity in discharge and storage time. Concerning the latter, discharge efficiencies for long-time storage (between 10 and 15 h) are fairly good, between 0.39 and 0.20.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42803"},"PeriodicalIF":3.4,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11891709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative fault diagnostic analytics in transformer windings: Leveraging logistic regression, discrete wavelet transform, and neural networks.","authors":"Salman Baroumand, Ali Reza Abbasi, Mohammadreza Mahmoudi","doi":"10.1016/j.heliyon.2025.e42872","DOIUrl":"10.1016/j.heliyon.2025.e42872","url":null,"abstract":"<p><p>Protection of transformers is crucial in the power industry due to their susceptibility to various electrical and mechanical faults over time. Traditional methods like Frequency Response Analysis (FRA) have limitations in accurately diagnosing these faults. This paper highlights the potential of combining advanced signal processing techniques with machine learning algorithms by presenting an innovative hybrid model for accurately detecting transformer winding faults, utilizing Logistic Regression, Artificial Neural Networks (ANN) and Discrete Wavelet Transform (DWT). The primary novelty of this approach lies in the use of Logistic Regression to evaluate the impact of each wavelet decomposition, which aids in selecting the most effective wavelet bases, reducing data volume, and decreasing computational complexity. By integrating these methods, the proposed model significantly enhances fault detection accuracy and system performance. The effectiveness of the algorithm is validated through a practical case study, demonstrating a 97 % success rate in detecting transformer faults and reducing misclassification to 2.9 %.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42872"},"PeriodicalIF":3.4,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903824/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrophysiological characteristics of neuropathic pain model in mice and a technique to evaluate peripheral nerve damage in the sciatic nerve.","authors":"Hidenori Suzuki, Masahiro Funaba, Sayaka Ogi, Kosei Matsumoto, Norihiro Nishida, Kazuhiro Fujimoto, Takashi Sakai, Kenji Nishikawa","doi":"10.1016/j.heliyon.2025.e42879","DOIUrl":"10.1016/j.heliyon.2025.e42879","url":null,"abstract":"<p><strong>Background: </strong>Experimental neuropathic pain (NP) models were developed from peripheral injuries and are widely used for pain research. However, previously published methods and outcomes in the evaluation of sciatic nerve dysfunction vary widely across each report. In this study, we established the electrophysiological analysis of sensory nerve action potentials (SNAPs) and compound motor action potentials (CMAPs) as objective methods for evaluating sciatic nerve dysfunction and revealed the electrophysiological characteristics of NP mice models.</p><p><strong>Methods: </strong>We used male C57BL/6 J mice, C57BLKS/J lar- + Leprdb/+Leprdb (db/db) mice, and mouse models of paclitaxel-induced NP and spared nerve injury (SNI) surgery (10 mice in each group). For nerve conduction studies, we used evoked potential/electromyography apparatuses and bipolar electrodes as stimulating and recording electrodes for SNAPs and CMAPs. SNAPs were recorded from the sciatic nerve. For the distal motor latency and CMAPs amplitude measurements, we placed the cathode of the recording electrode on the gastrocnemius muscle.</p><p><strong>Results: </strong>In electrophysiological assessments, the SNI model showed the most severe sensory disturbance in SNAP with allodynia in the sciatic nerve. The db/db model showed moderate sensory disturbance with allodynia, whereas the paclitaxel model showed slight sensory disturbance but also with allodynia. Only the SNI model showed significantly lower amplitudes of CMAPs than those of normal mice, whereas the paclitaxel and db/db models showed sensory disturbance but no loss of motor function.</p><p><strong>Conclusions: </strong>We focused on the detailed methodology of electrophysiological assessment in experimental NP models. Our method of electrophysiological analysis of SNAPs and CMAPs of the sciatic nerve was well reflected in the pain withdrawal tests performed in each NP model and may be useful for future research of NP in experimental NP models.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42879"},"PeriodicalIF":3.4,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11904491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic integration of energy harvesters and supercapacitors for enhanced performance.","authors":"Mariya Aleksandrova, Ivaylo Pandiev","doi":"10.1016/j.heliyon.2025.e42808","DOIUrl":"10.1016/j.heliyon.2025.e42808","url":null,"abstract":"<p><p>In this paper, it is integrated a piezoelectric energy harvester and a supercapacitor storage device on a flexible substrate with a connection through an innovative alternative current (AC) to direct current (DC) boosting power management system for wearable biosensors' power supply. Flexible substrates can conform to irregular surfaces or shapes, enabling energy harvesting and storage devices to be integrated into a variety of form factors, including curved or bendable surfaces. Having an integrated energy harvester and storage system ensures a reliable and portable power source, providing power autonomy. The proposed element was layer-by-layer design including silver electrode, polyvinylidene fluoride-trifluoroethylene/multiwall carbon nanotubes, poly(3,4-ethylenedioxythiophene) polystyrene sulfonate: carbon nanotubes, aluminium oxide, graphene and poly(3,4-ethylenedioxythiophene) polystyrene sulfonate: carbon nanotubes (Ag/PVDF-TrFE:MWCNT/PEDOT:PSS:CNT/Al₂O₃/Gr/PEDOT:PSS:CNT), prepared by spray coating. A voltage rectifier with a low-pass filter and a direct current to direct current (DC-DC) converter was used as a power management system and intermediate unit between the harvester and storage part of the element. The type of the electronic circuit is voltage-doubler rectifier. It was found that piezoelectric harvester can generates voltage with a magnitude of 2V at loading of 110 g/cm²@10 Hz and with the proposed electronic circuit can be determined the workability of the created element during repeated charging and discharging, without introducing interfering changes in the capacity. The behaviour of the supercapacitor part is dependent on the thickness of Al₂O₃ and demonstrates more favourable characteristics at the thicker film of 750 nm, where the charging time is short (6s), the voltage ripples are small (±0.50 mV), and the maximum output voltage after charging almost reached the input supply voltage (∼1.94 V output voltage at 2 V input voltage). In addition, it resists up to 15500 cycles and shows a stable retention capacitance of 1.63 mF. The devices retain their capacity at multiple bending (1000) to 93 % and 91 %, according to the aluminium oxide film thickness, which is suitable for wearable devices.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42808"},"PeriodicalIF":3.4,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11904531/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How do energy price, energy-saving policies, and crisis affect energy-saving behavior?","authors":"Dat Ngoc Nguyen, Duy Van Nguyen, Dat Dinh Nguyen, Thuy Trong Than, Loc Xuan Tran","doi":"10.1016/j.heliyon.2025.e42787","DOIUrl":"10.1016/j.heliyon.2025.e42787","url":null,"abstract":"<p><p>In order to reduce CO2 emissions into the environment, energy conservation is considered a long-term strategy. To encourage people to save energy, the government may need to implement certain policies. Vietnam is a developing country dependent on fossil fuels and heavily affected by climate change. At the same time, there has been no research evaluating the impact of energy prices, government policies, and crises on energy-saving behavior in Vietnam. Therefore, this study uses the theory of planned behavior, technological acceptance behavior, and social exchange to evaluate these relationships. This research will answer the keys research question such as how would the policies which related to price, energy-saving activities effect on energy-saving behavior of households; How would a crisis like covid-19 affect energy-saving behavior? The research conducted surveys and analysis on 1166 respondents. The results of the PLS-SEM model analysis indicate that energy-saving policies do not directly affect the intention to save energy but have a positive impact on energy-saving behavior. Both energy prices and crises have a positive impact on both the intention and behavior of energy-saving. The study has made a significant contribution to the theory by confirming the existence of social exchange theory and the protection motivation theory in explaining energy-saving behavior.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42787"},"PeriodicalIF":3.4,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11904500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}