Heliyon最新文献

{"title":"Unified resilience model using deep learning for assessing power system performance.","authors":"Volodymyr Artemchuk, Iurii Garbuz, Jamil Abedalrahim Jamil Alsayaydeh, Vadym Shkarupylo, Andrii Oliinyk, Mohd Faizal Bin Yusof, Safarudin Gazali Herawan","doi":"10.1016/j.heliyon.2025.e42802","DOIUrl":"10.1016/j.heliyon.2025.e42802","url":null,"abstract":"<p><p>Energy resilience in renewable energy sources dissemination components such as batteries and inverters is crucial for achieving high operational fidelity. Resilience factors play a vital role in determining the performance of power systems, regardless of their operating environment and interruptions. This article introduces a Unified Resilience Model (URM) using Deep Learning (DL) to enhance power system performance. The proposed model analyzes environmental factors impacting the resilience of batteries and energy storage devices. This deep learning approach trains performance-impacting factors using previously known low resilience drain data. The learning output is utilized to augment various strengthening factors, thereby improving resilience. Drain mitigation and performance improvements are combined for direct impact verification. This process validates the model's fidelity in enhancing power system performance, with a specific focus on the impact of weather factors.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42802"},"PeriodicalIF":3.4,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11891688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overexpressed Wnt-7a acts as a potential antitumor immune modulator and predicts poor prognosis in HNSCC.","authors":"Hui-Chao Jiang, Ya Gao, Shu-Yan Wang, Yong-Lan Zhao, Hai-Peng Sun","doi":"10.1016/j.heliyon.2025.e42794","DOIUrl":"10.1016/j.heliyon.2025.e42794","url":null,"abstract":"<p><p>Immune checkpoint inhibitor (ICI) has become the first-line treatment of advanced head and neck squamous cell carcinoma (HNSCC), which has a relatively poor clinical prognosis and high mortality. However, only a proportion of patients respond well to ICI therapy. Identifying reliable predictive markers and potential targets to enhance the efficacy of ICI is of great importance. In this study, we systematically screened potential genes related to poor prognosis in HNSCC and Wnt-7a was selected based on results from multiple databases. Wnt-7a was overexpressed in HNSCC tissues and was associated with shorter overall survival. Human tissue samples and further bioinformatic analysis showed that Wnt-7a may be expressed in T cells and inhibited the infiltration and function of cytotoxic T cell response, both directly and indirectly through decrease the infiltration of Th1, Th17 cells and increasing the infiltration of Tregs. Genes that can directly interact with Wnt-7a were also identified. Surprisingly, 8 out of 9 genes identified were found to participate in the modulation of anti-tumor immunity. In addition, our study suggested that Wnt-7a, as a canonical Wnt ligand, could exert its function via regulating Wnt signaling and related mechanisms. Taken together, these results strongly support that Wnt-7a is a strong predictor of prognosis and ICI efficacy, and could be a promising potential target for enhancing the therapy response.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42794"},"PeriodicalIF":3.4,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical outcome of cerebellopontine angle meningiomas via a retrosigmoid approach: A single-center experience in Vietnam.","authors":"Hong-Hai Do, Luan Trung Nguyen Dao, Minh-Anh Nguyen, Thanh-Lam Nguyen","doi":"10.1016/j.heliyon.2025.e42860","DOIUrl":"10.1016/j.heliyon.2025.e42860","url":null,"abstract":"<p><strong>Objectives: </strong>Evaluate the surgical results of cerebellopontine angle (CPA) meningiomas via a retrosigmoid approach.</p><p><strong>Methods: </strong>This study investigated the outcomes of the retrosigmoid approach for CPA meningiomas in 36 patients. Demographic characteristics and surgical outcomes were recorded on admission, post-operation for 3-month, and 12-month follow-up. Surgical outcome was measured by using the Glasgow Outcome Scale (GOS), the extent of resection (EOR), and cranial nerve functions. Statistical analysis was conducted to identify the factors influencing outcomes.</p><p><strong>Results: </strong>The data showed 69.4 % of the patients had a tumor with a size over 30 mm. Intraoperatively, the most common site of dural attachment was supra-meatal (33.3 %) and only one patient had a tumor centered on internal acoustic meatus (IAM). Gross total resection was achieved in 25 patients (69.4 %). Good functional status (GOS 4-5) at discharge was 77.8 % and at 12-month follow-up was 88.9 %. Large tumors (>30 mm) with brainstem compression, brainstem edema, flow-void within tumor, and invasion of cranial foramina (Meckel's cave, jugular foramen) significantly impacted the outcome (p < 0.05). Tumors invading the IAM were associated with a significantly higher risk of facial palsy compared to those without IAM involvement. Besides, aspiration pneumonia was strongly related to poor outcomes (p < 0.05).</p><p><strong>Conclusion: </strong>Most CPA meningiomas can safely be resected via a retrosigmoid approach, highlighting the importance of meticulous surgical technique and post-operative care. However, careful consideration of factors like tumor size, flow-void within tumor, brainstem compression, brainstem edema, and potential complications (due to invasion of cranial foramina) can help optimize surgical strategy and improve long-term functional outcomes.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42860"},"PeriodicalIF":3.4,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11904476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A formal statechart model of immediate neonatal adaptation guidelines.","authors":"Edgar Hernando Sepúlveda-Oviedo, Leonardo Enrique Bermeo Clavijo, Luis Carlos Méndez-Córdoba","doi":"10.1016/j.heliyon.2025.e42784","DOIUrl":"10.1016/j.heliyon.2025.e42784","url":null,"abstract":"<p><p>Research highlights the importance of applying physiological criteria for optimal umbilical cord clamping, underlining its lasting advantages. In response, the Division of Pediatrics, Perinatology, and Neonatology at the National University of Colombia has pioneered the Immediate Neonatal Adaptation Guideline, focusing on Physiologically-based Cord Clamping. This study has two main objectives: The first is to represent the medical guideline through a statechart model to enhance clarity and detail. Secondly, to evaluate the effectiveness of statechart models in depicting medical guidelines for educational and training purposes within a human-centric framework. In this study, a group of medical professionals and engineers designed the statechart model for the Immediate Neonatal Adaptation guideline through a progressive refinement method. The model comprises 20 states, 38 events, and 4 superstates, offering clear visual language for its evaluation by an interdisciplinary panel of engineers and health professionals. This visual representation facilitates a more explicit identification of patient states, criteria, and clinical indicators involved in the procedure. Feedback indicates general satisfaction with the <i>Versatility, Usability, Scalability</i> and <i>Moderate visual complexity</i> of the model.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42784"},"PeriodicalIF":3.4,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11891693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and evaluation of BDNF-loaded PCL/PVA two-layer nerve guidance conduit with enhanced biomechanical and biological properties for peripheral nerve regeneration.","authors":"Massoumeh Jabbari Fakhr, Mohsen Eslami Farsani, Leyla Fath-Bayati, Reihaneh Seyedebrahimi, Mehdi Sadrjahani, Fatemeh Kavakebian, Alireza Rezapour","doi":"10.1016/j.heliyon.2025.e42792","DOIUrl":"10.1016/j.heliyon.2025.e42792","url":null,"abstract":"<p><p>The repair of damaged peripheral nerves and the following restoration of functionality remain significant therapeutic challenges. Hollow nerve conduits currently available do not align with the ideal human model. Successfully mending nerve gaps requires incorporating biomimetic and functional features into neural conduit design. In this research, a new two-layer conduit that combines topographic support and controlled growth factor release was developed. We used a two-layered framework to amplify the mechanical reinforcement and reduce the risk of tissue collapse post-grafting. The hollow nerve conduits were fabricated through three-dimensional printing, employing Polycaprolactone (PCL) and a slowly biodegradable nanofiber for the intraluminal brain-derived neurotrophic factors (BDNF)-loaded polyvinyl alcohol (PVA)/PCL core-shell. The contact angle was indicated to show the hydrophilicity properties and degradation rate for biocompatibility. The scanning electron microscope <b>(</b>SEM) images were analyzed to determine the fiber's diameters, structure morphology, and stem cell adhesion. The performance of core-shell conduits was investigated in human dental pulp stem cells <b>(</b>hDPSC) culture and their differentiation into Schwann cells (SCs) <i>invitro</i>. The vitality of samples was assessed using SEM, MTT assay, and differentiation potential with real-time and Immunofluorescence staining techniques. <i>Invitro</i> cumulated BDNF release followed the Korsmeyer-Peppas model, demonstrating a strong correlation coefficient of 0.981. Real-time analysis showed that after 14 days of induction, the expression of S100 increased 5.89-fold. We concluded that core-shell PCL/PVA nerve guidance conduits can encourage the adhesion and proliferation of hDPSCs and create the ideal environment for increasing cell survival. Also, the sustained release of BDNF within conduit walls promoted differentiation toward SC.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42792"},"PeriodicalIF":3.4,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11891681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of COVID-19 on the achievement of public school students in British Columbia: A multilevel analysis on the results from the province-wide standardized assessment.","authors":"Fubiao Zhen","doi":"10.1016/j.heliyon.2025.e42851","DOIUrl":"10.1016/j.heliyon.2025.e42851","url":null,"abstract":"<p><p>This study aims to investigate the impact of COVID-19 on public school students' achievement by collecting and analyzing the two-year test results from the Foundational Skills Assessment, a province-wide standardized test administered annually in British Columbia, Canada. Multilevel modeling was conducted to analyze whether the impact of COVID-19 correlated with local school district demographics, including the percentage of indigenous students, the percentage of students with special needs, and the median household income. The results revealed that the impact of COVID-19 on students' literacy and numeracy achievement was associated with the percentage of students with special needs and median household incomes in the local school districts. Implications of the findings for postpandemic revitalization were discussed.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42851"},"PeriodicalIF":3.4,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11891674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoparticles of natural product-derived medicines: Beyond the pandemic.","authors":"Yedi Herdiana","doi":"10.1016/j.heliyon.2025.e42739","DOIUrl":"10.1016/j.heliyon.2025.e42739","url":null,"abstract":"<p><p>This review explores the synergistic potential of natural products and nanotechnology for viral infections, highlighting key antiviral, immunomodulatory, and antioxidant properties to combat pandemics caused by highly infectious viruses. These pandemics often result in severe public health crises, particularly affecting vulnerable populations due to respiratory complications and increased mortality rates. A cytokine storm is initiated when an overload of pro-inflammatory cytokines and chemokines is released, leading to a systemic inflammatory response. Viral mutations and the limited availability of effective drugs, vaccines, and therapies contribute to the continuous transmission of the virus. The coronavirus disease-19 (COVID-19) pandemic has sparked renewed interest in natural product-derived antivirals. The efficacy of traditional medicines against pandemic viral infections is examined. Their antiviral, immunomodulatory, anti-inflammatory, and antioxidant properties are highlighted. This review discusses how nanotechnology enhances the efficacy of herbal medicines in combating viral infections.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42739"},"PeriodicalIF":3.4,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11904502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gradual strengthening of global oceanic surface winds: Correlations with sea surface temperature and implications for wind power extraction.","authors":"Wei-Bo Chen","doi":"10.1016/j.heliyon.2025.e42788","DOIUrl":"10.1016/j.heliyon.2025.e42788","url":null,"abstract":"<p><p>Understanding the long-term variabilities and trends of global oceanic surface wind speed is critical for extracting wind power. Therefore, 84 years (from 1940 to 2023) of global 10-m wind speed data derived from the fifth-generation ECMWF reanalysis, ERA5 (European Centre for Medium-Range Weather Forecasts Reanalysis v5), were utilised to analyse the long-term trends in the global 10-m wind speed. The results revealed that the wind speeds at the oceanic surface are much greater than those at the terrestrial surface, causing marine areas to be more suitable for extracting wind power. The global average 10-m oceanic wind (OW) speed increased by 0.074 % annually, while 0.065 % and 0.082 % were found for the Northern Hemisphere (NH) and Southern Hemisphere (SH), respectively. The region with the most critical trend of increasing 10-m OW speed is in the SH at S60°, with an average annual increase of approximately 0.02 ms^-1 during the winter (December, January, February, DJF). The global 84-year average sum of the wind power density (WPD) at a height of 100 m could reach 110.66 MWm^-1, in which the ocean basin within S40°-S60° accounts for 35.55 %. The SST and 10-m OW speed exhibit a causal relationship and positive correlation; however, this phenomenon can be observed only on a global spatial scale and a yearly temporal scale. The cross-correlations and Granger causality test between the sea surface temperature (SST) and 10-m OW speed indicated that the former can be used to predict the latter on a global scale. Analysing data from 1940 to 2023 showed that a 1 °C increase in the global annual average SST can enhance the global annual average 10-m OW speed by approximately 0.63 ms^-1.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42788"},"PeriodicalIF":3.4,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11889582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An integrated fuzzy logic approach for valuation of power transformer's degree of healthiness or faultiness.","authors":"J M Makacha, Edwell T Mharakurwa, L O Mogaka","doi":"10.1016/j.heliyon.2025.e42789","DOIUrl":"10.1016/j.heliyon.2025.e42789","url":null,"abstract":"<p><p>A substantial number of power transformers that are in use mainly in developing countries are aged and operating beyond their technical design life. This has forced many power utility entities to embrace condition-based maintenance strategies in an effort to prolong assets functionality and reduce equipment failures. To maximize the continuous use of aging power system assets, it is essential to comprehend the variables that pose a threat to the technical and operational lifetime. This paper proposes a model for estimating Degree of Healthiness (DOH) or Faultiness (DOF) of power transformers by synthesizing multiple measured variables, grouped into factors and calculating their corresponding scores. The numerical scores are translated to qualitative assessments through fuzzy logic inference system and thus DOH/DOF derived from the factors is evaluated to give an overall valuation of the in-service power transformer. Furthermore, a nonintrusive degree of polymerization (DP) model based on furans, carbon oxide ratios and methanol as DP pointers is also factored to map the paper insulation condition. Fuzzy rules formulation was centered on variable weighting values established through Analytical Hierarchical Process (AHP) approach. To diagnose the transformer incipient faults, a modified Duval pentagon methodology was employed in interpretation of the Dissolved Gas Analysis (DGA). The accuracy and effectiveness of the established Modified Combined Duval Pentagon (MCDP) technique is high as compared to those of the Pentagon 1 & 2 and combined pentagon methods using the six IEC faults. Results from DOH/DOF evaluation have indicated that DGAF and DPF are more impactful relative to the other factors. Timely knowledge of DOH/DOF of an in-service power transformer can have a great impact in asset managers' decision making on transformer maintenance and loading management.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42789"},"PeriodicalIF":3.4,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11889552/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanosilica-polyacrylic acid superabsorbent hydrogel derived from fast concentration gradient method for remediation of Congo red wastewater.","authors":"Kazem Mohammadzadeh, Mohsen Sayfi Klishomi, Saeed Alikhani, Mostafa Mahinroosta","doi":"10.1016/j.heliyon.2025.e42799","DOIUrl":"10.1016/j.heliyon.2025.e42799","url":null,"abstract":"<p><p>This study presents a novel composite superabsorbent hydrogel (SAH) synthesized from nanosilica and polyacrylic acid, demonstrating exceptional efficacy in removing Congo Red dye from wastewater. Utilizing a fast concentration gradient method, we achieved the synthesis of nanosilica with a high specific surface area of 380 m²/g, a total pore volume of 0.81 cm³/g, and a mean pore diameter of 17 nm. The modified nanosilica particles are well-dispersed, with around 83.5 % of the particles falling within the 20-35 nm size range. The resulting composite hydrogel exhibited a swelling ratio of 165 % after 135 min immersion in water. Remarkably, the hydrogel achieved over 98.5 % dye removal efficiency at a sorbent dosage of 3 g/L and a contact time of 1 h at pH 7. The maximum monolayer capacity obtained from the Langmuir isotherm was 555.56 mg/g. Additionally, it maintained a dye removal efficiency of 71.6 % after five regeneration cycles, highlighting its potential for sustainable wastewater treatment applications. The possible mechanisms for the removal of Congo Red dye involve electrostatic interactions and hydrogen bonding between the dye molecules and silica nanoparticles or hydrogel, facilitated by functional groups such as hydroxyl, carboxylic, and amino groups. This research not only advances the understanding of hydrogel properties but also introduces an innovative approach to enhance the performance of nanosilica-based adsorbents in environmental remediation, marking a significant contribution to the field of wastewater management.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42799"},"PeriodicalIF":3.4,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11891683/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}