Heliyon最新文献

{"title":"Evaluation of the phytochemical, bioactive compounds and descriptive sensory of encapsulated lingzhi (<i>Ganoderma lucidum</i>) extracts with combined wall materials for masking effect on the perception of off-flavour and bitterness.","authors":"Threethip Chuensun, Teera Chewonarin, Witida Laopajon, Rajnibhas Sukeaw Samakradhamrongthai, Worrapob Chaisan, Niramon Utama-Ang","doi":"10.1016/j.heliyon.2024.e40094","DOIUrl":"10.1016/j.heliyon.2024.e40094","url":null,"abstract":"<p><p>Lingzhi mushroom (<i>Ganoderma lucidum</i>) is known as a medicinal mushroom that can be utilized in various functional foods available in the market, including powders, dietary supplements, and tea. However, its use is limited due to factors such as bitterness, flavour, and astringency. The objective of this study is to characterize and quantify the sensory profile of Lingzhi mushroom samples (fresh, dried and Lingzhi extracts) using quantitative descriptive analysis and investigate the physicochemical and sensory properties of encapsulated Lingzhi extracts using different ratios of wall material (maltodextrin, gum Arabic and modified starch from rice flour). The optimal ratio for encapsulation involved 32.75 % maltodextrin, 42.25 % gum Arabic, and 25 % modified starch w/w. Three parallel experiments were performed under practical conditions, resulting in average encapsulation efficiencies of 88.39 ± 0.09 % for flavonoids 89.53 ± 0.06 % for polysaccharides and 0.31 ± 0.01 of water activity. The sensory descriptive analysis indicated the following ratings: brown sugar aroma (4.36 ± 0.17), earthy aroma (22.04 ± 0.12), nutty aroma (2.00 ± 0.01), fresh mushroom aroma (11.18 ± 0.19), dried Lingzhi aroma (3.08 ± 0.13), black tea aroma (4.50 ± 0.19), salty taste (1.00 ± 0.01), earthy flavour (23.14 ± 0.22) and Mushroomy (after taste) (2.06 ± 0.09), respectively. The flavour identified of Lingzhi extracts and encapsulated by gas chromatography electronic nose (GC-E-Nose). The result showed ten flavour compounds (Acetaldehyde, Methanethiol, Propanal, propane-2-one, Methyl acetate, 2-methyl propanal, Ethyl Acetate, Heptane, 1-Butanamine, 2-methyl butanal, Thiophene). Optimizing the encapsulation conditions has a significant impact on reducing off-flavours and bitterness. Comparing the flavour profiles of Lingzhi extracts with encapsulated Lingzhi extracts using gas chromatography electronic nose (GC-E-Nose). Encapsulation technology represents a burgeoning field that holds immense potential in ensuring the stability of functional ingredients and facilitating their incorporation into instant beverage products.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"10 21","pages":"e40094"},"PeriodicalIF":3.4,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11570458/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated effects of furrow irrigation systems and irrigation regimes on water productivity of onion (Allium <i>cepa</i> L.) crop in a semi-arid area.","authors":"Getachew Wandifra Boru, Tigabie Setu Birhan, Terhas Legese Beyene","doi":"10.1016/j.heliyon.2024.e40098","DOIUrl":"10.1016/j.heliyon.2024.e40098","url":null,"abstract":"<p><p>Dwindling water resources with inept field water management impends sustainable agricultural production in semi-arid areas of Ethiopia. Thus, the adaption and adoption of improved irrigation water running lines are indispensable and imperative to recuperate water productivity in areas where water resources are inadequate. The ground experiments were pointed to elucidate the weight of conventional, alternate, and fixed furrow irrigation systems under irrigation levels of 100 %, 70 %, and 40 % of crop evapotranspiration (ETc) on onion growth, yield, water productivity, and economic return in Alage, Central, Ethiopia. The field trials were conducted at nine treatments arranged in a randomized complete block design with three replications and water was managed at fixed intervals with variable depth approach. The result illustrated that furrow systems in conjunction with irrigation levels had a weighty pertain (P < 0.05) on onion growth, yield, water productivity, and economic return. The highest yield of 30.75 ton ha^-1 was achieved at conventional furrow irrigation with 100%ETc dictated to zero water saving subsequently, the crop and irrigation water productivity dropped with the values of 6.86 and 5.61 kg m^-3 respectively. The diminished yield of 6.39 ton ha^-1 obtained at fixed furrow irrigation with 40%ETc conquered the saved water output lastly, the crop and irrigation water productivities demoted with values of 6.87 and 5.70 kg m^-3 respectively. Nevertheless, 24.93ton ha^-1 of ideal yield was obtained under alternative furrow irrigation with 100%ETc and the 50 % hoarded water was higher than the yield decline. Consequently, the crop and irrigation water productivities rose with values of 10.96 and 9.09 kg m^-3 respectively. Eventually, the saved water opened for 0.03ha extra irrigable area that will onward to the highest total expected yield of 37.40 ton ha^-1 as compared with all other treatments. Under conventional furrow irrigation with 100%ETc, the obtained yield dominated the wastewater accordingly, the highest net return of 668484ETB ha^-1 and benefit-cost ratio of 3.63 was achieved. Besides, the unbearable yield penalty under fixed furrow with 40 % headed to negative net return and lowest befit cost ratio as related with other treatments. However, further economic results confirmed that the 50 % saved water under alternative furrow with 100 % can recompense for the net return reduction that will make this trial combination preferable as compared with other treatments. Other results also recommended that, under water-limiting and inefficient field water governing conditions, alternative furrow irrigation with 100%ETc can be the ideal blend to enhance water productivity in semi-arid regions of Ethiopia and elsewhere that share similar agroclimatic conditions.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"10 21","pages":"e40098"},"PeriodicalIF":3.4,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11570297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of different transfer strategies for in vitro fertilization/intracytoplasmic sperm injection with poor-quality embryos-Analysis of embryonic development, perinatal period, and neonatal outcomes.","authors":"Lei Jin, Zhou Li, Keyi Si, Bingxin Ma, Xinling Ren, Bo Huang","doi":"10.1016/j.heliyon.2024.e40103","DOIUrl":"10.1016/j.heliyon.2024.e40103","url":null,"abstract":"<p><p>During the in vitro fertilization and embryo transfer process, some expectant mothers may not have good embryos to choose from before the embryo transfer. Recommendations for this condition are currently unclear, and relevant clinical and neonatal outcomes are still lacking. This study analyzed the outcomes of poor-quality embryo transfers, including fetal outcomes, in the fresh cycle and frozen-thawed embryo transfer cycle. Embryos were also analyzed for abnormalities during the cleavage stage. The results indicate that in the absence of good embryos, clinicians and embryologists could advise expectant mothers to continue culturing the embryos to the blastocyst stage and undergo transfer if blastocysts are formed. This finding can also be used as a reference for many expectant mothers with frozen embryos that have not yet been thawed.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"10 21","pages":"e40103"},"PeriodicalIF":3.4,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11570467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human exposure to chromite mining pollution, the toxicity mechanism and health impact.","authors":"Changaiz Khan, Riffat Naseem Malik, Jing Chen","doi":"10.1016/j.heliyon.2024.e40083","DOIUrl":"10.1016/j.heliyon.2024.e40083","url":null,"abstract":"<p><p>Significant amounts of toxic metal-containing mining waste are produced by chromium mining activities, along with the production of air pollutants. The presence of toxic metals in various environmental media including air, water, and soil, along with their chemical species such as hexavalent chromium, pose major health hazards for both directly exposed mining workers and the population residing near the mining areas. Highlighting the requirements for enhanced environmental protection and safety measures, this comprehensive review shed light on the global environmental pollution stemming from chromite mining activities. Based on the published literature, the study also investigated into the pollution caused by toxic metals and explored their probable health effects on exposed individuals. The exposure routes and the mechanisms of toxic metal induced carcinogenicity in the exposed groups were assessed. Additionally, the generated reactive species in exposed individuals and the toxicity mechanisms of hexavalent chromium were discussed. Considering these findings, this review proposed the necessity of cross-sectional biomonitoring studies involving occupationally exposed workers from chromite mining operations. The anticipated impact of this review is to influence the global and national chromite mining industry, instigating improvements in occupational settings, real-time pollution monitoring, and healthcare provisions for exposed workers.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"10 21","pages":"e40083"},"PeriodicalIF":3.4,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11566874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relative fitness of wild-type and phage-resistant pyomelanogenic <i>P. aeruginosa</i> and effects of combinatorial therapy on resistant formation.","authors":"Aarcha Shanmugha Mary, Nashath Kalangadan, John Prakash, Srivignesh Sundaresan, Sutharsan Govindarajan, Kaushik Rajaram","doi":"10.1016/j.heliyon.2024.e40076","DOIUrl":"10.1016/j.heliyon.2024.e40076","url":null,"abstract":"<p><p>Bacteriophages, the natural predators of bacteria, are incredibly potent candidates to counteract antimicrobial resistance (AMR). However, the rapid development of phage-resistant mutants challenges the potential of phage therapy. Understanding the mechanisms of bacterial adaptations to phage predation is crucial for phage-based prognostic applications. Phage cocktails and combinatorial therapy, using optimized dosage patterns of antibiotics, can negate the development of phage-resistant mutations and prolong therapeutic efficacy. In this study, we describe the characterization of a novel bacteriophage and the physiology of phage-resistant mutant developed during infection. M12PA is a <i>P. aeruginosa</i>-infecting bacteriophage with Myoviridae morphology. We observed that prolonged exposure of <i>P. aeruginosa</i> to M12PA resulted in the selection of phage-resistant mutants. Among the resistant mutants, pyomelanin-producing mutants, named PA-M, were developed at a frequency of 1 in 16. Compared to the wild-type, we show that PA-M mutant is severely defective in virulence properties, with altered motility, biofilm formation, growth rate, and antibiotic resistance profile. The PA-M mutant exhibited reduced pathogenesis in an allantoic-infected chick embryo model system compared to the wild-type. Finally, we provide evidence that combinatory therapy, combining M12PA with antibiotics or other phages, significantly delayed the emergence of resistant mutants. In conclusion, our study highlights the potential of combinatory phage therapy to delay the development of phage-resistant mutants and enhance the efficacy of phage-based treatments against <i>P. aeruginosa</i>.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"10 21","pages":"e40076"},"PeriodicalIF":3.4,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11570307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geochemistry of Totogan Formation as potential source rock and its relationship with oil seepage manifestations in the Banjarnegara areas, Central Java, Indonesia.","authors":"Praptisih, Yoga Andriana Sendjaja, Vijaya Isnaniawardhani, Anggoro Tri Mursito, Taufik Ramli, Muhammad Maruf Mukti, Rakhmat Fakhruddin","doi":"10.1016/j.heliyon.2024.e40010","DOIUrl":"10.1016/j.heliyon.2024.e40010","url":null,"abstract":"<p><p>The Central Java area, especially the North Serayu Basin, has the potential to accumulate hydrocarbons, as evidenced by the many manifestations of oil and gas seepage on the surface. This research in the Banjarnegara area, part of the North Serayu Basin, aims to determine the geochemistry characteristics of potential source rock of the Totogan Formation and existing oil seepage, as well as their genetic relation. Fifteen surface rock samples were analysed for the total organic carbon (TOC) content and Rock-Eval pyrolysis. Then, several samples were selected to examine the biomarker composition using GC. and GC-MS analysis. Meanwhile, the biomarker data of oil seepage data was obtained from previously published data. The identified terpanes and steranes biomarkers of potential source rock and oil seepage samples were performed to determine the relationship of oil seepage to its potential source rock. The research reveals that the Totogan Formation was deposited under suboxic to oxic conditions that can be distinguished into the estuary or bay deposit composed mainly of higher plant organic matter and the open marine deposit with input mainly from algae organic matter. Another important finding is a positive oil-to-source rock correlation between existing oil seepage and the Totogan Formation based on biomarker data. Thus, the findings of this research suggest that the Totogan Formation is the source rock of the existing oil seepage in this research area.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"10 21","pages":"e40010"},"PeriodicalIF":3.4,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11570459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bibliometric analysis of scholarly publications related to family medicine in Thailand.","authors":"Nutchar Wiwatkunupakarn, Sasiwimon Moonkayaow, Abigail Morse, Nida Buawangpong, Suphawita Pliannuom, Soe Sandi Tint, Apichai Wattanapisit, Chaisiri Angkurawaranon","doi":"10.1016/j.heliyon.2024.e40090","DOIUrl":"10.1016/j.heliyon.2024.e40090","url":null,"abstract":"<p><strong>Background: </strong>Family medicine has been recognized as a medical specialty in Thailand. However, there is a lack of information about scholarly publications. Bibliometric analysis is a valuable methodology for identifying research trends and knowledge gaps in this field. This study aims to analyze scholarly publications related to family medicine in Thailand.</p><p><strong>Method: </strong>This bibliometric analysis was conducted based on the PubMed search in March 2023. All relevant literature related to 'family medicine' and 'Thailand' was retrieved. Performance analysis examined the publication trends from 1963 to 2023, the top 10 journals publishing relevant articles, and the number of publications by research areas. Science mapping depicted clusters of co-occurring author keywords, their relationships, and the research themes' trend over two decades.</p><p><strong>Results: </strong>A total of 1483 publications were retrieved. The number of publications showed an upward trend, increasing from 61 before 2000 to 359 in 2020. The Journal of the Medical Association of Thailand was the leading journal, publishing 267 articles (18.0 %). Research areas were categorized into Basic Knowledge (n = 211), Clinical Problem Solving (n = 714), Health Service (n = 256), Health System (n = 254), and Medical Education (n = 48). Science mapping identified six clusters based on 106 co-occurrence keywords, including public health, health services, medical issues in older adults, healthcare access, epidemiology, and others. Research themes have shifted from infectious diseases and public health to primary care and non-communicable diseases.</p><p><strong>Conclusion: </strong>Future research should focus more on implementation at a population level and healthcare system, with more investigation into geriatric care and child and maternal health.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"10 21","pages":"e40090"},"PeriodicalIF":3.4,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11570295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Botanical origins of honeys from pollen analysis during the main honey flow across agro-ecologies in kelala district, South Wollo, Ethiopia.","authors":"Oumer Hussein, Ali Seid","doi":"10.1016/j.heliyon.2024.e40101","DOIUrl":"10.1016/j.heliyon.2024.e40101","url":null,"abstract":"<p><p>This study aimed to identify the botanical origins of honey through pollen analysis across agro-ecologies of Kelala district, South Wollo, Ethiopia. Fifteen honey samples were collected from traditional beehives, with 5 samples from each of the highland, midland, and lowland agro-ecologies. Qualitative and quantitative pollen analyses revealed that 22 honeybee plants belonging to 8 families, with no families of poisonous origin, and 3 growth forms were identified. Among these plant species, 18 were found in the midland and 13 were recorded in each of the highland and lowland agro-ecologies. The family Fabaceae, with 7 (31.81 %) of the identified honeybee plants, was highly dominant (p < 0.03) compared to the other families. Herbs, with 18 plant species, were highly dominant (p < 0.001) compared to shrubs and trees. In terms of plant species diversity, 10 plant species (<i>Bidens pachyloma, Guizotia scabra, Becium grandiflorum, Eleusine floccifolia, Lens culinaris, Lippia adoensis, Medicago polymorpha, Ocimum basilicum, Trifolium steudneri,</i> and <i>Zea mays</i>) were found in more than 50 % of the honey samples, with the first 2 in all the samples studied. Analysis of each honey sample showed that 8 (53.33 %) of the samples were monofloral, 3 (20 %) were bifloral, and the rest were multifloral. However, all the honeys produced due to agro-ecology (geographical origin) were monofloral. <i>Guizotia scabra</i> in the highland and <i>Bidens pachyloma</i> in the midland and lowland agro-ecologies were the predominant pollen producing species and contributors of monofloral honey. In conclusion, the safe and healthy monofloral honey produced across agro-ecologies suggests the suitability of the honey for human consumption and can potentially attract investors.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"10 21","pages":"e40101"},"PeriodicalIF":3.4,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11565392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibacterial and antibiofilm features of <i>mut</i>SMAP-18 against <i>Vibrio cholerae</i>.","authors":"Ishrat Jahan, Byambasuren Ganbaatar, Chul Won Lee, Sung-Heui Shin, Sungtae Yang","doi":"10.1016/j.heliyon.2024.e40108","DOIUrl":"10.1016/j.heliyon.2024.e40108","url":null,"abstract":"<p><p>Cholera continues to be a pointed global health issue, prominently in developing nations, where the disease's severe diarrheal symptoms pose substantial public health risks. With the escalating spread of antibiotic resistance among <i>V. cholerae</i> strains, alternative therapeutic approaches are imperative. Antimicrobial peptides are increasingly recognized for their potential, with research focusing on finding the most effective options. We explored the antibacterial and antibiofilm properties of analogues of sheep myeloid antimicrobial peptide-18 (SMAP-18) against <i>V. cholerae</i> in this investigation. Our prior research demonstrated that substituting glycine with alanine at different positions within SMAP-18 altered its structure and antimicrobial activity. Among these altered analogues, our focus was on a mutant variant (<i>mut</i>SMAP-18), characterized by glycine-to-alanine substitutions at positions 2, 7, and 13. Our results indicated that <i>mut</i>SMAP-18 exhibited heightened antimicrobial and antibiofilm activities against <i>V. cholerae</i> compared to SMAP-18. We conducted several mechanistic investigations to check the membrane integrity using DNA-binding dye, SYTOX Green or measuring calcein dye leakage and analyzing flow cytometry by fluorescence-activated cell sorting (FACScan). From these tests, we elucidated that SMAP-18 primarily functions intracellularly, while <i>mut</i>SMAP-18 targets the bacterial membrane. Additionally, scanning electron microscopy (SEM) images illustrated membrane disruption at lower concentrations for <i>mut</i>SMAP-18. Notably, <i>mut</i>SMAP-18 demonstrated significant antibiofilm properties against <i>V. cholerae</i>. Overall, these findings offer valuable perspectives for developing novel antibacterial therapies targeting the pathogenic <i>V. cholerae</i>.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"10 21","pages":"e40108"},"PeriodicalIF":3.4,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11570489/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-coding RNAs in oral cancer: Emerging biomarkers and therapeutic frontier.","authors":"Mehrdad Hashemi, Saloomeh Khoushab, Mina Hobabi Aghmiuni, Saeid Nemati Anaraki, Mina Alimohammadi, Afshin Taheriazam, Najma Farahani, Maliheh Entezari","doi":"10.1016/j.heliyon.2024.e40096","DOIUrl":"https://doi.org/10.1016/j.heliyon.2024.e40096","url":null,"abstract":"<p><p>Around the world, oral cancer (OC) is a major public health problem, resulting in a significant number of deaths each year. Early detection and treatment are crucial for improving patient outcomes. Recent progress in DNA sequencing and transcriptome profiling has revealed extensive non-coding RNAs (ncRNAs) transcription, underscoring their regulatory importance. NcRNAs influence genomic transcription and translation and molecular signaling pathways, making them valuable for various clinical applications. Combining spatial transcriptomics (ST) and spatial metabolomics (SM) with single-cell RNA sequencing provides deeper insights into tumor microenvironments, enhancing diagnostic and therapeutic precision for OC. Additionally, the exploration of salivary biomarkers offers a non-invasive diagnostic avenue. This article explores the potential of ncRNAs as diagnostic and therapeutic tools for OC.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"10 21","pages":"e40096"},"PeriodicalIF":3.4,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11582460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}