Heliyon最新文献

{"title":"Fecal microbiota transplantation in a patient hospitalized in the intensive care unit - Case report.","authors":"Katarzyna Oliwa-Libumska, Aleksandra Jaworska-Czerwinska, Malgorzata Mallek-Grabowska, Robert Wlodarski, Przemyslaw Zuratynski, Bartosz Kozlowski","doi":"10.1016/j.heliyon.2025.e42793","DOIUrl":"10.1016/j.heliyon.2025.e42793","url":null,"abstract":"<p><p>Clostridioides difficile infections are difficult and serious problem occurring in patients staying in intensive care units. In recent years, the number and severity of these infections, as well as the mortality rate, have been increasing, posing a serious epidemiological problem. This is caused, among other factors, by stressors, artificial nutrition, and sepsis, which lead to disturbances in the patients' microbiome. Basic method of treatment is antibiotic therapy, however some patients experience recurrences of the infection. Fecal Microbiota Transplantation (FMT) is one of the alternative methods used in treating recurring infections of Clostridioides difficile etiology (Clostridioides Difficile Infection, CDI). The presented case refers to a patient with severe pseudomembranous enterocolitis who underwent FMT twice. This report highlights the role of FMT in the treatment of severe Clostridioides difficile infections in critically ill patients.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42793"},"PeriodicalIF":3.4,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of photoinduction in PANi/TiO₂ heterogeneous structure on conductance of PANi component.","authors":"Huyen Ngoc Duong, Tan Van Le","doi":"10.1016/j.heliyon.2025.e42807","DOIUrl":"10.1016/j.heliyon.2025.e42807","url":null,"abstract":"<p><p>A heterostructure consisting of a PANi and a TiO₂ layer was chemically deposited consecutively on a glass substrate to investigate the effect of photoinduction in the structure on the conductance of the PANi component. It has been found that in response to the excitation light, the conductance of the PANi component in the PANi/TiO₂ heterostructure exhibits a distinct mode to be different from that of a single pristine PANi layer. The features account for the effects of photoelectronic and electrochemical processes that associate with the photoinduction in the PANi/TiO₂ heterostructure. The photoelectronic effect involves the appearance of the excess charges photogenerated inside the heterostructure on the depletion region. Due to the thermal diffusion of excess charges across the heterojunction, the width of the depletion is altered, leading to a modification in the conductance of the structure components, including the PANi. The electrochemical effect, on the other hand, relates to the appearance of the reactive oxygen species of O₂ ^•-, OH^•- and H⁺ that are created outside the heterostructure surface due to the photoinduction. Acting as strong oxidants, the species play the role of extra acceptor-like dopants and donor dedoping agents that modify the oxidation state and then the hole density of the p-type semiconductor PANi. The initial modification causes a sudden drop in PANi conductance at the start. As the exposure is further prolonged, the oxidation degree of the PANi component is further altered; the initial PANi emeraldine salt is gradually inverted to the emeraldine base, resulting in a conversion of its conductance. The combination of two modifications is explained for the mixing responses in the conductance of the PANi component and the U-turn shape of its baseline.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42807"},"PeriodicalIF":3.4,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903889/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance enhancement of a shell-and-coil ice storage enclosure for air conditioning using spiral longitudinal fins: A numerical approach.","authors":"Masoud Izadi, Farhad Afsharpanah, Ali Mohadjer, Mostafa Omran Shobi, Seyed Soheil Mousavi Ajarostaghi, Federico Minelli","doi":"10.1016/j.heliyon.2025.e42786","DOIUrl":"10.1016/j.heliyon.2025.e42786","url":null,"abstract":"<p><p>This study carries out a series of complex unsteady three-dimensional (3D) computational analyses that were validated by experimental tests to examine the performance enhancement of a cylindrical shell-and-coil ice storage enclosure by employing various spiral longitudinal fin geometries covering the heat transfer fluid (HTF) tubes throughout the transient process of solid-liquid phase change. The phase change material (PCM) in this work was selected to be water and the tubes and fins were chosen to be made of copper alloy. To study how this type of fin accelerates the charging process, several dimensionless parameters related to the spiral longitudinal fin geometries were defined, which included dimensionless fin length (<i>Ω</i>), count (<i>Ψ</i>), and thickness (<i>Φ</i>) parameters. Additionally, the impact of fin orientation was evaluated. The findings suggested that raising <i>Ω</i> from 0 to 0.719 reduces the solidification time by 42.29 %. Similarly, changing the <i>Ψ</i> from 0 to 6 expedites the process by 50 %. Regarding the changes of <i>Φ</i>, it was observed that even though the freezing dynamic was not sensitive to this parameter in the first half of the process, the effect was more pronounced throughout the second half. Furthermore, with identical heat transfer areas, horizontal fins outperformed the vertical ones by a marginal difference of 3.58 %, which was found to be because of the better distribution of fins within the container.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42786"},"PeriodicalIF":3.4,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11891728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The application of multiple linear regression methods to FTIR spectra of fingernails for predicting gender and age of human subjects.","authors":"L Mihaly Cozmuta","doi":"10.1016/j.heliyon.2025.e42815","DOIUrl":"10.1016/j.heliyon.2025.e42815","url":null,"abstract":"<p><p>The paper explores the accuracy of gender and age prediction of human subjects based on the chemometric analysis of FTIR spectra from fingernails. The baseline and scaling over the 0-1 range were applied to FTIR spectra from fingernails of 123 subjects, and wavenumbers for which absorbance values showed a statistically significant correlation with gender and age were identified. The prediction accuracy was analyzed using: Multiple linear regression, Forward stepwise regression, Backward stepwise regression, Principal component regression, and Partial least squares regression. As regard the gender prediction, the principal component regression model proved to be the most accurate, with 8 extracted components allowing a prediction of 93.50 % (86.00 % for women, 98.63 % for men). The predictive power of the model showed that in case of new subjects, gender classification could be done in 91.06 % of cases (84.00 % for women, 95.89 % for men). For age prediction, the optimal backward stepwise regression model with 6 statistically significant predictors showed an average error of 11.39 % (13.70 % for women, 9.81 % for men). The predictive power of the model was 12.13 % (11.73 % for women, 10.35 % for men). The age prediction was less accurate, with a maximum error of 10.00 % achieved only in the case of 65.04 % of subjects.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42815"},"PeriodicalIF":3.4,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11891726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health risk assessments of heavy metals in dust samples collected from classrooms in Ilorin, Nigeria and its impact on public health.","authors":"Hussein K Okoro, Muyiwa M Orosun, Afisat F Agboola, Ebuka Chizitere Emenike, Sireesha Nanduri, Navin Kedia, Muthena Kariem, Ati Priya, Safia Obaidur Rab","doi":"10.1016/j.heliyon.2025.e42769","DOIUrl":"10.1016/j.heliyon.2025.e42769","url":null,"abstract":"<p><p>Over the past three decades, heavy metals (HMs) in indoor dust have been a significant focus due to their environmental and health risks. This study assessed HM contamination (Co, Pb, Cd, Cr, Ni, and As) in classroom and lecture theatre dust in Ilorin, Nigeria, across dry and rainy seasons. Dust samples from primary, secondary, and university settings were analyzed using atomic absorption spectrometry and ICP-OES. HM concentrations followed the order As > Pb > Co > Cr > Ni > Cd, all below background values. Indices like geoaccumulation (Igeo), contamination factor (CF), and pollution load index (PLI) indicated minimal contamination. The proportion of human health risks attributed to dermal contact, represented by HQderm and CRderm, accounted for 67.76 % and 30.30 % of the total hazard index (HI) and cancer risk (CR) during the dry season, and 86.76 % and 72.65 % during the rainy season, respectively. Health risks via ingestion, inhalation, and dermal exposure showed children were more vulnerable than adults, with dermal pathways contributing significantly to overall risk. Principal component and geo-spatial analyses highlighted natural and anthropogenic HM sources. The findings provide critical data for policymakers to develop effective strategies for minimizing HM exposure in indoor environments.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42769"},"PeriodicalIF":3.4,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11894315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the adoption of multiple Integrated Striga Management (ISM) technologies among smallholder maize farmers in rural Northern Nigeria.","authors":"Lloyd J S Baiyegunhi, Mohammad B Hassan","doi":"10.1016/j.heliyon.2025.e42774","DOIUrl":"10.1016/j.heliyon.2025.e42774","url":null,"abstract":"<p><p>The adoption of Integrated Striga Management (ISM) technology has been recommended as an effective approach to mitigating Striga infestation, a significant challenge to maize productivity and food security. Despite substantial efforts by stakeholders to promote its deployment, adoption levels remain low. This study utilized data from 643 smallholder farmers sampled across Bauchi and Kano states in Northern Nigeria. A multivariate probit (MVP) model and a zero-truncated Poisson model were employed to examine simultaneous interdependent adoption decisions of ISM technology and adoption intensity among maize farmers. The findings reveal interdependencies among ISM technology components, with some acting as substitutes while others function as complements. The analysis also highlights that household socio-economic characteristics, farm-level features, psychological traits, and institutional factors significantly influence both ISM technology adoption and the intensity of its use. The study discusses policy implications, emphasizing the need to target these identified factors to enhance the adoption and intensification of ISM technology components in the study area.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42774"},"PeriodicalIF":3.4,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11891666/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caregiver-perpetrated violence against patients with severe mental disorders and associated factors in Bahir Dar, northwest Ethiopia.","authors":"Mastewal Aschale Wale, Fikir Addisu, Habte Belete, Wubalem Fekadu, Agmas Wassie, Aklile Tsega Chekol","doi":"10.1016/j.heliyon.2025.e42861","DOIUrl":"10.1016/j.heliyon.2025.e42861","url":null,"abstract":"<p><strong>Background: </strong>Caregiver abuse has widespread negative effects on patients with serious mental illnesses in terms of ethics, law, society, culture, and economy. However, studies in low-income nations, such as Ethiopia, are scarce. Consequently, the purpose of this study was to evaluate the prevalence of caregiver aggression and related variables in patients with severe mental illnesses.</p><p><strong>Methods: </strong>An institutional-based cross-sectional study was conducted among 394 people with severe mental disorders who were selected through a systematic random sampling technique. Data were gathered through in-person interviews using Epicollect-5 software on a smartphone. The data were then exported into the Statistical Package for Social Science for analysis. A p-value of less than 0.25 in the bivariate analysis indicated a potential candidate for additional multiple logistic regression analysis to control the possible confounders. A p-value of less than 0.05 was used to establish statistical significance in multivariate logistic regression analysis.</p><p><strong>Results: </strong>The study's participant response rate was 98 %. There was 36.3 % (95 % CI = 31.5 %, 41.3 %) caregiver violence. Of these, 49.7 % (71/143) of them reported having experienced abuse from caregivers in the previous year. A significant number of factors were associated with the outcome variable including, average monthly income of less than 2000 Ethiopian Birr (AOR = 3.31; 95 % CI 1.33, 8.24), co-morbid illness (AOR = 3.45; 95 % CI 1.51, 7.98), number of episodes (AOR = 3.29; 95 % CI 3.59, 11.02), length of illness (AOR = 4.17; 95 % CI 2.19, 7.91), and having a history of aggression in the past (AOR = 4.80; 95 % CI 3.48, 7.90).</p><p><strong>Conclusion: </strong>More than a third (36.3 %) of individuals with serious mental illnesses experienced caregiver violence. The following factors were found to be predictive of carer violence: income, co-morbid illness, number of episodes, and history of aggression. This indicates there is a need for public health attention among patients with severe mental disorders to prevent the violation of their human rights.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42861"},"PeriodicalIF":3.4,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11904567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response of intensive and thermophysical properties of a Pulsatile blood through Stenosed artery subject to drug delivery.","authors":"Anthuvan Ezhilarasi P, Dhivya Mohanavel","doi":"10.1016/j.heliyon.2025.e42748","DOIUrl":"10.1016/j.heliyon.2025.e42748","url":null,"abstract":"<p><p>A numerical attempt has been initiated to analyze an unsteady pulsatile blood flow of ternary nanoparticles (<i>Au</i>, <i>GO</i>, and <math><mi>F</mi> <msub><mrow><mi>e</mi></mrow> <mrow><mn>3</mn></mrow> </msub> <msub><mrow><mi>O</mi></mrow> <mrow><mn>4</mn></mrow> </msub> </math> ) in a two-dimensional model through tapered arterial stenosis when a magnetic field is present. The most significant motivations for treating tri-hybrid nanoparticles as nanomaterials is their exceptional antimicrobial and biocompatible properties, which enhance thermal conductivity and facilitate nano-drug delivery. The semi-analytical approach used in this model involves solving the governing Navier-Stokes equations. At the same time, computational simulations are performed using the shooting method with the assistance of a MATLAB solver. Furthermore, the effects of flow-related parameters such as wall shear stress and resistive impedance on velocity distribution have been discussed. The findings indicate that the wall shear stress rises with increasing Womersley parameters, whereas the flow velocity diminishes with higher magnetic parameter values. Moreover, sensitivity analysis is elucidated to ascertain the interrelated impacts of the key parameters. In addition, the current study also validated the existing results and it was found to have a good agreement. Major exploration of this study reveals that the obtained results may have implications for cancer treatment, tumor therapy, heart surgery, and other hyperthermia therapies.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42748"},"PeriodicalIF":3.4,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11891670/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of the profitability of poultry farming in the Gazipur district of Bangladesh.","authors":"G M Monirul Alam, Mst Tania Parvin, Md Ruhul Amin, Jarin Saiyara Promee","doi":"10.1016/j.heliyon.2025.e42773","DOIUrl":"10.1016/j.heliyon.2025.e42773","url":null,"abstract":"<p><p>Nowadays, smallholder poultry producers in Bangladesh face substantial challenges in operating their businesses profitably. This study looked at the factors that influence the profitability of poultry farming in Bangladesh's Gazipur area, employing primary data collected from 200 poultry farmers with 100 broiler and 100-layer producers. Econometric models were used to analyze the survey data. The findings demonstrate that the economic viability of poultry farming in the study areas was subject to various socioeconomic factors. The estimated parameters that significantly and positively influenced the profitability were the cost of hired labor and veterinary services with the coefficient value of 0.16 and 1.35, respectively. Conversely, the profitability exhibited an inverse relationship with education level, family size, costs of tools and equipment, and day-old chicks, with parameter estimates of 0.85, 1.73, 1.07, and 1.47, respectively. As the cost components in this study are found to have a dubious effect on profitability, specific cost-reduction strategies are required at both national and local levels to assist farmers in adhering to their budgetary constraints and enhancing their net farm profit. In addition, innovation in the poultry sector should be made readily available at an affordable cost, and factors that impede profitability, such as large family size and higher education, should be converted to assets through adequate training.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42773"},"PeriodicalIF":3.4,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11904478/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pyrolysis kinetics, mechanism and thermodynamics of peanut shell based on Gaussian function deconvolution.","authors":"Jialiu Lei, Liu Yang, Yuhao Wang, Dongnan Zhao","doi":"10.1016/j.heliyon.2025.e42800","DOIUrl":"10.1016/j.heliyon.2025.e42800","url":null,"abstract":"<p><p>As a typical biomass resource, peanut shell has the potential to produce energy and value-added products, as it is generated abundantly worldwide. Pyrolysis is increasingly utilized for the disposal of biomass wastes through thermal conversion into chemical raw materials. Assessing the pyrolysis kinetics, reaction mechanism, thermodynamic parameters for individual components of peanut shells is crucial for its valorization. In this study, conditions for pyrolysis were optimized under pure N₂ flow across temperatures ranging from 303 K to 1173 K at the temperature ramp of 10 K/min, 20 K/min, and 30 K/min. The peak-differentiating analysis using Gaussian function was employed to segregate the pyrolysis of peanut shell into several independent one-step parallel reactions, corresponding to pseudo-lignin, pseudo-cellulose, and pseudo-hemicellulose decomposition. The Coats-Redfern, Kissinger-Akahira-Sunose, Flynn-Wall-Ozawa, and Vyazovkin techniques were employed to estimate kinetic parameters and reaction mechanism for each pseudo-component of peanut shell. The performed analyses revealed that the average activation energy values generally followed an order of pseudo-lignin > pseudo-hemicellulose > pseudo-cellulose, with values of 174.31 kJ/mol, 133.89 kJ/mol, and 115.44 kJ/mol by Kissinger-Akahira-Sunose, 177.79 kJ/mol, 136.53 kJ/mol, and 120.33 kJ/mol by Flynn-Wall-Ozawa, and 174.96 kJ/mol, 134.29 kJ/mol, and 116.61 kJ/mol by Vyazoykin, respectively. The Coats-Redfern method indicated that the suitable mechanism of reaction for pseudo-hemicellulose and pseudo-cellulose were random nucleation-based, while diffusional-based mechanism was identified for pseudo-lignin. The thermodynamic analysis revealed that the decomposition of peanut shell was endothermic and non-spontaneous, and it can be converted into value-added sources of energy steadily through pyrolysis process. This study offers a reliable approximation of experimental data irrespective of pyrolysis behavior and guides the resourceful utilization of peanut shell.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42800"},"PeriodicalIF":3.4,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11904487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}