Heliyon最新文献

{"title":"Targeted-release budesonide: A comprehensive review on its potential in IgA nephropathy.","authors":"Fei-Fan Qi, Hui-Qin Zeng, Jian-Jiang Zhang","doi":"10.1016/j.heliyon.2025.e42729","DOIUrl":"10.1016/j.heliyon.2025.e42729","url":null,"abstract":"<p><p>IgA nephropathy (IgAN) is characterized by the presence of IgA deposits in the glomerular mesangium, representing a prevalent form of primary glomerulonephritis worldwide. This condition is associated with a significant risk of progression to end-stage renal disease (ESRD). Hypertension, proteinuria, and reduced glomerular filtration rate (GFR) are established risk factors. Although angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are currently the first-line treatments, they do not adequately mitigate the risk of disease progression. Budesonide is a potent corticosteroid that has been utilized for many years in the treatment of inflammatory diseases. Recently, a novel formulation, targeted-release budesonide (TRF-budesonide), was developed to facilitate drug release specifically in the distal ileum to treat IgAN. This review synthesizes the existing evidence on the impact of TRF-budesonide in IgAN, covering its pathogenesis, efficacy, and safety. It also explores comparisons between TRF-budesonide and other therapeutic options, highlighting the advantages of TRF-budesonide in reducing proteinuria and preserving renal function. While TRF-budesonide has demonstrated promising efficacy and safety in short- and medium-term studies, showcasing its potential as a valuable treatment option for IgAN, further high-quality randomized controlled trials are needed to comprehensively evaluate its long-term efficacy and safety. Such research will pave the way for more personalized and precise treatment options for patients with IgAN.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42729"},"PeriodicalIF":3.4,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11889547/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of the immune cell infiltration patterns in lung adenocarcinoma to facilitate immunotherapy.","authors":"Haili Li, Zanmei Qin, Xuemei Huang, Zuyou Wei, JingMin Deng","doi":"10.1016/j.heliyon.2025.e42720","DOIUrl":"10.1016/j.heliyon.2025.e42720","url":null,"abstract":"<p><p>Although Immunotherapy has emerged as an efficient treatment in lung carcinoma, merely a subset of lung adenocarcinoma (LUAD) patients could be benefited from it. Increasing evidence revealed that tumor immune cell infiltrating (ICI) in the tumor microenvironment (TME) is highly related to patient prognosis and characteristics of the tumor. Thus far, the immune cell infiltration patterns of LUAD remain unclear. Herein, ESTIMATE and CIBERSORT algorithms were conducted to characterize the ICI patterns of 1155 patients with LUAD. Three ICI subtypes were determined, and the ICI score was constructed by performing PCA. A high ICI score group referred to increased activation of the signaling pathways related to immune activation and drug metabolism, reduced tumor mutation burden (TMB), as well as significantly higher expression levels of CTLA-4, PD-1, LAG3, and immune-activation-related genes. Patients who had high ICI scores showed better overall survival (OS) compared to those with low ICI scores, irrespective of TMB status. This study demonstrated that ICI scores serve as an original and effective indicator for independent prognostic prediction as well as customized immune therapy of LUAD. Establishing the ICI patterns of a larger patient population will extend our knowledg of TME, and it may facilitate the development of immunotherapies specific to LUAD.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42720"},"PeriodicalIF":3.4,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11891687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extent of natural soil cadmium, its bioavailability, and pollution treat analysis in the agroforestry systems of the Gedeo Zone of southern Ethiopia.","authors":"Abdelaali Ait Saghir, Fisseha Asmelash, Melesse Maryo, Ali Boularbah, Fassil Kebede","doi":"10.1016/j.heliyon.2025.e42742","DOIUrl":"10.1016/j.heliyon.2025.e42742","url":null,"abstract":"<p><p>The research objectives were to determine extent of soil cadmium (Cd) in the major soil types of the Gedeo Zone of Ethiopia thereby assessing the pollution risk on the environmental health. Four profile pits representing Luvisols, Nitisols, Cambisols, and Leptosols, were excavated and soil samples were collected. Total and available Cd, Cu, Zn, and Mn, including other major soil physicochemical properties, were analyzed in the lab. The permutational multivariate analysis of variance results indicated that the significant (<i>p</i> < 0.05) level of heterogeneity between soil types is confined to subsurface horizons. The nonmetric multidimensional scaling ordination plots also show a marked difference between the physicochemical properties of the subsurface horizons of the Luvisol and the remaining soil types. The mean total Cd levels were high for all soil types and horizons in the range of 5.82-8.48 ppm, however, the mean available Cd contents were low (0.69-0.90 ppm). One-way ANOVA and Kruskal Wallis test results revealed a significant (<i>p</i> < 0.05) soil type effect on total and available Cd contents between the corresponding soil horizons. Based on the single pollution and the Nemerow comprehensive pollution indices, the pollution risk decreases in the order of Cd > Mn > Zn > Cu pollution. According to Pearson's correlation results, no correlation exists between total and available Cd, whereas very strong and significant (<i>p</i> < 0.05) correlations are present between total Cd and total nitrogen (<i>r</i> = 0.90), electrical conductivity (<i>r</i> = 0.83), and organic matter (<i>r</i> = 0.77). Our results indicate that Cd contamination is of geogenic origin, further aggravated by organic matter amendments. More research are needed, among other things, to know the Cd status of the major crops grown in the area so as to design appropriate Cd management strategies.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42742"},"PeriodicalIF":3.4,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11891679/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chloro-substituted metallo-phthalocyanines (TiPcCl₂, MnPcCl, InPcCl, AlPcCl) applied to organic devices.","authors":"María Elena Sánchez Vergara, Mariana Gonzalez Vargas, Emilio I Sandoval Plata, Alejandro Flores Huerta","doi":"10.1016/j.heliyon.2025.e42697","DOIUrl":"10.1016/j.heliyon.2025.e42697","url":null,"abstract":"<p><p>Chlorinated phthalocyanines-TiPcCl₂, MnPcCl, InPcCl, and AlPcCl-were studied as organic semiconductors and, in this framework, their behavior as a buffer layer. Initially, these metallophthalocyanines were characterized in solution using UV-visible spectroscopy to determine their optical band gaps, with results compared to density functional theory (DFT) calculations. The phthalocyanines were subsequently deposited as films via high-vacuum sublimation, and optically characterized to assess their reflectance and band gaps using the Kubelka-Munk function, with the lowest band gap for MnPcCl of 1.67 eV. Morphological and mechanical characterization revealed the Knoop hardness in the range of 10-15 HK for all films, and a tensile strength highest for the InPcCl film, of 9.3x10^-3 Pa. Fluorescence analysis revealed peak emission around 438 nm, corresponding to blue light. Among the compounds, InPcCl exhibited the highest emission intensity, followed by TiPcCl₂, AlPcCl, and MnPcCl. The metal at the center of chlorinated phthalocyanines was found to exert a determining effect on the properties of semiconductor films. Finally, single-layer devices were fabricated and examined under various illumination conditions to analyze their current-voltage (I-V) and power-voltage (P-V) characteristics and their electrical conductivity across different temperatures. The highest power obtained in the devices was 2.78 mW, while the highest electrical conductivity was 6.6x10^-2 S/cm, which suggests the potential employment of these films for use in organic optoelectronics as semiconductors and buffer layers.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42697"},"PeriodicalIF":3.4,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11883404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cisplatin-loaded UiO-66-NH₂ functionalized with folic acid enhances apoptotic activity and antiproliferative effects in MDA-MB-231 breast and A2780 ovarian cancer cells: An <i>in vitro</i> study.","authors":"Zahra Sadeghi Jam, Farzaneh Tafvizi, Parvin Khodarahmi, Parvaneh Jafari, Fahimeh Baghbani-Arani","doi":"10.1016/j.heliyon.2025.e42685","DOIUrl":"10.1016/j.heliyon.2025.e42685","url":null,"abstract":"<p><p>The multifunctional nature of UiO-66-NH₂ as a drug carrier positions it as an optimal candidate for encapsulating and delivering anticancer agents. This study developed a folic acid (FA)-functionalized metal-organic framework (MOF) based on UiO-66-NH₂ to facilitate the targeted delivery of cisplatin (CIS) to MDA-MB-231 breast cancer and A2780 ovarian cancer cells. Fourier transform infrared spectroscopy (FT-IR) confirmed the successful encapsulation of CIS within UiO-66-NH₂, while the drug release profile demonstrated a sustained, pH-responsive release of CIS, with a pronounced increase in the acidic tumor microenvironment. The MTT assay revealed excellent biocompatibility of UiO-66-NH₂-FA with HFF healthy cells, whereas UiO-66-NH₂-CIS-FA significantly enhanced anticancer activity against MDA-MB-231 and A2780 cells. Treatment with UiO-66-NH₂-CIS-FA induced substantial apoptosis in both cell lines, leading to a marked upregulation of <i>BAX</i> and <i>P53</i> gene expression, alongside the downregulation of <i>BCL2, CCND1,</i> and <i>CDK4.</i> Furthermore, cells treated with CIS, UiO-66-NH₂-CIS, and UiO-66-NH₂-CIS-FA exhibited a significant increase in DCF fluorescence compared to the control group, indicating elevated ROS generation. UiO-66-NH₂-CIS-FA demonstrated enhanced drug-loading capacity and cytotoxic efficacy against cancer cells. Functionalization of UiO-66-NH₂-CIS with FA presents a promising strategy for targeted cancer therapy by improving drug delivery specificity and enhancing therapeutic outcomes.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42685"},"PeriodicalIF":3.4,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11904574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in the clinical management of intoxication by five heavy metals: Mercury, lead, chromium, cadmium and arsenic.","authors":"Mahdi Balali-Mood, Nastaran Eizadi-Mood, Hossein Hassanian-Moghaddam, Leila Etemad, Mohammad Moshiri, Maryam Vahabzadeh, Mahmood Sadeghi","doi":"10.1016/j.heliyon.2025.e42696","DOIUrl":"10.1016/j.heliyon.2025.e42696","url":null,"abstract":"<p><p>Metals have been used for many centuries, but their nutritional and toxic effects have been investigated since the last century. The common toxic heavy metals (THM) include mercury, lead, chromium cadmium, and arsenic. As human exposure to THM increasingly causes systemic and organ complications, it seems required to review the recent advances of treatment of the toxic metals. Despite the current knowledge of the hazards of heavy metals, there is still high incidents of their poisonings particularly in developing countries. In this review, after an introduction, we briefly describe the routes of exposure, clinical features and prognosis of each metal poisoning. Then, review the different treatments for each metal with particular attention to recent advances in the treatment of both acute and chronic poisonings. The main antidotes for all THM are still chelating agents, but new agents were developed over the past decades and have been used successfully for the THM poisonings. Dimercaptosuccinic acid (DMSA) known as succimer has been prescribed as a safe oral chelator in lead poisoning. Similarly, dimercapto-propanesulfonic acid (DMPS) has also revealed fewer side effects than the old chelating agents. The two are currently gaining increased acceptance among clinical toxicologists. However, there is no specific antidote for mercury poisoning. Dimercaprol is almost no longer used as an antidote of choice in the treatment of chronic THM poisoning. Comparison of clinical management of intoxication by the five heavy metals reveals similar treatment strategies. On the other hand, some of them require specific interventions to reduce the toxicity. Because of drawbacks in the application of commonly known chelating agents, treatment with bioactive compounds which have antioxidant and anti-inflammatory properties has been the subject of much interest in recent research. However, despite the promising results observed in experimental animals, clinical trials on their clinical therapeutic benefits have not been yet successful and need further studies to determine their efficacy and safety in humans. Development of less toxic chelating agents are still under investigations. Moreover, the development of orally administrable chelating agents for home health care would likely be of great interest for future research.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42696"},"PeriodicalIF":3.4,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11876891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic potential of microalgae-derived natural compounds in diabetic wound healing: A comprehensive review.","authors":"Jinjin Pei, Simab Kanwal, Ramachandran Sivaramakrishnan, Kasinee Katelakha","doi":"10.1016/j.heliyon.2025.e42723","DOIUrl":"10.1016/j.heliyon.2025.e42723","url":null,"abstract":"<p><p>A variety of cell types and chemical systems are known to interact throughout the complex process of wound healing. In addition to being very uncomfortable for patients, wounds that do not heal properly or become chronic can place a heavy burden on society. The creation of novel treatment approaches can expedite the healing process, reduce the societal burden, and improve patient outcomes. Due to advancements in the field of biomedical science, microalgae have significant potential for use in diabetic wound healing and other wound healing applications. This review delves into the physiological process of wound healing, the use of microalgae in wound healing, and a detailed explanation of the wound healing roles of various microalgal originated bioactive compounds including alginate, pigments, fatty acids, proteins, polysaccharides, flavonoids and phenols. The study discusses the efficacy of photosynthetic hydrogels in drugs and oxygen delivery to the wounded area that is crucial for promoting a good healing process, as well as highlights the drawbacks and challenges involved in using microalgae for wound healing. Given the current state of the art in utilizing microalgae for wound care, this review provides new perspectives for further research, along with insightful advice and innovative suggestions for academics engaged in this area.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42723"},"PeriodicalIF":3.4,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11876918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing mineral transportation systems in underground mines: A framework for capacity analysis.","authors":"Mohammad Javad Rahimdel, Reza Mohammadpour","doi":"10.1016/j.heliyon.2025.e42708","DOIUrl":"10.1016/j.heliyon.2025.e42708","url":null,"abstract":"<p><p>The transportation of materials in mining constitutes more than half of the operating costs. The efficient operation of mineral transportation systems significantly influences the production capacity and cost-effectiveness of mining operations. The occurrence of unavoidable failures within these systems presents a substantial production risk. Consequently, investigating the primary causes of failures and assessing the resulting production losses due to operational interruptions have become critical issues in mining engineering. However, there have been limited studies on the capacity analysis of mining operations through the failure analysis of mineral transportation systems. In response to this challenge, this paper introduces an enhanced framework for conducting capacity analysis of mineral production in underground mining operations using Fault Tree Analysis (FTA) and Event Tree (ET), which are well-established techniques in risk management. Given the lack of sufficient data, FTA can be applied to problems within a fuzzy environment. The proposed framework integrates FTA and ET within a fuzzy logic context to comprehensively evaluate system performance. By conducting a case study on a mineral transportation risk assessment at the Qaleh-Zari underground copper mine, the effectiveness of this approach is demonstrated. In this study, all potential scenarios that could lead to mineral transportation failures were identified, and the risks associated with each scenario, as well as the overall risk to the system, were assessed to evaluate potential production losses. The results of this study provide valuable guidance to mine managers, directors, and contractors, enabling them to optimize operational procedures, enhance equipment safety, and effectively mitigate risks associated with mineral production during underground mining operations.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42708"},"PeriodicalIF":3.4,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11883358/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of vector preferential settling in the dynamics of a plant virus model with latent periods.","authors":"Kimben M Gonzales, Juancho A Collera","doi":"10.1016/j.heliyon.2025.e42707","DOIUrl":"10.1016/j.heliyon.2025.e42707","url":null,"abstract":"<p><p>Insect vectors transmit many plant viruses of agricultural importance. In most cases, these viruses manipulate their vectors' behavior and movement leading to vector settling and feeding preferences that influence virus spread. The latent period within the insect vector is also crucial in virus transmission during vector feeding, however is assumed to be negligible in previous studies. This paper proposes a plant-virus model with a focus on vector settling preference for virus-infected plants and considers the latent periods in both the plant and insect vector populations by introducing them as time delays. We analyze the existence and local stability of the equilibrium solutions using the basic reproduction number of the proposed model which is inversely related to the saturation parameter due to vector preference. We investigate the effects of the time delays on the local stability of equilibria and the possible emergence of stable limit-cycle solutions. Moreover, our theoretical results are corroborated using numerical continuation and bifurcation analysis to provide more insights into how the latent periods and vector preference affect the system's dynamics. Particularly, we show numerically that increasing the saturation parameter due to preferential settling reduces the number of new infections, if not eradicates the infection in the system.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42707"},"PeriodicalIF":3.4,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11891715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Iranian sentiments on the Paris Agreement: Insights from Twitter.","authors":"Faeze Atefinia, Seyed Reza Mirnezami","doi":"10.1016/j.heliyon.2025.e42716","DOIUrl":"10.1016/j.heliyon.2025.e42716","url":null,"abstract":"<p><p>Iran remains one of the few nations not fully committed to the Paris Agreement and public opinion regarding implementation of policies serves a significant role. This study examines the general sentiment of Iranian Twitter users towards the Paris Agreement. A total of 25,386 tweets were collected and analyzed, revealing that discussions around the Paris Agreement predominantly centred on terms such as 'electricity', 'shameful', 'government', and 'America'. The majority of these tweets coincided with the power outages in January, June, and July 2021, as well as the period following Trump's withdrawal from the Paris Agreement in June 2017. To gain deeper insights into the level of support for the Paris Agreement in Iran, a thematic analysis was conducted on a random sample of 500 tweets, selected based on the theoretical saturation of themes and sub-themes. The analysis revealed that 8 % of users expressed a positive orientation, 60 % a negative orientation, and 32 % a neutral orientation towards the Paris Agreement. The thematic analysis suggests that the negative sentiment is primarily due to frequent power outages, perceived inefficiency and lack of trust in government decisions, lack of transparency, and the perceived colonial nature of the agreement for developing countries. The findings underscore the importance of garnering public support in developing countries for international environmental agreements.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42716"},"PeriodicalIF":3.4,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11876869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}