Wiley最新文献

{"title":"NtDEAH1 Modulates Gibberellin Receptor NtGID1 Expression and Negatively Regulates Leaf Number in Tobacco.","authors":"Kai Pi, Ting Liang, Qiwei Yu, Zhenbao Luo, Jiajun Luo, Lili Duan, Jingyao Zhang, Renxiang Liu","doi":"10.1111/pce.70246","DOIUrl":"https://doi.org/10.1111/pce.70246","url":null,"abstract":"<p><p>Tobacco (Nicotiana tabacum L.) is a crop of major economic importance worldwide and also a widely used model in plant biology and genetics. Leaf number (LN) is a key agronomic trait that determines yield. To elucidate its genetic basis, we developed a mapping population by crossing the low-leaf, high-quality cultivar 'NC82' with the high-leaf cultivar 'Jiucaiping No.2' (JCP2). Bulked segregant analysis initially placed the locus controlling LN within a 6.16 Mb region on chromosome 9. The integration of competitive allele-specific PCR markers with RNA sequencing data narrowed down this region and identified a single candidate gene, NtDEAH1. Overexpression of NtDEAH1 in both NC82 and JCP2 backgrounds significantly reduced LN, whereas CRISPR/Cas9-mediated knockout increased LN, indicating that NtDEAH1 acts as a negative regulator of LN and is a previously unreported control factor. Transcriptomic profiling and phytohormone analyses revealed that NtDEAH1 modulates the expression of genes in the gibberellin pathway. Specifically, NtDEAH1 binds to the 5'-untranslated region of the gibberellin receptor gene NtGID1, thereby influencing mRNA stability and translational efficiency to regulate LN. These findings provide new insights into genetic and molecular mechanisms underlying LN determination, and suggest that NtDEAH1 may serve as a target for future breeding aimed at optimising plant architecture and enhancing yield.</p>","PeriodicalId":222,"journal":{"name":"Plant, Cell & Environment","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145311968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Five Orders of Cascaded Raman Fibre Laser Oscillation From 1550 nm to Mid-IR at 2334 nm Wavelength","authors":"Boris Levit,&nbsp;Alexander Bekker,&nbsp;Baruch Fischer","doi":"10.1049/ell2.70448","DOIUrl":"https://doi.org/10.1049/ell2.70448","url":null,"abstract":"<p>We demonstrate a cascaded Raman fibre laser (RFL) oscillation up to the fifth order Stokes wave, from ∼1550 nm to mid-IR at 2334 nm, with silica fibres. The pumping was done with an amplified spontaneous emission (ASE) light of erbium-doped fibre (EDF) in the 1550 nm wavelength regime. The low orders (first to third) could be easily obtained in continuous wave (CW) mode, while the fourth and fifth orders were obtained in a pulse mode. We used highly nonlinear fibres that allowed relatively short fibre cavity lengths of (10-100)m.</p>","PeriodicalId":11556,"journal":{"name":"Electronics Letters","volume":"61 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ietresearch.onlinelibrary.wiley.com/doi/epdf/10.1049/ell2.70448","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145317351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimally Invasive Treatment of Left Renal Staghorn Calculus After Orthotopic Neobladder Surgery: A Case Report and Literature Review","authors":"Xiaozhi Shi,&nbsp;Wei Li,&nbsp;Fei Gao,&nbsp;Yongan Wen","doi":"10.1002/ccr3.71029","DOIUrl":"https://doi.org/10.1002/ccr3.71029","url":null,"abstract":"<p>A 60-year-old male with left renal staghorn calculi post orthotopic neobladder surgery was treated via retroperitoneal laparoscopic pyelolithotomy plus flexible ureteroscopic holmium laser lithotripsy, achieving full stone clearance.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 10","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.71029","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145317451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genome-wide association study and polygenic risk scores of eosinophilia in Taiwan","authors":"Hsing-Fang Lu,&nbsp;Su Boon-Yong,&nbsp;Chi-Ya Yang,&nbsp;Jiu-Yao Wang,&nbsp;Yen-Ting Chang,&nbsp;Fuu-Jen Tsai","doi":"10.1002/cti2.70050","DOIUrl":"https://doi.org/10.1002/cti2.70050","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Eosinophilia, characterised by elevated eosinophil levels, is associated with various allergic and inflammatory conditions. This study aimed to elucidate the genetic determinants of eosinophil levels by examining polygenic risk scores (PRS) and identifying significant single nucleotide polymorphisms (SNPs).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a comprehensive genome-wide association study (GWAS) on eosinophil levels using a large cohort, comprising 221 851 controls (eosinophil levels ≤ 5%) and 11 200 cases (eosinophil levels &gt; 5%) in Taiwan. The analysis included covariates such as age, sex and the first 10 principal components to account for population stratification. Polygenic risk scores were calculated, and their associations with eosinophil levels were evaluated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The control group exhibited a mean eosinophil level of 47.81 (SD, 21.08) and was composed of 55.32% females and 44.68% males. The case group had a mean eosinophil level of 43.27 (SD, 22.27) and consisted of 38.6% females and 61.4% males. The GWAS identified several SNPs with significant associations, including rs7646596, rs8191981, rs140105250, rs77143352, rs12535759, rs11327184, rs16917546, rs76738175, rs11568075, rs9557175 and rs2801127, with rs7646596 showing the most significant <i>P</i>-value. PRS analysis indicated that individuals with higher polygenic risk scores were significantly more likely to have elevated eosinophil levels.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study identified several genetic loci significantly associated with eosinophil levels, highlighting the polygenic nature of eosinophilia. The robust associations, particularly with SNP rs7646596, offer valuable insights into the genetic underpinnings of eosinophilia and related conditions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":152,"journal":{"name":"Clinical & Translational Immunology","volume":"14 10","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cti2.70050","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145317753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Front Cover: Wearable Self-Powered Biosensor for Continuous Lactate Monitoring in Sweat (ChemElectroChem 20/2025)","authors":"Isao Shitanda,&nbsp;Takeru Samori,&nbsp;Mizuki Satake,&nbsp;Noya Loew,&nbsp;Masahiro Motosuke,&nbsp;Takahiro Mukaimoto,&nbsp;Shinya Yanagita,&nbsp;Tatsunori Suzuki,&nbsp;Tsutomu Mikawa,&nbsp;Seiya Tsujimura,&nbsp;Hikari Watanabe,&nbsp;Masayuki Itagaki","doi":"10.1002/celc.70076","DOIUrl":"https://doi.org/10.1002/celc.70076","url":null,"abstract":"<p><b>The Front Cover article</b> presents a wearable paper-based biofuel cell that enables self-powered monitoring of sweat lactate levels via a low-power wireless transmission device. More information can be found in the Research Article by Isao Shitanda, Noya Loew, and co-workers (DOI: 10.1002/celc.202500222).\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":142,"journal":{"name":"ChemElectroChem","volume":"12 20","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/celc.70076","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145297068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issue Information: (Adv. Sci. 39/2025)","authors":"","doi":"10.1002/advs.71953","DOIUrl":"https://doi.org/10.1002/advs.71953","url":null,"abstract":"","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"12 39","pages":""},"PeriodicalIF":14.1,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/advs.71953","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145297295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-Equilibrium Magnon Engineering Enabling Significant Thermal Transport Modulation (Adv. Funct. Mater. 40/2025)","authors":"Takamasa Hirai,&nbsp;Toshiaki Morita,&nbsp;Subrata Biswas,&nbsp;Jun Uzuhashi,&nbsp;Takashi Yagi,&nbsp;Yuichiro Yamashita,&nbsp;Varun Kumar Kushwaha,&nbsp;Fuya Makino,&nbsp;Rajkumar Modak,&nbsp;Yuya Sakuraba,&nbsp;Tadakatsu Ohkubo,&nbsp;Rulei Guo,&nbsp;Bin Xu,&nbsp;Junichiro Shiomi,&nbsp;Daichi Chiba,&nbsp;K. Uchida","doi":"10.1002/adfm.71679","DOIUrl":"https://doi.org/10.1002/adfm.71679","url":null,"abstract":"<p><b>Magnon Engineering</b></p><p>The collective motion of spins provides a new principle “magnon engineering” for actively controlling heat flow in solids, paving the way for thermal management technologies using magnetic materials. More information can be found in the Research Article by Takamasa Hirai and co-workers (10.1002/adfm.202506554).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"35 40","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/adfm.71679","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145297462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacological Microglial Inhibition Remodels the Scar Microenvironment to Support Reticulospinal Circuit Reconstruction After Spinal Cord Injury.","authors":"Run Li, Hongyuan Xing, Yifan Shen, Meng Chen, Bowen Lyu, Xiaofeng Yang, Li Sun, Chao Jiang, Jianyu Lv, Xin Ding, Zhongyang Gao, Yue Wang","doi":"10.1002/advs.202503966","DOIUrl":"https://doi.org/10.1002/advs.202503966","url":null,"abstract":"<p><p>Due to an inhibitory scar microenvironment that prevents neural circuit reconstruction, spinal cord injury (SCI) often leads to persistent neurological dysfunction. Although neonatal murine models demonstrate that microglial inhibition enables scar remodeling to support neuroregeneration and functional recovery, effective pharmacological suppression of microglial activation in adult SCI remain elusive. Here, this work demonstrates that early β2-adrenergic receptor agonist treatment drives microglial transition to a homeostatic phenotype within the post-SCI scar. This intervention reduces inhibitory extracellular matrix deposition and transforms the inhibitory microenvironments into permissive substrates for axonal regrowth. Anatomical analyses reveal regeneration of the reticulospinal tract, which establishes synaptic connectivity with thoracolumbar circuits to mediate motor recovery in a complete SCI. These findings elucidate the therapeutic potential and neural circuit mechanisms underlying pharmacological microglial modulation for SCI repair, establishing a glial-neural circuit reparative paradigm.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e03966"},"PeriodicalIF":14.1,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145306351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BRIGHT Enables High-SNR Live-Cell Imaging of Non-Repetitive Sequences via Bivalent Fluorescent Nanobody-Mediated Cascade-Dependent Illumination.","authors":"Lei Feng, Tao Huang, Yanxi Han, Meng Tian, Duo Wang, Zilong Mei, Yu Ma, Yingshuo Ma, Jinming Li, Rui Zhang","doi":"10.1002/advs.202513014","DOIUrl":"https://doi.org/10.1002/advs.202513014","url":null,"abstract":"<p><p>Genomic loci and genome-independent DNA exhibit heterogeneous dynamics related to physiological function. Live-cell imaging of non-repetitive sequences is essential but limited by low signal-to-noise ratio (SNR), restricting accurate identification and dynamic tracking. Here, the development of a BRIGHT (bivalent near-infrared nanobody-mediated cascade illumination of genomic loci for high-SNR tracking) system for non-repetitive sequence live imaging is reported. BRIGHT employs dCas9-n×ALFA to target genomic loci and realizes high SNR by triggering cascade-dependent illumination via bivalent binding and antigen-dependent illumination of a bivalent near-infrared fluorescent nanobody targeting ALFA tags (Bi-NIR-Fb_ALFA). BRIGHT achieves ≈6.26-fold and ≈6.76-fold higher SNR than SunTag and PP7-PCP in telomere labeling, and enables non-repetitive DNA imaging with SNR up to 284.84. Furthermore, BRIGHT tracks chromatin dynamics comparably to previous tools, links dynamics and nuclear positioning to transcriptional activity, and detects the distribution and dynamic heterogeneity of extrachromosomal circular DNA (eccDNA). Overall, BRIGHT dramatically improves the SNR of non-repetitive sequence imaging and offers an innovative tool for studying genomic dynamics and gene regulation.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e13014"},"PeriodicalIF":14.1,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145306406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic Modulation of OECT-Based Inverters for In Situ Electrophysiological Monitoring.","authors":"Guohong Hu, Qijun Cai, Zhenglei Liu, Rongsheng Zeng, Liang-Wen Feng, Jianhua Chen, Shiji Xiahou, Wei Huang","doi":"10.1002/advs.202512755","DOIUrl":"https://doi.org/10.1002/advs.202512755","url":null,"abstract":"<p><p>Organic electrochemical transistors (OECTs) and their related circuits have emerged as a promising platform for biosensors and neuromorphic electronics, benefiting from their sub-1 V operation voltage, flexibility, biocompatibility, etc. However, operation instability, induced by complex microstructure variations and undesired side reactions during repeated redox processes, poses tremendous challenges for reliable and robust functions. Here, a dynamic modulating system is presented that can actively control the working condition of an OECT-based inverter and maintain high-voltage amplification capability through real-time voltage transfer characteristic scanning and operating voltage adjustment. Especially, under system modulation, the inverter maintains a high-voltage amplification capability with a voltage gain >34.58 V V^-1. While without modulation (i.e., at a fixed input voltage), the voltage gain rapidly deteriorates to 3.11 V V^-1. Thereafter, stretchable complementary circuits are fabricated and integrated with this system to enable high-fidelity in situ monitoring of the electrooculogram with >32.59 dB signal-to-noise ratio for more than 90 min, thus establishing a reliable wearable biosensing method. This work provides a new strategy to enable highly stable operation of bioelectronics with devices holding inferior stabilities.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e12755"},"PeriodicalIF":14.1,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145306412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}