Wiley最新文献

{"title":"Effects of 6-OHDA-Mediated Chemical Denervation of Sympathetic Axons in Inguinal Subcutaneous White Adipose Tissue.","authors":"Gilian Gunsch, Gargi Mishra, Magdalena Blaszkiewicz, Erica de Sousa, Jake W Willows, Katharine W Alltop, Annemarie Towle, Shawn Collins, Andre Khalil, Isabel F Snodgrass, Lara Agha, Kiran Prakash, Rashmika Maganuru, Sugasini Dhavamani, John W Newman, Kristy L Townsend","doi":"10.1111/dom.71251","DOIUrl":"10.1111/dom.71251","url":null,"abstract":"<p><strong>Aims: </strong>White adipose tissue (WAT) innervation by sensory and sympathetic axons contributes to tissue functions, but the consequences of selectively disrupting sympathetic input to WAT remain incompletely defined.</p><p><strong>Materials and methods: </strong>We utilised 6-hydroxydopamine (6-OHDA) as a validated approach to achieve bilateral sympathetic denervation of mouse inguinal subcutaneous WAT (ing-scWAT) and investigated impacts on adipose and whole-body metabolism.</p><p><strong>Results: </strong>Sympathetic denervation did not impact body weight or adipose mass by 16 days post-denervation but significantly altered energy expenditure. Sympathetic denervation increased both sensory neuropeptide levels and sensory innervation at 7 days, which may explain the minimal whole-body impacts, since sensory nerves can contribute to many of the same metabolic processes as sympathetic nerves in adipose. In acute studies, intra-ing-scWAT norepinephrine delivery increased calcitonin gene related peptide (CGRP) levels in the depot, while CGRP administration reduced norepinephrine levels, underscoring previous reports of nerve cross talk at the tissue level. Multi-omics profiling of sympathetically denervated ing-scWAT revealed selective remodelling of lipid signalling pathways, including accumulation of polyunsaturated fatty acid-derived oxylipins from the cytochrome P450 pathway, alongside perturbations in tricarboxylic acid cycle metabolism. These changes were distinct from CL316,243 treatment. Single-nuclei transcriptomics identified cell-type-specific re-programming, including altered oxidative phosphorylation and lipid metabolic pathways in adipocytes and increased immune cell representation with sympathetic denervation.</p><p><strong>Conclusions: </strong>Together, these data demonstrate that sympathetic denervation of scWAT induces coordinated metabolic, lipidomic, and transcriptional changes in the tissue as well as alterations to energy balance. Nerve crosstalk and potential compensation by sensory axons may help explain the findings.</p>","PeriodicalId":158,"journal":{"name":"Diabetes, Obesity & Metabolism","volume":" ","pages":"10459-10474"},"PeriodicalIF":6.1,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13646377/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148816717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in Cost of Care With Tirzepatide in Adults Aged Over 55 Years With Obesity or Overweight Without Diabetes: A Matched Cohort Analysis.","authors":"Navneet Upadhyay, Ali Bonakdar, Keshab Subedi, Soutrik Banerjee, Benjamin Behrend, Emily R Hankosky","doi":"10.1111/dom.71250","DOIUrl":"10.1111/dom.71250","url":null,"abstract":"<p><strong>Aims: </strong>Compare healthcare cost trends among older adults with obesity or overweight treated with tirzepatide versus no treatment.</p><p><strong>Materials and methods: </strong>Retrospective cohort study using real-world data from US Komodo Research Dataset, 8 November 2022 to 30 September 2025. Adults > 55 years with obesity, or overweight with ≥ 1 weight-related comorbidity, without T2 diabetes who initiated tirzepatide for weight management were compared with propensity score-matched individuals who did not receive any incretin-based therapies. Changes in all-cause healthcare costs (excluding tirzepatide; per-person-per-month) between cohorts were assessed at 3-6, 6-12 and 12-18 months using a difference in differences (DiD) framework. Informative censoring and differential follow-up were addressed with inverse-probability-of-censoring-weights and pairwise censoring.</p><p><strong>Results: </strong>Each cohort comprised 15843 individuals. Healthcare cost DiD estimates (95% CI) for the tirzepatide versus control cohorts were -$145 (-266, -25; 12.3% reduction; p = 0.022) during 6-12 months and -$319 (-544, -94; 25.4% reduction; p = 0.015) during 12-18 months; using pairwise censoring, estimates were -$181 (-319, -43; p = 0.021) and -$607 (-1007, -207; p = 0.023), respectively. Cost offsets with tirzepatide were driven by higher medical costs in controls during 12-18 months (-$211 [-$407, -$15]; p = 0.065) and fewer inpatient/emergency department visits with tirzepatide versus controls; incidence rate ratio (95% CI) 0.69 (0.50, 0.94; p = 0.021) during 12-18 months.</p><p><strong>Conclusions: </strong>Monthly cost offsets for persistent tirzepatide users versus untreated individuals grew over time, offsetting $319 (ranging from $94 to $544) tirzepatide costs by 12-18 months. These results have implications for the $195 monthly net Medicare cost for the Bridge programme, suggesting tirzepatide may generate near-term cost savings in an older population that stays on treatment.</p>","PeriodicalId":158,"journal":{"name":"Diabetes, Obesity & Metabolism","volume":" ","pages":"10418-10427"},"PeriodicalIF":6.1,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13646331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148811499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter: Interpreting Apparent P-CAB Superiority for Antithrombotic-Associated Upper Gastrointestinal Bleeding.","authors":"Xiaoqing Yang, Guihua Zhao","doi":"10.1111/apt.70771","DOIUrl":"10.1111/apt.70771","url":null,"abstract":"","PeriodicalId":121,"journal":{"name":"Alimentary Pharmacology & Therapeutics","volume":" ","pages":"1322-1323"},"PeriodicalIF":6.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148100713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter: More Precise Stratification Is Needed Within Chronic Hepatitis B Virus Low-Level Viraemia.","authors":"Qun Yang, Jie Zheng, Jinheng Cao","doi":"10.1111/apt.70724","DOIUrl":"10.1111/apt.70724","url":null,"abstract":"","PeriodicalId":121,"journal":{"name":"Alimentary Pharmacology & Therapeutics","volume":" ","pages":"1318-1319"},"PeriodicalIF":6.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147865947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MALDI-MSI: Insights Into Plant, Cell and Environment.","authors":"Hua Guo, Ran Wu, Xiaodong Wang","doi":"10.1111/pce.70727","DOIUrl":"10.1111/pce.70727","url":null,"abstract":"","PeriodicalId":222,"journal":{"name":"Plant, Cell & Environment","volume":" ","pages":"8112-8115"},"PeriodicalIF":6.9,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148403175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phosphate Starvation Shapes M⁶A Modification and Poly(A) Tails to Regulate mRNA Decay in Rice.","authors":"Wang Chen, Yanhua Zhu, Ziqi Zhang, Zhujun Wang, Hudong Kuang, Zhaowan Yang, Chenxinyu Tan, Honghui Lin, Jian Yang","doi":"10.1111/pce.70694","DOIUrl":"10.1111/pce.70694","url":null,"abstract":"<p><p>Phosphorus is essential for plant growth and reproduction. Plants have evolved diverse strategies to adapt to fluctuations in inorganic phosphate (Pi) availability by reprogramming gene expression. In addition to transcriptional regulation, RNA decay plays a crucial role in mRNA metabolism. In this study, we investigated whether RNA decay influences mRNA stability and whether m⁶A and m⁵C modifications and poly(A) tails are involved in this process, using Direct RNA sequencing for detection. We successfully established a genome-wide mRNA decay assay in rice and found that mRNA decay rates are primarily determined by G/C content in the 5' UTR, G/C content and RNA secondary structures in the CDS, m⁶A and m⁵C modifications in the 3' UTR, as well as the number of introns and the length of poly(A) tails. Both phosphate-starvation-induced (PSI) and phosphate-starvation-downregulated (PSD) genes decay faster than non-responsive genes, likely due to their higher CDS G/C content, fewer introns, and lower m⁶A modification rates. Pi starvation accelerated the decay of PSI genes but slowed the decay of PSD genes. Nanopore Direct RNA sequencing revealed that m⁶A modification and poly(A) tail length, rather than m⁵C modification, play central roles in regulating mRNA decay under Pi starvation. Furthermore, overexpression of the m⁶A reader OsYTH10 protected m⁶A-modified transcripts of OsPT2 and OsPAP21b from degradation, thereby enhancing Pi accumulation in rice. Collectively, our findings demonstrate that phosphate starvation remodels m⁶A methylations and poly(A) tails to modulate mRNA stability and shape the gene expression landscape in rice.</p>","PeriodicalId":222,"journal":{"name":"Plant, Cell & Environment","volume":" ","pages":"8122-8138"},"PeriodicalIF":6.9,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148417271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Root Exudate Composition Drive the Evolution of Their Ecological Functions Towards Improved Chemical Defense and Plant-Microbe Interactions.","authors":"Huiling Wang, Qing Liu, Huizhen Ma, Yunxia Wang, Guoliang Wang","doi":"10.1111/pce.70737","DOIUrl":"10.1111/pce.70737","url":null,"abstract":"<p><p>Alterations in root exudates and their ecological significance across plant evolutionary divergence time remain elusive due to methodological challenges. Herein, we measured root exudate composition of 20 woody species and assessed its associations with root traits and rhizosphere microbiota to investigate the ecological functions of root exudates throughout plant evolution. The root exudates showed increased richness, polarity, unsaturation and aromaticity with divergence time. Furthermore, fungal richness markedly increased with divergence time, accompanied by the rhizosphere enrichment of copiotrophic bacteria (e.g., Bacteroidota and Actinobacteriota), ectomycorrhizal fungi and several functional microbes. Additionally, competitive root traits (e.g., specific root length and root nitrogen concentration) were positively correlated with exudate richness and chemical complexity in ectomycorrhizal (EcM) trees, whereas they were related to the exudation rates in the arbuscular mycorrhizal (AM) trees. Microbial richness and strategies were closely linked to exudate chemistry, and the exudate-microbe interactions were more tightly coupled in the rhizosphere of EcM trees than in that of the AM trees. Shifts in exudate composition and their associated microbial communities may reflect enhanced chemical defense and rhizosphere communication as plants evolve. These results provide evidence that root strategies extend beyond the root itself to include exudates and the rhizosphere, thereby advancing our understanding of root traits-exudate-microbiota associations across plant evolution.</p>","PeriodicalId":222,"journal":{"name":"Plant, Cell & Environment","volume":" ","pages":"8385-8399"},"PeriodicalIF":6.9,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148443571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photoperiod, Light Quality, and Intensity: Integrated Signalling and Hormonal Crosstalk in the Spatiotemporal Control of Plant Vascular Development.","authors":"Yufei Zhang, Yuexin Wu, Huimin Xu, Xin-Qiang He","doi":"10.1111/pce.70732","DOIUrl":"10.1111/pce.70732","url":null,"abstract":"<p><p>Light acts as both the primary energy source for photosynthesis and a pivotal environmental signal that orchestrates plant growth and developmental transitions. The plant vascular system, comprising xylem, phloem, and cambium, dynamically adjusts its development in response to light intensity, quality, and photoperiod. This review synthesises current knowledge on how light signalling regulates cambial activity, xylem and phloem differentiation, and secondary cell wall formation. We elaborate on the molecular interplay between light signalling components and key vascular developmental regulators. Understanding these mechanisms is crucial for deciphering plant adaptation to variable light environments and holds significant potential for enhancing crop resilience and woody biomass yield in the context of global climate change.</p>","PeriodicalId":222,"journal":{"name":"Plant, Cell & Environment","volume":" ","pages":"8270-8284"},"PeriodicalIF":6.9,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148429470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Single‑Cell Prediction to Non‑Host Immunity: The OsNAC78‑Pir7b Module in Rice.","authors":"Yilan E, Wenquan Bao, Xin Geng","doi":"10.1111/pce.70768","DOIUrl":"10.1111/pce.70768","url":null,"abstract":"","PeriodicalId":222,"journal":{"name":"Plant, Cell & Environment","volume":" ","pages":"8607-8610"},"PeriodicalIF":6.9,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148534680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vascular Tre6P: Key Regulator to Coordinate Metabolic Status With Root Growth and Architecture.","authors":"Ling-Ling Tan, Lu Yao, Song Yang","doi":"10.1111/pce.70774","DOIUrl":"10.1111/pce.70774","url":null,"abstract":"","PeriodicalId":222,"journal":{"name":"Plant, Cell & Environment","volume":" ","pages":"8676-8678"},"PeriodicalIF":6.9,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148547364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}