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{"title":"Temporal Niche Modulates Species Interaction Under Thermal Fluctuations","authors":"Shih-Fan Chan,&nbsp;Sheng-Feng Shen","doi":"10.1111/gcb.70491","DOIUrl":"10.1111/gcb.70491","url":null,"abstract":"<div>\u0000 \u0000 <p>Global environmental change is reshaping thermal environments by increasing mean temperatures and altering diurnal temperature range (DTR) in complex, region-specific ways. Climate change, deforestation, and urbanization influence DTR with varying effects. How species with different daily temporal niches respond to such changes remains largely unexplored, particularly regarding interspecific interactions. We synthesize emerging evidence and develop a theoretical framework integrating thermal performance curves with temporal niche theory to address this critical knowledge gap. Our analysis shows that larger DTRs decrease the optimal mean temperatures for diurnal species, while increasing them for nocturnal species. Contrary to conventional views that temporal partitioning reduces competition, we show that DTR changes alter exploitative competition between temporally segregated species sharing common resources. This mechanism operates in diverse systems, from carrion competition between necrophagous insects to growth competition between plants with different photosynthetic pathways. Our framework provides mechanistic insights into how DTR changes affect biodiversity through altered competitive interactions and highlights the need to incorporate these dynamics into vulnerability assessments and conservation planning in the Anthropocene.</p>\u0000 </div>","PeriodicalId":175,"journal":{"name":"Global Change Biology","volume":"31 9","pages":""},"PeriodicalIF":12.0,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145043811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of a Functionalized Bicyclo[3.2.1]Octane: A Common Subunit to Kauranes, Grayananes, and Gibberellanes.","authors":"Nicolas Fay, Camil Benbouziyane, Cyrille Kouklovsky, Aurélien de la Torre","doi":"10.1002/chem.202502441","DOIUrl":"https://doi.org/10.1002/chem.202502441","url":null,"abstract":"<p><p>Kauranes, grayananes, and gibberellanes are three important diterpenoid families. These natural products all share a bicyclo[3.2.1]octane skeleton, with oxidation at very specific positions. In this manuscript, we describe the synthesis of a bicyclo[3.2.1]octane building block, which could serve as a potential intermediate for the synthesis of natural products from these three families. A first approach relying on a 1,4-sila-Prins cyclization was first explored, which required the selective functionalization of dihydrocarvone (via C─H activation and selective oxidation). This strategy resulted in a dead end when a 1,2-cyclization product was obtained. An alternative strategy relying on ring-closing metathesis (RCM) allowed to successfully achieve the synthesis of the desired scaffold in 8 steps from cyclohexenone.</p>","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e02441"},"PeriodicalIF":3.7,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145051470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical outcomes for neoadjuvant immunochemotherapy or chemotherapy versus concurrent chemoradiotherapy in limited-stage small-cell lung cancer: A retrospective, multi-center, real-world study.","authors":"Zichen Zhao, Hao Rong, Mengxia Li, Yong Xu, Long Tian, Xiaoming Qiu, Hu Liao, Yalun Li, Ke Wang, Xiaojun Tang, Panwen Tian, Daxing Zhu, Qinghua Zhou, Yan Zhang","doi":"10.1002/ijc.70153","DOIUrl":"https://doi.org/10.1002/ijc.70153","url":null,"abstract":"<p><p>The clinical value of neoadjuvant immunochemotherapy in limited-stage small-cell lung cancer (LS-SCLC) remains poorly defined, with limited comparative data available against concurrent chemoradiotherapy (CCRT). This retrospective multicenter study evaluated the efficacy and safety of neoadjuvant immunochemotherapy, chemotherapy, and CCRT in treatment-naive patients with potentially resectable SCLC. A total of 139 patients treated between February 2019 and December 2023 were included: 55 received CCRT, and 84 underwent neoadjuvant therapy followed by surgery (28 immunochemotherapy, 56 chemotherapy). Complete (R0) resection was achieved in all surgical cases. The pathological complete response (pCR) rate was significantly higher in the immunochemotherapy group than in the chemotherapy group (35.7% vs. 7.1%, p < .05), as was the major pathological response (MPR) rate (53.6% vs. 12.5%, p < .05). Adverse events were acceptable in the three groups. After propensity score matching (PSM), 24 patients from each group were included for survival analysis. Although median progression-free survival (PFS) and overall survival (OS) were not reached in the immunochemotherapy group, Kaplan-Meier analysis showed significantly prolonged PFS and OS compared with both chemotherapy and CCRT. These results suggest that neoadjuvant immunochemotherapy is a safe and effective treatment strategy for LS-SCLC and merits further investigation in prospective trials.</p>","PeriodicalId":180,"journal":{"name":"International Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145051516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pleiotropy and the Increasing Complexity of Parkinson's Disease Genetics.","authors":"Jonggeol Kim, Joshua M Shulman","doi":"10.1002/ana.78036","DOIUrl":"https://doi.org/10.1002/ana.78036","url":null,"abstract":"","PeriodicalId":127,"journal":{"name":"Annals of Neurology","volume":" ","pages":""},"PeriodicalIF":7.7,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145051446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Directing Effects of Silyl and Germyl Groups in Transition-Metal-Catalyzed Allylic Substitution.","authors":"Daniel Brösamlen, Martin Oestreich","doi":"10.1002/chem.202502196","DOIUrl":"https://doi.org/10.1002/chem.202502196","url":null,"abstract":"<p><p>Transition-metal-catalyzed allylic substitution is a well-established strategy for the formation of carbon-carbon and carbon-heteroatom bonds. However, most methods remain incompatible with unsymmetrical 1,3-disubstituted allylic electrophiles as regioselectivity becomes difficult to control when the substituents are electronically and sterically similar. Achieving simultaneous control over the enantio- and regioselectivity as well as the alkene geometry poses an even greater challenge. To address this, sterically and electronically influential main-group elements such as carbon's heavier homologues silicon and germanium have been strategically incorporated. These metalloids can steer the bond formation away from their proximity enabling the formation of a single regioisomer while also serving as versatile linchpins for further functionalization. This Concept summarizes the key advancements made in the field since the discovery of the allylic substitution with a particular focus on silyl- and germyl-directed strategies that have expanded the synthetic utility of this highly valuable transformation.</p>","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e02196"},"PeriodicalIF":3.7,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145051467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatially Resolved 2D Laser Writing on Graphene Using Diazonium Salts.","authors":"Johanna Krüger, Tamara Nagel, Bowen Yang, Frank Hauke, Andreas Hirsch","doi":"10.1002/chem.202502468","DOIUrl":"https://doi.org/10.1002/chem.202502468","url":null,"abstract":"<p><p>We present the first investigation of precise laser-guided patterning, functionalization, defunctionalization, and refunctionalization of single-layer graphene (SLG) with three different aryl diazonium salts. Using scanning Raman microscopy (SRM) we confirmed the spatially resolved nature of the functionalization. We systematically investigated the influence of key laser parameters (power, irradiation time, and wavelength) and the electronic effects of the substituents on both the functionalization efficiency and integrity of graphene. Our solid-phase approach unequivocally demonstrates that laser-triggered covalent attachment can achieve high functionalization levels comparable to solution-based methods. We also unveil a novel laser-induced defunctionalization pathway at high laser powers and prolonged irradiation times, which allows for the precise, patterned functional group \"erasure\" - a significant advantage over nonselective thermal annealing. Furthermore, we successfully demonstrate the successful readdressing and refunctionalization of these laser \"erased\" areas, enabling a complete \"write-erase-rewrite\" cycle. This work establishes a robust and highly adaptable platform for creating complex, mixed-functionalized graphene architectures with micrometer precision.</p>","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e02468"},"PeriodicalIF":3.7,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145051479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fertility counseling for reproductive-age women with cancer should address gestational carriers","authors":"Carrie Printz","doi":"10.3322/caac.70031","DOIUrl":"https://doi.org/10.3322/caac.70031","url":null,"abstract":"&lt;p&gt;Major cancer organizations, including the American Society of Clinical Oncology and the National Comprehensive Cancer Network, recommend that all reproductive-age women with cancer should receive fertility counseling. Certain cancer treatments, particularly those for women with breast or gynecological cancers, can affect fertility and make it more difficult for women to conceive. Upon receiving fertility counseling before cancer treatment, some patients may decide to freeze their oocytes or embryos for future in vitro fertilization (IVF). Others may not seek family planning help until after receiving chemotherapy or pelvic radiation, which can damage their ability to have biological children.&lt;/p&gt;&lt;p&gt;Women in both groups may turn to gestational carriers, also called surrogates, to carry a child for them through IVF. Gestational carriers may be the only option for patients whose uterus was removed or damaged during cancer treatment.&lt;/p&gt;&lt;p&gt;In a study published in &lt;i&gt;Cancer&lt;/i&gt; (doi:10.1002/cncr.35844), researchers sought to further characterize the role of gestational carriers among reproductive-age women diagnosed with cancer. The study assessed which patients used gestational carriers and how often, as well as their pregnancy outcomes.&lt;/p&gt;&lt;p&gt;Researchers used data from eight statewide cancer registries linked with the Society for Assistive Reproductive Technology Clinic Outcomes Reporting System (SART CORS). Reporting IVF cycles is federally mandated, and SART CORS includes information from more than 90% of US clinics. Drawing on these data, investigators assessed a retrospective cohort of women with a cancer diagnosis who subsequently initiated IVF procedures from 2004 to 2018.&lt;/p&gt;&lt;p&gt;The statewide cancer registries were in Arizona, California, Colorado, Massachusetts, Maryland, North Carolina, New York, and Virginia. Each state has a high number of IVF cycles performed annually and 1000 or more IVF-assisted births each year.&lt;/p&gt;&lt;p&gt;Modified Poisson models were used to estimate prevalence rates and 95% confidence intervals (CI). Discrete Cox regression models were used to calculate the hazard ratio and CI. Multivariable models were adjusted for age, state, and calendar year.&lt;/p&gt;&lt;p&gt;Of the 1095 women diagnosed with cancer who used IVF with cryopreserved embryos or oocytes, 19.1% worked with a gestational carrier. Women involved gestational carriers more often when they were initiating IVF for fertility preservation rather than after their cancer treatment. Those who had chemotherapy versus no chemotherapy also were more likely to use gestational carriers. In addition, the use of donor oocytes or embryos was more common in women who worked with a gestational carrier.&lt;/p&gt;&lt;p&gt;In the sample, 156 women were diagnosed with gynecologic cancer, with 89 having possibly threatened fertility related to surgery or pelvic radiation. In this group, 14.6% (&lt;i&gt;n&lt;/i&gt; = 13) initiated IVF before treatment, with 12 ultimately using a gestational carrier. In the group th","PeriodicalId":137,"journal":{"name":"CA: A Cancer Journal for Clinicians","volume":"75 5","pages":"365-367"},"PeriodicalIF":232.4,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://acsjournals.onlinelibrary.wiley.com/doi/epdf/10.3322/caac.70031","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145038285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Clinical Study of 2253 Cases of Primary and Secondary Defects Associated With Non-Syndromic Orofacial Clefts in Somalia: The First Report of Charity Operation by the Bela Risu Foundation in Somalia","authors":"Martin Kamau,&nbsp;Krishan Sarna,&nbsp;Symon Guthua,&nbsp;Khushboo Jayant Sonigra,&nbsp;Paul Kimani","doi":"10.1111/cga.70023","DOIUrl":"https://doi.org/10.1111/cga.70023","url":null,"abstract":"<div>\u0000 \u0000 <p>Cleft lip and/or palate deformities impose a significant burden on families, particularly in low-income communities. Somalia, characterized by an under-resourced healthcare system, encounters unique healthcare challenges from other regions. These challenges complicate the management and treatment of cleft lip and/or palate, highlighting the need for tailored healthcare strategies to address the specific needs of this population. However, a comprehensive understanding of the patterns and distribution of these deformities in Somalia remains limited. This retrospective cross-sectional study analyzed 2253 clinical records registered in Somalia spanning 2018–2023, obtained from the Bela Risu Foundation, a not-for-profit organization that provides free surgeries for people affected by craniofacial deformities. After meticulous record verification and data extraction, cleft pattern modeling was used to analyze each case. Data were imported to a statistical software package, SPSS, and descriptive statistics were calculated, which included means, frequencies, percentages, and standard deviations. Additionally, comparative analyses between genders were conducted. The findings revealed a significantly higher average presentation age than global findings. We also observed a greater number of males than females in orofacial cleft patients in the data recorded in Somalia that we obtained. Remarkable disparities in case distribution across states within the country were observed. Cleft lip emerged as the most observed primary defect, whereas lip and nose defects subsequent to surgical treatment of primary clefts constituted the most frequent secondary defect. These findings shed light on the unique patterns and distribution of cleft lip and palate deformities in Somalia, highlighting the need for targeted interventions and support systems.</p>\u0000 </div>","PeriodicalId":10626,"journal":{"name":"Congenital Anomalies","volume":"65 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145038287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Integrity Forests Are Critical for Forest Specialist Birds","authors":"Corey T. Callaghan,&nbsp;Ruben Venegas-Li,&nbsp;Brittany M. Mason,&nbsp;Richard A. Fuller,&nbsp;Rebecca Spake,&nbsp;James E. M. Watson","doi":"10.1111/geb.70118","DOIUrl":"https://doi.org/10.1111/geb.70118","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Efforts to retain and restore forest integrity—the degree to which a forest's structure and function are not modified by humans—are increasingly underpinning global biodiversity conservation efforts. However, there is still much uncertainty around how species respond to changes in forest integrity. Geographically variable responses would have consequences for conservation planning assessments and targeted conservation action. Our goal was to quantify the relationship between forest integrity and bird diversity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Location</h3>\u0000 \u0000 <p>Global; 98 bioregions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Time Period</h3>\u0000 \u0000 <p>2017–2020.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Major Taxa Studied</h3>\u0000 \u0000 <p>Birds.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>By integrating global-scale spatially explicit forest landscape integrity data with a citizen science bird dataset, we provide the first empirical assessment of the relationship between forest integrity and bird diversity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We found that both species richness and abundance of forest specialists had a positive association with integrity. However, the relationship between forest integrity and bird diversity varied across bioregions, with bioregions at low latitudes tending to have more positive relationships between forest integrity and species richness. Of the 74 bioregions assessed, 64% had more than half of their species favouring high integrity forests.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Main Conclusions</h3>\u0000 \u0000 <p>These results support calls for the targeted protection of the world's remaining high-integrity forests but also showcase that consideration must be given to restoring forest integrity where possible.</p>\u0000 </section>\u0000 </div>","PeriodicalId":176,"journal":{"name":"Global Ecology and Biogeography","volume":"34 9","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/geb.70118","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145051152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regorafenib as maintenance therapy showed significant delayed progression of non-adipocytic soft tissue sarcomas","authors":"Carrie Printz","doi":"10.3322/caac.70032","DOIUrl":"https://doi.org/10.3322/caac.70032","url":null,"abstract":"&lt;p&gt;Because advanced non-adipocytic soft tissue sarcomas (STSs) are aggressive with poor outcomes, the goal of treatment is to delay progression and ensure quality of life. Doxorubicin (an anthracycline chemotherapy) is first-line standard of care for these patients. Researchers have discussed whether adding maintenance therapy might improve progression-free survival (PFS), but few studies have examined the option.&lt;/p&gt;&lt;p&gt;Non-adipocytic STSs are cancers that start in the body’s connective tissues but not in fat cells (which are called adipocytes).&lt;/p&gt;&lt;p&gt;EREMISS, a double-blind, randomized, controlled, phase 2 trial, evaluated the safety and PFS of maintenance therapy with regorafenib in patients with non-adipocytic STSs. Findings showed that regorafenib significantly increased PFS after first-line treatment by a median difference of 2.1 months. Results were published in the &lt;i&gt;Annals of Oncology&lt;/i&gt; (doi:10.1016/j.annonc.2025.03.024).&lt;/p&gt;&lt;p&gt;“The sarcoma community has had a lot of conversation around the role of maintenance, and I was really pleased to see this well-designed study,” says Lara Davis, MD, an associate professor of medicine in the Division of Hematology/Medical Oncology and the director of the Sarcoma Program at Oregon Health &amp; Science University in Portland. “The findings are clearly significant and look very promising. While the role of maintenance therapy in general is not fully established, it’s absolutely worth additional investigation.”&lt;/p&gt;&lt;p&gt;The EREMISS trial assessed the activity and safety of regorafenib in 126 patients with advanced non-adipocytic STSs who were enrolled in 17 centers in France from May 2019 to November 2022.&lt;/p&gt;&lt;p&gt;Regorafenib is an oral multikinase inhibitor that can target oncogenic pathways. Studies have shown its effectiveness in treating some sarcoma subtypes, aside from liposarcomas.&lt;/p&gt;&lt;p&gt;Female patients represented 55% of the total enrollment, and the median age was 58 years. The most common subtype was leiomyosarcoma (59%).&lt;/p&gt;&lt;p&gt;Participants who had stable disease or a partial response after six cycles of doxorubicin as a first-line treatment received 120 mg of regorafenib per day for 3 weeks on and 1 week off. The primary end point was PFS. It was accessible in 122 patients.&lt;/p&gt;&lt;p&gt;The median PFS by blinded central review was 3.5 months in the placebo arm and 5.6 months in the regorafenib arm. Although overall survival was not the primary end point, it was 20.5 months for the placebo group and 27.6 months for the regorafenib group.&lt;/p&gt;&lt;p&gt;In the placebo arm, 4.8% of the patients experienced grade 3 or higher adverse events, whereas 56.3% of the patients receiving regorafenib did. The most common adverse events were asthenia (9%), atrial hypertension (8%), and rash (8%).&lt;/p&gt;&lt;p&gt;Robin Jones, MD, a medical oncologist and sarcoma specialist at the Royal Marsden Cancer Center in London, praises the study’s design.&lt;/p&gt;&lt;p&gt;“The authors should be congratulated for actually completing and publishing the tria","PeriodicalId":137,"journal":{"name":"CA: A Cancer Journal for Clinicians","volume":"75 5","pages":"368-370"},"PeriodicalIF":232.4,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://acsjournals.onlinelibrary.wiley.com/doi/epdf/10.3322/caac.70032","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145038286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}