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{"title":"Invasive Crayfish: Drivers or Passengers of Degradation in Freshwater Ecosystems?","authors":"Jelle A. Dercksen,&nbsp;Maarten J. J. Schrama,&nbsp;Kevin K. Beentjes,&nbsp;Bob N. Bastiaans,&nbsp;Rody Blom,&nbsp;André van Roon,&nbsp;Peter W. Lindenburg,&nbsp;Krijn B. Trimbos","doi":"10.1002/edn3.70062","DOIUrl":"https://doi.org/10.1002/edn3.70062","url":null,"abstract":"<p>Invasive species, such as the freshwater crayfish <i>Procambarus clarkii</i>, reportedly negatively influence the abundance of various aquatic species. Moreover, these invaders are increasingly linked to ecological degradation of aquatic ecosystems, as invaded habitats show increased levels of turbidity, nitrogen, and organic matter concentration. <i>P. clarkii</i> has, among other impacts, been associated with eutrophication in invaded habitats. However, observations suggest that the presence of <i>P. clarkii</i> is often not accompanied by ecosystem degradation, raising the question of whether they are drivers of degradation or function as passive passengers, with the degradation being caused by other stressors. To investigate these contrasting hypotheses, we conducted a full factorial experiment in 24 mesocosms with <i>P. clarkii</i> and nutrient pollution (specifically N, P, and K), a ubiquitous stressor in aquatic ecosystems. Here, we assessed the effects on community compositions of morphologically identified macrophytes and chironomids, as well as the compositions of bacteria, phytoplankton, and diatoms identified using environmental DNA (eDNA) metabarcoding. Nutrient pollution induced significant shifts in macrophyte biomass and in the composition of the bacterial, diatom, and phytoplankton communities. All microbial communities exposed to nutrient pollution initially diverged from the control, after which the bacterial and phytoplankton communities converged back to the control in the final weeks. In contrast, we found only marginal effects of <i>P. clarkii</i>, rendering it unlikely as a significant short- to medium-term driver of the tested biodiversity. As microbial communities respond quickly to changes in the environmental conditions, these results signify that the mesocosms used in the study were relatively stable in spite of the presence of <i>P. clarkii</i>. The crayfish density and timeframe studied may be leveraged as threshold values in the design and execution of freshwater management strategies that aim to avert potential negative impacts of <i>P. clarkii</i> on ecosystem structure. Ultimately, the importance of nutrient pollution is reinforced as a driver of environmental change in aquatic ecosystems.</p>","PeriodicalId":52828,"journal":{"name":"Environmental DNA","volume":"7 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/edn3.70062","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prosthetic Soft Tissue Management in Esthetic Implant Restorations, Part II: Post-surgical Considerations and Impression Techniques. A Narrative Review","authors":"Faezeh Atri,&nbsp;Kimia Nokar","doi":"10.1002/cre2.70097","DOIUrl":"https://doi.org/10.1002/cre2.70097","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This two-part review article delineates various techniques to enhance esthetic outcomes in anterior implant treatments. Part I concentrates on presurgical measures, case selection, implant placement, and restoration timing. Part II discusses postsurgical steps, the temporary restoration phase, the emergence profile contour, abutment types, and impression techniques.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>A comprehensive search was conducted using Medline/PubMed, Embase, Scopus, and the Cochrane Library. The primary keywords included: “Dental Implants,” “Dental Prosthesis, Implant-Supported,” “Esthetics, Dental,” “Dental Impression Techniques,” and “Tissue Management.”</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Initially, 1472 studies were identified, from which 187 were selected based on publication year and title relevance. After removing duplicates, 84 abstracts were reviewed in full text, culminating in 59 studies being thoroughly analyzed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The decision to deliver an immediate restoration following implant insertion depends on the primary stability. However, in cases where delayed restoration is chosen, it is essential to consider the potential collapse of the soft tissue. A temporary restoration phase could be beneficial to aid in rebuilding the soft tissue. After achieving the desirable level of soft tissue, several techniques are available to achieve a precise transfer of molded gingival architecture, including customized impression coping, injection of soft material around the provisional restoration in the master cast, and digital impression.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70097","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lithobezoar and Phytobezoar Causing Intestinal Obstruction: A Report of Two Cases","authors":"Bishnu Prasad Kandel,&nbsp;Anup Chalise,&nbsp;Sujan Shrestha,&nbsp;Paleswan Joshi Lakhey","doi":"10.1002/ccr3.70293","DOIUrl":"https://doi.org/10.1002/ccr3.70293","url":null,"abstract":"<p>Concretion or mass formed of exogenous undigested material in the gastrointestinal tract is called bezoar. Bezoar is a rare condition and can present with clinical features ranging from recurrent abdominal pain to acute presentation with obstruction or gastrointestinal bleeding. Preoperative diagnosis is usually done by imaging studies. They are treated with endoscopic or surgical removal of the bezoar along with treatment of complications and underlying illness. Here, we present two cases of bezoars: first, a case of a duodenal lithobezoar in 35-year-old male who presented with features of gastric outlet obstruction. He was found to have duodenal stricture and multiple small lithobezoars in the stomach and duodenum. The bezoars were removed by laparotomy and gastrotomy; and gastrojejunostomy was done to bypass the stricture. The second was a jejunal phytobezoar in 42-year-old male who presented with jejunal obstruction. Laparotomy and resection of the involved segment of jejunum and end-to-end anastomosis were done. Both the patients improved without postoperative complications.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 3","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.70293","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Efficient Cluster Based Routing in Wireless Sensor Networks Using Multiobjective-Perturbed Learning and Mutation Strategy Based Artificial Rabbits Optimisation","authors":"Babiyola Arulanandam,&nbsp;Khalid Nazim Abdul Sattar,&nbsp;Rocío Pérez de Prado,&nbsp;Bidare Divakarachar Parameshchari","doi":"10.1049/cmu2.70020","DOIUrl":"https://doi.org/10.1049/cmu2.70020","url":null,"abstract":"<p>Wireless sensor networks (WSNs) is a wireless system including the set of distributed sensor nodes used for physical or environmental observation. A network energy expenditure is considered as a significant concern because of battery restricted sensors of the WSN. Clustering and multi hop routing are considered as effective approaches to enhance the network lifecycle and communication. Achieving the anticipated objective of reducing the energy expenditure, thereby increasing the network lifecycle, is considered as an optimisation issue. In recent times, a nature inspired meta-heuristic approaches are extensively utilised for solving the different optimisation issues. In this context, this research aims to accomplish the objective by proposing the multiobjective-perturbed learning and mutation strategy based artificial rabbits optimisation namely M-PMARO for an optimum cluster head (CH) selection and route discovery. The proposed M-PMARO incorporates an experience based perturbed learning (EPL) and mutation strategy to identify the capable regions over the search space for enhancing the exploration and avoiding the local optima issue. To formulate the multiobjective, the residual energy, average intracluster distance, average base station (BS) distance, CH balancing factor (CHBF) and node centrality are incorporated for optimum CH discovery while the residual energy and average BS distance are considered for multi hop routing. The M-PMARO is analysed based on alive nodes, dead nodes, energy expenditure, throughput and data received in BS and network lifecycle. The viability of M-PMARO is validated by comparing it with existing approaches such as fitness based glowworm swarm with fruitfly algorithm (FGF), energy balanced particle swarm optimisation (EBPSO), improved bat optimisation algorithm (IBOA), graph neural network (GNN) and fuzzy logic and particle swarm optimisation (PSO) based clustering routing protocol namely PFCRE. The alive node count of M-PMARO is 100 for 1200 rounds, which is higher than the EBPSO.</p>","PeriodicalId":55001,"journal":{"name":"IET Communications","volume":"19 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1049/cmu2.70020","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Outcomes With Notch Inhibitors in Notch-Activated Recurrent/Metastatic Adenoid Cystic Carcinoma","authors":"Camilla O. Hoff,&nbsp;Luana G. de Sousa,&nbsp;Flavia Bonini,&nbsp;Eduardo Dal Lago,&nbsp;Kaiwen Wang,&nbsp;Juliana M. Siqueira,&nbsp;Yoshitsugu Mitani,&nbsp;Adel K. El-Naggar,&nbsp;Renata Ferrarotto","doi":"10.1002/cam4.70663","DOIUrl":"https://doi.org/10.1002/cam4.70663","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Adenoid cystic carcinoma (ACC) with NOTCH-activating mutations presents a clinical challenge due to its poor prognosis. NOTCH inhibitors have emerged as a potential therapy for ACC patients with NOTCH activation. This study aimed to evaluate the efficacy of NOTCH inhibitors in this patient population.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A retrospective analysis was conducted on patients with metastatic ACC harboring NOTCH pathway activation, who received NOTCH inhibitors at MD Anderson Cancer Center. NOTCH inhibitors included AL101, a gamma-secretase inhibitor, and brontictuzumab, an antibody targeting NOTCH1. NOTCH pathway activation was assessed through genomic analysis for NOTCH-activating mutations or immunohistochemistry for NOTCH1 intracellular domain (NICD1). Efficacy endpoints included best overall response (BOR) and progression-free survival (PFS) per RECIST or MD Anderson bone response criteria.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Twenty-nine patients were included, with a predominance of solid histology (86%). NOTCH-activating mutations were identified in 82% of patients, and 95% showed positive NICD1 staining. BOR revealed partial response in 17% of patients, stable disease in 55%, and progressive disease in 28%. Median response duration was longer for AL101 compared to brontictuzumab (9.9 vs. 1.7 months, <i>p</i> = 0.04). Median PFS with NOTCH inhibitor was 4.2 months (95% CI 2.7–8.6 months). Progression of nontarget lesions occurred in 34% of patients. Comparison with prior therapy showed longer PFS with NOTCH inhibitors (HR 0.38, 95% CI 0.19–0.78, <i>p</i> = 0.0065).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>NOTCH inhibitors demonstrate activity in NOTCH-activated ACC, surpassing the efficacy of observation or prior systemic therapies. However, limited PFS and progression of nontarget lesions suggest the potential need for combination therapy to address ACC heterogeneity.</p>\u0000 </section>\u0000 </div>","PeriodicalId":139,"journal":{"name":"Cancer Medicine","volume":"14 5","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cam4.70663","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GOLEM: A tool for visualizing the distribution of Gene regulatOry eLEMents within the plant promoters with a focus on male gametophyte","authors":"Lukáš Nevosád,&nbsp;Božena Klodová,&nbsp;Jiří Rudolf,&nbsp;Tomáš Raček,&nbsp;Tereza Přerovská,&nbsp;Alžbeta Kusová,&nbsp;Radka Svobodová,&nbsp;David Honys,&nbsp;Petra Procházková Schrumpfová","doi":"10.1111/tpj.70037","DOIUrl":"https://doi.org/10.1111/tpj.70037","url":null,"abstract":"<p>Gene expression regulation during tissue development is extremely complex. A key mechanism of gene regulation is the recognition of regulatory motifs, also known as cis-regulatory elements (CREs), by various proteins in gene promoter regions. Localization of these motifs near the transcription start site (TSS) or translation start site (ATG) is crucial for transcription initiation and rate. Transcription levels of individual genes, regulated by these motifs, can vary significantly across tissues and developmental stages, especially in processes like sexual reproduction. However, the precise localization and visualization of these motifs in relation to gene expression in specific tissues can be challenging. Here, we introduce a freely available tool called GOLEM (Gene regulatOry eLEMents; https://golem.ncbr.muni.cz), which enables users to precisely locate any motif of interest with respect to TSS or ATG within the relevant plant genomes across the plant Tree of Life (<i>Chara</i>, <i>Marchantia</i>, <i>Physcomitrium</i>, <i>Azolla</i>, <i>Ceratopteris</i>, <i>Amborella</i>, <i>Oryza</i>, <i>Zea</i>, <i>Solanum</i> and <i>Arabidopsis</i>). The visualization of the motifs is performed with respect to the transcript levels of particular genes in leaves and male reproductive tissues and can be compared with genome-wide distribution regardless of the transcription level. Additionally, genes with specific CREs at defined positions and high expression in selected tissues can be exported for further analysis. GOLEM's functionality is illustrated by its application to conserved motifs (e.g. TATA-box, ABRE, I-box, and TC-element), hormone-responsive elements (GCC-box, ARR10_binding motif), as well as to male gametophyte-related motifs (e.g., LAT52, MEF2, and DOF_core).</p>","PeriodicalId":233,"journal":{"name":"The Plant Journal","volume":"121 5","pages":""},"PeriodicalIF":6.2,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/tpj.70037","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Type VI Secretion System of Sinorhizobium fredii USDA257 Is Required for Successful Nodulation With Glycine max cv Pekin","authors":"Pedro José Reyes-Pérez,&nbsp;Irene Jiménez-Guerrero,&nbsp;Ana Sánchez-Reina,&nbsp;Cristina Civantos,&nbsp;Natalia Moreno-de Castro,&nbsp;Francisco Javier Ollero,&nbsp;Jacinto Gandullo,&nbsp;Patricia Bernal,&nbsp;Francisco Pérez-Montaño","doi":"10.1111/1751-7915.70112","DOIUrl":"https://doi.org/10.1111/1751-7915.70112","url":null,"abstract":"<p>The symbiotic relationship between rhizobia and legumes is critical for sustainable agriculture and has important economic and environmental implications. In this intricate process, rhizobial bacteria colonise plant roots and induce the formation of specialised plant organs, the nodules. Within these structures, rhizobia fix environmental nitrogen into ammonia, significantly reducing the demand for synthetic fertilisers. Multiple bacterial secretion systems (TXSS, Type X Secretion System) are involved in establishing this symbiosis, with T3SS being the most studied. While the Type 6 Secretion System (T6SS) is known as a “nanoweapon” commonly used by diderm (formerly gram-negative) bacteria for inter-bacterial competition and potentially manipulating eukaryotic cells, its precise role in legume symbiosis remains unclear. <i>Sinorhizobium fredii</i> USDA257, a fast-growing rhizobial strain capable of nodulating diverse legume plants, possesses a single T6SS cluster containing genes encoding structural components and potential effectors that could target plant cells and/or act as effector-immunity pairs. Our research reveals that this T6SS can be induced in nutrient-limited conditions and, more importantly, is essential for successful nodulation and competitive colonisation of <i>Glycine max</i> cv Pekin. Although the system did not demonstrate effectiveness in eliminating competing bacteria in vitro, its active presence within root nodules suggests a sophisticated role in symbiotic interactions that extends beyond traditional interbacterial competition.</p>","PeriodicalId":209,"journal":{"name":"Microbial Biotechnology","volume":"18 3","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1751-7915.70112","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tropical Niche Conservatism and Dispersal Limitation Jointly Determine Taxonomic and Phylogenetic β-Diversities of Odonata in Eastern China","authors":"Zhenyuan Liu,&nbsp;Bo-Ping Han,&nbsp;Janne Soininen","doi":"10.1111/geb.70018","DOIUrl":"https://doi.org/10.1111/geb.70018","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Aim&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Tropical niche conservatism (TNC) and dispersal limitation (DL) are major ecological and evolutionary mechanisms in shaping taxonomic and phylogenetic β-diversities. While these mechanisms have been studied in plants and vertebrates, their roles in freshwater taxa remain unclear. We leveraged Odonata species distribution and phylogenetic data to map geographical patterns of taxonomic and phylogenetic β-diversities, and to determine whether Odonata β-diversity is primarily shaped by TNC or DL and whether temperature seasonality is a key driver determining TNC.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Location&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Eastern China.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Time Period&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Present.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Major Taxa Studied&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Odonata.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A moving window containing nine grids of 50 × 50 km was employed to quantify taxonomic and phylogenetic β-diversities, including their turnover and nestedness components. A null model was utilised to calculate randomly expected phylogenetic β-diversity based on observed taxonomic β-diversity and site-specific regional species pools. The generalised dissimilarity model was used to assess the roles of climatic and geographic distances shaping β-diversity and to identify the key climatic factors.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Taxonomic total β-diversity and its turnover component were generally higher than phylogenetic β-diversity in most Odonata communities, with phylogenetic β-diversity being relatively higher mainly in tropical regions. Current climatic factors independently explained slightly more of the variation in total β-diversity than geographic distance alone, while geographic distance independently explained slightly greater proportions of deviance in turnover components. However, their joint effects accounted for an even larger part of the variation in β-diversity. The key climatic predictors were temperature seasonality.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Main Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Current climatic factors, particularly temperature seasonality, largely shape taxonomic and phylogenetic β-diversities of Odonata communities. Spatial turnover along the climatic gradient tends to involve phylogenetically related taxa, resulting in overall higher taxonomic than phylogenetic β-diversity, supporting the TNC. The joint effects of climatic and geographic distances hig","PeriodicalId":176,"journal":{"name":"Global Ecology and Biogeography","volume":"34 3","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radium levels in Brazil nuts: A review of the literature.","authors":"Christian Koeder, Markus Keller","doi":"10.1111/nbu.12717","DOIUrl":"10.1111/nbu.12717","url":null,"abstract":"<p><p>Brazil nuts are well known for their extraordinarily high selenium content. For this reason, they are frequently recommended as a kind of natural selenium 'supplement', particularly for certain population groups such as vegetarians and vegans in regions with low soil selenium levels. Typically, an intake of one or two Brazil nuts per day is recommended. Brazil nuts, however, also stand out from other nuts in terms of their high (albeit highly variable) radium content. The radium isotopes Ra-226 and Ra-228 emit alpha- and beta-radiation, with this type of radiation being particularly harmful when ingested. Consequently, it is important to consider radium levels in Brazil nuts before formulating recommendations for a long-term, daily intake of these nuts. To date, however, no comprehensive overview of radium levels in Brazil nuts has been published. Therefore, a literature review without time or language restrictions was conducted, including unpublished original data from Germany. The literature review (including the German data) indicated mean Ra-226 and Ra-228 levels of 49 (range: 17-205) mBq/g and 67 (range: 12-235) mBq/g, respectively. Assuming a consistent daily intake of one or two Brazil nuts, this would result in an effective dose of ~88-220 μSv/year. This level of exposure appears to be neither clearly harmful nor clearly harmless. As increased radioactivity exposure (at least at higher doses) is associated with increased cancer risk, randomised controlled trials assessing the effect of Brazil nuts on cancer risk biomarkers are needed.</p>","PeriodicalId":48536,"journal":{"name":"Nutrition Bulletin","volume":" ","pages":"1-11"},"PeriodicalIF":2.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11815606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary fats and cardiometabolic health-from public health to personalised nutrition: 'One for all' and 'all for one'.","authors":"Julie Anne Lovegrove","doi":"10.1111/nbu.12722","DOIUrl":"10.1111/nbu.12722","url":null,"abstract":"<p><p>This paper provides a summary of the 2023 British Nutrition Foundation Annual Lecture by Professor Julie Lovegrove. Professor Lovegrove is the head of the Hugh Sinclair Unit of Human Nutrition at the University of Reading. Professor Lovegrove, who was nominated for the BNF Prize for her outstanding contribution to nutritional sciences has published over 300 scientific papers and made a major contribution to establishing the relevance of dietary fat quality in the development and prevention of cardiometabolic disease.</p>","PeriodicalId":48536,"journal":{"name":"Nutrition Bulletin","volume":" ","pages":"132-141"},"PeriodicalIF":2.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11815623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}