Wiley最新文献

{"title":"Climate Change, Fisheries Management, and Increases in Demersal Fish Distribution in a Southern Ocean Biodiversity Hotspot","authors":"Joel Williams,&nbsp;Scott Foster,&nbsp;Skip Woolley,&nbsp;Philippe Ziegler,&nbsp;Cara Masere,&nbsp;Kaitlin Naughten,&nbsp;Otso Ovaskainen,&nbsp;Craig Johnson,&nbsp;Nicole Hill","doi":"10.1111/gcb.70549","DOIUrl":"https://doi.org/10.1111/gcb.70549","url":null,"abstract":"<div>\u0000 \u0000 <p>The world's oceans and their biodiversity are undergoing change driven by climate change and anthropogenic impacts such as fishing. The Kerguelen Plateau is a biodiversity hotspot with many endemic fish species; furthermore, the region has economic importance in supporting valuable fisheries. This region is also a climate change hotspot with known notable changes in the location of the polar front, ocean currents, and primary productivity. In this study, we use data from long-term scientific trawl surveys and contemporary joint species distribution models to understand how the demersal fish assemblage of the Kerguelen Plateau has changed through time and space. The modelling indicates that most demersal species have had notable changes in their occurrence and CPUE from 2003 to 2016. This included a significant increase in species richness throughout the study period. The modelling also provides novel insights into the depth, climatic, and environmental preferences for all species, including many species that were previously data-limited. It is unclear whether these changes reflect shifts in the fishery management or the effects of climate change, but most likely a combination of all. We also found evidence of several species' distributions responding to temperature variability, with species being exposed to the ongoing impacts of climate change. These findings will be used by managers and policy makers to inform climate change risk assessments, supporting future-decision making to ensure the continuation of sustainable fisheries and the protection of biodiversity.</p>\u0000 </div>","PeriodicalId":175,"journal":{"name":"Global Change Biology","volume":"31 10","pages":""},"PeriodicalIF":12.0,"publicationDate":"2025-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145317616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issue Information: Laser & Photon. Rev. 19(20)/2025","authors":"","doi":"10.1002/lpor.70449","DOIUrl":"https://doi.org/10.1002/lpor.70449","url":null,"abstract":"","PeriodicalId":204,"journal":{"name":"Laser & Photonics Reviews","volume":"19 20","pages":""},"PeriodicalIF":10.0,"publicationDate":"2025-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lpor.70449","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145317797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BCL-2 inhibition in Waldenström macroglobulinaemia and marginal zone lymphoma.","authors":"Shayna Sarosiek, Uriel Suarez, Maria Fernandez-Turizo, Kristopher A Sarosiek, Jorge J Castillo","doi":"10.1111/bjh.70208","DOIUrl":"https://doi.org/10.1111/bjh.70208","url":null,"abstract":"<p><p>Marginal zone lymphoma (MZL) and Waldenström macroglobulinaemia (WM) are B-cell lymphomas characterized by an indolent disease course. However, both are incurable with current standard treatments. Therefore, additional therapies are certainly needed. BCL-2 inhibition has been a welcome addition to the treatment armamentarium for haematological malignancies. The BCL-2 inhibitor venetoclax is approved by the Food and Drug Administration and the European Medicines Agency for the treatment of chronic lymphocytic leukaemia and acute myeloid leukaemia and is endorsed by the National Comprehensive Cancer Network for the treatment of WM and mantle cell lymphoma. In this review, we provide an overview of the current understanding of the BCL-2 apoptotic pathway and its impact on the development and maintenance of haematological cancers. We also summarize the preclinical and ongoing clinical experience with BCL-2 inhibitors, such as venetoclax, sonrotoclax, lisaftoclax and LOXO-338. BCL-2 inhibitors have emerged as safe and effective treatment options for treating patients with MZL and WM.</p>","PeriodicalId":135,"journal":{"name":"British Journal of Haematology","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145327845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and glycaemic control during exercise with the MiniMed™ 780G: A narrative review of evidence from lab to real world.","authors":"Jeremy Basset-Sagarminaga, Christophe De Block, Kirsten Nørgaard, David Norman O'Neal, Tim Van den Heuvel, Julie Taplin, Vittorino Smaniotto, Ohad Cohen","doi":"10.1111/dom.70211","DOIUrl":"https://doi.org/10.1111/dom.70211","url":null,"abstract":"<p><p>Physical activity plays a critical role in reducing cardiovascular risk among individuals with type 1 diabetes (PwT1D); however, more than two-thirds of PwT1D remain insufficiently active, primarily due to the unpredictability of glucose fluctuations and the fear of hypoglycaemia during exercise. Automated insulin delivery systems, such as the MiniMed™ 780G (MM780G), offer potential solutions by automating insulin dosing, supporting stable glucose control, and allowing for a higher temporary glucose target. This narrative review summarizes the current evidence on the safety and efficacy of the MM780G system during exercise in PwT1D, with a focus on the temporary target (TT) feature and real-world usability. The MM780G consistently supports glycaemic safety during exercise, especially moderate-intensity aerobic activity, with time in range frequently meeting or exceeding consensus guidelines. Activation of the TT feature 60- to 120-min pre-exercise, particularly when paired with reduced meal boluses, significantly lowers the risk of hypoglycaemia. Real-world studies confirm its safety across varied activities, including prolonged aerobic exercise and contact sports. While evidence for resistance and high-intensity exercise remains limited, initial findings are favourable. User education is crucial to optimize use, particularly in competitive and prolonged settings. The MM780G is a safe and effective tool for glycaemic management during exercise in PwT1D. Best outcomes are achieved through strategic use of the TT feature and meal bolus reduction, individualized carbohydrate strategies and proper education. Applying easy-to-follow pre-exercising recommendations may encourage better engagement with regular exercising. Further research is needed on long-term adaptations to training and resistance-based exercise protocols.</p>","PeriodicalId":158,"journal":{"name":"Diabetes, Obesity & Metabolism","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145327855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hard-Wired Solid-State Bioelectronic Micropore Devices: Permanent Metal-Protein-Metal Junction Proof-of-Concept.","authors":"Sudipta Bera, Eran Mishuk, Ping'an Li, Sourav Das, Sigal Keshet, Sharon Garusi, Leonid Tunik, Eran Edri, Yoram Selzer, Israel Pecht, Ayelet Vilan, Mordechai Sheves, David Cahen","doi":"10.1002/smll.202506560","DOIUrl":"https://doi.org/10.1002/smll.202506560","url":null,"abstract":"<p><p>The design, fabrication, and application of robust metal/protein/metal junctions are presented with ultrathin (≈20 nm) protein films demonstrating long-term stability in ambient conditions and preserving their electron transport behavior also at ≈10 K. These junctions establish a reliable platform with a permanent contact configuration, where the confined protein layer retains its functional activity after metal contact evaporation on the protein. A bottom-up micropore device (MpD) fabrication strategy is used and optimized to ensure reproducibility. The sub-nanometer roughness of the bottom electrode is preserved within the micropore, enabling uniform protein layer deposition and film formation. In the MpD structures, protein layers are integrated between Au-covered substrates and an e-beam evaporated Pd contacts. Depositing multi-layered protein films allows for defining film widths, as tested by the atomic force microscopy (AFM)-based scratching technique. The films are composed of human serum albumin (HSA) and bacteriorhodopsin (bR). Pd's preferred 2D growth minimized metal penetration and short circuits. Impedance phase response analysis shows that ≈60% of the junctions are functional ones, demonstrating the effectiveness of the fabrication approach. These protein-based MpD junctions provide a basis for future stable platforms for electron transport studies of bio- and other soft materials.</p>","PeriodicalId":228,"journal":{"name":"Small","volume":" ","pages":"e06560"},"PeriodicalIF":12.1,"publicationDate":"2025-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145327881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the Folding Dynamics of DNA Origami Structures.","authors":"Meysam Mohammadi-Zerankeshi, James Houston, Ogochukwu K U Elisha-Wigwe, Abi Sachi, Alexander E Marras","doi":"10.1002/smll.202504855","DOIUrl":"https://doi.org/10.1002/smll.202504855","url":null,"abstract":"<p><p>Achieving high folding yield remains a challenge in DNA origami, particularly as structures increase in complexity and scale. Here, how DNA origami design influences folding is investigated using a combination of real-time fluorometry, gel electrophoresis, electron microscopy, and theoretical analysis. Results reveal a balance of free energy changes from loop formation and hybridization that govern nucleation of nanostructure assembly, while the extent of cooperativity determines the overall assembly. The effect of structural complexity, staple design, and scaffold design on each energetic parameter, folding yield, kinetics, and cooperativity is measured. The results show that the scaffold pattern determines the extent of cooperativity, where fewer scaffold crossovers result in more cooperative folding. These findings use a tool developed in this work to estimate the extent of cooperativity in any structure. It is also found that limiting the number of crossovers per staple should be prioritized over extending staple binding domains, as the entropic penalty dominates the favorable binding. Finally, a 1-2 h focused annealing ramp strategy is demonstrated, that can increase yield up to 17% relative to traditional multi-day ramps. Optimizing energy changes and cooperativity through design can significantly enhance assembly yield and reduce time, particularly for complex structures, aiding large-scale DNA materials.</p>","PeriodicalId":228,"journal":{"name":"Small","volume":" ","pages":"e04855"},"PeriodicalIF":12.1,"publicationDate":"2025-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145328031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conductive Thermoplastic Polyurethane Composites with Multicarbon Fillers for Flexible Resistive Strain Sensors for Handwriting Recognition","authors":"Zhiyuan Li,&nbsp;Yeju Ma,&nbsp;Jiayu Guo,&nbsp;Xiazhen Yang,&nbsp;Bing Guo,&nbsp;Hangyan Shen","doi":"10.1002/slct.202504337","DOIUrl":"https://doi.org/10.1002/slct.202504337","url":null,"abstract":"<p>With the rapid development of portable electronic devices, smart wearable technology shows great potential in the fields of personalized motion tracking, health monitoring, and human-computer interaction. However, the complex preparation processes and stringent performance requirements pose challenges to the widespread applications of these technologies. To address this issue, we propose a straightforward and economical method for the preparation of flexible resistive strain sensors using thermoplastic polyurethane porous films. By a nonsolvent induced phase separation method, we prepared porous films incorporating varying ratios of carbon black (CB)/graphene and CB/carbon nanofibers to serve as conductive strain-sensitive layers for the strain sensors. This simple and efficient preparation method not only reduces the production cost but also improves the manufacturability and performance stability of the sensors, thereby providing important support for the future development of intelligent technologies. The resulting flexible resistive strain sensors exhibit excellent sensing performance, characterized by a maximum strain gauge factor of 9.822, a wide tensile range (<i>ε</i> = 0% to 30%), and commendable cyclic tensile reliability. The application results indicate that these strain sensors excel in the handwriting recognition classification task, establishing a solid foundation for diverse sensor technology applications in the fields of smart health monitoring and virtual reality interaction.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 39","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145317549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-Co-Solvent Electrolyte Engineering for Robust Aqueous Zinc Metal Batteries at 60 °C.","authors":"Siying Wang, Lingjie Long, Lilin Chen, Yixian Xing, Qiangwei Li, Leqing Deng, Lidong Wang","doi":"10.1002/smtd.202501572","DOIUrl":"https://doi.org/10.1002/smtd.202501572","url":null,"abstract":"<p><p>Aqueous zinc metal batteries (AZMBs) with intrinsic high safety are a promising candidate for large-scale energy storage at high temperatures. However, the aggravated water-related side reactions (Zn corrosion, hydrogen evolution, etc.) at elevated temperatures enormously impair the reversibility and cycling stability of AZMBs. Herein, the dual co-solvents, triethyl phosphate and γ-valerolactone, are introduced into the aqueous electrolyte to prepare a hybrid electrolyte for high-temperature AZMBs. Besides the flame resistance, this hybrid electrolyte ensures a highly stable and reversible Zn anode at the high temperature of 60 °C, originating from the remarkably suppressed water reactivity and uniform Zn deposition without dendrites. Consequently, using this hybrid electrolyte and testing at the high temperature of 60 °C, the asymmetric Zn||Cu cell provides an average coulombic efficiency as high as 99.4% over 415 cycles, and the symmetric Zn||Zn cell offers a remarkably long cycle life (1354 h) at 0.5 mA cm^-2 and 0.5 mAh cm^-2. Furthermore, the assembled full cell achieves a decent cycling stability (77.6% capacity retention after 550 cycles) concomitant with an unprecedented duration of 910 h at 60 °C. This work offers new insight into electrolyte engineering strategy for high-performance AZMBs at high temperatures.</p>","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e01572"},"PeriodicalIF":9.1,"publicationDate":"2025-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145311970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Insights into Doxorubicin-Human Serum Albumin Interactions: Binding Sites, Conformational Changes, and Pharmacokinetic Implications","authors":"Parisa Nasehi Najafabadi,&nbsp;Mohanmmad Hossein Abnosi,&nbsp;Javad Sargolzaei","doi":"10.1002/slct.202503033","DOIUrl":"https://doi.org/10.1002/slct.202503033","url":null,"abstract":"<p>Doxorubicin, a potent antineoplastic agent, is widely utilized in the treatment of various malignancies, including breast cancer, malignant lymphomas, and soft tissue sarcomas. This study investigates the interaction between doxorubicin and human serum albumin (HSA) under physiological conditions using a combination of biophysical techniques, including circular dichroism (CD), Fourier-transform infrared spectroscopy (FT-IR), equilibrium dialysis, molecular docking, and UV–visible (vis) absorption spectroscopy. The results indicate that doxorubicin quenches the intrinsic fluorescence of HSA via a static quenching mechanism. Binding constants (<i>K</i>_b), Stern–Volmer quenching constants (<i>K</i>_sv), the number of binding sites (<i>n</i>), and thermodynamic parameters were determined at multiple temperatures. Data analysis revealed cooperative binding, wherein the binding of one doxorubicin molecule enhances the affinity for subsequent molecules. Molecular docking studies further demonstrated that doxorubicin interacts primarily with the IIA, IIIA, and IIB subdomains of HSA, inducing subtle conformational changes. Both fluorescence spectroscopy and molecular docking analyses suggest that hydrophobic interactions are a dominant force in the doxorubicin-HSA binding process.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 39","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145317550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prostate-specific membrane antigen positron emission tomography/computed tomography imaging as a precision diagnostic at prostate cancer recurrence after radical prostatectomy: Modeling long-term survival","authors":"Kemal Caglar Gogebakan PhD,&nbsp;Zizi Elsisi MS,&nbsp;Felipe Montano-Campos MS,&nbsp;Lukas Owens BA,&nbsp;Yibai Zhao PhD,&nbsp;Roman Gulati MS,&nbsp;Justin Ferdinandus MD,&nbsp;Wolfgang P. Fendler MD,&nbsp;Jeremie Calais MD, PhD,&nbsp;Thomas A. Hope MD,&nbsp;Sigrid Carlsson MD, PhD, MPH,&nbsp;Jonathan Fainberg MD, MPH,&nbsp;Vincent Laudone MD,&nbsp;Natalia Kunst PhD,&nbsp;Alejandro Berlin MD,&nbsp;Matthew Schipper PhD,&nbsp;Andrew Barbour MD, PhD,&nbsp;Amir Iravani MD,&nbsp;Ruth Etzioni PhD","doi":"10.1002/cncr.70131","DOIUrl":"https://doi.org/10.1002/cncr.70131","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA-PET/CT) is affecting the management of patients with prostate cancer with biochemical recurrence after radical prostatectomy. The long-term outcomes of tailoring salvage treatment on the basis of PSMA-PET/CT status remain to be determined.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A decision-analytic model was developed to project incremental life-years of strategies that allocate treatments at biochemical recurrence after radical prostatectomy on the basis of PSMA-PET/CT status (PSMA-metastatic vs. PSMA-nonmetastatic). Modeled treatments are local/regional (radiation) or systemic (hormone therapy and doublet therapy), administered immediately or delayed. PSMA-metastatic status was assumed to lead to treatment intensification, whereas PSMA-nonmetastatic status would lead to deintensification. To project survival, data on progression to metastasis from a clinical cohort were combined with registry data on postmetastasis survival. Because of the lack of data on long-term treatment benefits by PSMA status, survival was projected by varying the hazard ratio (HR) for disease-specific death among PSMA-metastatic versus PSMA-nonmetastatic patients under delayed or local/regional regimens (HR1) and under immediate systemic regimens (HR2).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Mean life-years are projected to be 15.5 under the non–PSMA-tailored strategy, and mean incremental life-years range from 0.38 to 0.81 depending on HR1 and HR2. A greater benefit is projected when PSMA-metastatic status is more adverse under salvage regimens that do not include systemic agents.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This decision-analytic modeling study projects that PSMA-PET/CT–guided management at biochemical recurrence after radical prostatectomy yields a modest survival benefit under the specified model inputs and assumptions regarding treatment distributions. These findings may complement emerging data on the corresponding economic costs and health-related quality of life.</p>\u0000 </section>\u0000 </div>","PeriodicalId":138,"journal":{"name":"Cancer","volume":"131 21","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145317559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}