Wiley最新文献

{"title":"Homogeneous \"Hard-Soft\" Biphasic Bone Adhesives Promote Comminuted Fracture Healing through Interfacial Adaptation and Mechanical Property Maintenance.","authors":"Chuanwei Zhou, Chenyu Liu, Dongyong Sha, Lili Sun, Changsheng Liu, Yuan Yuan","doi":"10.1002/adma.202502598","DOIUrl":"https://doi.org/10.1002/adma.202502598","url":null,"abstract":"<p><p>Bone adhesives provide remarkable clinical solutions in treating highly comminuted fractures that are difficult to perform surgery with metal fixation. However, no commercial bone adhesives exhibit high adhesion, strength, and osteogenic activity for instant and sustainable fixation in dynamic, wet humoral environments at weight-bearing sites. Here, phase engineering is employed to construct a homogeneous hard-soft biphasic bone adhesive (HB-PTN) with a sea urchin-inspired structure of phosphorylated polyglutamic acid (P-PGA) encapsulating tetracalcium phosphate (TTCP) (hard phase) and a viscoelastic hydrogel composed of amino-functionalized PEGylated poly (glycerol sebacate) (PEGS-NH₂) and P-PGA (soft phases) for immediate, stable fixation. The adhesion and strength of the HB-PTN hydrogel can be tuned by modulating the soft phase/hard phase ratio. The PTN-2 hydrogel exhibited an adhesive strength of ≈280 kPa, a compressive modulus of ≈1.02 MPa, and high fatigue resistance (92%). Moreover, the PTN-2 hydrogel showed limited swelling (130%) and maintained mechanical properties (102%) after immersion in simulated human body fluid. Furthermore, this strategy avoids the agglomeration of inorganic particles and the formation of cracks due to stress concentration observed with traditional mixing methods. In vivo, the PTN adhesives reveal durable and stable adhesion and accelerate fracture healing, demonstrating great clinical potential in comminuted fracture repair.</p>","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":" ","pages":"e2502598"},"PeriodicalIF":27.4,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144281769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On-the-Fly Synthesis of Freestanding Spin-Crossover Architectures With Tunable Magnetic Properties.","authors":"Anh Tuan Ngo, David Aguilà, João Pedro Vale, Semih Sevim, Michele Mattera, Jordi Díaz-Marcos, Ramon Pons, Guillem Aromí, Bumjin Jang, Salvador Pané, Tiago Sotto Mayor, Mario Palacios-Corella, Josep Puigmartí-Luis","doi":"10.1002/adma.202420492","DOIUrl":"https://doi.org/10.1002/adma.202420492","url":null,"abstract":"<p><p>Spin-crossover (SCO) molecular-based switches have shown promise across a range of applications since their discovery, including sensing, information storage, actuators, and displays. Yet limited processability remains a barrier to their real-world implementation, as traditional methods for integrating SCO materials into polymer matrices are often complex, expensive, and prone to producing uneven material distributions. Herein, we demonstrate how 3D flow-focusing chemistry enables unprecedented control for the direct fabrication of SCO composite materials, addressing key challenges in processability, scalability, and cost. By using a 3D coaxial flow-focusing microfluidic device, we simultaneously synthesize [Fe(Htrz)₂(trz)](BF₄) and achieve its homogeneous incorporation into alginate fibers in a continuous manner. The device's versatility allows for precise manipulation of the reaction-diffusion (RD) zone, resulting in SCO composite fibers with tunable physicochemical and magnetic properties. Additionally, we demonstrate the ability to isolate these fibers as freestanding architectures and highlight the potential for printing them with defined shapes. Finally, we show that the 3D control of the RD zone granted by continuous flow microfluidic devices offers precise spatiotemporal control over the distribution of SCO complexes within the fibers, effectively encoding SCO materials into them. SCO-encoded fibers can seamlessly combine adaptability and functionality, offering innovative solutions for application-specific customization.</p>","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":" ","pages":"e2420492"},"PeriodicalIF":27.4,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144281771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unlocking NIR-II Photoluminescence in 2D Copper Tetrasilicate Nanosheets through Flame Spray Synthesis.","authors":"Robert Nißler, Quanyu Zhou, Björn Hill, Sabrina L J Thomä, Lukas R H Gerken, Aurelio Borzi, Kevin Roost, Benjamin Mächler, Xosé Luís Deán-Ben, Antonia Neels, Sebastian Kruss, Daniel Razansky, Inge K Herrmann","doi":"10.1002/adma.202503159","DOIUrl":"https://doi.org/10.1002/adma.202503159","url":null,"abstract":"<p><p>Expanding fluorescence bioimaging into the second near-infrared spectrum (NIR-II, 1000-1700 nm) unlocks advanced possibilities for diagnostics and therapeutics, offering superior tissue penetration and resolution. 2D copper tetrasilicate (CTS) pigments (MCuSi₄O₁₀, M = Ca, Sr, Ba) are known for their brightness and stability, yet synthetic challenges have curbed their integration into bioimaging. Here, flame-spray-pyrolysis (FSP) is introduced as a versatile and scalable synthesis approach to produce ultra-bright, metastable CTS nanosheets (NS) by annealing multi-element metal oxide nanoparticles into 2D crystals through calcination or laser irradiation. Group-II ion incorporation shifts emission into the NIR-II range, with Ba_0.33Sr_0.33Ca_0.33CuSi₄O₁₀ peaking at 1007 nm, while minor Mg-doping induces a hypsochromic shift and extends fluorescence lifetimes. The engineered CTS achieves quantum yields of up to 34%, supporting NS high-frame-rate imaging (> 200 fps). These unique properties enable CTS-NS to serve as powerful contrast agents for super-resolution NIR bioimaging, demonstrated in vivo through transcranial microcirculation mapping and macrophage tracking in mice using diffuse optical localization imaging (DOLI). This pioneering synthesis strategy unlocks wavelength-tunable NS for advanced NIR-II bioimaging applications.</p>","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":" ","pages":"e2503159"},"PeriodicalIF":27.4,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144281776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imeglimin improves hyperglycemia and hypoglycemia-induced cell death and mitochondrial dysfunction in immortalized adult mouse Schwann IMS32 cells.","authors":"Ayako Kato, Wataru Nihei, Hideji Yako, Yasuaki Tatsumi, Tatsuhito Himeno, Masaki Kondo, Yoshiro Kato, Jiro Nakamura, Hideki Kamiya, Kazunori Sango, Koichi Kato","doi":"10.1111/jdi.70092","DOIUrl":"https://doi.org/10.1111/jdi.70092","url":null,"abstract":"<p><strong>Aims/introduction: </strong>Imeglimin, a novel oral antidiabetic drug, enhances glucose-stimulated insulin secretion, improves insulin sensitivity, and reduces mitochondrial reactive oxygen species (ROS) generation. Diabetic neuropathy is driven by oxidative stress caused by hyperglycemia, with mitochondrial ROS overproduction playing a central role. Hypoglycemia also contributes to oxidative stress. This study evaluates the effects of imeglimin on Schwann cells under high- and low-glucose conditions.</p><p><strong>Materials and methods: </strong>We used IMS32 cells, an immortalized mouse Schwann cell line, to investigate cell survival and mitochondrial function under normal, high-, and low-glucose conditions. Assessments included mitochondrial oxidative stress, cytochrome c release, mitochondrial membrane potential, oxygen consumption rate (OCR), Complex I activity, and ATP synthesis.</p><p><strong>Results: </strong>High- and low-glucose conditions caused cell death, elevated mitochondrial ROS, triggered cytochrome c release, disrupted mitochondrial membrane potential, and increased OCR and Complex I activity, while suppressing ATP synthesis. Imeglimin treatment mitigated cell death, reduced oxidative stress, restored mitochondrial membrane potential, normalized OCR and Complex I activity, and improved ATP synthesis under both glucose conditions.</p><p><strong>Conclusions: </strong>Fluctuations in glucose levels impair mitochondrial function in Schwann cells, contributing to peripheral nerve damage in diabetic neuropathy. Imeglimin demonstrated protective effects by alleviating mitochondrial dysfunction and preventing apoptosis signaling. These findings suggest the potential application of imeglimin in preventing and treating diabetic neuropathy; however, the clinical implications require further investigation.</p>","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144281825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Switching From Active Vitamin d and Phosphate Supplementation to Burosumab Significantly Corrects Lower Limb Malalignment in Pediatric X-Linked Hypophosphatemia.","authors":"Leanne M Ward, Erik A Imel, David Frumberg, Lisa Dilworth, Catherine Siener, Zunqiu Chen, Stanley Krolczyk, Thomas O Carpenter","doi":"10.1093/jbmr/zjaf079","DOIUrl":"https://doi.org/10.1093/jbmr/zjaf079","url":null,"abstract":"<p><p>X-linked hypophosphatemia (XLH) is a rare disorder of renal phosphate wasting and dysregulated active vitamin D metabolism, ultimately presenting as rickets and osteomalacia, among other manifestations. Lower extremity deformity (genu valgum and/or varum) is frequent in this pediatric population. Despite prompt active vitamin D and phosphate supplementation (active D/Pi), many patients require corrective surgery for lower limb malformation. Burosumab has demonstrated improvements in lower limb malalignment in children with XLH in several studies. We expand on those reports by assessing mechanical femoral tibial angle (mFTA) change in patients enrolled in the XLH Disease Monitoring Program (DMP), (NCT03651505) to determine the impact of initiating burosumab treatment after a history of active D/Pi. Included patients had either switched from active D/Pi to burosumab treatment at the discretion of their treating physician or as part of a burosumab clinical trial, or remained on active D/Pi through Year 3 of the DMP. Year 3 radiographs were compared with baseline to assess mFTA change and gauge improvement. Additional multivariate factor analysis examined 24 attributes to determine which had the greatest association with mFTA change. Change in mFTA was assessed for each limb independently. A greater proportion of limbs of patients switching from active D/Pi to burosumab had improved mFTA compared with those remaining on active D/Pi (p < .023). Odds ratios comparing limbs that improved to those that did not showed that switching to burosumab yields a significantly greater chance of improvement than continuing active D/Pi (OR [95% CI]: 4.38 [1.09-17.50]; p = .0469). Factor analysis identified younger age at burosumab initiation (p = .001) and lower baseline height Z-score (p = .006) as being significantly associated with greater change in mFTA Z-score. This study shows that switching to burosumab significantly improves lower limb malalignment in children with XLH over benefits conferred by active D/Pi, with early burosumab initiation providing the greatest benefit.</p>","PeriodicalId":185,"journal":{"name":"Journal of Bone and Mineral Research","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144281824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bi-peaked R wave in HRV: A technical pitfall or ventricular pathology","authors":"Anish Singhal MD,&nbsp;Billa Anala MD resident,&nbsp;Madhuri Taranikanti MD,&nbsp;Nitin Ashok John MD,&nbsp;Naveen Ravi MD","doi":"10.1002/joa3.70111","DOIUrl":"https://doi.org/10.1002/joa3.70111","url":null,"abstract":"<p>During routine heart rate variability recording in an elderly male, bi-peaked R waves were recorded consistently. Initially, it was thought to be because of technical issues, which were ruled out systematically; next, it was believed to have been caused by cardiac pathology, which was evaluated using ECG and echocardiography.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":15174,"journal":{"name":"Journal of Arrhythmia","volume":"41 3","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/joa3.70111","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a Hydrophobic Ni0.5Mn0.5Co2O4 Catalyst for Mitigating Moisture-Induced Degradation in Li-Air Batteries","authors":"Nan Wang,&nbsp;Jincheng Ji,&nbsp;Lingling Tang,&nbsp;Xuecheng Cao,&nbsp;Wei Tong","doi":"10.1002/slct.202500509","DOIUrl":"https://doi.org/10.1002/slct.202500509","url":null,"abstract":"<p>Lithium-air (Li-air) batteries are a promising candidate for next-generation energy storage technology. However, their practical development is limited by cathode channel clogging and moisture induced degradation. In this work, a Ni_0.5Mn_0.5Co₂O₄-loaded 3D sodium alginate gel was synthesized as an efficient catalyst for Li-air batteries. To further enhance its performance, a hydrophobic treatment was applied to the catalyst, which significantly reduced the formation of by-products and the lifespan of the Li-air battery in humid atmospheres was extended. At a current density of 500 mA g⁻¹, the modified Li-air batteries demonstrated remarkable cycle stability, achieving 142 cycles in pure oxygen, 91 cycles in ambient air (∼40% relative humidity, RH), and 58 cycles in humid oxygen (∼55% RH, threefold increase compared to unmodified cells). Additionally, the discharge cut-off capacities were significantly enhanced, reaching 19876.5 mAh g⁻¹ and 16465.6 mAh g⁻¹ at a current density of 200 mA g⁻¹ in ambient air and humid oxygen, respectively.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 23","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144281357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thermal and pH Sensitive Blends Formed by Chitosan and Poly(N-Vinylcaprolactam)","authors":"Djalma A. Oliveira,&nbsp;Maria E. G. Barros,&nbsp;Grazielle R. Cerqueira,&nbsp;Yêda M. B. Almeida,&nbsp;Carolina L. Morelli","doi":"10.1002/slct.202500046","DOIUrl":"https://doi.org/10.1002/slct.202500046","url":null,"abstract":"<p>The development of smart polymeric films capable of responding to external and internal stimuli is of great interest in the biomedical and industrial fields for applications that require controlled drug release through pH variation, thermal stimuli, or both. This study aimed to develop and characterize polymeric blends composed by chitosan (CS) and poly(<i>N</i>-vinylcaprolactam) (PNVCL) with dual thermal and pH responsiveness. The films were prepared by solution casting using different CS/PNVCL ratios (90/10, 70/30, and 50/50) and characterized by ATR-FTIR, TGA, DSC, SEM, s-SNOM, contact angle, opacification, and swelling tests. FTIR and s-SNOM confirmed interaction and partial miscibility between the polymers. The films exhibited thermoresponsiveness, changing from transparent to opaque in temperatures from 25 °C to 32 °C, depending on composition. The pH responsiveness analysis indicated that the films demonstrated a greater increase in diameter (more than 80%), when subjected to acidic solution. The blend films presented Tg values of 72.38 °C, 140.41 °C, and 142.22 °C for the CS/PNVCL compositions 90/10, 30/70, and 50/50, respectively, intermediate to those observed for the pure precursor polymers (68.74 °C for CS and 182.39 °C for PNVCL). To the best of our knowledge, studies on solid polymeric systems responsive to pH and temperature, like those developed in this work, have not been performed.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 23","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144281386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to “Best of both worlds? Linking comprehensive and noncomprehensive cancer centers”","authors":"Carla Thamm RN, PhD,&nbsp;Elise Button RN, PhD,&nbsp;Sanchia Aranda RN, PhD,&nbsp;Raymond J. Chan RN, PhD","doi":"10.1002/cncr.35908","DOIUrl":"https://doi.org/10.1002/cncr.35908","url":null,"abstract":"","PeriodicalId":138,"journal":{"name":"Cancer","volume":"131 12","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144281533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatiotemporal analysis of proteins in single live cells: methods and applications.","authors":"Yanrong Wen, Fenxia Lin, Zhen Liu","doi":"10.1002/cbic.202500336","DOIUrl":"https://doi.org/10.1002/cbic.202500336","url":null,"abstract":"<p><p>The spatiotemporal detection of proteins within living cells presents a persistent challenge. This complexity arises from the dynamic nature of cellular environments, where proteins interact in a highly regulated manner. Some innovative methodologies collectively represent significant strides toward overcoming the challenges associated with spatiotemporal protein detection in living cells. They are crucial for elucidating cellular biology and advancing theranostic technologies. Nonetheless, the spatial and temporal organization of organelles within living cells remains inadequately characterized. Currently, there is a lack of review articles that comprehensively survey the progress made in recent years. This review aims to fill this gap by providing an extensive overview of recent advancements in protein analysis within individual living cells, along with their significant applications. In this review, we survey the recent technical advances in protein spatio-temporal analysis in single live cells and briefly discuss the prospects and challenges of this direction.</p>","PeriodicalId":140,"journal":{"name":"ChemBioChem","volume":" ","pages":"e202500336"},"PeriodicalIF":2.6,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144281802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}