Wiley最新文献

{"title":"Response to Letter to Editor From Brown et al.","authors":"D J Handelsman, S Bermon","doi":"10.1002/dta.3917","DOIUrl":"https://doi.org/10.1002/dta.3917","url":null,"abstract":"","PeriodicalId":160,"journal":{"name":"Drug Testing and Analysis","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144797740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluid Shear-Controlled Pro/Anti-Inflammatory Osteomodulatory Construct for Drug-Free Immune Activation Through Cationic Ion Channel Activation.","authors":"Keya Ganguly, Aayushi Randhawa, Sayan Deb Dutta, Jieun Lee, Youjin Seol, Mehran Mohammad Hossein Pour, Tejal V Patil, Rumi Acharya, Ki-Taek Lim","doi":"10.1002/adhm.202500404","DOIUrl":"https://doi.org/10.1002/adhm.202500404","url":null,"abstract":"<p><p>Effective bone regeneration requires the integration of immune and mechanical signals, which current biomaterials often fail to achieve. To address this, an immunomodulatory scaffold is developed combining 3D printing and electrospinning, designed to mimic the bone and periosteum. The scaffold features an outer electrospun nanofiber mat and an inner 3D-printed core, creating a biomimetic structure that facilitates the polarization of macrophages into pro-inflammatory (M1) and anti-inflammatory (M2) states under physiological fluid shear stress (FSS). RNA sequencing revealed the pivotal role of ion channels, particularly potassium channels, in the dynamic polarization of macrophages. The scaffold also supports mesenchymal stem cell-driven osteogenesis, establishing a synergistic environment for bone repair. This dual-function scaffold holds promise for enhancing tissue regeneration, especially in immune-compromised conditions, by integrating mechanotransduction and immune modulation within a single platform. Our findings provide a novel approach to overcoming the limitations of existing biomaterials and expanding their applications in regenerative medicine.</p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e00404"},"PeriodicalIF":9.6,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated Risk of Cerebral Arteriovenous Malformation Rupture during Pregnancy and Puerperium.","authors":"Haibin Zhang, Heze Han, Yuqing Jiao, Yahui Zhao, Li Ma, Ruinan Li, Zhipeng Li, Anqi Li, Kexin Yuan, Qinghui Zhu, Chengzhuo Wang, Yukun Zhang, Junlin Lu, Debin Yan, Dezhi Gao, Geng Guo, Xun Ye, Youxiang Li, Shibin Sun, Hao Wang, Yuanli Zhao, Yu Chen, Rong Wang, Limin Feng, Xiaolin Chen","doi":"10.1002/ana.70014","DOIUrl":"https://doi.org/10.1002/ana.70014","url":null,"abstract":"<p><strong>Objective: </strong>Cerebral arteriovenous malformations (AVM) pose a significant risk during pregnancy because of hormonal changes and increased hemodynamic stress. This study aims to assess the risk of AVM rupture during pregnancy and puerperium and to identify risk factors associated with rupture.</p><p><strong>Methods: </strong>This prospective cohort study included 588 women with AVMs and a history of pregnancy, enrolled from a nationwide registry in China between August 2011 and August 2021. A case-crossover design was used to compare rupture risk during pregnancy, puerperium, and non-pregnancy periods, adjusting for clinical and morphological factors. Multivariable logistic regression analysis identified independent risk factors.</p><p><strong>Results: </strong>The risk of AVM rupture was significantly higher during pregnancy compared to non-pregnancy periods (4.5% vs 1.6%; risk ratio [RR], 3.1; 95% confidence interval [CI], 2.3-4.2; p < 0.001). The risk was particularly elevated during the second and third trimesters. Key factors independently associated with increased rupture risk included adolescent or advanced-age pregnancy (adolescent ≤19 years or advanced ≥35 years, odds ratio [OR], 8.32; 95% CI, 2.09-28.12, p = 0.001), a history of AVM rupture before pregnancy (OR, 4.20; 95% CI, 1.37-11.40; p = 0.007), diffuse nidus (OR, 2.32; 95% CI, 1.07-5.12; p = 0.033), and multifetal pregnancy (OR 18.31; 95% CI, 1.14-293.27; p = 0.040).</p><p><strong>Interpretation: </strong>Pregnancy substantially increases the risk of AVM rupture, particularly during the second and third trimesters and compared to pre-first pregnancy periods. Risk factors such as adolescent or advanced-age pregnancy and multifetal pregnancy further increase the risk. These findings underscore the importance of tailored management during pregnancy for optimizing maternal and fetal outcomes. ANN NEUROL 2025.</p>","PeriodicalId":127,"journal":{"name":"Annals of Neurology","volume":" ","pages":""},"PeriodicalIF":7.7,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diffusion and Surface Effects on Sodium-Promoted MoS₂ Growth Observed in Operando.","authors":"Jehyun Oh, Yoonbeen Kang, Jae Hun Seol, Yong Hui Kim, Jinyoung Seo, Sang Uck Lee, Sang-Yong Ju","doi":"10.1002/smtd.202500813","DOIUrl":"https://doi.org/10.1002/smtd.202500813","url":null,"abstract":"<p><p>Understanding precursor diffusion and substrate interaction is key to advancing chemical vapor deposition (CVD) of transition metal dichalcogenides (TMCs), yet direct observation has remained a challenge due to limited real-time observation. Here, MoS₂ growth is directly monitored to investigate the kinetics and influence of the precursor/sodium droplet eutectic (SODE). Serving as a catalyst, SODE migrates from the basal plane to the edges and substrate interface, promoting growth and enabling grain translation and rotation. Kinetic analysis shows MoS₂ grows more readily on its own surface than on SiO₂, indicating a thermodynamic-kinetic interplay supported by density functional theory calculations. Notably, larger SODE droplets enhance such grain dynamics, while submicron-scale SODE exhibits extended diffusion, enabling uniform, large-area growth. These findings highlight the critical role of molten metal diffusion in growth continuity and provide new insights for optimizing scalable, cost-effective TMC fabrication.</p>","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e00813"},"PeriodicalIF":9.1,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary Delivery of siRNA Anti-TNFα-loaded Lipid Nanoparticles for Rapid Recovery in Murine Acute Lung Injury.","authors":"Qinglin Wang, Jihana Achour, Laila Emam, Younes Louaguenouni, Catherine Cailleau, Françoise Mercier-Nomé, Séverine Domenichini, Claudine Delomenie, Sezen Gul, Juliette Vergnaud, Nicolas Tsapis, Arnaud Mansart, Djillali Annane, Francois Fay, Elias Fattal","doi":"10.1002/adhm.202500695","DOIUrl":"https://doi.org/10.1002/adhm.202500695","url":null,"abstract":"<p><p>This study investigates the potential of pulmonary delivery of siRNA as an emergency therapy for acute lung injury (ALI). To obtain a quick anti-inflammatory response, TNF-α, a critical pro-inflammatory cytokine, is knocked down for its early involvement in inflammatory responses. Therefore, TNF-α siRNA-lipid nanoparticles (LNPs) are designed and characterized for cellular uptake in lipopolysaccharide (LPS)-activated RAW264.7 murine macrophages, primary alveolar macrophages, and neutrophils from a murine ALI model. Intracellular trafficking and siRNA cytoplasmic release are evaluated in untreated and LPS-activated RAW264.7 cells. LPS-activated cells exhibit a fast and strong uptake of LNPs, including in primary cells. In RAW264.7 cells, significant endosomal escape and siRNA cytoplasmic release are observed after 16 h. In vitro efficacy studies reveal consistent TNF-α inhibition across pre-, co-, and post-incubation protocols, confirming the versatility of siRNA-LNPs in preventive or curative conditions. After intratracheal administration of TNF-α siRNA-LNPs in a murine ALI model, the distribution of LNPs demonstrates an accumulation in immune cells, including macrophages and neutrophils, reducing TNF-α and IL-6 levels, indicating a rapid anti-inflammatory effect. This work underscores the efficacy of TNF-α siRNA-LNPs in treating lung inflammatory diseases like ALI and highlights the importance of optimizing LNP distribution and delivery timing to enhance therapeutic outcomes.</p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e00695"},"PeriodicalIF":9.6,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144797617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Role of Kisspeptin in Polycystic Ovary Syndrome and Its Associated Pregnancy Complications.","authors":"Shaohua Zhang, Xinmeng Sun, Haiyun Guan, Rongmin Wang, Wei Zhang, Hexia Xia","doi":"10.1111/obr.70008","DOIUrl":"https://doi.org/10.1111/obr.70008","url":null,"abstract":"<p><p>Polycystic ovary syndrome (PCOS) is a common endocrine disorder with a complex pathogenesis that includes disordered follicle development, hypothalamic-pituitary-ovarian (HPO) axis dysfunction, hyperandrogenemia, and insulin resistance. The risk of complications during pregnancy, such as gestational diabetes mellitus (GDM) and preeclampsia (PE), among PCOS patients is higher than that in the general population. Kisspeptin (KP) is a peptide hormone widely expressed in the hypothalamus, limbic system, gonads, pancreas, and liver; it is highly expressed in the placenta and is considered to play an important role in pregnancy. Therefore, the aim of this review is to summarize the complex relationships among KP levels and pregnancy complications in PCOS and to provide a comprehensive understanding of the role of KP throughout pregnancy in PCOS patients. In our summary of the existing research, we provide information regarding the direct impact of high prepregnancy KP levels in PCOS patients on early embryo implantation and placental development, leading to abnormal KP levels during pregnancy and ultimately increasing the risk of complications such as gestational GDM and PE.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e70008"},"PeriodicalIF":7.4,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144797695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proteomic Analysis of Bone Marrow CD138+ Cells to Identify Proteins Associated With the Response of Multiple Myeloma Patients to Commonly Used Therapeutic Regimens.","authors":"Foteini Paradeisi, Aggeliki Tserga, Vasiliki Lygirou, Manousos Makridakis, Rafael Stroggilos, Grigoris Georgiou, George M Spyrou, Ioannis V Kostopoulos, Christine-Ivy Liacos, Aikaterini Termentzi, Meletios A Dimopoulos, Ourania Tsitsilonis, Antonia Vlahou, Efstathios Kastritis, Jerome Zoidakis","doi":"10.1002/pmic.70025","DOIUrl":"https://doi.org/10.1002/pmic.70025","url":null,"abstract":"<p><p>Multiple myeloma (MM) remains incurable; gaps in our understanding of MM molecular pathogenesis and drugs' resistance mechanisms are involved in the failure of therapies. This study aims to identify proteins significantly impacting MM patients' response to commonly used therapeutic regimens. Bone marrow CD138+ selected plasma cells were isolated from patients who had achieved Response (Responders, R) and those who were Non-Responders (NR) to their primary MM therapy. We used LC-MS/MS to investigate the proteomic profile of MM samples, followed by bioinformatics analysis. We identified 1190 proteins, of which 230 showed a statistically significant difference between R and NR, with 27 proteins being upregulated and 203 downregulated in R compared to NR. Pathway enrichment analysis identified pathways related to the immune response and protein synthesis regulation, closely associated with MM progression and response to therapy. The results were validated through individual RNA dataset analysis, corroborating the differential expression of several proteins, including proteins associated with MM (e.g., MIF, ILF3) as well as novel findings (e.g., DCPS and SET). Collectively, proteomics data obtained from R and NR to MM therapy displayed significant changes in the immune system and protein synthesis regulation, supporting their potential role in progression and therapeutic response of MM.</p>","PeriodicalId":224,"journal":{"name":"Proteomics","volume":" ","pages":"e70025"},"PeriodicalIF":3.9,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144797698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Storage Potential of Soil Functional Carbon Fractions in the World's Largest Plantations.","authors":"Siyu Ren, Hui Wang, Tao Zhou, Chuankuan Wang, Zhenghu Zhou, Shirong Liu","doi":"10.1002/advs.202504995","DOIUrl":"https://doi.org/10.1002/advs.202504995","url":null,"abstract":"<p><p>The expansion of planted forests is one of the most effective natural climate solutions. However, increasing forest age and climate change lead to weaken biomass carbon sink, highlighting the urgency of improving the storage of functional soil organic carbon (SOC) to maintain a high level of carbon sink on a long-time scale. Using data from 501 planted forests and 564 natural forests across China, it is found that climate warming and drying increase the loss of topsoil (0-20 cm) mineral-associated (MAOC) and particulate organic carbon (POC) during the conversion of natural forests to plantations. High-precision random forest models for MAOC (77%) and POC (75%) derive the storage of the functional SOC in planted and natural forests. The total deficit of SOC in plantations compared to natural forests is 2.172.52 1.87Pg SOC (mean with 5% and 95% quantile). This substantial potential can be gained by plantation management, such as close-to-nature management. The minimal (14.61 Pg C), intermediate (22.36 Pg C), and ambitious (29.79 Pg C) objectives of SOC storage potential, providing science-based targets for enhancing soil carbon sinks, are also estimated. Overall, these findings provide a transferable framework to assess functional SOC benchmarks and targets for policymakers and highlight the strategic role of plantation soils for global carbon neutrality goals.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e04995"},"PeriodicalIF":14.1,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144797709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of hydroxyurea (hydroxycarbamide) in a national sickle cell disease programme in Ghana.","authors":"Duah Dwomoh, Daniel Nana Yaw Abankwah, Amma A Benneh-Akwasi Kuma, Jonathan Quartey, Kwaku Marfo, Jonathan Spector, Etta Forson Addo, Olufolake Egbujo, Solomon Fiifi Ofori-Acquah, Kwaku Ohene-Frempong, Justice Nonvignon","doi":"10.1111/bjh.70079","DOIUrl":"https://doi.org/10.1111/bjh.70079","url":null,"abstract":"<p><p>Hydroxyurea (hydroxycarbamide; HU) has been shown to be a safe and effective drug for individuals living with sickle cell disease (SCD) in Africa. However, reports of large-scale use of HU outside of controlled trial settings are limited on the continent. Access to HU in Ghana has improved through a major public-private partnership aimed at enhancing holistic care for communities affected by SCD. We evaluated the effectiveness of this programme through the measurement of biomarkers identified from health records, changes in clinical outcomes and quality of life (QoL) reported through interviews with participants and/or caregivers. The haemoglobin (Hb) levels of participants enrolled in the programme between September 2019 and July 2023 (n = 1549) increased on average by 0.55 g/dL (p < 0.001), with 9.2% of participants achieving Hb ≥10 g/dL. Six hundred participants and caregivers interviewed from April to November 2023 reported a significant reduction in the number of pain crises, malarial episodes, incidence of blood transfusions and rate of hospitalisations. Adults and children with SCD reported improved QoL in areas of physical, emotional, social and school-related functioning. Lessons learned are expected to inform future efforts in Ghana and may support HU access programmes in other countries where SCD is highly endemic.</p>","PeriodicalId":135,"journal":{"name":"British Journal of Haematology","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144797717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functionalized Reduced Graphene Oxide-Based Nanocomposite Hydrogels for Enhanced Osteogenesis in Bone Tissue Engineering.","authors":"George Mihail Vlăsceanu, Cătălina Ionela Zamfir, Cornel Baltă, Hildegard Herman, Alina Ciceu, Maria Alexandra Duma, Mariana Ioniță, Roxana-Cristina Popescu, Anca Hermenean","doi":"10.1002/adhm.202501941","DOIUrl":"https://doi.org/10.1002/adhm.202501941","url":null,"abstract":"<p><p>This study presents the development of nanocomposite hydrogels that integrate functionalized reduced graphene oxide (rGO) derivatives carboxylated (CBX) and aminated (AMN) in combination with gellan gum, gelatin, and cellulose nanofibrils (CNFs) to enhance osteogenesis for bone tissue engineering. Their synthesis involves ultrasound exfoliation, genipin crosslinking, and freeze-drying. Micro-computed tomography (µCT) reveals highly porous, interconnected architectures facilitating nutrient diffusion and cell infiltration. CBX/AMN scaffolds exhibit superior hydration capacity and a biphasic degradation profile. Spectroscopically, enhanced interfacial interactions were confirmed, contributing to the overall structural stability of the hydrogels. In vitro, all scaffolds are cytocompatible, sustain cell viability, and promote osteogenic differentiation consistent with adaptive cellmaterial interactions. Subcutaneous implantation in mice confirms scaffold biocompatibility, showing no signs of inflammation or foreign body response. Histological and immunofluorescence analyses reveal osteogenic potential, with enhanced mineralization and elevated expression of osteopontin and osteocalcin. µCT imaging of explants quantifies ectopic mineralization, spatial deposition patterns, and bone mineral density, correlating scaffold architecture and composition with osteogenic performance. These findings suggest that the synergistic integration of functionalized rGO, CNFs, and biopolymers results in scaffolds with enhanced structural and biological properties, highlighting their potential for design optimization and clinical translation in bone regenerative medicine.</p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e01941"},"PeriodicalIF":9.6,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}