Wiley最新文献

{"title":"Genetically Predicted Frailty Index Is Associated With Increased Risk of Multiple Metabolic Diseases: 175 226 European Participants in a Mendelian Randomization Study","authors":"Hexing Wang,&nbsp;Haifeng Zhang,&nbsp;Dongliang Tang,&nbsp;Yinshuang Yao,&nbsp;Junlan Qiu,&nbsp;Xiaochen Shu","doi":"10.1111/1753-0407.70062","DOIUrl":"https://doi.org/10.1111/1753-0407.70062","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>A relationship between frailty index (FI) and metabolic diseases (MDs) has been reported in previous observational studies. However, the causality between them remains unclear. This study aimed to examine the causal effect of FI on MDs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We performed a bidirectional two-sample Mendelian randomization (MR) study. A recent large-scale genome-wide association study (GWAS) provided available data associated with FI, and summary statistics on eight MDs were collected from the IEU OpenGWAS database. Inverse variance weighted (IVW) was used as the main analysis to estimate causal effects, together with MR pleiotropy residual sum and outlier (MR-PRESSO), MR-Egger, Cochran's Q test, pleiotropy test, leave-one-out method, and MR Steiger analysis were used in the sensitivity analyses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Our MR study demonstrated for the first time that elevated FI was causally associated with an increased risk of MDs including obesity (odds ratio [OR] = 1.78; 95% confidence interval [CI]: 1.17–2.70; <i>p</i> = 0.0075), T2DM (OR = 1.67; 95% CI: 1.24–2.24; <i>p</i> = 6.95 × 10⁻⁴), gout (OR = 2.45; 95% CI: 1.29–4.64; <i>p</i> = 0.006), hypothyroidism (OR = 1.96; 95% CI: 1.47–2.60; <i>p</i> = 3.47 × 10⁻⁶), and HTN (OR = 2.17; 95% CI: 1.72–2.74; <i>p</i> = 5.25 × 10⁻¹¹). However, no causal association was found between FI and osteoporosis, vitamin D deficiency, and hyperthyroidism.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our findings support a causal relationship between FI and multiple MDs. This is crucial for the prevention of associated MDs in patients with frailty.</p>\u0000 </section>\u0000 </div>","PeriodicalId":189,"journal":{"name":"Journal of Diabetes","volume":"17 3","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1753-0407.70062","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Skin Autofluorescence and Coronary Heart Disease in Chinese General Population: A Cross-Sectional Study","authors":"Qingzheng Wu,&nbsp;Yu Cheng,&nbsp;Hongyan Liu,&nbsp;Yuepeng Wang,&nbsp;Bing Li,&nbsp;Yiming Mu","doi":"10.1111/1753-0407.70061","DOIUrl":"https://doi.org/10.1111/1753-0407.70061","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The aim of this study was to investigate the relationship between SAF and CHD in the general population of China and to assess the feasibility of SAF used as a predictor of CHD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study was nested within the prospective study REACTION (Cancer Risk Assessment in Chinese Diabetic Population) which included a total of 5806 eligible participants from two communities located in urban Beijing in 2018. SAF were measured using a fluorescence detector (DM Scan). CHD was the study endpoint and was determined by a face-to-face clinical survey. Pearson's correlation analysis, linear regression analysis, and binary logistic regression analysis were used to examine the association between SAF and CHD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The overall prevalence of CHD in the general population was 12.1%. Logistic analysis showed that after full adjustment for confounding factors, the risk of CHD increased significantly with increasing lnSAF quartiles (<i>p</i>-trend &lt; 0.05). Compared to Q1 group, the multivariate adjusted ORs of Q2 and Q3 groups were 1.071 (0.817, 1.404), 1.025 (0.781, 1.344), respectively, and the OR was markedly increased at Q4 (OR = 1.377 [1.043, 1.817]). When lnSAF was a continuous variable, the risk of CHD increased with the elevation of lnSAF level. Stratified analysis showed that in subgroups with overweight (24–28 kg/m²), eGFR &lt; 60 mL/min/1.73 m², and diabetes mellitus (DM), lnSAF was still significantly correlated with CHD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In Chinese general population, higher lnSAF is independently associated with increased risk of CHD, and noninvasive SAF holds the potential to be a biomarker for CHD risk evaluation and stratification.</p>\u0000 </section>\u0000 </div>","PeriodicalId":189,"journal":{"name":"Journal of Diabetes","volume":"17 3","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1753-0407.70061","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Type VI Secretion System of Sinorhizobium fredii USDA257 Is Required for Successful Nodulation With Glycine max cv Pekin","authors":"Pedro José Reyes-Pérez,&nbsp;Irene Jiménez-Guerrero,&nbsp;Ana Sánchez-Reina,&nbsp;Cristina Civantos,&nbsp;Natalia Moreno-de Castro,&nbsp;Francisco Javier Ollero,&nbsp;Jacinto Gandullo,&nbsp;Patricia Bernal,&nbsp;Francisco Pérez-Montaño","doi":"10.1111/1751-7915.70112","DOIUrl":"https://doi.org/10.1111/1751-7915.70112","url":null,"abstract":"<p>The symbiotic relationship between rhizobia and legumes is critical for sustainable agriculture and has important economic and environmental implications. In this intricate process, rhizobial bacteria colonise plant roots and induce the formation of specialised plant organs, the nodules. Within these structures, rhizobia fix environmental nitrogen into ammonia, significantly reducing the demand for synthetic fertilisers. Multiple bacterial secretion systems (TXSS, Type X Secretion System) are involved in establishing this symbiosis, with T3SS being the most studied. While the Type 6 Secretion System (T6SS) is known as a “nanoweapon” commonly used by diderm (formerly gram-negative) bacteria for inter-bacterial competition and potentially manipulating eukaryotic cells, its precise role in legume symbiosis remains unclear. <i>Sinorhizobium fredii</i> USDA257, a fast-growing rhizobial strain capable of nodulating diverse legume plants, possesses a single T6SS cluster containing genes encoding structural components and potential effectors that could target plant cells and/or act as effector-immunity pairs. Our research reveals that this T6SS can be induced in nutrient-limited conditions and, more importantly, is essential for successful nodulation and competitive colonisation of <i>Glycine max</i> cv Pekin. Although the system did not demonstrate effectiveness in eliminating competing bacteria in vitro, its active presence within root nodules suggests a sophisticated role in symbiotic interactions that extends beyond traditional interbacterial competition.</p>","PeriodicalId":209,"journal":{"name":"Microbial Biotechnology","volume":"18 3","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1751-7915.70112","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When Science Meets Creativity: Elevating Microbiology Education With Art—Two Personal Experiences","authors":"Luis Andrés Yarzábal Rodríguez,&nbsp;Ramón Alberto Batista-García","doi":"10.1111/1751-7915.70099","DOIUrl":"https://doi.org/10.1111/1751-7915.70099","url":null,"abstract":"<p>Science communicators are more critical than ever in a time when misinformation and hoaxes dominate social media, especially during global emergencies like the COVID-19 outbreak. Researchers are good at communicating with peers but often struggle to explain complex ideas to the public. As shown previously, expanding outreach by combining science and art is not only possible, but effective. In the case of microbiology, the synergy between these two apparently divorced areas can help educating our communities and raising microbiological awareness, especially among students. Since Alexander Fleming's pioneering attempts, microorganisms have fascinated artists. Art may help us demystifying microbes and making them more approachable, improving public involvement with science. This article presents two personal experiences using art to teach and communicate scientific ideas (mainly from the microbiology field) to our fellow citizens. Above all, we emphasise the importance of contributing to the scientific literacy of our societies at all ages—including underrepresented and disadvantaged groups—by exploring novel ways to address this gap. By doing so, we align with the concepts and aims of the International Microbiology Literacy Initiative (IMiLI).</p>","PeriodicalId":209,"journal":{"name":"Microbial Biotechnology","volume":"18 3","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1751-7915.70099","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drivers of Vegetation Structure Differ Between Proposed Natural Reference Conditions for Temperate Europe","authors":"Elena A. Pearce,&nbsp;Charles W. Davison,&nbsp;Florence Mazier,&nbsp;Signe Normand,&nbsp;Ralph Fyfe,&nbsp;Maria-Antonia Serge,&nbsp;Paolo Scussolini,&nbsp;Jens-Christian Svenning","doi":"10.1111/geb.70020","DOIUrl":"https://doi.org/10.1111/geb.70020","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Aim&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Pre-degradation baseline conditions (references) provide crucial context for restoration actions. Here, we compare vegetation structure and its driving processes across the main pre-agricultural references discussed for temperate Europe: the Last Interglacial and the early-mid Holocene—before and after the arrival of &lt;i&gt;Homo sapiens&lt;/i&gt;, respectively.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Location&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Temperate Europe.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Time Period&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The first ~4000–6000 years, excluding the initial early-successional phases, of the Last Interglacial (PAAZ III) and Holocene (8700–5700 BP).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Major Taxa Studied&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Plants.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;We use large datasets of pollen-based vegetation reconstructions (REVEALS) to compare open vegetation, light woodland and closed forest between the two periods. We use Random Forest modelling and downscaled climate data to assess whether climate-vegetation relations were consistent between periods, as expected if they reflected direct climatic effects on vegetation.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Open vegetation was slightly higher in the early–mid Holocene than in the Last Interglacial, averaging 20% versus 16% in paired grid cells, respectively. In contrast, light woodland cover was lower in the early–mid Holocene, with mean values of 49% compared to 57% in paired cells. The combined open vegetation and light woodland cover was high in both periods, averaging 73% in the Last Interglacial and 69% in the early–mid Holocene. Closed forest cover was similar across both periods (Holocene = 24%; Last Interglacial = 23%). Notably, openness –climate relations from the early–mid Holocene cannot predict open vegetation in the Last Interglacial.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Main Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;These findings suggest that vegetation in the early–mid Holocene and Last Interglacial was affected by persistent, substantial disturbances, which were not controlled by direct climate effects, and that the main drivers differed between the periods, with the rich megafauna of the Last Interglacial and Mesolithic people as the primary candidates. Our findings support that early–mid Holocene ecosystems were a","PeriodicalId":176,"journal":{"name":"Global Ecology and Biogeography","volume":"34 3","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/geb.70020","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Effect of Distance Between Dental Abutments on the Accuracy of One-Step and Two-Step Impression Techniques With Polyvinyl Siloxane (PVS) Material","authors":"Seyyed Ahmad Ghoraishian,&nbsp;Mohsen Khataminia,&nbsp;Zahra Shahramian,&nbsp;Maryam Zare,&nbsp;Mina Mohaghegh","doi":"10.1002/cre2.70100","DOIUrl":"https://doi.org/10.1002/cre2.70100","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The aim of this study was to evaluate the effect of distance between dental abutments on the accuracy of one-step and two-step impression techniques with polyvinyl siloxane (PVS) material.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Four master models were fabricated with different interabutment distances equal to one, two, three, and four premolar lengths 1–4 (L1, L2, L3, and L4). Seven one-step impressions were taken from each master model using PVS impression material (Group A, <i>n</i> = 7). For two-step impressions, a 1.5 mm polyethylene spacer was used over each master model, and impressions were taken (Group B, <i>n</i> = 7). Scans from the casts were superimposed over the master model scans. Accordingly, differences were measured and compared with statistical tests (Kolmogorov–Smirnoff test, Mann–Whitney test, and Friedman's test) to evaluate the effect of interabutment distance within each impression technique group and also compare the one-step and two-step impression techniques. <i>p</i> value &lt; 0.05 was considered statistically significant.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A statistically significant difference was noted among the different edentulous areas in the one-step impression technique group (Group A, <i>p</i> = 0.010). At edentulous span, a statistically significant difference was recorded (<i>p</i> = 0.047) with two-step impression technique being more accurate compared to the one-step impression technique. Friedman's pairwise analysis in Group A demonstrated a significance between one premolar and four premolar interabutment distance groups (<i>p</i> = 0.006).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The accuracy of the one-step impression is significantly affected by the increase in interabutment distance from one premolar to four premolar edentulous.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70100","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Behind phyllotaxis, within the meristem: a REM-ARF complex shapes inflorescence in Arabidopsis thaliana","authors":"Francesca Caselli,&nbsp;Carlotta Ferrario,&nbsp;Veronica Maria Beretta,&nbsp;Sri Amarnadh Gupta Tondepu,&nbsp;Renaud Dumas,&nbsp;Humberto Herrera-Ubaldo,&nbsp;Stefan de Folter,&nbsp;Martin M. Kater,&nbsp;Veronica Gregis","doi":"10.1111/tpj.70041","DOIUrl":"https://doi.org/10.1111/tpj.70041","url":null,"abstract":"<p>Inflorescence architecture is established during the early stages of reproductive development and depends on the activity and identity of meristems. In <i>Arabidopsis thaliana</i>, the floral meristems (FMs), which will develop into flowers, arise with precise spatiotemporal regulation from the inflorescence meristem (IM). The outcome of this process is a geometrically organized structure characterized by a reiterated pattern called phyllotaxis, in which successive organs arise at specific divergence angles of 137.5°. Here we show that REM34 and REM35 transcription factors control phyllotactic patterning through cooperative interaction with ARF7 and ARF19, influencing the cell cycle rate and thus the IM dimension. Our proposed model suggests that ARF7 and ARF19, whose activity is triggered by auxin accumulation, interact with REM34 and REM35 to regulate two auxin-induced genes, <i>LBD18</i> and <i>PUCHI</i>, whose mutants phenocopy the permutated phyllotactic pattern of <i>rem34 rem35</i> and <i>arf7 arf19</i>. This complex also restricts cell cycling activity to specific areas of the meristem, indirectly determining its dimension and ultimately establishing FM positioning and phyllotaxis. Reiterative patterns are found in morphogenetic processes of complex organisms, and phyllotaxis has been employed to understand the mechanisms behind this regularity. Our research broadens the knowledge on this mechanism which is also strictly correlated with yield.</p>","PeriodicalId":233,"journal":{"name":"The Plant Journal","volume":"121 5","pages":""},"PeriodicalIF":6.2,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/tpj.70041","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Ectopic expression of human airway trypsin-like protease 4 in acute myeloid leukemia promotes cancer cell invasion and tumor growth”","authors":"","doi":"10.1002/cam4.70700","DOIUrl":"https://doi.org/10.1002/cam4.70700","url":null,"abstract":"<p>Yan R, Liu M, Hu Y, et al. Ectopic expression of human airway trypsin-like protease 4 in acute myeloid leukemia promotes cancer cell invasion and tumor growth. <i>Cancer Med.</i> 2019;8:2348–2359, https://doi.org/10.1002/cam4.2074.</p><p>It was brought to our attention that errors occurred in Figures 3B and 7E. In Figure 3B, the lines and circles were shifted during figure preparation, leaving an impression that two low data points were in negative values. The correlation coefficient was 0.804, as listed in Table S2. The <i>R</i>² value was miscalculated and should be 0.646. In Figure 7E, two images taken from the same tissue section of the shR group were mistakenly used in the shH and shR groups. Corrected Figures 3B and 7E are included below. The conclusions of the paper remain unchanged.</p>","PeriodicalId":139,"journal":{"name":"Cancer Medicine","volume":"14 5","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cam4.70700","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stress Distribution Pattern in Mandibular Overdenture Designs Supported by Three Dental Implants: A 3D Finite Element Analysis","authors":"Negin Aminianpour,&nbsp;Marzieh Alikhasi,&nbsp;Mostafa Shabanpour Kasari,&nbsp;Hashem Yousefi,&nbsp;Hakimeh Siadat","doi":"10.1002/cre2.70060","DOIUrl":"https://doi.org/10.1002/cre2.70060","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The purpose of this study was to assess the implant-supported overdenture stress distribution pattern in cancellous and cortical bone, dental implants, and prosthetic components, and its displacement by using finite element analysis (FEA).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>An edentulous model of the mandible was designed with three dental implants placed at the sites of canine teeth and the midline. Six groups were designed with isolated (ball and locator) and splinted (conventional bar and a CAD/CAM milled bar with cast and screw ball) attachments with and without a cantilever using SolidWorks 2022 software. The stress distribution pattern in the surrounding bone, implants, and prosthetic components (attachments, caps, housings, and screws) was evaluated following the application of 150 N force vertically and 105 N load with a 30° angle relative to the first molar site using Abaqus/CAE 2021 software. The implant-supported overdenture displacement was also evaluated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The ball attachment caused the highest stress in the attachments (363 and 896 MPa) and housings (375 and 1187 MPa) under vertical and oblique loadings, and cancellous bone (6 MPa under vertical loading). The pattern of stress distribution was variable following vertical and oblique loading in the cortical bone and dental implants in different groups. The locator attachment resulted in lower stress distribution in bone, implants, and prosthetic components. In splinted groups, the cantilever designs caused lower stress in bone, implants, and prosthetic components in comparison with designs without a cantilever. The conventional and milled bar did not show any mechanical difference.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Considering the stress distribution patterns, the locator attachment is preferred to the ball isolated attachment, and the cantilever design is preferred among the splinted types. Isolated attachments were more effective in controlling the displacement. Also, conventional and milled bars did not show any superiority over each other.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70060","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cover Image, Volume 40, Issue 7","authors":"","doi":"10.1111/mice.13449","DOIUrl":"https://doi.org/10.1111/mice.13449","url":null,"abstract":"<p><b>The cover image</b> is based on the article <i>Multifidelity graph neural networks for efficient and accurate mesh-based partial differential equations surrogate modeling</i> by Negin Alemazkoor et al., https://doi.org/10.1111/mice.13312.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":156,"journal":{"name":"Computer-Aided Civil and Infrastructure Engineering","volume":"40 7","pages":""},"PeriodicalIF":8.5,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/mice.13449","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}