IF 6.6 2区化学

ChemSusChem Pub Date : 2025-10-23 DOI: 10.1002/cssc.70229

Mariko Teshima, Robert Genth, Tenuun Bayaraa, Manuel Döring, Barbara Beer, Gerhard Schenk, Volker Sieber

{"title":"Front Cover: Microfluidic-Assisted Evolution of a Robust NAD+-Dependent Enzyme with Improved Isobutanol Tolerance at Elevated Temperatures (ChemSusChem 20/2025)","authors":"Mariko Teshima, Robert Genth, Tenuun Bayaraa, Manuel Döring, Barbara Beer, Gerhard Schenk, Volker Sieber","doi":"10.1002/cssc.70229","DOIUrl":"https://doi.org/10.1002/cssc.70229","url":null,"abstract":"The Front Cover shows a microfluidic chip that was used in an enzyme engineering approach utilizing microdroplet-based UHTS to optimize an aldehyde dehydrogenase towards higher temperature stability and solvent tolerance. The optimized enzyme was then applied as part of a multi-enzyme cascade as indicated by the circle of enzyme structures above the chip. The ultimate goal is a continuous process for the conversion of glucose into isobutanol in a two-phase system using these enzymes and based on the formation of an isobutanol phase at sufficiently high concentration and with continuous removal of the organic phase, as shown by the reactor in the background. More information can be found in the Research Article by V. Sieber and co-workers (DOI: 10.1002/cssc.202501120).\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture>\u0000 </div>\u0000 </figure>","PeriodicalId":149,"journal":{"name":"ChemSusChem","volume":"18 20","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/cssc.70229","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145341902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flower-Like Covalent Organic Frameworks for Superior Corrosion Resistance and Durability in Epoxy Coatings (Small 42/2025) 花状共价有机框架在环氧涂料中的优异耐腐蚀性和耐久性（Small 42/2025）

IF 12.1 2区材料科学

Small Pub Date : 2025-10-23 DOI: 10.1002/smll.70718

Parisa Najmi, Navid Keshmiri, Mohammad Arjmand

引用次数: 0

Risk factors for DIC in paediatric APL: Insights from the CCLG-APL 2016 study. 儿科APL DIC的危险因素：来自CCLG-APL 2016研究的见解

IF 3.8 2区医学

British Journal of Haematology Pub Date : 2025-10-23 DOI: 10.1111/bjh.70211

Qingyuan Xu, Linya Wang, Shaoyan Hu, Ning Liao, Diying Shen, Xin Tian, Guoping Hao, Runming Jin, Jianxin Li, Yongjun Fang, Xiuli Ju, Ansheng Liu, Yuanyuan Zhang, Pengli Huang, Jiaole Yu, Ying Wu, Wei Lin, Peijing Qi, Jia Fan, Ruidong Zhang, Yaguang Peng, Huyong Zheng

{"title":"Risk factors for DIC in paediatric APL: Insights from the CCLG-APL 2016 study.","authors":"Qingyuan Xu, Linya Wang, Shaoyan Hu, Ning Liao, Diying Shen, Xin Tian, Guoping Hao, Runming Jin, Jianxin Li, Yongjun Fang, Xiuli Ju, Ansheng Liu, Yuanyuan Zhang, Pengli Huang, Jiaole Yu, Ying Wu, Wei Lin, Peijing Qi, Jia Fan, Ruidong Zhang, Yaguang Peng, Huyong Zheng","doi":"10.1111/bjh.70211","DOIUrl":"https://doi.org/10.1111/bjh.70211","url":null,"abstract":"To identify early risk factors for disseminated intravascular coagulation (DIC), particularly severe DIC (grade 4-5), in paediatric acute promyelocytic leukaemia (APL). One hundred and eighty-six paediatric APL patients enrolled in the Chinese Children Leukemia Group (CCLG)-APL 2016 study across 38 hospitals nationwide were grouped based on the occurrence and severity of DIC during induction therapy. DIC occurred in 52.2% of patients during induction therapy, with 7.5% developing grade 4-5 DIC. Significant differences were observed between the DIC and non-DIC groups in the proportion of patients with initial white blood cells (WBC) ≥5 × 109/L, initial platelets (PLT) ≤26 × 109/L and arsenic trioxide (ATO) use (p < 0.05). Multivariate analysis identified initial PLT ≤26 × 109/L (p = 0.002, odds ratio [OR] = 2.679, 95% confidence interval [CI]: 1.438-4.992) as an independent risk factor, while induction therapy using realgar-indigo naturalis formula (RIF) was a protective factor (p = 0.030, OR = 0.465, 95% CI: 0.232-0.929). Further analysis revealed that Fms-like tyrosine kinase 3 (FLT3) mutation (p = 0.023, OR = 11.742, 95% CI: 1.405-98.149), initial PLT ≤26 × 109/L (p = 0.017, OR = 13.784, 95% CI: 1.598-118.905) and initial bone marrow blasts ≥90% (p = 0.030, OR = 5.289, 95% CI: 1.178-23.744) were significant risk factors for grade 4-5 DIC. Initial WBC ≥5 × 109/L and PLT ≤26 × 109/L are associated with an increased risk of DIC, with PLT ≤26 × 109/L as an independent risk factor. Compared with ATO, RIF is a protective factor during induction therapy. Additionally, FLT3 mutation, PLT ≤26 × 109/L and initial bone marrow blasts ≥90% are independent risk factors for grade 4-5 DIC.","PeriodicalId":135,"journal":{"name":"British Journal of Haematology","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145342178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cohort Study on Drug Survival and Tolerability of Adalimumab Biosimilar Transitioning: Pharmaceutical Properties Do Matter. 阿达木单抗生物仿制药过渡的药物生存期和耐受性队列研究：药物特性确实重要。

IF 5.5 2区医学

Clinical Pharmacology & Therapeutics Pub Date : 2025-10-23 DOI: 10.1002/cpt.70098

Amy C D Peeters, Maike H M Wientjes, Wieland D Müskens, David F Ten Cate, Laura C Coates, Bart J F van den Bemt, Noortje van Herwaarden, Alfons A den Broeder

{"title":"Cohort Study on Drug Survival and Tolerability of Adalimumab Biosimilar Transitioning: Pharmaceutical Properties Do Matter.","authors":"Amy C D Peeters, Maike H M Wientjes, Wieland D Müskens, David F Ten Cate, Laura C Coates, Bart J F van den Bemt, Noortje van Herwaarden, Alfons A den Broeder","doi":"10.1002/cpt.70098","DOIUrl":"https://doi.org/10.1002/cpt.70098","url":null,"abstract":"There are no clinically meaningful differences between bio-originators (BO) and their biosimilars (BS) in safety and efficacy. However, differences in pharmaceutical properties, such as volume and excipient, can occur. This study aimed to compare outcomes between patients transitioning from the modernized adalimumab BO (0.4 mL/no citrate) to BS1 (0.8 mL/citrate) and from BS1 to BS2 (0.4 mL/no citrate) and outcomes for new starters. In this retrospective exploratory cohort study of RA, PsA, and axial SpA patients receiving adalimumab, the (adjusted) 12-month drug survival rates were compared between the transition from the modernized BO to BS1 (Cohort 1, 2021) and from BS1 to BS2 (Cohort 2, 2023) in existing users, and for adalimumab-naïve new starters of the originator and BS1 and BS2 (Cohorts 3 to 5). Subanalyses included drug survival separately for inefficacy and intolerability. In existing users, 983 patients transitioned to BS1, 1082 patients to BS2, with 659 patients in both cohorts. Drug survival rates at 12 months were 73% (95% CI: 70-76) and 90% (95% CI: 88-92), respectively (P < 0.001), adjusted hazard rate ratio (HRR) 0.32 (95% CI: 0.26-0.40) in favor of BS2. The HRR for discontinuation due to inefficacy and tolerability were 0.50 (95% CI: 0.37-0.67) and 0.20 (95% CI: 0.14-0.28), respectively, both favoring BS2. In adalimumab-naïve new starters also, better survival for the originator and BS2 were seen compared with BS1. In conclusion, adalimumab BS1 showed a significantly lower drug survival than BS2, primarily due to lower tolerability. These findings suggest that pharmaceutical differences can have an important impact on drug survival.","PeriodicalId":153,"journal":{"name":"Clinical Pharmacology & Therapeutics","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145342264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pd/C-Catalyzed Efficient and Selective Synthesis of Glycolic Acid from Ethylene Glycol. Pd/ c催化乙二醇高效选择性合成乙醇酸。

IF 6.6 2区化学

ChemSusChem Pub Date : 2025-10-23 DOI: 10.1002/cssc.202501839

Alban Schmoll, Yong-Wang Huo, Sufang Shao, Xiao-Feng Wu

引用次数: 0

Light Metabolically Reprograms CD8⁺ T Cells to Potentiate STING-Driven Tumor Eradication and Prevent Metastasis. 光代谢重编程CD8+ T细胞以增强sting驱动的肿瘤根除和预防转移。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2025-10-23 DOI: 10.1002/advs.202515121

Asmita Banstola, Shilin Gao, Zhengkung Zhang, Yan Dong, Prabhat Upadhyay, Quanwei Zhang, Yongli Li, Zuan-Tao Lin, Zhilong Wang, Mei X Wu

{"title":"Light Metabolically Reprograms CD8+ T Cells to Potentiate STING-Driven Tumor Eradication and Prevent Metastasis.","authors":"Asmita Banstola, Shilin Gao, Zhengkung Zhang, Yan Dong, Prabhat Upadhyay, Quanwei Zhang, Yongli Li, Zuan-Tao Lin, Zhilong Wang, Mei X Wu","doi":"10.1002/advs.202515121","DOIUrl":"https://doi.org/10.1002/advs.202515121","url":null,"abstract":"Immunotherapy remains ineffective in many solid tumors due to poor T-cell infiltration and a metabolically suppressive tumor microenvironment. A dual strategy combining low-level light (LLL) therapy with a nanoscale stimulator of interferon genes (STING) agonist formulation (nanoSTING@Mn) is presented to enhance immune activation and metabolic fitness for durable tumor immunity against T-cell lymphoma (EL4) model. NanoSTING@Mn, composed of ADU-S100 complexed with Mn2⁺ and encapsulated in biomimetic liposomes, potently activates the cGAS-STING pathway, induces a type I interferon response, and promotes lymphocyte infiltration. These monocytes polarize into M1 macrophages, suppressing regulatory T cells. Simultaneously, LLL photo-biomodulation reprograms mitochondrial metabolism in tumor-infiltrating CD8⁺ T and natural killer cells, restoring their durability and leading to complete local tumor eradication. This combination expands a distinct CD8⁺ T-cell subset with Tcf-1⁺ progenitor-exhausted features and elevated memory/effector gene expression, enhancing proliferation and cytotoxicity, as shown by single-cell RNA sequencing. Intranasal nanoSTING@Mn delivery mobilizes these LLL-revived T cells to the lung, where they differentiate into resident memory T cells and establish systemic antitumor immunity. Upon intravenous rechallenge, disseminated tumor cells are eliminated, preventing metastasis and ensuring long-term protection. This synergistic approach offers a scalable platform to boost immunotherapy efficacy and redefines immune-based metastasis prevention strategies.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e15121"},"PeriodicalIF":14.1,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145342334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronic ER Stress Triggers Cell-Surface Chaperones as the Therapeutic Targets of CAR Cells in Acute Myeloid Leukemia. 慢性内质网应激触发细胞表面伴侣作为CAR细胞治疗急性髓系白血病的靶点。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2025-10-23 DOI: 10.1002/advs.202511573

Yimin Zhou, Zhenfei Zhong, Peng Hu, Weigang Wang, Ying Song, Na Yang, Fangyan He, Yajie Li, Qi Sa, Yanmei Yang, Qinmiao Sun, Tonghua Yang, Beibei Zhang, Dahua Chen

{"title":"Chronic ER Stress Triggers Cell-Surface Chaperones as the Therapeutic Targets of CAR Cells in Acute Myeloid Leukemia.","authors":"Yimin Zhou, Zhenfei Zhong, Peng Hu, Weigang Wang, Ying Song, Na Yang, Fangyan He, Yajie Li, Qi Sa, Yanmei Yang, Qinmiao Sun, Tonghua Yang, Beibei Zhang, Dahua Chen","doi":"10.1002/advs.202511573","DOIUrl":"https://doi.org/10.1002/advs.202511573","url":null,"abstract":"Acute myeloid leukemia (AML) is a heterogeneous malignancy with low survival rates, primarily due to its inherent complexity. This underscores the urgent need to identify specific targets for precision medicine. Here, multi-omics approaches are utilized and discover that AML cells undergo chaperone-mediated chronic endoplasmic reticulum (ER) stress. Through integrative analyses of single-cell RNA-seq, cell-surface proteomes, and cellular biology, ER chaperone proteins (e.g., HSP90B1 and P4HB) are identified as potential neoantigens that translocate to the cell surface upon chronic ER stress. These results suggest that these proteins, especially in FLT3-ITD+ AML cells, show great promise as diagnostic markers and therapeutic targets. To explore the therapeutic potential, chimeric antigen receptor-natural killer (CAR-NK) cells targeting surface-localized HSP90B1 are engineered. These engineered cells show selective cytotoxicity both in vitro and in animal models. This study not only identifies neoantigens as specific biomarkers refining AML classification, but also emphasizes the potential of immunotherapy-based precision treatments for AML.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e11573"},"PeriodicalIF":14.1,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145342336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive Optical Band-Edge Characterization for Multilayered MoTe2 and Its Application in van der Waals-Stacked Heterojunction Devices (Small 42/2025) 多层MoTe2的综合光学带边特性及其在范德华堆叠异质结器件中的应用（Small 42/2025）

IF 12.1 2区材料科学

Small Pub Date : 2025-10-23 DOI: 10.1002/smll.70720

Yin-Chou Huang, Dai-Yan Yang, Luthviyah Choirotul Muhimmah, Yu-Hung Peng, Yen-Chang Su, Ching-Hwa Ho

引用次数: 0

Machine Learning-Enhanced Modular Ionic Skin for Broad-Spectrum Multimodal Discriminability in Bidirectional Human–Robot Interaction (Adv. Mater. 42/2025) 基于机器学习的模块化离子皮肤在双向人机交互中的广谱多模态识别（Adv. Mater. 42/2025）

IF 26.8 1区材料科学

Advanced Materials Pub Date : 2025-10-23 DOI: 10.1002/adma.70838

Qianqian Yang, Bingqiao Li, Mengke Wang, Gaoyang Pang, Yuyao Lu, Jiayan Li, Huayong Yang, Honghao Lyu, Kaichen Xu, Geng Yang

引用次数: 0

Via Performance to Degradation: Oxidation Mechanism of Biodegradable Polyalphaolefin Base Oil for Electric Drive Systems. 从性能到降解：电力传动系统用可生物降解聚烯烃基础油的氧化机理。

IF 2.8 4区化学

ChemPlusChem Pub Date : 2025-10-23 DOI: 10.1002/cplu.202500413

Elisabeth Distler, Joachim Albrecht, Kevin Holderied, Didem Cansu Güney, Markus Kiefel, Katharina Weber

{"title":"Via Performance to Degradation: Oxidation Mechanism of Biodegradable Polyalphaolefin Base Oil for Electric Drive Systems.","authors":"Elisabeth Distler, Joachim Albrecht, Kevin Holderied, Didem Cansu Güney, Markus Kiefel, Katharina Weber","doi":"10.1002/cplu.202500413","DOIUrl":"https://doi.org/10.1002/cplu.202500413","url":null,"abstract":"An additive-free, low-viscosity polyalphaolefin (PAO) has been oxidized under pure oxygen at elevated pressure and temperature. This biodegradable PAO base oil is a promising candidate for use as a motor-gear lubricant in electrical drive systems. The oxidation behavior is systematically investigated to evaluate its thermal stability and long-term performance. Rheological measurements are performed to assess viscosity, water content is quantified, tribological tests determine the coefficient of friction, and Fourier-transform infrared spectroscopy is used to monitor chemical changes during oxidation. All analytical methods consistently revealed a two-step oxidative degradation process. It is proposed that the first stage involves the formation of carbonyl compounds and water without compromising lubrication properties, while the second stage-triggered by hydrolysis of oxidation products-leads to chain scission and initiates the desired degradation. This two-stage mechanism is discussed in the context of technological functionality and sustainability requirements for next-generation electric drive lubricants.","PeriodicalId":148,"journal":{"name":"ChemPlusChem","volume":" ","pages":"e202500413"},"PeriodicalIF":2.8,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145342284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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