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Ultra-stretchable Transparent Hydrogels with Low Hydrophobic and Amphiphilic Monomers Using Asymmetric Crosslinker to Give Low Mechanical Hysteresis. 采用不对称交联剂制备具有低机械滞后的低疏水性和两亲性单体的超可拉伸透明水凝胶。
IF 3.7 2区 化学
Chemistry - A European Journal Pub Date : 2025-08-06 DOI: 10.1002/chem.202500778
Hiroaki Yoshida, Takanori Maeno, Ryo Kawatani, Yumi Miyaji, Hiroharu Ajiro
{"title":"Ultra-stretchable Transparent Hydrogels with Low Hydrophobic and Amphiphilic Monomers Using Asymmetric Crosslinker to Give Low Mechanical Hysteresis.","authors":"Hiroaki Yoshida, Takanori Maeno, Ryo Kawatani, Yumi Miyaji, Hiroharu Ajiro","doi":"10.1002/chem.202500778","DOIUrl":"https://doi.org/10.1002/chem.202500778","url":null,"abstract":"<p><p>Exploring a reasonable network design to develop highly stretchable hydrogels with over 1,000% extension is still a big challenge in the field of hydrogel chemistry and materials. Micellar copolymerization with hydrophobic monomers and surfactants/proteins is a well-studied approach to provide stretchable hydrogels with hydrophobic association domains as sacrificial bonds when subjected to large deformation, but some limitations, such as dose increase of such monomers and surfactant-free synthesis have not yet been well considered. In this study, we demonstrate a simple but powerful approach to produce transparent, ultra-stretchable hydrogels expressing more than 3,000% elongation by surfactant-free copolymerization of low hydrophobic monomer and amphiphilic monomer. We believe that this result offers wider availability of low hydrophobic groups in various water-containing polymer materials, including gels, micelles, etc.</p>","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e00778"},"PeriodicalIF":3.7,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144787905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
GLY-200, an oral pharmacologic duodenal exclusion drug, resulted in positive effects on glucose, lipids and bodyweight in patients with type 2 diabetes: Results of a randomized, double-blind placebo-controlled trial. GLY-200是一种口服药理学十二指肠排斥药物,对2型糖尿病患者的血糖、血脂和体重有积极影响:一项随机、双盲安慰剂对照试验的结果。
IF 5.7 2区 医学
Diabetes, Obesity & Metabolism Pub Date : 2025-08-06 DOI: 10.1111/dom.16664
Christine L N Bryant, Kevin Colbert, Marcus Hompesch, SuZanne Chaves, Ashish Nimgaonkar, Mark S Fineman
{"title":"GLY-200, an oral pharmacologic duodenal exclusion drug, resulted in positive effects on glucose, lipids and bodyweight in patients with type 2 diabetes: Results of a randomized, double-blind placebo-controlled trial.","authors":"Christine L N Bryant, Kevin Colbert, Marcus Hompesch, SuZanne Chaves, Ashish Nimgaonkar, Mark S Fineman","doi":"10.1111/dom.16664","DOIUrl":"https://doi.org/10.1111/dom.16664","url":null,"abstract":"<p><strong>Aims: </strong>GLY-200 is an investigational oral polymeric drug designed to enhance the barrier function of gastrointestinal mucus as a non-invasive alternative to metabolic surgery. This study evaluated the safety, tolerability and pharmacodynamic effects of GLY-200 in patients with T2D.</p><p><strong>Materials and methods: </strong>This phase 2, placebo (PBO)-controlled, double-blind single-centre inpatient study (ClinicalTrials.gov, NCT05478525) enrolled patients (n = 51) aged 30-70 years with T2D (HbA1c ≥6.0% to <8.5%) on stable metformin ≥750 mg/day for ≥3 months. Patients received 14 days twice a day (BID) of 0.5, 1.0, or 2.0 g GLY-200 or PBO (1:1:1:1). The primary endpoint was safety and tolerability. Additional endpoints included changes in plasma glucose (secondary) and calories and lipid profiles (exploratory).</p><p><strong>Results: </strong>GLY-200 appeared safe and well tolerated. The most frequently related TEAEs in subjects treated with GLY-200 were constipation, nausea, diarrhoea and vomiting, all of which were mild. Improvements in fasting and postprandial glucose were observed. For 2.0 g Day 14 postprandial glucose post-standardized meal, mean absolute AUC<sub>0-3HR</sub> difference from PBO was 178.33 mg/dL*hr (95% CI -327.16 to -29.50; p = 0.02); C<sub>max</sub> difference was 50.88 mg/dL (-100.23 to -1.54; p = 0.04). Day 14 mean change from baseline fasting serum glucose in the 2.0 g group was -16.1 (SD 22.5) versus 12.1 (41.8) mg/dL in the PBO group. GLY-200 treatment also resulted in numerical reductions in food intake, modest decreases in body weight, and improvements in lipid profiles consistent with a duodenal exclusion mechanism.</p><p><strong>Conclusions: </strong>These results suggest duodenal exclusion is possible with an oral polymeric drug and support further development of GLY-200 for the treatment of T2D and obesity.</p>","PeriodicalId":158,"journal":{"name":"Diabetes, Obesity & Metabolism","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144787911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glia Preserve Their Own Functions While Compensating for Neighboring Glial Cell Dysfunction. 神经胶质细胞在补偿邻近神经胶质细胞功能障碍的同时保留自身功能。
IF 5.1 2区 医学
Glia Pub Date : 2025-08-06 DOI: 10.1002/glia.70072
Allison N Beachum, Gabriela Salazar, Amelia Nachbar, Kevin Krause, Hannah Klose, Kate Meyer, Ariana Maserejian, Grace Ross, Hannah Boyd, Thaddeus Weigel, Lydia Ambaye, Hayes Miller, Hannah Grote, Jaeda Coutinho-Budd
{"title":"Glia Preserve Their Own Functions While Compensating for Neighboring Glial Cell Dysfunction.","authors":"Allison N Beachum, Gabriela Salazar, Amelia Nachbar, Kevin Krause, Hannah Klose, Kate Meyer, Ariana Maserejian, Grace Ross, Hannah Boyd, Thaddeus Weigel, Lydia Ambaye, Hayes Miller, Hannah Grote, Jaeda Coutinho-Budd","doi":"10.1002/glia.70072","DOIUrl":"https://doi.org/10.1002/glia.70072","url":null,"abstract":"<p><p>Glial cells are essential for nervous system development, homeostasis, and disease response, engaging in close interactions with neurons and other glial cells to carry out their functions. A large focus of glial studies has been on investigating how these cells work with neurons to execute their supportive roles, yet glial-glial interactions are even less well understood. Our previous work established that the loss of the secreted neurotrophin, Spätzle 3 (Spz3), from Drosophila cortex glia (CG) results in the morphological degradation of CG during mid to late larval development, where they lose their intricate interactions with neurons and other glial subtypes. Building on this work, we found that the loss of CG-neuron interactions triggers aberrant infiltration and functional compensation from all neighboring glial cell types-astrocytes, ensheathing glia (EG), and subperineurial glia (SPG)-and that both the CG disruption and surrounding aberrant glial extensions are inhibited by blocking CNS growth. These aberrant glial processes are able to compensate for at least one major CG function, the clearance of apoptotic neuronal corpses via Draper-mediated engulfment. Remarkably, even as astrocytes, EG, and SPG divert their cellular resources to extend into new territories and take on new functions, they continue to maintain their normal homeostatic roles such as synaptic remodeling (astrocytes), post-injury clearance of neurite debris (ensheathing glia), and regulation of the blood-brain barrier (SPG). These findings reveal that multiple glial subtypes can dynamically respond to nearby glial dysfunction to preserve CNS homeostasis, highlighting the resilience and adaptability of glia across subtypes.</p>","PeriodicalId":174,"journal":{"name":"Glia","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144787914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Green and Sustainable Chemistry Approaches on Azide-Based Click Reactions in Polymer Science. 聚合物科学中叠氮基咔嗒反应的绿色和可持续化学方法。
IF 4.3 3区 化学
Macromolecular Rapid Communications Pub Date : 2025-08-06 DOI: 10.1002/marc.202500171
Hatice Mutlu, Bercis Pektas, C Remzi Becer, Azra Kocaarslan
{"title":"Green and Sustainable Chemistry Approaches on Azide-Based Click Reactions in Polymer Science.","authors":"Hatice Mutlu, Bercis Pektas, C Remzi Becer, Azra Kocaarslan","doi":"10.1002/marc.202500171","DOIUrl":"https://doi.org/10.1002/marc.202500171","url":null,"abstract":"<p><p>Click Chemistry, particularly the azide-alkyne cycloaddition (AAC) reaction, has revolutionized polymer chemistry, enabling precise and efficient synthesis of advanced functional materials. With its high regioselectivity, mild reaction conditions, and versatility, AAC reactions align closely with the principles of Green and Sustainable Chemistry. However, the core principles of Click Chemistry, particularly its compatibility with Green Chemistry ideals-such as reduced waste, high atom economy, and mild reaction conditions-remain insufficiently emphasized in the context of polymer chemistry. The review evaluates current limitations in AAC-particularly the challenges associated with hazardous azide reagents and reliance on non-renewable resources-and explores innovative solutions, including greener catalysts, solvent-free systems, and the incorporation of renewable feedstocks. Additionally, the review presents a comparison of activation methods, spanning thermal, catalytic, metal-free, and strain-promoted pathways, to highlight their respective advantages and trade-offs in sustainability. Practical applications of AAC in polymer design are discussed, showcasing its role in creating materials with tailored properties such as thermal stability, bioactivity, and electronic functionality. This analysis provides a roadmap for future research to optimize AAC for sustainability without compromising its effectiveness in materials design.</p>","PeriodicalId":205,"journal":{"name":"Macromolecular Rapid Communications","volume":" ","pages":"e00171"},"PeriodicalIF":4.3,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144787922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unveiling Twist Domains in Monolayer MoS2 through 4D-STEM and Unsupervised Machine Learning. 通过4D-STEM和无监督机器学习揭示单层MoS2的扭曲域。
IF 9.1 2区 材料科学
Small Methods Pub Date : 2025-08-06 DOI: 10.1002/smtd.202501065
Koji Kimoto, Ovidiu Cretu, Koji Harano, Fumihiko Uesugi, Jun Kikkawa, Kohei Aso, Yoshifumi Oshima, Takashi Matsumoto, Yoshiki Sakuma
{"title":"Unveiling Twist Domains in Monolayer MoS<sub>2</sub> through 4D-STEM and Unsupervised Machine Learning.","authors":"Koji Kimoto, Ovidiu Cretu, Koji Harano, Fumihiko Uesugi, Jun Kikkawa, Kohei Aso, Yoshifumi Oshima, Takashi Matsumoto, Yoshiki Sakuma","doi":"10.1002/smtd.202501065","DOIUrl":"https://doi.org/10.1002/smtd.202501065","url":null,"abstract":"<p><p>Dichalcogenides, such as molybdenum disulfide (MoS<sub>2</sub>), are being studied extensively due to their 2D feature and various material properties. Although crystal structures are critical for applications, conventional atomic structure analyses have a limited field of view. In this study, the crystal domains of monolayer MoS<sub>2</sub> synthesized by metal-organic chemical vapor deposition (MOCVD) are analyzed using 4D scanning transmission electron microscopy (STEM) and unsupervised machine learning. Twist domains (±11°) are identified through the nonnegative matrix factorization (NMF) and hierarchical clustering of numerous (>22k) diffraction patterns from a wide field of view. Preprocessing for detecting noncentrosymmetry effectively visualizes the polarities of distinct MoS<sub>2</sub> domains by highlighting the violation of Friedel's law in diffraction physics. Analyses reveal that the specimen deposited on Al<sub>2</sub>O<sub>3</sub> (0001) at 850 °C consists of domains measuring ≈100 nm in size and featuring many mirror-twin boundaries. The findings provide valuable insights into optimizing the MOCVD process and elucidating crystal growth mechanisms.</p>","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e01065"},"PeriodicalIF":9.1,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144787932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Volcano-Type Behavior in Spatially Resolved Electron Transfer and Hydrogen Evolution Reaction Mapping over 2D Electrocatalysts. 二维电催化剂上空间分辨电子转移和析氢反应映射的火山型行为。
IF 9.1 2区 材料科学
Small Methods Pub Date : 2025-08-06 DOI: 10.1002/smtd.202501169
Septia Kholimatussadiah, Mohammad Qorbani, Yu-Ling Liu, Radha Raman, Ying-Ren Lai, Chih-Yang Huang, Mario Hofmann, Michitoshi Hayashi, Kuei-Hsien Chen, Li-Chyong Chen
{"title":"Volcano-Type Behavior in Spatially Resolved Electron Transfer and Hydrogen Evolution Reaction Mapping over 2D Electrocatalysts.","authors":"Septia Kholimatussadiah, Mohammad Qorbani, Yu-Ling Liu, Radha Raman, Ying-Ren Lai, Chih-Yang Huang, Mario Hofmann, Michitoshi Hayashi, Kuei-Hsien Chen, Li-Chyong Chen","doi":"10.1002/smtd.202501169","DOIUrl":"https://doi.org/10.1002/smtd.202501169","url":null,"abstract":"<p><p>In situ mapping of interfacial electron transfer dynamics to reveal electrocatalytic activity with high spatial resolution is crucial for developing efficient electrochemical devices. While emerging 2D materials for catalysis have attracted substantial attention, there is still a notable lack of studies examining their electrochemical properties at the nanoscale, particularly in a layer-by-layer context. Here, both outer-sphere and inner-sphere electron transfer at a 2D semiconducting WSe<sub>2</sub> electrode-electrolyte interface are spatially resolved and quantified in high resolution. The investigations reveal that WSe<sub>2</sub> exhibits a volcano-type behavior in its electrochemical activity, with a peak performance observed at a specific thickness of four layers. This phenomenon is attributed to the interplay between the layer-specific electronic density of states and the tunneling of charge carriers across the interlayer regions. This observation is further exemplified by micro-electrochemical hydrogen evolution reaction measurements.</p>","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e01169"},"PeriodicalIF":9.1,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144787933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Do Developing Plant Branches Conform to a Single Allometric Growth Rule? 植物分枝发育是否遵循单一异速生长规律?
IF 6.3 1区 生物学
Plant, Cell & Environment Pub Date : 2025-08-06 DOI: 10.1111/pce.70100
Charles A Price, Jacob S Suissa
{"title":"Do Developing Plant Branches Conform to a Single Allometric Growth Rule?","authors":"Charles A Price, Jacob S Suissa","doi":"10.1111/pce.70100","DOIUrl":"https://doi.org/10.1111/pce.70100","url":null,"abstract":"<p><p>The use of physical models to predict patterns of organismal growth has long interested biologists. Models based on hydraulic or biomechanical principles have been invoked to predict the scaling of tree branching networks, but most assume self-similarity throughout the network and don't consider more than a single physical constraint. A more recent model (flow similarity) predicts that the allometry of terminal tree branch dimensions will differ from the bole and basal branches, centering around values derived from hydraulic considerations. Here we evaluate the predictions of the flow similarity model for the growth of terminal stems of woody plants from 52 species sampled across the seed plant phylogeny and spanning over four orders of magnitude in stem volume. We find that the slopes describing terminal stem allometry across seed plants display limited variation, despite nearly 400 million years of divergent evolution across the examined lineages. Phylogenetic analysis reveals stable trait means and a strong pull towards specific values, potentially reflecting stabilising selection. Interestingly, these mean values are largely consistent with the flow similarity model predictions. Our results suggest that the ontogeny of terminal stems in seed plants follow similar allometric scaling principles which operate across evolutionary and ecological scales.</p>","PeriodicalId":222,"journal":{"name":"Plant, Cell & Environment","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Statement on the publication of research with a focus on Indigenous peoples. 关于发表以土著人民为重点的研究报告的声明。
IF 5.3 1区 医学
Addiction Pub Date : 2025-08-06 DOI: 10.1111/add.70167
{"title":"Statement on the publication of research with a focus on Indigenous peoples.","authors":"","doi":"10.1111/add.70167","DOIUrl":"https://doi.org/10.1111/add.70167","url":null,"abstract":"","PeriodicalId":109,"journal":{"name":"Addiction","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144787889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigation on Efficient Coordinated Control of String-Type PV Optimizers Under Irradiation Imbalance 辐照不平衡下串型PV优化器高效协调控制研究
IF 1.9 4区 工程技术
IET Power Electronics Pub Date : 2025-08-06 DOI: 10.1049/pel2.70096
Wenzheng Xu, Yuhao Peng, Jiangang Liang, Ning Chen, Jingdou Liu, Fen Tang
{"title":"Investigation on Efficient Coordinated Control of String-Type PV Optimizers Under Irradiation Imbalance","authors":"Wenzheng Xu,&nbsp;Yuhao Peng,&nbsp;Jiangang Liang,&nbsp;Ning Chen,&nbsp;Jingdou Liu,&nbsp;Fen Tang","doi":"10.1049/pel2.70096","DOIUrl":"https://doi.org/10.1049/pel2.70096","url":null,"abstract":"<p>In grid-connected photovoltaic (PV) systems, string-type PV optimizers can realize maximum power point tracking (MPPT) based on the characteristics of single PV panels under irradiation imbalance, so as to improve the energy utilization rate of PV panels. However, the power loss of the PV optimizers cannot be ignored. Meanwhile, the coordinated start/stop control of PV optimizers with PV inverters deserves further investigation. In this paper, a high-efficiency coordinated control method for grid-connected PV system is proposed. Based on the operating modes and loss of both PV optimizers and inverters, the optimal operating mode of PV optimizers under different irradiation conditions is obtained, especially in case of irradiation imbalance of PV panels. The proposed method also realizes higher reliability and lower power loss in the coordination of the first and second stages of the PV system with the control logic design during the starting, stopping, and fault cases. Experiments are carried out with three 700 W string-type PV optimizers, and the results verify that the proposed method realizes higher conversion efficiency and reliability under different operating cases.</p>","PeriodicalId":56302,"journal":{"name":"IET Power Electronics","volume":"18 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1049/pel2.70096","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144782540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigating Transboundary Spread Patterns and Cluster Characteristics of Lumpy Skin Disease (LSD) Outbreaks in Asia: Levering the Outbreak Data (2019–2023) to Support the LSD Prevention and Control Strategies 调查亚洲肿块性皮肤病(LSD)暴发的跨界传播模式和聚集性特征:利用暴发数据(2019-2023)支持LSD防控策略
IF 3 2区 农林科学
Transboundary and Emerging Diseases Pub Date : 2025-08-06 DOI: 10.1155/tbed/2964021
Veerasak Punyapornwithaya, Supitchaya Srisawang, Orapun Arjkumpa, Waraphon Phimpraphai, Noppawan Buamithup, Bolortuya Purevsuren, Karma Rinzin, Ronello Abila, Ashish Sutar
{"title":"Investigating Transboundary Spread Patterns and Cluster Characteristics of Lumpy Skin Disease (LSD) Outbreaks in Asia: Levering the Outbreak Data (2019–2023) to Support the LSD Prevention and Control Strategies","authors":"Veerasak Punyapornwithaya,&nbsp;Supitchaya Srisawang,&nbsp;Orapun Arjkumpa,&nbsp;Waraphon Phimpraphai,&nbsp;Noppawan Buamithup,&nbsp;Bolortuya Purevsuren,&nbsp;Karma Rinzin,&nbsp;Ronello Abila,&nbsp;Ashish Sutar","doi":"10.1155/tbed/2964021","DOIUrl":"https://doi.org/10.1155/tbed/2964021","url":null,"abstract":"<div>\u0000 <p>Lumpy skin disease (LSD) has rapidly spread across Asia, posing significant threats to livestock industries. This study aims to examine the spatial directional trends and spatiotemporal clusters of LSD outbreaks in South, East, and Southeast Asia from January 2019 to December 2023. Official LSD outbreak data were analyzed using spatial and spatiotemporal models. The standard deviational ellipse (SDE) method was applied to assess directional distribution trends, while space–time permutation (STP) and space–time Poisson models were utilized to identify outbreak clusters. A total of 1385 LSD outbreaks were recorded in the study region during the period. In the Asia region, the directional analysis of all outbreaks revealed trends from the south to the southeast and from the northeast to the southeast, based on the SDE case-weighted and SDE case-unweighted approaches, respectively. Additionally, distinct directional patterns were identified for each subregion. A comparison of the space–time Poisson and STP models showed variations in cluster locations and sizes. The STP model identified primary clusters in India, Bhutan, the Republic of Korea, and Vietnam, whereas the space–time Poisson model highlighted primary clusters in India, Thailand, and Mongolia. Both models detected secondary clusters in various countries including India, Pakistan, Bhutan, China, Mongolia, Nepal, Cambodia, Vietnam, Thailand, Indonesia, Malaysia, Singapore, Sri Lanka, and the Republic of Korea, with the space–time Poisson model identifying larger cluster sizes and the STP model capturing more localized clusters. These findings provide valuable insights into the spatial and temporal dynamics of LSD outbreaks in Asia. The results of this study contribute to a better understanding of LSD epidemiology and offer essential information to support the development of regional and subregional prevention and control strategies.</p>\u0000 </div>","PeriodicalId":234,"journal":{"name":"Transboundary and Emerging Diseases","volume":"2025 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/tbed/2964021","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144782599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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