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{"title":"Ionically Conductive Elastic Polymer Binder for Ultrahigh Loading Electrode in High-Energy-Density Lithium Batteries (Adv. Mater. 42/2025)","authors":"Dong-Yeob Han,&nbsp; Masud,&nbsp;Yeongseok Kim,&nbsp;Saehyun Kim,&nbsp;Dong Gyu Lee,&nbsp;Junhyeok No,&nbsp;Hee Cheul Choi,&nbsp;Tae Kyung Lee,&nbsp;Youn Soo Kim,&nbsp;Soojin Park","doi":"10.1002/adma.70840","DOIUrl":"https://doi.org/10.1002/adma.70840","url":null,"abstract":"<p><b>Ultrahigh Loading Electrode in High-Energy-Density Lithium Batteries</b></p><p>In their Research Article (DOI: 10.1002/adma.202506266), Soojin Park, Youn Soo Kim, and co-workers design an ionically conductive elastic polymer (ICEP) binder that is introduced for fabricating ultrahigh mass-loading NCM811 cathodes, offering enhanced elasticity, adhesion, and ionic conductivity for improved structural and interfacial stability. The cathode, with 62.5 mg cm⁻² (12.7 mAh cm⁻²), delivers 377.6 Wh kg_cell⁻¹/1016.8 Wh L_cell⁻¹ (including packaging) when paired with Li metal anodes, demonstrating excellent electrochemical stability.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"37 42","pages":""},"PeriodicalIF":26.8,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/adma.70840","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145341879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BDNF Loaded Amino Acid-Catecholamine Hybrid Nanoparticles as Curative Agents Against Cognitive Decline in Alzheimer's Disease (Small 42/2025)","authors":"Himanshu Sekhar Panda,&nbsp;Mrunali D. Dhokne,&nbsp;Sumit Thakur,&nbsp;Nisha Singh,&nbsp;Ashok Kumar Datusalia,&nbsp;Jiban Jyoti Panda","doi":"10.1002/smll.70723","DOIUrl":"https://doi.org/10.1002/smll.70723","url":null,"abstract":"<p><b>Alzheimer's Disease</b></p><p>BDNF-loaded amino acid–catecholamine hybrid nanoparticles (B-EDTNPs) are capable of crossing the blood–brain barrier (BBB) to efficiently deliver BDNF. These nanoparticles inhibit Aβ fibrillization, promote amyloid plaque clearance, reduce oxidative stress, and protect neuronal cells from fibril-induced damage. In SH-SY5Y neuroblastoma cells, B-EDTNPs significantly improve cell viability against FF and Aβ (1-42) toxicity. Promising outcomes in AD mouse model are shown by effectively reducing amyloid plaque accumulation, suppress inflammatory markers like NF-κB and TNF-α, and restore cognitive functions. More in article number 2411701, Ashok Kumar Datusalia, Jiban Jyoti Panda, and co-workers.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":228,"journal":{"name":"Small","volume":"21 42","pages":""},"PeriodicalIF":12.1,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/smll.70723","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145341901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ZDHHC2-Dependent Palmitoylation Dictates Ferroptosis and Castration Sensitivity in Prostate Cancer via Controlling ACSL4 Degradation and Lipid Peroxidation.","authors":"Shuai Shao, Wei Li, Yulong Hong, Ruijiang Zeng, Liang Zhu, Lu Yi, Yuan Li, Yinhuai Wang, Haojie Huang, Xuewen Jiang, Xin Jin","doi":"10.1002/advs.202514077","DOIUrl":"https://doi.org/10.1002/advs.202514077","url":null,"abstract":"<p><p>Ferroptosis represents a promising vulnerability to overcome therapeutic resistance in castration-resistant prostate cancer (CRPC). While S-palmitoylation of lipid peroxide-scavenging proteins such as GPX4 and SLC7A11 has been shown to suppress ferroptosis, whether palmitoylation modulates the lipid peroxidation generation remains unclear. Here, we identified the palmitoyltransferase ZDHHC2 as a critical driver of enzalutamide resistance through destabilizing ACSL4. ZDHHC2 is transcriptionally upregulated by a FOXA1/CXXC5/TET2 complex and promotes S-palmitoylation of the deubiquitinase USP19, which impairs its interaction with ACSL4. This disrupts USP19-mediated ACSL4 stabilization, promoting its ubiquitin-proteasome degradation and consequently suppressing lipid peroxidation and ferroptosis. We developed a small-molecule ZDHHC2 inhibitor, TTZ1, which restores ACSL4 protein, reactivates ferroptosis, and reverses enzalutamide resistance in CRPC cell lines and patient-derived xenograft models. This study uncovers a previously unrecognized mechanism by which palmitoylation regulates ferroptosis through modulating ACSL4 stability, and highlights the ZDHHC2-USP19-ACSL4 axis as a druggable target for overcoming resistance in advanced prostate cancer.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e14077"},"PeriodicalIF":14.1,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145342308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Circadian Clock Regulates Receptor-Mediated Immune Responses to a Herbivore-Associated Molecular Pattern.","authors":"Natalia Guayazán Palacios, Takato Imaizumi, Adam D Steinbrenner","doi":"10.1111/pce.70223","DOIUrl":"https://doi.org/10.1111/pce.70223","url":null,"abstract":"<p><p>Plants activate induced defences through the recognition of molecular patterns. Like pathogen-associated molecular patterns, herbivore-associated molecular patterns (HAMPs) can be recognised by cell surface pattern recognition receptors, leading to defensive transcriptional changes in host plants. Herbivore-induced defensive outputs are regulated by the circadian clock, but the underlying molecular mechanisms remain unknown. To investigate how the plant circadian clock regulates transcriptional reprogramming of a specific HAMP-induced pathway, we characterised the daytime and nighttime transcriptional response to the caterpillar-derived HAMP peptide In11 in the legume crop cowpea (Vigna unguiculata). Using diel and free-running conditions, we found that daytime In11 elicitation resulted in stronger late-induced gene expression than nighttime. Plants with a conditional arrhythmic phenotype in constant light conditions lost time-of-day gated responses to In11 treatment, and this was associated with arrhythmic expression of circadian clock core transcription factor Late Elongated Hypocotyl VuLHY1 and VuLHY2. Reporter assays with VuLHY homologues indicated that they interact with the promoter of daytime In11-induced Kunitz Trypsin Inhibitor (VuKTI) via a canonical and a polymorphic CCA1/LHY binding site (CBS), consistent with a mechanism of direct regulation by circadian clock transcription factors. This study improves our understanding of the time-dependent mechanisms that regulate herbivore-induced gene expression.</p>","PeriodicalId":222,"journal":{"name":"Plant, Cell & Environment","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145342311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"London Dispersion versus Intramolecular Hydrogen Bond in Bis-Pyridines: How Accurate Is DFT for Competing Noncovalent Interactions in the Condensed Phase?","authors":"Adélaïde Savoy, Vladimir Gorbachev, Charlotte N Stindt, Peter Chen","doi":"10.1002/chem.202502745","DOIUrl":"https://doi.org/10.1002/chem.202502745","url":null,"abstract":"<p><p>We report a systematic investigation of noncovalent interactions-particularly an intramolecular hydrogen bond and London Dispersion forces-in singly protonated bis-pyridines, studied across solution and crystalline states. Building on our previous gas-phase study, we combine variable-temperature ¹H NMR spectroscopy, single-crystal X-ray diffraction, and density functional theory (DFT) calculations. The measured ¹H NMR chemical shifts of the acidic proton serve as a solution-phase structural readout, which we correlate with an independent crystallographic metric. By systematically varying the linker (-CH₂-, -O-, and -CH₂CH₂-) and the pendant substituents (H, methyl, tert-butyl), we examine how increasingly bulky \"dispersion energy donors\" affect both the intramolecular hydrogen bond and the accessible conformational states. In reference systems, where a single noncovalent interaction governs the geometry, even relatively simple computational models correctly reproduce the experimentally observed structures. However, for molecules featuring two competing noncovalent interactions, the tested, dispersion-corrected, DFT often fails to predict the relative energies of accessible conformers accurately, highlighting current limitations in predictive accuracy. We briefly discuss broader implications of currently achievable predictive accuracy for homogeneous catalysis.</p>","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e02745"},"PeriodicalIF":3.7,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145342321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trigonal Bipyramidal Clusters [Tl₅]^7-: Synthesis and Characterization of the Zintl Phase K_7-xA_xTl₅ (A = Rb, Cs; 0 < x ≤ 2.35).","authors":"Vanessa F Schwinghammer, Tomáš Kovářík, Ilya G Shenderovich, Ján Minár, Stefanie Gärtner","doi":"10.1002/chem.202502837","DOIUrl":"https://doi.org/10.1002/chem.202502837","url":null,"abstract":"<p><p>In alkali metal thallides, a huge variety of thallium clusters can be realized, which are surrounded only by alkali metals. In most cases, different cluster types are present in the crystal structures at the same time. One example is the [Tl₅]^7- trigonal bipyramid, which has only been observed beside [Tl₉]^9-, [Tl₄]^8-, [Tl₃]^7-, [Tl]^5-, or [Tl₈Cd₃]^10-. In the new ternary alkali metal thallide phase K_7-xA_xTl₅ (A = Rb, Cs; 0 < x ≤ 2.35), exclusively [Tl₅]^7- clusters are present, and the compound can be described as a salt-like Zintl-phase, where the electron count is balanced in terms of the anionic moiety and counter cations. This phase crystallizes in the orthorhombic noncentrosymmetric space group Ama2. Different temperature programs applied during synthesis suggested metastability, which was subsequently proven by DSC measurements. DFT calculations reveal a minimum in the DOS at E_F and support the salt-like description. Dissolution experiments in the style of well-known group 14 and group 15 solution chemistry in liquid ammonia were performed and showed oxidation of the alkali metal thallide. Initial ²⁰⁵Tl NMR studies in liquid ammonia allow for the detection of the first signal of a dissolved thallium species emerging from a thallide Zintl phase.</p>","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e02837"},"PeriodicalIF":3.7,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145342343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cover Feature: A Structurally Unique {Fe(NO)2}10-{Fe(NO)2}9 Dinuclear Dinitrosyl Iron Complex Bridged by a μ-ƞ2-FBF3− Ligand and Stabilized by N-Heterocyclic Carbenes","authors":"Yung-Chuan Chuang,&nbsp;Ching-Wen Lin,&nbsp;Yi-Hung Wu,&nbsp;Yu-Hsien Chang,&nbsp;Chung-Hung Hsieh","doi":"10.1002/chem.70299","DOIUrl":"https://doi.org/10.1002/chem.70299","url":null,"abstract":"<p><b>An angelic figure</b> holds a dinuclear dinitrosyl iron complex (DNIC) formed from {Fe(NO)₂}¹⁰ and {Fe(NO)₂}⁹ mononuclear precursors, epitomizing the elegance and precision of this unique molecule. With its rare μ-η²-FBF₃ bridge and stabilization by N-heterocyclic carbenes, like an angel's gentle magic touch, the complex delicately holds and balances redox and structural forces in coordination chemistry, harmonizing electronic and steric finesse. More information can be found in the Research Article by C.-H. Hsieh and co-workers (DOI: 10.1002/chem.202502404).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":"31 59","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/chem.70299","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145341616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formylation of His Residues at Position 2 in Peptide b Ions due to Noncanonical Cα-CO Bond Cleavage: Assignment of the m/z 166 Product Ion in Proteome Data","authors":"Sanjeev Kumar,&nbsp;M. Vijayasarathy,&nbsp;M. A. Venkatesha,&nbsp;P. Balaram","doi":"10.1002/rcm.10154","DOIUrl":"https://doi.org/10.1002/rcm.10154","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Rationale</h3>\u0000 \u0000 <p>The low <i>m/z</i> region (less than 300) in the MS/MS spectra of peptides is rich with product ions arising from neutral losses and noncanonical bond cleavages, resulting from the gas-phase chemistry of low mass <i>b</i>_n/<i>y</i>_n ions containing reactive side chains. This study explores the ion chemistry arising from the presence of His residues at the N-terminus of peptides, focusing on the product ion at <i>m/z</i> 166 often designated as <i>His-related ion</i>.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Tandem mass spectrometry analysis of model His containing synthetic di and tripeptides was carried out on an ion-trap mass spectrometer. Isotope labelling (^<i>13</i><i>C</i>) of the residue(1) CO group permitted monitoring the fate of the labelled carbon atom. A dataset of tryptic peptides containing the <i>m/z</i> 166 ion in their MS/MS spectra was extracted from the consensus human-HCD proteome data available from the NIST database.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>MS/MS analysis of the tripeptide Ala-His-Ala-amide (AHA*), together with isotopically labelled analogs N^α-formyl histidyl ion (fH) amide and synthetic N^α-formyl His amide establishes that the product ion at <i>m/z</i> 166.061 corresponds to the protonated form of the N^α-formyl histidyl ion. Studies with^<i>13</i>C labelled LH amide confirm fH arises by C^α-CO bond cleavage in the XH <i>b</i>₂ ion. Proteomic data analysis confirms that this unusual cleavage is widely observed in tryptic peptides. Examination of the top 500 peptides based on intensity of <i>m/z</i> 166 revealed that the overwhelming majority contain N-terminus XH motifs. Examinations of the top 100 sequences from a dataset of 6064 peptides lacking His that yielded <i>m/z</i> 166 revealed that the majority of 85 sequences arise from AQ <i>b</i>₂ ions by neutral loss of 2NH₃.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In peptide sequences containing N-terminus XH motifs, the histidine imidazole side chain facilitates C^α-CO bond cleavage at residue X.</p>\u0000 </section>\u0000 </div>","PeriodicalId":225,"journal":{"name":"Rapid Communications in Mass Spectrometry","volume":"40 2","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145341818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioinspired Flame-Retardant and Impact-Resistant Aramid Composites via Nacre-Mimetic Self-Assembly for Firefighting Applications (Adv. Mater. 42/2025)","authors":"Zimu Li,&nbsp;Sheng Wang,&nbsp;Liping Gong,&nbsp;Shuai Liu,&nbsp;Wenhui Wang,&nbsp;Jianpeng Wu,&nbsp;Jiahao Li,&nbsp;Weihua Li,&nbsp;Xinglong Gong","doi":"10.1002/adma.70841","DOIUrl":"https://doi.org/10.1002/adma.70841","url":null,"abstract":"<p><b>Firefighting Applications</b></p><p>In their Research Article (DOI: 10.1002/adma.202508606), Sheng Wang, Liping Gong, and co-workers report a nacre-mimetic self-assembly strategy aimed at enhancing the flame and impact resistance of aramid composites. The integration of hydrogen bonding and boron-oxygen crosslinking strengthens interfacial interactions, resulting in mechanical properties that surpass those of many advanced fabrics. This approach holds significant potential for improving fabrics used in firefighting applications.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"37 42","pages":""},"PeriodicalIF":26.8,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/adma.70841","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145341825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cover Feature: Efficient Recovery and Fast Hydrolysis of Polyethylene Terephthalate by Dihydrolevoglucosenone (Cyrene) (ChemSusChem 20/2025)","authors":"Lulu Deng,&nbsp;Hailong He,&nbsp;Zhonghao Chen,&nbsp;Yao Meng,&nbsp;Lei Wang","doi":"10.1002/cssc.70230","DOIUrl":"https://doi.org/10.1002/cssc.70230","url":null,"abstract":"<p><b>The Cover Feature</b> shows a sustainable recycling strategy for poly(ethylene terephthalate) (PET), employing the biobased solvent dihydrolevoglucosenone (Cyrene) both as a dissolution medium and as co-solvent for alkaline hydrolysis. This approach enables efficient PET regeneration and rapid hydrolysis under mild conditions, yielding high-purity PET or terephthalic acid (TPA). More details are available in the Research Article by L. Wang and co-workers (DOI: 10.1002/cssc.202501352).\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":149,"journal":{"name":"ChemSusChem","volume":"18 20","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/cssc.70230","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145341829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}