IF 1.3 4区工程技术

Iet Science Measurement & Technology Pub Date : 2025-08-06 DOI: 10.1049/smt2.70023

Atefeh Tobieha, Neda Behzadfar, Mohammadreza Yousefi, Homayoun Mahdavi-Nasab, Ghazanfar Shahgholian

{"title":"Analysing and Investigating the Effect of Heroin Use Disorder for the Changes of Distinguishing Features in Brain Signal Processing","authors":"Atefeh Tobieha, Neda Behzadfar, Mohammadreza Yousefi, Homayoun Mahdavi-Nasab, Ghazanfar Shahgholian","doi":"10.1049/smt2.70023","DOIUrl":"https://doi.org/10.1049/smt2.70023","url":null,"abstract":"Heroin use disorder alters brain function, leading to significant changes in EEG signals. This study proposes a novel approach to identify distinguishing EEG features in heroin addicts and healthy individuals by integrating frequency and non-frequency domain features. The methodology consists of four main stages: (1) Preprocessing, where EEG signals undergo a 50 Hz notch filter and a Butterworth low-pass filter (0.4–45 Hz) to remove noise and artefacts; (2) Feature Extraction, in which both frequency-domain features (power spectral density in alpha, beta, theta, and delta bands) and non-frequency-domain features (approximate entropy, permutation entropy, wavelet entropy, and fractal dimensions of Katz and Petrosian) are computed; (3) Feature Selection, where the Davies–Bouldin index is employed to determine the most discriminative features, independent of the number of clusters; and (4) Analysis and Interpretation, which highlights that approximate entropy in the Cz channel and power spectral density in the upper alpha band in the O1 channel provide the highest discriminative power. Compared to previous studies that primarily rely on frequency-domain features, this approach captures both linear and nonlinear dynamics of EEG signals, leading to improved differentiation between addicted and healthy individuals. While the method demonstrates high accuracy, its sensitivity to EEG preprocessing and the need for larger datasets remain key considerations. The findings suggest that this framework can contribute to more effective addiction diagnosis and monitoring, with potential integration into machine learning-based EEG classification models.","PeriodicalId":54999,"journal":{"name":"Iet Science Measurement & Technology","volume":"19 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1049/smt2.70023","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144782596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RETRACTION: Design and development of thyroxine/heparin releasing affordable cotton dressings to treat chronic wounds 收缩：设计和开发甲状腺素/肝素释放负担得起的棉质敷料治疗慢性伤口

IF 2.6 3区生物学

Journal of Tissue Engineering and Regenerative Medicine Pub Date : 2025-08-06 DOI: 10.1155/term/9795348

Journal of Tissue Engineering and Regenerative Medicine

{"title":"RETRACTION: Design and development of thyroxine/heparin releasing affordable cotton dressings to treat chronic wounds","authors":"Journal of Tissue Engineering and Regenerative Medicine","doi":"10.1155/term/9795348","DOIUrl":"https://doi.org/10.1155/term/9795348","url":null,"abstract":"RETRACTION: T. S. Waris, S. T. Abbas Shah, A. Mehmood, et al., “Design and development of thyroxine/heparin releasing affordable cotton dressings to treat chronic wounds,” Journal of Tissue Engineering and Regenerative Medicine 2022 (2022): term.3295, https://doi.org/10.1002/term.3295.The above article, published online on 4 March 2022 in Wiley Online Library (https://wileyonlinelibrary.com), has been retracted by agreement between the journal’s Chief Editor Catherine K. Kuo and John Wiley & Sons Ltd.The retraction has been agreed following an investigation of the concerns raised by Mycosphaerella arachidis on PubPeer [1], which identified unexpected similarities between multiple panels of Figure 6(a).More specifically, the images depicting the wounds of animals in the Hep-W and Control-W groups after 20 days appear identical to the image of the T4-W group after 15 days. Further concerns have also been identified related to the similarity of two panels to images shown in Figure 7 from another publication by the author group, where they are attributed to a different experimental condition [2].As a result of the investigation, the data and conclusions of this article are considered unreliable.The authors disagree with this retraction.","PeriodicalId":202,"journal":{"name":"Journal of Tissue Engineering and Regenerative Medicine","volume":"2025 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/term/9795348","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144782597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coastal Hypoxia in the Indian Ocean: Unraveling Drivers of Spatio-Temporal Variability 印度洋沿海缺氧：时空变化的驱动因素

IF 12 1区环境科学与生态学

Global Change Biology Pub Date : 2025-08-06 DOI: 10.1111/gcb.70378

Fan Yang, Laure Resplandy, Yangyang Zhao, Sam Ditkovsky

{"title":"Coastal Hypoxia in the Indian Ocean: Unraveling Drivers of Spatio-Temporal Variability","authors":"Fan Yang, Laure Resplandy, Yangyang Zhao, Sam Ditkovsky","doi":"10.1111/gcb.70378","DOIUrl":"https://doi.org/10.1111/gcb.70378","url":null,"abstract":"Coastal hypoxia in the densely populated Indian Ocean regions has dramatic consequences for ecosystems and ecosystem services such as fisheries and coastal protection. However, inadequate understanding of the spatio-temporal variability of coastal hypoxia in the region, and its physical and biological drivers, poses a major challenge for anticipating these risks. Here we use in-situ observations and a high-resolution (1/12 degree) biophysical model of the Indian Ocean to map areas with heightened vulnerability to coastal hypoxia and identify the drivers of coastal oxygen dynamics. We find strong regional disparities in the mechanisms and temporal scales that govern coastal hypoxia: seasonal upwelling in the eastern Arabian Sea, interannual upwelling/downwelling linked to Indian Ocean Dipole events in the eastern Bay of Bengal, intraseasonal fluctuations introduced by coastal currents, Kelvin waves, and eddies along the western Bay of Bengal, and biologically driven oxygen variations at the mouth of major rivers in the northern Bay of Bengal (e.g., Ganges–Brahmaputra and Irrawaddy–Sittang Deltas). This basin-scale mapping identifies regions where intraseasonal hypoxia (e.g., western Bay of Bengal, river deltas) makes prediction of these events challenging and calls for intense monitoring, and regions where seasonal and interannual hypoxia (e.g., eastern Arabian Sea, eastern Bay of Bengal) facilitates the prevention of the adverse impacts on coastal ecosystems and their services.","PeriodicalId":175,"journal":{"name":"Global Change Biology","volume":"31 8","pages":""},"PeriodicalIF":12.0,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/gcb.70378","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144782784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive Insights into Gel Polymer Electrolytes and Electrode/Electrolyte Interfaces for Aqueous Zinc Ion Batteries. 全面的见解凝胶聚合物电解质和电极/电解质界面的水性锌离子电池。

IF 6.6 2区化学

ChemSusChem Pub Date : 2025-08-06 Epub Date: 2025-07-04 DOI: 10.1002/cssc.202500942

Shuyue Li, Qian Wang, Juan Wang, Heng Jiang, Fei Du

{"title":"Comprehensive Insights into Gel Polymer Electrolytes and Electrode/Electrolyte Interfaces for Aqueous Zinc Ion Batteries.","authors":"Shuyue Li, Qian Wang, Juan Wang, Heng Jiang, Fei Du","doi":"10.1002/cssc.202500942","DOIUrl":"10.1002/cssc.202500942","url":null,"abstract":"Aqueous zinc-ion batteries (AZIBs) have been considered as promising candidates for large-scale energy storage due to environmental friendliness, abundant resources, and high safety. However, aqueous electrolytes suffer from inevitable problems including water splitting, evaporation, and liquid leakage. Gel polymer electrolytes (GPEs), acting as electrolyte and separator simultaneously, can effectively alleviate the challenges of aqueous electrolytes due to hydrogen bonds between hydrophilic polymers and free water molecules. However, GPEs still face serious challenges on the electrode/electrolyte interfaces. Therefore, it is imperative to provide comprehensive insights into recent advances of design principles to optimize electrode/electrolyte interfaces. This review systematically summarizes recent progress of GPEs in AZIBs from the aspects of fundamentals, optimization strategies on electrode/electrolyte interfaces, and applications in detail. First, the fundamentals of GPEs including elaborate classification, synthesis methods, and crucial properties are discussed. Then, the current challenges on the interfaces along with multiple strategies to modulate the interfaces and the practical applications of assembled AZIBs under different conditions are discussed. Finally, this review outlines the opportunities and challenges for obtaining advanced GPEs. This review provides an in-depth understanding of the relationship between properties of electrode/electrolyte interfaces and performances for GPEs, and it is expected to facilitate the development of AZIBs.","PeriodicalId":149,"journal":{"name":"ChemSusChem","volume":" ","pages":"e202500942"},"PeriodicalIF":6.6,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Itaconic Anhydride as a Novel Bio-Derived Solid Electrolyte Interphase Forming Additive for Lithium-Ion Batteries. 衣康酸酐作为一种新型生物来源的锂离子电池固体电解质界面形成添加剂。

IF 6.6 2区化学

ChemSusChem Pub Date : 2025-08-06 Epub Date: 2025-06-30 DOI: 10.1002/cssc.202501134

Metin Orbay, Khai Shin Teoh, Massimo Melchiorre, Christof Neumann, Francesco Ruffo, Andrey Turchanin, Andrea Balducci, Juan Luis Gómez Urbano

{"title":"Itaconic Anhydride as a Novel Bio-Derived Solid Electrolyte Interphase Forming Additive for Lithium-Ion Batteries.","authors":"Metin Orbay, Khai Shin Teoh, Massimo Melchiorre, Christof Neumann, Francesco Ruffo, Andrey Turchanin, Andrea Balducci, Juan Luis Gómez Urbano","doi":"10.1002/cssc.202501134","DOIUrl":"10.1002/cssc.202501134","url":null,"abstract":"In this work, itaconic anhydride (ITC) is introduced as a novel bio-derived additive for lithium-ion batteries. Its ability to create a stable solid electrolyte interphase (SEI) is evaluated in graphite electrodes and compared to vinylene carbonate (VC). The findings show that electrolytes consisting of 1 M lithium bis(trifluoromethanesulfonyl)imide in propylene carbonate and containing ITC and VC additives display similar physicochemical properties. The ability of ITC to form an effective SEI is demonstrated by reversible lithium intercalation during galvanostatic cycling and further corroborated by in situ Raman spectroscopy. Moreover, graphite and lithium iron phosphate (LFP) half-cells display similar electrochemical performance in terms of rate capability and capacity retention along cycling for ITC- and VC-based formulations. ITC undergoes a distinct reduction mechanism on graphite, forming a SEI layer containing C-O and COO- species. Additionally, some insights into the plausible reaction pathways of the reduction byproducts associated with ITC are provided. In sum, this work aims to pave the way toward enhancing the overall sustainability of energy storage devices by exploring a novel bio-based alternative to conventional petrochemical-derived additives.","PeriodicalId":149,"journal":{"name":"ChemSusChem","volume":" ","pages":"e202501134"},"PeriodicalIF":6.6,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Organic Interlayer for Enhanced Buried Interfaces in Wide-Bandgap Perovskite Solar Cells. 宽带隙钙钛矿太阳能电池中增强埋藏界面的有机中间层。

IF 6.6 2区化学

ChemSusChem Pub Date : 2025-08-06 Epub Date: 2025-07-08 DOI: 10.1002/cssc.202500543

JeeHee Hong, Yu Kyung Lee, Seoungyun Shin, Dong Ryeol Whang, Dong Wook Chang, Hui Joon Park

{"title":"Organic Interlayer for Enhanced Buried Interfaces in Wide-Bandgap Perovskite Solar Cells.","authors":"JeeHee Hong, Yu Kyung Lee, Seoungyun Shin, Dong Ryeol Whang, Dong Wook Chang, Hui Joon Park","doi":"10.1002/cssc.202500543","DOIUrl":"10.1002/cssc.202500543","url":null,"abstract":"Achieving high performance and stability in wide-bandgap perovskite solar cells (PSCs) is essential for the development of tandem solar cells capable of surpassing the theoretical efficiency limit of single-junction photovoltaic (PV)devices. However, the performance of wide-bandgap PSCs remains challenging, primarily due to nonradiative recombination at the interfaces. An interlayer applied at the buried interface between the hole transport layer and the perovskite in a p-i-n architecture can play a pivotal role, as it is critical for efficient charge transport, extraction, and the formation of high-quality perovskite films. In this work, a donor-acceptor architectural quinoxaline-based organic interlayer specifically designed for the interface between NiOx and wide-bandgap perovskite is introduced. The incorporation of this interlayer effectively passivates defects at the perovskite interface, leading to improved charge carrier extraction and a substantial reduction in nonradiative recombination, while also enhancing the overall quality of the perovskite film. Moreover, the high dipole moment of QxNN increases the built-in potential of the device, further contributing to enhanced charge extraction. Notably, PSCs incorporating the organic interlayer exhibit a remarkable increase in power conversion efficiency, from 17.5% to 20.0%, while maintaining their performance over 500-h under ambient conditions.","PeriodicalId":149,"journal":{"name":"ChemSusChem","volume":" ","pages":"e202500543"},"PeriodicalIF":6.6,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nitrogen-Functionalized Lignin: Current Status, Applications, and Challenges. 氮功能化木质素：现状、应用和挑战。

IF 6.6 2区化学

ChemSusChem Pub Date : 2025-08-06 Epub Date: 2025-07-09 DOI: 10.1002/cssc.202500607

Jiansong Chen, Kun Liu, Haishun Du, Xuejun Pan

{"title":"Nitrogen-Functionalized Lignin: Current Status, Applications, and Challenges.","authors":"Jiansong Chen, Kun Liu, Haishun Du, Xuejun Pan","doi":"10.1002/cssc.202500607","DOIUrl":"10.1002/cssc.202500607","url":null,"abstract":"Lignin-a natural, abundant, and renewable biopolymer-has garnered increasing attention for its intrinsic sustainability and versatile chemical architecture. The abundance of reactive functional groups within lignin enables its modification to meet specific application requirements. Nitrogen-functionalized lignin (N-lignin), in particular, has emerged as a focal point in contemporary research, providing a pathway to introduce nitrogen functionality through chemical modifications, grafting copolymerization, or physical blending with nitrogen-containing materials. These strategies significantly enhance the performance of the lignin, making it suitable for diverse applications such as catalysts, antifouling agents, nitrogen-enriched fertilizers, and antibacterial materials. This review offers a comprehensive examination of current methodologies for the nitrogen functionalization of lignin. It also delves into the applications of these functionalized materials in diverse fields, including environmental remediation, biomedicine, energy, catalysis, and agriculture. The analysis highlights the potential of N-lignin to drive sustainable innovations while addressing practical challenges, such as scalability, structural heterogeneity, and process optimization. By synthesizing recent advancements and identifying ongoing challenges, this review provides a roadmap for lignin valorization, emphasizing its transformative role in fostering sustainable technologies and materials.","PeriodicalId":149,"journal":{"name":"ChemSusChem","volume":" ","pages":"e202500607"},"PeriodicalIF":6.6,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrathin 2D Ni/Co Hydroxide Heterostructures for High Energy Density Flexible Microsupercapacitor. 高能量密度柔性微型超级电容器的超薄二维Ni/Co氢氧化物异质结构。

IF 6.6 2区化学

ChemSusChem Pub Date : 2025-08-06 Epub Date: 2025-07-09 DOI: 10.1002/cssc.202500850

Sayali Ashok Patil, Pallavi Bhaktapralhad Jagdale, Narad Barman, Amanda Sfeir, Mansi Pathak, Sébastien Royer, Ranjit Thapa, Akshaya Kumar Samal, Manav Saxena

{"title":"Ultrathin 2D Ni/Co Hydroxide Heterostructures for High Energy Density Flexible Microsupercapacitor.","authors":"Sayali Ashok Patil, Pallavi Bhaktapralhad Jagdale, Narad Barman, Amanda Sfeir, Mansi Pathak, Sébastien Royer, Ranjit Thapa, Akshaya Kumar Samal, Manav Saxena","doi":"10.1002/cssc.202500850","DOIUrl":"10.1002/cssc.202500850","url":null,"abstract":"Assembling 2D ultrathin nanosheets into vertical heterostructures offers significant potential for advanced energy storage due to enhanced active sites, improved ion diffusion, and increased electrical conductivity, leading to superior ion/electron transport, higher energy density, and improved rate performance. In case of transition-metal hydroxides, to overcome with challenges such as random assembly, complex synthesis, instability, and poor interfacial contact is critical. This study synthesizes large area, ultrathin, 2D Nickel/Cobalt hydroxide vertical heterostructures (nickel as the top layer) using a wet chemical process, achieving 32% higher areal charge storage compared to cobalt/nickel hydroxide vertical heterostructures, 57% higher than Ni(OH)2 and 330% higher than individual Co(OH)2. The synergistic interaction between nickel and cobalt hydroxides contributes to a high volumetric capacity (710 mAh cm-3) and energy density (285 mAh cm-3) in symmetric devices. The flexible microsupercapacitor retains 75% capacitance after 15,000 cycles and demonstrates stability under bending up to 135°, with a volumetric capacity of 393 mAh cm-3. Density functional theory simulations complement experiments, revealing interaction energy and electronic state redistribution near the Fermi level. This integrated approach serves as a guide for enhancing electrochemical properties in 2D heterostructures, aiding in the development of next-generation, high-performance energy storage materials.","PeriodicalId":149,"journal":{"name":"ChemSusChem","volume":" ","pages":"e202500850"},"PeriodicalIF":6.6,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bombyx Mori Silk Fibroin as a Sustainable Organocatalyst for Diastereoselective Michael Additions. 家蚕丝素蛋白作为非对映选择性Michael添加物的可持续有机催化剂。

IF 6.6 2区化学

ChemSusChem Pub Date : 2025-08-06 Epub Date: 2025-07-14 DOI: 10.1002/cssc.202500584

Carola Ricciardelli, Giorgio Rizzo, Pietro Cotugno, Antonio Salomone, Daniela Trisciuzzi, Orazio Nicolotti, Erica Colaprico, Cosimo D Altomare, Gianluca M Farinola

引用次数: 0

A Metabolite Score of Unintentional Weight Loss Explained a Substantial Proportion of Associated Mortality and Mobility Limitation Risk in a Biracial Older Cohort. 非故意体重减轻的代谢物评分解释了双种族老年队列中相当大比例的相关死亡率和活动受限风险。

IF 7.1 1区医学

Aging Cell Pub Date : 2025-08-06 DOI: 10.1111/acel.70181

Shanshan Yao, Megan M Marron, Samaneh Farsijani, Iva Miljkovic, George C Tseng, Ravi V Shah, Venkatesh L Murthy, Anne B Newman

{"title":"A Metabolite Score of Unintentional Weight Loss Explained a Substantial Proportion of Associated Mortality and Mobility Limitation Risk in a Biracial Older Cohort.","authors":"Shanshan Yao, Megan M Marron, Samaneh Farsijani, Iva Miljkovic, George C Tseng, Ravi V Shah, Venkatesh L Murthy, Anne B Newman","doi":"10.1111/acel.70181","DOIUrl":"https://doi.org/10.1111/acel.70181","url":null,"abstract":"Unintentional weight loss (UWL) is related to mortality and mobility limitation. Here, we aimed to develop a metabolite-based score for UWL and evaluate its prediction performance and explanation value for UWL-related health outcomes. Participants from the Health, Aging and Body Composition (Health ABC) study with available metabolomics and valid follow-ups were included (N = 2286). First, in the derivation group (N = 1200), 27 of the 77 metabolites associated with incident UWL (> 3% annual UWL vs. weight stable) were selected by LASSO-logistic regression. The UWL metabolite score was calculated as a weighted sum of these 27 standardized metabolites, with higher scores indicating greater UWL risk. We then examined the standardized UWL metabolite score against all-cause mortality and incident mobility limitation using Cox regression. Overall, older adults with a one-SD higher UWL metabolite score had higher risks for mortality (1.44 [1.36, 1.52]) and mobility limitation (1.23 [1.15, 1.32]). The score also improved mortality prediction beyond traditional risk factors. Similar results were observed in the hold-out test group (n = 1086). Furthermore, this score explained 28% of the UWL-mortality relationship and 22% of the UWL-mobility limitation relationship beyond lifestyle and medical history, respectively. The score also predicted higher mortality and mobility limitation among those with intentional weight loss and weight gain, demonstrating a good Out-Of-Distribution generalizability. This metabolomic characterization of UWL is predictive of key aging outcomes in the Health ABC participants and captures a substantial portion of the mortality and mobility limitation risks related to unintentional weight loss, further validating the importance of these metabolite signatures.","PeriodicalId":119,"journal":{"name":"Aging Cell","volume":" ","pages":"e70181"},"PeriodicalIF":7.1,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144787896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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