Wiley最新文献

{"title":"Construction of Multifunctional Liquid-Like Coatings: Heterogeneous Interface Regulation Enabling Exceptional Drag Reduction and Repellency Against Multistate Pollutants (Small 42/2025)","authors":"Yongqi Zhang,&nbsp;Jia Man,&nbsp;Guanghui Cui,&nbsp;Zhenhai Zou,&nbsp;Xinzhong Song,&nbsp;Maocheng Ji,&nbsp;Jianyong Li,&nbsp;Jianfeng Li","doi":"10.1002/smll.70719","DOIUrl":"https://doi.org/10.1002/smll.70719","url":null,"abstract":"<p><b>Liquid-Like Coatings</b></p><p>In article number 2506039, Jia Man and co-workers developed a binary liquid-like coating based on dimethyldimethoxysilane and 1H,1H,2H,2H-perfluorooctyldimethylchlorosilane. The coating exhibits high polymer chain flexibility and low surface energy, thereby demonstrating remarkable drag-reducing and anti-fouling capabilities.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":228,"journal":{"name":"Small","volume":"21 42","pages":""},"PeriodicalIF":12.1,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/smll.70719","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145341646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geometrically Tunable Scaffold-Free Muscle Bioconstructs for Treating Volumetric Muscle Loss.","authors":"Bugra Ayan, Gaoxian Chen, Ishita Jain, Sha Chen, Gladys Chiang, Caroline Hu, Renato Reyes, Beu P Oropeza, Ngan F Huang","doi":"10.1002/adhm.202501887","DOIUrl":"https://doi.org/10.1002/adhm.202501887","url":null,"abstract":"<p><p>Traumatic muscle injuries associated with volumetric muscle loss (VML) are characterized by muscle loss beyond intrinsic regeneration capacity, leading to permanent functional impairment. Experimental therapies to augment muscle regeneration, such as cell injection, are limited by low cell transplantation capacity, whereas conventional engineered muscle tissue transplants lack geometric customization to conform to the shape of the muscle defect. Here, a facile approach to engineer scaffold-free high-density muscle tissues in customizable geometric shapes and sizes with high cell viability and integration potential is developed. Using a facile mold-based approach to engineer scaffold-free modular units, transcriptional profiling is performed to uncover the role of pre-formed cell-cell interactions within scaffold-free muscle bioconstructs on myogenesis, an the efficacy of muscle bioconstructs in a mouse model of VML is then evaluated. RNA sequencing revealed that pre-formed cell-cell interactions supported myogenic pathways related to muscle contraction and myofibril assembly, unlike dissociated monodisperse cells. This work further demonstrates the therapeutic efficacy of 3D rectangular solid-shaped scaffold-free transplants in improving muscle function and vascular regeneration. Finally, toward clinical translation, the feasibility of this technology to integrate with medical imaging and artificial intelligence-driven customized bioconstruct design and assembly for intraoperative use is illustrated.</p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e01887"},"PeriodicalIF":9.6,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145342165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine Learning-Driven Grayscale Digital Light Processing for Mechanically Robust 3D-Printed Gradient Materials (Adv. Mater. 42/2025)","authors":"Jisoo Nam,&nbsp;Boxin Chen,&nbsp;Miso Kim","doi":"10.1002/adma.70839","DOIUrl":"https://doi.org/10.1002/adma.70839","url":null,"abstract":"<p><b>Machine Learning-Driven Grayscale Digital Light Processing</b></p><p>In their Research Article (DOI: 10.1002/adma.202504075), Jisoo Nam, Boxin Chen, and Miso Kim combine machine learning-driven optimization with grayscale digital light processing to create 3D-printed gradient materials with tailored mechanical properties. Pixel-level light control enables seamless stiffness modulation, improving stress distribution, toughness, and fatigue life. The cover image illustrates the translation of digital design data into architected gradients for durable, high-performance impact absorbers and protective structures.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"37 42","pages":""},"PeriodicalIF":26.8,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/adma.70839","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145341826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electro-Thermo Cooperative Responsiveness of Cholesteric Heliconical Photonics Architectures Featuring Adaptative Sensitivity (Adv. Mater. 42/2025)","authors":"Conglong Yuan,&nbsp;Huixian Liu,&nbsp;Yuxing Zhan,&nbsp;Xuan Liu,&nbsp;Yuqi Tang,&nbsp;Honglong Hu,&nbsp;Zhi-Gang Zheng,&nbsp;Quan Li","doi":"10.1002/adma.70842","DOIUrl":"https://doi.org/10.1002/adma.70842","url":null,"abstract":"<p><b>Electro-Thermal Cooperative Cholesteric Heliconical Architectures</b></p><p>In their Research Article (DOI: 10.1002/adma.202507000), Zhi-Gang Zheng, Quan Li, and co-workers present electro-thermal cooperative cholesteric heliconical photonic architectures that achieve unprecedented control over thermochromic behavior, enabling linear and programmable temperature sensitivity, full-visible range structural color modulation, and customizable operating ranges. By harnessing these advanced capabilities into intelligent sensing and high-dimensional information encryption, this study paves the way for multi-functional soft matter systems and next-generation photonic technologies.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"37 42","pages":""},"PeriodicalIF":26.8,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/adma.70842","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145341914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic impact of valemetostat in relapsed/refractory adult T-cell leukaemia-lymphoma.","authors":"Takafumi Shichijo, Hiro Tatetsu, Yusuke Higuchi, Toshikazu Miyakawa, Kisato Nosaka, Takahisa Nakamura, Shinya Endo, Asami Yamada, Atsushi Wada, Yuki Okamoto, Toshiro Kawakita, Hitoshi Suzushima, Masao Matsuoka, Jun-Ichirou Yasunaga","doi":"10.1111/bjh.70219","DOIUrl":"https://doi.org/10.1111/bjh.70219","url":null,"abstract":"<p><p>The prognosis for patients with relapsed/refractory (R/R) adult T-cell leukaemia-lymphoma (ATL) remains dismal. Recently, valemetostat, a dual inhibitor for enhancer of zeste homologue (EZH) 1 and 2, was approved in Japan for R/R aggressive ATL. However, there is no real-world data on the efficacy and prognosis of valemetostat. We therefore analysed clinical outcomes in 28 patients with R/R aggressive ATL who received valemetostat at three hospitals in Kumamoto Prefecture between February 2023 and January 2025. The overall response rate (ORR) and complete response (CR) rate were 54.2% and 33.3% respectively. With a median follow-up of 19.2 months (7.3-21.7) for surviving patients, the median survival time was 15.8 months and median progression-free survival (PFS) was 8.3 months. The probabilities of 1-year overall survival (OS) and PFS were 55.8% and 44.1% respectively. Furthermore, the probabilities of 1-year duration of response and duration of CR were 56.2% and 71.4% respectively. Notably, the probability of 1-year OS was 90.9% in patients who achieved CR/partial response (PR) ('responders') compared to 17.0% in patients who did not achieve CR/PR (p < 0.001). Thus, valemetostat has the potential to be a reliable therapy for patients with R/R aggressive ATL, especially for responders.</p>","PeriodicalId":135,"journal":{"name":"British Journal of Haematology","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145342199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Learning Crystallographic Disorder: Bridging Prediction and Experiment in Materials Discovery.","authors":"Konstantin S Jakob, Aron Walsh, Karsten Reuter, Johannes T Margraf","doi":"10.1002/adma.202514226","DOIUrl":"https://doi.org/10.1002/adma.202514226","url":null,"abstract":"<p><p>Recent computational materials discovery efforts have led to an enormous number of predictions of previously unknown, potentially stable inorganic, crystalline compounds. In particular, both high-throughput screenings and generative models have benefited tremendously from recent advances in computational resources and available data. However, these efforts are currently limited to predicting pristine crystalline materials. As a consequence, many of these predictions cannot be realized in experiments, where kinetic effects, defects, and crystallographic disorder can be crucial. To address this shortcoming, the current work aims to introduce disorder into computational materials discovery with machine learning (ML) based classification models. Trained on the inorganic crystal structure database (ICSD), these classifiers capture the chemical trends of crystallographic disorder and estimate the prevalence of disorder in computational databases produced by the Materials Project or Graph Networks for Materials Science (GNoME) initiatives. This opens the door toward disorder-aware computational materials discovery workflows, bridging the gap between prediction and experiment.</p>","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":" ","pages":"e14226"},"PeriodicalIF":26.8,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145342254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lactate-mediated activation of GPR81 regulates BCR/Abl protein expression in chronic myeloid leukemia cells selected under low oxygen tension.","authors":"Giulio Menegazzi, Dayana Desideri, Alessio Biagioni, Elisabetta Rovida, Persio Dello Sbarba, Silvia Peppicelli","doi":"10.1002/path.6492","DOIUrl":"https://doi.org/10.1002/path.6492","url":null,"abstract":"<p><p>Chronic myeloid leukemia (CML) is a stem cell-driven neoplasia characterized by the expression of the constitutively active tyrosine kinase (TK) BCR/Abl. Under low oxygen, a condition that characterizes stem cell niches (SCNs) in vivo, the oncogenic BCR/Abl_protein is suppressed. Consequently, leukemia stem cells (LSCs) residing within SCNs show resistance to TK inhibitors (TKIs), the first-line therapy for CML, due to the lack of their molecular target. It is therefore important to deepen understanding of the mechanisms driving BCR/Abl_protein suppression to design new strategies able to repress TKI-resistant LSCs. Our previous studies showed that BCR/Abl_protein suppression occurred when glucose approaches completed exhaustion in culture medium. As lactate is the main byproduct of glucose catabolism in low oxygen, in this study we addressed the role of lactate in regulating BCR/Abl_protein expression. We found that treatment of CML cells with 2-DG, which blocks glycolysis and thereby lactate production, or monocarboxylate transporter (MCT) inhibitors, which reduce lactate excretion, enhanced BCR/Abl_protein expression and promoted maintenance of a BCR/Abl-dependent/TKI-sensitive stem cell phenotype. The effects of MCT inhibition were abolished when exogenous lactate was added to culture medium, resulting in the suppression of BCR/Abl_protein expression. Treatment with 3-hydroxy-butyrate acid, an antagonist of the GPR81 plasma membrane 'lactate' receptor, prevented lactate-driven BCR/Abl_protein suppression, while the selective GPR81 agonist 3-chloro-5-hydroxy-BA counteracted the maintenance of BCR/Abl_protein induced by MCT inhibition. Our results indicate that GPR81 engagement by extracellular lactate determines BCR/Abl_protein suppression in low oxygen environments. © 2025 The Author(s). The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.</p>","PeriodicalId":232,"journal":{"name":"The Journal of Pathology","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145342403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experiences of Diagnostic Radiography Students With Workplace-Based and Online Learning During the COVID-19 Pandemic: A Study Across Four Higher Education Institutions in South Africa.","authors":"Siyabonga Goodwill Hadebe, Amina Hajat, Lynne Janette Hazell","doi":"10.1002/jmrs.70031","DOIUrl":"https://doi.org/10.1002/jmrs.70031","url":null,"abstract":"<p><strong>Introduction: </strong>The COVID-19 pandemic caught the world by surprise, causing unprecedented disruptions. The training of diagnostic radiography students was particularly affected due to lockdowns and strict regulations. This study aimed to explore and describe diagnostic radiography students' workplace-based and online learning experiences during the COVID-19 pandemic in South Africa.</p><p><strong>Methods: </strong>Using an online open-ended questionnaire, the data were collected from 48 fourth-year diagnostic radiography students in 2023 from the four participating Higher Education Institutions (HEIs) in South Africa. Participants were selected through purposive sampling. Thematic analysis, supported by Atlas.Ti analysis software, was employed to analyse the data.</p><p><strong>Results: </strong>Four key themes were revealed: Theme 1: Clinical placement experiences during COVID-19. Theme 2: Participants' personal protective equipment (PPE) experiences during COVID-19. Theme 3: Participants' experiences of inclusive learning enablers. Theme 4: Impact of COVID-19 lockdowns on learning experiences. Diagnostic radiography students in South Africa faced significant challenges during clinical placements and online learning during the COVID-19 pandemic, including fear, stress, fatigue and emotional exhaustion due to increased workloads. Online learning offered convenience but came with difficulties adapting to new methods and accessing materials, alongside technical issues.</p><p><strong>Conclusion: </strong>The findings highlight diverse experiences among diagnostic radiography students during the pandemic. This research will inform practical recommendations to improve student support during crises, helping them better navigate future similar situations.</p>","PeriodicalId":16382,"journal":{"name":"Journal of Medical Radiation Sciences","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145345692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"KOH-Induced Surface Defluorination and Hydroxylation of CF_X for Ultrahigh Power Density Primary Batteries.","authors":"Ruiping Chen, Yifan Jia, Xiao Feng, Yingxue Yu, Chuxin Wu, Lunhui Guan","doi":"10.1002/cssc.202501826","DOIUrl":"https://doi.org/10.1002/cssc.202501826","url":null,"abstract":"<p><p>Low power capability remains one of the primary challenges for lithium/fluorinated carbon (Li/CF_x) batteries. Surface modification represents a typical strategy for enhancing the intrinsic conductivity and reaction kinetics of CF_x. However, most existing surface modification methods suffer from complex procedures and nonuniform products. To address this problem, this study reports a one-step liquid-phase reaction method, KOH as a defluorination agent, to achieve controlled surface defluorination and -OH grafting on CF_x. The defluorination process reduces edge-inert CF₂/CF₃ groups, exposes CC bonds, and forms an ultrathin, graphene sheet-like conductive coating (≈1 nm thick) on the CF_x surfaces, enhancing lithium-ion and electron transport kinetics during the early discharge stage. Simultaneously, the grafted -OH groups weaken the surrounding CF bonds via hydrogen bonding, increasing the proportion of semi-ionic CF bonds and boosting the electrochemical activity of CF_x. Their synergistic effect significantly improves the reaction kinetics of CF_x during discharge. Relative to pristine CF_x cathodes, batteries using KOH-induced CF_x cathodes achieve a 70C discharge capability, attain 98.42 kW kg^-1 power density, and exhibit near-doubled (95%) improvement in energy density at 50C. This work provides a practical new avenue for large-scale preparation of high-power fluorinated carbon cathodes, facilitating their industrial application.</p>","PeriodicalId":149,"journal":{"name":"ChemSusChem","volume":" ","pages":"e202501826"},"PeriodicalIF":6.6,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145342281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A pH-Responsive Synthetic Receptor for Switchable Binding of Carbohydrates.","authors":"Francesco Milanesi, Giona Corti, Andrea Baldi, Stefano Roelens, Oscar Francesconi","doi":"10.1002/cplu.202500447","DOIUrl":"https://doi.org/10.1002/cplu.202500447","url":null,"abstract":"<p><p>Stimuli-responsive, water-soluble synthetic receptors are key to advancing dynamic molecular recognition in aqueous environments, with implications for self-assembly, molecular machines, and biomedical systems. Herein, a macrocyclic receptor is reported that exhibits pH-dependent binding properties toward saccharides in water, in that it displays markedly different affinities between alkaline and neutral conditions. Spectroscopic and binding studies reveal that the degree of protonation of the solubilizing groups modulates the receptor self-association phenomena, together with concomitant substantial loss of binding ability. This work highlights a rare example of a pH-switchable carbohydrate receptor operating in water and underscores the potentials of such system in the design of smart, responsive molecular architectures.</p>","PeriodicalId":148,"journal":{"name":"ChemPlusChem","volume":" ","pages":"e202500447"},"PeriodicalIF":2.8,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145342249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}