Wiley最新文献

{"title":"GWAS and eQTL analyses reveal genetic components influencing the key fiber yield trait lint percentage in upland cotton","authors":"Chunping Guo,&nbsp;Ruizhen Pi,&nbsp;Yuanlong Wu,&nbsp;Jiaqi You,&nbsp;Zhenyang Qi,&nbsp;Zhenping Liu,&nbsp;Xinyi Chang,&nbsp;Shugen Ding,&nbsp;Qi Zhang,&nbsp;Peng Han,&nbsp;Xianlong Zhang,&nbsp;Chunyuan You,&nbsp;Maojun Wang,&nbsp;Xinhui Nie","doi":"10.1111/tpj.70036","DOIUrl":"https://doi.org/10.1111/tpj.70036","url":null,"abstract":"<div>\u0000 \u0000 <p>Lint percentage is an important component of cotton yield traits and an important economic indicator of cotton production. The initial stage of fiber development is a critical developmental period that affects the lint percentage trait, but the genetic regulation of the initial stage of fiber development needs to be resolved. In this study, we used a genomewide association study (GWAS) to identify 11 quantitative trait loci (QTLs) related to lint percentage and identified a total of 13 859 expression QTL (eQTLs) through transcriptome sequencing of 312 upland cotton accessions. Candidate genes for improving the lint percentage trait were identified through transcriptome-wide association study (TWAS), colocalization analysis, and differentially expressed gene analysis. We located nine candidate genes through the TWAS, and prioritized two key candidate genes (<i>Ghir_A12G025980</i> and <i>Ghir_A12G025990</i>) related to lint percentage through colocalization and differential expression analysis. We showed that two eQTL hotspots (Hot26 and Hot28) synergistically participate in regulating the biological pathways of fiber initiation and development. Additionally, we unlocked the potential of genomic variants in improving the lint percentage by aggregating favorable alleles in accessions. New accessions suitable for improving lint percentage were excavated.</p>\u0000 </div>","PeriodicalId":233,"journal":{"name":"The Plant Journal","volume":"121 5","pages":""},"PeriodicalIF":6.2,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Theoretical Exploration of Ternary Tenoxicam-Alanine-Metal Complexes: An Innovative Avenue Toward Potential Drug Design","authors":"Riaz Maira,&nbsp;Yasmin Tahira,&nbsp;Ahmad Irfan,&nbsp;Muhammad Azam,&nbsp;Muhammad Asim Raza Basra","doi":"10.1002/slct.202405194","DOIUrl":"https://doi.org/10.1002/slct.202405194","url":null,"abstract":"<p>In silico investigation of oxicam, a class of nonsteroidal anti-inflammatory drugs (NSAIDs), and its metal complexes have garnered significant attention due to their therapeutic relevance. Therefore, density functional theory (DFT) has been employed to the mixed complexes of tenoxicam (Ten) and transition metals cobalt (Co), nickel (Ni), iron (Fe), zinc (Zn), and copper (Cu) with alanine (Ala) to obtain influential parameters computationally. B3LYP functional with SDD basis set was used for geometry optimization of each complex. Natural population analysis (NPA) provided the insight into electron density variation across the complexes. The frontier molecular orbitals (FMOs) and energy gap between HOMO and LUMO were analyzed to understand the electronic properties for stability of the complexes. Global reactivity descriptors were calculated to predict the molecular interaction and structure-activity-relationship. Meanwhile ternary metal complexes have been found to be less toxic and more biologically dynamic by computational methods, so they can be employed as compelling drugs for the cure of inflammatory diseases by further in vivo and in silico investigation.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 9","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancement of Environment Friendly Emerging Lead-Free Perovskite Solar Cell Materials and Its Devices","authors":"Ambapuram Meenakshamma,&nbsp;Adike Neeraja,&nbsp;Mitty Raghavender","doi":"10.1002/slct.202405119","DOIUrl":"https://doi.org/10.1002/slct.202405119","url":null,"abstract":"<p>In the advancement of photovoltaic (PV) technology, perovskite solar cells (PSCs) have proven potential in their evolution and have become vanguard research with an extraordinary power conversion efficiency (PCE) performance up to 26%, which stances a remarkable challenge to thin film and multi crystalline silicon (Si) photovoltaic technology. However, the toxicity of lead (Pb), stability issues etc., hampered the commercialization of perovskite solar cells. Scientists have made efforts for the development of different categories of lead-free perovskites, including tin halide perovskites, germanium-based perovskites, and heterovalent elements (Transition metal halide perovskite, double perovskites etc.). However, the performance of the corresponding devices is not up to the mark, and there are stability issues. The limitations mainly initiate from either the unstable lattice structure of these materials or their low dimensionality (e.g., structural and electronic dimensionality)-related to poor carrier transport and self-trapping effect, accelerating nonradiative recombination. This article reviews the environmentally friendly PSCs developed by the use of novel, low/nontoxic perovskite materials, with specific attention focused on assets of identical perovskites and pertinent production of high efficiency PV devices, notable achievement reports of all lead-free perovskites to date with PV performance, and stability of corresponding devices, photovoltaic applications and their commercialization.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 9","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging of Uncommon Chronic Mastitis From S. gallolyticus and S. chromogenes in a Smallholder Dairy Farm in Cambodia","authors":"Nouv Sophorn,&nbsp;Na Sambo,&nbsp;Satoshi Ohkura,&nbsp;Sho Nakamura,&nbsp;Shuichi Matsuyama,&nbsp;Tetsuma Murase,&nbsp;Rin Soriya,&nbsp;Witaya Suriyasathaporn","doi":"10.1155/tbed/3621605","DOIUrl":"https://doi.org/10.1155/tbed/3621605","url":null,"abstract":"<div>\u0000 <p>The complete mastitis control program is insufficient for the starting dairy industry country, and therefore it might cause emerging of new mastitis pathogens. This longitudinal study aimed to determine the association of the infected dynamic status of the main pathogens responsible for mastitis with seasonal variations, the proportions of transient and chronic intramammary infection (IMI) episodes, and the duration of IMI. This study was conducted on a training smallholder dairy farm in Phnom Penh, Cambodia, from January 2023 to July 2023. Trained veterinarians aseptically collected quarter milk samples from all milking cows (<i>n</i> = 21) every 2 weeks until the end of the study, accounting for 3–16 times of milk collection per cow based on their period of lactation. All collected milk samples (<i>n</i> = 812) were cultured, and subsequently, all bacterial colonies were identified using a MALDI-TOF mass spectrometer. An IMI episode is defined as a sequence of consecutive isolates of a specific bacterium from the same quarter. The duration of an episode is the time between the new IMI and its cure. Two types of IMI were defined as transient IMI and chronic IMI that lasted for 28 days or more. Results of the IMI episodes, distributions of no, single, double-mixed, and 3-mixed IMI were 61.1%, 31.9%, 6.3%, and 0.7%, respectively, in which the mixed IMI accounts for 18% of IMI samples. <i>Streptococcus uberis</i>, <i>Staphylococcus chromogenes</i>, and <i>Streptococcus gallolyticus</i> were the main organisms responsible for the mastitis epidemic on this farm. These bacteria had higher ratios of chronic episodes than the other mastitis bacteria found on this farm. In addition, results obtained from Cox’s model showed that <i>S. chromogenes</i> had a longer time to cure than pathogens other than <i>S. uberis</i> and <i>S. gallolyticus</i>, in which <i>S. gallolyticus</i> linked to colon neoplasia in humans. In conclusion, the lack of an optimal mastitis control program, in this case, provides information on the emerging mixed infections, emerging mastitis pathogens, and emerging chronic <i>S. chromogenes</i> infections.</p>\u0000 </div>","PeriodicalId":234,"journal":{"name":"Transboundary and Emerging Diseases","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/tbed/3621605","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cover Feature: Ultrafast ppb-Level Detection of Nitro-Furan Based Antibiotics in Aqueous Medium by an Oxadiazole-Grafted Luminescent Sensor (Chem. Asian J. 5/2025)","authors":"Alokananda Chanda,&nbsp;Sanjay K. Mandal","doi":"10.1002/asia.202580502","DOIUrl":"https://doi.org/10.1002/asia.202580502","url":null,"abstract":"<p>This cover feature represents the research for the utilization of a Zn-based 2D MOF in selective detection of nitrofuran-based antibiotics, such as nitrofurantoin and nitrofurazone, in aqueous medium in ppb level. These analytes interact with the 2D MOF through hydrogen bonding and p-p interactions. The 2D MOF can also efficiently detect the presence of Martifur-100 tablet, which has nitrofurantoin as one of the active ingredients, in aqueous medium. More details can be found in article number e202401206 by Alokananda Chanda and Sanjay K. Mandal.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":"20 5","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/asia.202580502","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: “Prevalence and Influencing Factors of Malnutrition in Diabetic Patients: A Systematic Review and Meta-Analysis”","authors":"Shubham Kumar,&nbsp;Nosaibah Razaqi,&nbsp;Rachana Mehta,&nbsp;Ranjana Sah","doi":"10.1111/1753-0407.70067","DOIUrl":"https://doi.org/10.1111/1753-0407.70067","url":null,"abstract":"&lt;p&gt;We read with great interest the recent article by Zhang et al., titled “Prevalence and influencing factors of malnutrition in diabetic patients: A systematic review and meta-analysis” [&lt;span&gt;1&lt;/span&gt;]. The study provides valuable insights into an important area of clinical nutrition. The authors should be commended for their effort in consolidating data on malnutrition in diabetic patients and highlighting its associated risk factors. However, upon a detailed review of the article, several methodological issues and potential areas for improvement were identified, which could enhance the reliability and clinical applicability of their findings.&lt;/p&gt;&lt;p&gt;One significant limitation lies in the presence of substantial heterogeneity across the included studies, as evidenced by high &lt;i&gt;I&lt;/i&gt;&lt;sup&gt;2&lt;/sup&gt; values (&gt; 90%). The heterogeneity raises concerns regarding the comparability of pooled prevalence estimates for malnutrition and at-risk malnutrition, which the authors reported as 33% and 44%, respectively. Although the authors performed subgroup analyses by measurement tools, region, and diabetes complications, these analyses did not fully address the underlying causes of variability. The authors could have considered using meta-regression analysis to explore potential sources of heterogeneity, such as differences in study design, sample characteristics, and diagnostic criteria [&lt;span&gt;2&lt;/span&gt;]. This statistical approach would have provided a deeper understanding of the heterogeneity and potentially improved the robustness of their conclusions.&lt;/p&gt;&lt;p&gt;Additionally, the authors relied on confidence intervals (CIs) to present pooled estimates but did not include prediction intervals (PIs). While CIs describe the precision of the pooled effect size, PIs would have conveyed the range of effects expected in future studies. The use of PIs is especially critical in the presence of high heterogeneity, as it offers a clearer picture of the variability across different settings and populations [&lt;span&gt;3&lt;/span&gt;]. The inclusion of PIs alongside CIs would have strengthened the interpretation of the meta-analysis results, particularly for clinical decision-making.&lt;/p&gt;&lt;p&gt;Another important methodological concern involves the assessment of publication bias. The authors used Egger's test and visual inspection of funnel plots to evaluate publication bias. While these methods are widely used, they may not be optimal for meta-analyses involving proportions, where asymmetry in funnel plots can arise from true heterogeneity rather than bias. The authors might have instead employed more appropriate approaches, such as the Doi plot and LFK index, which are specifically designed to assess publication bias in proportion meta-analyses [&lt;span&gt;4&lt;/span&gt;]. These methods offer greater reliability in detecting bias in prevalence studies and could have provided additional assurance regarding the integrity of the findings.&lt;/p&gt;&lt;p&gt;The use of diverse diagnostic tools, such as the Mini Nu","PeriodicalId":189,"journal":{"name":"Journal of Diabetes","volume":"17 3","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1753-0407.70067","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linking Metastatic Potential and Viscoelastic Properties of Breast Cancer Spheroids via Dynamic Compression and Relaxation in Microfluidics (Adv. Healthcare Mater. 6/2025)","authors":"Margherita Tavasso,&nbsp;Ankur D. Bordoloi,&nbsp;Elsa Tanré,&nbsp;Sanne A. H. Dekker,&nbsp;Valeria Garbin,&nbsp;Pouyan E. Boukany","doi":"10.1002/adhm.202570036","DOIUrl":"https://doi.org/10.1002/adhm.202570036","url":null,"abstract":"<p><b>Viscoelastic Properties of Breast Cancer Spheroids</b></p><p>In article 2402715, Ankur D. Bordoloi, Pouyan E. Boukany, and co-workers link the viscoelastic properties of breast cancer spheroids to their metastatic potential. In a constricted microfluidic device, benign spheroids are found to be more elastic and viscous than malignant ones, with differences in their relaxation times, morphology, and cytoskeletal organization.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"14 6","pages":""},"PeriodicalIF":10.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adhm.202570036","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protein Nanoparticles for Targeted SARS-CoV-2 Trapping and Neutralization (Adv. Healthcare Mater. 6/2025)","authors":"Marc Fornt-Suñé,&nbsp;Maria C. Puertas,&nbsp;Javier Martinez-Picado,&nbsp;Javier García-Pardo,&nbsp;Salvador Ventura","doi":"10.1002/adhm.202570033","DOIUrl":"https://doi.org/10.1002/adhm.202570033","url":null,"abstract":"<p><b>Protein Nanoparticles Neutralize SARS-CoV-2</b></p><p>In article 2402744, Javier García-Pardo, Salvador Ventura, and co-workers introduce fluorescent protein-only nanoparticles engineered to neutralize SARS-CoV-2 by specifically targeting its spike protein. These cost-effective and easily scalable nanostructures exhibit high affinity for the spike receptor-binding domain, effectively blocking viral entry into human cells. Their versatility positions them as candidates for antiviral applications, including surface functionalization and the development of efficient virus-capturing devices.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"14 6","pages":""},"PeriodicalIF":10.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adhm.202570033","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Plaque Characteristics With New Ischemic Lesions After Carotid Artery Stenting","authors":"Senhao Zhang,&nbsp;Mengmeng Feng,&nbsp;Fan Yu,&nbsp;Xin Meng,&nbsp;Yue Zhang,&nbsp;Bixiao Cui,&nbsp;Tao Wang,&nbsp;Weizhao Lu,&nbsp;Hongwei Yang,&nbsp;Shaozhen Yan,&nbsp;Jie Lu","doi":"10.1111/cns.70312","DOIUrl":"https://doi.org/10.1111/cns.70312","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Carotid artery stenting (CAS) is a common treatment for carotid artery stenosis, but it can lead to new ischemic brain lesions on diffusion-weighted images (DWI) during the perioperative period. Identifying these lesions early is crucial to preventing recurrent ischemic strokes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective study included 47 patients who underwent CAS. Preoperative carotid PET/MR examinations and postoperative brain MRI were performed. Clinicians identified the responsible carotid artery based on symptoms and records. Vessel morphology, plaque characteristics, and inflammatory uptake were analyzed. The standardized uptake value and tissue-to-background ratio quantified ¹⁸F-fluorodeoxyglucose(¹⁸F-FDG) uptake. The symptomatic carotid atheroma inflammation lumen-stenosis(SCAIL) score assessed stenosis severity and inflammation. The primary outcome was the presence of new ischemic lesions on DWI.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among the 47 patients (mean age, 65 ± 7 years; 44 males), 30 (63.8%) exhibited new ischemic lesions. These patients had a higher prevalence of AHA type VI plaques (50.0% vs. 17.6%, <i>p</i> = 0.028), higher PET uptake (43.3% vs. 11.8%, <i>p</i> = 0.026), and higher SCAIL scores (63.3% vs. 23.5%, <i>p</i> = 0.009). The most common distribution pattern of new ischemic lesions was located in the mixed (in and beyond of the treated artery) territory (36.2%). Of the 30 participants with new ischemic lesions, 15 (50%) had lesions located in both peripheral brain areas and deep brain areas. In the adjusted model, high PET uptake and SCAIL scores were independently associated with new ischemic lesions (aOR = 7.26, 95% CI: 1.22, 73.59; <i>p</i> = 0.049 and aOR = 7.06 [95% CI: 1.50, 44.18]; <i>p</i> = 0.020).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Carotid PET/MR-related indicators can effectively predict the risk of new ischemic lesions on DWI during the perioperative period after carotid artery stenting, providing important references for early identification of high-risk patients for recurrent ischemic stroke. Further large-scale randomized controlled studies are necessary to validate the clinical application value of these indicators.</p>\u0000 </section>\u0000 </div>","PeriodicalId":154,"journal":{"name":"CNS Neuroscience & Therapeutics","volume":"31 3","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cns.70312","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Future of Metal-Based Anticancer Agents: A Comprehensive Review of Ruthenium-Based Complexes","authors":"Sanyukta Bhattacharya,&nbsp;Tenzin Adon,&nbsp;Karen Dsouza,&nbsp;Honnavalli Yogish Kumar","doi":"10.1002/slct.202404147","DOIUrl":"https://doi.org/10.1002/slct.202404147","url":null,"abstract":"<p>Ruthenium complexes are gaining recognition in oncology as promising alternatives to the traditionally used platinum-based anticancer agents. Unlike Pt agents, they can better differentiate between healthy and malignant cells, minimizing adverse side effects. They exhibit advantageous properties such as thermodynamic and kinetic stability, increased water solubility, enhanced cellular absorption, superior selectivity and cytotoxicity for tumors, and decreased toxicity to healthy cells. Ruthenium has been used to make complexes having structural variability and the ability to undergo ligand exchange. Ruthenium complexes are effective against metastatic tumor cells and can interact with cellular components; their significant charges and large cavities allow efficient molecule encapsulation. These complexes are being explored to enhance their efficacy in enzymatic research and targeted therapies. The manifold biochemical properties of ruthenium complexes and their ability to induce tumor cell apoptosis through various signaling pathways make them promising candidates for future anticancer agents. Despite successful testing of some of these complexes in clinical trials, none have been commercially available. Continued research aims to unlock the full potential of ruthenium complexes in cancer treatment. This review covers a few research findings of the past 6 years on the potential of ruthenium complexes ligated with organic moieties as antineoplastic agents.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 9","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}