ACS Infectious Diseases最新文献_第9页

Comparative Phenotypic Screening Identifies Protein Synthesis Inhibitors as Compounds That Enhance Early Acidification of Mycobacterium tuberculosis in Macrophages 比较表型筛选鉴定蛋白质合成抑制剂是增强巨噬细胞中结核分枝杆菌早期酸化的化合物。

IF 4.5 2区医学

ACS Infectious Diseases Pub Date : 2026-08-14 Epub Date: 2026-07-01 DOI: 10.1021/acsinfecdis.6c00093

Leah Rankine-Wilson, Yossef Av-Gay

{"title":"Comparative Phenotypic Screening Identifies Protein Synthesis Inhibitors as Compounds That Enhance Early Acidification of Mycobacterium tuberculosis in Macrophages","authors":"Leah Rankine-Wilson, Yossef Av-Gay","doi":"10.1021/acsinfecdis.6c00093","DOIUrl":"10.1021/acsinfecdis.6c00093","url":null,"abstract":"Treatments for tuberculosis disease (TB) are failingon a globalscale, necessitating new drug discovery efforts to identify effectivetherapies. Mycobacterium tuberculosis (Mtb), the obligate human pathogen and causative agent of TB, resideswithin alveolar macrophages and combats acidic stress by inhibitingphagosome maturation. Understanding the role of acidification in Mtbpathogenesis can aid the development of improved TB therapies. Aligningwith the hypothesis that acidification affects Mtb intracellular survival,we developed a phenotypic assay to identify compounds that enhanceacidification of Mtb in infected macrophages. To evaluate the assaysuitability for screening purposes, we screened two compound librariesand found that early acidification does not necessarily correlatewith inhibition of Mtb growth over time. Further, we found that compoundsinterfering with bacterial protein and DNA synthesis induced earlyphagosome acidification. However, other compounds, including cellwall synthesis inhibitors, did not consistently correlate with acidificationor growth inhibition. Using early acidification could therefore providea potential avenue to inform antimicrobial kinetics. By assessingMtb’s response to phagosome acidification, this work highlightsthe complexity of host–pathogen interactions in early infectionand provides a valuable tool for investigating Mtb survival mechanismsand accelerating drug discovery efforts.","PeriodicalId":17,"journal":{"name":"ACS Infectious Diseases","volume":"12 8","pages":"2650–2662"},"PeriodicalIF":4.5,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148358351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Vivo Activity of Antimicrobial Peptoid Oligomers against HSV-1 in a Mouse Model of Herpes Labialis 抗菌肽低聚物在小鼠唇疱疹模型中抗HSV-1的体内活性

IF 4.5 2区医学

ACS Infectious Diseases Pub Date : 2026-08-14 Epub Date: 2026-07-05 DOI: 10.1021/acsinfecdis.6c00224

Erika L. Figgins, Denny Gao, Lisa K. Ryan, Jennifer S. Lin, Natalia Molchanova, Edward M. Rudnic, Sheetal Vali, Brian S. Shumway, Kent Kirshenbaum, Annelise E. Barron, Gill Diamond

{"title":"In Vivo Activity of Antimicrobial Peptoid Oligomers against HSV-1 in a Mouse Model of Herpes Labialis","authors":"Erika L. Figgins, Denny Gao, Lisa K. Ryan, Jennifer S. Lin, Natalia Molchanova, Edward M. Rudnic, Sheetal Vali, Brian S. Shumway, Kent Kirshenbaum, Annelise E. Barron, Gill Diamond","doi":"10.1021/acsinfecdis.6c00224","DOIUrl":"10.1021/acsinfecdis.6c00224","url":null,"abstract":"Herpes simplex virustype-1 (HSV-1) infections cause recurrentoral lesions and are the primary cause of infectious blindness andgenital lesions in developed countries. HSV-1 can also lead to life-threateninginfections in immunocompromised individuals. Currently, the primaryclass of antiviral therapeutics for HSV-1 treatment are nucleosideanalogues such as acyclovir. However, these therapeutics are onlypartially effective and are subject to development of resistance.Thus, the development of new, effective antiviral agents, which canbe used topically to inactivate HSV-1, is a necessity. We have recentlydemonstrated the potent antiviral activity of a family of biomimeticcompounds. These ‘peptoid’ (N-substitutedglycine) oligomers mimic the structure and activity of antimicrobialpeptides like LL-37, while being highly resistant to proteases. Antiviralpeptoids rapidly inactivate HSV-1 in vitro by disruptionof the viral envelope, likely through interaction with the lipid phosphatidylserineon the outer membrane leaflet. To test the in vivo activity of these peptoids, we optimized a lip treatment model ofHSV-1 infection. We demonstrate that delivery of a clinical isolateof HSV-1, strain 294.1, onto scarified lips of BALB/c mice led toreproducible lesions within 5 days. Treatment of these lesions onday 2 post infection with increasing concentrations of an antiviralpeptoid resulted in a dose-dependent inhibition of lesion formation,comparable to acyclovir cream, and the host defense peptide LL-37.The same dose-dependence was observed when quantifying viral DNA fromboth the lip and the trigeminal ganglion by qPCR. The results demonstratethe ability of these peptoids to be developed as topical antiviralagents to prevent herpes labialis infections caused by HSV-1.","PeriodicalId":17,"journal":{"name":"ACS Infectious Diseases","volume":"12 8","pages":"2703–2712"},"PeriodicalIF":4.5,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148389405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to “Peptide Dendrimer-Based Antibacterial Agents: Synthesis and Applications” 对“基于多肽树突的抗菌剂：合成与应用”的更正。

IF 4.5 2区医学

ACS Infectious Diseases Pub Date : 2026-08-14 Epub Date: 2026-07-14 DOI: 10.1021/acsinfecdis.6c00594

Suchita Paul, Sandeep Verma, Yu-Chie Chen

引用次数: 0

Strathclyde Minor Groove Binders Bearing Amidine Tail Groups are Effective against Gram-Positive Bacterial Pathogens 含有脒尾基团的Strathclyde小凹槽粘结剂对革兰氏阳性细菌病原体有效。

IF 4.5 2区医学

ACS Infectious Diseases Pub Date : 2026-08-14 Epub Date: 2026-07-14 DOI: 10.1021/acsinfecdis.6c00443

Charlotte K. Hind, Kaveh Eskandari, Leah M. C. McGee, Rebecca Beveridge, Louise C. Young, Edward Hutchings, Matthew E. Wand, Melanie Clifford, J. Mark Sutton, Fraser J. Scott

{"title":"Strathclyde Minor Groove Binders Bearing Amidine Tail Groups are Effective against Gram-Positive Bacterial Pathogens","authors":"Charlotte K. Hind, Kaveh Eskandari, Leah M. C. McGee, Rebecca Beveridge, Louise C. Young, Edward Hutchings, Matthew E. Wand, Melanie Clifford, J. Mark Sutton, Fraser J. Scott","doi":"10.1021/acsinfecdis.6c00443","DOIUrl":"10.1021/acsinfecdis.6c00443","url":null,"abstract":"The rise of multidrug-resistant Gram-positive pathogensnecessitatesnew antibacterial agents with mechanisms that are distinct from thoseof existing therapies. Here, we report the antibacterial activityand mechanistic characterization of two Strathclyde minor groove binders(S-MGBs), S-MGB-234 and S-MGB-235, synthetic DNA binding moleculesdesigned to disrupt essential bacterial processes. These compoundsdisplayed potent in vitro activity against clinically relevant Gram-positivepathogens, including Staphylococcus aureus and Enterococcusspp. However, potencywas less pronounced against Enterococcus faecalis. Activity was retained against drug-resistant strains, and reducedsusceptibility emerged more slowly during serial passaging than thatobserved for gentamicin under the conditions tested. Whole-genomesequencing of reduced susceptibility mutants did not identify mutationsin canonical DNA targets but instead revealed recurring changes ingenes associated with the cell envelope, including norA, fmtA, andcozEb, suggesting that envelope-mediated effects influence compoundaccess rather than direct target modification. Biophysical assaysdemonstrate strong interactions with AT-rich oligonucleotides andgDNA, consistent with the DNA binding properties previously reportedfor the S-MGB class. Together, these findings demonstrate that S-MGBsrepresent a promising class of DNA-targeting antibacterials and provideinitial evidence that reduced susceptibility emerges through heterogeneousmechanisms that do not involve obvious modifications of DNA targets.","PeriodicalId":17,"journal":{"name":"ACS Infectious Diseases","volume":"12 8","pages":"2825–2837"},"PeriodicalIF":4.5,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148443490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Random Forest Modeling to Predict Small Molecule Accumulation in Gram-Negative Bacteria 随机森林模型预测革兰氏阴性菌的小分子积累。

IF 4.5 2区医学

ACS Infectious Diseases Pub Date : 2026-08-14 Epub Date: 2026-07-18 DOI: 10.1021/acsinfecdis.6c00421

Blake R. Levy, Paul J. Hergenrother

{"title":"Random Forest Modeling to Predict Small Molecule Accumulation in Gram-Negative Bacteria","authors":"Blake R. Levy, Paul J. Hergenrother","doi":"10.1021/acsinfecdis.6c00421","DOIUrl":"10.1021/acsinfecdis.6c00421","url":null,"abstract":"Despite extensive efforts over the past ∼60 yearsto discovernew classes of Gram-negative-active antibiotics, the development pipelineremains relatively dry. These failures can be largely ascribed tothe complexity of the Gram-negative membranes and an inadequate understandingof physicochemical properties associated with compound permeation,efflux evasion, and overall accumulation in Gram-negative pathogens.Recent work using unbiased accumulation assays and advanced chemicaldescriptors has utilized machine learning algorithms, particularlyrandom forest modeling, to correlate physicochemical properties ofsmall molecules with accumulation. The ability of a random forestclassifier to effectively process large data sets while still providinghuman-interpretable insight makes this model a valuable tool in accumulationdata analysis. Here, we describe in detail a workflow reliant on randomforest modeling to probe physicochemical trends linked to small moleculepermeation and/or efflux liabilities in Gram-negative pathogens. Applicationsusing random forest modeling have led to guidelines for small moleculeaccumulation in E. coli and P. aeruginosa that have resulted in multiple newGram-negative-active antibiotics. Random forest modeling possessesseveral distinct advantages over other machine learning models forthe purposes of identifying physicochemical trends in accumulation,and as such, provides valuable hypothesis-generating information forthe study of small molecule accumulation in Gram-negative bacteria.","PeriodicalId":17,"journal":{"name":"ACS Infectious Diseases","volume":"12 8","pages":"2558–2571"},"PeriodicalIF":4.5,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148496847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biophysical Elucidation of the Distinct Roles the Nipah Virus Attachment and Fusion Glycoproteins Play in the Entry Process 尼帕病毒附着和融合糖蛋白在进入过程中不同作用的生物物理阐明。

IF 4.5 2区医学

ACS Infectious Diseases Pub Date : 2026-08-14 Epub Date: 2026-07-23 DOI: 10.1021/acsinfecdis.5c00374

Sreetama Pal, Hector C. Aguilar, Susan Daniel

{"title":"Biophysical Elucidation of the Distinct Roles the Nipah Virus Attachment and Fusion Glycoproteins Play in the Entry Process","authors":"Sreetama Pal, Hector C. Aguilar, Susan Daniel","doi":"10.1021/acsinfecdis.5c00374","DOIUrl":"10.1021/acsinfecdis.5c00374","url":null,"abstract":"Nipah virus (NiV), a World Health Organization prioritypathogen,is a lethal enveloped RNA virus within the Paramyxoviridae family. NiV attachment G and fusion F glycoproteins execute viral-cellor cell–cell membrane fusion during viral entry and syncytiaformation, respectively. Despite past studies, several aspects ofthe molecular-level orchestration underlying this process, such ashow F, G, and their interactions regulate fusion, remain poorly understood,obscured by challenges in decoupling fusion determinants in complexcellular environments. Here, we report a reconstitution-based approachfor mimicking the NiV-host interface, employing virus-like particleswith NiV M, F, and/or G proteins and plasma membrane vesicles derivedfrom NiV-permissive host cells. We found this minimal system can accuratelyrecapitulate NiV-host cell fusion, and used this platform for biophysicaldissection of NiV fusion using wild-type or mutant F and G proteinsaffecting fusion at distinct intermediate steps. We show that F andG affect hemifusion and pore formation stages of NiV fusion in distinctways, revealing a tightly regulated fusion landscape. Our approachalso delivers one of the first direct measurementsof temperature thresholds for NiV fusion, providing novel insightsinto energetic requirements underlying viral fusogenicity. These findingsdemonstrate the power of this approach in dissecting aspects of NiVfusion not accessible via cell-based assays. Thus, this study servesas a blueprint for comprehensive fusion analysis of other viruseswith multicomponent fusion machinery and host protein receptors, andcould be repurposed into therapeutic screening platforms targetingtheir fusion mechanisms, necessary for developing novel antivirals.","PeriodicalId":17,"journal":{"name":"ACS Infectious Diseases","volume":"12 8","pages":"2601–2613"},"PeriodicalIF":4.5,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148560187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Multiplex CRISPR-Cas12a-Based Hydrogel Microarray Platform for the Simultaneous Detection of Common Adenovirus Types in Clinical Samples 基于多重crispr - cas12的水凝胶微阵列平台用于临床样品中常见腺病毒类型的同时检测

IF 4.5 2区医学

ACS Infectious Diseases Pub Date : 2026-08-14 Epub Date: 2026-08-01 DOI: 10.1021/acsinfecdis.6c00407

Jingjing Sun, Ying Ni, Mingming Guo, Tao Yu

{"title":"A Multiplex CRISPR-Cas12a-Based Hydrogel Microarray Platform for the Simultaneous Detection of Common Adenovirus Types in Clinical Samples","authors":"Jingjing Sun, Ying Ni, Mingming Guo, Tao Yu","doi":"10.1021/acsinfecdis.6c00407","DOIUrl":"https://doi.org/10.1021/acsinfecdis.6c00407","url":null,"abstract":"Adenovirus infections are a leading cause of respiratoryand gastrointestinaldiseases, representing a significant global health challenge. Rapidand accurate detection of adenovirus types is essential for timelydiagnosis and effective management. Traditional diagnostic methods,such as PCR, are often time-consuming and require complex laboratoryinfrastructure, limiting their application in resource-limited settings.In this study, we present a CRISPR/Cas12a-based assay integrated witha hydrogel microarray for the simultaneous detection of six commonadenovirus types (1, 2, 3, 4, 7, and 14). After amplification of adenoviralDNA using recombinase polymerase amplification (RPA), the amplifiedDNA enters the hydrogel, where it activates the Cas12a-crRNA complextrapped within the gel. This activation leads to the cleavage of anssDNA reporter, generating a fluorescent signal. The use of a hydrogelmicroarray enables efficient and multiplexed detection of adenovirustypes in a single assay. The method demonstrated high sensitivity,with detection limits ranging from 10 to 50 copies/μL acrossthe six adenovirus types. It also showed excellent specificity, withno cross-reactivity observed with other respiratory viruses. Clinicalvalidation with 30 human adenovirus samples revealed 100% specificityand high concordance with qPCR results. This CRISPR/Cas12a-based hydrogelmicroarray platform offers a rapid, cost-effective, and highly specificdiagnostic tool with significant potential for clinical and publichealth applications.","PeriodicalId":17,"journal":{"name":"ACS Infectious Diseases","volume":"12 8","pages":"2815–2824"},"PeriodicalIF":4.5,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148729403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evolutionary Convergence on a Dihydrofolate Reductase Mutation Drives Trimethoprim–Sulfamethoxazole Resistance in Burkholderia thailandensis 泰国伯克霍尔德菌对甲氧苄啶-磺胺甲恶唑耐药的进化趋同研究

IF 4.5 2区医学

ACS Infectious Diseases Pub Date : 2026-08-14 Epub Date: 2026-08-05 DOI: 10.1021/acsinfecdis.5c01132

Sophie Guillier, Christine Lazennec-Schurdevin, Lou Mondange, Véronique Sarilar, Mélissa Marchandeau, Chloé Lemoigne, Ombeline Lamer, Mathilde Lescat, Emmanuelle Schmitt, Yves Mechulam, Julian Garrec, Fabrice Biot

{"title":"Evolutionary Convergence on a Dihydrofolate Reductase Mutation Drives Trimethoprim–Sulfamethoxazole Resistance in Burkholderia thailandensis","authors":"Sophie Guillier, Christine Lazennec-Schurdevin, Lou Mondange, Véronique Sarilar, Mélissa Marchandeau, Chloé Lemoigne, Ombeline Lamer, Mathilde Lescat, Emmanuelle Schmitt, Yves Mechulam, Julian Garrec, Fabrice Biot","doi":"10.1021/acsinfecdis.5c01132","DOIUrl":"https://doi.org/10.1021/acsinfecdis.5c01132","url":null,"abstract":"Trimethoprim–sulfamethoxazole (SXT) remains centralto melioidosiseradication therapy, yet the genetic basis of resistance evolutionin Burkholderia pseudomallei is notfully defined. Using Burkholderia thailandensis as a biosafe surrogate, we subjected populations to stepwise in vitro evolution under increasing SXT concentrations.Whole-genome sequencing revealed rapid population diversificationfollowed by selective sweeps leading to fixation of fitter resistantvariants. Early adaptation involved mutations in regulators of RNDefflux systems and folate-associated genes, consistent with multifactorialresistance. Despite this heterogeneity, all evolutionary trajectoriesconverged on a single nonsynonymous substitution, I99L, in dihydrofolatereductase (DHFR/FolA), which rose to fixation at high SXT concentrations.This substitution mirrors changes reported in SXT-resistant B. pseudomallei isolates from chronic infections.Allelic reconstruction demonstrated that Bt-DHFR(I99L) is sufficientto confer a 4- to 16-fold increase in trimethoprim MIC. Biochemicaland structural analyses showed preserved catalytic activity but reducedtrimethoprim binding, consistent with an allosteric resistance mechanism.Together, these findings establish DHFR as a dominant evolutionarytarget under SXT pressure and support B. thailandensis as a robust model for dissecting resistance evolution in B. pseudomallei.","PeriodicalId":17,"journal":{"name":"ACS Infectious Diseases","volume":"12 8","pages":"2627–2641"},"PeriodicalIF":4.5,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148729394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural and Synthetic AMPs from Latin America across Diversity Engineering and Applications 来自拉丁美洲的天然和合成amp跨越多样性工程和应用

IF 4.5 2区医学

ACS Infectious Diseases Pub Date : 2026-08-14 Epub Date: 2026-07-27 DOI: 10.1021/acsinfecdis.6c00394

José Brango-Vanegas, Elizabete de Souza Cândido, Juliana Carneiro, Nanci Almeida Ribeiro, Octávio Luiz Franco

{"title":"Natural and Synthetic AMPs from Latin America across Diversity Engineering and Applications","authors":"José Brango-Vanegas, Elizabete de Souza Cândido, Juliana Carneiro, Nanci Almeida Ribeiro, Octávio Luiz Franco","doi":"10.1021/acsinfecdis.6c00394","DOIUrl":"https://doi.org/10.1021/acsinfecdis.6c00394","url":null,"abstract":"Latin America’s biodiversity accounts for approximately60% of the world’s total, fueling scientific research intonatural products, a highly relevant area in drug discovery to thisday. This is accompanied by an increasing number of antimicrobialpeptides (AMPs) derived from natural products in the region, whichover the past decade have been redesigned through modifications, enhancements,and refinements of their physicochemical properties and antimicrobialpotency, using approaches that range from rational design and structure–activityrelationship (SAR) studies to artificial intelligence and machinelearning methodologies. AMPs and their derivatives represent a vastchemical space with potential for antibacterial, antifungal, antiviral,and antiparasitic therapies, with emerging applications beyond infectiousdiseases. Over the years, studies have identified these peptides froma wide range of sources, including amphibians, reptiles, invertebrates,and microorganisms from South America, highlighting their diversebiological activities. This raises important questions about whetherLatin America is a fertile source of inspiration for the developmentof AMPs. It also prompts an examination of the region’s historicaland ongoing contributions to the field of natural and synthetic AMPswith anti-infective potential. Additionally, it highlights the needto assess the region’s progress in keeping pace with the recentadvancements in engineering AMPs to combat resistant bacteria. Thismini-review addresses these topics and related issues, exploring LatinAmerica’s discoveries, challenges, and innovations in AMPsand their applications, particularly in anti-infective agents.","PeriodicalId":17,"journal":{"name":"ACS Infectious Diseases","volume":"12 8","pages":"2529–2557"},"PeriodicalIF":4.5,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148729840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting Picornavirus Nonstructural 2C Protein: Structure, Function, and Antiviral Discovery 靶向小核糖核酸病毒非结构2C蛋白：结构、功能和抗病毒发现

IF 4.5 2区医学

ACS Infectious Diseases Pub Date : 2026-08-14 Epub Date: 2026-07-27 DOI: 10.1021/acsinfecdis.6c00387

Kan Li, Guangjin Fan, Wenyi Zhang, Jun Wang

引用次数: 0