Accounts of Chemical Research最新文献

{"title":"New Therapeutic Strategies in the Treatment of Stomal Recurrence After Total Laryngectomy: Role of Immunotherapy.","authors":"Massimo Mesolella, Antonietta Evangelista, Salvatore Allosso, Elide Matano, Giovanni Motta, Gaetano Motta","doi":"10.1177/01455613221121237","DOIUrl":"10.1177/01455613221121237","url":null,"abstract":"<p><p>ObjectiveThe aim of this study was to investigate the incidence of stoma recurrence and the therapeutic strategy outcomes in relation to survival that have been adopted over the past few decades using a monoclonal antibody, specifically nivolumab.MethodsThis study included a total of 487 patients diagnosed with laryngeal carcinoma undergoing either a laryngectomy or salvage surgery after conservative interventions at the ENT Unit of Federico II University in Naples, Italy, between 2011 and 2021. Following a minimum 2.5-year follow-up and a maximum 21-year follow-up, the results revealed that only 38 patients suffered a stomal recurrence.ResultsDespite various adopted treatment strategies, the literature reports lower patient survival rates. Following a total laryngectomy, stomal recurrence represents a therapeutic management challenge due to a poor prognosis for nearly every treated case. According to the literature, in fact, despite a low incidence (ie, 0.8-31.3%), the overall mortality rate increases from 77% to 100% after three years. Nevertheless, introducing immunotherapy into cancer treatment has resulted in an observable revolution in the treatment of different types of cancers over the years.ConclusionIn light of recorded data on survival following the use of the nivolumab, the case presented in this study allows a new perspective of successfully treating recurrences of squamous carcinoma of the head and neck.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"NP432-NP440"},"PeriodicalIF":16.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40375477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A solid mass on the tympanic membrane.","authors":"Ching-Chi Lee, Hsin-Chien Chen","doi":"10.1177/01455613221112344","DOIUrl":"10.1177/01455613221112344","url":null,"abstract":"","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"399-401"},"PeriodicalIF":16.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40719476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mucoepidermoid Carcinoma of the Hard Palate in a Middle-Aged Man.","authors":"Mitchell N Ta, Triet M Do, Amy C Yu, Jagan D Gupta, Neel D Gupta, Enrique Palacios","doi":"10.1177/01455613221121042","DOIUrl":"10.1177/01455613221121042","url":null,"abstract":"","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"NP463-NP464"},"PeriodicalIF":16.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40619052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selective Oxidation of Disparate Functional Groups Mediated by a Common Aspartic Acid-Based Peptide Catalyst Platform.","authors":"Susannah E Huth, Elizabeth A Stone, Scott J Miller","doi":"10.1021/acs.accounts.5c00247","DOIUrl":"10.1021/acs.accounts.5c00247","url":null,"abstract":"<p><p>ConspectusAs drug molecules become increasingly complex, the need to develop new or improved strategies for the efficient and selective synthesis and editing of bioactive compounds grows. Inspired by the high selectivity and fast rates exhibited in many enzymatic reactions to assemble complex natural products, our group and others have developed peptide-based catalysts to mediate synthetically relevant transformations that can be orthogonal, or akin to, native enzymatic reactivity. Peptide catalysts offer several useful features, such as modularity, ease of synthesis, and often enhanced compatibility with synthetic reaction conditions.In one intriguing area, our group has employed the proteinogenic amino acid aspartic acid (Asp) as a catalytic residue embedded within short peptide sequences to selectively introduce a singular oxygen atom into increasingly complex scaffolds, which might constitute a type of single atom editing. Our strategy has involved the development of an aspartic acid/peracid catalytic shuttle, a mechanism that, to our knowledge, has not yet been documented in enzymes.Our foray into Asp-catalyzed oxidation began with the discovery of a peptide sequence to impart enantioselectivity in the epoxidation of minimal olefins. This platform was then extended to include nucleophilic Baeyer-Villiger oxidations and electrophilic <i>N</i>- and <i>S</i>-atom oxidations. Of note, these reactions all use hydrogen peroxide as the stoichiometric oxidant; the appended peptide sequence dictates the selectivity on a per-reaction-type basis. Lead peptides for each transformation were identified using both combinatorial and rational design approaches, and mechanistic studies were used to guide our development along the way or to elucidate modes of action after the fact. In all cases, selectivity was achieved through critical noncovalent interactions between the substrate and peptide catalyst.We have always endeavored to test these catalysts in increasingly complex settings, facing difficult challenges in chemo-, site-, and stereoselectivity in a variety of molecular scaffolds. In a particularly forward-looking example, Asp-peptides were used to perform late-stage molecular editing of geldanamycin, a quintessentially complex and bioactive natural product. Asp-peptides have now also been used to edit the three-dimensional structure of loratadine, the active ingredient in Claritin, to generate helically chiral <i>N</i>-oxide analogues with chemo- and stereoselectivity. In the case of both geldanamycin and loratadine, the oxidized bioactive analogues underwent biological testing, providing insight into the development of future medicinally relevant molecules. Taken together, this Account details the power of Asp-catalysts to address challenges in asymmetric catalysis while also contributing to the need for rapid access to drug analogues.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"2072-2087"},"PeriodicalIF":16.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12226787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144323795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unusual Manifestation of an Extracranial Carotid Artery Aneurysm: Airway Compression.","authors":"Fahri Aydin, Hayri Ogul, Mecit Kantarci","doi":"10.1177/01455613221128122","DOIUrl":"10.1177/01455613221128122","url":null,"abstract":"","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"NP469-NP470"},"PeriodicalIF":16.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33477090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diffuse-type Tenosynovial Giant Cell Tumor Invading the Temporal Bone: Three Cases.","authors":"Qilin Huang, Xia Wu, Qin Xia, Zhen Xie, Hongjun Xiao, Yu Sun, Yulin Jia, Dongxiao Yao, Xuan Guang, Huamao Cheng","doi":"10.1177/01455613221127578","DOIUrl":"10.1177/01455613221127578","url":null,"abstract":"<p><p>Diffuse-type tenosynovial giant cell tumor (D-TSGCT) is a destructive benign tumor-like proliferative disease that occurs in synovial tissue characterized by villous nodular hyperplasia of joints, tendon sheaths, and synovium. D-TSGCT invading the temporal bone originating from the temporomandibular joint (TMJ) is very rare. Here, we report 3 cases of temporal bone D-TSGCT originating from the TMJ. The tumors in the three cases were originating from the TMJ and further invading the middle ear, the carotid foramen or the temporal lobe respectively. The second patient clearly involved the carotid foramen. The third patient clearly affected the temporal lobe. Lesions were completely removed in 3 cases, and all 3 patients were followed up for 30, 20, and 7 months, and none had recurrence. There are very few reports describing such cases. Although this report is not representative of most scenarios, there is still a potential that it provides a relatively reliable surgical idea for similar cases.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"NP450-NP455"},"PeriodicalIF":16.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33477667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Triamcinolone Irrigation in Postoperative Outcomes in Patients Operated for Chronic Rhinosinusitis: A Matched-Pair Randomized Controlled Trial.","authors":"Grace Budhiraja, Navjot Kaur, Harsimrat Singh","doi":"10.1177/01455613221123851","DOIUrl":"10.1177/01455613221123851","url":null,"abstract":"<p><strong>Purpose: </strong>Endoscopic sinus surgery (ESS) is the standard treatment strategy for chronic rhinosinusitis (CRS) resistant to medical treatment, and it is known to have postoperative complications and recurrences, which in turn result in suboptimal outcomes. Several methods are used to prevent postoperative scarring, adhesions, oedema, infection or recurrences in cavities. The role of steroids in improving postoperative outcomes is well established. They can be administered systemically or locally to enhance drug delivery into paranasal sinuses. In this study, we used triamcinolone irrigation immediately following surgery on one side of the nose, in patients with bilateral disease. The objective of this study was to evaluate the effect of intra-operative triamcinolone irrigation on postoperative outcomes, in patients with bilateral pansinusitis.</p><p><strong>Methods: </strong>It was an interventional randomized controlled study, conducted at a tertiary care centre in North India. The analysis of 58 patients with bilateral pansinusitis was done from September 2020 to August 2021. At the conclusion of ESS, each patient was randomized to receive triamcinolone irrigation (4 ml of 40mg/ml solution) once and followed by merocel (polyvinyl acetal) packing on one side, while the contralateral side was packed with merocel soaked with saline. Nasal cavities were evaluated using a Hopkins rod endoscope in the postoperative 1^st, 3^rd, 8^th and 12^th weeks to look for the presence of postoperative crusting, oedema, polypoidal changes, and discharge. Perioperative sinus endoscopic scores (POSE) were used for endoscopic staging.</p><p><strong>Results: </strong>The most commonly affected age group was 31-45 years accounting for 39.7%. Males were affected more (63.7%) than the female population (36.3%). There was a reduction in the average POSE scores at the treatment site at all follow-up stages with a significant reduction in crusting, oedema, and scarring in the treatment site (<i>P</i>-value <0.001).</p><p><strong>Conclusion: </strong>Triamcinolone irrigation effectively improves postoperative outcomes and reduces early postoperative complications in CRS patients.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"411-417"},"PeriodicalIF":16.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33441686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":"58 13","pages":"962–968 XXX-XXX"},"PeriodicalIF":16.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/arv058i013_1953289","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144516737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Amal Tom Sebastian,&nbsp; and ,&nbsp;Charles C. J. Loh*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":"58 13","pages":"962–968 XXX-XXX"},"PeriodicalIF":16.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.accounts.5c00289","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144516733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Soo Bok Kim,&nbsp;Byeong Jun Koo,&nbsp;Sun Bu Lee,&nbsp;Woo Hee Kim and Han Yong Bae*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":"58 13","pages":"962–968 XXX-XXX"},"PeriodicalIF":16.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.accounts.5c00187","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144516736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}