{"title":"Clinical Application of Submental Island Flaps in Repair and Reconstruction of Head and Neck Tumors: Retrospective Review of a Single-Center Experience.","authors":"Pingdong Li, Haiyang Li, Shuo Ding, Jing Zhou, Xiaohong Chen, Jugao Fang, Zhigang Huang","doi":"10.1177/01455613221136671","DOIUrl":"10.1177/01455613221136671","url":null,"abstract":"<p><p>BackgroundBased on our cadaveric study findings and the clinical practice, the improved submental island flaps (SIF) used on a case series to reconstruct postoperative defects were reviewed and analyzed, to summarize the technical operation of flap cutting and propose the anterograde anatomical technique of point-line-plane alignment.MethodsThe cadaveric study was carried out first and a case series of about 23 head and neck tumor cases that underwent one-stage SIF repair were reviewed and followed up. The intraoperative anatomy, the technical essentials for vascular pedicle protection and submandibular lymph nodes treatment, and the rational design of flap incisions were analyzed and described.ResultsMost patients (21/23, 91.3%), comprising 19 males and 4 females with a mean age of 59 years, recovered completely from the application of SIFs in the repair and reconstruction of head and neck tumors; Only 2 patients experienced partial flap necrosis, which resolved following a local dressing change. The predominant donor site complication was transitory paralysis of the mandibular marginal branch of the facial nerve (MMBFN) (3/23, 13.0%), and the donor site was closed in one stage without skin grafting. The hair growth on skin flaps was not an issue for male patients requiring postoperative radiotherapy.ConclusionsSIF is a viable choice for correcting abnormalities of the head and neck tumor with the convenience of flap cutting and the effectiveness of the repair. In addition, it permits simultaneous treatment of the lymph nodes in the region I.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"NP529-NP539"},"PeriodicalIF":16.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40657114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Daniel Häussler, Stefanie Hüttemann, Jörn Brom, Nicole Rotter, Haneen Sadick
{"title":"Long-Term Results of a Multimodal Treatment Regimen in Patients With Auricular Keloids.","authors":"Daniel Häussler, Stefanie Hüttemann, Jörn Brom, Nicole Rotter, Haneen Sadick","doi":"10.1177/01455613221133202","DOIUrl":"10.1177/01455613221133202","url":null,"abstract":"<p><p><b>Objectives:</b> The treatment of auricular keloids is challenging, as they tend to recur; further, the treatment may impact quality of life and implies cosmetic and functional impairment for each patient. There is no standardized therapeutic concept established, and the literature is lacking long-term results of available treatment modalities. <b>Methods:</b> Patients suffering from auricular keloids were included in the study. All patients had undergone surgical resection, intralesional injection of triamcinolone acetonide (TAC), and the application of an individual pressure splint. Quality of life (QoL) was assessed using the keloid intervention benefit inventory 21 (KIBI-21). Further analysis was carried out for patients without (group 1) and with (group 2) recurrence of the keloid. <b>Results:</b> In total, 50 keloids with a mean follow-up period of 59 months (range 6-137 months) could be analyzed. In nine cases (18%), a keloid recurrence was found during the observation period. The assessment of QoL differed significantly between study groups at <i>P</i> = 0.04, as well as for the subcategories General Health (GH) and Physical Health (PH). No differences were found for the categories Social Impact (SI) and Self-Esteem (SE). <b>Conclusions:</b> The multimodal subsequent treatment regimen consisting of surgical resection, intralesional TAC injection, and the application of an individual magnetic pressure splint shows good results concerning long-term recurrence rates. The treatment method shows positive effects on the QoL, especially in the measured categories GH and PH.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"486-492"},"PeriodicalIF":16.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40446319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yue Hu, Namodhi Wijerathne, Md Yeasin Pabel, Dinushika Kotudura Arachchige and Wei David Wei*,
{"title":"Manipulating Plasmon-Generated Hot Carriers for Photocatalysis","authors":"Yue Hu, Namodhi Wijerathne, Md Yeasin Pabel, Dinushika Kotudura Arachchige and Wei David Wei*, ","doi":"10.1021/acs.accounts.5c00313","DOIUrl":"10.1021/acs.accounts.5c00313","url":null,"abstract":"<p >Localized surface plasmon resonance (LSPR), a distinctive optoelectronic property of plasmonic nanocrystals, arises from the collective oscillation of conduction electrons in resonance with incident light. The excitation of LSPR confines incident light near the surface of plasmonic nanocrystals and amplifies the local electric field. Moreover, the frequency of LSPR is highly tunable in the visible and near-IR regions, allowing plasmonic nanocrystals to efficiently absorb and scatter light across the solar spectrum. Such a property makes plasmonic nanocrystals promising candidates for utilizing solar irradiation to drive chemical reactions, a process known as plasmonic photocatalysis. Upon the resonant excitation of LSPR, energetic hot electrons and holes are generated via the nonradiative decay of LSPR in plasmonic nanocrystals. Those hot carriers can be transferred into the molecular orbitals of adsorbed reactants, enabling chemical transformations at the surface of nanocrystals. However, during the charge transport within plasmonic nanocrystals, hot carriers rapidly relax into lower-energy states. As a result, their energy is often dissipated to the lattice as heat, increasing the local temperature rather than directly contributing to chemical reactions─posing a fundamental challenge to achieving efficient solar-to-chemical energy conversion using plasmonic nanocrystals.</p><p >To address this challenge, our group has developed multiple strategies to control the lifetime, energy level, and spatial distribution of plasmon-generated hot carriers to enhance the photocatalytic activity of Au nanocrystals. To extend the lifetime of hot carriers to match the slow kinetics of chemical reactions, Au nanocrystals were attached to an n-type semiconductor to form a heterojunction. This structure was found to prolong the lifetime of hot electrons through efficient spatial separation of hot electrons and holes, facilitated by the Schottky barrier at the metal/semiconductor interface. In parallel, decorating Au nanocrystals with redox-active molecules was shown to extend the lifetime of hot holes. Those hot holes were chemically stabilized and trapped within the bonds of the redox-active species, allowing them to participate in subsequent chemical reactions. Furthermore, a direct correlation between the activity of hot-electron-driven reduction reactions and the size of plasmonic nanocrystals, as well as between hot-hole-driven oxidation reactions and the wavelength of incident light, was established. Those observations demonstrated that energy levels of hot carriers involved in chemical reactions can be manipulated by tuning the size of nanocrystals and the wavelength of light. Moreover, positively charged molecules with facet-selective adsorption on Au nanocrystals were found to stabilize the plasmon-generated hot electrons, enabling control over the spatial distribution of hot carriers. Manipulating plasmon-generated hot carriers not only enhances the","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":"58 16","pages":"2562–2572"},"PeriodicalIF":17.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparison of cartilage and temporalis fascia grafts in type 1 tympanoplasty: A meta-analysis.","authors":"Kai Chen, Rui Zhao","doi":"10.1177/01455613221137122","DOIUrl":"10.1177/01455613221137122","url":null,"abstract":"<p><p>ObjectiveTo systematically review the results of type 1 tympanoplasties with temporalis fascia (TF) vs cartilage grafts in patients with chronic otitis media.MethodsEligible studies were identified from PubMed, Ovid, and EMBASE databases prior to November 2021. We analyzed the pure tone audiometry (PTA) and air-bone gap (ABG) data as continuous variables, and the success rate was analyzed as a dichotomous variable.ResultsForty-four studies, including 4582 patients, were eligible. The cartilage graft overall morphologic success rate was higher than that of the TF grafts (<i>P</i> < .001). In the palisade (<i>P</i> < .004) and island grafts (<i>P</i> < .001) subgroups, the analysis was significantly different. However, there was no significant difference in the inlay butterfly grafts subgroup. For hearing outcomes, the analysis revealed that TF grafts had a smaller mean post-operative ABG (<i>P</i> = .009). However, the subgroup analysis showed no significant difference in the mean post-operative ABG. For PTA, there was no significant difference in hearing improvement. However, the palisade cartilage graft subgroup resulted in a better hearing outcome than the TF graft subgroup in terms of the mean post-operative PTA (<i>P</i> = .007). There was no significant difference in the functional success rate or mean ABG gain.ConclusionCartilage grafts have a better success rate than TF grafts in tympanoplasty. Both cartilage and TF tympanoplasty provided similar improvements in hearing outcome, while TF grafts generated a better outcome in post-operative ABG and palisade cartilage grafts in post-operative PTA. This may be related to the biological characteristics of the grafts. Further thorough studies need to be conducted.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"NP476-NP489"},"PeriodicalIF":16.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40428086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nancy L Trang, Gillian Robinson-Warner, Spiridon G Karavatas, Brian Laurence, Sefa Laurence, Albert Cheek, Candace Mitchell
{"title":"Fear of COVID-19 among dental students at a Historically Black College and University (HBCU).","authors":"Nancy L Trang, Gillian Robinson-Warner, Spiridon G Karavatas, Brian Laurence, Sefa Laurence, Albert Cheek, Candace Mitchell","doi":"10.1080/07448481.2022.2100997","DOIUrl":"10.1080/07448481.2022.2100997","url":null,"abstract":"<p><strong>Objective: </strong>To examine fear levels of COVID-19 among dental students at a Historically Black College and University (HBCU). Participants-162 first through fourth year dental students who were enrolled at the HBCU dental school between January 27, 2021 and May 3, 2021.</p><p><strong>Methods: </strong>Students completed an online survey that included the Fear of COVID-19 Scale (FCV-19S) and information on demographic variables.</p><p><strong>Results: </strong>Associations were observed between the fear of COVID-19 and the dental student's gender, ethnicity, marital status and self-rated health. Those in the highest quartile for the fear scale were less likely to be African American and more likely to be Asian or Pacific Islander, Hispanic or of Middle Eastern descent as compared to those in the lowest quartile.</p><p><strong>Conclusion: </strong>Dental students at an HBCU are a population particularly vulnerable to fear of COVID-19 possibly due to the high demands and mental stress of dental school.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"2777-2780"},"PeriodicalIF":17.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40505075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ayşegül Erdoğan, Deniz Tuncel, Sedat Işikay, Ramazan A Okyay
{"title":"Restless legs syndrome and headache cause sleepiness and consequent poor school performance: a community-based study from Turkey.","authors":"Ayşegül Erdoğan, Deniz Tuncel, Sedat Işikay, Ramazan A Okyay","doi":"10.23736/S2724-5276.21.06303-5","DOIUrl":"10.23736/S2724-5276.21.06303-5","url":null,"abstract":"<p><strong>Background: </strong>Disturbance of sleep habits leads to excessive daytime sleepiness (EDS), which may affect learning abilities and consequently academic performance. Therefore, the main aim of current paper was to determine the prevalence of headache and Restless legs syndrome (RLS) in school-aged adolescents and to evaluate the type of headache in adolescents, with a secondary aim to determine the effect of daytime sleepiness on academic success.</p><p><strong>Methods: </strong>This cross-sectional study was conducted on adolescents aged between 15 and 19 years of age, who were in high school education in the 2016-2017 academic years in Kahramanmaraş province. A comprehensive interview form including questions on demographic data, RLS diagnostic criteria, headache, and Epworth Sleepiness Scale (ESS) was applied to a total of 4151 students.</p><p><strong>Results: </strong>RLS was found in 3.2% of the participants in all age groups. The mean ESS scores in adolescents with RLS were significantly higher than in those without RLS. Headache was reported by 46.9% of the adolescents in the study, with a frequency of TTH type headache of 17.7% and migraine frequency of 5.2%. RLS frequency was determined to be significantly higher in adolescents with headache and migraine. The academic success rate was significantly lower in those with higher ESS scores.</p><p><strong>Conclusions: </strong>Migraine and RLS often coexist as comorbid conditions. EDS is an important factor affecting academic success in children. Headache and RLS should not be forgotten, among other reasons for increased daytime sleepiness and its etiology.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"314-319"},"PeriodicalIF":16.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39252949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sarah E Toth, M Christine Highfill, Isia K Jenkins, Rakiya D Battle
{"title":"Exercise stages of change and barriers among undergraduates at a historically black university.","authors":"Sarah E Toth, M Christine Highfill, Isia K Jenkins, Rakiya D Battle","doi":"10.1080/07448481.2022.2115843","DOIUrl":"10.1080/07448481.2022.2115843","url":null,"abstract":"<p><p><b>Objective:</b> To investigate exercise stages of change (SOC) and physical barriers among undergraduates at an Historically Black University (HBCU) and quantify their relationship. <b>Participants:</b> A total of 326 undergraduate HBCU students; 198 were females (body mass index (BMI) range 16.5-87.9; <i>M</i> = 26.5 ± 6.8) and 127 were males (BMI range 18.0-49.3; <i>M</i> = 26.4 ± 5.7). <b>Methods:</b> Students voluntarily completed a three-section survey: demographic questions, Exercise SOC, and Barriers to Being Active Quiz (BBAQ). <b>Results:</b> An ANOVA determined significant differences (<i>p</i> < . 001) between the means for each SOC for lack of time, social influence, lack of energy, lack of willpower, and lack of skill. Significant differences (<i>p</i> < . 001) existed between SOC and BBAQ score, as well as number of important barriers. <b>Conclusions:</b> HBCU interventions should address time management, energy, motivation, social support, and skill development to promote exercise and reduce barriers, especially among Black women.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"2781-2788"},"PeriodicalIF":17.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40380471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Expression of concern.","authors":"","doi":"10.1080/17549507.2022.2121886","DOIUrl":"10.1080/17549507.2022.2121886","url":null,"abstract":"","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"619"},"PeriodicalIF":17.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33462411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Geethanjeli N Mahendran, Ching Siong Tey, Mary Frances Musso, Grace Shebha Anand, Jeffrey Larson, Mitesh Mehta, Lara Reichert, Kara Prickett, Nikhila Pinnapureddy Raol
{"title":"Measuring the Impact of a Delay in Care on Pediatric Otolaryngologic Surgery Completion.","authors":"Geethanjeli N Mahendran, Ching Siong Tey, Mary Frances Musso, Grace Shebha Anand, Jeffrey Larson, Mitesh Mehta, Lara Reichert, Kara Prickett, Nikhila Pinnapureddy Raol","doi":"10.1177/01455613221134428","DOIUrl":"10.1177/01455613221134428","url":null,"abstract":"<p><p><b>Objective:</b> To determine if postponement of elective pediatric otorhinolaryngology surgeries results in a change in overall healthcare utilization and if there is any commensurate impact on disease progression. <b>Methods:</b> We identified patients ≤18 years of age whose surgeries were postponed at the onset of the COVID-19 pandemic-related shutdown. We then tracked patients' rate of and patterns of rescheduling surgery. Surveys were also sent to caregivers to better characterize his/her decision regarding moving forward with his/her child's surgery during COVID-19. <b>Results:</b> A total of 1915 pediatric patients had elective surgeries canceled, of which 992 (51.8%) were rescheduled within 4 months. No difference in rates of rescheduling was identified based on race or ethnicity. Patients who were scheduled for tonsillectomies and/or adenoidectomies were 1.22 times more likely to reschedule compared to those patients with other planned procedures (CI: 1.02-1.46). A total of 95 caregivers at two hospitals completed surveys: 44 (47.4%) rescheduled their child's surgery. Most caregivers who rescheduled were concerned their child's disease could impact their future (n = 14, 32%). <b>Conclusions:</b> Just over half of patients who had pediatric otolaryngologic surgery canceled during a period of social distancing went on to have surgery within a 4-month timeframe. This reflects the dependence of pediatric otolaryngologic surgery on environmental exposures and may represent a potential target for prevention and management of some pediatric otolaryngology diseases.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"NP558-NP564"},"PeriodicalIF":16.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33512690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Survival comparison of different histological subtypes of oropharyngeal squamous cell carcinoma: A propensity-matched score analysis based on SEER database.","authors":"Tao Li, Yi Wang, Xianwang Xiang, Chuanjun Chen","doi":"10.1177/01455613221136360","DOIUrl":"10.1177/01455613221136360","url":null,"abstract":"<p><p>ObjectiveThe purpose of this study was to analyze the difference of survival rates in paitents with oropharyngeal keratinizing squamous cell carcinoma (KSCC), nonkeratinizing squamous cell carcinoma (NKSCC), basaloid squamous cell carcinoma (BSCC), and papillary squamous cell carcinoma (PSCC).Materials and methodsPatients diagnosed with oropharyngeal squamous cell carcinoma between 2004 and 2015 were collected from the SEER database. Cox proportional hazards models and Kaplan-Meier curves were used for survival analysis. Propensity score matching (PSM) was performed to adjust for the effect of confounding variables. Due to the small sample size of PSCC, this study did not perform PSM between it and other subtypes.ResultsThe 5-year cancer-specific survival (CSS) rate of PSCC was higher than that of KSCC, NKSCC, and BSCC (0.627 vs. 0.812 vs. 0.789 vs. 0.875, <i>P</i> < 0.05); And the CSS rate of KSCC was lower than that of other subtypes both before and after PSM. In addition, the 5-year and 10-year CSS rates of BSCC were not different from NKSCC (<i>P</i> > 0.05), but not as good as NKSCC in the long term (<i>P</i> = 0.028). After PSM, the 5-year, 10-year, and long-term prognosis of BSCC were significantly worse than those of NKSCC (<i>P</i> < 0.001).ConclusionThe 5-year CSS of PSCC was better than the other three subtypes. The short-term prognosis of BSCC was not significantly different from NKSCC, but the long-term survival was lower than that of NKSCC, and the difference was more obvious after PSM. Meanwhile, the prognosis of KSCC was worst.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"NP518-NP528"},"PeriodicalIF":16.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40447310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}