Accounts of Chemical Research最新文献_第9页

IF 17.7 1区化学

Accounts of Chemical Research Pub Date : 2025-08-05

Ryan J. Malone, and , Wesley A. Chalifoux*,

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IF 17.7 1区化学

Accounts of Chemical Research Pub Date : 2025-08-05

Min-Sung Ko, and , Dong-Gyu Cho*,

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IF 17.7 1区化学

Accounts of Chemical Research Pub Date : 2025-08-05

引用次数: 0

IF 17.7 1区化学

Accounts of Chemical Research Pub Date : 2025-08-05

Stephen M. Hinshaw*, Steven M. Banik and Nathanael S. Gray,

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IF 17.7 1区化学

Accounts of Chemical Research Pub Date : 2025-08-05

Yuxin Fang, and , Peng Zou*,

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IF 17.7 1区化学

Accounts of Chemical Research Pub Date : 2025-08-05

Michael Dürr*, Ulrich Höfer, Ulrich Koert* and Ralf Tonner-Zech,

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IF 17.7 1区化学

Accounts of Chemical Research Pub Date : 2025-08-05

Yuanyuan Ping, Sheng Xu and Wangqing Kong,

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Chromium-Catalyzed Radical-Involved Asymmetric Carbonyl Additions 铬催化自由基参与的不对称羰基加成。

IF 17.7 1区化学

Accounts of Chemical Research Pub Date : 2025-08-04 DOI: 10.1021/acs.accounts.5c00489

Haigen Shen, Xiaowen Xia, Zhaoxin Shi and Zhaobin Wang*,

{"title":"Chromium-Catalyzed Radical-Involved Asymmetric Carbonyl Additions","authors":"Haigen Shen, Xiaowen Xia, Zhaoxin Shi and Zhaobin Wang*, ","doi":"10.1021/acs.accounts.5c00489","DOIUrl":"10.1021/acs.accounts.5c00489","url":null,"abstract":"Asymmetric carbonyl addition reactions have long been recognized as a powerful platform for synthesizing chiral alcohols, garnering significant attention in synthetic chemistry. Over the past few decades, notable progress has been made in this field through the use of organometallic reagents and two-electron polar addition processes. However, these approaches often face challenges related to functional group compatibility, particularly when employing strongly basic alkyl nucleophiles, and the construction of vicinal stereocenters remains difficult due to the limited availability of chiral alkylmetal nucleophiles, whether presynthesized or formed in situ. As a result, there is a continued demand for the development of alternative strategies for asymmetric carbonyl additions.Radical reactions, known for their high functional group tolerance, mild reaction conditions, and distinct reactivity, offer a promising alternative to traditional polar processes. Specifically, radical-based asymmetric carbonyl additions present a compelling solution to the aforementioned challenges. Despite their potential, several hurdles remain, including (1) challenging reactivity control due to the thermodynamically unfavorable direct radical carbonyl addition, (2) undesired background reactions and difficulties in controlling stereoselectivity due to the transient nature of radical intermediates, and (3) the complexities in elucidating the mechanisms involving radical species. Drawing inspiration from the Nozaki–Hiyama–Kishi reactions, our group has focused on establishing a robust platform for radical-based asymmetric carbonyl additions using chromium catalysis. This approach has enabled previously challenging asymmetric transformations and provided new insights into the underlying mechanisms.In this Account, we summarize our key achievements in the field, categorized by various radical generation strategies, and highlight the significant potential of chromium-catalyzed asymmetric carbonyl additions for synthesizing useful chiral molecules with vicinal stereocenters and their synthetic applications. We first established Cr-catalyzed asymmetric additions to aldehydes and ketones using racemic alkyl halides as radical precursors. Additionally, we explored the use of protected imines, activated alkenes, conjugate dienes, 1,3-enynes, and racemic allenes as effective radical precursors in asymmetric additions to aldehydes, enabled by Cr catalysis or metallaphotoredox catalysis. Furthermore, we developed a triple-catalysis system to achieve the asymmetric α-C–H addition of N-sulfonyl benzylamines to aldehydes, producing β-amino alcohols with vicinal stereocenters.Extensive studies, including radical trapping, UV–vis spectroscopy, kinetic isotope effects, and DFT calculations, have revealed two principal transition state (TS) models. For alkyl radicals bearing α π functionalities (e.g., double/triple bonds, carbonyl groups), the reacti","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":"58 16","pages":"2652–2670"},"PeriodicalIF":17.7,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144782978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Chiral Inorganic Nanomaterials for Biological Features 生物特征手性无机纳米材料。

IF 17.7 1区化学

Accounts of Chemical Research Pub Date : 2025-08-04 DOI: 10.1021/acs.accounts.5c00364

Meiru Lu, Aihua Qu, Xue Huang, Tongguo Shi, Weichang Chen*, Chuanlai Xu*, Hua Kuang* and Guangbo Zhang*,

{"title":"Chiral Inorganic Nanomaterials for Biological Features","authors":"Meiru Lu, Aihua Qu, Xue Huang, Tongguo Shi, Weichang Chen*, Chuanlai Xu*, Hua Kuang* and Guangbo Zhang*, ","doi":"10.1021/acs.accounts.5c00364","DOIUrl":"10.1021/acs.accounts.5c00364","url":null,"abstract":"Inorganic nanomaterials typically exhibit a wide variety of structures with flexibility and versatile functional properties. The introduction of chirality can influence the physicochemical properties of materials, such as their size, shape, crystal structure, surface charge and optical activity. These properties can directly affect the in vivo fate of chiral inorganic nanomaterials. Given the inherent chirality and enantiomer selectivity of biological systems, there has been increasing interest in manipulating the chirality of nanomaterials to enhance biomolecular interactions and improve stability and target selectivity. This has led to remarkable advancements, establishing nanomaterial chirality as a highly innovative research domain. Based on controlling the synthesis of chiral nanomaterials, various design models can be developed for the regulation of diverse biological processes, thereby continuously contributing to the development of the next-generation chirality-based platforms toward nanobiomedicine.In this Account, we introduce recent advances and representative works on chiral inorganic nanomaterials, and summarize our efforts in this area. Initially, we highlight the design principles and fabrication strategies of chiral noble metals, chiral metal oxides, chiral inorganic semiconductors, and chiral metal hybrid nanomaterials, while analyzing the underlying origins of chirality in detail. We investigate the effects of various chiral molecules, circularly polarized light (CPL), and magnetic fields on chiral structures and chiral preferences. Furthermore, we outline emerging applications of such functional chiral inorganic nanomaterials in biomedical fields, including biosensing, biocatalysis, immune modulation, cellular behavior regulation, antibacterial effects, and disease theranostics. Chiral inorganic nanomaterials demonstrate enantioselective interactions with biological molecules (e.g., amino acids, peptides, DNA sequences, and proteins), and possess various responsive properties (e.g., redox, enzyme, light, and magnetic effects), playing crucial roles in the regulation of biological processes. Finally, we share our perspectives on the enduring challenges and future opportunities of this important and rapidly advancing field. It is envisioned that the precise design and controlled synthesis of chiral inorganic nanomaterials will facilitate the development of materials with advanced functional properties to meet the requirements of diverse emerging technologies.","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":"58 16","pages":"2613–2626"},"PeriodicalIF":17.7,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144769864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Cochlear Implantation: The Variation in Cochlear Height. 人工耳蜗植入：人工耳蜗高度的变化。

IF 16.4 1区化学

Accounts of Chemical Research Pub Date : 2025-08-01 Epub Date: 2022-10-17 DOI: 10.1177/01455613221134860

Afrah Alshalan, Yassin Abdelsamad, Majed Assiri, Abdulrahman Alsanosi

{"title":"Cochlear Implantation: The Variation in Cochlear Height.","authors":"Afrah Alshalan, Yassin Abdelsamad, Majed Assiri, Abdulrahman Alsanosi","doi":"10.1177/01455613221134860","DOIUrl":"10.1177/01455613221134860","url":null,"abstract":"This study aimed to identify the association between different cochlear metrics, including the basal turn diameter (A-value), the basal turn width (B-value), and the height of the cochlea (H-value). We also reported an association between H-value and hearing outcomes with cochlear implants (CI). This is a retrospective study that included all patients who underwent CI procedures between 2012 and 2018 at a tertiary center and have; preoperative high-resolution computed tomography (CT), normal cochlea, postoperative follow-up duration of at least 2 years, scores of the category auditory performance II (CAP-II), and speech intelligibility rating (SIR) scales. A total of 65 ears implanted with CI in 46 patients (24 boys and 20 girls; mean age of 7 (±10) years) fulfilled the inclusion criteria. We found significant positive correlations between A vs B, A vs H, and B vs H (P-value = 0.008, 0.018, and 0.0039, respectively). We also found a significant positive relationship between A, B, and H values and cochlear duct length (CDL) (P-value < 0.0001, 0.008, and 0.018, respectively). Finally, the H-value was significantly correlated with the SIR (P-value = 0.027). However, its correlation with the CAP score was not statistically significant (P-value = 0.62). Cochlear height significantly correlated with CDL and the other cochlear parameters. The variation in cochlear height can also affect speech outcomes in patients undergoing CI. Therefore, the H-value together with the other cochlear metrics should be adequately assessed preoperatively in CI patients.","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"501-507"},"PeriodicalIF":16.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33517637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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