Food & Function最新文献

{"title":"High-fat diet supplemented with soybean diacylglycerol oil protects liver homeostasis <i>via</i> maintaining endoplasmic reticulum function in C57BL/6J mice.","authors":"Jia Guo, Fangyingnan Zhang, Yunjiao Zhang, Yonghua Wang","doi":"10.1039/d3fo04374f","DOIUrl":"https://doi.org/10.1039/d3fo04374f","url":null,"abstract":"<p><p>Diacylglycerol-rich edible oil can prevent obesity-induced hyperlipidaemia in both animals and humans, while the effect of diacylglycerol-rich oil diets on liver function remains poorly understood. Therefore, male C57BL/6J mice were separately fed with different meals, including 7% (w/w) soybean triacylglycerol oil, 25% (w/w) soybean triacylglycerol oil or 25% (w/w) soybean diacylglycerol oil for 12 weeks. A soybean diacylglycerol oil-based high-fat diet preserved plasma lipid levels and liver function, whereas a soybean triacylglycerol oil-based high-fat diet caused elevated levels of plasma lipids and excess hepatic fat deposition. Endoplasmic reticulum dysfunction is a marker reflecting aggravated hepatic disorders and hyperlipidaemia. Transcriptome sequencing revealed that the soybean diacylglycerol oil-based high-fat diet maintained the expression of several key genes in endoplasmic reticulum function. The results of serum lipidomic profiles showed that the soybean diacylglycerol oil-based high-fat diet caused less hepatoxic lipid metabolites such as lysophosphatidylcholine that drives liver damage <i>via</i> triggering endoplasmic reticulum stress. Our findings imply that replacing triacylglycerol with diacylglycerol in a high-fat diet can protect liver homeostasis by maintaining endoplasmic reticulum function caused by inhibiting an increase in lysophosphatidylcholine.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Krill oil alleviates type 2 diabetes mellitus-induced sarcopenia in mice <i>via</i> attenuating insulin resistance, intestinal barrier dysfunction, and skeletal muscle protein turnover impairment.","authors":"Shi-Xiang Wu, Xin-Yue Zhao, Yu-Hong Yang, Meng-Qing Zhou, Yan Zheng, Zi-Jian Wu, Qing-Yan Zou, Tian-Tian Zhang, Lei Du","doi":"10.1039/d5fo02415c","DOIUrl":"https://doi.org/10.1039/d5fo02415c","url":null,"abstract":"<p><p>Krill oil (KO), a source of EPA, DHA, phospholipids, and astaxanthin, has emerged as a promising functional ingredient to maintain skeletal muscle health. However, its protective role against type 2 diabetes mellitus (T2DM)-induced sarcopenia has remained poorly characterized. Hence, the present study aimed to investigate the protective effects and underlying mechanisms of KO against sarcopenia in both a T2DM mouse model induced by the combination of streptozotocin and high-fat, high-sucrose diet, and a C2C12 myotube atrophy model induced by high glucose (HG), advanced glycation end products (AGEs), and lipopolysaccharide (LPS). Incorporation of 1.5% KO (w/w) in the diet of mice with T2DM for 24 weeks significantly enhanced insulin sensitivity, lowered blood glucose levels, and decreased serum and muscle AGEs levels. Additionally, dietary KO markedly ameliorated intestinal barrier dysfunction in mice with T2DM, as evidenced by the improvement of intestinal pathological injuries, the decrease of serum and muscle LPS levels, and the restoration of the expression of tight junction proteins. Dietary KO also significantly mitigated skeletal muscle mass and strength loss in mice with T2DM, and alleviated HG/AGEs/LPS-induced C2C12 myotube atrophy. Moreover, dietary KO effectively reduced the overproduction of pro-inflammatory cytokines and ROS accumulation in the skeletal muscle of mice with T2DM and in HG/AGEs/LPS-stimulated C2C12 myotubes. Furthermore, dietary KO alleviated T2DM-induced skeletal muscle protein turnover impairment both <i>in vivo</i> and <i>in vitro</i>, as demonstrated by increased <i>de novo</i> protein synthesis <i>via</i> activating the PI3K/Akt/mTOR signaling pathway, and inhibited excessive protein degradation through inactivating the FoxO3a- and NF-κB-mediated up-regulation of MAFbx and MuRF1. Overall, our findings suggested that KO might have therapeutic potential against T2DM-induced sarcopenia.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deformation, mechanical breakdown, and flow of soft solid foods in the stomach.","authors":"Shouryadipta Ghosh, Simon M Harrison, Paul W Cleary","doi":"10.1039/d4fo04217d","DOIUrl":"https://doi.org/10.1039/d4fo04217d","url":null,"abstract":"<p><p>Mechanical changes to solid foods in the stomach are crucial aspects of processes for regulating nutrient bioavailability, satiety, and glycaemic response after a meal. However, the underlying mechanisms are poorly understood. This study uses a Smoothed Particle Hydrodynamics (SPH) model to study the deformation and mechanical breakdown of solid beads in a liquid medium within a realistic three-dimensional representation of the stomach geometry. The model incorporates peristaltic contraction waves, including Terminal Antral Contractions (TACs), which are high-amplitude and high-speed travelling occlusions observed in the distal region of the stomach. The solid beads are modelled using elastic-plastic (EP) and elastic-brittle (EB) constitutive laws. Results show that the stomach wall can induce significant compression and fragmentation in the solid beads through direct contact, and the accompanying fluid flow contributes towards further mechanical change. An originally spherical EP bead closest to the pylorus is extruded into a thin cylindrical shape, generating 15 fragments with a 5% higher surface area, before being propelled away from the TAC region. A model-parameter sensitivity analysis shows that an increase in yield stress substantially reduces the fragmentation but not the elongation. An EB bead near the pylorus deforms less but fractures into 235 small fragments and a large chunk, leading to an overall 12% higher surface area. The EB bead remains near the pylorus, fracturing further over multiple peristaltic cycles. Increased fracture strength, represented by a higher threshold strain, significantly reduces the surface area change and the number of fragments generated by the wall contractions. These results show how a coupled biomechanics-fluid-elastic-plastic-fracture model can be used to investigate the mechanical breakdown of solid foods in the stomach.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Galician phenolic-rich olive oil as a glycemic control strategy: the OILDIABET randomized trial.","authors":"María Figueiredo-González, Inés Seoane-Cruz, Patricia Reboredo-Rodríguez, Eva Fernández-Rodríguez, Manuel Marcos-García, María José Menor-Rodríguez, Beatriz Calderón-Cruz, Carmen González-Barreiro, José Antonio Mato-Mato, Beatriz Cancho-Grande","doi":"10.1039/d5fo00873e","DOIUrl":"https://doi.org/10.1039/d5fo00873e","url":null,"abstract":"<p><p>The rising prevalence of type 2 diabetes (T2D) demands effective dietary strategies. High-phenolic extra virgin olive oil (EVOO) has been proposed as a functional food with antidiabetic properties. This study evaluates the effects of a high-phenolic EVOO from native Galician olives on glycemic control (primary outcome), lipid profile, anthropometric and blood pressure parameters (secondary outcomes) in adults with T2D. A 24-week experimental, prospective, randomized, parallel, long-term controlled trial was conducted with 116 T2D subjects. Participants were randomly allocated either to a Control group advised to minimize consumption of EVOO (preferring refined olive oil blends) or an Interventional group receiving 30 mL day^-1 of Galician phenolic-rich EVOO. Glycemic biomarkers, lipid profile, anthropometric indices, and blood pressure were assessed at baseline, 12 and 24 weeks. After 24 weeks, the Interventional group demonstrated significant reductions in insulin resistance (HOMA IR). No significant changes were observed in lipid profile or blood pressure in either group, while both groups exhibited modest reductions in body weight and body mass index (BMI). Although beneficial effects were particularly pronounced among individuals with obesity (reductions in fasting glucose, estimated average glucose and glycosylated hemoglobin (HbA1c)) and insulin-resistant participants (reductions in fasting insulin and HOMA IR), these subgroup analyses lacked sufficient statistical power and must be interpreted cautiously. These findings highlight the therapeutic potential of phenolic-rich EVOOs as a complementary dietary strategy for managing T2D.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144657859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attenuation of colitis-related metabolic dysregulation <i>via</i> consumption of wholemeal sourdough bread but not wholemeal bread: a molecular discovery.","authors":"Cheng Chen, Gaoheng Li, Anqi Wang, Jacob Ojobi Omedi, Chengye Huang, Angelo Uriho, Li Liang, Zhongkai Zhou, Weining Huang, Ning Li","doi":"10.1039/d5fo02108a","DOIUrl":"https://doi.org/10.1039/d5fo02108a","url":null,"abstract":"<p><p>Epidemiological studies reveal that the majority of adult patients with inflammatory bowel disease (IBD) are obese and/or overweight. Whole wheat sourdough produced by lactic acid bacterial (LAB) fermentation can provide numerous benefits. In this study, the potential therapeutic effects of consuming whole wheat sourdough bread (singly fermented by two high-metabolite-producing LAB strains, <i>Lactobacillus crustorum</i> (LC) or <i>Lactobacillus fermentum</i> (LF)) on colon and liver metabolic function in an obese (high-fat diet) and ulcerative colitis (5% dextran sulfate sodium, DSS) induced male rat model were investigated, and the underlying mechanisms were investigated <i>via</i> multi-omics approaches. The results showed that compared to the obesity-colitis model (OC), intake of whole wheat sourdough bread diets rather than wheat bread (WB) or whole wheat bread (WW) effectively restored liver morphology, normalized colon length, and lowered colonic oxidative stress by reducing the levels of malondialdehyde (MDA) and diamine oxidase (DAO), reduced the pro-inflammatory cytokines (IL-1β, IL-6, IL-22) levels, while increasing the anti-inflammatory cytokine (IL-10) levels in serum of the colitis-obesity induced rat model. Moreover, the abundance of butyrate-producing bacteria, such as <i>Oscillospiraceae</i> and <i>Butyricoccaceae</i>, and <i>Akkermansia</i>, was enhanced after consuming whole wheat sourdough bread, in a strain-dependent manner. Importantly, a significantly higher content of short-chain fatty acids (SCFAs) was found in the feces for the two LAB-fermented sourdough groups, which counteracted the antinutritional factors in whole wheat. Furthermore, the transcriptomic and metabolomic analysis suggested that the underlying mechanism in the LF group was linked to the suppressed MAPK signaling pathway and activated T cell-mediated immune regulation, whereas in the LC group the mechanism involved enhanced DNA repair, activation of T/B-cell responses, and modulation of the vascular microenvironment through antioxidant pattern (ascorbic acid). Meanwhile, enhanced energy metabolism (α-ketoglutaric acid, carnitine) and anti-apoptotic effects (ceramide) were also achieved following this intervention. In conclusion, although LAB strain dependence was observed, the current findings revealed that intake of whole wheat sourdough bread ameliorated the symptoms of colitis in the colitis-obesity rat model <i>via</i> the regulation pattern of the \"LAB fermentation → butyrate-producing bacteria\" metabolic axis.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144657857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive release and modulation of urolithin metabotype A phenotype gut microbiota during <i>in vitro</i> digestion and fermentation of ellagic acid-rich fruit polyphenols.","authors":"Zhike Xie, Feng Chen, Yawen Xiao, Jiaxin You, Xiaojun Zhou, Pei Li, Quancheng Zhou, Zheng Ruan","doi":"10.1039/d4fo06221c","DOIUrl":"https://doi.org/10.1039/d4fo06221c","url":null,"abstract":"<p><p>Ellagic acid-rich fruits (EARFs) are valued for their bioactive compounds, yet their gastrointestinal biotransformation remains insufficiently understood. This study investigated the functional transformation of phytochemicals, antioxidant effects, and microbial shifts related to the urolithin metabotype-A phenotype during the simulated gastrointestinal digestion and colonic fermentation of four freeze-dried EARF powders: raspberry (RA), strawberry (ST), Chinese chestnut (CC), and pomegranate (PO). Simulated digestion markedly decreased the phenolic content in all groups, which was strongly associated with reduced antioxidant capacity. Across all groups, 24 phenolics were found, and the levels of most compounds dropped notably after digestion. Fecal microbiota from urolithin-A producers fermented the digested powders, resulting in increases in beneficial bacteria like <i>Bifidobacterium</i> and elevated short-chain fatty acid (SCFA) production. <i>Lactobacillus</i> was identified as a key contributor to EA metabolism and Uros production. Functional prediction analysis revealed distinct functional enrichments among EARF powders, corresponding to their compositional differences. Among the groups, ST and RA retained higher phenolic levels, which contributed to their stronger antioxidant capacity, while PO more effectively promoted SCFA production. All groups showed distinct modulation of the gut microbiota composition. The results underscore the value of EARF powders as functional foods capable of improving gut health by modulating the microbiota and promoting the generation of beneficial metabolites.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144657858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a bio-functional fermented soy beverage supplemented with microbial exopolysaccharides and its effect on the human gut microbiome <i>in vitro</i>.","authors":"Giulia Bisson, Clara Comuzzi, Jamie A FitzGerald, Arghya Mukherjee, Niccolò Renoldi, Nadia Innocente, Tom Beresford, Harsh Mathur, Paul D Cotter, Marilena Marino","doi":"10.1039/d5fo01288k","DOIUrl":"https://doi.org/10.1039/d5fo01288k","url":null,"abstract":"<p><p>The gut microbiome plays a key role in modulating human health and well-being. Exopolysaccharides (EPS) produced by lactic acid bacteria (LAB) are emerging as novel polymers that could exert a prebiotic effect <i>via</i> modification of this microbiome. Thus, incorporation of EPS to enhance food functionality is of interest. This study investigates the impact of a fermented soy beverage, supplemented with EPS produced by <i>Leuconostoc mesenteroides</i> DSA_O or DSA_F, on the faecal microbiota as assessed using an <i>ex vivo</i> model of the human distal colon. The soy beverage (SM) was prepared by fermentation with <i>Lactiplantibacillus paraplantarum</i> GB3 followed by supplementation with EPS_O (SMO) or EPS_F (SMF). Faecal samples from healthy donors were inoculated into a faecal fermentation medium with SM, SMO and SMF and incubated anaerobically at 37 °C for 24 h. After incubation, samples were subjected to shotgun metagenomic and short-chain fatty acid (SCFA) analysis. SMO and SMF were more effective than SM at enhancing the alpha diversity of the faecal microbiota after 24 h incubation. In addition, SMO promoted the growth of the health-associated species <i>Bifidobacterium longum</i> and <i>Faecalibacterium prausnitzii</i>, the latter of which is considered a next-generation probiotic. Butyrate and propionate levels were higher in faecal samples fermented with SMO and SMF than in SM. Taken together, these preliminary results indicate a potential role of EPS produced by <i>Leuc. mesenteroides</i> to be used as a functional food ingredient, modulating the gut microbiome as well as increasing the levels of SCFAs.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening of <i>Lactococcus lactis</i> strains with hypoglycemic effects and evaluation of their protective mechanisms against glucose-induced type 2 diabetes in zebrafish.","authors":"Huiying Li, Huijing Chen, Jianquan Kan, Sameh Awad, Amel Ahmed Ibrahim, Zsolt Zalán, Muying Du","doi":"10.1039/d5fo01005e","DOIUrl":"https://doi.org/10.1039/d5fo01005e","url":null,"abstract":"<p><p>Type 2 diabetes mellitus (T2DM) is a major global health challenge, and probiotics represent a potential therapeutic avenue. In this study, three strains of probiotics with α-glucosidase inhibitory activity were screened <i>in vitro</i>, and the inhibitory effect of <i>Pediococcus acidilactici</i> SWU-HY34 (HY34) was the strongest, reaching 35.2%, which was further evaluated <i>in vivo</i> using a hyperglycemia silkworm model and zebrafish diabetes model. Strain HY34 effectively reduced blood glucose levels in diabetic zebrafish (<i>p</i> < 0.05), suppressed the mRNA expression of pro-inflammatory cytokines, tumor necrosis factor alpha (TNF-α), interleukin 1 beta (IL-1β) and interleukin 6 (IL-6), alleviated liver tissue damage (<i>p</i> < 0.05), and also improved lipid profiles by decreasing triglyceride (TG), total cholesterol (TC), and low-density lipoprotein cholesterol levels (LDL) (<i>p</i> < 0.05), while increasing high-density lipoprotein (HDL) levels (<i>p</i> < 0.05). Furthermore, HY34 ameliorated diabetes-induced dyslipidemia and mitigated oxidative stress by enhancing antioxidant enzyme activity. The mechanism by which HY34 improves metabolic health and alleviates diabetes may involve modulating the gut microbiota composition and the production of beneficial metabolites in zebrafish. These results suggest that probiotics, such as HY34, could be further explored for the development of novel hypoglycemic drugs.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of extensively hydrolyzed infant formula on the probiotic and postbiotic properties of <i>Lactobacillus fermentum</i> in an <i>in vitro</i> co-culture model.","authors":"Marta Arroyo-Calatayud, Elisabeth M Haberl, Laura Olivares, Maria Carmen Collado, Monika Schaubeck","doi":"10.1039/d4fo06330a","DOIUrl":"https://doi.org/10.1039/d4fo06330a","url":null,"abstract":"<p><p>Early gut homeostasis is a balance between dietary antigen exposure, gut barrier function, microbiome establishment and orchestration of innate and adaptive immune responses. Imbalances during this early time of development can lead to increased susceptibility to immune reactions like allergy. Especially for infants with a predisposition to allergies and who cannot be exclusively breastfed, there are different human milk substitutes, including hydrolyzed infant formula, which are supposed to prevent allergy-associated mechanisms. The physiologic mechanism beyond the destruction of cow's milk allergenic structures in those formulas are currently not fully understood. Therefore, our aim was to elucidate the impact of hydrolyzed infant formula on intestinal homeostasis and presumed mechanisms behind the beneficial effects. In this study, we used a triple co-culture <i>in vitro</i> model of gut inflammation and homeostasis, including enterocyte-, goblet- and macrophage-like cells in a transwell setup, to assess the effect of extensively hydrolyzed (eHF) infant formula compared to standard cow's milk-based infant formula with intact protein (iPF). These formulas were combined or not with heat-inactivated <i>Limosilactobacillus fermentum</i> CECT 5716 (<i>Lf</i>) to test the effect of probiotic compounds in combination with different types of infant formula (<i>i.e.</i> eHF and iPF) on the intestinal barrier and cytokine production. Under LPS-inflammatory trigger, eHF and eHF + <i>Lf</i> increased mucus production and MUC2 mRNA expression, restored epithelial barrier integrity and increased secretion of regulatory TGFβ, compared to respective controls. These results suggest a beneficial role for eHF, and especially eHF + <i>Lf</i>, in restoring intestinal homeostasis and attenuating pro-inflammatory responses.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144641274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is moderate beer consumption associated with poor dietary and biochemical parameters of nutritional status in adults? A systematic review of observational and interventional studies with meta-analysis.","authors":"Liliana G González-Rodríguez, Iván Cavero-Redondo, Ana M López-Sobaler, Aránzazu Aparicio, Elena Rodríguez-Rodríguez, Viviana Loria-Kohen, María Del Carmen Lozano-Estevan, Esther Cuadrado-Soto, África Peral-Suárez, María Dolores Salas-González, Rosa M Ortega, Laura M Bermejo","doi":"10.1039/d5fo01788b","DOIUrl":"https://doi.org/10.1039/d5fo01788b","url":null,"abstract":"<p><p>The impact of heavy alcohol consumption on health and nutritional status is well-documented, but the effects of moderate beer consumption remain less well understood. This systematic review and meta-analysis examined evidence on moderate beer consumption and dietary and biochemical parameters of nutritional status. It focused specifically on analysing differences between moderate beer consumers and abstainers. A comprehensive search was conducted across four electronic databases (PubMed, SciELO, Web of Science, and SCOPUS) for studies published in English or Spanish from January 2000 to May 2024. Eligible studies included those examining associations between moderate beer consumption and dietary or biochemical parameters related to nutritional status in healthy adults aged 18 years or older. The systematic review included 16 reports (15 independent samples; nine observational and seven interventional), of which five were eligible for meta-analysis. In most studies, the criteria used to classify individuals as moderate consumers exceeded current recommended guidelines. While some minor differences in dietary parameters were noted, overall diet quality appeared broadly similar between moderate beer drinkers and abstainers, according to the results of the meta-analysis. In both groups, diet quality could be improved, as it deviates from the theoretical ideal. Regarding biochemical parameters of nutritional status, our systematic review found insufficient evidence to draw firm conclusions, as many parameters were assessed in single studies only, making a meta-analysis unfeasible. The relationship between moderate beer consumption and nutritional status parameters remains unclear due to limited and inconsistent evidence. Based on the available data, moderate beer consumption may not be associated with poorer overall diet quality compared to abstention. Nevertheless, these findings should be interpreted with caution due to the substantial heterogeneity and methodological limitations of the included studies. Further research is required to achieve a more comprehensive understanding.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144641275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}