Food & Function最新文献

{"title":"Correction: Sinigrin, a bioactive compound from cruciferous vegetables, ameliorates MASLD by activating AMPK/SIRT1/PGC-1α to enhance fatty acid beta-oxidation.","authors":"Yanxin Dong, Wenting Song, Xurui Sun, Xiaohui Wang, Chenyu Zhao, Tong Liu, Yuhan Zhang, Qiu Li","doi":"10.1039/d6fo90085b","DOIUrl":"10.1039/d6fo90085b","url":null,"abstract":"<p><p>Correction for 'Sinigrin, a bioactive compound from cruciferous vegetables, ameliorates MASLD by activating AMPK/SIRT1/PGC-1α to enhance fatty acid beta-oxidation' by Yanxin Dong <i>et al.</i>, <i>Food Funct.</i>, 2026, <b>17</b>, 7716-7733, https://doi.org/10.1039/d6fo00238b.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":"9374-9376"},"PeriodicalIF":6.3,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crude <i>Corbicula fluminea</i> carbohydrate extract attenuates cyclophosphamide-induced immune and intestinal injury in mice in association with gut microbiota remodeling.","authors":"Fan Zhang, Shuo Jia, Xiao Shi, Tiantian Zhao, Liyuan Yun, Lalita Siriwattananon, Min Zhang","doi":"10.1039/d6fo02968j","DOIUrl":"10.1039/d6fo02968j","url":null,"abstract":"<p><p><i>Corbicula fluminea</i> has been increasingly recognized for its nutritional and therapeutic potential. <i>Corbicula fluminea</i> carbohydrate extract (CFPS) is one of the active components of <i>Corbicula fluminea</i>. In this study, two low-molecular-weight oligosaccharide fractions were isolated from crude CFPS for preliminary physicochemical characterization, and the immunomodulatory activity and gut regulatory activities of crude CFPS were investigated, respectively. The results showed that the yield of crude CFPS was 4.97%. Two purified fractions (CFPS-1 and CFPS-2) were obtained with molecular weights of 3.3 × 10³ Da and 0.6 × 10³ Da, respectively. CFPS-1 was composed of glucose (89.1%) and fucose (10.9%), while CFPS-2 contained mannose (10.8%), galactose (4.3%), galacturonic acid (0.7%), and glucose (84.2%). In immunosuppressed mice, crude CFPS administration was associated with ameliorated intestinal barrier damage, upregulated tight junction proteins (ZO-1, occludin, and claudins), and reduced levels of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, and IL-12), which correlated with downregulated TLR4/NF-κB pathway activation. Gut microbiota analysis revealed crude CFPS-associated shifts in microbial composition, including increased Firmicutes and decreased Bacteroidota. Pearson correlation analysis showed positive association between Firmicutes/<i>Lactobacillus</i> abundance and intestinal barrier proteins, and negative correlation with pro-inflammatory cytokines. These associative findings support further investigation of crude CFPS as a functional food candidate, though causal mechanisms remain to be established.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":"9161-9176"},"PeriodicalIF":6.3,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149101180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of moist-heat processing and intrinsic food matrix characteristics on iron bioaccessibility in underutilized green leafy vegetables: a stable isotope-assisted INFOGEST 2.0 assessment.","authors":"Sparsh Sumnirom Subba, Araveti Sumana","doi":"10.1039/d6fo02386j","DOIUrl":"10.1039/d6fo02386j","url":null,"abstract":"<p><p>Underutilized green leafy vegetables (GLVs) are promising plant-based iron sources, yet their nutritional potential is limited by poor iron bioaccessibility. This study investigated iron bioaccessibility in <i>Amaranthus tricolor</i> L., <i>Amaranthus viridis</i> L., and <i>Brassica oleracea</i> var. <i>botrytis</i> using a modified INFOGEST 2.0 <i>in vitro</i> digestion model incorporating stable isotope-assisted (⁵⁷Fe) quantification. Proximate composition, mineral profile, antinutritional factors, intrinsic food matrix characteristics, and the effects of common moist-heat processing were evaluated to identify the determinants of iron bioaccessibility, revealing distinct species-specific differences in the food matrix architecture, chemical functionality, and phenolic composition. Moist-heat processing significantly (<i>p</i> < 0.05) reduced phytate and oxalate contents by up to 78% and 83%, respectively, while increasing the iron solubility from 10.35-16.58% in unprocessed samples to 18.35-26.59% after processing and the iron dialyzability from 4.05-4.42% to 6.60-14.92%. Although boiling produced the greatest proportional improvement in iron bioaccessibility, blanching provided a more favorable balance between iron retention and bioaccessibility and yielded the highest absolute dialyzable iron concentrations across the three GLVs. Iron dialyzability was strongly and negatively correlated with oxalate (<i>r</i> = -0.833, <i>p</i> < 0.001) and phytate (<i>r</i> = -0.732, <i>p</i> = 0.007) and strongly positively correlated with iron solubility (<i>r</i> = 0.858, <i>p</i> < 0.001), indicating that total iron content alone did not predict the proportion of iron rendered bioaccessible during digestion. These findings demonstrate that iron bioaccessibility is determined by the combined influence of intrinsic food matrix characteristics, processing-induced modifications, and reductions in antinutritional factors, providing mechanistic insight into why total iron content alone is a poor predictor of nutritional potential.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":"9264-9286"},"PeriodicalIF":6.3,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149101249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sciadonic acid ameliorates cognitive impairment in APP/PS1 mice with concomitant modulation of gut microbiota and brain metabolism.","authors":"Shujuan Xie, Bo Zheng, Mingqian Li, Bin Zheng, Guoxin Shen, Xingwei Xiang, Lin Chen","doi":"10.1039/d6fo01986b","DOIUrl":"10.1039/d6fo01986b","url":null,"abstract":"<p><p>Sciadonic acid (SCA) is a fatty acid derived from <i>Torreya grandis</i> oil with known anti-inflammatory and antioxidant properties; however, its role in Alzheimer's disease (AD) remains undefined. In this study, oral SCA administration to APP/PS1 transgenic mice significantly improved spatial learning and memory, as assessed by Morris water maze and Y-maze tests. Histological examination revealed reduced neuronal loss, preserved neuropil architecture, and diminished Aβ plaque burden in the hippocampus and cerebral cortex. SCA treatment enhanced antioxidant capacity, as indicated by elevated superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities, alongside decreased malondialdehyde (MDA) and nitric oxide (NO) levels. Furthermore, SCA restored colonic mucosal integrity and suppressed pro-inflammatory cytokines, including tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6). Gut microbiota analysis revealed reversal of dysbiosis, with an increased Bacillota/Bacteroidetes ratio, enrichment of beneficial taxa such as Lactobacillus, and elevated short-chain fatty acid (SCFA) levels. Non-targeted hippocampal metabolomics identified modulation of 16 metabolites, predominantly in taurine and hypotaurine, and pyrimidine pathways. Collectively, SCA administration was associated with cognitive and neuropathological improvements alongside alterations in gut microbiota and hippocampal metabolism.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":"9013-9033"},"PeriodicalIF":6.3,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149101257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enzymatic hydrolysate of nano-selenium biofortified soybean alleviates high-fat diet-induced hyperlipidaemia: associations with improved antioxidant status and modulated gut microbiota.","authors":"Jiayi Duan, Zhi-Hong Zhang, Chi-Tang Ho, Chao Ye, Xianli Gao","doi":"10.1039/d6fo02612e","DOIUrl":"https://doi.org/10.1039/d6fo02612e","url":null,"abstract":"<p><p>Hyperlipidaemia is a major modifiable risk factor for cardiovascular disease and drives increased cardiovascular-related mortality globally. Selenium compounds, notably organic selenium species, exert beneficial effects against hyperlipidaemia and thus represent promising bioactive agents for the maintenance of systemic lipid balance. Herein, EHNBS-30, an economically promising enzymatic hydrolysate derived from soybeans biofortified with 30 mg L^-1 nano-selenium (predominantly enriched with SeMet and MeSeCys), was prepared, and its anti-hyperlipidaemic activities were evaluated in high-fat diet (HFD)-fed Kunming mice. The medium-dose EHNBS-30 group achieved the optimal lipid-regulating outcomes: serum TC, LDL-C and TG decreased by 9.49%, 15.13% and 48.67%, respectively, while HDL-C increased by 40.09% compared with the hyperlipidaemic model group. Additionally, EHNBS-30 significantly elevated the hepatic activities of GSH-Px, SOD and T-AOC, and reduced ALT, AST and ALP levels (<i>p</i> < 0.05), effectively relieving liver damage. Importantly, it also restored gut microbiota and short-chain fatty acid (SCFA) homeostasis in hyperlipidaemic mice, indicating that its lipid-regulating effect was associated with alterations in intestinal microecology. The present work provides insights into the anti-hyperlipidaemic mechanisms of EHNBS-30 and lays a theoretical foundation for the development of novel selenium-enriched lipid-regulating functional foods.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linking the fine structural characteristics of cereal β-glucans to their differential protective effects against colitis.","authors":"Ming Zhang, Buyu Liu, Zhongyu Zuo, Shunqian Xu, Ting Li, Xinxia Zhang, Li Wang","doi":"10.1039/d6fo03379b","DOIUrl":"https://doi.org/10.1039/d6fo03379b","url":null,"abstract":"<p><p>Although cereal β-glucans exert protective effects against experimental colitis, the relationship between their fine structural and physicochemical properties and differential <i>in vivo</i> responses remains unclear. This study directly compared highland barley β-glucan (BBG) and oat β-glucan (OBG), two high-purity mixed-linkage β-(1 → 3)/(1 → 4)-D-glucans, under identical experimental conditions. BBG had a higher cellotriosyl-to-cellotetraosyl (DP3/DP4) ratio than OBG (2.33 <i>vs.</i> 1.51) and a lower weight-average molecular weight. In dextran sulfate sodium (DSS)-induced colitis mice, both β-glucans alleviated clinical signs of disease, while BBG showed greater protection at the tissue and biochemical levels. BBG preserved colon length at 4.88 cm, compared with 4.46 cm for OBG. It reduced myeloperoxidase activity, nitric oxide, and malondialdehyde levels to 1226 U g^-1, 0.42 μmol g^-1, and 78.8 nmol mg^-1, respectively, and fully restored Claudin-1 expression. BBG was also associated with enrichment of <i>Ligilactobacillus</i>, <i>Limosilactobacillus</i>, <i>Romboutsia</i>, and <i>Turicibacter</i> and suppression of <i>Escherichia-Shigella</i>. Fecal metabolomics showed higher levels of selected indole derivatives and taurine-conjugated bile acids, accompanied by lower uric acid and prostaglandin-related inflammatory metabolites. These <i>in vivo</i> differences were accompanied by distinct physicochemical behaviors. BBG showed faster self-aggregation, with a shorter lag time than OBG (112.9 <i>vs</i>. 256.0 min), accompanied by a markedly higher storage modulus (360 <i>vs.</i> 66 Pa). BBG also showed stronger intestinal-phase reassembly under simulated gastrointestinal conditions, approximately threefold greater bile acid retention during dynamic dialysis, and higher DPPH radical-scavenging activity (11.8% <i>vs.</i> 4.8%). Overall, the differential intestinal responses to BBG and OBG were accompanied by distinct physicochemical, microbial, and metabolic profiles, supporting a potential aggregation between cereal β-glucan fine structure, supramolecular behavior, and protective effects against colitis.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive constituent profiling of brown sugar and functional evaluation of an isolated oligosaccharide with iron absorption-promoting and anti-anemia effects.","authors":"Die Cao, Mengyi Yan, Zeyuan Deng, Bingyan Hong, Yadong Miao, Hailing Song, Yifei Li, Liufeng Zheng","doi":"10.1039/d6fo03825e","DOIUrl":"10.1039/d6fo03825e","url":null,"abstract":"<p><p>Brown sugar is a widely consumed non-centrifugal cane sugar with a complex chemical composition, but the constituents responsible for its potential effects on iron homeostasis remain poorly defined. Here, non-targeted UPLC-Q-Exactive MS/MS profiling identified 84 compounds beyond sucrose and glucose, among which 49 were bioactive constituents, including the cyclic peptide cyclo(Pro-Leu), flavonoids, phenolic acids, and itaconic acid. An oligosaccharide present at a relatively high abundance (3.31%, w/w) was isolated through sucrose hydrolysis, macroporous resin adsorption, and 300 Da membrane separation, reaching a purity of over 98%. Combined UPLC-Q-TOF-MS, FTIR, NMR, and differential scanning calorimetry analyses identified it as raffinose. In mice with iron-deficiency anemia, intragastric administration of the purified oligosaccharide restored red blood cell counts, hemoglobin, hematocrit, and serum ferritin, normalized the spleen index and red pulp architecture, and did not affect fasting blood glucose. The purified oligosaccharide also restored splenic ferroportin protein without changing its mRNA level. Molecular docking suggested that it occupies the hepcidin-binding cavity of ferroportin (-8.3 kcal mol^-1), which may competitively prevent hepcidin-mediated ferroportin degradation and thus sustain splenic iron recycling. It also remained largely intact after simulated gastrointestinal digestion. In Ussing chamber experiments, it enhanced intestinal iron transport and was itself transported across the epithelium, pointing to a co-transport process supported by a stable 3 : 1 oligosaccharide-iron complex (ipTM = 0.87). These results suggest that this oligosaccharide, as a functional food ingredient, may support iron homeostasis by coupling ferroportin-mediated splenic iron recycling with chelation-assisted intestinal iron absorption.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":"9206-9221"},"PeriodicalIF":6.3,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149101165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Daphnetin attenuates the early stage of adipogenesis <i>via</i> suppressing mitotic clonal expansion through Nrf2-mediated redox regulation.","authors":"Xiao Chen Shi, Ying Zhang, Yu Tong Wang, Yun Feng Liu, Yi Zhang, Ai Jin","doi":"10.1039/d6fo03104h","DOIUrl":"10.1039/d6fo03104h","url":null,"abstract":"<p><p>Obesity is a major metabolic disorder closely associated with redox imbalance and excessive adipose tissue expansion, yet safe and effective natural compounds targeting early adipogenic events remain limited. Daphnetin, a naturally occurring coumarin derived from edible plants with reported antioxidant properties, has not been fully characterized in the context of adipocyte differentiation and obesity development. Here, we demonstrate that daphnetin significantly attenuates both diet-induced and genetically induced obesity in mice, as evidenced by reduced adiposity and improved glucose homeostasis, without affecting food intake or inducing detectable toxicity. Mechanistically, daphnetin suppresses adipogenesis by targeting mitotic clonal expansion (MCE), a critical early stage of adipocyte commitment. Further investigation revealed that daphnetin effectively modulates intracellular redox homeostasis by reducing reactive oxygen species (ROS) accumulation and promoting nuclear translocation of Nrf2 during adipocyte differentiation. Restoration of oxidative stress by exogenous H₂O₂ abolished the inhibitory effects of daphnetin on MCE and adipogenesis. Consistently, genetic knockdown or pharmacological inhibition of Nrf2 reversed daphnetin-mediated antioxidant signaling and rescued adipogenic progression. Collectively, these findings identify a previously unrecognized Nrf2-ROS-MCE regulatory axis as a key target of daphnetin in adipocyte biology. This study highlights early-stage redox modulation by natural dietary-derived compounds as a promising strategy for preventing obesity and associated metabolic disorders.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":"9192-9205"},"PeriodicalIF":6.3,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149101276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of repetitive pretreatment with isothiocyanates on the stress resistance capacity of RGM1 cells.","authors":"Manami Takeyasu, Shiho Kawaguchi, Akari Ishisaka, Akira Murakami","doi":"10.1039/d6fo02569b","DOIUrl":"10.1039/d6fo02569b","url":null,"abstract":"<p><p>In this study, we investigated the effects of repeated isothiocyanate (ITC) pretreatment on cytotoxicity, cytoprotective gene expression, and chromatin accessibility in rat gastric epithelial RGM1 cells. Cells were pretreated with ITCs at low concentrations (0-2 µM) four times at 48 h intervals, followed by exposure to higher concentrations of ITCs. Repeated benzyl isothiocyanate (BITC) pretreatment significantly attenuated BITC-induced cytotoxicity compared with untreated controls. Moreover, repeated BITC pretreatment (2 µM) markedly increased the mRNA expression levels of cytoprotective genes, including glutathione <i>S</i>-transferase π and heat shock protein 27. Repeated BITC pretreatment also conferred cross-tolerance to low-pH and heat stress conditions. In addition, BITC treatment significantly upregulated the expression of several carbonic anhydrase isoforms associated with intracellular pH homeostasis. A DNase I-based chromatin accessibility assay revealed that repeated BITC pretreatment promoted euchromatin formation at the HO-1 gene locus. Furthermore, euchromatin formation in cytoprotective gene regions was also induced under various stress conditions. These findings suggest that repeated exposure to BITC enhances cellular stress tolerance through the induction of cytoprotective genes and stress-dependent chromatin remodeling.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":"9222-9233"},"PeriodicalIF":6.3,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149101270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Citri reticulatae pericarpium viride</i> attenuates metabolic dysfunction-associated steatotic liver disease by activating PGC-1α-mediated fatty acid oxidation in mice.","authors":"Ting Hu, Ming Zhou, Wen Jiang, Chen Ye, Lijuan Sun, Jichao Liang, Yong Chen","doi":"10.1039/d6fo02111e","DOIUrl":"10.1039/d6fo02111e","url":null,"abstract":"<p><p><i>Citri reticulatae pericarpium viride</i>, a fruit peel from immature <i>Citrus reticulata</i> Blanco known as Qing Pi (QP) in Chinese, is a traditional food ingredient widely employed for culinary flavoring and aroma enhancement. Although QP exerts various metabolic benefits, the impacts and mechanisms of QP on preventing metabolic dysfunction-associated steatotic liver disease (MASLD) remain unclear. Here, we found that QP extracts (extracted with 75% concentrated ethanol and ethyl acetate) not only decreased high-fat diet (HFD)-induced hepatic triglyceride accumulation and oxidative damage, ameliorated glucose intolerance and enhanced insulin sensitivity after oral administration in mice, but also inhibited free fatty acid-induced steatosis and oxidative stress in QP extract-treated primary mouse hepatocytes. Furthermore, we profiled the absorbed components in the serum of mice by UHPLC-Orbitrap MS after oral gavage of QP extracts, and a total of fifteen flavonoid components were identified. By integrating the results of network pharmacology, molecular docking and transcriptomic sequencing, we analyzed the mechanism of action of QP extracts and found that the PGC-1α-PPARα axis and fatty acid oxidation pathway were highly enriched. QP treatment increased fatty acid oxidation (FAO) and the protein expression of p-AMPK, PGC-1α and PPARα, along with increased mRNA expression of key CYP450 enzymes involved in FAO. Pharmacological inhibition of AMPK or PPARα partially abrogated these effects. Therefore, our results highlight QP's potential as a functional food for the management of MASLD.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":"9307-9322"},"PeriodicalIF":6.3,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149101190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}