Food & Function最新文献

{"title":"Co-administration of curcumin forms with supplemental iron: a study of effects on iron absorption and intestinal cellular health","authors":"Marta M. Gámez-Fernández, Helena Tiekou Lorinczova, Stefanie Ho Yi Chan, Satyanarayana Somavarapu, Vinood B. Patel, Sanjoy K. Deb and Mohammed Gulrez Zariwala","doi":"10.1039/D5FO00658A","DOIUrl":"10.1039/D5FO00658A","url":null,"abstract":"<p >Iron deficiency (ID) and iron deficiency anaemia (IDA) are significant global public health issues, with their main line of treatment being oral iron supplementation that often leads to gastrointestinal (GI) adverse effects and early discontinuation. Strategies to improve the efficiency of oral iron supplements and to ameliorate their associated GI effects could help resolve ID and IDA. Curcumin, a potent antioxidant and anti-inflammatory, iron chelating compound from turmeric may mitigate some of these issues. This study aimed to mechanistically assess the interaction of iron (20 and 100 μM) with two different forms of curcumin – native, unformulated curcumin <em>versus</em> a formulated curcumin (HydroCurc®) at 5, 10 and 20 μM, and the consequent effects on iron uptake and intestinal cellular health. Presence of formulated curcumin incremented ferritin levels by 160.5% <em>versus</em> free iron treatment alone (<em>p</em> &lt; 0.0001) in intestinal Caco-2 cells. A greater ferric iron reducing power by the formulated curcumin was observed (<em>p</em> &lt; 0.001). Formulated curcumin also protected against iron-induced permeability of the intestinal barrier (<em>p</em> &lt; 0.05). Our data points to formulated curcumin's ability to limit oxidation of divalent iron as a possible mechanism to explain the greater iron uptake by intestinal cells. This study characterises for the first time the distinct interaction behaviour of curcumin forms with iron and the potential consequences on iron uptake and intestinal health, providing novel insights that may help optimise therapeutic approaches to tackle ID and IDA.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" 14","pages":" 5917-5927"},"PeriodicalIF":5.1,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/fo/d5fo00658a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of human colostrum reveals differential co-occurrence networks of metabolites, microbiota and cytokines in maternal obesity†","authors":"July S. Gámez-Valdez, Karina Corona-Cervantes, Erick S. Sánchez-Salguero, Mario R. Alcorta-García, Claudia N. López-Villaseñor, Rommel A. Carballo-Castañeda, Aldo Moreno-Ulloa, Víctor J. Lara-Díaz, Marion E. G. Brunck and Cuauhtémoc Licona-Cassani","doi":"10.1039/D4FO05637J","DOIUrl":"10.1039/D4FO05637J","url":null,"abstract":"<p >Breastmilk is essential for neonatal development, particularly in seeding the gut microbiota and modulating the immune system. This proof-of-concept study explores the systemic nature of colostrum and the influence of maternal obesity on co-occurrences of colostrum bioactives. Using 16S-rRNA sequencing, untargeted metabolomics, and cytokine quantification, we analyzed co-occurring elements in the colostrum of mothers with normal weight (18.5 &lt; BMI &lt; 25) or obesity (BMI &gt; 30). We identified 5 different co-occurrence networks, characterized by positive correlations of taxonomically related bacteria. Our integrative analysis reveals that <em>Aeromonadaceae</em>, <em>Xanthomonadaceae</em> and <em>Staphylococcaceae</em> negatively correlate with pro-inflammatory cytokines TNF-α, IL-6, and IL-12p70 in the colostrum of mothers with obesity (WO). Additionally, lipid mediators, including 15-HEDE and LysoPC (16:00), were associated with cytokines IL-10 and IL-8 and microbiota taxa <em>Burkholderiaceae</em>, <em>Beijerinckiaceae</em> and <em>Planococcaceae</em> – first reported in the colostrum of mothers WO. Our findings suggest a pervasive regulation of bioactives in the colostrum of mothers WO. This may have implications for distinctive neonatal intestine development.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" 14","pages":" 5900-5916"},"PeriodicalIF":5.1,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/fo/d4fo05637j?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consumption of polyphenols, lipid profile, and markers of lipid peroxidation in patients with COVID-19†","authors":"Margarete Almeida Freitas de Azevedo, Vanessa Brito Lira de Carvalho, Nayara Vieira do Nascimento Monteiro, Maísa Guimarães Silva Primo, Vitória Ribeiro Mendes, Luciana Melo de Farias, Mayara Storel Beserra de Moura, Laís Lima de Castro Abreu, Joyce Lopes Macedo, Poliana Cristina de Almeida Fonseca Viola, Emídio Marques de Matos Neto, Jacenir Reis dos Santos Mallet and Maria do Carmo de Carvalho e Martins","doi":"10.1039/D5FO00571J","DOIUrl":"10.1039/D5FO00571J","url":null,"abstract":"<p > <em>Introduction</em>: COVID-19 has been associated with dyslipidemia and altered markers of lipid peroxidation, which may increase the risk of progression to severe forms of the disease. While viral infections such as COVID-19 can adversely affect lipid profiles, dietary polyphenol intake may improve lipid parameters and mitigate complications. <em>Objective</em>: To investigate the relationship between polyphenol intake, lipid profile, and lipid peroxidation markers in patients with COVID-19. <em>Methods</em>: A cross-sectional study was conducted with 154 adults diagnosed with COVID-19 by real-time RT-PCR, recruited from two primary care units in Teresina, Brazil. Nutritional status and waist circumference were assessed according to the recommendations of the World Health Organization (WHO). Serum concentrations of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c), and triglycerides (TG) were measured to assess lipid profile. Polyphenol intake was estimated using two non-consecutive 24-hour dietary recalls and the Phenol-Explorer 3.6 database. Plasma malondialdehyde (MDA) was assessed <em>via</em> the thiobarbituric acid reactive substances method, and myeloperoxidase (MPO) activity was measured by <em>o</em>-dianisidine oxidation. <em>Results</em>: Most participants were male (55.8%) with a mean BMI of 26.60 kg m<small>⁻²</small>. Polyphenol intake ≥1000 mg day<small>⁻¹</small> was associated with desirable TC levels. The average intake was 1202.59 mg day<small>⁻¹</small>, with flavonoids being the predominant class. Major dietary sources included beans, couscous, and coffee. Flavone intake was inversely correlated with TC and LDL-c levels, while flavanone intake was positively correlated with MPO activity. <em>Final considerations</em>: The consumption of total polyphenols, particularly flavones, was associated with a better lipid profile, suggesting a potential cardiovascular protection and, consequently, a reduction in COVID-19 complications.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" 14","pages":" 5859-5870"},"PeriodicalIF":5.1,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144525535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outstanding Reviewers for Food & Function in 2024","authors":"","doi":"10.1039/D5FO90047F","DOIUrl":"10.1039/D5FO90047F","url":null,"abstract":"<p >We would like to take this opportunity to thank all of <em>Food &amp; Function</em>'s reviewers for helping to preserve quality and integrity in chemical science literature. We would also like to highlight the Outstanding Reviewers for <em>Food &amp; Function</em> in 2024.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" 14","pages":" 5664-5664"},"PeriodicalIF":5.1,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The overlooked impact of background diet and adherence in nutrition trials†","authors":"Javier I. Ottaviani, Hagen Schroeter, Dennis M. Bier, John W. Erdman, Howard D. Sesso, JoAnn E. Manson and Gunter G. C. Kuhnle","doi":"10.1039/D5FO01134E","DOIUrl":"10.1039/D5FO01134E","url":null,"abstract":"<p >Randomised controlled trials in nutrition (RCTN) face unique challenges, including the considerable influence of the background diet and the challenge of assuring intervention adherence by participants. The impact of these factors on the outcome of RCTNs has been difficult to quantify, but nutritional biomarkers represent a valuable tool to address these challenges. Using flavanols as a model dietary intervention and a set of recently validated flavanol biomarkers, we here investigated the impact of background diet and adherence on the outcomes of a subcohort of the COcoa Supplement and Multivitamin Outcomes Study (COSMOS, NCT 02422745). We found that 20% of participants in the placebo and cocoa-extract intervention arms had a flavanol background intake as high as the intervention, and only 5% did not consume any flavanols. Approximately 33% of participants in the intervention group did not achieve expected biomarker levels from the assigned intervention – more than the 15% estimated with pill-taking questionnaires usually implemented in RCTN. Taking these factors into account resulted in a larger effect size for all observed endpoints (HR (95% CI)) estimated using intention-to-treat <em>vs.</em> per-protocol <em>vs.</em> biomarker-based analyses: total cardiovascular disease (CVD) events 0.83 (0.65; 1.07); 0.79 (0.59; 1.05); 0.65 (0.47; 0.89) – CVD mortality 0.53 (0.29; 0.96); 0.51 (0.23; 1.14); 0.44 (0.20; 0.97) – all-cause mortality 0.81 (0.61; 1.08); 0.69 (0.45; 1.05); 0.54 (0.37; 0.80) –– major CVD events 0.75 (0.55; 1.02); 0.62 (0.43; 0.91); 0.48 (0.31; 0.74). These results highlight the importance of taking background diet and adherence into consideration in RCTN to obtain more reliable estimates of outcomes through nutritional biomarker-based analyses.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" 14","pages":" 5733-5743"},"PeriodicalIF":5.1,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12199553/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144493216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Astaxanthin supplement improves clinical outcomes, quality of life, and inflammatory factors in patients with rheumatoid arthritis: a randomized clinical trial","authors":"Ani Grigorian, Ali Tabatabaeyan, Mansour Salesi, Awat Feizi, Ali-Reza Ahmadi and Marzieh Kafeshani","doi":"10.1039/D5FO00949A","DOIUrl":"10.1039/D5FO00949A","url":null,"abstract":"<p >Rheumatoid Arthritis (RA) is a chronic, systemic inflammatory disease that results in joint destruction and progressive disability. This study aimed to determine the effect of astaxanthin (ASX) on clinical outcomes, quality of life, and inflammatory factors in patients with RA. In this randomized, triple-blind, placebo-controlled clinical trial, 60 patients with RA were randomly allocated into two groups and given either 20 mg day<small>⁻¹</small> of ASX supplement in the intervention group (<em>n</em> = 30) or placebo in the control group (<em>n</em> = 30) for 8 weeks. Fasting blood samples were obtained from patients at the beginning and end of the intervention to measure the erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and interleukin-6 (IL-6). Clinical symptoms were also measured, including the pain intensity based on the visual analogue scale (VAS), Disease Activity Score 28 (DAS-28), and Health Assessment Questionnaire (HAQ). In the intervention group compared to the control group after the intervention, DAS-28, HAQ, ESR, and CRP levels were significantly reduced (<em>P</em> &lt; 0.05), and the pain intensity was marginally significantly reduced. The significant differences in DAS-28, HAQ, and ESR levels persisted even after adjusting for baseline values and other covariates. However, no significant differences in the pain intensity and CRP levels were found after controlling for confounding factors (<em>P</em> &gt; 0.05). The IL-6 level did not change in either group by the end of the study, and the difference between the two groups also was not statistically significant (<em>P</em> &gt; 0.05). This study demonstrated the beneficial effects of ASX on some important clinical outcomes, quality of life, and inflammatory factors in patients with RA. Including it as part of their treatment plan could significantly aid in managing their condition.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" 14","pages":" 5850-5858"},"PeriodicalIF":5.1,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144493208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-omic analysis and platelet function distinguish treatment responses to hydroxytyrosol in cardiovascular risk†","authors":"Clara Noguera-Navarro, Kasper T. Vinten, David Auñón-Calles, Carmen Carazo-Díaz, Georges E. Janssens and Silvia Montoro-García","doi":"10.1039/D5FO00874C","DOIUrl":"10.1039/D5FO00874C","url":null,"abstract":"<p >Many phenolic compounds, such as hydroxytyrosol (HT), have been recognized for their antioxidant and cardiovascular (CV) health benefits. To address the efficacy of HT, the present study aimed to identify the relevant mechanisms associated with high-CV risk. Plasma unbiased multi-omics data were compared among two subgroups of high-CV risk patients -HT responders and non-responders. The suppression of platelet reactivity and agonist-induced platelet activation observed after HT intervention were measured by CD61/CD62P expression and apoptotic microparticles with flow cytometry. Microbiota analysis revealed that HT treatment significantly increased and decreased the abundance of <em>Ruminiclostridium</em> sp. and <em>Desulfovidrio</em> sp., respectively. Lipid metabolism and proteomic responses were heterogeneous within the two distinct subgroups, associated mainly with thrombotic and hemostatic signals. The metabolomic analysis further confirmed the differentially expressed metabolites within these two subgroups, highlighting improved glutathione metabolism after HT treatment. The omics datasets integration offers a more comprehensive representation of the glutathione and coagulation pathways affected by the HT treatment. Even though the translation of multi-omics technologies into the clinical landscape is slow, the current interventional study provides an overview of their utility in developing novel therapeutic opportunities to prevent CV diseases, such as suppression of platelet reactivity. Registration number of Clinical Trial: NCT06319417.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" 14","pages":" 5928-5948"},"PeriodicalIF":5.1,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/fo/d5fo00874c?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Protective effect of three glucomannans from different plants against DSS induced colitis in female BALB/c mice","authors":"Liu-Jing Zhang, Xiao-Jun Huang, Xiao-Dan Shi, Hai-Hong Chen, Steve W. Cui and Shao-Ping Nie","doi":"10.1039/D5FO90056E","DOIUrl":"10.1039/D5FO90056E","url":null,"abstract":"<p >Correction for ‘Protective effect of three glucomannans from different plants against DSS induced colitis in female BALB/c mice’ by Liu-Jing Zhang <em>et al.</em>, <em>Food Funct.</em>, 2019, <strong>10</strong>, 1928–1939, https://doi.org/10.1039/C8FO02305K.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" 14","pages":" 5949-5949"},"PeriodicalIF":5.1,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/fo/d5fo90056e?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144482607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flavonoids of Rosa sterilis S. D. Shi improve high-fat diet-induced obesity in mice by inhibiting lipid accumulation and regulating the gut microbiota†","authors":"Rui-Xue Yu, Xu-Lu Luo, Ji-Qiu Wang, Jiao-Jiao Li, Hejiang Zhou, Yong-He Li and Ling-Yan Su","doi":"10.1039/D5FO01469G","DOIUrl":"10.1039/D5FO01469G","url":null,"abstract":"<p >Obesity is a complex disease associated with poor dietary habits and the gut microbiota. <em>Rosa sterilis</em> S. D. Shi contains abundant flavonoids, which have significant antioxidant, anti-inflammatory, and anti-obesity effects. Flavonoids from <em>Rosa sterilis</em> S. D. Shi (FRS) are bioactive compounds with multiple activities. The aim of the present study was to investigate whether and how the FRS can alleviate high-fat diet (HFD)-induced obesity in mice. Our results suggested that there are significant reductions in obesity-related phenotypes after 12 weeks of FRS intervention in HFD-induced mice. FRS significantly reduced weight gain, minimized liver damage, and restored liver and epididymal fat morphology in mice with HFD. Furthermore, FRS increased the population of beneficial bacteria <em>Akkermansia</em>, which helped counteract obesity, thereby improving glucose homeostasis and reducing lipid accumulation by modulating the gut microbiota composition. In conclusion, as a non-toxic and biologically active natural ingredient, FRS has the potential to prevent obesity and related metabolic disorders, and is expected to become a functional ingredient for researching anti-obesity and improving consumer health. This study provides a theoretical foundation and technical support for developing functional FRS products and underscores the importance of FRS in anti-obesity research and the advanced utilization of <em>Rosa sterilis</em> S. D. Shi resources.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" 14","pages":" 5822-5835"},"PeriodicalIF":5.1,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/fo/d5fo01469g?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144482608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polysaccharides from echinoderms: unlocking health benefits and food applications – a review","authors":"Abu Saeid, Deepika Dave and Fereidoon Shahidi","doi":"10.1039/D5FO02177D","DOIUrl":"10.1039/D5FO02177D","url":null,"abstract":"<p >Echinoderms (phylum Echinodermata), including sea cucumbers, sea urchins, and starfish, are found in the marine environment. They have no freshwater or terrestrial representatives and inhabit the entire depth of the ocean. The phylum contains more than 7000 living species. Their bodies contain nutrients like proteins (peptides, collagen, and protein hydrolysates), lipids (polyunsaturated fatty acids), saponins (frondoside A), carotenoids (canthaxanthin and astaxanthin), phenolics (flavonoids and phenolic acids), vitamins, and minerals. Besides, these are the leading sources of unique polysaccharides, such as fucosylated chondroitin sulfate, sulfated fucans, and glycosaminoglycans, which possess a wide range of bioactivities. This review intends to explore the health-promoting properties of these polysaccharides, highlighting their anti-inflammatory, anticoagulant, antioxidant, antitumor, anticancer, and other effects along with their mechanisms of action. Their heterogeneous structural composition and remarkable biological activity make them promising candidates for many applications in the functional foods and nutraceuticals area. Furthermore, this review discusses the major challenges and future prospects of polysaccharides from marine echinoderms, focusing on their extraction, purification, characterization, and structural diversity. In addition, the potential of echinoderm polysaccharides as novel nutrients that can contribute to human health is described and it also highlights the growing desire for natural food products in health promotion and disease risk reduction.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" 14","pages":" 5679-5704"},"PeriodicalIF":5.1,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/fo/d5fo02177d?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}