Food & Function最新文献_第5页

Flaxseed-derived peptide, Ile-Pro-Pro-Phe (IPPF), ameliorates hepatic cholesterol metabolism to treat metabolic dysfunction-associated steatotic liver disease by promoting cholesterol conversion and excretion† 亚麻籽衍生肽，Ile-Pro-Pro-Phe (IPPF)，通过促进胆固醇转化和排泄，改善肝脏胆固醇代谢，治疗代谢功能障碍相关的脂肪变性肝病。

IF 5.1 1区农林科学

Food & Function Pub Date : 2025-03-11 DOI: 10.1039/D4FO04478A

Xingyu Yuan, Yifeng Hou, Narisu Qin, Lu Xiang, Zhe Jiang and Xiaolan Bao

{"title":"Flaxseed-derived peptide, Ile-Pro-Pro-Phe (IPPF), ameliorates hepatic cholesterol metabolism to treat metabolic dysfunction-associated steatotic liver disease by promoting cholesterol conversion and excretion†","authors":"Xingyu Yuan, Yifeng Hou, Narisu Qin, Lu Xiang, Zhe Jiang and Xiaolan Bao","doi":"10.1039/D4FO04478A","DOIUrl":"10.1039/D4FO04478A","url":null,"abstract":"Flaxseed-derived peptide IPPF has been reported to effectively inhibit cholesterol micellization and reduce cholesterol accumulation in vitro. However, its effects on hepatic cholesterol accumulation and related dysfunction-associated steatotic liver disease (MASLD) in vivo, along with the underlying mechanisms and specific molecular targets, remain unclear. This study investigated the impact of IPPF on hepatic cholesterol accumulation to ameliorate MASLD and its potential mechanisms in vivo. Six-week-old male C57BL/6J mice were fed a high-cholesterol, high-fat diet and treated with different doses of IPPF via oral gavage for six weeks. IPPF intervention significantly reduced hepatic cholesterol levels and oxidative stress damage while increasing fecal cholesterol and bile acid excretion. Non-targeted metabolomics analysis revealed that IPPF primarily affected pathways related to ABC transporters and bile acid metabolism. IPPF intake upregulated the mRNA expression of Abcg5/8 and Cyp7a1 in the liver. Molecular docking, dynamics and Surface plasmon resonance (SPR) simulations demonstrated that IPPF binds strongly to ABCG5/8 and CYP7A1, forming stable complexes. Furthermore, cholesterol accumulation and MASLD in HepG2 cells induced by palmitic acid (PA) was alleviated by IPPF, but this effect was partly stopped when CYP7A1 or ABCG5/8 was inhibited. In conclusion, flaxseed-derived peptide IPPF targets CYP7A1 and ABCG5/8, promoting cholesterol conversion and excretion, thereby reducing hepatic cholesterol accumulation and offering a potential nutritional treatment for MASLD. IPPF can be used as a novel dietary cholesterol-lowering functional ingredient. This study provides a scientific basis and new perspective for the development of cholesterol-lowering functional foods and dietary supplements.","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" 7","pages":" 2808-2823"},"PeriodicalIF":5.1,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Apple peels as an edible source of phenolic bioactive compounds with antidiabetic and antiglycation properties 苹果皮作为一种具有抗糖尿病和抗糖化特性的酚类生物活性化合物的可食用来源。

IF 5.1 1区农林科学

Food & Function Pub Date : 2025-03-10 DOI: 10.1039/D4FO05241B

Javier Cano-Lou, Adrián Millán-Laleona, Rares Candrea, Francisco Les, Ana Pina, Giovanni Caprioli and Víctor López

{"title":"Apple peels as an edible source of phenolic bioactive compounds with antidiabetic and antiglycation properties","authors":"Javier Cano-Lou, Adrián Millán-Laleona, Rares Candrea, Francisco Les, Ana Pina, Giovanni Caprioli and Víctor López","doi":"10.1039/D4FO05241B","DOIUrl":"10.1039/D4FO05241B","url":null,"abstract":"Apples (Malus domestica Borkh.) are one of the most consumed fruits around the world with a high production of peels as wastes and by-products. In this work, peels from different commercial and local apple samples are explored as a source of phenolic bioactive compounds that could be directly related to the prevention of type 2 diabetes. Six different cultivars from local and commercial apple samples were processed to obtain the phenolic compounds by ultrasonication of the peels using methanol as the solvent. The phenolic content was explored using the Folin–Ciocalteu assay and the quantification of 37 individual phenolic compounds was carried out by high-performance liquid chromatography coupled with mass spectrometry (HPLC-MS/MS). Cellular viability was determined by performing the MTT assay in Caco-2 cell cultures exposed to the phenolic extracts. Subsequently, the capacity to inhibit α-glucosidase, α-amylase and pancreatic lipase enzymes, as well as antiglycation and antioxidant activities, was evaluated. These apple peel samples were considered a source of phenolic compounds with hyperoside, delphinidin 3,5-diglucoside, chlorogenic acid, phlorizin, epicatechin and procyanidin B2 as the main constituents. All samples neutralized the production of advanced glycation end-products and exhibited antiradical activities in a dose-dependent manner; four samples (Amarilla de Octubre, Manzana Helada, Verde Doncella and Pinova) inhibited α-glucosidase but only the sample known as “Amarilla de Octubre” was successful in inhibiting pancreatic α-amylase. Cytotoxicity was discarded in Caco-2 cell cultures at physiological concentrations considering these extracts as a source of phenolic compounds with antidiabetic, antiglycation and antioxidant properties.","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" 8","pages":" 2947-2958"},"PeriodicalIF":5.1,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/fo/d4fo05241b?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insights from traditional fermented legumes towards the innovation of modern plant-based meat analogues 从传统发酵豆类到现代植物性肉类类似物创新的见解。

IF 5.1 1区农林科学

Food & Function Pub Date : 2025-03-07 DOI: 10.1039/D4FO02035A

Raisa Rudge, Reed A. Nicholson, Colleen Cottrell, Janet Collins, Louwrens C. Hoffman, Jason R. Stokes and Heather E. Smyth

{"title":"Insights from traditional fermented legumes towards the innovation of modern plant-based meat analogues","authors":"Raisa Rudge, Reed A. Nicholson, Colleen Cottrell, Janet Collins, Louwrens C. Hoffman, Jason R. Stokes and Heather E. Smyth","doi":"10.1039/D4FO02035A","DOIUrl":"10.1039/D4FO02035A","url":null,"abstract":"There has been a major growth in the development of plant-based meat alternatives (PBMA) in recent years. However, current PBMA often contain ultra processed ingredients and numerous additives to be able to mimic animal-based meat (ABM) including the meaty (umami) flavour, characteristic firm/chewy structure and juicy mouthfeel. In this review, the potential of ancient fermentation techniques as a minimally processed alternative to ABM and current PBMA are explored. Fermented foods including tempeh, natto, dawadawa and ugba are naturally high in protein and umami flavours. The nutritional, aroma, flavour and techno-functional properties are provided and discussed in the context of ABM and PBMA. The fermented foods have potential to be used as whole foods ingredients, or their constituents can be used as ingredients in plant-based foods. Particularly the umami flavours and high protein content combined with the naturally occurring high water holding capacity (WHC), solubility and other material properties make fermented legume foods suitable candidates for use in high-protein plant-based foods. Understanding the sensory characteristics and material properties generated during legume fermentation and their similarities to ABM can aid in stimulating innovations in food technology to obtain a new generation of less-processed PBMA with limited additives.","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" 7","pages":" 2637-2655"},"PeriodicalIF":5.1,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isorhamnetin ameliorates hyperuricemia by regulating uric acid metabolism and alleviates renal inflammation through the PI3K/AKT/NF-κB signaling pathway† 异鼠李素通过调节尿酸代谢改善高尿酸血症，并通过PI3K/AKT/NF-κB信号通路缓解肾脏炎症。

IF 5.1 1区农林科学

Food & Function Pub Date : 2025-03-07 DOI: 10.1039/D4FO04867A

Xiaoran Kong, Li Zhao, He Huang, Qiaozhen Kang, Jike Lu and Jiaqing Zhu

{"title":"Isorhamnetin ameliorates hyperuricemia by regulating uric acid metabolism and alleviates renal inflammation through the PI3K/AKT/NF-κB signaling pathway†","authors":"Xiaoran Kong, Li Zhao, He Huang, Qiaozhen Kang, Jike Lu and Jiaqing Zhu","doi":"10.1039/D4FO04867A","DOIUrl":"10.1039/D4FO04867A","url":null,"abstract":"Hyperuricemia is a chronic metabolic disease with high incidence, and it has become a severe health risk in modern times. Isorhamnetin is a natural flavonoid found in a variety of plants, especially fruits such as buckthorn. The in vivo hyperuricemia ameliorating effect of isorhamnetin and the specific molecular mechanism were profoundly investigated using a hyperuricemia mouse model in this study. Results indicated that isorhamnetin showed a significant uric acid-lowering effect in mice. Isorhamnetin was able to reduce uric acid production by inhibiting XOD activity. Furthermore, it reduced the expression of GLUT9 to inhibit uric acid reabsorption and enhanced the expression of ABCG2, OAT1, and OAT3 to promote uric acid excretion. Metabolomics analysis revealed that gavage administration of isorhamnetin restored purine metabolism and riboflavin metabolism disorders and thus significantly alleviated hyperuricemia in mice. Furthermore, the alleviating effect of isorhamnetin on hyperuricemia-induced renal inflammation and its specific mechanism were explored through network pharmacology and molecular validation experiments. Network pharmacology predicted that seven targets were enriched in the PI3K/AKT pathway (CDK6, SYK, KDR, RELA, PIK3CG, IGF1R, and MCL1) and four targets were enriched in the NF-κB pathway (SYK, PARP1, PTGS2, and RELA). Western blot analysis validated that isorhamnetin inhibited the phosphorylation of PI3K and AKT and down-regulated the expression of NF-κB p65. It indicated that isorhamnetin could inhibit the PI3K/AKT/NF-κB signaling pathway to reduce the levels of renal inflammatory factors (TNF-α, IL-β and IL-6) and ultimately ameliorate hyperuricemia-induced renal inflammation in mice. This study provides a comprehensive and strong theoretical basis for the application of isorhamnetin in the field of functional foods or dietary supplements to improve hyperuricemia.","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" 7","pages":" 2840-2856"},"PeriodicalIF":5.1,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143661641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary therapy to halt the progression of diabetes to diabetic kidney disease† 饮食疗法阻止糖尿病发展为糖尿病肾病。

IF 5.1 1区农林科学

Food & Function Pub Date : 2025-03-06 DOI: 10.1039/D4FO06011C

Hongtu Hu, Guohua Ding and Wei Liang

引用次数: 0

Myricetin alleviates high-fat diet-induced atherosclerosis in ApoE−/− mice by regulating bile acid metabolism involved in gut microbiota remodeling† 杨梅素通过调节胆汁酸代谢参与肠道微生物群重塑，减轻ApoE-/-小鼠高脂肪饮食诱导的动脉粥样硬化。

IF 5.1 1区农林科学

Food & Function Pub Date : 2025-03-06 DOI: 10.1039/D5FO00374A

Yilong Liu, Ruoqi Wang, Jinren Zhou, Qiang Lyu, Xiaoyong Zhao, Xiaochun Yang, Kunsong Chen, Zhiwei Gao and Xian Li

{"title":"Myricetin alleviates high-fat diet-induced atherosclerosis in ApoE−/− mice by regulating bile acid metabolism involved in gut microbiota remodeling†","authors":"Yilong Liu, Ruoqi Wang, Jinren Zhou, Qiang Lyu, Xiaoyong Zhao, Xiaochun Yang, Kunsong Chen, Zhiwei Gao and Xian Li","doi":"10.1039/D5FO00374A","DOIUrl":"10.1039/D5FO00374A","url":null,"abstract":"Atherosclerosis poses a significant threat to global health. This study aimed to investigate the effects of myricetin (MYR) on high-fat diet (HFD)-induced atherosclerosis in ApoE−/− mice. Our findings demonstrated that MYR treatment significantly reduced the formation of atherosclerotic plaques, particularly at a high dose of 100 mg kg−1 day−1. Additionally, MYR markedly attenuated lipid metabolism disorders in ApoE−/− mice by decreasing body weight, improving serum lipid profiles, and reducing lipid deposition. Analysis of 16S rRNA sequencing revealed that MYR treatment enhanced the abundance of probiotic g_Lachnospiraceae_NK4A136, while it reduced that of obesity-associated genera, including Rikenellaceae_RC9_gut_group and Alistipes. Metabolomic analysis and RT-qPCR tests indicated that MYR upregulated hepatic bile acid biosynthesis, evidenced by increased total bile acid levels and enhanced expression of key enzymes CYP7A1 and CYP8B1, particularly through the classical biosynthetic pathway. Spearman's correlation analysis revealed strong associations between the regulated bile acids and these aforementioned bacteria. Therefore, our results demonstrated that MYR exerts an anti-atherosclerotic effect by modulating the gut-liver axis.","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" 7","pages":" 2737-2749"},"PeriodicalIF":5.1,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/fo/d5fo00374a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of different stages of Maillard reaction in soy: impact on physicochemical properties and immunogenicity of soy proteins† 大豆美拉德反应不同阶段的表征：对大豆蛋白理化性质和免疫原性的影响。

IF 5.1 1区农林科学

Food & Function Pub Date : 2025-03-05 DOI: 10.1039/D4FO04400B

Cresci-Anne Croes, Daniela Briceno Noriega, Harry Wichers, Huub F. J. Savelkoul, Janneke Ruinemans-Koerts and Malgorzata Teodorowicz

{"title":"Characterization of different stages of Maillard reaction in soy: impact on physicochemical properties and immunogenicity of soy proteins†","authors":"Cresci-Anne Croes, Daniela Briceno Noriega, Harry Wichers, Huub F. J. Savelkoul, Janneke Ruinemans-Koerts and Malgorzata Teodorowicz","doi":"10.1039/D4FO04400B","DOIUrl":"10.1039/D4FO04400B","url":null,"abstract":"The Maillard reaction (MR, glycation) frequently occurs during processing of soy-based products widely consumed in Western diets. MR leads to the formation of a number of chemically different structures called Maillard reaction products (MRPs), which include early glycation products and advanced glycation end products (AGEs). AGEs/MRPs were shown to modulate the immune response by interaction with specific receptors expressed on immune cells, such as the receptor for advanced glycation end products (RAGE). However, the structure–function relationship of MRPs formed during soy processing in relation to binding to AGE receptors has not been well studied. The aim of the present study is to characterize the MRPs formed during different heating times of soy proteins (SP) with glucose by analyzing the biochemical changes and to relate them to the functional changes, including binding to AGE receptors and stimulating immune cells. Our results demonstrated time-dependent differences in the biochemical characteristics of glycated SP compared with heated SP, which could be attributed to the different stages of MR and the diversity of MRPs. Moreover, the formation of AGEs over time was positively correlated with binding capacity to AGE receptors. Additionally, stimulating peripheral blood adherent monocytes with glycated SP resulted in increased gene expression levels of pro-inflammatory cytokines (IL-1β, IL-8 and TNF-α) when compared to non-glycated SP, suggesting that the formed AGEs bind to and activate receptors, such as RAGE. Our findings highlight the importance of studying immunomodulation upon processing of SP, which may lead to optimisation of the processing conditions of soy based food products.","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" 6","pages":" 2577-2588"},"PeriodicalIF":5.1,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/fo/d4fo04400b?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143555387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Goat milk oligosaccharides: regulating infant immunity by intervention in the gut microbiota 羊奶低聚糖：通过干预肠道微生物群调节婴儿免疫。

IF 5.1 1区农林科学

Food & Function Pub Date : 2025-03-04 DOI: 10.1039/D5FO00162E

Sibo Liu, Xiaoling Zeng, Jing Li, Wei Li, Yue Gu, Bailiang Li and Jiaqi Wang

引用次数: 0

PA1b-like peptides alleviate mitochondrial dysfunction induced by glucose toxicity through interaction with VDAC1 in β-cells. pa1b样肽通过与β-细胞中的VDAC1相互作用减轻葡萄糖毒性诱导的线粒体功能障碍。

IF 5.1 1区农林科学

Food & Function Pub Date : 2025-03-04 DOI: 10.1039/d5fo00054h

Huizhong Huang, Xinyu Zeng, Liying Zhang, Hongchang Cheng, Kanghong Hu, Xiaoke Shang, Chenguang Yao

{"title":"PA1b-like peptides alleviate mitochondrial dysfunction induced by glucose toxicity through interaction with VDAC1 in β-cells.","authors":"Huizhong Huang, Xinyu Zeng, Liying Zhang, Hongchang Cheng, Kanghong Hu, Xiaoke Shang, Chenguang Yao","doi":"10.1039/d5fo00054h","DOIUrl":"https://doi.org/10.1039/d5fo00054h","url":null,"abstract":"PA1b-like peptides, which are extracted from the seeds of members of the Fabaceae family, display remarkable hypoglycemic and β-cell-protective activities when administered orally. However, the direct targets and mechanisms of action of these peptides in islet β-cells remain unclear. In this study, we found that PA1b-like peptides were mainly distributed in the cotyledon of soybean, rather than in the germ and seed coat. We also identified a direct interaction between PA1b-like peptides and voltage-dependent anion channels (VDACs), with binding energies less than -7 kcal mol-1. Molecular dynamics simulations demonstrated that hydrogen bonding, hydrophobic interactions, and van der Waals forces assist these peptides in forming stable and tight complexes with VDAC1. Moreover, as a member of the PA1B-like peptide family, vglycin (VG) protected mitochondrial function by maintaining the ROS level, ATP production, mitochondrial membrane potential (ΔΨm), intracellular Ca2+ inflow and insulin secretion in β-cells under high glucose stimulation. All these effects were reliant on the direct interaction between VG and VDAC1 in β-cells. This study provides a new strategy for the restoration of mitochondrial function in β-cells under glucose toxicity and establishes a theoretical basis for the treatment of type 2 diabetes (T2D) by PA1b-like peptides.","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143539700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Theaflavin 3′-gallate activates G protein-coupled receptor 55 (GPR55) and enhances GLP-1 secretion via Ca2+/CaMKII/ERK signaling in enteroendocrine STC-1 cells, mitigating postprandial hyperglycemia in mice† 茶黄素3′-没食子酸酯激活G蛋白偶联受体55 (GPR55)，并通过Ca2+/CaMKII/ERK信号通路增强肠内分泌STC-1细胞中GLP-1的分泌，减轻小鼠餐后高血糖。

IF 5.1 1区农林科学

Food & Function Pub Date : 2025-03-03 DOI: 10.1039/D4FO06162D

Kevin Odongo, Naoki Harada, Ryoichi Yamaji, Yoko Yamashita and Hitoshi Ashida

{"title":"Theaflavin 3′-gallate activates G protein-coupled receptor 55 (GPR55) and enhances GLP-1 secretion via Ca2+/CaMKII/ERK signaling in enteroendocrine STC-1 cells, mitigating postprandial hyperglycemia in mice†","authors":"Kevin Odongo, Naoki Harada, Ryoichi Yamaji, Yoko Yamashita and Hitoshi Ashida","doi":"10.1039/D4FO06162D","DOIUrl":"10.1039/D4FO06162D","url":null,"abstract":"The antihyperglycemic effect of black tea is well-known, and theaflavins (TFs) are considered active compounds. It is, however, unclear whether glucagon-like peptide-1 (GLP-1) is involved in the antihyperglycemic effects of TFs. We demonstrate that TFs suppress postprandial hyperglycemia by stimulating GLP-1 secretion in mice. In STC-1 cells, theaflavin 3′-gallate (TF2B), possessing a galloyl group at the 3′-position, showed the strongest effect on GLP-1 secretion among the four TFs. TF2B activated G protein-coupled receptor 55 (GPR55) and was confirmed to bind to the receptor, notably exhibiting the highest binding affinity. Moreover, GPR55 antagonist canceled TF2B-induced GLP-1 secretion. Downstream, TF2B increased intracellular Ca2+ levels and activated the Ca2+/calmodulin-dependent protein kinase II (CaMKII) and extracellular signal-regulated kinases 1/2 (ERK1/2) pathways. Inhibitors of Ca2+ signaling, CaMKII, and ERK pathways abolished TF2B-stimulated GLP-1 secretion. These findings suggest that TF2B from black tea prevents hyperglycemia through GPR55-dependent stimulation of GLP-1 secretion via Ca2+–Ca2+/CaMKII and ERK1/2 pathways.","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" 6","pages":" 2487-2502"},"PeriodicalIF":5.1,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0