Rosa sterilis s.d.s Shi黄酮类化合物通过抑制脂质积累和调节肠道微生物群来改善高脂肪饮食诱导的小鼠肥胖。

IF 5.1 1区 农林科学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Food & Function Pub Date : 2025-06-25 DOI:10.1039/d5fo01469g
Rui-Xue Yu, Xu-Lu Luo, Ji-Qiu Wang, Jiao-Jiao Li, Hejiang Zhou, Yong-He Li, Ling-Yan Su
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引用次数: 0

摘要

肥胖是一种复杂的疾病,与不良的饮食习惯和肠道微生物群有关。石梅含有丰富的黄酮类化合物,具有显著的抗氧化、抗炎、抗肥胖作用。蔷薇黄酮类化合物是具有多种活性的生物活性化合物。本研究的目的是研究FRS是否以及如何减轻高脂肪饮食(HFD)诱导的小鼠肥胖。我们的研究结果表明,在hfd诱导的小鼠中,经过12周的FRS干预后,肥胖相关表型显著减少。在患有HFD的小鼠中,FRS显著减少体重增加,最小化肝损伤,并恢复肝脏和附睾脂肪形态。此外,FRS增加了有益细菌Akkermansia的数量,这有助于对抗肥胖,从而通过调节肠道微生物群组成改善葡萄糖稳态并减少脂质积累。综上所述,FRS作为一种无毒且具有生物活性的天然成分,具有预防肥胖及相关代谢紊乱的潜力,有望成为研究抗肥胖和改善消费者健康的功能成分。本研究为开发功能性FRS产品提供了理论基础和技术支持,强调了FRS在抗肥胖研究和Rosa sterilis s.d.s Shi资源的先进利用中的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Flavonoids of Rosa sterilis S. D. Shi improve high-fat diet-induced obesity in mice by inhibiting lipid accumulation and regulating the gut microbiota.

Obesity is a complex disease associated with poor dietary habits and the gut microbiota. Rosa sterilis S. D. Shi contains abundant flavonoids, which have significant antioxidant, anti-inflammatory, and anti-obesity effects. Flavonoids from Rosa sterilis S. D. Shi (FRS) are bioactive compounds with multiple activities. The aim of the present study was to investigate whether and how the FRS can alleviate high-fat diet (HFD)-induced obesity in mice. Our results suggested that there are significant reductions in obesity-related phenotypes after 12 weeks of FRS intervention in HFD-induced mice. FRS significantly reduced weight gain, minimized liver damage, and restored liver and epididymal fat morphology in mice with HFD. Furthermore, FRS increased the population of beneficial bacteria Akkermansia, which helped counteract obesity, thereby improving glucose homeostasis and reducing lipid accumulation by modulating the gut microbiota composition. In conclusion, as a non-toxic and biologically active natural ingredient, FRS has the potential to prevent obesity and related metabolic disorders, and is expected to become a functional ingredient for researching anti-obesity and improving consumer health. This study provides a theoretical foundation and technical support for developing functional FRS products and underscores the importance of FRS in anti-obesity research and the advanced utilization of Rosa sterilis S. D. Shi resources.

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来源期刊
Food & Function
Food & Function BIOCHEMISTRY & MOLECULAR BIOLOGY-FOOD SCIENCE & TECHNOLOGY
CiteScore
10.10
自引率
6.60%
发文量
957
审稿时长
1.8 months
期刊介绍: Food & Function provides a unique venue for physicists, chemists, biochemists, nutritionists and other food scientists to publish work at the interface of the chemistry, physics and biology of food. The journal focuses on food and the functions of food in relation to health.
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