Food & Function最新文献

{"title":"Caffeic acid stimulates migration and invasion of human trophoblast HTR-8/SVneo cells","authors":"Aleksandra Vilotić, Sanja Kostić, Andrea Pirković, Žanka Bojić-Trbojević, Dragana Dekanski, Svetlana Vrzić-Petronijević and Milica Jovanović Krivokuća","doi":"10.1039/D4FO03699A","DOIUrl":"10.1039/D4FO03699A","url":null,"abstract":"<p >The placenta is a transient organ essential for development of the fetus. Adequate invasion of trophoblast cells, specialized cells of the placenta, is of utmost importance for the establishment and maintenance of healthy pregnancy. Caffeic acid (CA), one of the most abundantly present hydroxycynamic acids in everyday human diet, exhibits various physiological effects such as antioxidant, anti-inflammatory and anticancer activities including an inhibitory effect on migration and invasion of different cancer cell types. There are not many studies on CA safety in human pregnancy. Therefore, the aim of this research was to investigate the potential of CA to affect trophoblast cell function. We evaluated adhesion, migration and invasion of human trophoblast HTR-8/SVneo cells following CA treatment by functional assays. Furthermore, expression of molecular mediators of these processes such as integrin α1, α5 and β1 subunits and matrix metalloproteinase (MMP)-2 and MMP-9 was evaluated at the mRNA level by qPCR and the protein level by cell-based ELISA assay or zymography. Our results showed that 24 h treatment with 10 μM CA stimulated migration and invasion of HTR-8/SVneo cells as well as expression of the integrin α1 subunit. Furthermore, treatment with 100 μM CA stimulated expression of <em>MMP2</em> and <em>MMP9</em> mRNA in the treated HTR-8/SVneo cells as well as secretion of MMP-9. According to obtained results, we can conclude that CA could have the potential to affect processes important for placentation. However, further research is needed to elucidate all aspects of potential CA effects on placental function and pregnancy as a whole.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" 4","pages":" 1603-1614"},"PeriodicalIF":5.1,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plant-based diets and all-cause and cause-specific mortality among patients with cardiovascular disease: a population-based cohort study.","authors":"Xiaohui Liu, Yin Li, Fenglei Wang, Yang Ao, Pan Zhuang, Yu Zhang, Jingjing Jiao","doi":"10.1039/d4fo05107f","DOIUrl":"https://doi.org/10.1039/d4fo05107f","url":null,"abstract":"<p><p>The role of plant-based diets in preventing premature death among patients with cardiovascular disease (CVD) has remained unknown. We aim to explore the association of plant-based dietary patterns with all-cause and cause-specific mortality among patients with CVD. A total of 10 824 participants with CVD at the baseline were followed up in the UK Biobank. We constructed three types of plant-based diet indexes [an overall plant-based diet index (PDI), a healthful PDI (hPDI), and an unhealthful PDI (uPDI)] by assigning different weights to various food groups from web-based 24 h dietary recall questionnaires. The national death registry documented the primary causes of death. The Cox proportional hazards regression models were utilized to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for mortality. Over a median of 9.5 years follow-up, 1273 death cases were ascertained. After multivariable adjustment, PDI had an inverse correlation with all-cause mortality [HR_{T3 <i>vs.</i> T1}: 0.81 (0.70-0.94), <i>P</i>_trend = 0.005] and marginal inverse association with CVD mortality [HR_{T3 <i>vs.</i> T1}: 0.78 (0.61-0.99), <i>P</i>_trend = 0.038], while uPDI displayed a positive correlation with all-cause mortality [HR_{T3 <i>vs.</i> T1}: 1.33 (1.16-1.53), <i>P</i>_trend < 0.001], CVD, and cancer mortality. Additionally, in mediation analyses, serum concentration of C-reactive protein (CRP) accounted for 6.2%, 4.0%, and 5.1% of the relationship between uPDI and all-cause, CVD, and cancer mortality, respectively. No significant associations were detected between hPDI and mortality. Our findings support dietary guidelines that recommend limiting the consumption of unhealthy plant-based foods.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing the power of breast milk: how <i>Lactiplantibacillus plantarum</i> FN029 from rural western China mitigates severe atopic dermatitis in mice through retinol metabolism activation.","authors":"Pengyue Hu, Jin Sun, Ruijuan Gao, Kexin Li, Jiayi Liu, Xiaonan Pan, Zilu Jin, Yuejian Mao, Jing Yang, Renqiang Yu, Ce Qi","doi":"10.1039/d4fo04300f","DOIUrl":"https://doi.org/10.1039/d4fo04300f","url":null,"abstract":"<p><p>Tongwei and Wuxi represent a rural county in western China and an industrialized city in the east, respectively. The study compared breast milk and the corresponding infant gut microbiota from 35 healthy mothers in Tongwei and 28 in Wuxi, uncovering significant differences in microbial alpha and beta diversity. A unique strain, <i>Lactiplantibacillus plantarum</i> FN029, characteristically transmitted from breast milk to the infant gut in Tongwei, was identified. Oral administration of FN029 to weaned BALB/c mice significantly alleviated atopic dermatitis severity caused by calcipotriol and ovalbumin. This reduction was paralleled by a decrease in mast cells and eosinophils in ear tissue and reduced levels of IL-4, IL-12, IL-33, IFN-γ, the IL-4/IFN-γ ratio, and IgE in plasma, along with an upsurge in regulatory T cells in the spleen. RNA sequencing revealed that FN029 activated the retinol metabolism pathway and the Wnt signaling pathway, enhancing immature dendritic cells and regulatory T cells. Metabolomics analysis indicated an increase in retinyl beta-glucuronide, a biomarker of vitamin A reserves. The mRNA expression of retinol-metabolizing enzymes was inversely related to the IL-4/IFN-γ ratio. FN029 also altered ileum microbiota without a direct link to atopic dermatitis improvement. In conclusion, <i>L. plantarum</i> FN029, a probiotic from Tongwei breast milk, fostered T regulatory cell conversion and immune balance by activating the retinol pathway, thereby improving severe atopic dermatitis in mice.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved mechanism of the bioactive compounds isolated from Lactobacillus plantarum TWK10-fermented soymilk in periodontal disease","authors":"Te-Hua Liu, Ya-Hsiang Hsu, Ru-Yun Hsiao, Meng-Chun Cheng, Yann-Lii Leu and Tsung-Yu Tsai","doi":"10.1039/D4FO04049J","DOIUrl":"10.1039/D4FO04049J","url":null,"abstract":"<p >Lactic acid bacteria (LAB) possess immunomodulatory, antioxidant, and antimicrobial properties, making them promising for oral health applications. This study investigated the antibacterial and anti-biofilm activities of TWK10-fermented soymilk extract (TWK10FSEE) against <em>Porphyromonas gingivalis</em> (Pg) and <em>Aggregatibacter actinomycetemcomitans</em> (Aa). TWK10FSEE disrupted the cell membrane integrity, altered membrane permeability, and inhibited the growth of these periodontal pathogens. In a drip-flow biofilm reactor simulating the oral environment, TWK10FSEE regulated biofilm-related gene expression, reduced fimbriae and extracellular polysaccharide production, and retarded biofilm formation. Structural identification revealed succinic acid (SA) and a mixture of daidzein and genistein (MDG) as the primary antimicrobial components. Both SA and MDG effectively inhibited Pg and Aa growth and biofilm formation. TWK10FSEE shows potential as a functional ingredient for periodontal health.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" 4","pages":" 1517-1533"},"PeriodicalIF":5.1,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of pentacyclic triterpenes and polyphenols from table olives in colon and plasma and their chemopreventive effects on 1,2-dimethylhydrazine-induced preneoplastic lesions in rat colon","authors":"Rocío Moreno-González, M. Emília Juan and Joana M. Planas","doi":"10.1039/D4FO04313H","DOIUrl":"10.1039/D4FO04313H","url":null,"abstract":"<p >Table olives are a rich dietary source of pentacyclic triterpenes (PT) and polyphenols (P), many of which have demonstrated significant antiproliferative and proapoptotic activities. This study aimed to evaluate the effect of this food on the early stages of colon carcinogenesis induced by 1,2-dimethylhydrazine (DMH) at 20 mg kg<small>⁻¹</small>. Male Sprague-Dawley rats were administered either water or a suspension of Arbequina table olives (OA; 3.85 g kg<small>⁻¹</small>) by gavage at 10 mL kg<small>⁻¹</small> for 49 days. Each group was then divided into two subgroups that received subcutaneous injections of the carcinogen (DMH+/Olives- and DMH+/Olives+) or the solvent (DMH−/Olives− and DMH−/Olives+) on days 8, 15, and 22. Analysis by LC-MS of AO enabled us to calculate the administered doses of PT (12.38 mg kg<small>⁻¹</small>) and P (4.02 g kg<small>⁻¹</small>) as well as the colon content of these compounds. At the end of the intervention, we found 5.1% of PT and 0.2% of P of the administered dose in the colonic content of the DMH+/Olives+ group. The highest concentrations were for maslinic and oleanolic acids (321 ± 67 and 84.8 ± 14.3 nmol g<small>⁻¹</small>, respectively) followed by hydroxytyrosol (3.31 ± 0.24 nmol g<small>⁻¹</small>). The supplementation with AO reduced aberrant crypt foci by 54.1%, and mucin depleted foci by 35.7% compared to the control group. The daily consumption of table olives exerts chemopreventive activities by reducing preneoplastic intestinal lesions, which might be explained, at least in part, by the significant concentrations of PT and P remaining in the colon.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" 4","pages":" 1588-1602"},"PeriodicalIF":5.1,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/fo/d4fo04313h?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of dietary water intake with body composition and the potential mechanism based on urinary metabolic signatures in Chinese elderly individuals aged 75 years and above†","authors":"Sai Yao, Tianlin Gao, Yajun Liu, Ying Zhou, Zhixuan Zhao, Yinkun Wang, Xincen Wang, Aiguo Ma and Feng Zhong","doi":"10.1039/D4FO05964F","DOIUrl":"10.1039/D4FO05964F","url":null,"abstract":"<p >With the rising global aging rate, elderly nutrition and health issues are major concerns. Current research focuses on nutrients such as protein and vitamins, while there are limited studies on water intake in the elderly. The aim of this study was to assess whether Chinese people aged over 75 years are meeting the recommended adequate intake (AI) for total water intake and its relationship with body composition. This was done by exploring potential mechanisms through the analysis of urinary metabolites. Water intake and dietary status were collected from 456 community seniors aged over 75 years using a 24-hour water intake and dietary record form. Body composition was determined by bioelectrical impedance analysis (BIA). We found that 16.01% of community seniors reached the AI. The protein, fat-free mass (FFM) and skeletal muscle mass (SMM) levels were all increased in the AI group compared to the &lt;AI group. The increase in TWI was associated with increases in body weight and mineral and decreases in the percentage of body fat (<em>β</em> = 0.170, <em>P</em> = 0.032; <em>β</em> = 1.945, <em>P</em> = 0.023; <em>β</em> = −0.125, <em>P</em> = 0.036). TWI was positively correlated with urine volume (UV) (<em>r</em> = 0.560, <em>P</em> = 0.001) and negatively correlated with 24-hour urine osmolality (Uos) (<em>r</em> = −0.378, <em>P</em> &lt; 0.05). Inadequate water intake led to reduced levels of 22 metabolites (<em>e.g.</em>, aspartic acid, <small>L</small>-glutamine, and <small>L</small>-tryptophan). TWI was insufficient among older individuals aged over 75 years in China, impacting their body composition, hydration status, and body metabolism. Therefore, it is suggested to monitor the water intake of elderly individuals and guide them to eat sensibly and drink in moderation to promote their health.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" 4","pages":" 1495-1506"},"PeriodicalIF":5.1,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143121900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal relationship between dietary habits and Alzheimer's disease risk: a univariable and multivariable Mendelian randomization study†","authors":"Yi Huang, Mingyue Zhao, Hangyu Shen, Siqi Chen, Enhao Zhang, Jie Sun and Xiang Gao","doi":"10.1039/D4FO03636K","DOIUrl":"10.1039/D4FO03636K","url":null,"abstract":"<p > <em>Background</em>: The objective of this study was to evaluate the causal link between dietary habits and Alzheimer's disease (AD), utilizing a two-sample Mendelian randomization approach. <em>Methods</em>: In this research, we utilized two-sample Mendelian randomization (MR) analyses in tandem with genome-wide association study (GWAS) data to comprehensively assess the causal link between 17 dietary habits and the risk of AD. To ensure the robustness of the findings, both univariate Mendelian randomization (UVMR) and multivariate Mendelian randomization (MVMR) methods were utilized. All analyses were conducted using inverse variance weighting (IVW) methods, while sensitivity analyses were carried out utilizing the maximum likelihood, MR-RAPS, and MR-Egger methods. <em>Results</em>: In the UVMR analysis, a significant association was observed between the intake of processed meat (OR = 1.26, 95% CI: 1.01–1.59, <em>P</em> = 0.044), poultry (OR = 2.06, 95% CI: 1.18–3.59, <em>P</em> = 0.011), and beef (OR = 1.79, 95% CI: 1.25–2.57, <em>P</em> = 0.002) and an increased risk of AD. Sensitivity analyses revealed that processed meat, poultry, and beef intake consistently exhibited positive associations under various methods. In MVMR analyses, after depression was adjusted, positive associations were found for processed meat intake (OR = 1.376, 95% CI: 1.015–1.864, <em>P</em> = 0.040), poultry intake (OR = 2.174, 95% CI: 1.205–3.922, <em>P</em> = 0.010) and beef intake (OR = 1.428, 95% CI: 0.866–2.355, <em>P</em> = 0.163), which showed significant positive associations or a positive trend. <em>Conclusion</em>: The present research revealed substantial correlations between the consumption of processed meat, poultry, and beef and the risk of AD. This was determined through a comprehensive two-sample Mendelian randomization analysis.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" 4","pages":" 1486-1494"},"PeriodicalIF":5.1,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143077994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of fruit juice extracts on glucose intestinal transporters and antioxidant genes in a Caco-2 and HT29-MTX co-culture cell system†","authors":"Magdalena Köpsel, Tina Kostka, Miriam Rodriguez-Werner and Tuba Esatbeyoglu","doi":"10.1039/D4FO03950E","DOIUrl":"10.1039/D4FO03950E","url":null,"abstract":"<p >In recent years, the interest of consumers in fruit juice extracts as nutraceuticals has increased. Fruits, especially red berries, contain valuable bioactive compounds such as polyphenols. Polyphenols are often associated with anti-oxidant, anti-inflammatory, anti-diabetic, anti-cancer, cardioprotective and gastroprotective properties. However, the relationship between the various effects of fruit juice extracts and their influence on the permeability of the intestinal barrier, as well as their influence on glucose transport across the intestinal membrane, is not known. Therefore, in the present study, anthocyanins and copigments were obtained from 11 fruit juice extracts by XAD7 column chromatography and characterized their health-promoting effects, as well as their influence on the intestinal membrane. Chokeberry, pomegranate and blueberry extracts showed the highest antioxidant activity, but showed incomplete regeneration of the intestinal membrane upon treatment-induced higher permeability. This may depended on the high anthocyanin level of these extracts. Treatments with gojiberry extract, elderberry extract and the copigment fraction of apple achieved the best suitable regeneration of the intestinal barrier. The transcription of epithelial glucose transporters GLUT1 und GLUT2 as well as for the oxidative stress genes catalase (CAT) and superoxide dismutase (SOD) were most effectively reduced by chokeberry extract. To sum up, fruit juice extracts possess high antioxidant potentials and can reduce the expression of antioxidant enzymes and glucose transporters in colon cells. While the glucose uptake may be reduced, the intestinal permeability is increased, which varies due to the extract composition. Therefore, fruit juice extracts need to be fractionated and characterized in more detail to identify the health-beneficial compounds.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" 4","pages":" 1423-1441"},"PeriodicalIF":5.1,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/fo/d4fo03950e?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genistein alleviates rheumatoid arthritis by inhibiting fibroblast-like synovial exosome secretion regulated by the Rab27/nSMase2/Mfge8 pathway","authors":"JiaJia Liu, Jinyang Shi, Sijia Niu, Ziyan Liu, XinHua Cui, Yuli Song, Xudong Tang, Junwen Fan, Hongyue Xu, Wanlu Yu, Mingmei Zhu, Baochun Lu, Ning Liao, Danping Peng, Yang Wang and Lu Yu","doi":"10.1039/D4FO05730A","DOIUrl":"10.1039/D4FO05730A","url":null,"abstract":"<p >Genistein (GEN), the predominant soy isoflavone in legumes, exhibits potential anti-rheumatoid arthritis (RA) effects. This study aims to explore the role of GEN in alleviating RA by regulating exosome secretion and the inflammatory microenvironment through the Rab27/nSMase2/Mfge8 pathway in collagen-induced arthritis (CIA) mice and <em>in vitro</em>. <em>In vivo</em> studies revealed that GEN treatment significantly reduced paw swelling in CIA mice and protected the integrity of knee and ankle joints in CIA mice. GEN supplementation caused a significant decrease in the levels of MMP-9 and pro-inflammatory factors TNF-α, IL-1β and IL-6. GEN also significantly diminished the expressions of β-catenin and exosomal Dvl3 and miR-221-3p in fibroblast-like synoviocytes (FLS). Molecular docking results showed that GEN had strong binding energy with Rab27a, nSMase2 and Mfge8, the key regulators of exosome secretion, respectively, which was confirmed by CETSA and DARTS detection. <em>In vitro</em> mechanism analysis demonstrated that GEN treatment simultaneously downregulated the expression of Rab27a, nSMase2 and Mfge8, and phenotypic analysis verified that GEN prevented the secretion of Alix<small>⁺</small>Hsp70<small>⁺</small>CD63<small>⁺</small> exosomes induced by type II collagen (CII) from FLS. Further analysis showed that GEN inhibited the expression of the Wnt signaling pathway protein β-catenin and exosomal Dvl3 in FLS. Additionally, GEN inhibited CII-induced secretion of MMP-9 and TNF-α, IL-1β and IL-6 in FLS, and GEN also significantly inhibited CII-induced FLS migration. Notably, GEN inhibited the expression of miR-221-3p in FLS exosomes and enhanced osteoblast differentiation and mineralization <em>in vitro</em>. Collectively, this study clarified that GEN alleviates RA by inhibiting the secretion of FLS exosomes regulated by the Rab27/nSMase2/Mfge8 pathway and by inhibiting Dvl3/β-catenin and miR-221-3p.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" 4","pages":" 1407-1422"},"PeriodicalIF":5.1,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/fo/d4fo05730a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143077997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovative approaches to enhancing kombucha through flavour additives: a phytochemical and antioxidant analysis†","authors":"Karolina Jakubczyk, Klaudia Melkis, Dominika Maciejewska-Markiewicz, Anna Muzykiewicz-Szymańska, Anna Nowak and Karolina Skonieczna-Żydecka","doi":"10.1039/D4FO05135A","DOIUrl":"10.1039/D4FO05135A","url":null,"abstract":"<p >This study aimed to determine the phytochemical profile (flavonoids, phenolic acids, caffeine, vitamin C, and acetic acid), antioxidant potential (DPPH, ABTS, and FRAP method), total polyphenol (TPC) and flavonoid (TFC) content, as well as pH of eight commercial green tea-based kombuchas. The beverages were enriched with lemongrass; lavender; liquorice and mint; turmeric and lemon; mango; reishi and chaga; mint, rose, and pomegranate. The highest tested properties were found for kombucha with reishi and chaga (FRAP), with mint, rose, and pomegranate (ABTS), as well as with turmeric and lemon (DPPH, TPC, TFC). Among the identified phenolic acids, <em>p</em>-coumaric acid was found in the highest concentration (kombucha with reishi and chaga), while among the flavonoids – rutin (kombucha with liquorice and mint). Kombucha with reishi and chaga was the richest source of vitamin C, caffeine, and acetic acid. The addition of certain plant materials significantly affects the phytonutrient content of green tea-based kombucha.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" 4","pages":" 1442-1457"},"PeriodicalIF":5.1,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/fo/d4fo05135a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143077998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}