Food & Function最新文献

{"title":"Dietary index for gut microbiota is associated with stroke among US adults†","authors":"Jingjing Liu and Shaoqiang Huang","doi":"10.1039/D4FO04649H","DOIUrl":"10.1039/D4FO04649H","url":null,"abstract":"<p > <em>Aims</em>: Emerging evidence underscores the diet–microbiota–gut–brain axis as vital to brain health. The dietary index for gut microbiota (DI-GM), quantifying diet quality linked to gut microbiota diversity, reflects healthier gut microbiota with higher scores. Therefore, this study was designed to explore the unclear association between DI-GM and stroke. <em>Methods</em>: A cross-sectional analysis was conducted using data from 48 677 participants aged ≥20 years in the National Health and Nutrition Examination Survey (NHANES). Demographic and dietary data were collected, and multivariable weighted logistic regression analysis was performed to evaluate the association between the DI-GM and stroke. Additionally, restricted cubic spline (RCS), subgroup analyses, and receiver operating characteristic (ROC) curve were conducted. <em>Results</em>: In participants aged ≥20 years, the odds ratio (OR) was 0.96 (95% CI: 0.92–1.00, <em>P</em> = 0.075) in the crude model, but after adjustment, the OR was 0.93 (95% CI: 0.89–0.98, <em>P</em> = 0.003), while higher beneficial to gut microbiota scores were consistently associated with lower stroke prevalence with ORs of 0.87 (95% CI: 0.83–0.90, <em>P</em> &lt; 0.001) in the crude model and 0.88 (95% CI: 0.83–0.93, <em>P</em> &lt; 0.001) after adjustment. Among participants aged 20–29 years, no significant association was observed. For those aged ≥30 years, higher DI-GM and beneficial to gut microbiota scores were associated with lower stroke prevalence, with DI-GM showing ORs of 0.93 (95% CI: 0.89–0.97, <em>P</em> &lt; 0.001) in the crude model and 0.93 (95% CI: 0.89–0.98, <em>P</em> = 0.003) after adjustment, and beneficial to gut microbiota scores showing ORs of 0.82 (95% CI: 0.79–0.86, <em>P</em> &lt; 0.001) in the crude model and 0.88 (95% CI: 0.83–0.93, <em>P</em> &lt; 0.001) after adjustment. RCS indicated a linear relationship between DI-GM and stroke. <em>Conclusion</em>: The DI-GM was inversely and linearly associated with stroke prevalence, particularly in adults aged 30 years and above.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" 4","pages":" 1458-1468"},"PeriodicalIF":5.1,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143077995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Inhibitory effects of Atlantic cod (Gadus morhua) peptides on RANKL-induced osteoclastogenesis in vitro and osteoporosis in ovariectomized mice","authors":"Meilian Yang, Di Wu, Shuzhen Cheng, Yu Dong, Chao Wu, Zhenyu Wang and Ming Du","doi":"10.1039/D5FO90008E","DOIUrl":"10.1039/D5FO90008E","url":null,"abstract":"<p >Correction for ‘Inhibitory effects of Atlantic cod (<em>Gadus morhua</em>) peptides on RANKL-induced osteoclastogenesis <em>in vitro</em> and osteoporosis in ovariectomized mice’ by Meilian Yang <em>et al.</em>, <em>Food Funct.</em>, 2022, <strong>13</strong>, 1975–1988, https://doi.org/10.1039/D1FO03696C.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" 4","pages":" 1615-1617"},"PeriodicalIF":5.1,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/fo/d5fo90008e?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143062149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strawberry anthocyanin pelargonidin-3-glucoside attenuated OA-induced neurotoxicity by activating UPRmt†","authors":"Xiao Han, Xinyi Chen, Xiaodong Zheng and Fujie Yan","doi":"10.1039/D4FO04639K","DOIUrl":"10.1039/D4FO04639K","url":null,"abstract":"<p >In this study, network pharmacology analysis revealed that strawberry anthocyanins mainly interfered with lipid metabolism and nerve-related signaling pathways. Pelargonidin-3-glucoside (Pg3G), one of the main anthocyanins in strawberry, was screened as the most effective anthocyanin for attenuating excess lipid accumulation. Moreover, Pg3G decreased lipid levels, relieved oxidative stress, and restored abnormal behavioral activities in <em>Caenorhabditis elegans</em> under oleic acid (OA) exposure. Meanwhile, Pg3G increased the expression of HSP-6 and HSP-60 proteins and activated the mitochondrial unfolded protein response (UPR<small>^mt</small>), while beneficial effects of Pg3G were impaired in the <em>ubl-5</em> knockout strain, suggesting that <em>ubl-5</em> may be a key target for improving OA-induced neurotoxicity. Expressions of neurotransmitter transmission-related genes showed great correlations with genes involved in lipid metabolism and UPR<small>^mt</small>, further explaining the underlying mechanism of Pg3G in neuroprotection. Our findings emphasize the key role of UPR<small>^mt</small> in alleviating OA-induced neurotoxicity of Pg3G, providing a theoretical basis for the research and development of strawberry anthocyanins as a dietary supplement for lipid reduction and treatment of neurodegenerative diseases.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" 4","pages":" 1330-1346"},"PeriodicalIF":5.1,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-omics analysis reveals the anti-fatigue mechanism of BCAA-enriched egg white peptides: the role of the gut-muscle axis.","authors":"Shengrao Li, Jingbo Liu, Qi Yang, Siwen Lyu, Qingwen Han, Menghan Fu, Zhiyang Du, Xuanting Liu, Ting Zhang","doi":"10.1039/d4fo04220d","DOIUrl":"https://doi.org/10.1039/d4fo04220d","url":null,"abstract":"<p><p>Bioactive peptides rich in branched-chain amino acids (BCAAs) are an effective way to alleviate fatigue conditions, but the deep mechanism remains unclear. This study investigated the anti-fatigue effect of branched-chain amino acid-enriched egg white peptides (BEWPs) through the gut-muscle axis by gut bacteria and untargeted metabolomic analyses. The results demonstrated that BEWPs enhanced exercise endurance and strength by also promoting gastrocnemius development in mice. Furthermore, there was a reduction in oxidative stress, inflammatory response, and the accumulation of unexpected metabolites generated under fatigue conditions. The intake of BEWPs increased the abundances of <i>Lactobacillus</i>, <i>Akkermansia</i>, and <i>unclassified_f_Lachnospiraceae</i>, while decreasing the abundance of <i>Bacteroides</i>. BEWPs also regulated the levels of key metabolites in mouse muscles, including L-glutamic acid by arginine biosynthesis and bile secretion pathways. Notably, Spearman's correlation analysis indicated that there was a significant correlation between these altered metabolites, microbial populations, and indicators of fatigue. In summary, our research demonstrated that BEWPs alleviated fatigue through the gut-muscle axis, which provided new insights into fatigue management and prevention.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chrysanthemum extract mitigates high-fat diet-induced inflammation, intestinal barrier damage and gut microbiota disorder†","authors":"Yiwei Yuan, Yu Zhang, Chunli Hu, Zhenyu Wang, Qianqian Xu, Ruili Pan, Xiaojun Li, Mark Christian, Peinan Zhu and Jin Zhao","doi":"10.1039/D4FO04889J","DOIUrl":"10.1039/D4FO04889J","url":null,"abstract":"<p >An effective intervention for obesity without side effects is needed. Chrysanthemum may be the preferred choice due to its influence in the improvement of glycolipid metabolism. This study assessed the efficacy of chrysanthemum and its flavonoids in mitigating high-fat diet (HFD) induced obesity, focusing on the integrity of the intestinal barrier, inflammation, and gut microbiota. Fifty male C57BL/6J mice were divided into 5 groups randomly: normal control (NC), HFD, HFD with chrysanthemum aqueous extract (CM), HFD with a low-dose flavonoid extract of chrysanthemum (FLL), and HFD with a high-dose flavonoid extract of chrysanthemum (FLH). The results showed that after 9 weeks of intervention with CM, FLL and FLH, the body weight and blood lipid levels of mice were reduced. The chrysanthemum treatment regimens down-regulated the gene expression and protein levels of TLR4, MyD88, TRAF6 and NF-κB, upregulated the gene expression levels of ZO-1 and occludin, and decreased the levels of LPS and diamine oxidase (DAO) in the serum. With CM, FLL and FLH, the levels of the inflammatory factors IL-1β, TNF-α, and IL-6 were decreased, and the abundance of pernicious bacteria <em>Lachnoclostridium</em>, <em>Streptococcus</em> and <em>Enterococcus</em> was decreased. Notably, the purified chrysanthemum flavonoid extract showed greater effects as compared to the CM. The study demonstrated that chrysanthemum extracts could achieve anti-obesity effects by strengthening the intestinal barrier function, relieving inflammation and modulating the gut microbial composition.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" 4","pages":" 1347-1359"},"PeriodicalIF":5.1,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human milk oligosaccharides 2′-fucosyllactose and 3-fucosyllactose attenuate ovalbumin-induced food allergy through immunoregulation and gut microbiota modulation","authors":"Siya Wu, Haiqin Chen, Renqiang Yu, Huizhen Li, Jianxin Zhao, Catherine Stanton, R. Paul Ross, Wei Chen and Bo Yang","doi":"10.1039/D4FO04638B","DOIUrl":"10.1039/D4FO04638B","url":null,"abstract":"<p >The prebiotic properties of human milk oligosaccharides (HMOs) and emerging evidence of immunomodulatory effects suggest their potential therapeutic value in allergy management. 2′-Fucosyllactose (2′-FL) has been reported to alleviate food allergies, while the effect of other fucosylated HMOs on food allergy remains unclear. In this study, we assess the effect of two HMOs, 2′-FL and 3-fucosyllactose (3-FL), on symptomatology and immunological responses in an ovalbumin (OVA)-sensitized mouse model of food allergy as well as their influence on gut microbiota. The assessment of allergic symptoms, specific immunoglobulin E (IgE), and related gene expression levels in sensitized mice indicated that 3-FL was as effective as 2′-FL in alleviating food allergy. 2′-FL and 3-FL significantly decreased serum levels of OVA-specific IgE, mouse mast cell protease (mMCP-1) and IL-4 while increasing the levels of IFN-γ. Additionally, 2′-FL and 3-FL down-regulated gene expression of allergy-related cytokines in the small intestine and improved intestinal barrier damage. Furthermore, both 2′-FL and 3-FL treatment positively influenced the gut microbial profiles, in particular by enhancing the proportion of beneficial bacteria such as <em>Lactobacillus</em> and <em>Bifidobacterium</em> and decreasing the percentage of <em>Turicibacter</em> and <em>Lachnospiraceae NK4A136</em> group, thereby modulating the immune system. Therefore, this study can provide insights into 2′-FL and 3-FL to alleviate OVA-induced allergy.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" 4","pages":" 1267-1283"},"PeriodicalIF":5.1,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective association between dietary phytosterol intake and cardiovascular health: an analysis of the UK Biobank cohort†","authors":"Wanning Qiao, Hanxiao Feng, Yi-Feng Zhang, Zhilan Zhang, Jinzhao Yang, Manni Wu, Jiyu Xie, Juan Huang, Tao Zhou and Yang Zhang","doi":"10.1039/D4FO05439C","DOIUrl":"10.1039/D4FO05439C","url":null,"abstract":"<p > <em>Background</em>: Cardiovascular diseases (CVDs) remain a leading cause of morbidity and mortality worldwide, with dietary interventions showing promise in reducing CVD risk factors. Phytosterols (PSs) in plant-based foods may reduce CVD risk by lowering low-density lipoprotein cholesterol. However, the relationship between dietary PS intake and CVD outcomes remains inconclusive. <em>Methods</em>: This study investigated the association between dietary PS intake and CVD outcomes, including coronary heart disease (CHD) and cardiovascular mortality, using a large cohort of 167 209 UK Biobank participants. PS intake was assessed through repeated 24 hour dietary recall data, with participants stratified into quintiles. The Cox proportional-hazards model was used to estimate hazard ratios (HRs) for CVD risk across quintiles of PS intake, adjusting for potential confounders. Restricted cubic splines were used to examine the nonlinear relationship between phytosterol intake and cardiovascular disease risk. Sensitivity and subgroup analyses explored interactions with demographic and lifestyle factors. <em>Results</em>: Higher dietary PS intake was significantly associated with a reduced risk of CVD events, including CHD and cardiovascular mortality. Each 100 mg increase in PS intake was linked to an 8% reduction in CVD risk (HR = 0.92, 95% CI: 0.87, 0.97). Multivariable-adjusted analyses revealed that participants in the highest quintile of PS intake had significantly lower CVD hazard ratios (HR = 0.81, 95% CI: 0.77, 0.84) compared to those in the lowest quintile. Significant inverse associations were also observed for cardiovascular mortality (HR: 0.86, 95% CI: 0.80, 0.94) and CHD (HR: 0.91, 95% CI: 0.84, 0.98). Subgroup analysis highlighted stronger inverse associations in current smokers, individuals with lower body mass index (BMI), and those with moderate to high physical activity levels, with variations observed based on dyslipidemia status. Sensitivity analyses, excluding early events and adjusting for energy intake, confirmed the robustness of the findings. <em>Conclusions</em>: This large cohort study provides evidence supporting the cardioprotective effects of dietary PS intake, particularly for CHD and cardiovascular mortality. Dietary PS may be considered an integral component of heart-healthy diets.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" 3","pages":" 1157-1168"},"PeriodicalIF":5.1,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143021288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro hydrolysis of V-type starch inclusion complexes of alkyl gallates: the controlled two-step release behavior of gallic acid and its beneficial effect on glycemic control†","authors":"Xuan Chen, Xinmiao Wang, Qian Wang, Dong Cai, Jinghan Yu, Beiwei Zhu, Dayong Zhou and Fawen Yin","doi":"10.1039/D4FO05743K","DOIUrl":"10.1039/D4FO05743K","url":null,"abstract":"<p >The heat treatment method was used to synthesize starch inclusion complexes from starch and short-chain alkyl gallates (a typical representative of phenololipids), such as butyl gallate, propyl gallate, ethyl gallate and methyl gallate. In an everted rat gut sac model, HPLC-UV analysis revealed that the released alkyl gallates from inclusion complexes were degraded to produce gallic acid. Gallic acids (0.009455–0.014160 nmol min<small>⁻¹</small>) and alkyl gallates (0.2695–0.9441 nmol min<small>⁻¹</small>) were both able to pass through intestinal membranes. After transmembrane transfer, alkyl gallates could also be hydrolyzed to produce gallic acid (1.947 × 10<small>⁻⁵</small>–2.290 × 10<small>⁻⁵</small> min<small>⁻¹</small>). It was evident that such an inclusion complex demonstrated superior dual sustained-release characteristics for phenolic compounds. Meanwhile, starch inclusion complexes can also slow down starch digestion by raising resistant starch (from 12.2% to 27.2–46.0%) and lowering rapidly digestible starch (from 51.2% to 22.2–51.2%), according to a glucose oxidase–peroxidase analysis. The delayed digestion behavior of starch in inclusion complexes is very beneficial for blood glucose control. Thus, our work effectively established a theoretical foundation for modifying the dual sustained-release behavior of phenolic compounds and the retardation of starch digestion by adjusting the carbon-chain length in starch inclusion complexes.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" 4","pages":" 1550-1561"},"PeriodicalIF":5.1,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioaccessibility of bioactive compounds and associated compounds to the indigestible fraction after in vitro digestion of three dry Capsicum annuum varieties","authors":"Luis Gerardo Medrano-Ruiz, Claudia Celeste Molina-Domínguez, Luisa Alondra Rascón-Valenzuela, Ramon Francisco Dórame-Miranda, Perla Osorio-Díaz, Luis Ángel Medina-Juárez and Maribel Ovando-Martínez","doi":"10.1039/D4FO04168B","DOIUrl":"10.1039/D4FO04168B","url":null,"abstract":"<p >Mexico has a wide variety of dry chilies used in Mexican food preparation because they are spicy, a property related to the bioactive compound named capsaicin. Apart from capsaicin, dry chilies have compounds such as phenolic compounds and tocopherols. Except for phenolic compounds, capsaicin and tocopherol have not been totally assessed to measure their release from the food matrix (bioaccessibility) after <em>in vitro</em> digestion. Therefore, this study is aimed at analyzing the bioaccessibility of phenolic compounds, tocopherols and capsaicinoids after <em>in vitro</em> digestion process of three dry chilies, namely, chiltepin, Colorado, and de Arbol, as well as the bioactive compounds associated with the indigestible fraction (IF). Results indicated that the bioaccessibility values of capsaicinoids were above 80% for all the three chili varieties without showing significant differences. Although these chilies showed high capsaicinoid bioaccessibility values, there were still compounds associated with the IF that could reach the colon and exhibit bioactivity. Regarding phenolic compounds, no differences in the bioaccessibility values were observed; however, there was a major concentration of flavonoids in the IF of the Colorado and de Arbol chilies, which could have a regulatory effect on the colonic microbiome. Regarding the bioaccessibility of α-tocopherol, there was a significant difference between de Arbol and the other two varieties (above 60%). The IF of Colorado chili was a source of α-tocopherol in the colon because it had the lowest bioaccessibility percentage. The overall results demonstrate that dry chilies are a source of bioactive compounds with bioaccessibility values favorable to human health.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" 4","pages":" 1507-1516"},"PeriodicalIF":5.1,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Neuroprotective effects of fermented yak milk-derived peptide LYLKPR on H2O2-injured HT-22 cells","authors":"Yunlong Jiang, Yuan Qi, Xiaoting Liu, Li Fang, Yawen Gao, Chunlei Liu, Dan Wu, Xiyan Wang, Fanrui Zhao, Ji Wang and Weihong Min","doi":"10.1039/D5FO90009C","DOIUrl":"10.1039/D5FO90009C","url":null,"abstract":"<p >Correction for ‘Neuroprotective effects of fermented yak milk-derived peptide LYLKPR on H<small>₂</small>O<small>₂</small>-injured HT-22 cells’ by Yunlong Jiang <em>et al.</em>, <em>Food Funct.</em>, 2022, <strong>13</strong>, 12021–12038, https://doi.org/10.1039/D2FO02131E.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" 3","pages":" 1171-1172"},"PeriodicalIF":5.1,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/fo/d5fo90009c?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143021285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}