Food & Function最新文献

{"title":"Flaxseed powder supplementation in non-alcoholic fatty liver disease: a randomized controlled clinical trial","authors":"Yanyan Tian, Yuhao Zhou, Wang Liao, Jiayue Xia, Qiaosheng Hu, Qing Zhao, Rui Zhang, Guiju Sun, Ligang Yang and Lihua Li","doi":"10.1039/D4FO05847J","DOIUrl":"10.1039/D4FO05847J","url":null,"abstract":"<p > <em>Background</em>: Non-alcoholic fatty liver disease (NAFLD) has become a growing public health problem worldwide, and dietary interventions have important potential in the prevention and treatment of NAFLD. Moreover, previous animal studies have shown that flaxseed has a good improvement effect in animal NAFLD models. <em>Objectives</em>: Assess whether flaxseed powder could improve the liver lipid content in patients with NAFLD. <em>Methods</em>: In this 12-week randomized controlled clinical trial, 50 patients were randomly assigned to the flaxseed group (<em>n</em> = 25) and the control group (<em>n</em> = 25). The flaxseed group received 30 g d<small>⁻¹</small> flaxseed powder orally before lunch or dinner along with health education, while the control group received only health education. The primary outcome was the intrahepatic lipid content assessed by the proton density fat fraction estimated by magnetic resonance imaging, and secondary outcomes were body composition measurements, liver function, and glucolipid metabolism. <em>Results</em>: Patients in the flaxseed group showed significantly lower liver fat content, body fat percentage, obesity index, visceral fat area, serum total bilirubin (TBIL), direct bilirubin (DBIL), indirect bilirubin (IBIL), aspartate aminotransferase (AST), total cholesterol (TC), and triglyceride (TG) levels after a 12-week intervention compared to pre-intervention levels, while serum apolipoprotein A1 (Apo A1) and high-density lipoprotein cholesterol (HDL-C) levels were significantly increased, with all differences being statistically significant (<em>P</em> &lt; 0.05). Analysis of the gut microbiota showed that, at the phylum level, flaxseed intervention significantly increased the abundance of <em>Bacteroides</em> and <em>Actinobacteria</em>, while decreasing the ratio of <em>Firmicutes</em> to <em>Bacteroidetes</em>. At the genus level, the relative abundance of <em>Clostridium_sensu_stricto_1</em>, <em>Parasutterella</em>, <em>Lachnospiraceae_NK4A136_group</em>, <em>Eubacterium_xylanophilum_group</em>, and <em>Bifidobacterium</em> in the gut microbiota of the flaxseed group was significantly higher than that of the control group (<em>P</em> &lt; 0.05), whereas the relative abundance of <em>Coriobacteriaceae_UCG-002</em> was significantly lower than that of the control group (<em>P</em> &lt; 0.05). <em>Conclusions</em>: Flaxseed powder intervention for 12 weeks had the effect of improving liver lipid deposition, liver function, body composition indicators, and lipid metabolism in patients with NAFLD. It also regulated the gut microbiota in NAFLD patients, increasing the abundance of beneficial bacteria while reducing harmful bacteria. This suggested that flaxseed is one of the natural and effective foods for improving NAFLD.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" 4","pages":" 1389-1406"},"PeriodicalIF":5.1,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/fo/d4fo05847j?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lactiplantibacillus plantarum N1 derived lipoteichoic acid alleviates insulin resistance in association with modulation of the gut microbiota and amino acid metabolism†","authors":"Hao Zhong, Yufen Yu, Abdullah, Haoxuan Zhang, Juan Du, Jiangwei Sun, Ling Chen, Fengqin Feng and Rongfa Guan","doi":"10.1039/D4FO06100D","DOIUrl":"10.1039/D4FO06100D","url":null,"abstract":"<p >This study aimed to investigate the effects of heat-killed <em>Lactiplantibacillus plantarum</em> N1 (HK-N1) and lipoteichoic acid (LTA) derived from it on alleviating insulin resistance by modulating the gut microbiota and amino acid metabolism. High-fat diet (HFD)-fed mice were administered live bacteria or HK-N1, and the results demonstrated that HK-N1 significantly reduced epididymal adipocyte size and serum low density lipoprotein-cholesterol, and improved insulin resistance by increasing the YY peptide and glucagon-like peptide levels. HK-N1 also modulated the gut microbiome composition, enhancing microbiota uniformity and reducing the abundance of <em>Ruminococcus</em>, <em>Oscillospira</em> and <em>norank_f_Mogibacteriaceae</em>. Three main active substances obtained from HK-N1 (membrane protein, peptidoglycan, and lipoteichoic acid) were also used to investigate their potential effects in hyperglycemic zebrafish. Only LTA reduced blood sugar and altered the gut microbiome, particularly reducing <em>Aeromonas</em>, which is positively related to hyperglycemia. Untargeted metabolomics revealed that LTA improved vitamin and amino acid metabolism, thereby alleviating metabolic disorders in zebrafish. Collectively, our findings indicate that HK-N1, primarily through LTA, modulated insulin sensitivity by regulating the gut microbiota and amino acid metabolism, offering a potential therapeutic strategy for insulin resistance and type 2 diabetes mellitus.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" 4","pages":" 1371-1388"},"PeriodicalIF":5.1,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enrichment of the major bioavailable molecule glucuronated flavone TMMG in Spinacia oleracea ameliorates cartilage degeneration at a lower dose in ACLT-induced osteoarthritis†","authors":"Geeta Dhaniya, Vallabh Mulay, Priyanka Kothari, Anirban Sardar, Kunal Chutani, Parul, Shikha Verma, Shubha Shukla, Lal Hingorani and Ritu Trivedi","doi":"10.1039/D4FO02128B","DOIUrl":"10.1039/D4FO02128B","url":null,"abstract":"<p > <em>Spinacia oleracea</em> extract (SOE) showed a protective effect on cartilage against osteoarthritis, with one of its compounds, 5,3′,4′-trihydroxy-3-methoxy-6,7-methylenedioxy-flavone4′-glucuronide (TMMG), identified as a major bioavailable molecule with chondroprotective properties. Our recent study aimed to assess the potential of <em>Spinacia oleracea</em> enriched extract (SOEE) containing TMMG in alleviating osteoarthritis symptoms, facilitating easier determination of the human equivalent dose. Using an animal model simulating post-traumatic osteoarthritis, rats underwent anterior cruciate ligament transection (ACLT), with untreated animals serving as controls. Four weeks post-surgery, ACLT rats were randomly assigned for treatment with SOEE orally administered at doses of 10 and 20 mg kg<small>⁻¹</small> d<small>⁻¹</small> for four weeks. A positive control group was administered with crude SOE (125 mg kg<small>⁻¹</small> d<small>⁻¹</small>; ∼1% TMMG). Two days prior to the termination of the animal study, behavioural analysis was done through open field activity and rotarod tests to assess the locomotive activity. Furthermore, data analysis was done through HPLC (high-performance liquid chromatography). Additional investigations corroborated chondroprotective effects <em>via</em> gross morphology of the knee joint, histological assessment of tibial articular cartilage, serum biochemical analysis of cartilage degradation markers, and micro-CT (micro-computed tomography). In conclusion, SOEE at 10 mg kg<small>⁻¹</small> d<small>⁻¹</small> demonstrated superior chondroprotective efficacy when compared to its 20 mg kg<small>⁻¹</small> d<small>⁻¹</small> dosage as well as SOE alone. Further investigation could lead to establishing a human equivalent dose of 1.522 mg kg<small>⁻¹</small> for osteoarthritis treatment.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" 4","pages":" 1469-1485"},"PeriodicalIF":5.1,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143077996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Linolenic acid ameliorates sarcopenia in C. elegans by promoting mitophagy and fighting oxidative stress","authors":"Lu Zhang, Xueyi Zhang, Tao Zhang, Yiwen Guo, Wenjun Pei, Ruijie Liu, Ming Chang and Xingguo Wang","doi":"10.1039/D5FO90010G","DOIUrl":"10.1039/D5FO90010G","url":null,"abstract":"<p >Correction for ‘Linolenic acid ameliorates sarcopenia in <em>C. elegans</em> by promoting mitophagy and fighting oxidative stress’ by Lu Zhang <em>et al.</em>, <em>Food Funct.</em>, 2023, <strong>14</strong>, 1498–1509, https://doi.org/10.1039/D2FO02974J.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" 3","pages":" 1169-1170"},"PeriodicalIF":5.1,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/fo/d5fo90010g?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142996512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lyophilized ash gourd (Benincasa hispida (Thunb.) Cogn.) juice alleviates diet-induced prediabetes in a rat model†","authors":"A. S. Athira, Balan Abhijith, P. K. Sruthi, Achuthan C. Ragavamenon, Ravi S. Lankalapalli and M. V. Reshma","doi":"10.1039/D4FO05327C","DOIUrl":"10.1039/D4FO05327C","url":null,"abstract":"<p >Prediabetes is characterized by elevated blood sugar levels, indicating an increased risk of developing diabetes. This study evaluated the effects of ash gourd (AG), a tropical fruit from the Cucurbitaceae family, on prediabetes, as well as its phytochemical composition. A prediabetic rat model was developed in Sprague-Dawley (SD) rats by administering a high fat diet (HFD) for 16 weeks. This model exhibited reduced pancreatic function, heightened insulin resistance, and decreased insulin sensitivity compared to a standard diet group, leading to hyperglycemia and dyslipidemia, hallmarks of prediabetic conditions. Histological analysis of hepatic tissue revealed macro- and microvesicular fat accumulation and inflammatory changes, supporting these findings. This study highlights the utility of HFD-induced SD rats as a model for prediabetic conditions. Following this, lyophilized ash gourd juice (LAGJ) powder was administered to the prediabetic rat model to assess its potential for reversing prediabetic conditions. LAGJ administration resulted in a significant reduction in fasting blood sugar (FBS) levels, glucose intolerance, and insulin resistance. Additionally, LAGJ significantly mitigated fatty liver changes compared to the prediabetic untreated control (PUC) group. Histological examination of liver tissue in the LAGJ treated group showed a typical architecture similar to that of the normal control group. These findings indicate that LAGJ could be a promising intervention for individuals with prediabetes who are at risk of developing type 2 diabetes and fatty liver disease. Phytochemical analysis of AG pulp revealed the presence of stigmasterol, stigmasteryl β-glucoside, and 6′-<em>O</em>-palmitoyl stigmasteryl β-glucoside.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" 4","pages":" 1534-1549"},"PeriodicalIF":5.1,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation of Morchella esculenta protein and its preventive effect on nonalcoholic fatty liver disease in mice†","authors":"Chen Gao, Peng Liu, Wen Li, Wanchao Chen, Zhong Zhang, Di Wu, Jingjing Huang, Gangqiang Dong and Yan Yang","doi":"10.1039/D4FO04489D","DOIUrl":"10.1039/D4FO04489D","url":null,"abstract":"<p > <em>Morchella esculenta</em> is a valuable edible fungus with multidimensional bioactivities; however, research on <em>M. esculenta</em> protein and its beneficial effects on nonalcoholic fatty liver disease (NAFLD) have been limited. In this study, <em>M. esculenta</em> protein (MEP) with 80.59% protein content was prepared, isolated, and characterized by the complete amino acid composition. The main molecular weight of the protein ranged from 65 to 120 kDa, with 100 kDa being the most dominant band, and it exhibited an alpha helix structure when analyzed by FT-IR and circular dichroism analysis. MEP could regulate body weight, fat accumulation, and alleviate lipid metabolism in adipose tissues in mice with high-fat diet-induced NAFLD. MEP prevented hepatic lipotoxicity, which was reflected in attenuating liver steatosis <em>in vitro</em> and <em>in vivo</em>, thereby regulating the levels of related factors involved in lipid metabolism (<em>e.g.</em>, PPARs, HNF-4, SREBP, FASN, ACC-1, and CD36). Furthermore, it inhibited oxidative stress response, which can be attributed to the activation of the MAPK/PGC-1α pathway. Additionally, MEP exhibited probiotic effects, as demonstrated by the altered gut microbiota composition and improved the intestinal barrier integrity. Thus, this study confirmed the preventive effect of MEP against NAFLD by regulating the gut-liver cross-talk, which provided a theoretical basis for the development and utilization of <em>M. esculenta</em>.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" 3","pages":" 1086-1099"},"PeriodicalIF":5.1,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142996519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical analysis of dried ginger extract and its inhibitory effect and mechanism on Helicobacter pylori and associated ureases†","authors":"Qiang Lu, Jiahao Wang, Ying Tang, Wenna Li and Cailan Li","doi":"10.1039/D4FO04991H","DOIUrl":"10.1039/D4FO04991H","url":null,"abstract":"<p > <em>Helicobacter pylori</em> (<em>H. pylori</em>), one of the most common infectious pathogens in the world, can cause gastritis, digestive ulcers, and even gastric cancer. <em>H. pylori</em> urease (HPU) is a distinctive virulence factor of <em>H. pylori</em> that allows it to be distinguished from other pathogens. Dried ginger is a famous edible and medicinal herb that is commonly used to prevent and treat gastrointestinal tract-related diseases. In this study, phytochemical analysis of the aqueous extract of dried ginger (DGE) and the inhibition of DGE on <em>H. pylori</em> was investigated. Subsequently, we evaluated the inhibitory activity of DGE against enzymes including HPU and jack bean urease (JBU) and determined its potential mechanism of action. UPLC-ESI-MS/MS analysis indicated that a total of 63 compounds including seven glycosides, nine terpenoids, two esters, seven phenols, eight lignans, five phenylpropanoids, and four phenolic acids were identified in DGE. DGE was observed to inhibit the growth of four <em>H. pylori</em> strains (ATCC 43504, NCTC 26695, SS1, and ICDC 111001) with minimum inhibitory concentration (MIC) values spanning the range of 0.05 to 1.50 mg mL<small>⁻¹</small>. Moreover, DGE has higher enzyme inhibitory activity on HPU (IC<small>₅₀</small> = 0.49 ± 0.01 mg mL<small>⁻¹</small>) than on JBU (IC<small>₅₀</small> = 0.54 ± 0.01 mg mL<small>⁻¹</small>). Enzyme inhibitory kinetic analysis revealed that the inhibition type of DGE against HPU was slow-binding and anti-competitive, whereas it was slow-binding and mixed type on JBU. A further mechanism study indicated that the protective effect of sulfhydryl-containing compounds on enzyme activity was significantly better than that of inorganic compounds, indicating that the action site of DGE inhibition of enzyme was the sulfhydryl residue. The results of DTT reactivation experiments showed that the DGE–urease complex was reversible. Furthermore, molecular docking investigation showed that the main components of DGE interacted with sulfhydryl groups and Ni<small>²⁺</small>. In conclusion, DGE effectively inhibited the growth of <em>H. pylori</em> and the activity of its key virulence factor urease. And the in-depth study of the kinetic characteristics and the mechanism of action showed that the active site sulfhydryl group and Ni<small>²⁺</small> might be the targets of urease inhibition by DGE. Our study may provide experimental evidence for the traditional application of dried ginger in the treatment of <em>H. pylori</em>-associated gastric diseases.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" 3","pages":" 1100-1115"},"PeriodicalIF":5.1,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142996518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lactobacillus extracellular vesicles alleviate alcohol-induced liver injury in mice by regulating gut microbiota and activating the Nrf-2 signaling pathway†","authors":"Qianqian Jiao, Jin Liu, Lei Zhou, David Julian McClements, Wei Liu, Jun Luo and Shengfeng Peng","doi":"10.1039/D4FO04364B","DOIUrl":"10.1039/D4FO04364B","url":null,"abstract":"<p > <em>Lactobacillus</em> derived extracellular vesicles (LAB-EVs) are nanosized particles secreted from <em>Lactobacillus</em> during fermentation, and therefore exist universally in fermented foods such as yogurt, pickles, and fermented beverages. In this study, three LAB-EVs were prepared using a simple scalable method, and then their structures, compositions, and biosafety properties were characterized. The protective properties and potential mechanisms of action of the LAB-EVs against alcoholic liver disease were studied. All three LAB-EVs alleviated alcohol-induced liver injury. It was shown by reduction of liver index, histological damage, liver function impairment, inflammation, and liver oxidative status. The results showed that three LAB-EVs positively promoted the diversity of intestinal flora in mice. Additionally, the relative hepatic protein level of Nrf-2, HO-1, and CYP2E1 was also regulated by LAB-EVs. In summary, these facts suggest that the three LAB-EVs can alleviate alcohol-induced liver damage, by positively modulating the intestinal flora and activation of the Nrf-2 signaling pathway. These results may facilitate the understanding of the composition and function of <em>Lactobacillus</em> fermented food and also the development of <em>Lactobacillus</em> fermented functional food.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" 4","pages":" 1284-1298"},"PeriodicalIF":5.1,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143044981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of fructooligosaccharides and Lactobacillus reuteri on the composition and metabolism of gut microbiota in students†","authors":"Xu Xu, Hao Fu, Huihui Quan, Yan Li, Qiaoyun Chen, Daofeng Qu and Xionge Pi","doi":"10.1039/D4FO03763D","DOIUrl":"10.1039/D4FO03763D","url":null,"abstract":"<p >Fructooligosaccharides (FOSs) and <em>Lactobacillus reuteri</em> have shown great potential in treating gastrointestinal diseases by regulating gut microbiota and metabolites. However, the synergistic effect between these two remains unclear. In this study, an <em>in vitro</em> fermentation model was constructed to investigate the regulatory effects of FOSs and <em>L. reuteri</em> on the gut microbiota of healthy student populations. After 24 hours of fecal fermentation, the results indicated that the experimental group added with FOSs had increased relative abundances of <em>Bifidobacterium</em> and <em>Lactobacillus</em>, while it exhibited lower relative abundances of <em>Escherichia</em>–<em>Shigella</em> and <em>Bacteroides</em>. Conversely, the groups added with <em>L. reuteri</em> had higher relative abundances of <em>Bacillus</em> and <em>unclassified_c_Bacilli</em>. The results of microbial metabolism revealed that the addition of FOSs produced a large amount of acetic acid, but reduced the contents of propionic acid, butyric acid, isobutyric acid, and isovaleric acid, along with reducing the production of H<small>₂</small>, H<small>₂</small>S and NH<small>₃</small>. In contrast, the addition of <em>L. reuteri</em> had no significant effect on metabolism. Compared to the single additions, the combination of FOSs and <em>L. reuteri</em> had its advantages and had a more balanced microbial structure and metabolic regulation similar to the addition of FOSs alone. Additionally, correlation analysis revealed a negative correlation between gas production and <em>Bifidobacterium</em>, <em>Lactobacillus</em>, and <em>Bacillus</em>, and a positive correlation with <em>Escherichia</em>–<em>Shigella</em> and <em>Bacteroides</em>. Moreover, the formation of acetic acid was positively correlated with <em>Bifidobacterium</em> and negatively correlated with <em>Escherichia</em>–<em>Shigella</em>. These findings demonstrated that the combination of FOSs and <em>L. reuteri</em> can effectively synergistically regulate the fecal microbiome of students. This study can provide a theoretical reference for the precise development of functional foods. However, the regulatory mechanisms need further in-depth investigation.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" 4","pages":" 1562-1575"},"PeriodicalIF":5.1,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human gut microbiota-fermented asparagus powder protects human epithelial cells from injury and inflammation†","authors":"Sumudu Rajakaruna, Brant Bandow, Sergio Pérez-Burillo, Beatriz Navajas-Porras, José Ángel Rufián-Henares, David R. Cool, Kwang-Jin Cho and Oleg Paliy","doi":"10.1039/D4FO03504F","DOIUrl":"10.1039/D4FO03504F","url":null,"abstract":"<p >Dietary consumption of green asparagus has been associated with several health benefits. These beneficial properties are attributed to the presence of many bioactive compounds in asparagus, including saponins, phenolics, flavonoids, as well as dietary fiber mostly comprising fructans and inulins, which are prebiotics capable of supporting the growth of beneficial members of gut microbiota. In this study, we used the <em>in vitro</em> Human Gut Simulator system to assess the fermentation of oro-gastro-intestinally digested asparagus powder by the human gut microbiota. Microbial community composition differed between communities grown on the asparagus digest and on the Western diet derived medium. Asparagus supported beneficial <em>Ruminococcus</em> but also hydrogen sulfide producing members of Desulfovibrionaceae. Fermentation of asparagus released more antioxidants into the environment compared to the Western diet medium, and supernatant of asparagus-grown cultures protected cultured human epithelial cells against damage and inflammation. We thus showed that asparagus powder has potential to be used as a functional food, offering protection against intestinal damage and inflammation – effects mediated by the gut microbiota.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" 3","pages":" 1060-1071"},"PeriodicalIF":5.1,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142996517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}