ACS Sensors最新文献

{"title":"Photothermal Paper-Based Microfluidic Analytical Device Integrated with Carbon Nanomaterials and Molecularly Imprinted Polymers for Sensitive Perfluorooctanesulfonate Quantification.","authors":"Kawin Khachornsakkul,Thithawat Trakoolwilaiwan,Ruben Del-Rio-Ruiz,Elliot Friesen,Wijitar Dungchai,Tapparath Leelasattarathkul","doi":"10.1021/acssensors.5c00940","DOIUrl":"https://doi.org/10.1021/acssensors.5c00940","url":null,"abstract":"The global prevalence of perfluoroalkyl and polyfluoroalkyl substance (PFAS) contamination highlights the need for sensitive, accessible, simple, and cost-effective analytical tools. In this article, we present the first photothermal-based microfluidic paper-based analytical device (PT-μPAD) for the detection of perfluorooctanesulfonate (PFOS), one of the most widespread PFAS, in various matrices, including water, food, and human samples. By integration of a molecularly imprinted polymer (MIP) with carbon dots (CDs), the device achieves selective and sensitive PFOS monitoring by measuring the temperature change on the μPAD sensor. Additionally, the detection signal is rapidly obtained via a wireless near-field communication (NFC) system embedded in a portable and user-friendly platform. Under optimization, the developed sensor delivers a linear range between 1.5 and 7.0 pg mL-1 (R2 = 0.9989) and a detection limit (limit of detection (LOD)) of 7.0 fg mL-1. Our developed sensor also exhibits high selectivity, with no observed interferent effects. The method also demonstrates remarkable accuracy and precision for PFOS quantification across real-world samples, achieving recovery percentages of 92.5-110.0% and the highest relative standard deviation (RSD) of 7.3%. Correspondingly, the results obtained using our method are comparable to those from the high-performance liquid chromatography-mass spectrometry (HPLC-MS/MS) method, as confirmed by a 95% confidence level in the t test analysis. Therefore, this sensor is well-suited for PFOS monitoring across various sample matrices, offering key advantages, such as simplicity, cost-effectiveness, portability, and ease of use by unskilled operators. Overall, this approach can be extended to the detection of other target molecules through MIP modification, showing its versatility. Furthermore, this concept holds great potential for broader applications, including medical point-of-care (POC) diagnostics and prognostics, on-site environmental analysis, and food safety.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"33 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144533533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highly Selective Hybrid InSe-Graphene for NO₂ Gas Sensing with High Humidity Tolerance.","authors":"Jyayasi Sharma, Frank Güell, Mubdiul Islam Rizu, Dalal Fadil, Eduard Llobet","doi":"10.1021/acssensors.4c03521","DOIUrl":"https://doi.org/10.1021/acssensors.4c03521","url":null,"abstract":"<p><p>p-type pristine InSe, pristine graphene, and the corresponding hybrid InSe-graphene gas sensor that is highly selective to NO₂ have been developed. These materials are produced at an environmentally friendly temperature of 35 °C by the Liquid Phase Exfoliation (LPE) technique. Then their deposition was performed on alumina transducers for achieving chemoresistive gas sensors. X-ray diffraction (XRD), field-emission scanning electron microscopy (FESEM), high-resolution transmission electron microscopy (HRTEM), photoluminescence (PL), and Raman spectroscopy were used to analyze the materials. The multilayered crystalline structure is revealed by HRTEM. Studies on gas-sensing properties showed that the response of the hybrid InSe-graphene sensor to 1 ppm of NO₂ is three times higher than the one of the pristine graphene sensor, whereas the pristine InSe sensor was not responsive. While under dry conditions, the response to NO₂ (1 ppb) was 3.41%, under humid conditions (RH 50%), the responsiveness was significantly increased to 6.16% and to 14.42% for sensors operated at 150 and 250 °C, respectively.</p>","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144525401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements in Fluidic Ionic Devices: Implications for Neuromorphic Integrated Circuit Design.","authors":"Honglin Lv, Rui Liu, Yin Zhang","doi":"10.1021/acssensors.5c01063","DOIUrl":"https://doi.org/10.1021/acssensors.5c01063","url":null,"abstract":"<p><p>Biological brains that use ions as signaling carriers exhibit powerful computing and learning capabilities. Inspired by this, ion-based neuromorphic devices have gained widespread attention. As a neuromorphic device, the fluidic ionic memristor can simulate not only synaptic plasticity but also the transduction of chemical-electrical signals because of unique ions biocompatibility. Furthermore, ionic circuits provide a versatile platform for constructing neural networks, demonstrating significant potential for simulating biologically inspired computations. However, ion-based neuromorphic computational circuits are still in their infancy, and there is an urgent need for comprehensive guidance on their development. In this perspective, we first describe the development of ionic devices and the working principle of fluidic ionic memristors as well as their application in the simulation of biological synapses systematically. We then summarize the construction of neuromorphic computing integrated circuits in a fluidic environment. Finally, a series of solutions to the challenges faced by ionic devices involving performance indexes and the design of neuromorphic circuits are also discussed.</p>","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144525400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polymer Coating for the Long-Term Storage of Immobilized DNA.","authors":"Xingcheng Zhou,Jessica Slaughter,Smah Riki,Chao Chi Kuo,Ariel Furst","doi":"10.1021/acssensors.5c00937","DOIUrl":"https://doi.org/10.1021/acssensors.5c00937","url":null,"abstract":"As healthcare systems worldwide demand early disease detection and personalized medicine, electrochemical biosensors stand out as a promising technology to meet these demands due to their sensitivity, selectivity, and rapid response. Specifically, DNA-based electrochemical biosensors are versatile and have been used to identify biomarkers of various infectious diseases. However, there is a significant gap between laboratory-scale proof-of-concept systems and commercially viable technologies. Commercialization of such sensors faces many challenges, with one of the most important being the stability and shelf life of the immobilized DNA. Surface-associated DNA faces thermal degradation, structural changes, and oxidation of tethering thiol groups, which causes DNA stripping from the surface. Currently, technology to support the long-term storage of these sensors at ambient temperatures is limited. Here, we report a novel method to preserve DNA in electrochemical biosensors through the application of a protective coating of poly(vinyl alcohol) (PVA). We show that with our PVA coating, the shelf life of dried, DNA-functionalized electrodes at ambient temperature is a minimum of 2 months. We further demonstrate that the protective capabilities of PVA extend to temperatures as high as 65 °C and that the biological relevance of the assay is not impacted by the coating. Our simple approach to DNA protection supports our understanding of how the electrode interfaces with biomolecules and facilitates biosensor scaling and commercialization.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"33 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144520913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-Functional Monomer-Based Molecularly Imprinted Light-Addressable Photoelectrochemical Platform for Multichannel Detection of Molecules with Various Sizes.","authors":"Shengli Cao,Gang Xiao,Wenjin Liao,Boxiang Zhao,Shuqi Xie,Zhenguo Liu,Wei Chen,Zhao Yue","doi":"10.1021/acssensors.5c01306","DOIUrl":"https://doi.org/10.1021/acssensors.5c01306","url":null,"abstract":"The emerging molecularly imprinted polymer (MIP) films, combined with various transducers, have drawn significant attention for biomarker detection. Currently, MIP films exhibit inferior performance and a limited detection variety range when detecting macromolecules because MIP films are unable to form effective cavities for macromolecule detection and their poor electrical and optical properties do not meet the requirements of transducers. To address these problems, MIP films were fabricated by dual-functional monomers (o-phenylenediamine and pyrrole) in this work. MIP films were further integrated with a photoelectrochemical (PEC) transducer based on gold nanoclusters (AuNCs) to develop MIP-PEC sensors. Experimental results indicated that dual-functional monomers significantly enhanced the form of effective cavities with controllable number and orientation, electrical properties, and optical properties of the MIP film. Furthermore, the introduction of the MIP film onto AuNCs improved the stability of the MIP-PEC sensor and formed a heterojunction to enhance the photoelectric property of the sensor. Then, the sensing mechanism was elucidated with structural competitive binding, including size, shape, and binding sites, through cross-detection of PD-L1, CYFRA21-1, and cortisol with MIP-PEC sensors of varying cavity sizes. Finally, MIP-PEC sensors were expanded to a light-addressable MIP-PEC platform to detect PD-L1, CYFRA21-1, cortisol, and 4-methoxyphenylacetic acid in blood samples from patients with nonsmall cell lung cancer for early diagnosis and treatment evaluation. Therefore, the combination of dual-functional MIP films with PEC transducers represents a promising strategy for the high-sensitivity detection of molecules with various sizes, particularly for macromolecules. The light-addressable MIP-PEC platform provides a novel approach for the multichannel detection of multiple biomarkers.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"105 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144520916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Dongrui Tu,&nbsp;Yiwei Tang,&nbsp;Yiyang Huang,&nbsp;Minyi Tang,&nbsp;Linrong Li,&nbsp;Yu Li,&nbsp;Mengdi Lu,&nbsp;Zewei Luo* and Yixiang Duan,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"10 6","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":8.2,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acssensors.5c00044","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144488948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Yong Yang,&nbsp;Wei Huang,&nbsp;Xiaoling Lei,&nbsp;Yuan Ai,&nbsp;Can Sheng,&nbsp;Dongliang Zhang,&nbsp;Shizhao Wang,&nbsp;Fang Dong* and Sheng Liu*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"10 6","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":8.2,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acssensors.5c00592","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144488976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Hyun-Kyung Um,&nbsp;Eunseo Noh,&nbsp;Chaehwa Yoo,&nbsp;Hyang Woon Lee,&nbsp;Je-Won Kang,&nbsp;Byoung Hoon Lee* and Jung-Rok Lee*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"10 6","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":8.2,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acssensors.4c03602","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144488982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Xiuwei Li,&nbsp;Yuyang Wang,&nbsp;Xue Liu,&nbsp;Jingzhu Li,&nbsp;Jian Wu,&nbsp;Min Zeng*,&nbsp;Jianhua Yang,&nbsp;Nantao Hu,&nbsp;Hao Zhu,&nbsp;Lin Xu* and Zhi Yang*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"10 6","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":8.2,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acssensors.5c00584","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144488985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Chunyan Huang,&nbsp;Peng Wang*,&nbsp;Hongsen Niu*,&nbsp;Ningji Gong* and Yang Li,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"10 6","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":8.2,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acssensors.5c00565","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144488986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}