ACS Sensors最新文献_第2页

Wearable Wireless Patch with Unidirectional Microfluidic Chamber for Enzyme-Free Glucose Monitoring in Sweat 带单向微流控室的可穿戴无线贴片用于汗液中无酶葡萄糖监测

IF 8.9 1区化学

ACS Sensors Pub Date : 2025-05-28 DOI: 10.1021/acssensors.5c00592

Yong Yang, Wei Huang, Xiaoling Lei, Yuan Ai, Can Sheng, Dongliang Zhang, Shizhao Wang, Fang Dong, Sheng Liu

{"title":"Wearable Wireless Patch with Unidirectional Microfluidic Chamber for Enzyme-Free Glucose Monitoring in Sweat","authors":"Yong Yang, Wei Huang, Xiaoling Lei, Yuan Ai, Can Sheng, Dongliang Zhang, Shizhao Wang, Fang Dong, Sheng Liu","doi":"10.1021/acssensors.5c00592","DOIUrl":"https://doi.org/10.1021/acssensors.5c00592","url":null,"abstract":"Conventional glucose sensors based on biological enzymes are prone to interference in complex environments, particularly for wearable sweat monitoring. Although synthetic nanozymes exhibit higher stability, they often require highly alkaline conditions to achieve optimal performance, limiting their application in wearable devices. To address this challenge, this study presents a novel enzyme-free wearable wireless patch capable of real time, in situ monitoring of glucose concentrations in sweat. The device employs a microfluidic channel to collect sweat, where solid NaOH is dissolved to create the required alkaline environment. Subsequently, the sweat enters a detection chamber, where two-dimensional nickel-based organic framework nanoflowers modified with gold nanoparticles (Au-NPs/Ni-BDC NFs) serve as the sensing layer, enabling highly sensitive and stable glucose detection. Integrated temperature and pH sensors provide real time calibration to ensure measurement accuracy, while a Tesla valve prevents the backflow of alkaline solution to the skin. A custom-designed smartphone application facilitates real-time analysis of sweat glucose levels during physical activity, by managing signal acquisition, processing, and wireless communication. Through in situ pretreatment of sweat within the microfluidic channel and cooperative operation with a sensor array, this study effectively overcomes key challenges in enzyme-free glucose sensing for wearable devices. The proposed system demonstrates significant potential for future health monitoring, particularly for real-time tracking during exercise and daily activities.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"35 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-Powered Strain Sensing via Ion Physisorption at PVC Ion Gel─Metal Interfaces 聚氯乙烯离子凝胶-金属界面上离子物理吸附的自供电应变传感

IF 8.9 1区化学

ACS Sensors Pub Date : 2025-05-28 DOI: 10.1021/acssensors.5c00632

Dokyun Kim, Chang-Soo Han

{"title":"Self-Powered Strain Sensing via Ion Physisorption at PVC Ion Gel─Metal Interfaces","authors":"Dokyun Kim, Chang-Soo Han","doi":"10.1021/acssensors.5c00632","DOIUrl":"https://doi.org/10.1021/acssensors.5c00632","url":null,"abstract":"Self-powered strain sensors are crucial for wearable technology and low-power applications, where continuous operation with minimal energy is essential. Conventional sensors typically require external power, leading to bulky designs, limited battery life, and frequent maintenance, which hinder seamless integration into wearable devices. This study introduces an ion physisorption-based self-powered strain sensor (IPSS) enabling stable, strain-induced voltage measurements without external power. The IPSS leverages the physical adsorption of [EMIM] cations in a PVC ion gel onto electrode surfaces, generating a measurable voltage difference under strain. Potential of zero charge measurements confirmed selective ion adsorption based on electrode work functions, validating the IPSS’s operating mechanism. Notably, the IPSS demonstrated a broad operational range of 0–200% strain with a linear response of 2.3 mV/% in the low-strain range (0–40%), highlighting its precision for wearable applications. Using the IPSS’s stable, self-powered signal, a CNN-based gesture recognition model achieved 92% accuracy with just 0.00507 GFLOPs, showing the sensor’s potential for low-power, high-accuracy applications in wearable and resource-limited environments.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"7 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Programmable Transcriptional–Translation Active Sensors for miRNA-Responsive Gene Imaging and Theranostics in Mammalians 用于哺乳动物mirna反应性基因成像和治疗的可编程转录翻译主动传感器

IF 8.9 1区化学

ACS Sensors Pub Date : 2025-05-28 DOI: 10.1021/acssensors.5c01016

Xiaorui Shi, Chong Hu, Bin Guo, Chuanxian Zhang, Yaru Xue, Zeping Yang, Fu Wang

{"title":"Programmable Transcriptional–Translation Active Sensors for miRNA-Responsive Gene Imaging and Theranostics in Mammalians","authors":"Xiaorui Shi, Chong Hu, Bin Guo, Chuanxian Zhang, Yaru Xue, Zeping Yang, Fu Wang","doi":"10.1021/acssensors.5c01016","DOIUrl":"https://doi.org/10.1021/acssensors.5c01016","url":null,"abstract":"Synthetic gene circuits are logical circuits constructed by various biological elements based on engineering principles. However, the majority of current synthetic gene circuits are modulated through exogenous factors or endogenous inhibitory substances, which results in redundant structures and low efficiency, thereby greatly limiting their application scenarios. In this study, we developed a miCU sensor system comprising the Gal4-VP16 gene element, which enables real-time targeted monitoring of miR-9 and miR-124a during neural differentiation through transcriptional–translation two-step active regulation with a relatively low background signal. Additionally, the functional gene was replaced by P21 through the programmability of miCU, thereby achieving miRNA-mediated cell cycle arrest and suppression of cell migration in tumor cells. Furthermore, by strategically substituting the target miRNA with miR-155 and concurrently introducing the therapeutic gene Nrf2 into the miCU system, the integration of disease diagnosis and treatment in lipopolysaccharide (LPS)-induced acute liver injury (ALI) mouse models has been successfully achieved. Our study presented a programmable miRNA-responsive gene regulation platform, which may offer a robust tool for precise diagnosis and treatment in disease settings.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"57 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficient ppt-Level H2S Gas Sensor Based on YSZ and α-Fe2O3 Nanofoam Sensing Electrode 基于YSZ和α-Fe2O3纳米泡沫传感电极的高效pt级H2S气体传感器

IF 8.9 1区化学

ACS Sensors Pub Date : 2025-05-27 DOI: 10.1021/acssensors.5c00956

Xidong Hao, Xiangli Meng, Tianling Yu, Zihao Wang, Yinglin Wang, Shanfu Sun, Pengfei Cheng, Yintang Yang, Qianyong Yang

{"title":"Efficient ppt-Level H2S Gas Sensor Based on YSZ and α-Fe2O3 Nanofoam Sensing Electrode","authors":"Xidong Hao, Xiangli Meng, Tianling Yu, Zihao Wang, Yinglin Wang, Shanfu Sun, Pengfei Cheng, Yintang Yang, Qianyong Yang","doi":"10.1021/acssensors.5c00956","DOIUrl":"https://doi.org/10.1021/acssensors.5c00956","url":null,"abstract":"Herein, porous α-Fe2O3 nanofoam was successfully synthesized and used as a sensing electrode to fabricate a yttria-stabilized zirconia (YSZ) mixed-potential hydrogen sulfide (H2S) sensor for real-time monitoring of hazardous H2S gas. The sintering temperature was adjusted to modify the microstructure of the sensing electrode material and its electrochemical reaction intensity to H2S, enhancing the sensor’s performance. Among the tested materials, α-Fe2O3 nanofoam sintered at 800 °C exhibited the highest electrochemical catalytic activity toward H2S in electrochemical tests, suggesting its suitability as a sensing electrode material for YSZ-based H2S sensors. The sensor incorporating α-Fe2O3 nanofoam sintered at 800 °C achieved the highest response of −273 mV to 10 ppm of H2S at 625 °C. Moreover, this sensor exhibited a low detection limit of 100 ppt and, within the H2S concentration range of 0.5–10 ppm, a high sensitivity of −180.3 mV/decade, outperforming other reported YSZ-based H2S sensors. Furthermore, this fabricated sensor exhibited excellent repeatability, selectivity, and long-term stability, indicating its potential for industrial safety early warnings and precise environmental monitoring. This study provides a valuable reference for designing porous sensing electrode materials and enhancing the sensing performance of mixed-potential gas sensor.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"25 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel Flexible Organic Photoplethysmogram Sensor for Continuous Cardiovascular Monitoring. 用于心血管连续监测的新型柔性有机光电容积图传感器。

IF 8.9 1区化学

ACS Sensors Pub Date : 2025-05-27 DOI: 10.1021/acssensors.5c00552

Shubham Kumar,Rashi Kedia,Arti Bisht,Amit Soni,Ruchi K Sharma,Sanjay Yadav,Asit Patra,Sanjay K Srivastava,Ashok Kumar

{"title":"Novel Flexible Organic Photoplethysmogram Sensor for Continuous Cardiovascular Monitoring.","authors":"Shubham Kumar,Rashi Kedia,Arti Bisht,Amit Soni,Ruchi K Sharma,Sanjay Yadav,Asit Patra,Sanjay K Srivastava,Ashok Kumar","doi":"10.1021/acssensors.5c00552","DOIUrl":"https://doi.org/10.1021/acssensors.5c00552","url":null,"abstract":"A flexible organic photodetector (OPD) has been developed for a flexible organic photoplethysmography sensor (FOPS) designed to monitor vital cardiovascular parameters such as pulse rate, respiratory rate, blood pressure, and pulse rate variability. This device is fabricated on a flexible substrate, utilizing a blend of PCDTBT and PC71BM as the active layer. The FOPS demonstrates excellent absorption properties across the visible spectrum, which is essential for capturing high-quality arterial pulse signals, known as photoplethysmogram (PPG). Optoelectronic characterization revealed a high response time and an impressive on/off current ratio, enabling the accurate detection of microfeatures within the PPG signal. We successfully utilized the device to monitor PPG signals in both reflection and transmission modes, employing green (530 nm) and red (630 nm) light sources, respectively. The recorded PPG signals were further analyzed to measure cardiovascular parameters. The device also demonstrates the ability to measure blood pressure using two techniques: a cuff-based method in conjunction with the oscillometric waveform (OMW) and a cuff-less technique utilizing an artificial neural network approach. These results highlight the FOPS's potential for integration into wearable medical technology, offering continuous, real-time cardiovascular monitoring in a user-friendly and noninvasive manner.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"57 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144146212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic Self-Assembly Enabled Highly Ordered Mesoporous WSe2/WO3 Crystalline Heterostructures for Rapid NO2 Sensing at Room Temperature. 协同自组装使高有序介孔WSe2/WO3晶体异质结构在室温下快速感应NO2。

IF 8.9 1区化学

ACS Sensors Pub Date : 2025-05-26 DOI: 10.1021/acssensors.5c00955

Zhenliang Li,Yuan Ren,Yujian Rao,Rui Ma,Ao Xu,Zejun Han,Tuo Zhang,Xueqiong Cui,Qiongfeng Shi,Li Tao

{"title":"Synergistic Self-Assembly Enabled Highly Ordered Mesoporous WSe2/WO3 Crystalline Heterostructures for Rapid NO2 Sensing at Room Temperature.","authors":"Zhenliang Li,Yuan Ren,Yujian Rao,Rui Ma,Ao Xu,Zejun Han,Tuo Zhang,Xueqiong Cui,Qiongfeng Shi,Li Tao","doi":"10.1021/acssensors.5c00955","DOIUrl":"https://doi.org/10.1021/acssensors.5c00955","url":null,"abstract":"A rapid and highly sensitive detection of harmful gas molecules is crucial in artificial olfaction (electronic nose), which plays a significant role in areas such as environmental monitoring and healthcare. However, it remains a significant challenge to construct highly sensitive molecular sensors with fast response at room temperature due to the limitations in structures and properties (e.g., porosity, crystallinity, and carrier mobility) of the sensing materials. Herein, this study proposes a facile method to enable highly crystalline mesoporous WSe2/WO3 (m-WSe2/WO3) semiconductor heterostructures through controllable interfacial self-assembly of polyoxometalate (POM) clusters and amphiphilic block copolymers combined with a thermal-assisted conversion process. It allows uniform pore size, open channels, large specific surface area, highly crystalline framework, and abundant transition metal chalcogenide/metal oxide heterojunction interfaces. The m-WSe2/WO3-based chemiresistive semiconductor sensor achieves efficient detection of NO2 at room temperature, including ultrafast response (5 s), high selectivity (SNO2/Sgas > 5), high sensitivity (62.5%@50 ppm), low detection limit (50 ppb), and long-term stability (>30 days). Thanks to the synergistic improvement of sensing dynamics between mesostructure and heterojunction, such a few-second response time has been reduced by half of the reported values in most existing counterparts based on two-dimensional materials. Our work paves the way for the application of high-performance and cost-effective molecular sensors in artificial olfaction, electronic skins, and wearable integrated circuits at room temperature.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"11 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144146220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Next-Generation Wearable/Implanted Sensors Based on Fiber Optic and Its Application: From in Vitro to in Vivo. 基于光纤的下一代可穿戴/植入式传感器及其应用：从体外到体内。

IF 8.9 1区化学

ACS Sensors Pub Date : 2025-05-26 DOI: 10.1021/acssensors.5c00044

Dongrui Tu,Yiwei Tang,Yiyang Huang,Minyi Tang,Linrong Li,Yu Li,Mengdi Lu,Zewei Luo,Yixiang Duan

{"title":"Next-Generation Wearable/Implanted Sensors Based on Fiber Optic and Its Application: From in Vitro to in Vivo.","authors":"Dongrui Tu,Yiwei Tang,Yiyang Huang,Minyi Tang,Linrong Li,Yu Li,Mengdi Lu,Zewei Luo,Yixiang Duan","doi":"10.1021/acssensors.5c00044","DOIUrl":"https://doi.org/10.1021/acssensors.5c00044","url":null,"abstract":"Wearable sensors are significant for health status, diagnosing diseases, and adjusting postoperative interventions to monitor the physiological information on humans continuously. The first generation of wearable sensors has gained rapid growth in medical health for monitoring physical parameters. Recently, emerging fiber optics (FOs) with small diameters have been attached to desired locations of the human epidermis or fabrics for monitoring physiological change activity. Because of its strong soft tissue affinity and excellent biocompatibility, FO has been injected into human skin, blood vessels, and the brain for sensing of biological parameters. The detection of FO has been extended, ranging from physical parameters to chemical and biological parameters. Also, the application of FO has shifted from wearable sensors in vitro to implanted sensors in vivo. Thus, FO is expected to launch a milestone contribution to next-generation wearable/implanted sensors. Based on the success, this review focuses on wearable and implantable FO-based sensors. The three main design strategies of single point, distributed, and FO array were profiled. The significant application of the detection of the physical, chemical, and biological parameters was discussed. The opportunities and challenges of wearable/implantable FO-based sensors were highlighted to promote their development for commercial applications.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"34 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Performance Evaluation of a Miniaturized, Toothbrush-Shaped Ultrasound Transducer for Periodontal Imaging. 一种用于牙周成像的小型牙刷形超声换能器的性能评价。

IF 8.9 1区化学

ACS Sensors Pub Date : 2025-05-26 DOI: 10.1021/acssensors.5c00521

Suhel Khan,Pei Yun Tsai,Baiyan Qi,Casey Chen,Jesse V Jokerst

{"title":"Performance Evaluation of a Miniaturized, Toothbrush-Shaped Ultrasound Transducer for Periodontal Imaging.","authors":"Suhel Khan,Pei Yun Tsai,Baiyan Qi,Casey Chen,Jesse V Jokerst","doi":"10.1021/acssensors.5c00521","DOIUrl":"https://doi.org/10.1021/acssensors.5c00521","url":null,"abstract":"A miniature, high-frequency ultrasound transducer could have major value in dentistry and periodontal care. Still, most current ultrasound transducers use large form factors, which limit access to molars and premolars. This paper reports a compact side-facing, toothbrush-shaped ultrasound transducer with a portable handle for real-time imaging of anatomical structures. The 128-element, high-frequency (40 MHz) response of the transducer was utilized to characterize the axial and lateral resolution at 2-16 mm depths, as well as the impact of angulation. The mean axial and lateral resolutions were 49 ± 15 μm and 149 ± 21 μm, respectively. The impact of angulation on imaging quality was evaluated. An acceptable angular window of -15° to +20° in the roll and pitch axes was found to produce correct anatomical information. Angulation in the yaw axis loses control over the reference plane. The transducer soft tissue-related measurements (gingival thickness and gingival height) correlated with the gold-standard clinical measurements. The correlation coefficients, r = 0.7243 (p = 0.0001) for gingival thickness and 0.7886 (p < 0.0001) for gingival height, show a strong correlation with the clinical method. The Bland-Altman plot compared ultrasound imaging and manual periodontal probe measurements indicated a bias of -0.002 mm and -0.0263 mm, respectively, for gingival thickness and height, with a 95% limit of agreement. The miniaturized high-frequency transducer offers optimal adaptation to the tooth surface with a wide range of working axes, providing high-resolution and detailed ultrasound images for real-time scans of the periodontium.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"103 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144146219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trace Detection of Nitrogen Dioxide via Porous Tin Dioxide Nanopods with High Specific Surface Area and Enhanced Charge Transfer. 利用高比表面积和增强电荷转移的多孔二氧化锡纳米脚检测痕量二氧化氮。

IF 8.9 1区化学

ACS Sensors Pub Date : 2025-05-26 DOI: 10.1021/acssensors.5c00584

Xiuwei Li,Yuyang Wang,Xue Liu,Jingzhu Li,Jian Wu,Min Zeng,Jianhua Yang,Nantao Hu,Hao Zhu,Lin Xu,Zhi Yang

{"title":"Trace Detection of Nitrogen Dioxide via Porous Tin Dioxide Nanopods with High Specific Surface Area and Enhanced Charge Transfer.","authors":"Xiuwei Li,Yuyang Wang,Xue Liu,Jingzhu Li,Jian Wu,Min Zeng,Jianhua Yang,Nantao Hu,Hao Zhu,Lin Xu,Zhi Yang","doi":"10.1021/acssensors.5c00584","DOIUrl":"https://doi.org/10.1021/acssensors.5c00584","url":null,"abstract":"Nitrogen oxides, particularly nitrogen dioxide (NO2), contribute significantly to environmental pollution and pose serious risks to public health. Therefore, detecting even low concentrations of NO2 is significant for effective environmental monitoring and public health protection. Existing NO2 gas sensors, however, have limitations such as low sensitivity, insufficient selectivity, and slow response and recovery times. In this work, we synthesized tin-based metal-organic framework nanorods using phthalic acid as the ligand and subsequently fabricated porous tin dioxide (SnO2) nanopods through high-temperature calcination. The resulting SnO2 nanopods feature one-dimensional rod-like SnO2 frameworks filled with plenty of SnO2 nanoparticles. This micronanostructure exhibits a large specific surface area (299.8 m2/g) and a large pore size (30.8 nm), which facilitates the adsorption, diffusion, and surface reactions of NO2. The sensors demonstrate excellent performance in detecting NO2, with a response value of 64 to 1 part per million (ppm) NO2 at a working temperature of 250 °C, a response time of 15 s, and a recovery time of 20 s. Moreover, the SnO2 nanopod sensors show a wide detection range from 10 parts per billion to 100 ppm, good repeatability, long-term stability, and reliable NO2 detection at low concentrations even under high humidity conditions (90% relative humidity).","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"1 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144146221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineered Antifouling Peptides with Sarcosine Branches for Robust Electrochemical Detection of the HER2 Biomarker in Real Biological Samples. 具有肌氨酸分支的工程防污肽用于真实生物样品中HER2生物标志物的鲁棒电化学检测。

IF 8.9 1区化学

ACS Sensors Pub Date : 2025-05-25 DOI: 10.1021/acssensors.5c00082

Hao Zhou,Mingjun Shi,Wenhao Yang,Ning Song,Xiliang Luo

{"title":"Engineered Antifouling Peptides with Sarcosine Branches for Robust Electrochemical Detection of the HER2 Biomarker in Real Biological Samples.","authors":"Hao Zhou,Mingjun Shi,Wenhao Yang,Ning Song,Xiliang Luo","doi":"10.1021/acssensors.5c00082","DOIUrl":"https://doi.org/10.1021/acssensors.5c00082","url":null,"abstract":"In complex biological matrices, the nonspecific adsorption phenomena occurring on the surfaces of electrochemical biosensors represent a considerable challenge for the precise detection of targets in heterogeneous biological samples. Furthermore, the presence of protein hydrolases in biofluids also affects the stability of biosensing devices utilizing natural proteins or peptides. It is therefore imperative to develop sensing devices capable of effectively minimizing such effects in real biological samples. Herein, we engineered a sarcosine branch-chain peptide (SBCP) with a strong antifouling capability to avoid biofouling and enhanced stability to resist hydrolysis by proteases. The peptide is composed of three sections: an anchoring sequence (CPPPP), an antifouling sequence (EK(Sar)EK(Sar)EK(Sar)EK(Sar)), and a recognition sequence (HLTVSPWY). An electrochemical biosensor was developed through the electrodeposition of poly(3,4-ethylenedioxythiophene) (PEDOT) incorporated with poly(norepinephrine) (PNE) on an electrode surface, followed by the electrodeposition of gold nanoparticles and the self-assembly of SBCP. The biosensor constructed using the SBCP containing a specific recognizing peptide sequence for the cancer biomarker human epidermal growth factor receptor 2 (HER2) was capable of sensitively detecting target HER2, within the concentration range of 1.0 pg mL-1 to 1.0 μg mL-1 and with a limit of detection of 0.37 pg mL-1. Moreover, the biosensor demonstrated antifouling ability and the capacity to accurately detect the target in human serum, exhibiting a high degree of concordance with the assaying results of ELISA kits. These findings suggest that the biosensor based on the engineered peptides possesses promising potential for practical applications.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"33 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0