ACS Sensors最新文献

{"title":"Long-Term Stable Reference Electrodes with High-Pressure Tolerance and Salinity-Independence","authors":"Yunwen Shen, Yuankai Lu, Huixiu Mao, Dan Zhao, Wei-Jun Cai, Yiwen Pan","doi":"10.1021/acssensors.4c02952","DOIUrl":"https://doi.org/10.1021/acssensors.4c02952","url":null,"abstract":"The reference electrode’s performance is essential for ensuring the accuracy of electrochemical sensors in marine environments. Yet, the many existing reference electrodes can exhibit sensitivity to salinity variations, potentially leading to inaccuracies in the measurement process. Herein, we have designed a reliable solid-state reference electrode by introducing SiO_<i>x</i>-stabilized 1-methyl-3-octylimidazolium bis(trifluoromethyl sulfonyl)imide ([C₈mim⁺] [Ntf₂^–]) into a P(VdF-<i>co</i>-HFP) matrix with a SPEEK/[C₈mim⁺] [Ntf₂^–] coated Ag/AgCl as substrate. The SPEEK/[C₈mim⁺] [Ntf₂^–] coating protects the AgCl substrate, and the incorporation of SiO_<i>x</i> improves the compatibility of the IL with the polymer matrix, thereby increasing the electrode’s resistance to interference and extending its long-term stability and lifespan. The developed reference electrode showed a stable and rapid response, with potential variations of less than 0.7 mV across various salinity solutions, including practical seawater, lake water, and their mixture samples. During extended periods of 18 days in deionized water and artificial seawater, the electrode demonstrated negligible potential drifts of 0.36 and 0.14 mV/d, respectively. Notably, the electrode could maintain a stable potential even after being stored in a preservative solution for 67 days. Furthermore, the electrode showed a stable response to withstand pressures of up to 100 MPa, covering the vast majority of the seafloor. This innovative reference electrode is capable of maintaining a stable reference potential across various salinities, ionic strength, and full ocean depth, making it versatile for use in diverse aquatic environments, underscoring its significant potential for advancing oceanographic research and enabling new insights into the unexplored depths of oceans.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"24 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142841718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling van Hove Singularity-Boosted Photothermoelectric Response for Wearable Human-Radiation Detection","authors":"Mingyu Zhang, Zhanqi Zhang, Yiyong Shang, Nannan Shi, Zhijun Li, Jun Mao, Qian Zhang","doi":"10.1021/acssensors.4c02224","DOIUrl":"https://doi.org/10.1021/acssensors.4c02224","url":null,"abstract":"Van Hove singularity (vHs), the singularity point of density of states (DOS) in crystalline solids, is a research hotspot in emerging phenomena such as light–matter interaction, superconducting, and quantum anomalous Hall effect. Although the significance of vHs in photothermoelectric (PTE) effect has been recognized, its integral role in electron excitation and thermoelectric effect is still unclear, particularly in the mid-infrared band that suffers from Pauli blockade in semimetals. Here, we unveil the Fermi-level-modulated PTE behavior in the vicinity of vHs in carbon nanotubes, employing ionic-liquid gating. The concurrent enhancement of optical absorption and thermoelectric effect effectively improves the overall photoresponse by tens of folds at the vHs point. Generally applicable to strongly correlated systems such as metallic 1D nanomaterials and 2D Moiré systems, a quantitative correlation between PTE photodetectivity and electronic DOS is derived in the vicinity of the vHs point. Finally, chemically doped PTE mid-infrared detectors with graded doping levels are demonstrated to exhibit human-radiation sensitivity, high flexibility, and high transparency, paving the way for wearable sensor networks in healthcare systems and the Internet of Things.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"11 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142833069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of a Convenient and Highly Sensitive Sensor for the Detection of Myo in Serum Based on ELI-SERS","authors":"Jia-Min Zhai, Shanshan Xu, Xiao-Hang Wu, Shi-Ying Fu, Pei Liang, Zhen-Qun Guan, Yue-Jiao Zhang, Jian-Feng Li","doi":"10.1021/acssensors.4c02695","DOIUrl":"https://doi.org/10.1021/acssensors.4c02695","url":null,"abstract":"Acute myocardial infarction (AMI) is one of the most common causes of sudden death in cardiovascular disease, and myoglobin (Myo) is the first protein to be released in the blood after the attack, which is an important biomarker for clinical detection of AMI. The “Golden Rescue Time” for acute myocardial infarction is to intervene within the first 30 min after the attack; therefore, a rapid and accurate Myo detection method is needed urgently. In this study, we designed a combined enzyme-linked immunosorbent assay (ELISA) technique with surface-enhanced Raman scattering (SERS) immunoassay (ELI-SERS), which integrates the small sample volume, ease of operation, and excellent linearity of ELISA while utilizing the SERS technique and selecting the molecule with the Raman signal (IR-808), which is in resonance with the excitation wavelength, for further signal enhancement. The sensitivity of the system was further improved by optimizing the key factors in the assay such as incubation time, particle concentration, and temperature. Compared with the sandwich-structured magnetic bead method, no collection and concentration steps are required, simplifying the operation and ultimately realizing a sensitivity of a 5.3 pg/mL antigen detectable in 6 min. In actual serum samples, we achieve 100% accuracy and sensitivity by adding blockers to exclude the effect of heterophilic antibodies in serum and to reduce false positives in blank samples. We also validated the hepatitis B surface antigen test, demonstrating the universality of our system. Overall, this study designed an ultrasensitive and convenient SERS sensor for the detection of Myo, which extends the practical application of SERS and also contributes methods for the detection of other biomarkers.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"247 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142833070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One Receptor Show: Evaluation of Feature Extraction Methods for a Single Gas Sensor Based on α-Tocopherol-Substituted Zinc Phthalocyanine","authors":"Sabrine Dridi, Khaoula Khezami, Mahmut Durmuş, Mhemmed Gandour, Jamel Eddine Khiari, Gabriele Magna, Manuela Stefanelli, Corrado Di Natale, Roberto Paolesse","doi":"10.1021/acssensors.4c01909","DOIUrl":"https://doi.org/10.1021/acssensors.4c01909","url":null,"abstract":"A consistent part of gas sensor research activities aims to improve sensing performances by synthesizing new sensing materials, improving the selection of elements in arrays, and optimizing the feature extraction and classification algorithms. This paper combines most of these aspects to confer selectivity to a low-selectivity sensor by using feature extraction algorithms applied to the sensor response kinetics. Several algorithms were employed to represent the kinetic behavior of the sensor response during the adsorption and desorption phases. In detail, we utilized fitting functions, dynamic descriptors, and a mirrored fast Fourier transform (FFT) to extrapolate information from the desorption and adsorption phases. As sensitive material, we synthesized as a receptor a novel Zn(II) phthalocyanine derivative bearing long aliphatic chains, namely, 4-[2,5,7,8-tetramethyl-2-(4,8,12-trimethyl-tridecyl)-chroman-6-yloxy] units that allow good solubilization of the complex in most of the solvents tested and confer a large set of sites to potentially interact with volatile compound (VC) analytes by different portions of the molecular skeleton. After deposition onto a quartz crystal microbalance (QMB) transducer, this single sensor has been tested to recognize five VCs as chemical probes of different chemical families. Remarkably, the results disclose that responses at equilibrium are mainly correlated with nonspecific interactions, while the kinetic parameters are more correlated with stronger and more specific interactions. Finally, the desorption phases bear a higher information content about the chemical identities of the compounds. Eventually, features extracted by a modified version of the FFT obtained the highest clustering (principal component analysis) and classification performances (95% classification accuracy with linear discriminant analysis), suggesting the possibility of developing virtual electronic noses based on a single sensor and a minimal set of descriptors.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"20 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142833068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review on Long COVID Screening: Challenges and Perspectives Focusing on Exhaled Breath Gas Sensing","authors":"Lorena Díaz de León-Martínez, Gabriela Flores-Rangel, Luz E. Alcántara-Quintana, Boris Mizaikoff","doi":"10.1021/acssensors.4c02280","DOIUrl":"https://doi.org/10.1021/acssensors.4c02280","url":null,"abstract":"Long COVID (LC) is a great global health concern, affecting individuals recovering from SARS-CoV-2 infection. The persistent and varied symptoms across multiple organs complicate diagnosis and management, and an incomplete understanding of the condition hinders advancements in therapeutics. Current diagnostic methods face challenges related to standardization and completeness. To overcome this, new technologies such as sensor-based electronic noses are being explored for LC assessment, offering a noninvasive screening approach via volatile organic compounds (VOC) sensing in exhaled breath. Although specific LC-associated VOCs have not been fully characterized, insights from COVID-19 research suggest their potential as biomarkers. Additionally, AI-driven chemometrics are promising in identifying and predicting outcomes; despite challenges, AI-driven technologies hold the potential to enhance LC evaluation, providing rapid and accurate diagnostics for improved patient care and outcomes. This review underscores the importance of emerging and sensing technologies and comprehensive diagnostic strategies to address screening and treatment challenges in the face of LC.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"13 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142833074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bi2Sn2O7 Overlayer Assists Bilayer Chemiresistor in Humidity-Independent and Highly Selective Detection of Expiratory Acetone","authors":"Tianshuang Wang, Wei Tao, Xueying Kou, Liupeng Zhao, Peng Sun, Geyu Lu","doi":"10.1021/acssensors.4c02378","DOIUrl":"https://doi.org/10.1021/acssensors.4c02378","url":null,"abstract":"Constructing a bilayer structure has not been reported as a method to mitigate the adverse effect of water poisoning on oxide chemiresistors while simultaneously enhancing gas selectivity and sensitivity. To address this challenge, pyrochlore-Bi₂Sn₂O₇ has been first utilized as an overlayer on a ZnO sensing layer for constructing a bilayer acetone chemiresistor, leading to remarkable improvement in the performance for trace-level (500 p-p-b) acetone detection under high humidity (80% relative humidity). In addition, owing to the catalytic predecompositions of ethanol across the overlayer, an outstanding acetone gas selectivity (<i>S</i>_acetone/<i>S</i>_ethanol = 2.9) has been achieved, with a more than 4-fold improvement compared with monolayer ZnO chemiresistor (<i>S</i>_acetone/<i>S</i>_ethanol = 0.7). More significantly, comprehensive experiments coupled with in situ characterizations have verified the generation of hydroxyl radicals (•OH) on the Bi₂Sn₂O₇ overlayer. These radicals are capable of enhancing the kinetics between •OH and acetone, reducing the activation energy required for the gas sensing reaction, and thus leading to an unexpected phenomenon of enhanced acetone sensitivity under high humid conditions (<i>S</i>_{acetone at 80% RH} &gt; <i>S</i>_{acetone at 5% RH}). These demonstrations offer crucial insight into the precise design of highly efficient overlayers for breath sensing.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"87 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142833035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smart Packaging with Disposable NFC-enabled Wireless Gas Sensors for Monitoring Food Spoilage","authors":"Atharv Naik, Hong Seok Lee, Jack Herrington, Giandrin Barandun, Genevieve Flock, Firat Güder, Laura Gonzalez-Macia","doi":"10.1021/acssensors.4c02510","DOIUrl":"https://doi.org/10.1021/acssensors.4c02510","url":null,"abstract":"Gas sensors present an alternative to traditional off-package food quality assessment, due to their high sensitivity and fast response without the need of sample pretreatment. The safe integration of gas sensors into packaging without compromising sensitivity, response rate, and stability, however, remains a challenge. Such packaging integration of spoilage sensors is crucial for preventing food waste and transitioning toward more sustainable supply chains. Here, we demonstrate a wide-ranging solution to enable the use of gas sensors for the continuous monitoring of food spoilage, building upon our previous work on paper-based electrical gas sensors (PEGS). By comparing various materials commonly used in the food industry, we analyze the optimal membrane to encapsulate PEGS for packaging integration. Focusing on spinach as a high-value crop, we assess the feasibility of PEGS to monitor the gases released during its spoilage at low and room temperatures. Finally, we integrated the sensors with wireless communication and batteryless electronics, creating a user-friendly system to evaluate the spoilage of spinach, operated by a smartphone via near-field communication (NFC). The work reported here provides an alternative approach that surpasses traditional on-site and in-line monitoring, ensuring comprehensive monitoring of food shelf life.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"60 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142833071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MXene Nanoconfinement of SAM-Modified Molecularly Imprinted Electrochemical Biosensor for Point-of-Care Monitoring of Carcinoembryonic Antigen","authors":"Mina Hadian, Mohsen Rabbani, Laleh Shariati, Fahimeh Ghasemi, John F. Presley, Alireza Sanati","doi":"10.1021/acssensors.4c02420","DOIUrl":"https://doi.org/10.1021/acssensors.4c02420","url":null,"abstract":"The high rate of cancer worldwide and the heavy costs imposed on governments and humanity have always motivated researchers to develop point-of-care (POC) biosensors for easy diagnosis and monitoring of cancer treatment. Herein, we report on a label-free impedimetric biosensor based on Ti₃C₂T_<i>x</i> MXene and imprinted ortho-phenylenediamine (o-PD) for the detection of carcinoembryonic antigen (CEA), a biomarker for various cancers surveillance, especially colorectal cancer (CRC). Accordingly, MXene was drop-casted on the surface of a disposable silver electrode to increase the sensitivity and create high-energy nanoareas on the surface, which are usable for protein immobilization and detection. A self-assembled monolayer (SAM) was exploited for oriented CEA immobilization on the MXene-modified electrode. The monomer-protein interaction and successful protein removal were confirmed by molecular docking and atomic force microscopy (AFM) investigations to evaluate the quality of the fabricated molecularly imprinted polymer (MIP). Also, the role of MXene in increasing the electrical field inside the nanoareas was simulated using COMSOL Multiphysics software. A suitable limit of detection (9.41 ng/mL), an appropriate linear range of detection (10 to 100 ng/mL) in human serum, and a short detection time (10 min) resulted from the use of SAM/MIP next to MXene. This biosensor presented outstanding repeatability (97.60%) and reproducibility (98.61%). Moreover, acceptable accuracy (between 93.04 and 116.04%) in clinical serum samples was obtained compared with immunoassay results, indicating the high potential of our biosensor for real sample analysis. This biomimetic and disposable sensor provides a cost-effective method for facile and POC monitoring of cancer patients during treatment.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"9 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142816220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kirigami Design Smart Contact Lens for Highly Sensitive Eyelid Pressure Measurement","authors":"Wen Chen, Songhao Chen, Xiaoyu Zhao, Lan Yang, Yunbiao Zhao, Ruihua Wei, Jinfang Wu","doi":"10.1021/acssensors.4c02361","DOIUrl":"https://doi.org/10.1021/acssensors.4c02361","url":null,"abstract":"Eyelid pressure is a crucial biomechanical parameter for ocular health and refractive status, yet measuring it poses challenges related to flexibility, sensitivity, and regional specificity. This study introduces a novel smart contact lens that incorporates kirigami designs and an iontronic capacitive sensing array to enhance flexibility and conformability. The unique structural composition of this device allows for precise and simultaneous monitoring of eyelid pressure in multiple regions with a high sensitivity and seamlessly fit across corneal curvatures. The efficacy of the sensor has been thoroughly confirmed through comprehensive evaluations in rabbits and porcine eyes, demonstrating improved conformity and sensitivity compared to conventional single-point sensors. Assessments have been conducted in various conditions, including under anesthesia and in awake states, as well as the deliberate alteration of intraocular pressure fluctuations, all affirming the exceptional accuracy in detecting eyelid pressure. We envision that the smart contact lens has the potential to revolutionize diagnosis and management of eyelid-related ocular diseases.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"41 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142816221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanopaper Integrated Smart Device: An Opto-Electrochemical Biosensor for Real-Time Dual On-Field Detection of Organophosphorus Pesticides","authors":"Amir Reza Sharifi, Vincenzo Mazzaracchio, Leonardo Duranti, Ludovica Gullo, Simone Brannetti, Mohammad Peyravian, Mohammad Ali Kiani, Fabiana Arduini","doi":"10.1021/acssensors.4c02000","DOIUrl":"https://doi.org/10.1021/acssensors.4c02000","url":null,"abstract":"The frequent and excessive use of organophosphorus pesticides in the agriculture industry raises persistent concerns regarding their environmental protection and public health implications. Addressing these issues requires the development of affordable and reliable sensing platforms for on-field monitoring to mitigate their adverse impacts promptly. This study utilizes nanocellulose papers (bacterial and TEMPO-oxidized) combined with butyrylcholinesterase to create a novel reagent-free and orthogonal nanobioplatform featuring smart opto-electrochemical dual outputs. An integrated nano-PAD, preloaded with enzymes and enzymatic substrates, is fabricated using wax-printing and screen-printing technologies. The nano-PAD measures opto-electroactive products, specifically indoxyl and thiocholine, whose concentrations correlate directly with the enzymatic inhibition caused by paraoxon, used as the organophosphate model. To enhance user convenience and meet the requirements for smart real-time point-of-need detection, integration of the nano-PAD with a smartphone-operated miniaturized potentiostat and a self-developed portable smart optical reader is achieved. The developed bioanalytical platform, further supported by a self-developed Android application, enables accurate and efficient quantification of dual signals in real time. The system covers a wide detection range of paraoxon (20–100 ppb) and demonstrates reliable recovery levels (ranging from 98 to 107%) in a real matrix, specifically wastewater. Given these demonstrated capabilities, this innovative biosensing strategy holds substantial potential for practical application in environmental surveillance, facilitating timely and informed environmental management decisions, particularly in resource-limited settings where traditional analytical tools are inaccessible.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"1 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142809403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}