ACS Sensors最新文献_第2页

PtNPs/Prussian Blue-Modified Microelectrode Arrays for Detection of Key Neurons Regulating Hibernation State. PtNPs/普鲁士蓝修饰微电极阵列检测调节休眠状态的关键神经元。

IF 8.9 1区化学

ACS Sensors Pub Date : 2025-07-28 DOI: 10.1021/acssensors.5c00310

Yiding Wang,Chao Yang,Yilin Song,Guihua Xiao,Jiangbei Cao,Weidong Mi,Gucheng Yang,Wei Xu,Yuchuan Dai,Juntao Liu,Zhongquan Dai,Lina Qu,Jinping Luo,Yinghui Li,Xinxia Cai

{"title":"PtNPs/Prussian Blue-Modified Microelectrode Arrays for Detection of Key Neurons Regulating Hibernation State.","authors":"Yiding Wang,Chao Yang,Yilin Song,Guihua Xiao,Jiangbei Cao,Weidong Mi,Gucheng Yang,Wei Xu,Yuchuan Dai,Juntao Liu,Zhongquan Dai,Lina Qu,Jinping Luo,Yinghui Li,Xinxia Cai","doi":"10.1021/acssensors.5c00310","DOIUrl":"https://doi.org/10.1021/acssensors.5c00310","url":null,"abstract":"Studying neuronal activity during hibernation's extremely low metabolic state may offer novel solutions for metabolic disorders, stroke treatment, and space travel challenges. To explore hibernation's neural mechanisms, we developed a natural hibernation model using Siberian chipmunks(Tamias sibiricus). However, their characteristic weak neuronal discharge and prolonged hibernation periods necessitate electrodes with both enhanced detection sensitivity and exceptional long-term stability. We developed a new nanocomposite platinum nanoparticles/Prussian blue-modified microelectrode arrays (MEAs) aimed at solving the above difficulties. Prussian blue can react with reactive oxygen species to reduce inflammation during the detection process; therefore, MEAs achieved a high signal-to-noise ratio (15.53 ± 6.73) in the detection of individual neurons, even against weak neural activity in dormant states. We discovered that three types of neurons exhibited distinct responses to hibernation and established three-dimensional characteristics to differentiate them through algorithmic processing of the signal. Type 3 neurons discharged in the extremely low metabolic state, indicating that Type 3 neurons are critical for chipmunks to enter and maintain deep hibernation without damaging the brain. The theta frequency band of local field potentials (LFPs) rapidly increased during arousal, representing consciousness arousal, and can be used as a key signal to predict arousal. These results fill part of the research gaps in the characteristics of critical neurons during hibernation and provide a solid foundation for regulating neurons to control the body into a state of low temperature and low metabolism.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"37 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sensitive Detection of Vitamin B2 in a Microdroplet with a Living Graphene Hydrogel Needle. 用活石墨烯水凝胶针灵敏检测微滴中的维生素B2。

IF 8.9 1区化学

ACS Sensors Pub Date : 2025-07-28 DOI: 10.1021/acssensors.5c00042

Jin-Feng Lu,Jie Wang,Heng-Chi Liu,Xing-Ming Zhao,Hareef Ahmed Keerio,Hong-Cheng Wang,Yang-Chun Yong

{"title":"Sensitive Detection of Vitamin B2 in a Microdroplet with a Living Graphene Hydrogel Needle.","authors":"Jin-Feng Lu,Jie Wang,Heng-Chi Liu,Xing-Ming Zhao,Hareef Ahmed Keerio,Hong-Cheng Wang,Yang-Chun Yong","doi":"10.1021/acssensors.5c00042","DOIUrl":"https://doi.org/10.1021/acssensors.5c00042","url":null,"abstract":"As a water-soluble vitamin, Vitamin B2 (VB2) is crucial for the health of living organisms. Therefore, developing sensitive and selective methods for detecting VB2 is essential for the quality control of food and pharmaceuticals as well as for clinical diagnosis. In this study, a cell-embedded living graphene hydrogel needle was prepared under ambient atmospheric conditions, where the electroactive bacteria Shewanella oneidensis MR-1 was used to induce the reduction of graphene oxide (GO) to graphene hydrogel under the confinement effect with a glass capillary tube. By using this living graphene hydrogel needle, an electrochemical biosensor for the detection of VB2 in microdroplet samples was developed. By taking advantage of a microscale graphene needle and electroactive S. oneidensis MR-1, this biosensor exhibited high sensitivity (LOD = 8.42 nM), excellent selectivity, and good anti-interference ability for amperometric detection of VB2 in a microdroplet (1 μL, the record-low sample volume). This work provided a reliable tool for trace detection of VB2 with minimized sample requirement, offering a sensitive and practical approach for food safety inspection and disease diagnosis with precious or limited samples.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"5 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Active Microfluidic Platforms for Particle Separation and Integrated Sensing Applications. 颗粒分离和集成传感应用的主动微流控平台。

IF 8.9 1区化学

ACS Sensors Pub Date : 2025-07-28 DOI: 10.1021/acssensors.5c01896

Tianlong Zhang,Tianyuan Zhou,Qi Cui,Xiaoming Feng,Shilun Feng,Ming Li,Yang Yang,Yoichiroh Hosokawa,Guizhong Tian,Amy Q Shen,Yaxiaer Yalikun

{"title":"Active Microfluidic Platforms for Particle Separation and Integrated Sensing Applications.","authors":"Tianlong Zhang,Tianyuan Zhou,Qi Cui,Xiaoming Feng,Shilun Feng,Ming Li,Yang Yang,Yoichiroh Hosokawa,Guizhong Tian,Amy Q Shen,Yaxiaer Yalikun","doi":"10.1021/acssensors.5c01896","DOIUrl":"https://doi.org/10.1021/acssensors.5c01896","url":null,"abstract":"The active manipulation and separation of particles in microfluidic systems using externally applied forces, such as acoustic, electric, magnetic, and optical fields, have transformed our capacity to detect pathogens, biomarkers, and environmental analytes with high precision and adaptability. These active microfluidic approaches offer enhanced control over particle trajectories, tunable separation thresholds, and compatibility with diverse sample types, making them highly promising for integration with downstream sensing platforms. This Perspective outlines recent advances in active microfluidic separation strategies and explores their synergies with biochemical assays, such as lateral flow tests, electrochemical sensors, and next-generation sequencing. We highlight the unique advantages and limitations of each technique and provide a comparative analysis across performance metrics such as throughput, specificity, and scalability. We also identify key challenges, such as system integration, throughput constraints, and label dependency, and propose future research directions to accelerate the deployment of these technologies in clinical, environmental, and point-of-care settings.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"24 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144720365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

On-Chip Integration of Self-Joule-Heated Oxide Nanosensors Discriminates Odor Components via Efficient Data Acquisition. 片上集成自焦耳加热氧化物纳米传感器鉴别气味成分通过有效的数据采集。

IF 8.9 1区化学

ACS Sensors Pub Date : 2025-07-28 DOI: 10.1021/acssensors.5c00641

Shintaro Nagata,Tsunaki Takahashi,Haruka Honda,Ryuichiro Nakagori,Yohsuke Shiiki,Jiangyang Liu,Wataru Tanaka,Takuro Hosomi,Hiroki Ishikuro,Takeshi Yanagida

{"title":"On-Chip Integration of Self-Joule-Heated Oxide Nanosensors Discriminates Odor Components via Efficient Data Acquisition.","authors":"Shintaro Nagata,Tsunaki Takahashi,Haruka Honda,Ryuichiro Nakagori,Yohsuke Shiiki,Jiangyang Liu,Wataru Tanaka,Takuro Hosomi,Hiroki Ishikuro,Takeshi Yanagida","doi":"10.1021/acssensors.5c00641","DOIUrl":"https://doi.org/10.1021/acssensors.5c00641","url":null,"abstract":"Current data-based informatics approaches require efficient acquisition and processing of large data. Additionally, the collection and analysis of chemical information, involving combinations of molecules, require highly integrated sensors working in parallel. However, a trade-off exists between the collection of large data for high accuracy and minimizing the energy required to operate large arrays of sensors to detect the broadest range of analytes possible. The difficulty in achieving the high-density integration of heterogeneous sensing materials, which is inevitable in conventional chemical sensor arrays, is a critical bottleneck for efficient chemical data acquisition. Here we demonstrate the on-chip integration of self-Joule-heated oxide nanochannel sensors for discriminating complex odor components. Local temperature control of metal oxide surfaces via self-Joule-heating in nanofilm channels enables the individual modulation of chemical reactivity within each sensor of the integrated homogeneous-material sensor array chip. Herein, micrometer-scale temperature control and the modulation of molecular sensing properties were successfully implemented by optimizing the electrothermal design of SnO2 nanofilm channel sensors. The fabricated sensor arrays can identify and classify complex odors from bananas and essential oils. Regression estimation of the ripeness (sugar-to-acid ratio) of bananas and the classification of four essential oils were demonstrated via simultaneous multitemperature operations of the homogeneous SnO2 nanofilm channel sensor array. Feature analysis of the regression and classification models revealed the significant contribution of the sensor recovery time to the accuracy of data discrimination, highlighting that the desorption process modulation of molecules on the metal oxide surface via Joule heating plays a key role in complex odor discrimination.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"144 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coreaction Accelerator Au Nanoparticle-Confined Coordination Polymers with Highly Efficient Electrochemiluminescence for Sensitive Detection of Neurological Disease Biomarkers. 协同反应促进剂金纳米粒子-具有高效电化学发光的限制性配位聚合物用于神经系统疾病生物标志物的敏感检测。

IF 8.9 1区化学

ACS Sensors Pub Date : 2025-07-28 DOI: 10.1021/acssensors.5c01053

Li Song,Yilan Ding,Shuchun Bu,Yuqin Yang,Yaqin Chai,Yingzi Fu,Pu Zhang,Ruo Yuan

{"title":"Coreaction Accelerator Au Nanoparticle-Confined Coordination Polymers with Highly Efficient Electrochemiluminescence for Sensitive Detection of Neurological Disease Biomarkers.","authors":"Li Song,Yilan Ding,Shuchun Bu,Yuqin Yang,Yaqin Chai,Yingzi Fu,Pu Zhang,Ruo Yuan","doi":"10.1021/acssensors.5c01053","DOIUrl":"https://doi.org/10.1021/acssensors.5c01053","url":null,"abstract":"In this study, a highly efficient electrochemiluminescent (ECL) coordination polymer, Au-Zn-DTBA, was synthesized by employing 2,2'-dithiodibenzoic acid (DTBA) as the luminescent ligand and Zn2+ as the metal node as well as Au nanoparticles (AuNPs) as coreaction accelerators confined to DTBA via Au-S bonds for the construction of biosensors for sensitive detection of the biomarker of neurological disease, dopamine. Compared to the Zn-DTBA ECL system without a coreaction accelerator, Au-Zn-DTBA exhibits a 4-fold enhancement in ECL intensity, since AuNPs confined in Zn-DTBA could promote the coreactant K2S2O8 to produce abundant sulfate radicals SO4•- for significantly enhancing the ECL efficiency of Zn-DTBA. As a result, an ultrasensitive ECL biosensor employing the Au-Zn-DTBA/K2S2O8 ECL system was developed for dopamine detection, achieving a low detection limit of 0.41 nM and outperforming most previously reported dopamine biosensors. This strategy demonstrates the significant potential of coreaction accelerators based on the confining effect, offering a novel approach for increasing ECL efficiency and expanding its application in clinical analysis.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"284 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Minimally Invasive and in Situ Capacitive Sensing of Cardiac Troponin I from Interstitial Fluid. 心肌间质液肌钙蛋白I的微创原位电容传感。

IF 9.1 1区化学

ACS Sensors Pub Date : 2025-07-27 DOI: 10.1021/acssensors.5c01691

Hadi Mirzajani, Parviz Zolfaghari, Beril Yagmur Koca, Hakan Urey

{"title":"Minimally Invasive and in Situ Capacitive Sensing of Cardiac Troponin I from Interstitial Fluid.","authors":"Hadi Mirzajani, Parviz Zolfaghari, Beril Yagmur Koca, Hakan Urey","doi":"10.1021/acssensors.5c01691","DOIUrl":"https://doi.org/10.1021/acssensors.5c01691","url":null,"abstract":"<p><p>Current diagnostic approaches for myocardial infarction (MI) rely on blood-based cardiac biomarker analysis by centralized instruments, often delaying timely clinical decisions. We present a microneedle-based capacitive biosensor (MiCaP) for in situ minimally invasive monitoring of cardiac troponin I (cTnI) in interstitial fluid (ISF) for point-of-care (POC) applications. MiCaP is a label-free biosensor operating based on nonfaradaic sensing by monitoring electric double layer capacitance at the microneedle-ISF interface. We extracted a simplified equivalent circuit model for MiCaP inserted into the skin, confirming that the measured capacitance variations originate from cTnI binding to surface-immobilized antibodies. MiCaP was fabricated by using a scalable process and functionalized with anti-cTnI antibodies. In vitro measurements showed a dynamic detection range of 10 pg/mL to 10 ng/mL, a limit of detection (LOD) of 3.27 pg/mL, and a total assay response time of less than 15 min. A spike-and-recovery test using cTnI-spiked human serum yielded a recovery accuracy exceeding 93%. In vivo studies in rats demonstrated ISF cTnI levels of 3 ± 0.4 pg/mL in controls and 912 ± 683 pg/mL in experimental animals, indicating an increasing trend consistent with serum concentrations measured using a clinical immunoassay. These results support the potential of MiCaP as a minimally invasive biosensing platform for cardiac biomarker monitoring, with possible extension to multiplexed ISF-based diagnostics in the POC.</p>","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":" ","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144725903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 8.2 1区化学

ACS Sensors Pub Date : 2025-07-25

Ge Wang, Haijie Cai, Jinlei Wei, Xingyu Wang, Xueqing Zhang, Tianjun Ni* and Yongheng Zhu*,