Current Progress of 5-Methylcytosine RNA Methylation in Non-Neoplastic Kidney Diseases.

Q4 Medicine
Zhang Chen, Zhao Zi-Xia, W U Si, Luan Jun-Jun, Zhou Hua
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引用次数: 0

Abstract

RNA methylation is a key process in the epigenetic regulation of post-transcriptional gene expression.5-Methylcytosine(m5C)is a type of RNA methylation,commonly existing in eukaryotic mRNA and non-coding RNAs.It mainly regulates transfer RNA stability,ribosomal RNA assembly,and mRNA translation,stability,and translation.RNA methylation is dynamically reversible and regulated by methyltransferase,demethylase,and methylation recognition protein.It has been confirmed that aberrant m5C RNA methylation is involved in the pathogenesis of non-neoplastic kidney diseases.This article summarizes the current progress of m5C RNA methylation associated with non-neoplastic acute and chronic kidney diseases,aiming to provide potential targets for the diagnosis and treatment of such diseases.

5-甲基胞嘧啶RNA甲基化在非肿瘤性肾病中的研究进展
RNA甲基化是表观遗传调控转录后基因表达的关键过程,5-甲基胞嘧啶(5- methylcytosine, m5C)是一种RNA甲基化,普遍存在于真核mRNA和非编码RNA中。它主要调控转运RNA的稳定性、核糖体RNA的组装以及mRNA的翻译、稳定和翻译。RNA甲基化是动态可逆的,受甲基转移酶、去甲基化酶和甲基化识别蛋白的调控。已证实异常m5C RNA甲基化参与非肿瘤性肾脏疾病的发病机制。本文综述了m5C RNA甲基化与非肿瘤性急慢性肾脏疾病相关的研究进展,旨在为此类疾病的诊断和治疗提供潜在靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
中国医学科学院学报
中国医学科学院学报 Medicine-Medicine (all)
CiteScore
0.60
自引率
0.00%
发文量
6813
期刊介绍: Acta Academiae Medicinae Sinicae was founded in February 1979. It is a comprehensive medical academic journal published in China and abroad, supervised by the Ministry of Health of the People's Republic of China and sponsored by the Chinese Academy of Medical Sciences and Peking Union Medical College. The journal mainly reports the latest research results, work progress and dynamics in the fields of basic medicine, clinical medicine, pharmacy, preventive medicine, biomedicine, medical teaching and research, aiming to promote the exchange of medical information and improve the academic level of medicine. At present, the journal has been included in 10 famous foreign retrieval systems and their databases [Medline (PubMed online version), Elsevier, EMBASE, CA, WPRIM, ExtraMED, IC, JST, UPD and EBSCO-ASP]; and has been included in important domestic retrieval systems and databases [China Science Citation Database (Documentation and Information Center of the Chinese Academy of Sciences), China Core Journals Overview (Peking University Library), China Science and Technology Paper Statistical Source Database (China Science and Technology Core Journals) (China Institute of Scientific and Technological Information), China Science and Technology Journal Paper and Citation Database (China Institute of Scientific and Technological Information)].
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