MicroRNA-1976在异常细胞周期疾病中的研究进展。

Q4 Medicine

中国医学科学院学报 Pub Date : 2025-08-01 DOI:10.3881/j.issn.1000-503X.16376

Hao-Yu Ji, Hao Chen, Liang Shi, Meng Zhang, Ting Chen, Ying-Ming Kong, Rong-Ke Feng

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引用次数: 0

摘要

大多数肿瘤细胞和健康神经元在G0期处于静止状态。一旦在一定条件下异常地重新进入细胞周期，肿瘤细胞的增殖和神经元的退行性坏死就会开始。从细胞周期的角度来看，癌症和中枢神经系统疾病这两种看似不同的疾病类型，却有着共同的发病机制。这类疾病被称为细胞周期异常疾病。miR-1976作为一种新发现的microRNA(miR)，与细胞周期的调控密切相关。本文就miR-1976在癌症和中枢神经系统疾病中的研究进展进行综述，旨在为miR-1976在未来异常细胞周期疾病中的临床应用提供参考。

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Advances in the Studies of MicroRNA-1976 in Aberrant Cell Cycle Diseases.

Most tumor cells and healthy neurons are at rest during G0 phase.Once the cell cycle is abnormally re-entered under certain conditions,the proliferation of tumor cells and the degenerative necrosis of neurons can be initiated.From the perspective of the cell cycle,cancer and central nervous system diseases,two seemingly different disease types,have a common pathogenesis.This type of diseases is named aberrant cell cycle diseases.As a newly discovered microRNA(miR),miR-1976 is closely related to the regulation of the cell cycle.This review summarizes the progress in the research on miR-1976 in cancer and central nervous system diseases,aiming to provide a reference for the clinical application of miR-1976 in aberrant cell cycle diseases in the future.

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来源期刊

中国医学科学院学报 Medicine-Medicine (all)

CiteScore

0.60

自引率

0.00%

发文量

6813

期刊介绍： Acta Academiae Medicinae Sinicae was founded in February 1979. It is a comprehensive medical academic journal published in China and abroad, supervised by the Ministry of Health of the People's Republic of China and sponsored by the Chinese Academy of Medical Sciences and Peking Union Medical College. The journal mainly reports the latest research results, work progress and dynamics in the fields of basic medicine, clinical medicine, pharmacy, preventive medicine, biomedicine, medical teaching and research, aiming to promote the exchange of medical information and improve the academic level of medicine. At present, the journal has been included in 10 famous foreign retrieval systems and their databases [Medline (PubMed online version), Elsevier, EMBASE, CA, WPRIM, ExtraMED, IC, JST, UPD and EBSCO-ASP]; and has been included in important domestic retrieval systems and databases [China Science Citation Database (Documentation and Information Center of the Chinese Academy of Sciences), China Core Journals Overview (Peking University Library), China Science and Technology Paper Statistical Source Database (China Science and Technology Core Journals) (China Institute of Scientific and Technological Information), China Science and Technology Journal Paper and Citation Database (China Institute of Scientific and Technological Information)].