{"title":"仿生天然纤维衍生的电子皮肤，配备智能药物释放系统，用于先进的强大集成黑色素瘤治疗","authors":"Xinhua Liu, Yifan Fei, Boqiang Cui, Xing Chen, Jiamin Zhang, Ouyang Yue, Zhongxue Bai, Ling Wen, Huie Jiang","doi":"10.1186/s42825-025-00210-z","DOIUrl":null,"url":null,"abstract":"<div><p>Malignant melanoma, a highly aggressive malignancy, necessitates innovative therapeutic strategies integrating biomaterial innovation with multimodal treatment modalities. Herein, we report the development of a collagen-derived bioelectronic skin (c-ADM) nanoengineered via interfacial assembly of porcine acellular dermal matrix (ADM)—a natural collagen-rich scaffold—with conductive poly (3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) and copper sulfide nanoparticles (CuS-NPs). This hybrid system synergizes photothermal ablation, stimuli-responsive drug delivery, and electrostimulation (ES) for comprehensive postoperative melanoma management and tissue regeneration. The c-ADM platform exhibits superior mechanical robustness, enzymatic resistance, and biocompatibility, enabling real-time motion monitoring while maintaining structural integrity in dynamic physiological environments. Leveraging the photothermal efficiency of CuS-NPs, localized hyperthermia (ΔT > 40 °C) under near-infrared (NIR) irradiation induces irreversible melanoma cell apoptosis. Concurrently, laser-triggered temperature-responsive drug release enables synchronized photothermal-chemotherapy, with sustained doxorubicin release profiles at tumor sites. Notably, pH-responsive Cu<sup>2</sup>⁺ liberation from CuS-NPs facilitates intelligent functional switching: bactericidal activity at tumor microenvironment pH (5.0–6.0) and pro-regenerative effects under physiological pH (7.4) for wound healing. In vitro/in vivo assessments confirm c-ADM’s dual therapeutic efficacy including ES-enhanced cancer cell death via mitochondrial dysfunction and accelerated full-thickness skin regeneration through collagen remodeling and angiogenesis modulation. This work establishes a collagen-based bioelectronic scaffold for personalized oncological care, integrating intraoperative tumor eradication, postoperative surveillance, and adaptive tissue reconstruction.</p><h3>Graphic Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":640,"journal":{"name":"Journal of Leather Science and Engineering","volume":"7 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://JLSE.SpringerOpen.com/counter/pdf/10.1186/s42825-025-00210-z","citationCount":"0","resultStr":"{\"title\":\"Bio-inspired natural fibers-derived e-skin equipped with intelligent drug-release system for advanced robustly-integrated melanoma therapy\",\"authors\":\"Xinhua Liu, Yifan Fei, Boqiang Cui, Xing Chen, Jiamin Zhang, Ouyang Yue, Zhongxue Bai, Ling Wen, Huie Jiang\",\"doi\":\"10.1186/s42825-025-00210-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Malignant melanoma, a highly aggressive malignancy, necessitates innovative therapeutic strategies integrating biomaterial innovation with multimodal treatment modalities. Herein, we report the development of a collagen-derived bioelectronic skin (c-ADM) nanoengineered via interfacial assembly of porcine acellular dermal matrix (ADM)—a natural collagen-rich scaffold—with conductive poly (3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) and copper sulfide nanoparticles (CuS-NPs). This hybrid system synergizes photothermal ablation, stimuli-responsive drug delivery, and electrostimulation (ES) for comprehensive postoperative melanoma management and tissue regeneration. The c-ADM platform exhibits superior mechanical robustness, enzymatic resistance, and biocompatibility, enabling real-time motion monitoring while maintaining structural integrity in dynamic physiological environments. Leveraging the photothermal efficiency of CuS-NPs, localized hyperthermia (ΔT > 40 °C) under near-infrared (NIR) irradiation induces irreversible melanoma cell apoptosis. Concurrently, laser-triggered temperature-responsive drug release enables synchronized photothermal-chemotherapy, with sustained doxorubicin release profiles at tumor sites. Notably, pH-responsive Cu<sup>2</sup>⁺ liberation from CuS-NPs facilitates intelligent functional switching: bactericidal activity at tumor microenvironment pH (5.0–6.0) and pro-regenerative effects under physiological pH (7.4) for wound healing. In vitro/in vivo assessments confirm c-ADM’s dual therapeutic efficacy including ES-enhanced cancer cell death via mitochondrial dysfunction and accelerated full-thickness skin regeneration through collagen remodeling and angiogenesis modulation. This work establishes a collagen-based bioelectronic scaffold for personalized oncological care, integrating intraoperative tumor eradication, postoperative surveillance, and adaptive tissue reconstruction.</p><h3>Graphic Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":640,\"journal\":{\"name\":\"Journal of Leather Science and Engineering\",\"volume\":\"7 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-08-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://JLSE.SpringerOpen.com/counter/pdf/10.1186/s42825-025-00210-z\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Leather Science and Engineering\",\"FirstCategoryId\":\"1087\",\"ListUrlMain\":\"https://link.springer.com/article/10.1186/s42825-025-00210-z\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Leather Science and Engineering","FirstCategoryId":"1087","ListUrlMain":"https://link.springer.com/article/10.1186/s42825-025-00210-z","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Bio-inspired natural fibers-derived e-skin equipped with intelligent drug-release system for advanced robustly-integrated melanoma therapy
Malignant melanoma, a highly aggressive malignancy, necessitates innovative therapeutic strategies integrating biomaterial innovation with multimodal treatment modalities. Herein, we report the development of a collagen-derived bioelectronic skin (c-ADM) nanoengineered via interfacial assembly of porcine acellular dermal matrix (ADM)—a natural collagen-rich scaffold—with conductive poly (3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) and copper sulfide nanoparticles (CuS-NPs). This hybrid system synergizes photothermal ablation, stimuli-responsive drug delivery, and electrostimulation (ES) for comprehensive postoperative melanoma management and tissue regeneration. The c-ADM platform exhibits superior mechanical robustness, enzymatic resistance, and biocompatibility, enabling real-time motion monitoring while maintaining structural integrity in dynamic physiological environments. Leveraging the photothermal efficiency of CuS-NPs, localized hyperthermia (ΔT > 40 °C) under near-infrared (NIR) irradiation induces irreversible melanoma cell apoptosis. Concurrently, laser-triggered temperature-responsive drug release enables synchronized photothermal-chemotherapy, with sustained doxorubicin release profiles at tumor sites. Notably, pH-responsive Cu2⁺ liberation from CuS-NPs facilitates intelligent functional switching: bactericidal activity at tumor microenvironment pH (5.0–6.0) and pro-regenerative effects under physiological pH (7.4) for wound healing. In vitro/in vivo assessments confirm c-ADM’s dual therapeutic efficacy including ES-enhanced cancer cell death via mitochondrial dysfunction and accelerated full-thickness skin regeneration through collagen remodeling and angiogenesis modulation. This work establishes a collagen-based bioelectronic scaffold for personalized oncological care, integrating intraoperative tumor eradication, postoperative surveillance, and adaptive tissue reconstruction.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
