Journal of Leather Science and Engineering最新文献

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A simple method for identifying the elementary units governing the mechanical properties in leather materials
Journal of Leather Science and Engineering Pub Date : 2025-03-01 DOI: 10.1186/s42825-024-00184-4
Wenjun Long, Liangqiong Peng, Jiheng Li, Yue Yu, Wenhua Zhang
{"title":"A simple method for identifying the elementary units governing the mechanical properties in leather materials","authors":"Wenjun Long,&nbsp;Liangqiong Peng,&nbsp;Jiheng Li,&nbsp;Yue Yu,&nbsp;Wenhua Zhang","doi":"10.1186/s42825-024-00184-4","DOIUrl":"10.1186/s42825-024-00184-4","url":null,"abstract":"<div><p>Understanding the mechanical properties of leather is crucial for expanding its range of application, but the influence of collagen fibril bundles (FBs) remains unclear. In this study, 12 kinds of bovine leather were prepared with varying FB sizes using Cr(III), Zr(IV) and aldehyde as the crosslinking agents along with different fillers such as rapeseed oil phosphate, polyacrylic acid and their combination. The experimental results revealed that the tear strength of leather was affected by the crosslinking agents, which could be further adjusted by the filler. Accordingly, a simple method using mercury intrusion porosimetry has been proposed for determining the FB size based on the crack-bridging model. Specifically, the tear strength of leather showed a strong correlation with the FB radius where the strength increased with the decrease in FB radius. This indicated that FBs served as the elementary units contributing to loading strength. These findings may facilitate the development of cleaner technologies for fabricating high-performance leather through the regulation of FB size.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":640,"journal":{"name":"Journal of Leather Science and Engineering","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://JLSE.SpringerOpen.com/counter/pdf/10.1186/s42825-024-00184-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143521646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of a dual-function peptide for the detection and haematopoietic potency assessment of type I collagen hydrolysates
Journal of Leather Science and Engineering Pub Date : 2025-02-26 DOI: 10.1186/s42825-024-00188-0
Guiya Deng, Jiajun Wang, Cuicui Men, Keyi Cao, Chengming Li, Liang Zheng, Haibin Liu, Shangwei Guo, Yaqin Huang
{"title":"Identification of a dual-function peptide for the detection and haematopoietic potency assessment of type I collagen hydrolysates","authors":"Guiya Deng,&nbsp;Jiajun Wang,&nbsp;Cuicui Men,&nbsp;Keyi Cao,&nbsp;Chengming Li,&nbsp;Liang Zheng,&nbsp;Haibin Liu,&nbsp;Shangwei Guo,&nbsp;Yaqin Huang","doi":"10.1186/s42825-024-00188-0","DOIUrl":"10.1186/s42825-024-00188-0","url":null,"abstract":"<div><p>Type I collagen hydrolysate with haematopoietic activity has shown tremendous potential for application in the functional food fields. The identification of peptide with haematopoietic activity to ensure the efficiency of functional foods remains challenging because of the vast combinatorial potential of short peptides from collagen hydrolysates. In the present study, we identified a novel marker peptide (the I-1 peptide, GAAGLpGPK, p: hydroxyproline) for type I collagen with haematopoietic capabilities via theoretical sequence analysis and computational prediction of activity. The I-1 peptide was shown to increase the survival rate of haematopoietic stem cells following injury induced by 5-fluorouracil (5-FU), increasing the survival rate from 65.40 to 105.28%, thereby exhibiting significant haematopoietic activity. More importantly, the mechanism underlying the haematopoietic activity of the I-1 peptide was analogous to activate the JAK/STAT signalling pathway mediated by granulocyte‒macrophage colony‒stimulating factor. On this basis, a high-precision method for the detection of type I collagen hydrolysates was developed using the I-1 peptide (relative standard deviation = 1.57%). This study not only provides novel perspectives for the exploration of haematopoietic peptides but also offers a new methodology for controlling the bioactivity of collagen-based food products.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":640,"journal":{"name":"Journal of Leather Science and Engineering","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://JLSE.SpringerOpen.com/counter/pdf/10.1186/s42825-024-00188-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143489638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Topological data analysis with digital microscope leather images for animal species classification
Journal of Leather Science and Engineering Pub Date : 2025-02-14 DOI: 10.1186/s42825-024-00187-1
Takuya Ehiro, Takeshi Onji
{"title":"Topological data analysis with digital microscope leather images for animal species classification","authors":"Takuya Ehiro,&nbsp;Takeshi Onji","doi":"10.1186/s42825-024-00187-1","DOIUrl":"10.1186/s42825-024-00187-1","url":null,"abstract":"<div><p>This study presents a method for classifying cow and horse leather using a small number of digital microscope images and topological data analysis. In this method, hair pore coordinates in the images are used as essential information for classification. First, the coordinates were semiautomatically extracted using conventional image processing methods and persistent homology (PH) computation. Binary images with white pixels corresponding to the coordinates were generated, and their PHs were computed using filtration based on the Manhattan distance. In addition to the pairwise distance between the two pores, zeroth- and first-order lifetimes were used as explanatory variables to construct the classifier. Among the three explanatory variables, the zeroth-order lifetime resulted in the highest classification accuracy (86%) for the test data. Furthermore, we constructed logistic regression (LR) and random forest (RF) models using the zeroth-order lifetime computed from all images and conducted model interpretation. In both LR and RF, information on a zeroth-order lifetime of less than 10 was used as an important explanatory variable. Additionally, the inverse analysis of birth–death pairs suggested that the zeroth-order lifetime contains topological information distinct from the conventional pairwise distance. Our proposed method is designed to be robust in data-limited situations because it only uses hair pore coordinates as explanatory variables and does not require other information, such as hair pore density or pore size. This study demonstrates that accurate classifiers can be obtained using topological features related to hair pore arrangement.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":640,"journal":{"name":"Journal of Leather Science and Engineering","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://JLSE.SpringerOpen.com/counter/pdf/10.1186/s42825-024-00187-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143404136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Collagen peptide protects Saccharomyces cerevisiae from furfural stress for enhancing bioethanol synthesis
Journal of Leather Science and Engineering Pub Date : 2025-02-02 DOI: 10.1186/s42825-024-00183-5
Ming Yang, Xia Li, Bo Wang, Xian Liu, Bo Zhang, Xue-Pin Liao
{"title":"Collagen peptide protects Saccharomyces cerevisiae from furfural stress for enhancing bioethanol synthesis","authors":"Ming Yang,&nbsp;Xia Li,&nbsp;Bo Wang,&nbsp;Xian Liu,&nbsp;Bo Zhang,&nbsp;Xue-Pin Liao","doi":"10.1186/s42825-024-00183-5","DOIUrl":"10.1186/s42825-024-00183-5","url":null,"abstract":"<div><p>The efficient biosynthesis is important for the sustainable development of lignocellulosic ethanol industry, but it is limited by furfural stress produced with cellulose pretreatment. Collagen peptide (CP), as an affluent protein resource, considerably improved the tolerance of <i>Saccharomyces cerevisiae</i> against furfural stress. When the furfural concentration was 2 g/L, the residual sugar concentration was reduced from 122.39 to 8.90 g/L, and the final ethanol yield increased from 30.69 to 87.27 g/L in the presence of CP. In addition, the ethanol yield in CP containing media was higher than those in other peptides. Transcriptome analysis showed CP can improve the expression of genes (<i>FBA1</i>, <i>PDC1</i>, <i>PDC6</i>, and <i>ENO1</i>) associated with glycolysis to promote sugar utilization, and enhance ethanol biosynthesis under furfural stress, which were further verified by quantitative real-time PCR. These results indicated that CP is a promising protectant and accelerator for bioethanol biosynthesis.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":640,"journal":{"name":"Journal of Leather Science and Engineering","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://JLSE.SpringerOpen.com/counter/pdf/10.1186/s42825-024-00183-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143107850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ethylene vinyl acetate as a multifunctional compatibilizer for natural rubber/cis-1,4-polybutadiene rubber blends with enhanced compatibility, filler dispersion and mechanical properties
Journal of Leather Science and Engineering Pub Date : 2025-02-01 DOI: 10.1186/s42825-024-00181-7
Jiyu Liang, Jianhui Wu, Chunhua Wang, Jun Sang, Keshuai Ren, To Ngai, Wei Lin
{"title":"Ethylene vinyl acetate as a multifunctional compatibilizer for natural rubber/cis-1,4-polybutadiene rubber blends with enhanced compatibility, filler dispersion and mechanical properties","authors":"Jiyu Liang,&nbsp;Jianhui Wu,&nbsp;Chunhua Wang,&nbsp;Jun Sang,&nbsp;Keshuai Ren,&nbsp;To Ngai,&nbsp;Wei Lin","doi":"10.1186/s42825-024-00181-7","DOIUrl":"10.1186/s42825-024-00181-7","url":null,"abstract":"<div><p>The blending of natural rubber (NR) with <i>cis</i>-1,4-polybutadiene rubber (BR) has gained widespread attention due to its potential in enhancing the low temperature resistance and abrasion resistance of NR. However, the incompatibility between NR and BR as well as the non-uniform distribution of fillers often have an adverse impact on the mechanical properties. Herein, we propose a facile approach to modulate the multi-scale structures in NR/BR blends including polymer compatibility and filler distribution by introducing ethylene vinyl acetate (EVA) with varying vinyl acetate (VA) content as multifunctional compatibilizers. The results indicate that the cure characteristics (i.e., processability) and mechanical properties of NR/BR blends can be readily tailored through adjustment of the VA content in EVA. When the VA content in EVA is increased to 18% (EVA-18), the NR/BR blends simultaneously exhibit favorable processability and mechanical properties. The microstructural analysis demonstrates that the introduction of EVA-18 not only enhances the compatibility between NR and BR with significantly reduced domain size, but also improves fillers dispersion in the rubber matrix. The presence of EVA-18 at concentrations up to 20 parts per hundred of rubber (phr) in NR/BR vulcanizates improves the mechanical properties by approximately 24% compared to un-compatibilized NR/BR vulcanizates, which is superior to the most present studies. This work will be beneficial for the development of NR/BR blends in the industry and provide a guideline for designing efficient compatibilizers for other immiscible rubber blends.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":640,"journal":{"name":"Journal of Leather Science and Engineering","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://JLSE.SpringerOpen.com/counter/pdf/10.1186/s42825-024-00181-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143107776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of cinnamon essential oil-loaded Pickering emulsions stabilized by chitosan/gelatin nanoparticles with enhanced antibacterial and antibiofilm actives 壳聚糖/明胶纳米颗粒稳定肉桂精油皮克林乳剂的研制,增强其抗菌和抗生物膜活性
Journal of Leather Science and Engineering Pub Date : 2025-01-03 DOI: 10.1186/s42825-024-00180-8
Zhilang Xu, Xinxin Wang, Huaqian Liang, Xinying Li, Derong Li, Changdao Mu, Liming Ge, Defu Li
{"title":"Development of cinnamon essential oil-loaded Pickering emulsions stabilized by chitosan/gelatin nanoparticles with enhanced antibacterial and antibiofilm actives","authors":"Zhilang Xu,&nbsp;Xinxin Wang,&nbsp;Huaqian Liang,&nbsp;Xinying Li,&nbsp;Derong Li,&nbsp;Changdao Mu,&nbsp;Liming Ge,&nbsp;Defu Li","doi":"10.1186/s42825-024-00180-8","DOIUrl":"10.1186/s42825-024-00180-8","url":null,"abstract":"<div><p>Bacterial biofilm infection is a complicated and important global problem. Non-toxic biomass-based Pickering emulsions as an essential oil delivery system are a potentially effective means in biofilm treatment. Herein, the chitosan/gelatin complex nanoparticles (CGNPs) stabilized Pickering (CGP) emulsion loaded with <i>cinnamon essential oil</i> (CEO) was developed to inhibit and remove bacterial biofilms. CGNPs were initially successfully prepared with a particle size of 253.7 nm. Subsequently, CGP emulsions were prepared using CGNPs as the emulsifier and CEO as the oil phase, with the aqueous phase pH value of 5.5 and ionic strength of 50 mM. Amino groups of CGNPs were crosslinked with the aldehyde group of CEO via Schiff base reaction at the oil–water interface to form a denser core–shell structure, thus improving the stability of Pickering emulsion. The CGP emulsions exhibit controlled and long-term sustained release properties in essential oil delivery, with 89.8%, 81.0%, and 62.2% CEO release within 168 h for CGP-0.1, CGP-0.2, and CGP-0.3, respectively. Moreover, CGP emulsions have stronger antioxidant activities (nearly 100%), broad-spectrum antibacterial activities (&gt; 90%), enhanced penetration and removal capabilities against preformed biofilms than single CEO or CGNPs, as well as its better biocompatibility than conventional surfactant-stabilized emulsions. Hence, CEO-delivered CGP emulsion could serve as a potential strategy against biofilm infections and bacterial resistance.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":640,"journal":{"name":"Journal of Leather Science and Engineering","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://JLSE.SpringerOpen.com/counter/pdf/10.1186/s42825-024-00180-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142912806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A novel recycling technology for chrome shavings: efficient separation of chromium and collagen fibers based on swelling inhibition in alkali-acid processing 一种新的铬屑回收技术:碱酸处理中基于抑制溶胀的铬和胶原纤维的有效分离
Journal of Leather Science and Engineering Pub Date : 2025-01-02 DOI: 10.1186/s42825-024-00182-6
Honghong Chen, Minghui Li, Sadaqat Ali Chattha, Xu Zhang, Biyu Peng, Chunxiao Zhang
{"title":"A novel recycling technology for chrome shavings: efficient separation of chromium and collagen fibers based on swelling inhibition in alkali-acid processing","authors":"Honghong Chen,&nbsp;Minghui Li,&nbsp;Sadaqat Ali Chattha,&nbsp;Xu Zhang,&nbsp;Biyu Peng,&nbsp;Chunxiao Zhang","doi":"10.1186/s42825-024-00182-6","DOIUrl":"10.1186/s42825-024-00182-6","url":null,"abstract":"<div><p>Dechroming techniques with a low degree of collagen hydrolysis and a high degree of dechroming are more suitable for the resource utilization of chrome shavings. However, achieving efficient simultaneous separation of chromium and collagen fibers is challenging because swollen collagen fibers absorb a large amount of chromium-containing water and are prone to hydrolysis after dechroming. This study investigated the correlation between the swelling inhibition of collagen fibers and the extent of dechroming and optimized the process parameters. The results demonstrated that the incorporation of neutral salt significantly increased the rate of dechroming and reduced the degree of collagen hydrolysis. The optimized alkali-acid-washing process was as follows: soaking in a Na<sub>2</sub>SO<sub>4</sub> solution (4%, w/w), dechroming with a NaOH solution at pH 13.5, rapidly adjusting the pH of reactants to 1.0 with an H<sub>2</sub>SO<sub>4</sub> solution, pressure filtration, washing the filtered residue with 5% Na<sub>2</sub>SO<sub>4</sub> solution (w/w) at pH 1.0, followed by pressure filtration. After two cycles of the alkali-acid-washing process, the filtered residue was washed with an oxalic acid-Na<sub>2</sub>SO<sub>4</sub> solution (5%, w/w) and pressure-filtered again. The chromium content of recovered collagen was reduced to 34.0 mg/kg. The degree of collagen hydrolysis was confined to 9% with the fiber morphology completely retained. The wastewater chromium content was reduced to 0.4 mg/L after the simple precipitation, meeting the direct discharge requirement. The recycled chrome was utilized as chrome-tanning agent. These results suggested that the established method could be a promising resource reutilization route for the sustainable development of the leather industry.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":640,"journal":{"name":"Journal of Leather Science and Engineering","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://JLSE.SpringerOpen.com/counter/pdf/10.1186/s42825-024-00182-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142912811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The study on multi-defect detection for leather using object detection techniques 基于目标检测技术的皮革多缺陷检测研究
Journal of Leather Science and Engineering Pub Date : 2024-12-31 DOI: 10.1186/s42825-024-00186-2
Hasan Onur Ataç, Ahmet Kayabaşı, M. Fatih Aslan
{"title":"The study on multi-defect detection for leather using object detection techniques","authors":"Hasan Onur Ataç,&nbsp;Ahmet Kayabaşı,&nbsp;M. Fatih Aslan","doi":"10.1186/s42825-024-00186-2","DOIUrl":"10.1186/s42825-024-00186-2","url":null,"abstract":"<div><p>Leather has played a very important role in human life for thousands of years. Ensuring the quality of leather and addressing surface defects poses significant challenges. Traditionally, human inspectors are responsible for detecting surface defects in tanneries, but this approach is labor-intensive and susceptible to human error. As a result, there is a growing demand for automated systems to detect the defects. Herein, artificial intelligence (AI) was developed to detect the defects on leather surfaces. Six targeted defect types, denoted as insect bites, scratches, holes, stitch marks, diseased and ruptures, were specifically addressed to enhance the overall quality assessment process. AI-based vision techniques were used to detect flaws on the leather on photographs taken with a high-resolution camera. Deep learning algorithms Mask R-CNN, YOLOv8 and within the framework of Detectron2, RetinaNet R101 3x, Faster R-CNN R101-FPN 3x models were performed and a comparison was made between these algorithms. By using the slicing aided hyper-inference (SAHI) algorithm in coordination with these algorithms, the detection rates of small defects on the images were increased. The highest accuracy rate was achieved when the YOLOv8 algorithm had 75 epoch values for training, and the SAHI algorithm had slice height-width values of 256 × 256 pixels.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":640,"journal":{"name":"Journal of Leather Science and Engineering","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://JLSE.SpringerOpen.com/counter/pdf/10.1186/s42825-024-00186-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142906064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Collagen-based materials in male genitourinary diseases and tissue regeneration 胶原基材料在男性泌尿生殖系统疾病和组织再生中的应用
Journal of Leather Science and Engineering Pub Date : 2024-12-18 DOI: 10.1186/s42825-024-00185-3
Fangyuan Li,  XinHuang, Ruiying Wang, Yujing Li, Lukanxuan Wu, Xinyu Qiao, Yuchan Zhong, Guidong Gong, Wei Huang
{"title":"Collagen-based materials in male genitourinary diseases and tissue regeneration","authors":"Fangyuan Li,&nbsp; XinHuang,&nbsp;Ruiying Wang,&nbsp;Yujing Li,&nbsp;Lukanxuan Wu,&nbsp;Xinyu Qiao,&nbsp;Yuchan Zhong,&nbsp;Guidong Gong,&nbsp;Wei Huang","doi":"10.1186/s42825-024-00185-3","DOIUrl":"10.1186/s42825-024-00185-3","url":null,"abstract":"<div><p>Male genitourinary dysfunction causes serious physical or mental distress, such as infertility and psychological harm, which leads to impaired quality of life. Current conventional treatments involving drug therapy, surgical repair, and tissue grafting have a limited effect on recovering the function and fertility of the genitourinary organs. To address these limitations, various biomaterials have been explored, with collagen-based materials increasingly gaining attention for reconstructing the male genitourinary system due to their superior biocompatibility, biodegradability, low antigenicity, biomimetic 3D matrix characteristics, hemostatic efficacy, and tissue regeneration capabilities. This review covers the recent biomedical applications of collagen-based materials including treatment of erectile dysfunction, premature ejaculation, penile girth enlargement, prostate cancer, Peyronie's disease, chronic kidney disease, etc. Although there are relatively few clinical trials, the promising results of the existing studies on animal models reveal a bright future for collagen-based materials in the treatment of male genitourinary diseases.</p><h3>Graphic Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":640,"journal":{"name":"Journal of Leather Science and Engineering","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://JLSE.SpringerOpen.com/counter/pdf/10.1186/s42825-024-00185-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142844791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The chondrogenic differentiation of BMSCs in collagen hydrogels and the effect of MMPs among cell-material interactions 胶原水凝胶中骨髓间充质干细胞的成软骨分化及基质蛋白酶在细胞-物质相互作用中的作用
Journal of Leather Science and Engineering Pub Date : 2024-12-01 DOI: 10.1186/s42825-024-00176-4
Yajun Tang, Jing Wang, He Qiu, Yang Xu, Zhanhong Liu, Lu Song, Hai Lin, Xingdong Zhang
{"title":"The chondrogenic differentiation of BMSCs in collagen hydrogels and the effect of MMPs among cell-material interactions","authors":"Yajun Tang,&nbsp;Jing Wang,&nbsp;He Qiu,&nbsp;Yang Xu,&nbsp;Zhanhong Liu,&nbsp;Lu Song,&nbsp;Hai Lin,&nbsp;Xingdong Zhang","doi":"10.1186/s42825-024-00176-4","DOIUrl":"10.1186/s42825-024-00176-4","url":null,"abstract":"<div><p>The purpose of this study was to investigate the influence of the advanced structure of collagen on the chondrogenic differentiation of BMSCs encapsulated in collagen hydrogels, with an emphasis on MMPs which might affect the cell-material interactions. Collagen and gelatin-based hydrogels with comparable physicochemical properties but mainly distinctive in molecular structure were prepared and further utilized to load BMSCs to study the chondrogenesis. The detection results of MMPs in hydrogels with and without TIMP at both gene and protein levels suggested that MMPs were involved in cell recognition, adhesion, migration, proliferation and further remodeling of cell microenvironment. The chondrogenic gene detection, histological observation and extracellular matrix analysis indicated that the BMSCs were well differentiated into chondrocytes and maintained the phenotypes in collagen hydrogels (C group) which preserved the native structures, comparing with those results acquired from gelatin hydrogels (G group). Finally, the expression of several integrin subunits was investigated to analyze the connection of these cell membrane surface proteins and microenvironment remodeled by MMPs in collagen and gelatin hydrogels. The conclusion was drawn that the advanced structure of collagen affected the chondrogenesis of BMSCs via the cell-material interactions, among which MMPs were one of the major factors crucial to form appropriate microenvironment to modulate the BMSCs fate.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":640,"journal":{"name":"Journal of Leather Science and Engineering","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://JLSE.SpringerOpen.com/counter/pdf/10.1186/s42825-024-00176-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142754228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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