Journal of Leather Science and Engineering最新文献

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Characterization of recombinant humanized collagen type III and its influence on cell behavior and phenotype 重组人源ⅲ型胶原蛋白的表征及其对细胞行为和表型的影响
Journal of Leather Science and Engineering Pub Date : 2022-12-01 DOI: 10.1186/s42825-022-00103-5
Jing Wang, Hong Hu, Jian Wang, He Qiu, Yongli Gao, Yang Xu, Zhanhong Liu, Yajun Tang, Lu Song, John Ramshaw, Hai Lin, Xingdong Zhang
{"title":"Characterization of recombinant humanized collagen type III and its influence on cell behavior and phenotype","authors":"Jing Wang,&nbsp;Hong Hu,&nbsp;Jian Wang,&nbsp;He Qiu,&nbsp;Yongli Gao,&nbsp;Yang Xu,&nbsp;Zhanhong Liu,&nbsp;Yajun Tang,&nbsp;Lu Song,&nbsp;John Ramshaw,&nbsp;Hai Lin,&nbsp;Xingdong Zhang","doi":"10.1186/s42825-022-00103-5","DOIUrl":"10.1186/s42825-022-00103-5","url":null,"abstract":"<div><p>Collagen made a tremendous impact in the field of regenerative medicine as a bioactive material. For decades, collagen has been used not only as a scaffolding material but also as an active component in regulating cells' biological behavior and phenotype. However, animal-derived collagen as a major source suffered from problems of immunogenicity, risk of viral infection, and the unclear relationship between bioactive sequence and function. Recombinant humanized collagen (rhCol) provided alternatives for regenerative medicine with more controllable risks. However, the characterization of rhCol and the interaction between rhCol and cells still need further investigation, including cell behavior and phenotype. The current study preliminarily demonstrated that recombinant humanized collagen type III (rhCol III) conformed to the theoretical amino acid sequence and had an advanced structure resembling bovine collagen. Furthermore, rhCol III could facilitate basal biological behaviors of human skin fibroblasts, such as adhesion, proliferation and migration. rhCol III was beneficial for some extracellular matrix-expressing cell phenotypes. The study would shed light on the mechanism research of rhCol and cell interactions and further understanding of effectiveness in tissue regeneration.\u0000</p><h3>Graphical abstract</h3>\u0000 <div><figure><div><div><picture><source><img></source></picture></div></div></figure></div>\u0000 </div>","PeriodicalId":640,"journal":{"name":"Journal of Leather Science and Engineering","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://JLSE.SpringerOpen.com/counter/pdf/10.1186/s42825-022-00103-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73312119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Advanced application of collagen-based biomaterials in tissue repair and restoration 胶原基生物材料在组织修复和修复中的先进应用
Journal of Leather Science and Engineering Pub Date : 2022-11-07 DOI: 10.1186/s42825-022-00102-6
Jiayi Zhu, Zhulian Li, Yaping Zou, Gonggong Lu, Alfredo Ronca, Ugo D’Amora, Jie Liang, Yujiang Fan, Xingdong Zhang, Yong Sun
{"title":"Advanced application of collagen-based biomaterials in tissue repair and restoration","authors":"Jiayi Zhu,&nbsp;Zhulian Li,&nbsp;Yaping Zou,&nbsp;Gonggong Lu,&nbsp;Alfredo Ronca,&nbsp;Ugo D’Amora,&nbsp;Jie Liang,&nbsp;Yujiang Fan,&nbsp;Xingdong Zhang,&nbsp;Yong Sun","doi":"10.1186/s42825-022-00102-6","DOIUrl":"10.1186/s42825-022-00102-6","url":null,"abstract":"<div><p>In tissue engineering, bioactive materials play an important role, providing structural support, cell regulation and establishing a suitable microenvironment to promote tissue regeneration. As the main component of extracellular matrix, collagen is an important natural bioactive material and it has been widely used in scientific research and clinical applications. Collagen is available from a wide range of animal origin, it can be produced by synthesis or through recombinant protein production systems. The use of pure collagen has inherent disadvantages in terms of physico-chemical properties. For this reason, a processed collagen in different ways can better match the specific requirements as biomaterial for tissue repair. Here, collagen may be used in bone/cartilage regeneration, skin regeneration, cardiovascular repair and other fields, by following different processing methods, including cross-linked collagen, complex, structured collagen, mineralized collagen, carrier and other forms, promoting the development of tissue engineering. This review summarizes a wide range of applications of collagen-based biomaterials and their recent progress in several tissue regeneration fields. Furthermore, the application prospect of bioactive materials based on collagen was outlooked, aiming at inspiring more new progress and advancements in tissue engineering research.</p><h3>Graphical Abstract</h3>\u0000 <div><figure><div><div><picture><source><img></source></picture></div></div></figure></div>\u0000 </div>","PeriodicalId":640,"journal":{"name":"Journal of Leather Science and Engineering","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://JLSE.SpringerOpen.com/counter/pdf/10.1186/s42825-022-00102-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81482422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 18
Polyphenol based hybrid nano-aggregates modified collagen fibers of biological valve leaflets to achieve enhanced mechanical, anticoagulation and anti-calcification properties 多酚基杂化纳米聚集体修饰生物瓣膜小叶的胶原纤维,实现增强的机械、抗凝血和抗钙化性能
Journal of Leather Science and Engineering Pub Date : 2022-10-23 DOI: 10.1186/s42825-022-00105-3
Shufen Li, Shiying Lang, Zhiqian Chen, Jingruo Chen, Weihua Zhuang, Yangrui Du, Yawen Yao, Gongyan Liu, Mao Chen
{"title":"Polyphenol based hybrid nano-aggregates modified collagen fibers of biological valve leaflets to achieve enhanced mechanical, anticoagulation and anti-calcification properties","authors":"Shufen Li,&nbsp;Shiying Lang,&nbsp;Zhiqian Chen,&nbsp;Jingruo Chen,&nbsp;Weihua Zhuang,&nbsp;Yangrui Du,&nbsp;Yawen Yao,&nbsp;Gongyan Liu,&nbsp;Mao Chen","doi":"10.1186/s42825-022-00105-3","DOIUrl":"10.1186/s42825-022-00105-3","url":null,"abstract":"<div><p>Glutaraldehyde (Glut)-crosslinked porcine pericardium and bovine pericardium are mainly consisted of collagen and widely used for the preparation of heterogenous bioprosthetic heart valves (BHV), which play an important role in the replacement therapy of severe valvular heart disease, while their durability is limited by degeneration due to calcification, thrombus, endothelialization difficulty and prosthetic valve endocarditis. Herein, we develop a novel BHV, namely, TPly-BP, based on natural tannic acid and polylysine to improve the durability of Glut crosslinked bovine pericardium (Glut-BP). Impressively, tannic acid and polylysine could form nanoaggregates via multiple hydrogen bonds and covalent bonds, and the introduction of nanoaggregates not only improved the mechanical properties and collagen stability but also endowed TPly-BP with good biocompatibility and hemocompatibility. Compared to Glut-BP, TPly-BP showed significantly reduced cytotoxicity, improved endothelial cell adhesion, a low hemolysis ratio and obviously reduced platelet adhesion. Importantly, TPly-BP exhibited great antibacterial and in vivo anti-calcification ability, which was expected to improve the in vivo durability of BHVs. These results suggested that TPly-BP would be a potential candidate for BHV.</p><h3>Graphical abstract</h3>\u0000 <div><figure><div><div><picture><source><img></source></picture></div></div></figure></div>\u0000 </div>","PeriodicalId":640,"journal":{"name":"Journal of Leather Science and Engineering","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://JLSE.SpringerOpen.com/counter/pdf/10.1186/s42825-022-00105-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120466018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Polyphenol based hybrid nano-aggregates modified collagen fibers of biological valve leaflets to achieve enhanced mechanical, anticoagulation and anti-calcification properties 多酚基杂化纳米聚集体修饰生物瓣膜小叶的胶原纤维,实现增强的机械、抗凝血和抗钙化性能
Journal of Leather Science and Engineering Pub Date : 2022-10-23 DOI: 10.1186/s42825-022-00105-3
Shufen Li, Shiying Lang, Zhiqian Chen, Jing-Heng Chen, Weihua Zhuang, Yangrui Du, Yawen Yao, Gongyan Liu, Mao Chen
{"title":"Polyphenol based hybrid nano-aggregates modified collagen fibers of biological valve leaflets to achieve enhanced mechanical, anticoagulation and anti-calcification properties","authors":"Shufen Li, Shiying Lang, Zhiqian Chen, Jing-Heng Chen, Weihua Zhuang, Yangrui Du, Yawen Yao, Gongyan Liu, Mao Chen","doi":"10.1186/s42825-022-00105-3","DOIUrl":"https://doi.org/10.1186/s42825-022-00105-3","url":null,"abstract":"","PeriodicalId":640,"journal":{"name":"Journal of Leather Science and Engineering","volume":"11 1","pages":"1-15"},"PeriodicalIF":0.0,"publicationDate":"2022-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87832884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Optimization and application of UVC irradiation for prevention of fungal biodeterioration of vegetable tanned and chrome tanned leather 紫外线照射防止植物鞣革和铬鞣革真菌生物变质的优化及应用
Journal of Leather Science and Engineering Pub Date : 2022-10-21 DOI: 10.1186/s42825-022-00104-4
Eshita Jhahan, Subarna Bhattacharyya, Anirban Chaudhuri, Nirmal Sarkar, Shaheen Akhtar, Punarbasu Chaudhuri
{"title":"Optimization and application of UVC irradiation for prevention of fungal biodeterioration of vegetable tanned and chrome tanned leather","authors":"Eshita Jhahan,&nbsp;Subarna Bhattacharyya,&nbsp;Anirban Chaudhuri,&nbsp;Nirmal Sarkar,&nbsp;Shaheen Akhtar,&nbsp;Punarbasu Chaudhuri","doi":"10.1186/s42825-022-00104-4","DOIUrl":"10.1186/s42825-022-00104-4","url":null,"abstract":"<div><p>UV-C irradiation critically effects the growth of micro-fungi and also deteriorate leather materials. In the present study vegetable tanned and chrome tanned leather were infected with pure cultures of <i>Aspergillus niger</i> and <i>Aspergillus flavu</i>s, which were isolated from stored leather materials. UV-C light (λ = 254 nm) was applied on infected leather for 15 and 60 min. The changes in leather qualities were examined through weight, tensile strength, scanning electron microscope, energy dispersive X-ray and Fourier transform infrared spectroscopy study after 15 and 30 days of fungal inoculation. Vegetable tanned leather was more vulnerable in case of fungal attack than chrome tanned leather while <i>A. flavus</i> showed more influence on leather deterioration than <i>A. niger.</i> The results showed that weight loss after 30 days for 15 and 60 min irradiation exposure was 1.3% compared to <i>A. flavus</i> infected leather (3.93%). The tensile strength of vegetable and chrome tanned UV irradiated leather was increased by 44% and 7% respectively. The scanning electron microscopic images exhibit the limited presence of conidiophores in UV-C exposed leather which confirmed the potentiality of irradiation for controlling fungal growth. The infrared spectral analysis of UV-C exposed infected leather samples showed neither shifting of wavenumber nor displacement of any functional groups. Altogether the efficacy of UV-C irradiation against biodeterioration of leather was concluded to be effective. This method can be used to control fungal growth without compromising the leather quality.</p><h3>Graphical Abstract</h3>\u0000 <div><figure><div><div><picture><source><img></source></picture></div></div></figure></div>\u0000 </div>","PeriodicalId":640,"journal":{"name":"Journal of Leather Science and Engineering","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://JLSE.SpringerOpen.com/counter/pdf/10.1186/s42825-022-00104-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88056315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Organosilicon leather coating technology based on carbon peak strategy 基于碳峰策略的有机硅皮革涂层技术
Journal of Leather Science and Engineering Pub Date : 2022-10-19 DOI: 10.1186/s42825-022-00101-7
Wenkai Wang, Haojun Fan, Lijiang Song, Zhenya Wang, Heng Li, Jun Xiang, Qiang Huang, Xiangquan Chen
{"title":"Organosilicon leather coating technology based on carbon peak strategy","authors":"Wenkai Wang,&nbsp;Haojun Fan,&nbsp;Lijiang Song,&nbsp;Zhenya Wang,&nbsp;Heng Li,&nbsp;Jun Xiang,&nbsp;Qiang Huang,&nbsp;Xiangquan Chen","doi":"10.1186/s42825-022-00101-7","DOIUrl":"10.1186/s42825-022-00101-7","url":null,"abstract":"<div><p>Based on the demand of carbon peak and carbon emission reduction strategy, divinyl-terminated polydimethylsiloxane (<sup>Vi</sup>PDMS<sup>Vi</sup>), poly(methylhydrosiloxane) (PMHS), divinyl-terminated polymethylvinylsiloxane (<sup>Vi</sup>PMVS<sup>Vi</sup>), and fumed silica were used as primary raw materials, polydimethylsiloxane (PDMS) synthetic leather coating was in situ constructed by thermally induced hydrosilylation polymerization on the synthetic leather substrate. The effect of the viscosity of <sup>Vi</sup>PDMS<sup>Vi</sup>, the active hydrogen content of PMHS, the molar ratio of vinyl groups to active hydrogen, the dosage of <sup>Vi</sup>PMVS<sup>Vi</sup> and fumed silica on the performance of PDMS polymer coating, including mechanical properties, cold resistance, flexural resistance, abrasion resistance, hydrophobic and anti-fouling properties were investigated. The results show that <sup>Vi</sup>PDMS<sup>Vi</sup> with high vinyl content and PMHS with low active hydrogen content is more conducive to obtaining organosilicon coating with better mechanical properties, the optimized dosage of <sup>Vi</sup>PMVS<sup>Vi</sup> and fumed silica was 7 wt% and 40 wt%, respectively. In this case, the tensile strength and the broken elongation of the PDMS polymer coating reached 5.96 MPa and 481%, showing reasonable mechanical properties for leather coating. Compared with polyurethane based or polyvinyl chloride based synthetic leather, the silicon based synthetic leather prepared by this method exhibits excellent cold resistance, abrasion resistance, super hydrophobicity, and anti-fouling characteristics.</p><h3>Graphical Abstract</h3>\u0000 <div><figure><div><div><picture><source><img></source></picture></div></div></figure></div>\u0000 </div>","PeriodicalId":640,"journal":{"name":"Journal of Leather Science and Engineering","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://JLSE.SpringerOpen.com/counter/pdf/10.1186/s42825-022-00101-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74796761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
The improvement of dispersity, thermal stability and mechanical properties of collagen fibers by silane modification: an exploration for developing new leather making technology 硅烷改性提高胶原纤维的分散性、热稳定性和力学性能:开发皮革新工艺的探索
Journal of Leather Science and Engineering Pub Date : 2022-09-14 DOI: 10.1186/s42825-022-00100-8
Shuangfeng Xu, Hanzhong Xiao, Bi Shi
{"title":"The improvement of dispersity, thermal stability and mechanical properties of collagen fibers by silane modification: an exploration for developing new leather making technology","authors":"Shuangfeng Xu,&nbsp;Hanzhong Xiao,&nbsp;Bi Shi","doi":"10.1186/s42825-022-00100-8","DOIUrl":"10.1186/s42825-022-00100-8","url":null,"abstract":"<div><p>The effect of hydrophobic modification on the performances of collagen fibers (CFs) was investigated by using silane coupling agents with different alkyl chains as hydrophobic modifiers. It was found silane could be easily grafted onto CF surface through covalent bonds under 5% water content. This modification led to the transformation of surface wettability of CF from hydrophilic to hydrophobic. Interestingly, the change of surface wettability resulted in substantial improvement of the modified CF properties, presenting well dispersity of collagen fibers, higher thermal stability and enhanced mechanical properties in comparison with natural CF. The degree of improvement mainly depended on the length of alkyl chain in silane. Longer alkyl chain produced strong hydrophobicity and subsequently more superior performances of the modified CF. When the length of alkyl chain increased to 18 carbon atoms, the modified CF possessed durable superhydrophobicity even exposed to aqueous solutions of different pH, UV, and organic solvents, and had excellent thermal and mechanical properties like leather fibers. In general, this work clearly revealed that the properties of CF are closely and positively related to the hydrophobicity, which is suggestive in developing new leather making technology.</p><h3>Graphical Abstract</h3>\u0000 <div><figure><div><div><picture><source><img></source></picture></div></div></figure></div>\u0000 </div>","PeriodicalId":640,"journal":{"name":"Journal of Leather Science and Engineering","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://JLSE.SpringerOpen.com/counter/pdf/10.1186/s42825-022-00100-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89940576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
A review on room-temperature self-healing polyurethane: synthesis, self-healing mechanism and application 室温自愈聚氨酯的研究进展:合成、自愈机理及应用
Journal of Leather Science and Engineering Pub Date : 2022-08-30 DOI: 10.1186/s42825-022-00097-0
Yupeng Li, Yong Jin, Wuhou Fan, Rong Zhou
{"title":"A review on room-temperature self-healing polyurethane: synthesis, self-healing mechanism and application","authors":"Yupeng Li,&nbsp;Yong Jin,&nbsp;Wuhou Fan,&nbsp;Rong Zhou","doi":"10.1186/s42825-022-00097-0","DOIUrl":"10.1186/s42825-022-00097-0","url":null,"abstract":"<div><p>Polyurethanes have been widely used in many fields due to their remarkable features such as excellent mechanical strength, good abrasion resistance, toughness, low temperature flexibility, etc. In recent years, room-temperature self-healing polyurethanes have been attracting broad and growing interest because under mild conditions, room-temperature self-healing polyurethanes can repair damages, thereby extending their lifetimes and reducing maintenance costs. In this paper, the recent advances of room-temperature self-healing polyurethanes based on dynamic covalent bonds, noncovalent bonds and combined dual or triple dynamic bonds are reviewed, focusing on their synthesis methods and self-healing mechanisms, and their mechanical properties, healing efficiency and healing time are also described in detial. In addition, the latest applications of room-temperature self-healing polyurethanes in the fields of leather coatings, photoluminescence materials, flexible electronics and biomaterials are summarized. Finally, the current challenges and future development directions of the room-temprature self-healing polyurethanes are highlighted. Overall, this review is expected to provide a valuable reference for the prosperous development of room-temperature self-healing polyurethanes.</p><h3>Graphical abstract</h3>\u0000 <div><figure><div><div><picture><source><img></source></picture></div></div></figure></div>\u0000 </div>","PeriodicalId":640,"journal":{"name":"Journal of Leather Science and Engineering","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://JLSE.SpringerOpen.com/counter/pdf/10.1186/s42825-022-00097-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82799778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Essential role of isoelectric point of skin/leather in leather processing 皮革等电点在皮革加工中的重要作用
Journal of Leather Science and Engineering Pub Date : 2022-08-25 DOI: 10.1186/s42825-022-00099-y
Ya-nan Wang, Longyu Hu
{"title":"Essential role of isoelectric point of skin/leather in leather processing","authors":"Ya-nan Wang,&nbsp;Longyu Hu","doi":"10.1186/s42825-022-00099-y","DOIUrl":"10.1186/s42825-022-00099-y","url":null,"abstract":"","PeriodicalId":640,"journal":{"name":"Journal of Leather Science and Engineering","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://JLSE.SpringerOpen.com/counter/pdf/10.1186/s42825-022-00099-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72432081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Functional non-glutaraldehyde treated porcine pericardium for anti-coagulation, anti-calcification, and endothelial proliferation bioprosthetic heart valves 功能性非戊二醛处理的猪心包用于抗凝血、抗钙化和内皮细胞增殖生物人工心脏瓣膜
Journal of Leather Science and Engineering Pub Date : 2022-08-20 DOI: 10.1186/s42825-022-00098-z
Xiaotong Chen, Tao Yu, Qunshou Kong, Dajun Kuang, Hong Xu, Zhiyu Zhao, Li Yang, Gaocan Li, Haojun Fan, Yunbing Wang
{"title":"Functional non-glutaraldehyde treated porcine pericardium for anti-coagulation, anti-calcification, and endothelial proliferation bioprosthetic heart valves","authors":"Xiaotong Chen,&nbsp;Tao Yu,&nbsp;Qunshou Kong,&nbsp;Dajun Kuang,&nbsp;Hong Xu,&nbsp;Zhiyu Zhao,&nbsp;Li Yang,&nbsp;Gaocan Li,&nbsp;Haojun Fan,&nbsp;Yunbing Wang","doi":"10.1186/s42825-022-00098-z","DOIUrl":"10.1186/s42825-022-00098-z","url":null,"abstract":"<div><p>In the last decade, the number of transcatheter heart valve replacement for severe heart valve disease has increased exponentially. Although the bioprosthetic artificial heart valve (BHV) has similar fluid dynamics performance to the original heart valve compared with mechanical heart valve so that there is no need to take long-term anticoagulant drugs to prevent thromboembolism, transcatheter BHV replacement are still at risk for thrombosis during the first few months according to the clinical data. However, the use of antithrombotic drugs can also increase the risk of bleeding. Therefore, it is particularly important to improve the anticoagulant properties for the BHV itself. In this work, a kind of non-glutaraldehyde cross-linked BHV material with excellent antithrombotic ability has been prepared from carboxylated oxazolidine treated porcine pericardium (consisting of collagen, elastin and glycoprotein) with the further graft of the anticoagulant heparin sodium via hydrophilic modified chitosan. Along with the similar mechanical properties and collagen stability comparable to the glutaraldehyde cross-linked porcine pericardium (PP), these functional non-glutaraldehyde cross-linked PPs exhibit better biocompatibility, promoted endothelial proliferation and superior anti-calcification ability. More importantly, excellent anticoagulant activity can be observed in the hematological experiments in vivo and in vitro. In summary, these excellent performances make these functional non-glutaraldehyde cross-linked PPs great potentialities in the BHV applications.</p><h3>Graphical abstract</h3>\u0000 <div><figure><div><div><picture><source><img></source></picture></div></div></figure></div>\u0000 </div>","PeriodicalId":640,"journal":{"name":"Journal of Leather Science and Engineering","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://JLSE.SpringerOpen.com/counter/pdf/10.1186/s42825-022-00098-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76812321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
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