Emerging Contaminants最新文献

{"title":"Veterinary antibiotics in contaminated animal manure: Fate, removal challenges, and future perspectives on conventional and emerging technologies","authors":"Chen Ding ,&nbsp;Yun Lang ,&nbsp;Liwen Xiao ,&nbsp;Xinmin Zhan ,&nbsp;Lin Shi","doi":"10.1016/j.emcon.2025.100515","DOIUrl":"10.1016/j.emcon.2025.100515","url":null,"abstract":"<div><div>The pollution caused by veterinary antibiotics (VAs) has become a global concern due to their role in promoting antimicrobial resistance in the environment. Animal manure, often referred to as animal slurry, contains substantial amounts of VAs originating from animal urine and feces. Since animal manure is commonly used as a nutrient-rich fertilizer, understanding the degradation of VAs and ensuring their efficient removal are essential for effective manure management. This article critically reviews the emerging technologies effective in VA removal, such as adsorption, membrane separation, advanced oxidation processes, carbonization, and bioelectrochemical systems. While these technologies have been extensively studied for their ability to remove pharmaceuticals from common water and wastewater, their applicability to real manure treatment remains insufficiently explored. This article outlines the challenges associated with each technology, particularly concerning the complex composition of animal manure. It highlights the potential of these technologies as supplementary or post-treatment options to improve VA removal, particularly during periods of high VA usage for therapeutic purposes. Finally, the article offers several recommendations, including advancements in animal manure collection, the importance of VA removal to mitigate antimicrobial resistance, and the potential for integrating multiple technologies to optimize VA removal.</div></div>","PeriodicalId":11539,"journal":{"name":"Emerging Contaminants","volume":"11 3","pages":"Article 100515"},"PeriodicalIF":5.3,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144068462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unleashing the power of receptor-based assay on high-throughput detection: Assessing the feasibility of enzyme-linked immunosorbent assay on large-scale antibiotic monitoring","authors":"Yun Yang ,&nbsp;Jinxin Wang ,&nbsp;Lulu Li ,&nbsp;Haofei Yang ,&nbsp;Yu Quan ,&nbsp;Jason Jia Shun Liao ,&nbsp;Wei Ouyang ,&nbsp;Gang Yu ,&nbsp;Li Ling","doi":"10.1016/j.emcon.2025.100511","DOIUrl":"10.1016/j.emcon.2025.100511","url":null,"abstract":"<div><div>Antibiotics are detected in aquatic environments with heterogeneity in their occurrence and associated risk levels. Thus, high spatiotemporal resolution monitoring in a large scale is essential to better cope with their risks. Mass spectrometry (MS) techniques are sensitive and precise, yet complex, expensive, and time-consuming for antibiotic detection. The enzyme-linked immunosorbent assay (ELISA) is among a mature receptor-based assays that offer a cost-effective alternative and are particularly notable for their high throughput analytical capabilities. However, its high throughput power on environmental monitoring is underutilized. ELISA is remarkably rapid (3800–37,000 tests per day), inexpensive ($1.8 per test, capital costs ranging from $35,000 to $270,000), and ready-to-use (97 commercial kits available) for detecting frequently reported antibiotics. Adopting solid phase extraction decreases their limits of detection to as low as 0.125 ng/L. Their quantification results are robust as they also generally agreed well with those of MS methods. A conservative way at present is to use ELISA for initial screening of large numbers of samples, with subsequent quantification of a small proportion of “positive” samples through MS methods. Yet, the applicability of ELISA can be further improved, such as developing a standardized quantification procedure for ELISA and microfluid chip-based ELISA kits and instruments.</div></div>","PeriodicalId":11539,"journal":{"name":"Emerging Contaminants","volume":"11 3","pages":"Article 100511"},"PeriodicalIF":5.3,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatial distribution of microplastic pollution and its relation to pollution index-based water quality status in Progo River, Indonesia","authors":"Prieskarinda Lestari,&nbsp;Bayu Dwi Apri Nugroho,&nbsp;Hanggar Ganara Mawandha,&nbsp;Chandra Setyawan,&nbsp;Eka Riskawati,&nbsp;Anggraeni Intan Maharani,&nbsp;Brillian Ravi Alvriano,&nbsp;Dhanny Riski Hutama,&nbsp;Nashita Andjani Ludmila Saraswita","doi":"10.1016/j.emcon.2025.100510","DOIUrl":"10.1016/j.emcon.2025.100510","url":null,"abstract":"<div><div>Progo River, one of the largest rivers on Java Island, serves as the primary source of clean water and irrigation for Central Java and the Special Region of Yogyakarta, Indonesia. Despite its importance, the Progo ranks among the top 20 global plastic-polluted rivers. Therefore, the objectives of this study were 1) to investigate spatial distribution and characteristics of microplastic (MP) pollution in the Progo River, and 2) to examine MP relation to the Nemerow Pollution Index (NPI) based water quality status, 15 physicochemical biological water quality parameters, flow velocity and anthropogenic factors, marking the first comprehensive effort in Indonesia. Water and MP samples were collected simultaneously from eight sampling locations. MP abundance in the Progo River ranged from 75.02 to 435.53 particles/m³. The MP characteristics were predominantly large, transparent, film-shaped particles, and identified variably as LDPE, PET, PP, PS, PAA, cellophane. The Pearson Correlation Test results revealed positive correlations between MP abundance and nine water quality parameters (TSS, turbidity, salinity, BOD, COD, phosphate, nitrate, detergent, Cd) and flow velocity. The other six parameters (pH, temperature, TDS, DO, total coliforms, Pb) and two anthropogenic factors (population number and density) were negatively correlated with MP abundance. Notably, DO exhibited a strong and significant negative correlation with MP abundance (<em>r = -0.770, p = 0.043</em>). NPI scores (2.10–16.02) revealed slight to heavy polluted levels in the Progo River and were positively correlated with MP abundance (<em>r=0.336, p=0.461</em>). Multiple Linear Regression analysis (<em>R</em>^<em>2</em> = <em>0.639</em>) identified flow velocity, BOD, COD, turbidity, total coliform, and population number as significant predictors of MP distribution. These findings emphasize the impact of MP pollution on river water quality status, highlighting the need of a novel approach to incorporate MP pollution in periodic water quality assessment to address ecological risks.</div></div>","PeriodicalId":11539,"journal":{"name":"Emerging Contaminants","volume":"11 3","pages":"Article 100510"},"PeriodicalIF":5.3,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143882356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occurrence of micropollutants and enterobacteria in Ticino Valley: an insight of water contamination in an agricultural area with highly anthropogenic impact","authors":"Aurora Piazza ,&nbsp;Francesca Merlo ,&nbsp;Aseel AbuAlshaar ,&nbsp;Francesca Piscopiello ,&nbsp;Federica Maraschi ,&nbsp;Alice Bernini ,&nbsp;Melissa Spalla ,&nbsp;Michela Sturini ,&nbsp;Roberta Migliavacca ,&nbsp;Giorgio Pilla ,&nbsp;Antonella Profumo","doi":"10.1016/j.emcon.2025.100509","DOIUrl":"10.1016/j.emcon.2025.100509","url":null,"abstract":"<div><div>This study investigates the groundwater quality of an aquifer located in medium-populated area of the Ticino Valley with strong agricultural vocation. Two monitoring campaigns were carried out according to the phases of rice cultivation (pre- and post-flooding) on the subsurface and surface irrigation network, Ticino River and wastewater effluents, highlighting a diffuse contamination. The isotopic analyses evidenced mixing phenomena, with both contributions from local rainfall and irrigation network. Combining chemical and microbiological approaches, the anthropogenic impact was evaluated by analysing a selection of traditional and emerging pollutants, such as pesticides, antibiotics and hormones, and assessing the extent of enterobacterial contamination and potential antibiotic resistance genes. Most of the investigated contaminants were found in concentrations from 0.1 ng/L to 632 ng/L, with the exception of Glyphosate and AMPA up to 5 and 20 μg/L, respectively. Even at these low concentrations, contamination of water resources is a serious issue because long-term exposure to such pollutants may cause detrimental effects. The most frequently detected pesticide was the fungicide Tricyclazole, while glucocorticoid Dexamethasone was the most frequent steroid hormone. Noteworthy is the ubiquity of Trimethoprim and a recurrent presence of fluoroquinolones. The occurrence of antibiotics at most sites, although at very low levels, is of environmental and public health concern, as they exert a selective pressure on bacterial populations, allowing the development of antibiotic resistant microbes, as highlighted by microbiological investigations. Indeed, a high microbial load was found in both campaigns, in particular in those sampling sites close to wastewater treatment plants, with the β-lactams and quinolones classes of antibiotics as the most affected by the phenomenon of resistance.</div></div>","PeriodicalId":11539,"journal":{"name":"Emerging Contaminants","volume":"11 3","pages":"Article 100509"},"PeriodicalIF":5.3,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotic resistance occurrence and ecological impact in landfill leachate: A review on compound effect of antibiotics and non-antibiotics","authors":"Yongtao Xu ,&nbsp;Dan Li ,&nbsp;Ying Yuan ,&nbsp;Fei Fang ,&nbsp;Beidou Xi ,&nbsp;Wenbing Tan","doi":"10.1016/j.emcon.2025.100508","DOIUrl":"10.1016/j.emcon.2025.100508","url":null,"abstract":"<div><div>Landfilling remains one of the primary methods for managing municipal solid waste (MSW), processing approximately 350 million tons of waste annually. Among the various components of landfill waste, pharmaceuticals and personal care products (PPCPs), including both antibiotics and non-antibiotic compounds, pose significant environmental challenges. Landfill leachate is a highly complex medium, consisting of diverse contaminants such as non-antibiotic pharmaceuticals (average concentration ∼1.74 μg/L), antibiotics (average concentration ∼527 ng/L), heavy metals, dissolved organic matter, and micro/nano-plastics (concentration range 0.64–2.16 mg/L). This unique mixture can alter the native microbial community structure, profoundly impacting antibiotic resistance, potentially disrupting soil and groundwater ecosystems, and threatening ecological balance. Existing research has extensively investigated the composition, physicochemical properties, environmental behavior, and microbial community structure of landfill leachate, leading to significant advancements in the field. However, due to the complexity and large volume of landfill leachate, current risk assessment approaches predominantly rely on conventional pollutant indicators, and most treatment strategies are designed for general contaminants. There is a lack of systematic descriptions that integrate pollutants with their direct impacts on microbial communities. This review focuses on the current pollution status, spatiotemporal trends, interactions, and migration risks of antibiotics and non-antibiotic pollutants in landfill leachate. In particular, we explore the in situ emergence of antibiotic resistance in landfill leachate (rather than the horizontal transfer of antibiotic resistance genes) and examine the influence of various leachate components on antibiotic resistance. By emphasizing the importance of understanding the combined effects of antibiotics and non-antibiotic pollutants in landfill environments, this review highlights the necessity of long-term ecological risk assessments for antibiotic-induced resistance as an emerging contaminant.</div></div>","PeriodicalId":11539,"journal":{"name":"Emerging Contaminants","volume":"11 3","pages":"Article 100508"},"PeriodicalIF":5.3,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143838363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of anti-androgen cyproterone acetate on sperm characteristics, testosterone level, testicular and liver histology in male goldfish (Carassius auratus)","authors":"Hamed Abdollahpour ,&nbsp;Milad Karimzadeh ,&nbsp;Naghmeh Jafari Pastaki ,&nbsp;Hosseinali Zamani","doi":"10.1016/j.emcon.2025.100507","DOIUrl":"10.1016/j.emcon.2025.100507","url":null,"abstract":"<div><div>Cyproterone acetate (CA), a synthetic anti-androgen, was injected intraperitoneally into fish at two doses (5 and 50 mg/kg body weight) to evaluate its effects on physiological, biochemical, and reproductive parameters. A total of 180 fish were divided into three groups: Control (C), low-dose (LCA), and high-dose (HCA), with two replicates per group. Fish were observed daily for behavior, and water quality was controlled throughout the study. After 28-days of exposure, blood samples were collected to analyze plasma biochemical parameters. Sperm motility, concentration, and histological analyses of testes and liver tissues were also conducted. Results showed a significant dose-dependent decrease in cholesterol, triglycerides, and testosterone levels in the CA-treated groups, with the highest reduction observed in the HCA group (P &lt; 0.05). Sperm motility was significantly reduced in the low-dose (66.1 ± 2.2 %) and high-dose (36.5 ± 3.9 %) groups compared to the control group (79.5 ± 2.2 %). Similarly, sperm concentration and motility time were significantly reduced in the CA-treated groups (P &lt; 0.05). The gonadosomatic index (GSI) also decreased significantly in the treated groups, with the HCA group showing the lowest GSI (P &lt; 0.05), indicating impaired gonadal development. Histological analysis of the testes revealed delayed spermatogenesis, with the HCA group predominantly showing immature gonadal stages (Stage II), and a significant reduction in spermatocytes and spermatozoa. Liver histology indicated necrosis, cell death, blood congestion, and vacuolization in both the LCA and HCA groups, particularly at the high dose (P &lt; 0.05), suggesting hepatotoxicity. In conclusion, CA exerted significant endocrine-disrupting effects in fish, impairing sperm motility, gonadal development, and liver function in a dose-dependent manner. The high-dose treatment caused pronounced effects, including hepatocellular injury and a severe decline in reproductive health. These findings highlight the potential risks of cyproterone acetate as an endocrine disruptor and emphasize the importance of its effects on aquatic species, particularly in ecotoxicological assessments.</div></div>","PeriodicalId":11539,"journal":{"name":"Emerging Contaminants","volume":"11 3","pages":"Article 100507"},"PeriodicalIF":5.3,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143806784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microplastics in settled indoor dust: Implications for human exposure","authors":"Hassan Khalid Ageel,&nbsp;Stuart Harrad,&nbsp;Mohamed Abou-Elwafa Abdallah","doi":"10.1016/j.emcon.2025.100506","DOIUrl":"10.1016/j.emcon.2025.100506","url":null,"abstract":"<div><div>In recent years, microplastics (MPs) occurrence in indoor environments has raised significant concerns due to their distinctive physicochemical properties and potential toxicity. Indoor dust is well-documented as important vector for human exposure to emerging contaminants via inadvertent ingestion. Consequently, the main aim of the present study is to assess human exposure to MPs in settled indoor dust by determining concentrations, and characteristics (size, shape, and polymer type) of MPs in dust samples collected from houses (n = 30) and workplaces (n = 30) in Birmingham, UK. The average MPs concentrations were 155 ± 222 MP/mg in homes, and 125 ± 209 MP/mg in workplaces. Statistical analysis revealed the mean concentration of MPs in the studied homes was significantly higher than that in workplaces, which was attributed mainly to carpeting. In terms of morphology, various shapes of MPs (e.g., fiber, fragment, foam, foil) were identified, with fibres and fragments constituting ∼90 % of the identified MPs in all studied samples. Within the MPs particle size range (10–150 μm) investigated in the current study, the particle size fraction (50–100 μm) was predominant (&gt;49 %) in all the studied samples, followed by particles &gt;100 μm, with fibres having the largest average size (67 μm) among the detected MPs shapes. Polypropylene (PP) and Polyethylene Terephthalate (PET) were the most abundant polymer types in the studied samples, followed by Polyvinyl Chloride (PVC). Typical daily exposures of UK adults and toddlers to MPs through inadvertent ingestion of indoor dust were estimated at 56 and 103 MPs/day. The higher exposure of toddlers was exacerbated by their lower body weight with an estimated typical exposure of 9.7 MP/kg Bw/day, compared to 0.8 MP/kg Bw/day for adults. The higher ingestion exposure to MPs in toddlers raises concern over potential adverse health effects due to their incompletely developed immune and nervous systems.</div></div>","PeriodicalId":11539,"journal":{"name":"Emerging Contaminants","volume":"11 3","pages":"Article 100506"},"PeriodicalIF":5.3,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143806857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges and persistence of contact lenses in wastewater treatment plants: Environmental implications","authors":"Rita Martins- Alves ,&nbsp;Ana Vera Machado ,&nbsp;Fernanda Cássio ,&nbsp;Madalena Lira","doi":"10.1016/j.emcon.2025.100505","DOIUrl":"10.1016/j.emcon.2025.100505","url":null,"abstract":"<div><div>Contact Lens (CLs) are often disposed of via toilet or sinks, ending up in the wastewater treatment plants (WWTPs). Millions of CLs enter WWTPs worldwide each year in macro and micro sizes. Despite WWTPs' ability to remove solids, CLs can persist and potentially contaminate watercourses and soils.</div><div>This study evaluates whether different CLs degrade in WWTP aeration tanks. Six daily CLs (Nelfilcon A, Delefilcon A, Nesofilcon A, Stenfilcon A, Narafilcon A, Somofilcon A) and four monthly CLs (Lotrafilcon B, Comfilcon A, Senofilcon A, and Samfilcon A) were immersed in aeration tanks for twelve weeks. Their physical and chemical properties, including water content (WC), refractive index (RI), chemical properties (Fourier Transform Infrared Spectroscopy), and mechanical properties were assessed.</div><div>Results show that all CLs maintained their physical appearance after 12 weeks. Neither Nelfilcon A nor Narafilcon A exhibited significant changes in WC and RI, (p &gt; 0.05, Tukey test), while other daily lenses showed variations in at least one parameter.</div><div>Among monthly CLs, only Senofilcon A showed significant differences in both WC (<em>p</em> &lt; 0.001, Tukey test) and RI (<em>p</em> &lt; 0.0001, Tukey test). No differences in Young's modulus were observed for any lenses (p &gt; 0.05 Tukey test). However, Somofilcon A displayed significant changes in stress at break (<em>p</em> &lt; 0.0001, Tukey test), and Elongation at Break (<em>p</em> &lt; 0.05, Tukey test). No changes were found in the chemical structure of any CLs suggesting that twelve weeks in WWTP aeration tanks is insufficient for CLs degradation. These findings highlight CLs as a potential emerging pollutant, emphasizing their persistence in sludge or migration into watercourses and soils.</div></div>","PeriodicalId":11539,"journal":{"name":"Emerging Contaminants","volume":"11 3","pages":"Article 100505"},"PeriodicalIF":5.3,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143806783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fresh tire wear particles from moving vehicles: Dispersion dynamics, exposure, and prevention strategy","authors":"Yiwei Xu ,&nbsp;Licheng Wang ,&nbsp;Ruilin Wang ,&nbsp;Weiqi Jiang ,&nbsp;Longfei Du ,&nbsp;Haibo Huang ,&nbsp;Liwu Zhang ,&nbsp;Yan Ding","doi":"10.1016/j.emcon.2025.100503","DOIUrl":"10.1016/j.emcon.2025.100503","url":null,"abstract":"<div><div>Tire Wear Particles (TWPs) have emerged as a significant source of non-exhaust emissions, posing potential exposure risks due to increased vehicle ownership and the advent of new energy vehicles. However, the dispersion and flow dynamics of fresh TWPs remain largely unexplored. Here, we used a finite element aerodynamic simulation model to investigate the distribution of fresh TWPs from a moving vehicle and to assess human respiratory exposure near the vehicle. In addition, actual on-road particle level measurements were performed to qualitatively validate the results obtained from our model while developing a laboratory-scale emission reduction solution. Conservative data show that fresh TWPs (of 0.1–10 μm diameter) disperse up to 3.2 m wide and 2.2 m high, with minimal influence of particle size. At 1–2 m from the side of the vehicle driven at 60 km/h, the maximum concentration was found at a height of 0.8 m, reaching 5.0 μg/m3, demonstrating a significant exposure of children and adolescents. The emission reduction solution designed to mitigate the exposure risk (i.e., a collection channel mounted near the wheel cover) was shown to effectively reduce fresh TWP emissions, achieving a capture rate of &gt;40 % at high speeds. Overall, the results obtained underscore the potential health issues associated with TWPs in urban areas, but also the ability to reduce exposure, provided that appropriate mitigation strategies are adopted.</div></div>","PeriodicalId":11539,"journal":{"name":"Emerging Contaminants","volume":"11 3","pages":"Article 100503"},"PeriodicalIF":5.3,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143784041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urinary exposure level of emerging chemicals in Chinese pregnant women and their associations with oxidative stress","authors":"Henglin Zhang ,&nbsp;Yuxian Liu ,&nbsp;Yanan Zhao ,&nbsp;Jiye Zhang ,&nbsp;Luhan Yang ,&nbsp;Guanglan Zhang ,&nbsp;Yanpeng Cai ,&nbsp;Lan Yang ,&nbsp;Jianya Xi ,&nbsp;Ziliang Wang ,&nbsp;Hong Liang ,&nbsp;Maohua Miao ,&nbsp;Tao Zhang ,&nbsp;Jingchuan Xue","doi":"10.1016/j.emcon.2025.100502","DOIUrl":"10.1016/j.emcon.2025.100502","url":null,"abstract":"<div><div>Emerging chemicals (ECs), including parabens, bisphenols, bisphenol diglycidyl ethers, N,N′-substituted p-phenylenediamines, and benzotriazoles/benzothiazoles (BTH/BTRs), are widely used in industrial and consumer products. This study aimed to determine the urinary concentrations of 33 ECs and three oxidative stress biomarkers in pregnant women from a large birth cohort in Jiashan, China. Among the detected compounds, methyl paraben (MeP), bisphenol A (BPA), bisphenol A bis(2,3-dihydroxypropyl) glycidyl ether (BADGE·2H₂O), N-isopropyl-N′-phenyl-1,4-phenylenediamine quinone (IPPDQ), and 1H-benzotriazole (1-H-BTR) were the most prevalent, with median concentrations ranging from 0.51 to 9.02 ng/mL. Notably, BTH/BTRs exhibited the highest exposure levels, approximately 4–16 times greater than those of other ECs. Most ECs showed elevated concentrations in pregnant women who were exposed to secondhand smoke prior to pregnancy. After model analysis, we found that mixtures of ECs were positively associated with both 8-hydroxy-2′-deoxyguanosine (8-OHdG) and 15(R)-prostaglandin F_2α (15-PGF_2α), while a negative trend was observed between ECs and 8-iso-prostaglandin F_2α (8-PGF_2α). Specifically, urinary benzyl paraben (BzP), BPA, bisphenol S (BPS), N-(1,3-dimethylbutyl)-N′-phenyl-1,4-phenylenediamine quinone (6PPDQ), IPPDQ, 2(3H)-benzothiazole (2-OH-BTH), and 2-methylthio-benzothiazole (2-Me-S-BTH) or 1-H-BTR were significantly (<em>p</em> &lt; 0.05) associated with 8-OHdG. MeP, 6PPDQ, and 2-Me-S-BTH were linked to 15-PGF_2α, while only bisphenol A (2,3-dihydroxypropyl) glycidyl ether (BADGE·H₂O) showed a significant positive association with 8-PGF_2α. This study provides a comprehensive evaluation of the exposure characteristics of ECs and their associations with oxidative stress biomarkers in pregnant women, offering new insights into the health risks associated with ECs exposure during critical periods of pregnancy.</div></div>","PeriodicalId":11539,"journal":{"name":"Emerging Contaminants","volume":"11 2","pages":"Article 100502"},"PeriodicalIF":5.3,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143747940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}