Current Biotechnology最新文献

{"title":"Unleashing the Potential of Gut Microbiota: Cholesterol Reduction\u0000Through Microbial Bile Acid Metabolism","authors":"Md. Fakruddin, Nazia Nazrul Nafsi, Md. Ashiqur Rahman, Jinath Sultana Jime, Nayeema Bulbul, Md. Asaduzzaman Shishir, Md. Shamsul Arefin, Ashrafus Safa","doi":"10.2174/0122115501282536240301055402","DOIUrl":"https://doi.org/10.2174/0122115501282536240301055402","url":null,"abstract":"\u0000\u0000Cholesterol metabolism is a crucial mechanism for preserving cellular functionality,\u0000and overall human health. Cardiovascular diseases and other conditions can arise due to dysregulation\u0000of cholesterol levels. Bile acids’ enterohepatic circulation greatly influences cholesterol homeostasis.\u0000Recent research has emphasized the essential role of the gut microbiota in bile acid\u0000metabolism and its association with cholesterol regulation. Living microbial supplements known\u0000as probiotics have been studied as a potential means of reducing cholesterol by modifying the gut\u0000microbiome. This review explores existing theories of how probiotic production and modification\u0000of bile acids affect cholesterol metabolism. Discussion ensues regarding the processes by which\u0000probiotics lower cholesterol, including bile acid deconjugation, conversion of cholesterol to coprostanol\u0000and cholestenone, co-precipitation of cholesterol with deconjugated bile, and disruption\u0000of cholesterol micelles by Bile Salt Hydrolase (BSH). According to research, there are significant\u0000therapeutic ramifications in understanding the complex interactions between the gut microbiome\u0000and host cholesterol metabolism. More study is required to comprehend the causal mechanisms\u0000further and produce new methods for lowering microbiota-mediated cholesterol to enhance human\u0000health.\u0000","PeriodicalId":10850,"journal":{"name":"Current Biotechnology","volume":"24 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140258107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Depths of Marine Biotechnology: Discoveries, Diversity, and Future Horizons","authors":"Manoj Kumar Mishra, Ajay Kumar Shukla, S. K. Dev, Razi Ahmad","doi":"10.2174/0122115501291361240213105224","DOIUrl":"https://doi.org/10.2174/0122115501291361240213105224","url":null,"abstract":"\u0000\u0000Among the various technological advancements in different fields that help fulfill our\u0000needs further, marine biotechnology is one that has brought a significant change in the overall\u0000bleak outlook of the limited resources that the oceans have to offer. Marine biotechnology has not\u0000just revolutionized the method of farming and increased productivity, but it has also ensured a consistent\u0000supply to various cuisines throughout the world. In recent years, marine biotechnology has\u0000outgrown its traditional image in the seafood-related industry to one that caters to a plethora of industries\u0000such as enzyme technology, pharmaceuticals, tanning industry, cancer therapeutics, cosmetic\u0000industry, biodegradable polymers, and bioremediation. These are a few among a broad spectrum\u0000of industries where it finds applications and many more are yet to be explored. Remarkably,\u0000marine biotechnology has not only helped restore the normal local flora and fauna of the oceans\u0000but has also contributed extensively to conservation efforts. In this review, an attempt has been\u0000made to follow the trails of the wide applicability of marine biotechnology as well as its impact on\u0000various sectors in recent years.\u0000","PeriodicalId":10850,"journal":{"name":"Current Biotechnology","volume":"9 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140444430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Affecting the Micropropagation of Sapindus trifoliatus from Nodal Explants of Mature Tree","authors":"Pooja Asthana, Manoj K. Rai, U. Jaiswal","doi":"10.2174/0122115501289941240109061526","DOIUrl":"https://doi.org/10.2174/0122115501289941240109061526","url":null,"abstract":"\u0000\u0000Explant recalcitrance is one of the major challenges during the tissue culture of a tree species, especially when explants are derived from mature plants. It is mainly as-sociated with the genotypes/species, source and physiological status of explants, seasonal varia-tions, and competency/incompetency of explants towards PGRs for in vitro manipulations. There-fore, to optimize the appropriate conditions and minimize explant recalcitrance, it is necessary to elucidate the different factors influencing the tissue culture of a tree species.\u0000\u0000\u0000\u0000Several factors influencing in vitro shoot induction from nodal explants derived from mature plants of Sapindus trifoliatus were investigated.\u0000\u0000\u0000\u0000Nodal segment obtained from mature plants was used as an explant for shoot regenera-tion. The factors assessed in this study included the types and concentrations of plant growth reg-ulators, nutrient composition of MS (Murashige and Skoog) medium, sucrose concentrations, the position of nodes on their respective branches, seasonal variations, and successive transfers of mother explant.\u0000\u0000\u0000\u0000The performance of nodal explants was better on modified MS medium, i.e., M4 medi-um (half-strength of MS major salts and full-strengths of MS minor salts, Fe-EDTA and MS or-ganic nutrients each) than the full-strength MS medium. The addition of BAP in the medium re-sulted in a higher shoot induction rate than other cytokinins i.e., Kin, Zeatin, TDZ. M4 medium supplemented with 3.0 mg l-1 BAP and 2% sucrose was optimum for shoot proliferation. Howev-er, elongation of shoots was observed only when induced shoots, along with the mother explant, were subcultured on a medium containing 1.0 mg l-1 BAP. The shoot multiplication was positive-ly affected by the repeated transfer of the mother explant for different passages on the multiplica-tion medium. Mother explant transferred to multiplication medium (0.8% agar-solidified M4 me-dium + 2% sucrose + 1.0 mg l-1 BAP) proliferated maximum shoots after fourth passages. Regen-erated shoots were rooted in vitro and further successfully acclimatized in field conditions.\u0000\u0000\u0000\u0000The in vitro regeneration system developed from an explant obtained from mature trees can be successfully exploited for mass multiplication of Sapindus trifoliatus, a medicinally and commercially important tree.\u0000","PeriodicalId":10850,"journal":{"name":"Current Biotechnology","volume":" November","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139617911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation on Cross-correction of Cystinosis through Genetically\u0000Engineered Cells Secreting Cystinosin","authors":"V. Graceffa","doi":"10.2174/0122115501271925231130074832","DOIUrl":"https://doi.org/10.2174/0122115501271925231130074832","url":null,"abstract":"\u0000\u0000Cystinosis is a rare inherited lysosomal storage disease (LSD), caused by\u0000a mutation in the Cystinosin Lysosomal Cystine Transporter (CTNS). Novel therapies and strategies are needed to improve patients' clinical conditions and quality of life.\u0000\u0000\u0000\u0000This study assessed whether CTNS can be secreted, and investigated a\u0000method to enhance its secretion, by adding a secretion signal to the N-terminus. Human Embryonic Kidney (HEK) 293 cells were transfected with the resulting construct. The amount of protein\u0000secreted was then measured. Uptake by monolayer cultures of cystinotic cells and enzyme activity were also assessed.\u0000\u0000\u0000\u0000The recombinant protein could effectively be secreted, and the secretion signal slightly\u0000further increased its secretion. The secreted recombinant protein was taken up by cystinotic cells,\u0000and, after internalization, still retained its biological activity.\u0000\u0000\u0000\u0000Optimization of the proposed method to increase the secretion of CTNS would provide new insights into the production of recombinant proteins for medical and industrial use. Further identification and screening of alternative signalling peptides and cell types can maximise the\u0000secretion and production of recombinant CNTS, to be used as a therapeutic agent in human\u0000healthcare.\u0000","PeriodicalId":10850,"journal":{"name":"Current Biotechnology","volume":"22 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138602511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Docking Complexes of Active Phytochemicals with VK-deficient Genes","authors":"Shalini Rajagopal, Archa Nair, Rutuja Digraskar, Alekya Allu, Jalaja Naravula, Saji Menon, Sivaramaiah Nallapeta, Anil Kumar S, Sugunakar Vuree, G Bhanuprakash Reddy, Polavarapu Kavi, Bipin G. Nair, Girinath G. Pillai, Prashanth N Suravajhala, Renuka Suravajhala","doi":"10.2174/0122115501250686231017061958","DOIUrl":"https://doi.org/10.2174/0122115501250686231017061958","url":null,"abstract":"Background:: Vitamin K (VK) deficiency occurs when the body does not have enough vitamin K to produce proteins that are essential for blood clotting and bone health. Vitamin K is a cofactor that plays a major role in various comorbidities. Over the years, efforts have been made to identify the interaction between natural compounds, such as K vitamers, that could play a sig-nificant role in regulation of the blood coagulation. We intended to obtain insights into the poten-tial therapeutic implications of phytochemicals for treating VK deficiency-related diseases by in-vestigating the interactions between phytochemicals and VK-deficient genes. Methods:: On active phytochemical docking complexes with VK-deficient genes, there is no spe-cific information available as of yet. In this computationally aided docking study, we were inter-ested in finding the pathogenic blood coagulation-related genes that are linked to VK deficiency. Based on literature reviews and databases, bioactive phytochemicals and other ligands were con-sidered. To provide precise predictions of ligand-protein interactions, docking parameters and scoring algorithms were thoroughly optimized. We have performed molecular docking studies and observed the way the complexes interact. Results:: Specific binding interactions between active phytochemicals and VK pathogenic muta-tions have been identified by the docking study. Hydrogen bonds, van der Waals interactions, and hydrophobic contacts, which are indications of high binding affinities, have been observed in the ligand-protein complexes. Few phytochemicals have demonstrated the ability to interact with the targets of VK-deficient genes, indicating their capacity to modify pathways relevant to VK defi-ciency. The results of the docking study have explained the three pathogenic genes, viz. VWF, F8, and CFTR, wherein VWF and F8 play important roles in blood coagulation and people with cyst-ic fibrosis, to have a deficiency in vitamin K. Thirty-five compounds from different plant and natural sources were screened through molecular docking, out of which two compounds have been considered as controls, including curcumin and warfarin (R-warfarin and S-warfarin), which are the most common anticoagulants readily available in the market. They act by inhibiting vita-min K epoxide reductase (VKOR), which is needed for the gamma-carboxylation of vitamin K-dependent factors. Conclusion:: A focus on other compounds, like theaflavin, ellagic acid, myricetin, and catechin was also made in this study as they show more binding affinity with the three pathogenic proteins. Based on the results, the complexes have been found to possess great potential and thus may be considered for further interaction studies. The potential for active phytochemicals to generate docking complexes with VK-deficient genes is highlighted in this computational analysis. Health disorders related to VK insufficiency may be significantly impacted by these interactions. To val-id","PeriodicalId":10850,"journal":{"name":"Current Biotechnology","volume":"65 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135218845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro Regeneration of Multiple Shoots in Abelmoschus esculentus (L.) Moench (Okra) via Apical Shoot Meristem Culture","authors":"Melvin A. Daniel, S. Maria Packiam, Duraipandiyan Veeramuthu","doi":"10.2174/0122115501261522231013100629","DOIUrl":"https://doi.org/10.2174/0122115501261522231013100629","url":null,"abstract":"Introduction: To develop the efficient protocol for multiple shoot regeneration of A.esculentus by apical root culture method. Abelmoschus esculentus L., commonly known as okra, is a member of the Malvaceae family, which is widely consumed due to its high nutrient content and potential therapeutic properties. Okra contains various bioactive compounds that exhibit antibacterial properties and may be useful in treating type-2 diabetes, digestive diseases, and liver detoxification. To select the plant for the present and prepare the efficient protocol for the development of multiple shoot regeneration culture method. Methods: In this study, we developed an efficient protocol for multiple shoot regeneration of A. esculentus using the apical shoot culture method. Mature shoot apex explants of the germinated A. esculentus genotype CoBhH1 were cultured on Murashige and Skoog (MS) medium supplemented with different concentrations of cytokinins (BAP and TDZ) and auxins (IAA and NAA) to determine the optimal conditions for shoot induction. Results: The highest number of multiple shoots (27.04 shoots) was obtained with 0.8 mg/L TDZ. Excised shoots were cultured on MS medium supplemented with GA3, which induced elongation of the shoots to a maximum of 8-10 cm. Regenerated plantlets were successfully transferred to soil, with a 100% survival rate and no differences in morphology or growth characteristics compared to control plants. Rooting was achieved with 1 mg/L IBA. Conclusion: This study provides an efficient protocol for multiple shoot regeneration of A. esculentus through apical shoot culture, which has potential applications in plant breeding and genetic engineering.","PeriodicalId":10850,"journal":{"name":"Current Biotechnology","volume":"17 3-4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135167626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In silico Mining of Protein-coding and Non-coding RNA (ncRNA) Specific Genes in Exotic versus Indigenous Gaddi Dogs","authors":"Shilpa Tewari, Chandra Shekhar Mukhopadhyay","doi":"10.2174/0122115501261640231017061158","DOIUrl":"https://doi.org/10.2174/0122115501261640231017061158","url":null,"abstract":"Background: Comparative functional genomics will aid in the molecular identification of diverse dog breeds. Methods: The current proposal aimed at conducting a differential study between the genomes of exotic canines (Labrador, Basenji, Tasha-Boxer breed, Mischka breed German Shepherd, Zoey breed Great Dane) and indigenous (Gaddi) breeds through whole genome annotation. Result: The prediction analysis by GeneMark tool yielded an average of 46484 transcripts, in Gaddi dogs and exotic breeds ranging from 29669 to 30956. A total of 57 miRNAs were discovered in exotic breeds and 22 miRNAs in Gaddi dogs, 18 are common in both, while 4 were unique to Gaddi dogs. lncRNA was predicted using the PLEK, CPAT, and LGC tools, resulting in 3201, 396, and 4188 noncoding sequences in exotic breeds, respectively. Approximately, 31 thousand lncRNA transcripts were identified in the Gaddi dog genome. Microsatellites were found to be distributed through approximately 0.3% of both genomes. The average island length of CpG ranged between 24246.48 to 28080.66 in exotic breeds at chromosome level assembly and 697.15 in indigenous Gaddi dogs at contig level assembly. The predicted protein-coding genes were subjected to pathway analysis by DAVID and PANTHER. Five genes that are expressed in the blood (INSL3, CLDN3, MYH1, CLN5, and GALC) were selected for validation through qPCR. The results indicated that the genes were expressed in both groups. Conclusion: The study is the maiden report on the comparative genome analysis between indigenous Gaddi dogs and exotic dog breeds. The findings set the stage for further research into the known and novel genes, which might be employed as biomarkers for disease diagnosis and to investigate their regulatory role. other: Acknowledgment: The authors gratefully acknowledge the funding provided by the Department of Biotechnology, Government of India, through the collaborative research project “Parentage Determination and Cytogenetic Profiling in Dogs (DBT-19I)” and Dr. S.K Mahajan, who assisted with sample collection, deserves special recognition.","PeriodicalId":10850,"journal":{"name":"Current Biotechnology","volume":"18 6","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135315918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospection Of Therapeutic Agents Targeting Aurora Kinase, A Protein In The Treatment Of Acute Lymphoblastic Leukemia","authors":"Ana Beatriz da Lima, F. P. Mesquita, Pedro Filho Noronha Souza, R. Montenegro, C. R. de Andrade","doi":"10.2174/2211550112666230731104518","DOIUrl":"https://doi.org/10.2174/2211550112666230731104518","url":null,"abstract":"\u0000\u0000Acute lymphoblastic leukemia (ALL) is characterized by an imbalance in the production and development of hematopoietic lymphoid cells, a malignant disease capable of affecting the proliferation-selection of hematopoietic cells. The Aurora kinase A protein participates in several steps of the mitosis process. Its deregulation can trigger the process of carcinogenesis, which has become a therapeutic target of interest for computational prediction and the development of inhibitory drugs. Studies report its overexpression in malignant cells of patients with ALL.\u0000\u0000\u0000\u0000The present study aims to prospect new molecules to identify a potential inhibitor of Aurora kinase A for the pharmaceutical market.\u0000\u0000\u0000\u0000Virtual screening and molecular docking study was performed using the MCULE and DockThor web servers. The pharmacodynamic and pharmacokinetic profile of the molecules were evaluated using the Swiss ADME and ProTox-II programs were used.\u0000\u0000\u0000\u0000Ten molecules were identified by virtual screening, in which only two, MCULE-349 and MCULE-796, showed the best score, binding, at the site of action of the protein, interacting positively with amino acids, lipid-soluble molecules with low toxicity and with violation of only 1 Lipinski rule.\u0000\u0000\u0000\u0000Both molecules interact with the site of action, acting as inhibitors or blockers of the catalytic site, becoming potential Aurora kinase A inhibitors and anticancer molecules.\u0000","PeriodicalId":10850,"journal":{"name":"Current Biotechnology","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78891766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biocatalytic Attributes of Laccase and its Applications in Bioremediation","authors":"Reena Gupta, D. Sharma, Manisha Sharma, Rutika Sehgal, Sunita Borkar","doi":"10.2174/2211550112666230721102406","DOIUrl":"https://doi.org/10.2174/2211550112666230721102406","url":null,"abstract":"\u0000\u0000Laccases are proteins with multiple copper atoms that utilize molecular oxygen to catalyze the oxidation of organic compounds by a radical-catalyzed mechanism. They are the main focus of researchers due to their varied applications, for example, waste detoxification, textile transformation, and biosensor applications. Laccases help in the degradation of xenobiotics, such as polycyclic aromatic hydrocarbons, pesticides, and chlorinated phenolics. They are used to bleach textiles and decolorize dyes. They also play a bioremediatory role in the pulp and paper industry for the detoxification of effluent.\u0000Moreover, laccases help in the removal of detrimental micropollutants, such as nonylphenol and bisphenol A. They also degrade wastewater contaminants, such as 2-hydroxybiphenyl, naproxen, and diethyl phthalate. The remarkable biocatalytic attributes of laccases, coupled with their wide range of applications, make them a promising solution for the treatment of pollutants and contaminants.\u0000","PeriodicalId":10850,"journal":{"name":"Current Biotechnology","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87631788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Mini Review on the Application of Chitosan Composites for the Adsorption of Fluoride from Aqueous Solution","authors":"Clint Sutherland, Beverly Chittoo, Abd-Allah Islam","doi":"10.2174/2211550112666230719121415","DOIUrl":"https://doi.org/10.2174/2211550112666230719121415","url":null,"abstract":"\u0000\u0000Exploration into the development of cost-effective and eco-friendly adsorbents for the removal of fluoride continues to be unabated. The modification of chitosan through the\u0000development of composites and derivatives has shown great promise over the past decade.\u0000These modifications aim to overcome the limitation of chitosan, such as separability and adsorption\u0000capacity.\u0000\u0000\u0000\u0000The objective of this study is to review various modifications to chitosan for defluoridation, the resulting adsorption capacities, operational parameters that appreciably influence the fullscale application of adsorption systems and, where reported, the mechanisms that influenced the adsorption process.\u0000\u0000\u0000\u0000Among the adsorbents reviewed, most of the processes were best modelled\u0000by the Langmuir isotherm and the pseudo-second order model. Chitosan composites were able to\u0000achieve significantly higher F\u0000-\u0000adsorption capacities and compared well to other adsorbents in the\u0000literature. Gamma degraded chitosan-Fe(III) beads, 10%-Lanthanum-incorporated chitosan beads\u0000and neodymium-modified chitosan were found to easily achieve the WHO drinking water limit of\u00001.5 mg/L. In all instances, the reactions were spontaneous and endothermic. Fluoride adsorption\u0000was shown to increase from the acidic region to near neutral pH followed by a decrease into the alkaline range.\u0000\u0000\u0000\u0000The presence of competing ions is a major operational parameter for full-scale adsorption applications. The presence of carbonate and bicarbonate ions has been a consistent hindrance in\u0000reported studies. Thus, future investigations are warranted in this area.\u0000","PeriodicalId":10850,"journal":{"name":"Current Biotechnology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85320026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}