Environmental Science & Technology Letters Environ.最新文献

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IF 8.9 2区 环境科学与生态学
David Lutes, Ju Zhang, Lakshya Sethi, Andrew Boyd, Richard Arnseth, Ian Ross and Jinxia Liu*, 
{"title":"","authors":"David Lutes, Ju Zhang, Lakshya Sethi, Andrew Boyd, Richard Arnseth, Ian Ross and Jinxia Liu*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":37,"journal":{"name":"Environmental Science & Technology Letters Environ.","volume":"12 6","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":8.9,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.estlett.5c00251","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144418667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 8.9 2区 环境科学与生态学
{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":37,"journal":{"name":"Environmental Science & Technology Letters Environ.","volume":"12 6","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":8.9,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/ezv012i006_1944835","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144418671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 8.9 2区 环境科学与生态学
Jibao Liu, Bei Zhang, Qing-Long Fu*, Toshihiro Isobe, Rongjun Gao, Yuansong Wei, Eunsang Kwon, Zhineng Hao, Wei An, Rong Qi and Manabu Fujii*, 
{"title":"","authors":"Jibao Liu, Bei Zhang, Qing-Long Fu*, Toshihiro Isobe, Rongjun Gao, Yuansong Wei, Eunsang Kwon, Zhineng Hao, Wei An, Rong Qi and Manabu Fujii*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":37,"journal":{"name":"Environmental Science & Technology Letters Environ.","volume":"12 6","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":8.9,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.estlett.5c00284","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144354510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Strong Convergence of Floating Microplastics at a Small-Scale Estuarine Surface Front 小型河口表面锋面上漂浮微塑料的强收敛
IF 8.8 2区 环境科学与生态学
Environmental Science & Technology Letters Environ. Pub Date : 2025-06-09 DOI: 10.1021/acs.estlett.5c00322
Mui-Choo Jong*, Xuneng Tong, Mengli Chen*, Serene Hui Xin Tay, Dieu Huong Trinh, Yuanyu Cao, Shiye Zhao, Shasha Lu, Edward Park, Huahong Shi and Karina Yew-Hoong Gin, 
{"title":"Strong Convergence of Floating Microplastics at a Small-Scale Estuarine Surface Front","authors":"Mui-Choo Jong*,&nbsp;Xuneng Tong,&nbsp;Mengli Chen*,&nbsp;Serene Hui Xin Tay,&nbsp;Dieu Huong Trinh,&nbsp;Yuanyu Cao,&nbsp;Shiye Zhao,&nbsp;Shasha Lu,&nbsp;Edward Park,&nbsp;Huahong Shi and Karina Yew-Hoong Gin,&nbsp;","doi":"10.1021/acs.estlett.5c00322","DOIUrl":"https://doi.org/10.1021/acs.estlett.5c00322","url":null,"abstract":"<p >Estuarine surface fronts, where freshwater outflow and saline tidal inflow converge, may play a critical yet understudied role in microplastic (MP) accumulation. This study presents compelling evidence of strong convergence of MP at a small-scale surface front near the Eastern Johor Strait (EJS), a typical urbanized coast in Southeast Asia, revealing an estuary tidal intrusion front as a recurrent hotspot that concentrates MP at levels comparable to known estuarine frontal systems. Significantly elevated levels of floating microplastics (150.5 ± 19.8 MP pieces/L) were detected at the surface front compared to other surface water samples along the coast (<i>p</i> &lt; 0.001; 9.2 ± 4.8 MP pieces/L). Hydrodynamic simulations demonstrate that the dynamic interplay between freshwater and seawater are the key mechanisms governing this process. The resulting convergence zones effectively trap buoyant plastics, forming quasi-persistent accumulation zones. Specifically, during ebb tide, parallel outflows from the Johor River and inner EJS amplify frontal convergence, actively trapping floating plastics at the salinity boundary. These findings highlight estuarine surface fronts as influential and previously underquantified systemic pathways influencing MP circulation and retention at marginal seas. Recognizing these traceable accumulation hotspots at ocean boundaries is an urgent priority, offering opportunities for targeted mitigation, particularly in high-leakage regions.</p>","PeriodicalId":37,"journal":{"name":"Environmental Science & Technology Letters Environ.","volume":"12 8","pages":"1009–1018"},"PeriodicalIF":8.8,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144813831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
East African City Centers Show Lower PM2.5 Levels than Their Suburbs 东非城市中心的PM2.5浓度低于郊区
IF 8.8 2区 环境科学与生态学
Environmental Science & Technology Letters Environ. Pub Date : 2025-06-09 DOI: 10.1021/acs.estlett.5c00451
Samuel De Xun Chua*, Otienoh Oguge, Celestine Atieno Oliewo, Richard Sserunjogi, Deo Okure, Priscilla Adong, Asinta Manyele, Tareq Hussein, Yuheng Yang, Xixi Lu, Katrianne Lehtipalo, Martha Arbayani Zaidan and Tuukka Petäjä, 
{"title":"East African City Centers Show Lower PM2.5 Levels than Their Suburbs","authors":"Samuel De Xun Chua*,&nbsp;Otienoh Oguge,&nbsp;Celestine Atieno Oliewo,&nbsp;Richard Sserunjogi,&nbsp;Deo Okure,&nbsp;Priscilla Adong,&nbsp;Asinta Manyele,&nbsp;Tareq Hussein,&nbsp;Yuheng Yang,&nbsp;Xixi Lu,&nbsp;Katrianne Lehtipalo,&nbsp;Martha Arbayani Zaidan and Tuukka Petäjä,&nbsp;","doi":"10.1021/acs.estlett.5c00451","DOIUrl":"https://doi.org/10.1021/acs.estlett.5c00451","url":null,"abstract":"<p >Urban air pollution remains a pressing challenge in rapidly developing economies, particularly in data-scarce regions. This study examined air quality in three major East African cities─Kampala, Nairobi, and Dar es Salaam─by integrating low-cost air sensors with satellite data to produce 1 km × 1 km resolution daily PM<sub>2.5</sub> (particulate matter smaller than 2.5 μm) maps from 2019 to 2023. Average PM<sub>2.5</sub> concentrations were 31.4 ± 6.6 μg/m<sup>3</sup> around Kampala, 21.7 ± 2.8 μg/m<sup>3</sup> around Nairobi, and 33.1 ± 7.4 μg/m<sup>3</sup> around Dar es Salaam, indicating moderate to unhealthy levels of air quality. Unexpectedly, urban centers exhibited lower PM<sub>2.5</sub> levels than surrounding suburban area. This discrepancy is likely due to combustion-related activities that occur in the suburbs. Such results suggest that air quality mitigation efforts must extend beyond urban centers to suburban areas, where seasonal vegetation loss and combustion processes may drive pollution spikes. Beyond presenting a scalable approach for monitoring air quality in data-scarce regions, this study highlights the importance of localized strategies for urban air quality management.</p>","PeriodicalId":37,"journal":{"name":"Environmental Science & Technology Letters Environ.","volume":"12 9","pages":"1169–1176"},"PeriodicalIF":8.8,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.estlett.5c00451","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145009595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preparing for the Next Generation of Material Environmental Health and Safety (EHS) Concerns: Guidelines for Future Data Curation Collaborations 为下一代材料环境健康和安全(EHS)问题做准备:未来数据管理合作指南
IF 8.8 2区 环境科学与生态学
Environmental Science & Technology Letters Environ. Pub Date : 2025-06-04 DOI: 10.1021/acs.estlett.5c00311
Jaleesia D. Amos, Anastasios G. Papadiamantis, Camille de Garidel-Thoron, Zhao Zhang, Yuan Tian, Gregory V. Lowry, Iseult Lynch, Jérôme Rose, Armand Masion, Lee A. Walker, Mélanie Auffan, Claus Svendsen, Christine Ogilvie Hendren and Mark R. Wiesner*, 
{"title":"Preparing for the Next Generation of Material Environmental Health and Safety (EHS) Concerns: Guidelines for Future Data Curation Collaborations","authors":"Jaleesia D. Amos,&nbsp;Anastasios G. Papadiamantis,&nbsp;Camille de Garidel-Thoron,&nbsp;Zhao Zhang,&nbsp;Yuan Tian,&nbsp;Gregory V. Lowry,&nbsp;Iseult Lynch,&nbsp;Jérôme Rose,&nbsp;Armand Masion,&nbsp;Lee A. Walker,&nbsp;Mélanie Auffan,&nbsp;Claus Svendsen,&nbsp;Christine Ogilvie Hendren and Mark R. Wiesner*,&nbsp;","doi":"10.1021/acs.estlett.5c00311","DOIUrl":"https://doi.org/10.1021/acs.estlett.5c00311","url":null,"abstract":"<p >Emergence of a new class of nanoscaled contaminants, such as micro- and nanoplastics, as well as nanotechnology’s current transition into advanced materials have broadened the boundaries of the field. These field-expanding topics exemplify the core role of collaboration in creating “good” and trustable data for future analyses. It is imperative that the environmental health and safety community recalls previous efforts to integrate data surrounding engineered nanomaterials to serve as guidance for the next generation of materials. We therefore describe an international collaboration focused at the early stages in the informatics process, the data curation level. Our experiences are described in nine guidelines that can be adopted by future collaborations. These guidelines were written to be actionable and structured within scalable phases. Guidance is also provided on the necessary personnel roles that should be incorporated into funding plans for developing and using advanced materials. Current shifts in the field demand community consensus to define data that are qualified as “good” and “trustable”, which require collaboration at the early stages of the informatics and data generation processes.</p>","PeriodicalId":37,"journal":{"name":"Environmental Science & Technology Letters Environ.","volume":"12 7","pages":"776–784"},"PeriodicalIF":8.8,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144808918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Aspiration in Legionnaires’ Disease: A Quantitative Microbial Risk Assessment (QMRA)-Based Comparison with Inhalation Exposures 吸入在军团病中的作用:基于定量微生物风险评估(QMRA)与吸入暴露的比较
IF 8.8 2区 环境科学与生态学
Environmental Science & Technology Letters Environ. Pub Date : 2025-06-04 DOI: 10.1021/acs.estlett.5c00488
Hunter Quon*, Divya Ram, Émile Sylvestre and Kerry A. Hamilton, 
{"title":"The Role of Aspiration in Legionnaires’ Disease: A Quantitative Microbial Risk Assessment (QMRA)-Based Comparison with Inhalation Exposures","authors":"Hunter Quon*,&nbsp;Divya Ram,&nbsp;Émile Sylvestre and Kerry A. Hamilton,&nbsp;","doi":"10.1021/acs.estlett.5c00488","DOIUrl":"https://doi.org/10.1021/acs.estlett.5c00488","url":null,"abstract":"<p >Legionellosis is generally attributed to the inhalation of aerosolized <i>Legionella pneumophila</i> from engineered water systems and/or soils. However, aspiration of contaminated water─a known cause of aspiration pneumonia─is seldom modeled in <i>L. pneumophila</i> risk assessment. Here, we develop a quantitative microbial risk assessment model to estimate the risks associated with aspiration exposures. Monte Carlo simulations, incorporating the aspiration water volume, the aspiration frequency, and the alveolar deposition fraction, reveal that low <i>L. pneumophila</i> concentrations in water can yield an appreciable infection risk in populations prone to aspiration. Under equal <i>L. pneumophila</i> concentrations, we find that an aspiration event can pose a higher infection risk than aerosol inhalation from showers or faucets. Sensitivity analyses identify the aspiration volume as a driver of risk. Our findings highlight the need for risk management strategies that address not only aerosol generation but also the aspiration of contaminated water.</p>","PeriodicalId":37,"journal":{"name":"Environmental Science & Technology Letters Environ.","volume":"12 7","pages":"785–791"},"PeriodicalIF":8.8,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144808920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thermodynamic and Kinetic Insights into Single Electron Transfer Pathway of Reactive Halogen Species: Is the Reduction Potential a Reliable Indicator for Radical Reactivity? 反应卤素单电子转移途径的热力学和动力学研究:还原电位是自由基反应的可靠指标吗?
IF 8.9 2区 环境科学与生态学
Environmental Science & Technology Letters Environ. Pub Date : 2025-05-27 DOI: 10.1021/acs.estlett.5c0047210.1021/acs.estlett.5c00472
Wenlei Qin, Zhechao Hua, Kaiheng Guo and Jingyun Fang*, 
{"title":"Thermodynamic and Kinetic Insights into Single Electron Transfer Pathway of Reactive Halogen Species: Is the Reduction Potential a Reliable Indicator for Radical Reactivity?","authors":"Wenlei Qin,&nbsp;Zhechao Hua,&nbsp;Kaiheng Guo and Jingyun Fang*,&nbsp;","doi":"10.1021/acs.estlett.5c0047210.1021/acs.estlett.5c00472","DOIUrl":"https://doi.org/10.1021/acs.estlett.5c00472https://doi.org/10.1021/acs.estlett.5c00472","url":null,"abstract":"<p >Single electron transfer (SET) is the most important reaction mechanism of reactive halogen species (RHS) (e.g., Cl<sup>•</sup>, Cl<sub>2</sub><sup>•–</sup>, Br<sup>•</sup>, and Br<sub>2</sub><sup>•–</sup>) with aromatic contaminants. However, the key parameters governing the reactivity of RHS via the SET pathway remain unclear. This study comprehensively investigated the SET pathway of the RHS with 51 aromatic contaminants by quantum-chemical calculations. The calculated free energy changes of the SET pathway (Δ<i>G</i><sub>aq,SET</sub><sup>R</sup>) followed the order Cl<sup>•</sup> &lt; Cl<sub>2</sub><sup>•–</sup> &lt; Br<sup>•</sup> &lt; Br<sub>2</sub><sup>•–</sup>, which was consistent with the order of their reduction potentials. However, the free energy of activation of the SET pathway (Δ<i>G</i><sub>aq,SET</sub><sup>⧧</sup>) followed a different order of Cl<sup>•</sup> &lt; Br<sup>•</sup> &lt; Cl<sub>2</sub><sup>•–</sup> &lt; Br<sub>2</sub><sup>•–</sup>, which agreed with the order of their rate constants. This inconsistent trend between Δ<i>G</i><sub>aq,SET</sub><sup>R</sup> and Δ<i>G</i><sub>aq,SET</sub><sup>⧧</sup> for RHS reactions was attributed to the difference in reorganization energy, which is essentially related to the vertical electron affinity and radius of RHS. Therefore, the rate constants of SET reactions of RHS depend not only on their reduction potential but also on their vertical electron affinity and radius. These findings unravel the key factors determining the reactivity of RHS via the SET pathway and have profound implications for understanding other SET processes in water.</p>","PeriodicalId":37,"journal":{"name":"Environmental Science & Technology Letters Environ.","volume":"12 6","pages":"761–767 761–767"},"PeriodicalIF":8.9,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144238352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Marine Modulation of the Formation Pathways and Sources of Organosulfates over the Coastal South China Sea 南海沿海有机硫酸盐形成途径和来源的海洋调节
IF 8.9 2区 环境科学与生态学
Environmental Science & Technology Letters Environ. Pub Date : 2025-05-25 DOI: 10.1021/acs.estlett.5c0040610.1021/acs.estlett.5c00406
Yucheng Zhu, Hao Li, Junjie Wei, Hao Ding, Dongmei Cai, Xuan Zou, Guochen Wang, Qiongzhen Wang, Zhijian Ding, Ziwei Liu, Jia Chen, Long Yun, Congrui Deng and Kan Huang*, 
{"title":"Marine Modulation of the Formation Pathways and Sources of Organosulfates over the Coastal South China Sea","authors":"Yucheng Zhu,&nbsp;Hao Li,&nbsp;Junjie Wei,&nbsp;Hao Ding,&nbsp;Dongmei Cai,&nbsp;Xuan Zou,&nbsp;Guochen Wang,&nbsp;Qiongzhen Wang,&nbsp;Zhijian Ding,&nbsp;Ziwei Liu,&nbsp;Jia Chen,&nbsp;Long Yun,&nbsp;Congrui Deng and Kan Huang*,&nbsp;","doi":"10.1021/acs.estlett.5c0040610.1021/acs.estlett.5c00406","DOIUrl":"https://doi.org/10.1021/acs.estlett.5c00406https://doi.org/10.1021/acs.estlett.5c00406","url":null,"abstract":"<p >Organosulfates (OSs) constitute a considerable part of airborne sulfur-containing organic aerosols, influencing aerosol physicochemical properties, biogeochemical cycles, and climate. This study investigated the compositions, formation pathways, and sources of OSs at a coastal site of the South China Sea in summer. Thirty-three OS species were quantified by using an UHPLC-Orbitrap MS and were assessed under marine and terrestrial air mass origins. iOSs (isoprene-derived OSs) ranked the highest, followed by C2/C3 OSs (OSs with two or three carbon atoms). The formation of iOSs was influenced by aerosol pH and their major precursor (isoprene), with photochemical processes playing a significant role in terrestrial transport. Different from urban conditions, sea breezes favored the formation of 2-MAS (C<sub>4</sub>H<sub>7</sub>O<sub>7</sub>S<sup>–</sup>) over 2-MTS (C<sub>5</sub>H<sub>11</sub>O<sub>7</sub>S<sup>–</sup>) even under low NO<sub><i>x</i></sub> levels, mainly attributed to the high temperature and dominance of aqueous oxidation. Compared to terrestrial transport, the formation of C2/C3 OSs was more favored than that of iOSs under the influence of sea breezes. Marine biogenic emission was quantified as an important source of C2/C3 OSs. This study enhances our understanding of the influence of both terrestrial and marine factors on the formation pathways of atmospheric OSs and emphasizes the significant contribution of marine biogenic sources to OSs.</p>","PeriodicalId":37,"journal":{"name":"Environmental Science & Technology Letters Environ.","volume":"12 6","pages":"739–746 739–746"},"PeriodicalIF":8.9,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144238734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phenotypic Profiling of 6PPD, 6PPD-Quinone, and Structurally Diverse Antiozonants in RTgill-W1 Cells Using the Cell Painting Assay RTgill-W1细胞中6PPD、6PPD醌和结构多样的抗臭氧物质的表型分析
IF 8.9 2区 环境科学与生态学
Environmental Science & Technology Letters Environ. Pub Date : 2025-05-23 DOI: 10.1021/acs.estlett.5c0032710.1021/acs.estlett.5c00327
Felix R. Harris, Mark D. Jankowski, Daniel L. Villeneuve and Joshua A. Harrill*, 
{"title":"Phenotypic Profiling of 6PPD, 6PPD-Quinone, and Structurally Diverse Antiozonants in RTgill-W1 Cells Using the Cell Painting Assay","authors":"Felix R. Harris,&nbsp;Mark D. Jankowski,&nbsp;Daniel L. Villeneuve and Joshua A. Harrill*,&nbsp;","doi":"10.1021/acs.estlett.5c0032710.1021/acs.estlett.5c00327","DOIUrl":"https://doi.org/10.1021/acs.estlett.5c00327https://doi.org/10.1021/acs.estlett.5c00327","url":null,"abstract":"<p >6PPD-quinone, a degradation product of the rubber antiozonant 6PPD that is frequently added to tires, has previously been identified as a causative agent of urban runoff mortality syndrome in salmonids. Previous high-throughput phenotypic profiling (HTPP) studies using the Cell Painting assay in the RTgill-W1 rainbow trout cell line have demonstrated that 6PPD-quinone toxicity occurs at much lower concentrations than the 6PPD parent molecule, which is consistent with available <i>in vivo</i> toxicity data in rainbow trout. Current research efforts include identifying alternative antiozonant compounds to potentially replace 6PPD in tire manufacturing. To fill bioactivity data gaps for potential 6PPD alternatives, 18 compounds including other substituted <i>p</i>-phenylenediamines (PPD) and PPD-quinones were assayed using HTPP in RTgill-W1 cells. 7PPD-quinone and 77PD-quinone produced changes in cellular phenotype similar to those of 6PPD-quinone at comparable concentrations. IPPD-quinone produced changes in cellular phenotype at higher concentrations than 6PPD-quinone, with a phenotypic profile that was most similar to its parent molecule IPPD. These findings suggest that 7PPD-quinone and 77PD-quinone may exhibit similar effects in rainbow trout and potentially other 6PPD-quinone sensitive salmonids. In contrast, IPPD may be less toxic to salmonids than 6PPD, given the relative lack of bioactivity of IPPD-quinone compared to 6PPD-quinone.</p>","PeriodicalId":37,"journal":{"name":"Environmental Science & Technology Letters Environ.","volume":"12 6","pages":"695–701 695–701"},"PeriodicalIF":8.9,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144238928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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